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Supplementary data
RBFOX2 enforces the mesenchymal splicing signature in normal and cancer tissues
7. 26 switch-like targets from epithelium and mesenchyme (fetal colon) in RBFOX2, MBNL1, PTBP and ESRP knockdowns
Transcript map
: MARK2 Control (MDA-MB-231)
Exon
Length: 138
Transcript: NM_001039468
Length: 138
Transcript: NM_001039468
Exon
Length: 180
Transcript: NM_001039468
Length: 180
Transcript: NM_001039468
Exon
Length: 54
Transcript: NM_001039468
Length: 54
Transcript: NM_001039468
Exon
Length: 49
Transcript: NM_001039468
Length: 49
Transcript: NM_001039468
Exon
Length: 66
Transcript: NM_001039468
Length: 66
Transcript: NM_001039468
Exon
Length: 71
Transcript: NM_001039468
Length: 71
Transcript: NM_001039468
Exon
Length: 57
Transcript: NM_001039468
Length: 57
Transcript: NM_001039468
Exon
Length: 237
Transcript: NM_001039468
Length: 237
Transcript: NM_001039468
Exon
Length: 120
Transcript: NM_001039468
Length: 120
Transcript: NM_001039468
Exon
Length: 100
Transcript: NM_001039468
Length: 100
Transcript: NM_001039468
Exon
Length: 113
Transcript: NM_001039468
Length: 113
Transcript: NM_001039468
Exon
Length: 133
Transcript: NM_001039468
Length: 133
Transcript: NM_001039468
Exon
Length: 179
Transcript: NM_001039468
Length: 179
Transcript: NM_001039468
Exon
Length: 98
Transcript: NM_001039468
Length: 98
Transcript: NM_001039468
Exon
Length: 258
Transcript: NM_001039468
Length: 258
Transcript: NM_001039468
Exon
Length: 45
Transcript: NM_001039468
Length: 45
Transcript: NM_001039468
Exon
Length: 509
Transcript: NM_001039468
Length: 509
Transcript: NM_001039468
Exon
Length: 160
Transcript: NM_001039468
Length: 160
Transcript: NM_001039468
Intron
Length: 55598
Transcript: NM_001039468
Length: 55598
Transcript: NM_001039468
Intron
Length: 241
Transcript: NM_001039468
Length: 241
Transcript: NM_001039468
Intron
Length: 2598
Transcript: NM_001039468
Length: 2598
Transcript: NM_001039468
Intron
Length: 327
Transcript: NM_001039468
Length: 327
Transcript: NM_001039468
Intron
Length: 89
Transcript: NM_001039468
Length: 89
Transcript: NM_001039468
Intron
Length: 218
Transcript: NM_001039468
Length: 218
Transcript: NM_001039468
Intron
Length: 765
Transcript: NM_001039468
Length: 765
Transcript: NM_001039468
Intron
Length: 448
Transcript: NM_001039468
Length: 448
Transcript: NM_001039468
Intron
Length: 101
Transcript: NM_001039468
Length: 101
Transcript: NM_001039468
Intron
Length: 77
Transcript: NM_001039468
Length: 77
Transcript: NM_001039468
Intron
Length: 1128
Transcript: NM_001039468
Length: 1128
Transcript: NM_001039468
Intron
Length: 273
Transcript: NM_001039468
Length: 273
Transcript: NM_001039468
Intron
Length: 278
Transcript: NM_001039468
Length: 278
Transcript: NM_001039468
Intron
Length: 1627
Transcript: NM_001039468
Length: 1627
Transcript: NM_001039468
Intron
Length: 3216
Transcript: NM_001039468
Length: 3216
Transcript: NM_001039468
Intron
Length: 572
Transcript: NM_001039468
Length: 572
Transcript: NM_001039468
Intron
Length: 40
Transcript: NM_001039468
Length: 40
Transcript: NM_001039468
Reaction
Expected peak: 112
51.9M
refseq_MARK2.F4
refseq_MARK2.R4
Expected peak: 112
51.9M
refseq_MARK2.F4
refseq_MARK2.R4
Exon
Length: 180
Transcript: NM_001039469
Length: 180
Transcript: NM_001039469
Exon
Length: 54
Transcript: NM_001039469
Length: 54
Transcript: NM_001039469
Exon
Length: 49
Transcript: NM_001039469
Length: 49
Transcript: NM_001039469
Exon
Length: 66
Transcript: NM_001039469
Length: 66
Transcript: NM_001039469
Exon
Length: 71
Transcript: NM_001039469
Length: 71
Transcript: NM_001039469
Exon
Length: 57
Transcript: NM_001039469
Length: 57
Transcript: NM_001039469
Exon
Length: 237
Transcript: NM_001039469
Length: 237
Transcript: NM_001039469
Exon
Length: 120
Transcript: NM_001039469
Length: 120
Transcript: NM_001039469
Exon
Length: 100
Transcript: NM_001039469
Length: 100
Transcript: NM_001039469
Exon
Length: 113
Transcript: NM_001039469
Length: 113
Transcript: NM_001039469
Exon
Length: 133
Transcript: NM_001039469
Length: 133
Transcript: NM_001039469
Exon
Length: 182
Transcript: NM_001039469
Length: 182
Transcript: NM_001039469
Exon
Length: 98
Transcript: NM_001039469
Length: 98
Transcript: NM_001039469
Exon
Length: 162
Transcript: NM_001039469
Length: 162
Transcript: NM_001039469
Exon
Length: 258
Transcript: NM_001039469
Length: 258
Transcript: NM_001039469
Exon
Length: 27
Transcript: NM_001039469
Length: 27
Transcript: NM_001039469
Exon
Length: 45
Transcript: NM_001039469
Length: 45
Transcript: NM_001039469
Exon
Length: 702
Transcript: NM_001039469
Length: 702
Transcript: NM_001039469
Intron
Length: 241
Transcript: NM_001039469
Length: 241
Transcript: NM_001039469
Intron
Length: 2598
Transcript: NM_001039469
Length: 2598
Transcript: NM_001039469
Intron
Length: 327
Transcript: NM_001039469
Length: 327
Transcript: NM_001039469
Intron
Length: 89
Transcript: NM_001039469
Length: 89
Transcript: NM_001039469
Intron
Length: 218
Transcript: NM_001039469
Length: 218
Transcript: NM_001039469
Intron
Length: 765
Transcript: NM_001039469
Length: 765
Transcript: NM_001039469
Intron
Length: 448
Transcript: NM_001039469
Length: 448
Transcript: NM_001039469
Intron
Length: 101
Transcript: NM_001039469
Length: 101
Transcript: NM_001039469
Intron
Length: 77
Transcript: NM_001039469
Length: 77
Transcript: NM_001039469
Intron
Length: 1128
Transcript: NM_001039469
Length: 1128
Transcript: NM_001039469
Intron
Length: 270
Transcript: NM_001039469
Length: 270
Transcript: NM_001039469
Intron
Length: 278
Transcript: NM_001039469
Length: 278
Transcript: NM_001039469
Intron
Length: 827
Transcript: NM_001039469
Length: 827
Transcript: NM_001039469
Intron
Length: 638
Transcript: NM_001039469
Length: 638
Transcript: NM_001039469
Intron
Length: 1044
Transcript: NM_001039469
Length: 1044
Transcript: NM_001039469
Intron
Length: 2145
Transcript: NM_001039469
Length: 2145
Transcript: NM_001039469
Intron
Length: 572
Transcript: NM_001039469
Length: 572
Transcript: NM_001039469
Reaction
Expected peak: 274
15.1M
refseq_MARK2.F4
refseq_MARK2.R4
Expected peak: 274
15.1M
refseq_MARK2.F4
refseq_MARK2.R4
Exon
Length: 362
Transcript: NM_004954
Length: 362
Transcript: NM_004954
Exon
Length: 180
Transcript: NM_004954
Length: 180
Transcript: NM_004954
Exon
Length: 54
Transcript: NM_004954
Length: 54
Transcript: NM_004954
Exon
Length: 49
Transcript: NM_004954
Length: 49
Transcript: NM_004954
Exon
Length: 66
Transcript: NM_004954
Length: 66
Transcript: NM_004954
Exon
Length: 71
Transcript: NM_004954
Length: 71
Transcript: NM_004954
Exon
Length: 57
Transcript: NM_004954
Length: 57
Transcript: NM_004954
Exon
Length: 237
Transcript: NM_004954
Length: 237
Transcript: NM_004954
Exon
Length: 120
Transcript: NM_004954
Length: 120
Transcript: NM_004954
Exon
Length: 100
Transcript: NM_004954
Length: 100
Transcript: NM_004954
Exon
Length: 113
Transcript: NM_004954
Length: 113
Transcript: NM_004954
Exon
Length: 133
Transcript: NM_004954
Length: 133
Transcript: NM_004954
Exon
Length: 179
Transcript: NM_004954
Length: 179
Transcript: NM_004954
Exon
Length: 98
Transcript: NM_004954
Length: 98
Transcript: NM_004954
Exon
Length: 258
Transcript: NM_004954
Length: 258
Transcript: NM_004954
Exon
Length: 45
Transcript: NM_004954
Length: 45
Transcript: NM_004954
Exon
Length: 509
Transcript: NM_004954
Length: 509
Transcript: NM_004954
Exon
Length: 160
Transcript: NM_004954
Length: 160
Transcript: NM_004954
Intron
Length: 6194
Transcript: NM_004954
Length: 6194
Transcript: NM_004954
Intron
Length: 241
Transcript: NM_004954
Length: 241
Transcript: NM_004954
Intron
Length: 2598
Transcript: NM_004954
Length: 2598
Transcript: NM_004954
Intron
Length: 327
Transcript: NM_004954
Length: 327
Transcript: NM_004954
Intron
Length: 89
Transcript: NM_004954
Length: 89
Transcript: NM_004954
Intron
Length: 218
Transcript: NM_004954
Length: 218
Transcript: NM_004954
Intron
Length: 765
Transcript: NM_004954
Length: 765
Transcript: NM_004954
Intron
Length: 448
Transcript: NM_004954
Length: 448
Transcript: NM_004954
Intron
Length: 101
Transcript: NM_004954
Length: 101
Transcript: NM_004954
Intron
Length: 77
Transcript: NM_004954
Length: 77
Transcript: NM_004954
Intron
Length: 1128
Transcript: NM_004954
Length: 1128
Transcript: NM_004954
Intron
Length: 273
Transcript: NM_004954
Length: 273
Transcript: NM_004954
Intron
Length: 278
Transcript: NM_004954
Length: 278
Transcript: NM_004954
Intron
Length: 1627
Transcript: NM_004954
Length: 1627
Transcript: NM_004954
Intron
Length: 3216
Transcript: NM_004954
Length: 3216
Transcript: NM_004954
Intron
Length: 572
Transcript: NM_004954
Length: 572
Transcript: NM_004954
Intron
Length: 40
Transcript: NM_004954
Length: 40
Transcript: NM_004954
Reaction
Expected peak: 112
51.9M
refseq_MARK2.F4
refseq_MARK2.R4
Expected peak: 112
51.9M
refseq_MARK2.F4
refseq_MARK2.R4
Exon
Length: 362
Transcript: NM_017490
Length: 362
Transcript: NM_017490
Exon
Length: 180
Transcript: NM_017490
Length: 180
Transcript: NM_017490
Exon
Length: 54
Transcript: NM_017490
Length: 54
Transcript: NM_017490
Exon
Length: 49
Transcript: NM_017490
Length: 49
Transcript: NM_017490
Exon
Length: 66
Transcript: NM_017490
Length: 66
Transcript: NM_017490
Exon
Length: 71
Transcript: NM_017490
Length: 71
Transcript: NM_017490
Exon
Length: 57
Transcript: NM_017490
Length: 57
Transcript: NM_017490
Exon
Length: 237
Transcript: NM_017490
Length: 237
Transcript: NM_017490
Exon
Length: 120
Transcript: NM_017490
Length: 120
Transcript: NM_017490
Exon
Length: 100
Transcript: NM_017490
Length: 100
Transcript: NM_017490
Exon
Length: 113
Transcript: NM_017490
Length: 113
Transcript: NM_017490
Exon
Length: 133
Transcript: NM_017490
Length: 133
Transcript: NM_017490
Exon
Length: 179
Transcript: NM_017490
Length: 179
Transcript: NM_017490
Exon
Length: 98
Transcript: NM_017490
Length: 98
Transcript: NM_017490
Exon
Length: 162
Transcript: NM_017490
Length: 162
Transcript: NM_017490
Exon
Length: 258
Transcript: NM_017490
Length: 258
Transcript: NM_017490
Exon
Length: 45
Transcript: NM_017490
Length: 45
Transcript: NM_017490
Exon
Length: 509
Transcript: NM_017490
Length: 509
Transcript: NM_017490
Exon
Length: 160
Transcript: NM_017490
Length: 160
Transcript: NM_017490
Intron
Length: 6194
Transcript: NM_017490
Length: 6194
Transcript: NM_017490
Intron
Length: 241
Transcript: NM_017490
Length: 241
Transcript: NM_017490
Intron
Length: 2598
Transcript: NM_017490
Length: 2598
Transcript: NM_017490
Intron
Length: 327
Transcript: NM_017490
Length: 327
Transcript: NM_017490
Intron
Length: 89
Transcript: NM_017490
Length: 89
Transcript: NM_017490
Intron
Length: 218
Transcript: NM_017490
Length: 218
Transcript: NM_017490
Intron
Length: 765
Transcript: NM_017490
Length: 765
Transcript: NM_017490
Intron
Length: 448
Transcript: NM_017490
Length: 448
Transcript: NM_017490
Intron
Length: 101
Transcript: NM_017490
Length: 101
Transcript: NM_017490
Intron
Length: 77
Transcript: NM_017490
Length: 77
Transcript: NM_017490
Intron
Length: 1128
Transcript: NM_017490
Length: 1128
Transcript: NM_017490
Intron
Length: 273
Transcript: NM_017490
Length: 273
Transcript: NM_017490
Intron
Length: 278
Transcript: NM_017490
Length: 278
Transcript: NM_017490
Intron
Length: 827
Transcript: NM_017490
Length: 827
Transcript: NM_017490
Intron
Length: 638
Transcript: NM_017490
Length: 638
Transcript: NM_017490
Intron
Length: 3216
Transcript: NM_017490
Length: 3216
Transcript: NM_017490
Intron
Length: 572
Transcript: NM_017490
Length: 572
Transcript: NM_017490
Intron
Length: 40
Transcript: NM_017490
Length: 40
Transcript: NM_017490
Reaction
Expected peak: 274
15.1M
refseq_MARK2.F4
refseq_MARK2.R4
Expected peak: 274
15.1M
refseq_MARK2.F4
refseq_MARK2.R4
refseq_MARK2.R4
AGGCAACAGGGACACGCT
AGGCAACAGGGACACGCT
refseq_MARK2.F4
ACCAGCACAAATCGAAGCAG
ACCAGCACAAATCGAAGCAG