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Sequences

Sequence NM_005852

ATCTTTGTTTGGGTCTCCCATACTGCGTATAGATGAATGGGTCAGGATATCTGGAACAAAATATGGAGGTGAAGGGTGAGATCGGGAAACAAAGGGTATG
GCCCCCTAGTTCCCAAAGGGAGCAGGGAGATGGGAATAGAATTGAAGGTAGGTTTTAGGCTACTTGGGAGGAGGAATATTTAGGTAATTGTGGAGACTTT
CTCCTGTGTGATGAAGGCGGCAGACACTGTGATCCTGTGGGCAAGAAGTAAAAATGACCAGCTGAGGATTTCTTTTCCTCCAGGACTGTGTTGGGGTGAC
AGGATGCCTGATAAGGATGACATTCGGCTGCTGCCGTCAGCATTGGGTGTGAAGAAGAGAAAACGAGGACCCAAGAAGCAGAAGGAGAACAAGCCAGGAA
AACCCCGAAAACGCAAGAAGCGTGACAGTGAGGAGGAATTTGGTTCTGAGCGAGATGAGTACCGGGAGAAGTCAGAGAGTGGGGGCAGTGAATATGGAAC
CGGACCGGGTCGGAAACGAAGAAGGAAGCACCGAGAAAAAAAGGAGAAGAAGACAAAGCGGCGGAAAAAGGGGGAGGGAGATGGGGGGCAAAAGCAAGTG
GAACAGAAGTCATCAGCAACTCTGCTTCTGACCTGGGGCCTGGAGGATGTGGAGCATGTGTTCTCTGAGGAGGATTACCACACGCTCACCAACTACAAAG
CCTTCAGCCAGTTCATGAGGCCCCTAATTGCTAAGAAGAATCCTAAGATCCCAATGTCTAAGATGATGACCATCCTTGGGGCCAAATGGAGAGAGTTCAG
TGCCAACAACCCCTTCAAGGGGTCAGCAGCTGCTGTGGCGGCGGCAGCGGCAGCAGCAGCAGCAGCTGTAGCTGAGCAGGTGTCAGCTGCTGTCTCGTCG
GCCACCCCCATAGCACCCTCCGGACCCCCCGCCCTTCCACCACCCCCTGCTGCTGATATCCAGCCCCCACCCATCCGAAGAGCCAAAACCAAAGAGGGCA
AAGGTCCAGGCCATAAGAGGCGGAGTAAGAGCCCCCGAGTGCCTGATGGACGCAAGAAGCTTCGGGGAAAGAAAATGGCACCACTCAAAATAAAACTAGG
GCTTCTGGGTGGCAAGAGGAAGAAAGGAGGCTCGTATGTTTTTCAGAGCGACGAAGGTCCTGAACCAGAGGCTGAGGAATCAGACCTGGACAGTGGCAGT
GTCCACAGTGCCTCAGGCCGGCCTGATGGCCCTGTCCGCACCAAGAAACTAAAGAGAGGCCGGCCAGGAAGGAAGAAGAAGAAGGTCCTGGGCTGTCCTG
CAGTGGCCGGGGAGGAGGAGGTTGATGGCTACGAGACGGATCACCAGGATTACTGTGAGGTGTGCCAGCAGGGTGGGGAAATTATTCTGTGTGACACCTG
CCCTCGTGCCTACCACCTCGTCTGCCTTGATCCTGAGCTTGACCGGGCTCCAGAGGGCAAATGGAGCTGCCCTCACTGTGAGAAGGAGGGGGTCCAGTGG
GAGGCCAAGGAGGAAGAAGAAGAATACGAAGAGGAGGGAGAGGAAGAAGGGGAGAAGGAGGAGGAGGATGATCACATGGAGTACTGCCGCGTATGCAAGG
ACGGCGGGGAGCTCCTGTGCTGTGACGCGTGCATCTCCTCCTACCACATTCATTGTCTAAACCCTCCCCTGCCTGACATTCCCAATGGTGAATGGCTGTG
TCCCCGATGCACATGCCCCGTGCTGAAGGGTCGAGTGCAGAAGATCCTACATTGGCGGTGGGGGGAGCCACCTGTAGCAGTGCCAGCCCCTCAACAGGCA
GATGGAAATCCAGATGTCCCACCCCCCCGTCCTCTTCAAGGCAGATCAGAGCGAGAGTTCTTTGTCAAGTGGGTAGGACTATCCTACTGGCACTGCTCCT
GGGCCAAGGAGCTTCAGCTGGAAATCTTCCATTTGGTTATGTATCGAAACTACCAGCGGAAGAATGACATGGATGAGCCCCCACCCCTGGACTATGGCTC
CGGCGAGGATGATGGGAAGAGCGACAAGCGTAAAGTGAAAGACCCGCACTATGCTGAGATGGAGGAGAAGTACTATCGTTTTGGCATCAAGCCAGAGTGG
ATGACCGTCCACCGCATCATCAACCACAGTGTGGATAAAAAGGGGAATTACCACTATCTAGTAAAATGGAGGGACTTACCATATGACCAGTCCACGTGGG
AGGAAGATGAAATGAATATCCCTGAATACGAAGAACATAAGCAAAGCTACTGGAGACACCGAGAACTAATTATGGGGGAAGACCCTGCCCAGCCCCGCAA
GTATAAGAAGAAGAAGAAGGAGCTACAGGGTGATGGGCCTCCCAGTTCTCCCACTAATGATCCTACCGTGAAATATGAGACTCAGCCACGGTTTATCACA
GCCACTGGAGGCACCCTGCACATGTATCAGTTGGAAGGGCTGAACTGGCTACGCTTCTCCTGGGCCCAGGGCACTGACACCATTCTAGCTGATGAGATGG
GGCTAGGCAAGACCATACAAACCATCGTCTTCCTCTACTCACTCTACAAGGAGGGCCACACAAAAGGTCCCTTCCTGGTGAGTGCCCCACTCTCTACCAT
CATTAACTGGGAGCGGGAGTTCCAGATGTGGGCACCCAAATTCTATGTGGTGACATACACGGGTGACAAGGACAGCCGGGCCATCATTCGTGAGAATGAA
TTCTCCTTTGAGGACAATGCCATCAAAGGGGGCAAGAAAGCTTTTAAGATGAAGAGGGAGGCACAGGTGAAGTTCCATGTTCTCCTGACATCGTATGAGC
TGATCACCATTGATCAGGCAGCACTTGGTTCCATCCGCTGGGCCTGTCTTGTGGTAGATGAGGCCCATCGACTCAAGAACAACCAGTCCAAGTTTTTCAG
GGTTCTCAATGGTTACAAGATAGATCATAAGTTGCTGCTGACAGGAACCCCATTGCAGAATAATCTGGAGGAGCTCTTCCATCTCCTGAACTTCCTCACC
CCAGAGAGATTTAACAACTTGGAGGGCTTCCTGGAGGAGTTTGCTGACATATCCAAAGAGGACCAGATCAAGAAACTGCATGATTTGCTGGGGCCACACA
TGCTGCGGAGACTCAAGGCAGATGTCTTTAAGAACATGCCAGCCAAGACAGAGCTCATCGTTCGGGTGGAGCTAAGCCCCATGCAGAAGAAATACTACAA
ATACATCCTGACTCGAAATTTTGAGGCCTTGAATTCACGAGGTGGTGGGAACCAGGTGTCGCTGCTTAATATCATGATGGATCTTAAGAAGTGCTGCAAC
CATCCATACCTTTTTCCCGTGGCTGCTATGGAGTCCCCCAAACTCCCCAGTGGGGCTTATGAGGGTGGGGCACTTATTAAGTCGTCTGGGAAGCTCATGC
TGCTCCAGAAGATGCTGCGAAAGCTGAAGGAGCAAGGACACCGAGTGCTCATCTTCTCGCAGATGACCAAAATGTTAGACTTGCTTGAGGACTTCTTAGA
CTATGAAGGCTACAAGTATGAGCGCATCGATGGTGGTATCACGGGTGCCCTGAGGCAGGAGGCCATCGATCGGTTTAATGCTCCTGGGGCCCAACAATTC
TGCTTCCTCCTGTCCACCCGAGCTGGGGGCCTGGGCATCAATCTGGCCACTGCTGACACTGTCATCATCTTTGATTCTGACTGGAACCCCCATAATGACA
TCCAGGCCTTTAGCCGGGCTCATCGGATTGGCCAGGCCAACAAAGTGATGATTTACCGGTTTGTGACTCGCGCGTCAGTGGAAGAGCGAATCACACAAGT
GGCCAAGAGAAAGATGATGCTGACACACCTGGTTGTGCGGCCTGGGCTGGGCTCCAAGGCAGGCTCCATGTCCAAGCAGGAGCTTGACGACATTCTCAAA
TTTGGCACTGAAGAGCTATTCAAGGATGAAAACGAGGGGGAGAACAAGGAGGAGGACAGCAGTGTGATTCATTATGACAATGAGGCCATCGCTCGGCTGT
TGGACCGGAACCAGGATGCAACTGAGGACACTGACGTGCAGAACATGAATGAGTATCTCAGCTCCTTCAAGGTGGCACAGTACGTCGTGCGGGAAGAAGA
CAAGATTGAGGAAATTGAGCGAGAGATCATCAAGCAGGAGGAGAATGTGGACCCTGACTACTGGGAGAAGCTGCTGAGGCATCACTATGAGCAACAGCAG
GAAGACCTAGCCCGGAATCTAGGCAAGGGCAAGCGGGTTCGCAAGCAAGTTAACTACAATGATGCTGCTCAGGAAGACCAAGACAACCAGTCAGAGTACT
CGGTGGGTTCAGAGGAGGAGGATGAAGACTTCGATGAACGTCCTGAAGGGCGTAGACAGTCAAAGAGGCAGCTCCGGAATGAGAAAGATAAGCCACTGCC
TCCACTGCTGGCCCGAGTCGGGGGCAACATTGAGGTGCTGGGCTTCAACACCCGTCAGCGGAAGGCTTTCCTCAATGCTGTGATGCGCTGGGGGATGCCA
CCACAGGATGCCTTCACCACACAGTGGCTGGTGCGGGACCTGAGGGGCAAGACTGAGAAGGAGTTTAAGGCCTATGTGTCTTTGTTCATGCGCCATCTGT
GTGAGCCTGGGGCAGACGGCTCTGAAACCTTTGCCGATGGGGTCCCTCGGGAGGGACTGAGTCGCCAGCAGGTGTTGACCCGCATTGGAGTCATGTCTCT
CGTCAAAAAGAAGGTGCAGGAGTTTGAGCACATCAATGGGCGTTGGTCAATGCCGGAACTGATGCCTGACCCCAGCGCCGATTCTAAGCGCTCCTCCAGA
GCCTCCTCTCCTACCAAAACGTCTCCCACCACTCCTGAGGCTTCTGCTACCAACAGTCCCTGCACCTCTAAACCTGCTACTCCAGCTCCAAGTGAGAAAG
GAGAAGGCATAAGGACACCTCTTGAGAAGGAGGAAGCTGAAAACCAGGAGGAAAAGCCAGAGAAGAACAGCAGAATTGGGGAGAAGATGGAGACAGAGGC
TGATGCCCCCAGCCCAGCCCCATCACTTGGGGAGCGGCTGGAGCCAAGGAAGATTCCTCTAGAGGATGAGGTGCCAGGGGTGCCTGGAGAGATGGAGCCT
GAACCTGGGTACCGTGGGGACAGAGAGAAGTCAGAAGATGTAAAAGGTGACCGGGAGCTTCGACCAGGGCCTCGAGATGAGCCACGGTCCAATGGGCGAC
GAGAGGAAAAGACAGAGAAGCCCCGGTTCATGTTCAATATCGCCGATGGTGGCTTCACAGAGCTTCACACACTGTGGCAGAATGAGGAACGGGCAGCTAT
TTCCTCGGGGAAACTCAATGAGATCTGGCACAGAAGACATGACTATTGGCTTCTGGCTGGGATTGTCCTCCATGGCTATGCACGGTGGCAGGACATCCAG
AATGATGCTCAATTTGCCATTATCAACGAGCCATTTAAAACTGAAGCCAATAAGGGGAACTTTCTGGAGATGAAAAATAAGTTCCTGGCCCGGAGGTTCA
AGCTCCTGGAGCAGGCGCTGGTGATTGAGGAGCAGCTGCGGCGGGCGGCCTACCTGAACCTGTCGCAGGAGCCGGCGCACCCCGCCATGGCCCTCCACGC
CCGCTTCGCCGAGGCCGAGTGCCTGGCCGAGAGCCACCAGCACCTCTCCAAGGAGTCGCTGGCGGGGAACAAGCCGGCCAACGCCGTCCTGCACAAGGTT
CTGAACCAGCTGGAGGAGTTGCTGAGCGACATGAAGGCGGACGTGACCCGCCTGCCAGCCACGCTGTCCCGAATACCCCCCATCGCAGCCCGCCTTCAGA
TGTCCGAGCGCAGCATCCTCAGCCGGCTGGCCAGCAAGGGCACGGAGCCTCACCCCACACCGGCCTACCCGCCGGGTCCCTACGCTACACCTCCGGGGTA
CGGGGCGGCCTTCAGCGCCGCACCCGTAGGGGCCCTGGCCGCCGCAGGCGCCAATTACAGCCAGATGCCTGCAGGGTCCTTCATCACAGCCGCCACCAAC
GGCCCTCCAGTGCTTGTGAAGAAGGAGAAGGAAATGGTGGGGGCATTGGTGTCAGACGGGCTGGATCGGAAGGAGCCCCGAGCCGGGGAGGTGATCTGTA
TAGACGACTGACTGGATCCCAGGCCTGCCCTTCACCCAGGCCCCGTCCCCGAGGCCGACCCCCAGCTCAAGCGCTGGGGCCTGCTGCCAGCCCTCCACCT
TCCCCACCCCTTGGGCCATCACTGGGCTAGGAACCCCTTTGCCCCTCTCTGCAGCTCCTCTCTTCAAGAAGGGCCCTTTGTCTTTCTCCACTCCCACACA
CCTTTCCCACCAAGCCTTGAAGACTGTGCTGGTGAGAAGAAGTCTGGGTGGGAGATGGCTGGCAGGGTCTTCCAAGTACCTTCCTCCCACACTGCCAAGT
ATACACAACTTCCCAGTAAATGGTTGTGGGGAGGAAAGAGGTGGAGCCTCCCCAGCCGTTTCCCTGCAGAATCAGCTCTGTCTCATGTGGAAGTGGAGAA
TCAGCCTTGCCTGGCCTTTAGGAACTTTTGTGGGGAAGAGAGCTTTGAAGAGAGGAGGGGGACTTTAGAGAGGGATGAAAATGAGCCCTGGGAGGGAGGA
AGGGACGAGGAGGGGTGGCTGCATGTTACCGTCCCCTACCTCTCCCCACGTGGAGGGTGGAGCAGTTATGAGGGAGGAAGTCAACTGCTGTTCAGCCTCA
GAATAAAGGTGCCGTTCACTGGCTCAGTT
  • refseq_CHD3.F1 (forward primer)
  • refseq_CHD3.R1 (reverse primer)
  • Single exon skipping

Frame 0

IFVWVSHTAYR*MGQDIWNKIWR*RVRSGNKGY
GPLVPKGSREMGIELKVGFRLLGRRNI*VIVETF
SCVMKAADTVILWARSKNDQLRISFPPGLCWGD
RMPDKDDIRLLPSALGVKKRKRGPKKQKENKPG
KPRKRKKRDSEEEFGSERDEYREKSESGGSEYGT
GPGRKRRRKHREKKEKKTKRRKKGEGDGGQKQV
EQKSSATLLLTWGLEDVEHVFSEEDYHTLTNYK
AFSQFMRPLIAKKNPKIPMSKMMTILGAKWREFS
ANNPFKGSAAAVAAAAAAAAAAVAEQVSAAVSS
ATPIAPSGPPALPPPPAADIQPPPIRRAKTKEG
KGPGHKRRSKSPRVPDGRKKLRGKKMAPLKIKLG
LLGGKRKKGGSYVFQSDEGPEPEAEESDLDSGS
VHSASGRPDGPVRTKKLKRGRPGRKKKKVLGCP
AVAGEEEVDGYETDHQDYCEVCQQGGEIILCDTC
PRAYHLVCLDPELDRAPEGKWSCPHCEKEGVQW
EAKEEEEEYEEEGEEEGEKEEEDDHMEYCRVCK
DGGELLCCDACISSYHIHCLNPPLPDIPNGEWLC
PRCTCPVLKGRVQKILHWRWGEPPVAVPAPQQA
DGNPDVPPPRPLQGRSEREFFVKWVGLSYWHCS
WAKELQLEIFHLVMYRNYQRKNDMDEPPPLDYGS
GEDDGKSDKRKVKDPHYAEMEEKYYRFGIKPEW
MTVHRIINHSVDKKGNYHYLVKWRDLPYDQSTW
EEDEMNIPEYEEHKQSYWRHRELIMGEDPAQPRK
YKKKKKELQGDGPPSSPTNDPTVKYETQPRFIT
ATGGTLHMYQLEGLNWLRFSWAQGTDTILADEM
GLGKTIQTIVFLYSLYKEGHTKGPFLVSAPLSTI
INWEREFQMWAPKFYVVTYTGDKDSRAIIRENE
FSFEDNAIKGGKKAFKMKREAQVKFHVLLTSYE
LITIDQAALGSIRWACLVVDEAHRLKNNQSKFFR
VLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLT
PERFNNLEGFLEEFADISKEDQIKKLHDLLGPH
MLRRLKADVFKNMPAKTELIVRVELSPMQKKYYK
YILTRNFEALNSRGGGNQVSLLNIMMDLKKCCN
HPYLFPVAAMESPKLPSGAYEGGALIKSSGKLM
LLQKMLRKLKEQGHRVLIFSQMTKMLDLLEDFLD
YEGYKYERIDGGITGALRQEAIDRFNAPGAQQF
CFLLSTRAGGLGINLATADTVIIFDSDWNPHND
IQAFSRAHRIGQANKVMIYRFVTRASVEERITQV
AKRKMMLTHLVVRPGLGSKAGSMSKQELDDILK
FGTEELFKDENEGENKEEDSSVIHYDNEAIARL
LDRNQDATEDTDVQNMNEYLSSFKVAQYVVREED
KIEEIEREIIKQEENVDPDYWEKLLRHHYEQQQ
EDLARNLGKGKRVRKQVNYNDAAQEDQDNQSEY
SVGSEEEDEDFDERPEGRRQSKRQLRNEKDKPLP
PLLARVGGNIEVLGFNTRQRKAFLNAVMRWGMP
PQDAFTTQWLVRDLRGKTEKEFKAYVSLFMRHL
CEPGADGSETFADGVPREGLSRQQVLTRIGVMSL
VKKKVQEFEHINGRWSMPELMPDPSADSKRSSR
ASSPTKTSPTTPEASATNSPCTSKPATPAPSEK
GEGIRTPLEKEEAENQEEKPEKNSRIGEKMETEA
DAPSPAPSLGERLEPRKIPLEDEVPGVPGEMEP
EPGYRGDREKSEDVKGDRELRPGPRDEPRSNGR
REEKTEKPRFMFNIADGGFTELHTLWQNEERAAI
SSGKLNEIWHRRHDYWLLAGIVLHGYARWQDIQ
NDAQFAIINEPFKTEANKGNFLEMKNKFLARRF
KLLEQALVIEEQLRRAAYLNLSQEPAHPAMALHA
RFAEAECLAESHQHLSKESLAGNKPANAVLHKV
LNQLEELLSDMKADVTRLPATLSRIPPIAARLQ
MSERSILSRLASKGTEPHPTPAYPPGPYATPPGY
GAAFSAAPVGALAAAGANYSQMPAGSFITAATN
GPPVLVKKEKEMVGALVSDGLDRKEPRAGEVIC
IDD*LDPRPALHPGPVPEADPQLKRWGLLPALHL
PHPLGHHWARNPFAPLCSSSLQEGPFVFLHSHT
PFPPSLEDCAGEKKSGWEMAGRVFQVPSSHTAK
YTQLPSKWLWGGKRWSLPSRFPAESALSHVEVEN
QPCLAFRNFCGEESFEERRGTLERDENEPWEGG
RDEEGWLHVTVPYLSPRGGWSSYEGGSQLLFSL
RIKVPFTGSV

Frame 1

SLFGSPILRIDEWVRISGTKYGGEG*DRETKGM
AP*FPKGAGRWE*N*R*VLGYLGGGIFR*LWRL
SPV**RRQTL*SCGQEVKMTS*GFLFLQDCVGVT
GCLIRMTFGCCRQHWV*RRENEDPRSRRRTSQE
NPENARSVTVRRNLVLSEMSTGRSQRVGAVNME
PDRVGNEEGSTEKKRRRRQSGGKRGREMGGKSKW
NRSHQQLCF*PGAWRMWSMCSLRRITTRSPTTK
PSASS*GP*LLRRILRSQCLR**PSLGPNGESS
VPTTPSRGQQLLWRRQRQQQQQL*LSRCQLLSRR
PPP*HPPDPPPFHHPLLLISSPHPSEEPKPKRA
KVQAIRGGVRAPECLMDARSFGERKWHHSK*N*
GFWVARGRKEARMFFRATKVLNQRLRNQTWTVAV
STVPQAGLMALSAPRN*REAGQEGRRRRSWAVL
QWPGRRRLMATRRITRITVRCASRVGKLFCVTP
ALVPTTSSALILSLTGLQRANGAALTVRRRGSSG
RPRRKKKNTKRRERKKGRRRRRMITWSTAAYAR
TAGSSCAVTRASPPTTFIV*TLPCLTFPMVNGC
VPDAHAPC*RVECRRSYIGGGGSHL*QCQPLNRQ
MEIQMSHPPVLFKADQSESSLSSG*DYPTGTAP
GPRSFSWKSSIWLCIETTSGRMTWMSPHPWTMA
PARMMGRATSVK*KTRTMLRWRRSTIVLASSQSG
*PSTASSTTVWIKRGITTI**NGGTYHMTSPRG
RKMK*ISLNTKNISKATGDTEN*LWGKTLPSPA
SIRRRRRSYRVMGLPVLPLMILP*NMRLSHGLSQ
PLEAPCTCISWKG*TGYASPGPRALTPF*LMRW
G*ARPYKPSSSSTHSTRRATQKVPSW*VPHSLP
SLTGSGSSRCGHPNSMW*HTRVTRTAGPSFVRMN
SPLRTMPSKGARKLLR*RGRHR*SSMFS*HRMS
*SPLIRQHLVPSAGPVLW*MRPIDSRTTSPSFS
GFSMVTR*IISCC*QEPHCRIIWRSSSIS*TSSP
QRDLTTWRASWRSLLTYPKRTRSRNCMICWGHT
CCGDSRQMSLRTCQPRQSSSFGWS*APCRRNTT
NTS*LEILRP*IHEVVGTRCRCLIS*WILRSAAT
IHTFFPWLLWSPPNSPVGLMRVGHLLSRLGSSC
CSRRCCES*RSKDTECSSSRR*PKC*TCLRTS*
TMKATSMSASMVVSRVP*GRRPSIGLMLLGPNNS
ASSCPPELGAWASIWPLLTLSSSLILTGTPIMT
SRPLAGLIGLARPTK**FTGL*LARQWKSESHK
WPRER*C*HTWLCGLGWAPRQAPCPSRSLTTFSN
LALKSYSRMKTRGRTRRRTAV*FIMTMRPSLGC
WTGTRMQLRTLTCRT*MSISAPSRWHSTSCGKK
TRLRKLSERSSSRRRMWTLTTGRSC*GITMSNSR
KT*PGI*ARASGFASKLTTMMLLRKTKTTSQST
RWVQRRRMKTSMNVLKGVDSQRGSSGMRKISHC
LHCWPESGATLRCWASTPVSGRLSSML*CAGGCH
HRMPSPHSGWCGT*GARLRRSLRPMCLCSCAIC
VSLGQTALKPLPMGSLGRD*VASRC*PALESCL
SSKRRCRSLSTSMGVGQCRN*CLTPAPILSAPPE
PPLLPKRLPPLLRLLLPTVPAPLNLLLQLQVRK
EKA*GHLLRRRKLKTRRKSQRRTAELGRRWRQR
LMPPAQPHHLGSGWSQGRFL*RMRCQGCLERWSL
NLGTVGTERSQKM*KVTGSFDQGLEMSHGPMGD
ERKRQRSPGSCSISPMVASQSFTHCGRMRNGQL
FPRGNSMRSGTEDMTIGFWLGLSSMAMHGGRTSR
MMLNLPLSTSHLKLKPIRGTFWR*KISSWPGGS
SSWSRRW*LRSSCGGRPT*TCRRSRRTPPWPST
PASPRPSAWPRATSTSPRSRWRGTSRPTPSCTRF
*TSWRSC*AT*RRT*PACQPRCPEYPPSQPAFR
CPSAASSAGWPARARSLTPHRPTRRVPTLHLRG
TGRPSAPHP*GPWPPQAPITARCLQGPSSQPPPT
ALQCL*RRRRKWWGHWCQTGWIGRSPEPGR*SV
*TTDWIPGLPFTQAPSPRPTPSSSAGACCQPST
FPTPWAITGLGTPLPLSAAPLFKKGPLSFSTPTH
LSHQALKTVLVRRSLGGRWLAGSSKYLPPTLPS
IHNFPVNGCGEERGGASPAVSLQNQLCLMWKWR
ISLAWPLGTFVGKRALKRGGGL*RGMKMSPGREE
GTRRGGCMLPSPTSPHVEGGAVMREEVNCCSAS
E*RCRSLAQ

Frame 2

LCLGLPYCV*MNGSGYLEQNMEVKGEIGKQRVW
PPSSQREQGDGNRIEGRF*ATWEEEYLGNCGDF
LLCDEGGRHCDPVGKK*K*PAEDFFSSRTVLG*
QDA**G*HSAAAVSIGCEEEKTRTQEAEGEQARK
TPKTQEA*Q*GGIWF*AR*VPGEVREWGQ*IWN
RTGSETKKEAPRKKGEEDKAAEKGGGRWGAKAS
GTEVISNSASDLGPGGCGACVL*GGLPHAHQLQS
LQPVHEAPNC*EES*DPNV*DDDHPWGQMERVQ
CQQPLQGVSSCCGGGSGSSSSSCS*AGVSCCLV
GHPHSTLRTPRPSTTPCC*YPAPTHPKSQNQRGQ
RSRP*EAE*EPPSA*WTQEASGKENGTTQNKTR
ASGWQEEERRLVCFSERRRS*TRG*GIRPGQWQ
CPQCLRPA*WPCPHQETKERPARKEEEEGPGLSC
SGRGGGG*WLRDGSPGLL*GVPAGWGNYSV*HL
PSCLPPRLP*S*A*PGSRGQMELPSL*EGGGPV
GGQGGRRRIRRGGRGRRGEGGGG*SHGVLPRMQG
RRGAPVL*RVHLLLPHSLSKPSPA*HSQW*MAV
SPMHMPRAEGSSAEDPTLAVGGATCSSASPSTG
RWKSRCPTPPSSSRQIRARVLCQVGRTILLALLL
GQGASAGNLPFGYVSKLPAEE*HG*APTPGLWL
RRG*WEERQA*SERPALC*DGGEVLSFWHQARV
DDRPPHHQPQCG*KGELPLSSKMEGLTI*PVHVG
GR*NEYP*IRRT*AKLLETPRTNYGGRPCPAPQ
V*EEEEGATG*WASQFSH**SYREI*DSATVYH
SHWRHPAHVSVGRAELATLLLGPGH*HHSS**DG
ARQDHTNHRLPLLTLQGGPHKRSLPGECPTLYH
H*LGAGVPDVGTQILCGDIHG*QGQPGHHS*E*
ILL*GQCHQRGQESF*DEEGGTGEVPCSPDIV*A
DHH*SGSTWFHPLGLSCGR*GPSTQEQPVQVFQ
GSQWLQDRS*VAADRNPIAE*SGGALPSPELPH
PREI*QLGGLPGGVC*HIQRGPDQETA*FAGATH
AAETQGRCL*EHASQDRAHRSGGAKPHAEEILQ
IHPDSKF*GLEFTRWWEPGVAA*YHDGS*EVLQ
PSIPFSRGCYGVPQTPQWGL*GWGTY*VVWEAHA
APEDAAKAEGARTPSAHLLADDQNVRLA*GLLR
L*RLQV*AHRWWYHGCPEAGGHRSV*CSWGPTI
LLPPVHPSWGPGHQSGHC*HCHHL*F*LEPP**H
PGL*PGSSDWPGQQSDDLPVCDSRVSGRANHTS
GQEKDDADTPGCAAWAGLQGRLHVQAGA*RHSQ
IWH*RAIQG*KRGGEQGGGQQCDSL*Q*GHRSAV
GPEPGCN*GH*RAEHE*VSQLLQGGTVRRAGRR
QD*GN*ARDHQAGGECGP*LLGEAAEASL*ATA
GRPSPESRQGQAGSQAS*LQ*CCSGRPRQPVRVL
GGFRGGG*RLR*TS*RA*TVKEAAPE*ER*ATA
STAGPSRGQH*GAGLQHPSAEGFPQCCDALGDA
TTGCLHHTVAGAGPEGQD*EGV*GLCVFVHAPSV
*AWGRRL*NLCRWGPSGGTESPAGVDPHWSHVS
RQKEGAGV*AHQWALVNAGTDA*PQRRF*ALLQ
SLLSYQNVSHHS*GFCYQQSLHL*TCYSSSK*ER
RRHKDTS*EGGS*KPGGKAREEQQNWGEDGDRG
*CPQPSPITWGAAGAKEDSSRG*GARGAWRDGA
*TWVPWGQREVRRCKR*PGASTRASR*ATVQWAT
RGKDREAPVHVQYRRWWLHRASHTVAE*GTGSY
FLGETQ*DLAQKT*LLASGWDCPPWLCTVAGHP
E*CSICHYQRAI*N*SQ*GELSGDEK*VPGPEVQ
APGAGAGD*GAAAAGGLPEPVAGAGAPRHGPPR
PLRRGRVPGREPPAPLQGVAGGEQAGQRRPAQG
SEPAGGVAERHEGGRDPPASHAVPNTPHRSPPSD
VRAQHPQPAGQQGHGASPHTGLPAGSLRYTSGV
RGGLQRRTRRGPGRRRRQLQPDACRVLHHSRHQ
RPSSACEEGEGNGGGIGVRRAGSEGAPSRGGDLY
RRLTGSQACPSPRPRPRGRPPAQALGPAASPPP
SPPLGPSLG*EPLCPSLQLLSSRRALCLSPLPH
TFPTKP*RLCW*EEVWVGDGWQGLPSTFLPHCQV
YTTSQ*MVVGRKEVEPPQPFPCRISSVSCGSGE
SALPGL*ELLWGREL*REEGDFREG*K*ALGGR
KGRGGVAACYRPLPLPTWRVEQL*GRKSTAVQPQ
NKGAVHWLS

Sequence NM_001005271

GATGGCTTCCCCTCTGAGGGACGAGGAGGAGGAGGAGGAGGAGATGGTGGTGTCGGAGGAGGAAGAAGAGGAGGAAGAAGAGGGCGACGAGGAGGAGGAG
GAGGAGGTGGAGGCGGCCGACGAGGACGATGAGGAGGACGACGACGAGGGAGTACTCGGGCGCGGGCCGGGCCACGACCGGGGCCGCGACCGCCACAGCC
CCCCCGGCTGCCACCTCTTCCCGCCGCCGCCGCCGCCGCCGCCACCGCTGCCCCCGCCGCCGCCGCCCCCGCCGCCAGATAAGGATGACATTCGGCTGCT
GCCGTCAGCATTGGGTGTGAAGAAGAGAAAACGAGGACCCAAGAAGCAGAAGGAGAACAAGCCAGGAAAACCCCGAAAACGCAAGAAGCGTGACAGTGAG
GAGGAATTTGGTTCTGAGCGAGATGAGTACCGGGAGAAGTCAGAGAGTGGGGGCAGTGAATATGGAACCGGACCGGGTCGGAAACGAAGAAGGAAGCACC
GAGAAAAAAAGGAGAAGAAGACAAAGCGGCGGAAAAAGGGGGAGGGAGATGGGGGGCAAAAGCAAGTGGAACAGAAGTCATCAGCAACTCTGCTTCTGAC
CTGGGGCCTGGAGGATGTGGAGCATGTGTTCTCTGAGGAGGATTACCACACGCTCACCAACTACAAAGCCTTCAGCCAGTTCATGAGGCCCCTAATTGCT
AAGAAGAATCCTAAGATCCCAATGTCTAAGATGATGACCATCCTTGGGGCCAAATGGAGAGAGTTCAGTGCCAACAACCCCTTCAAGGGGTCAGCAGCTG
CTGTGGCGGCGGCAGCGGCAGCAGCAGCAGCAGCTGTAGCTGAGCAGGTGTCAGCTGCTGTCTCGTCGGCCACCCCCATAGCACCCTCCGGACCCCCCGC
CCTTCCACCACCCCCTGCTGCTGATATCCAGCCCCCACCCATCCGAAGAGCCAAAACCAAAGAGGGCAAAGGTCCAGGCCATAAGAGGCGGAGTAAGAGC
CCCCGAGTGCCTGATGGACGCAAGAAGCTTCGGGGAAAGAAAATGGCACCACTCAAAATAAAACTAGGGCTTCTGGGTGGCAAGAGGAAGAAAGGAGGCT
CGTATGTTTTTCAGAGCGACGAAGGTCCTGAACCAGAGGCTGAGGAATCAGACCTGGACAGTGGCAGTGTCCACAGTGCCTCAGGCCGGCCTGATGGCCC
TGTCCGCACCAAGAAACTAAAGAGAGGCCGGCCAGGAAGGAAGAAGAAGAAGGTCCTGGGCTGTCCTGCAGTGGCCGGGGAGGAGGAGGTTGATGGCTAC
GAGACGGATCACCAGGATTACTGTGAGGTGTGCCAGCAGGGTGGGGAAATTATTCTGTGTGACACCTGCCCTCGTGCCTACCACCTCGTCTGCCTTGATC
CTGAGCTTGACCGGGCTCCAGAGGGCAAATGGAGCTGCCCTCACTGTGAGAAGGAGGGGGTCCAGTGGGAGGCCAAGGAGGAAGAAGAAGAATACGAAGA
GGAGGGAGAGGAAGAAGGGGAGAAGGAGGAGGAGGATGATCACATGGAGTACTGCCGCGTATGCAAGGACGGCGGGGAGCTCCTGTGCTGTGACGCGTGC
ATCTCCTCCTACCACATTCATTGTCTAAACCCTCCCCTGCCTGACATTCCCAATGGTGAATGGCTGTGTCCCCGATGCACATGCCCCGTGCTGAAGGGTC
GAGTGCAGAAGATCCTACATTGGCGGTGGGGGGAGCCACCTGTAGCAGTGCCAGCCCCTCAACAGGCAGATGGAAATCCAGATGTCCCACCCCCCCGTCC
TCTTCAAGGCAGATCAGAGCGAGAGTTCTTTGTCAAGTGGGTAGGACTATCCTACTGGCACTGCTCCTGGGCCAAGGAGCTTCAGCTGGAAATCTTCCAT
TTGGTTATGTATCGAAACTACCAGCGGAAGAATGACATGGATGAGCCCCCACCCCTGGACTATGGCTCCGGCGAGGATGATGGGAAGAGCGACAAGCGTA
AAGTGAAAGACCCGCACTATGCTGAGATGGAGGAGAAGTACTATCGTTTTGGCATCAAGCCAGAGTGGATGACCGTCCACCGCATCATCAACCACAGTGT
GGATAAAAAGGGGAATTACCACTATCTAGTAAAATGGAGGGACTTACCATATGACCAGTCCACGTGGGAGGAAGATGAAATGAATATCCCTGAATACGAA
GAACATAAGCAAAGCTACTGGAGACACCGAGAACTAATTATGGGGGAAGACCCTGCCCAGCCCCGCAAGTATAAGAAGAAGAAGAAGGAGCTACAGGGTG
ATGGGCCTCCCAGTTCTCCCACTAATGATCCTACCGTGAAATATGAGACTCAGCCACGGTTTATCACAGCCACTGGAGGCACCCTGCACATGTATCAGTT
GGAAGGGCTGAACTGGCTACGCTTCTCCTGGGCCCAGGGCACTGACACCATTCTAGCTGATGAGATGGGGCTAGGCAAGACCATACAAACCATCGTCTTC
CTCTACTCACTCTACAAGGAGGGCCACACAAAAGGTCCCTTCCTGGTGAGTGCCCCACTCTCTACCATCATTAACTGGGAGCGGGAGTTCCAGATGTGGG
CACCCAAATTCTATGTGGTGACATACACGGGTGACAAGGACAGCCGGGCCATCATTCGTGAGAATGAATTCTCCTTTGAGGACAATGCCATCAAAGGGGG
CAAGAAAGCTTTTAAGATGAAGAGGGAGGCACAGGTGAAGTTCCATGTTCTCCTGACATCGTATGAGCTGATCACCATTGATCAGGCAGCACTTGGTTCC
ATCCGCTGGGCCTGTCTTGTGGTAGATGAGGCCCATCGACTCAAGAACAACCAGTCCAAGTTTTTCAGGGTTCTCAATGGTTACAAGATAGATCATAAGT
TGCTGCTGACAGGAACCCCATTGCAGAATAATCTGGAGGAGCTCTTCCATCTCCTGAACTTCCTCACCCCAGAGAGATTTAACAACTTGGAGGGCTTCCT
GGAGGAGTTTGCTGACATATCCAAAGAGGACCAGATCAAGAAACTGCATGATTTGCTGGGGCCACACATGCTGCGGAGACTCAAGGCAGATGTCTTTAAG
AACATGCCAGCCAAGACAGAGCTCATCGTTCGGGTGGAGCTAAGCCCCATGCAGAAGAAATACTACAAATACATCCTGACTCGAAATTTTGAGGCCTTGA
ATTCACGAGGTGGTGGGAACCAGGTGTCGCTGCTTAATATCATGATGGATCTTAAGAAGTGCTGCAACCATCCATACCTTTTTCCCGTGGCTGCTATGGA
GTCCCCCAAACTCCCCAGTGGGGCTTATGAGGGTGGGGCACTTATTAAGTCGTCTGGGAAGCTCATGCTGCTCCAGAAGATGCTGCGAAAGCTGAAGGAG
CAAGGACACCGAGTGCTCATCTTCTCGCAGATGACCAAAATGTTAGACTTGCTTGAGGACTTCTTAGACTATGAAGGCTACAAGTATGAGCGCATCGATG
GTGGTATCACGGGTGCCCTGAGGCAGGAGGCCATCGATCGGTTTAATGCTCCTGGGGCCCAACAATTCTGCTTCCTCCTGTCCACCCGAGCTGGGGGCCT
GGGCATCAATCTGGCCACTGCTGACACTGTCATCATCTTTGATTCTGACTGGAACCCCCATAATGACATCCAGGCCTTTAGCCGGGCTCATCGGATTGGC
CAGGCCAACAAAGTGATGATTTACCGGTTTGTGACTCGCGCGTCAGTGGAAGAGCGAATCACACAAGTGGCCAAGAGAAAGATGATGCTGACACACCTGG
TTGTGCGGCCTGGGCTGGGCTCCAAGGCAGGCTCCATGTCCAAGCAGGAGCTTGACGACATTCTCAAATTTGGCACTGAAGAGCTATTCAAGGATGAAAA
CGAGGGGGAGAACAAGGAGGAGGACAGCAGTGTGATTCATTATGACAATGAGGCCATCGCTCGGCTGTTGGACCGGAACCAGGATGCAACTGAGGACACT
GACGTGCAGAACATGAATGAGTATCTCAGCTCCTTCAAGGTGGCACAGTACGTCGTGCGGGAAGAAGACAAGATTGAGGAAATTGAGCGAGAGATCATCA
AGCAGGAGGAGAATGTGGACCCTGACTACTGGGAGAAGCTGCTGAGGCATCACTATGAGCAACAGCAGGAAGACCTAGCCCGGAATCTAGGCAAGGGCAA
GCGGGTTCGCAAGCAAGTTAACTACAATGATGCTGCTCAGGAAGACCAAGACAACCAGTCAGAGTACTCGGTGGGTTCAGAGGAGGAGGATGAAGACTTC
GATGAACGTCCTGAAGGGCGTAGACAGTCAAAGAGGCAGCTCCGGAATGAGAAAGATAAGCCACTGCCTCCACTGCTGGCCCGAGTCGGGGGCAACATTG
AGGTGCTGGGCTTCAACACCCGTCAGCGGAAGGCTTTCCTCAATGCTGTGATGCGCTGGGGGATGCCACCACAGGATGCCTTCACCACACAGTGGCTGGT
GCGGGACCTGAGGGGCAAGACTGAGAAGGAGTTTAAGGCCTATGTGTCTTTGTTCATGCGCCATCTGTGTGAGCCTGGGGCAGACGGCTCTGAAACCTTT
GCCGATGGGGTCCCTCGGGAGGGACTGAGTCGCCAGCAGGTGTTGACCCGCATTGGAGTCATGTCTCTCGTCAAAAAGAAGGTGCAGGAGTTTGAGCACA
TCAATGGGCGTTGGTCAATGCCGGAACTGATGCCTGACCCCAGCGCCGATTCTAAGCGCTCCTCCAGAGCCTCCTCTCCTACCAAAACGTCTCCCACCAC
TCCTGAGGCTTCTGCTACCAACAGTCCCTGCACCTCTAAACCTGCTACTCCAGCTCCAAGTGAGAAAGGAGAAGGCATAAGGACACCTCTTGAGAAGGAG
GAAGCTGAAAACCAGGAGGAAAAGCCAGAGAAGAACAGCAGAATTGGGGAGAAGATGGAGACAGAGGCTGATGCCCCCAGCCCAGCCCCATCACTTGGGG
AGCGGCTGGAGCCAAGGAAGATTCCTCTAGAGGATGAGGTGCCAGGGGTGCCTGGAGAGATGGAGCCTGAACCTGGGTACCGTGGGGACAGAGAGAAGTC
AGCCACAGAGTCGACGCCAGGAGAAAGGGGGGAGGAGAAGCCGTTGGATGGACAGGAACACAGGGAGAGGCCGGAGGGGGAAACAGGGGATTTGGGCAAG
AGAGAAGATGTAAAAGGTGACCGGGAGCTTCGACCAGGGCCTCGAGATGAGCCACGGTCCAATGGGCGACGAGAGGAAAAGACAGAGAAGCCCCGGTTCA
TGTTCAATATCGCCGATGGTGGCTTCACAGAGCTTCACACACTGTGGCAGAATGAGGAACGGGCAGCTATTTCCTCGGGGAAACTCAATGAGATCTGGCA
CAGAAGACATGACTATTGGCTTCTGGCTGGGATTGTCCTCCATGGCTATGCACGGTGGCAGGACATCCAGAATGATGCTCAATTTGCCATTATCAACGAG
CCATTTAAAACTGAAGCCAATAAGGGGAACTTTCTGGAGATGAAAAATAAGTTCCTGGCCCGGAGGTTCAAGCTCCTGGAGCAGGCGCTGGTGATTGAGG
AGCAGCTGCGGCGGGCGGCCTACCTGAACCTGTCGCAGGAGCCGGCGCACCCCGCCATGGCCCTCCACGCCCGCTTCGCCGAGGCCGAGTGCCTGGCCGA
GAGCCACCAGCACCTCTCCAAGGAGTCGCTGGCGGGGAACAAGCCGGCCAACGCCGTCCTGCACAAGGTTCTGAACCAGCTGGAGGAGTTGCTGAGCGAC
ATGAAGGCGGACGTGACCCGCCTGCCAGCCACGCTGTCCCGAATACCCCCCATCGCAGCCCGCCTTCAGATGTCCGAGCGCAGCATCCTCAGCCGGCTGG
CCAGCAAGGGCACGGAGCCTCACCCCACACCGGCCTACCCGCCGGGTCCCTACGCTACACCTCCGGGGTACGGGGCGGCCTTCAGCGCCGCACCCGTAGG
GGCCCTGGCCGCCGCAGGCGCCAATTACAGCCAGATGCCTGCAGGGTCCTTCATCACAGCCGCCACCAACGGCCCTCCAGTGCTTGTGAAGAAGGAGAAG
GAAATGGTGGGGGCATTGGTGTCAGACGGGCTGGATCGGAAGGAGCCCCGAGCCGGGGAGGTGATCTGTATAGACGACTGACTGGATCCCAGGCCTGCCC
TTCACCCAGGCCCCGTCCCCGAGGCCGACCCCCAGCTCAAGCGCTGGGGCCTGCTGCCAGCCCTCCACCTTCCCCACCCCTTGGGCCATCACTGGGCTAG
GAACCCCTTTGCCCCTCTCTGCAGCTCCTCTCTTCAAGAAGGGCCCTTTGTCTTTCTCCACTCCCACACACCTTTCCCACCAAGCCTTGAAGACTGTGCT
GGTGAGAAGAAGTCTGGGTGGGAGATGGCTGGCAGGGTCTTCCAAGTACCTTCCTCCCACACTGCCAAGTATACACAACTTCCCAGTAAATGGTTGTGGG
GAGGAAAGAGGTGGAGCCTCCCCAGCCGTTTCCCTGCAGAATCAGCTCTGTCTCATGTGGAAGTGGAGAATCAGCCTTGCCTGGCCTTTAGGAACTTTTG
TGGGGAAGAGAGCTTTGAAGAGAGGAGGGGGACTTTAGAGAGGGATGAAAATGAGCCCTGGGAGGGAGGAAGGGACGAGGAGGGGTGGCTGCATGTTACC
GTCCCCTACCTCTCCCCACGTGGAGGGTGGAGCAGTTATGAGGGAGGAAGTCAACTGCTGTTCAGCCTCAGAATAAAGGTGCCGTTCACTGGCTCAGTT
  • refseq_CHD3.F1 (forward primer)
  • refseq_CHD3.R1 (reverse primer)
  • Single exon skipping

Frame 0

DGFPSEGRGGGGGGDGGVGGGRRGGRRGRRGGG
GGGGGGRRGR*GGRRRGSTRARAGPRPGPRPPQP
PRLPPLPAAAAAAATAAPAAAAPAAR*G*HSAA
AVSIGCEEEKTRTQEAEGEQARKTPKTQEA*Q*
GGIWF*AR*VPGEVREWGQ*IWNRTGSETKKEAP
RKKGEEDKAAEKGGGRWGAKASGTEVISNSASD
LGPGGCGACVL*GGLPHAHQLQSLQPVHEAPNC
*EES*DPNV*DDDHPWGQMERVQCQQPLQGVSSC
CGGGSGSSSSSCS*AGVSCCLVGHPHSTLRTPR
PSTTPCC*YPAPTHPKSQNQRGQRSRP*EAE*E
PPSA*WTQEASGKENGTTQNKTRASGWQEEERRL
VCFSERRRS*TRG*GIRPGQWQCPQCLRPA*WP
CPHQETKERPARKEEEEGPGLSCSGRGGGG*WL
RDGSPGLL*GVPAGWGNYSV*HLPSCLPPRLP*S
*A*PGSRGQMELPSL*EGGGPVGGQGGRRRIRR
GGRGRRGEGGGG*SHGVLPRMQGRRGAPVL*RV
HLLLPHSLSKPSPA*HSQW*MAVSPMHMPRAEGS
SAEDPTLAVGGATCSSASPSTGRWKSRCPTPPS
SSRQIRARVLCQVGRTILLALLLGQGASAGNLP
FGYVSKLPAEE*HG*APTPGLWLRRG*WEERQA*
SERPALC*DGGEVLSFWHQARVDDRPPHHQPQC
G*KGELPLSSKMEGLTI*PVHVGGR*NEYP*IR
RT*AKLLETPRTNYGGRPCPAPQV*EEEEGATG*
WASQFSH**SYREI*DSATVYHSHWRHPAHVSV
GRAELATLLLGPGH*HHSS**DGARQDHTNHRL
PLLTLQGGPHKRSLPGECPTLYHH*LGAGVPDVG
TQILCGDIHG*QGQPGHHS*E*ILL*GQCHQRG
QESF*DEEGGTGEVPCSPDIV*ADHH*SGSTWF
HPLGLSCGR*GPSTQEQPVQVFQGSQWLQDRS*V
AADRNPIAE*SGGALPSPELPHPREI*QLGGLP
GGVC*HIQRGPDQETA*FAGATHAAETQGRCL*
EHASQDRAHRSGGAKPHAEEILQIHPDSKF*GLE
FTRWWEPGVAA*YHDGS*EVLQPSIPFSRGCYG
VPQTPQWGL*GWGTY*VVWEAHAAPEDAAKAEG
ARTPSAHLLADDQNVRLA*GLLRL*RLQV*AHRW
WYHGCPEAGGHRSV*CSWGPTILLPPVHPSWGP
GHQSGHC*HCHHL*F*LEPP**HPGL*PGSSDW
PGQQSDDLPVCDSRVSGRANHTSGQEKDDADTPG
CAAWAGLQGRLHVQAGA*RHSQIWH*RAIQG*K
RGGEQGGGQQCDSL*Q*GHRSAVGPEPGCN*GH
*RAEHE*VSQLLQGGTVRRAGRRQD*GN*ARDHQ
AGGECGP*LLGEAAEASL*ATAGRPSPESRQGQ
AGSQAS*LQ*CCSGRPRQPVRVLGGFRGGG*RL
R*TS*RA*TVKEAAPE*ER*ATASTAGPSRGQH*
GAGLQHPSAEGFPQCCDALGDATTGCLHHTVAG
AGPEGQD*EGV*GLCVFVHAPSV*AWGRRL*NL
CRWGPSGGTESPAGVDPHWSHVSRQKEGAGV*AH
QWALVNAGTDA*PQRRF*ALLQSLLSYQNVSHH
S*GFCYQQSLHL*TCYSSSK*ERRRHKDTS*EG
GS*KPGGKAREEQQNWGEDGDRG*CPQPSPITWG
AAGAKEDSSRG*GARGAWRDGA*TWVPWGQREV
SHRVDARRKGGGEAVGWTGTQGEAGGGNRGFGQ
ERRCKR*PGASTRASR*ATVQWATRGKDREAPVH
VQYRRWWLHRASHTVAE*GTGSYFLGETQ*DLA
QKT*LLASGWDCPPWLCTVAGHPE*CSICHYQR
AI*N*SQ*GELSGDEK*VPGPEVQAPGAGAGD*G
AAAAGGLPEPVAGAGAPRHGPPRPLRRGRVPGR
EPPAPLQGVAGGEQAGQRRPAQGSEPAGGVAER
HEGGRDPPASHAVPNTPHRSPPSDVRAQHPQPAG
QQGHGASPHTGLPAGSLRYTSGVRGGLQRRTRR
GPGRRRRQLQPDACRVLHHSRHQRPSSACEEGE
GNGGGIGVRRAGSEGAPSRGGDLYRRLTGSQACP
SPRPRPRGRPPAQALGPAASPPPSPPLGPSLG*
EPLCPSLQLLSSRRALCLSPLPHTFPTKP*RLC
W*EEVWVGDGWQGLPSTFLPHCQVYTTSQ*MVVG
RKEVEPPQPFPCRISSVSCGSGESALPGL*ELL
WGREL*REEGDFREG*K*ALGGRKGRGGVAACY
RPLPLPTWRVEQL*GRKSTAVQPQNKGAVHWLS

Frame 1

MASPLRDEEEEEEEMVVSEEEEEEEEEGDEEEE
EEVEAADEDDEEDDDEGVLGRGPGHDRGRDRHS
PPGCHLFPPPPPPPPPLPPPPPPPPPDKDDIRLL
PSALGVKKRKRGPKKQKENKPGKPRKRKKRDSE
EEFGSERDEYREKSESGGSEYGTGPGRKRRRKH
REKKEKKTKRRKKGEGDGGQKQVEQKSSATLLLT
WGLEDVEHVFSEEDYHTLTNYKAFSQFMRPLIA
KKNPKIPMSKMMTILGAKWREFSANNPFKGSAA
AVAAAAAAAAAAVAEQVSAAVSSATPIAPSGPPA
LPPPPAADIQPPPIRRAKTKEGKGPGHKRRSKS
PRVPDGRKKLRGKKMAPLKIKLGLLGGKRKKGG
SYVFQSDEGPEPEAEESDLDSGSVHSASGRPDGP
VRTKKLKRGRPGRKKKKVLGCPAVAGEEEVDGY
ETDHQDYCEVCQQGGEIILCDTCPRAYHLVCLD
PELDRAPEGKWSCPHCEKEGVQWEAKEEEEEYEE
EGEEEGEKEEEDDHMEYCRVCKDGGELLCCDAC
ISSYHIHCLNPPLPDIPNGEWLCPRCTCPVLKG
RVQKILHWRWGEPPVAVPAPQQADGNPDVPPPRP
LQGRSEREFFVKWVGLSYWHCSWAKELQLEIFH
LVMYRNYQRKNDMDEPPPLDYGSGEDDGKSDKR
KVKDPHYAEMEEKYYRFGIKPEWMTVHRIINHSV
DKKGNYHYLVKWRDLPYDQSTWEEDEMNIPEYE
EHKQSYWRHRELIMGEDPAQPRKYKKKKKELQG
DGPPSSPTNDPTVKYETQPRFITATGGTLHMYQL
EGLNWLRFSWAQGTDTILADEMGLGKTIQTIVF
LYSLYKEGHTKGPFLVSAPLSTIINWEREFQMW
APKFYVVTYTGDKDSRAIIRENEFSFEDNAIKGG
KKAFKMKREAQVKFHVLLTSYELITIDQAALGS
IRWACLVVDEAHRLKNNQSKFFRVLNGYKIDHK
LLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFL
EEFADISKEDQIKKLHDLLGPHMLRRLKADVFK
NMPAKTELIVRVELSPMQKKYYKYILTRNFEAL
NSRGGGNQVSLLNIMMDLKKCCNHPYLFPVAAME
SPKLPSGAYEGGALIKSSGKLMLLQKMLRKLKE
QGHRVLIFSQMTKMLDLLEDFLDYEGYKYERID
GGITGALRQEAIDRFNAPGAQQFCFLLSTRAGGL
GINLATADTVIIFDSDWNPHNDIQAFSRAHRIG
QANKVMIYRFVTRASVEERITQVAKRKMMLTHL
VVRPGLGSKAGSMSKQELDDILKFGTEELFKDEN
EGENKEEDSSVIHYDNEAIARLLDRNQDATEDT
DVQNMNEYLSSFKVAQYVVREEDKIEEIEREII
KQEENVDPDYWEKLLRHHYEQQQEDLARNLGKGK
RVRKQVNYNDAAQEDQDNQSEYSVGSEEEDEDF
DERPEGRRQSKRQLRNEKDKPLPPLLARVGGNI
EVLGFNTRQRKAFLNAVMRWGMPPQDAFTTQWLV
RDLRGKTEKEFKAYVSLFMRHLCEPGADGSETF
ADGVPREGLSRQQVLTRIGVMSLVKKKVQEFEH
INGRWSMPELMPDPSADSKRSSRASSPTKTSPTT
PEASATNSPCTSKPATPAPSEKGEGIRTPLEKE
EAENQEEKPEKNSRIGEKMETEADAPSPAPSLG
ERLEPRKIPLEDEVPGVPGEMEPEPGYRGDREKS
ATESTPGERGEEKPLDGQEHRERPEGETGDLGK
REDVKGDRELRPGPRDEPRSNGRREEKTEKPRF
MFNIADGGFTELHTLWQNEERAAISSGKLNEIWH
RRHDYWLLAGIVLHGYARWQDIQNDAQFAIINE
PFKTEANKGNFLEMKNKFLARRFKLLEQALVIE
EQLRRAAYLNLSQEPAHPAMALHARFAEAECLAE
SHQHLSKESLAGNKPANAVLHKVLNQLEELLSD
MKADVTRLPATLSRIPPIAARLQMSERSILSRL
ASKGTEPHPTPAYPPGPYATPPGYGAAFSAAPVG
ALAAAGANYSQMPAGSFITAATNGPPVLVKKEK
EMVGALVSDGLDRKEPRAGEVICIDD*LDPRPA
LHPGPVPEADPQLKRWGLLPALHLPHPLGHHWAR
NPFAPLCSSSLQEGPFVFLHSHTPFPPSLEDCA
GEKKSGWEMAGRVFQVPSSHTAKYTQLPSKWLW
GGKRWSLPSRFPAESALSHVEVENQPCLAFRNFC
GEESFEERRGTLERDENEPWEGGRDEEGWLHVT
VPYLSPRGGWSSYEGGSQLLFSLRIKVPFTGSV

Frame 2

WLPL*GTRRRRRRRWWCRRRKKRRKKRATRRRR
RRWRRPTRTMRRTTTREYSGAGRATTGAATATA
PPAATSSRRRRRRRHRCPRRRRPRRQIRMTFGC
CRQHWV*RRENEDPRSRRRTSQENPENARSVTVR
RNLVLSEMSTGRSQRVGAVNMEPDRVGNEEGST
EKKRRRRQSGGKRGREMGGKSKWNRSHQQLCF*
PGAWRMWSMCSLRRITTRSPTTKPSASS*GP*LL
RRILRSQCLR**PSLGPNGESSVPTTPSRGQQL
LWRRQRQQQQQL*LSRCQLLSRRPPP*HPPDPP
PFHHPLLLISSPHPSEEPKPKRAKVQAIRGGVRA
PECLMDARSFGERKWHHSK*N*GFWVARGRKEA
RMFFRATKVLNQRLRNQTWTVAVSTVPQAGLMA
LSAPRN*REAGQEGRRRRSWAVLQWPGRRRLMAT
RRITRITVRCASRVGKLFCVTPALVPTTSSALI
LSLTGLQRANGAALTVRRRGSSGRPRRKKKNTK
RRERKKGRRRRRMITWSTAAYARTAGSSCAVTRA
SPPTTFIV*TLPCLTFPMVNGCVPDAHAPC*RV
ECRRSYIGGGGSHL*QCQPLNRQMEIQMSHPPV
LFKADQSESSLSSG*DYPTGTAPGPRSFSWKSSI
WLCIETTSGRMTWMSPHPWTMAPARMMGRATSV
K*KTRTMLRWRRSTIVLASSQSG*PSTASSTTV
WIKRGITTI**NGGTYHMTSPRGRKMK*ISLNTK
NISKATGDTEN*LWGKTLPSPASIRRRRRSYRV
MGLPVLPLMILP*NMRLSHGLSQPLEAPCTCIS
WKG*TGYASPGPRALTPF*LMRWG*ARPYKPSSS
STHSTRRATQKVPSW*VPHSLPSLTGSGSSRCG
HPNSMW*HTRVTRTAGPSFVRMNSPLRTMPSKG
ARKLLR*RGRHR*SSMFS*HRMS*SPLIRQHLVP
SAGPVLW*MRPIDSRTTSPSFSGFSMVTR*IIS
CC*QEPHCRIIWRSSSIS*TSSPQRDLTTWRAS
WRSLLTYPKRTRSRNCMICWGHTCCGDSRQMSLR
TCQPRQSSSFGWS*APCRRNTTNTS*LEILRP*
IHEVVGTRCRCLIS*WILRSAATIHTFFPWLLW
SPPNSPVGLMRVGHLLSRLGSSCCSRRCCES*RS
KDTECSSSRR*PKC*TCLRTS*TMKATSMSASM
VVSRVP*GRRPSIGLMLLGPNNSASSCPPELGA
WASIWPLLTLSSSLILTGTPIMTSRPLAGLIGLA
RPTK**FTGL*LARQWKSESHKWPRER*C*HTW
LCGLGWAPRQAPCPSRSLTTFSNLALKSYSRMK
TRGRTRRRTAV*FIMTMRPSLGCWTGTRMQLRTL
TCRT*MSISAPSRWHSTSCGKKTRLRKLSERSS
SRRRMWTLTTGRSC*GITMSNSRKT*PGI*ARA
SGFASKLTTMMLLRKTKTTSQSTRWVQRRRMKTS
MNVLKGVDSQRGSSGMRKISHCLHCWPESGATL
RCWASTPVSGRLSSML*CAGGCHHRMPSPHSGW
CGT*GARLRRSLRPMCLCSCAICVSLGQTALKPL
PMGSLGRD*VASRC*PALESCLSSKRRCRSLST
SMGVGQCRN*CLTPAPILSAPPEPPLLPKRLPP
LLRLLLPTVPAPLNLLLQLQVRKEKA*GHLLRRR
KLKTRRKSQRRTAELGRRWRQRLMPPAQPHHLG
SGWSQGRFL*RMRCQGCLERWSLNLGTVGTERS
QPQSRRQEKGGRRSRWMDRNTGRGRRGKQGIWAR
EKM*KVTGSFDQGLEMSHGPMGDERKRQRSPGS
CSISPMVASQSFTHCGRMRNGQLFPRGNSMRSG
TEDMTIGFWLGLSSMAMHGGRTSRMMLNLPLSTS
HLKLKPIRGTFWR*KISSWPGGSSSWSRRW*LR
SSCGGRPT*TCRRSRRTPPWPSTPASPRPSAWP
RATSTSPRSRWRGTSRPTPSCTRF*TSWRSC*AT
*RRT*PACQPRCPEYPPSQPAFRCPSAASSAGW
PARARSLTPHRPTRRVPTLHLRGTGRPSAPHP*
GPWPPQAPITARCLQGPSSQPPPTALQCL*RRRR
KWWGHWCQTGWIGRSPEPGR*SV*TTDWIPGLP
FTQAPSPRPTPSSSAGACCQPSTFPTPWAITGL
GTPLPLSAAPLFKKGPLSFSTPTHLSHQALKTVL
VRRSLGGRWLAGSSKYLPPTLPSIHNFPVNGCG
EERGGASPAVSLQNQLCLMWKWRISLAWPLGTF
VGKRALKRGGGL*RGMKMSPGREEGTRRGGCMLP
SPTSPHVEGGAVMREEVNCCSASE*RCRSLAQ

Sequence NM_001005273

ATCTTTGTTTGGGTCTCCCATACTGCGTATAGATGAATGGGTCAGGATATCTGGAACAAAATATGGAGGTGAAGGGTGAGATCGGGAAACAAAGGGTATG
GCCCCCTAGTTCCCAAAGGGAGCAGGGAGATGGGAATAGAATTGAAGGTAGGTTTTAGGCTACTTGGGAGGAGGAATATTTAGGTAATTGTGGAGACTTT
CTCCTGTGTGATGAAGGCGGCAGACACTGTGATCCTGTGGGCAAGAAGTAAAAATGACCAGCTGAGGATTTCTTTTCCTCCAGGACTGTGTTGGGGTGAC
AGGATGCCTGATAAGGATGACATTCGGCTGCTGCCGTCAGCATTGGGTGTGAAGAAGAGAAAACGAGGACCCAAGAAGCAGAAGGAGAACAAGCCAGGAA
AACCCCGAAAACGCAAGAAGCGTGACAGTGAGGAGGAATTTGGTTCTGAGCGAGATGAGTACCGGGAGAAGTCAGAGAGTGGGGGCAGTGAATATGGAAC
CGGACCGGGTCGGAAACGAAGAAGGAAGCACCGAGAAAAAAAGGAGAAGAAGACAAAGCGGCGGAAAAAGGGGGAGGGAGATGGGGGGCAAAAGCAAGTG
GAACAGAAGTCATCAGCAACTCTGCTTCTGACCTGGGGCCTGGAGGATGTGGAGCATGTGTTCTCTGAGGAGGATTACCACACGCTCACCAACTACAAAG
CCTTCAGCCAGTTCATGAGGCCCCTAATTGCTAAGAAGAATCCTAAGATCCCAATGTCTAAGATGATGACCATCCTTGGGGCCAAATGGAGAGAGTTCAG
TGCCAACAACCCCTTCAAGGGGTCAGCAGCTGCTGTGGCGGCGGCAGCGGCAGCAGCAGCAGCAGCTGTAGCTGAGCAGGTGTCAGCTGCTGTCTCGTCG
GCCACCCCCATAGCACCCTCCGGACCCCCCGCCCTTCCACCACCCCCTGCTGCTGATATCCAGCCCCCACCCATCCGAAGAGCCAAAACCAAAGAGGGCA
AAGGTCCAGGCCATAAGAGGCGGAGTAAGAGCCCCCGAGTGCCTGATGGACGCAAGAAGCTTCGGGGAAAGAAAATGGCACCACTCAAAATAAAACTAGG
GCTTCTGGGTGGCAAGAGGAAGAAAGGAGGCTCGTATGTTTTTCAGAGCGACGAAGGTCCTGAACCAGAGGCTGAGGAATCAGACCTGGACAGTGGCAGT
GTCCACAGTGCCTCAGGCCGGCCTGATGGCCCTGTCCGCACCAAGAAACTAAAGAGAGGCCGGCCAGGAAGGAAGAAGAAGAAGGTCCTGGGCTGTCCTG
CAGTGGCCGGGGAGGAGGAGGTTGATGGCTACGAGACGGATCACCAGGATTACTGTGAGGTGTGCCAGCAGGGTGGGGAAATTATTCTGTGTGACACCTG
CCCTCGTGCCTACCACCTCGTCTGCCTTGATCCTGAGCTTGACCGGGCTCCAGAGGGCAAATGGAGCTGCCCTCACTGTGAGAAGGAGGGGGTCCAGTGG
GAGGCCAAGGAGGAAGAAGAAGAATACGAAGAGGAGGGAGAGGAAGAAGGGGAGAAGGAGGAGGAGGATGATCACATGGAGTACTGCCGCGTATGCAAGG
ACGGCGGGGAGCTCCTGTGCTGTGACGCGTGCATCTCCTCCTACCACATTCATTGTCTAAACCCTCCCCTGCCTGACATTCCCAATGGTGAATGGCTGTG
TCCCCGATGCACATGCCCCGTGCTGAAGGGTCGAGTGCAGAAGATCCTACATTGGCGGTGGGGGGAGCCACCTGTAGCAGTGCCAGCCCCTCAACAGGCA
GATGGAAATCCAGATGTCCCACCCCCCCGTCCTCTTCAAGGCAGATCAGAGCGAGAGTTCTTTGTCAAGTGGGTAGGACTATCCTACTGGCACTGCTCCT
GGGCCAAGGAGCTTCAGCTGGAAATCTTCCATTTGGTTATGTATCGAAACTACCAGCGGAAGAATGACATGGATGAGCCCCCACCCCTGGACTATGGCTC
CGGCGAGGATGATGGGAAGAGCGACAAGCGTAAAGTGAAAGACCCGCACTATGCTGAGATGGAGGAGAAGTACTATCGTTTTGGCATCAAGCCAGAGTGG
ATGACCGTCCACCGCATCATCAACCACAGTGTGGATAAAAAGGGGAATTACCACTATCTAGTAAAATGGAGGGACTTACCATATGACCAGTCCACGTGGG
AGGAAGATGAAATGAATATCCCTGAATACGAAGAACATAAGCAAAGCTACTGGAGACACCGAGAACTAATTATGGGGGAAGACCCTGCCCAGCCCCGCAA
GTATAAGAAGAAGAAGAAGGAGCTACAGGGTGATGGGCCTCCCAGTTCTCCCACTAATGATCCTACCGTGAAATATGAGACTCAGCCACGGTTTATCACA
GCCACTGGAGGCACCCTGCACATGTATCAGTTGGAAGGGCTGAACTGGCTACGCTTCTCCTGGGCCCAGGGCACTGACACCATTCTAGCTGATGAGATGG
GGCTAGGCAAGACCATACAAACCATCGTCTTCCTCTACTCACTCTACAAGGAGGGCCACACAAAAGGTCCCTTCCTGGTGAGTGCCCCACTCTCTACCAT
CATTAACTGGGAGCGGGAGTTCCAGATGTGGGCACCCAAATTCTATGTGGTGACATACACGGGTGACAAGGACAGCCGGGCCATCATTCGTGAGAATGAA
TTCTCCTTTGAGGACAATGCCATCAAAGGGGGCAAGAAAGCTTTTAAGATGAAGAGGGAGGCACAGGTGAAGTTCCATGTTCTCCTGACATCGTATGAGC
TGATCACCATTGATCAGGCAGCACTTGGTTCCATCCGCTGGGCCTGTCTTGTGGTAGATGAGGCCCATCGACTCAAGAACAACCAGTCCAAGTTTTTCAG
GGTTCTCAATGGTTACAAGATAGATCATAAGTTGCTGCTGACAGGAACCCCATTGCAGAATAATCTGGAGGAGCTCTTCCATCTCCTGAACTTCCTCACC
CCAGAGAGATTTAACAACTTGGAGGGCTTCCTGGAGGAGTTTGCTGACATATCCAAAGAGGACCAGATCAAGAAACTGCATGATTTGCTGGGGCCACACA
TGCTGCGGAGACTCAAGGCAGATGTCTTTAAGAACATGCCAGCCAAGACAGAGCTCATCGTTCGGGTGGAGCTAAGCCCCATGCAGAAGAAATACTACAA
ATACATCCTGACTCGAAATTTTGAGGCCTTGAATTCACGAGGTGGTGGGAACCAGGTGTCGCTGCTTAATATCATGATGGATCTTAAGAAGTGCTGCAAC
CATCCATACCTTTTTCCCGTGGCTGCTATGGAGTCCCCCAAACTCCCCAGTGGGGCTTATGAGGGTGGGGCACTTATTAAGTCGTCTGGGAAGCTCATGC
TGCTCCAGAAGATGCTGCGAAAGCTGAAGGAGCAAGGACACCGAGTGCTCATCTTCTCGCAGATGACCAAAATGTTAGACTTGCTTGAGGACTTCTTAGA
CTATGAAGGCTACAAGTATGAGCGCATCGATGGTGGTATCACGGGTGCCCTGAGGCAGGAGGCCATCGATCGGTTTAATGCTCCTGGGGCCCAACAATTC
TGCTTCCTCCTGTCCACCCGAGCTGGGGGCCTGGGCATCAATCTGGCCACTGCTGACACTGTCATCATCTTTGATTCTGACTGGAACCCCCATAATGACA
TCCAGGCCTTTAGCCGGGCTCATCGGATTGGCCAGGCCAACAAAGTGATGATTTACCGGTTTGTGACTCGCGCGTCAGTGGAAGAGCGAATCACACAAGT
GGCCAAGAGAAAGATGATGCTGACACACCTGGTTGTGCGGCCTGGGCTGGGCTCCAAGGCAGGCTCCATGTCCAAGCAGGAGCTTGACGACATTCTCAAA
TTTGGCACTGAAGAGCTATTCAAGGATGAAAACGAGGGGGAGAACAAGGAGGAGGACAGCAGTGTGATTCATTATGACAATGAGGCCATCGCTCGGCTGT
TGGACCGGAACCAGGATGCAACTGAGGACACTGACGTGCAGAACATGAATGAGTATCTCAGCTCCTTCAAGGTGGCACAGTACGTCGTGCGGGAAGAAGA
CAAGATTGAGGAAATTGAGCGAGAGATCATCAAGCAGGAGGAGAATGTGGACCCTGACTACTGGGAGAAGCTGCTGAGGCATCACTATGAGCAACAGCAG
GAAGACCTAGCCCGGAATCTAGGCAAGGGCAAGCGGGTTCGCAAGCAAGTTAACTACAATGATGCTGCTCAGGAAGACCAAGACAACCAGTCAGAGTACT
CGGTGGGTTCAGAGGAGGAGGATGAAGACTTCGATGAACGTCCTGAAGGGCGTAGACAGTCAAAGAGGCAGCTCCGGAATGAGAAAGATAAGCCACTGCC
TCCACTGCTGGCCCGAGTCGGGGGCAACATTGAGGTGCTGGGCTTCAACACCCGTCAGCGGAAGGCTTTCCTCAATGCTGTGATGCGCTGGGGGATGCCA
CCACAGGATGCCTTCACCACACAGTGGCTGGTGCGGGACCTGAGGGGCAAGACTGAGAAGGAGTTTAAGGCCTATGTGTCTTTGTTCATGCGCCATCTGT
GTGAGCCTGGGGCAGACGGCTCTGAAACCTTTGCCGATGGGGTCCCTCGGGAGGGACTGAGTCGCCAGCAGGTGTTGACCCGCATTGGAGTCATGTCTCT
CGTCAAAAAGAAGGTGCAGGAGTTTGAGCACATCAATGGGCGTTGGTCAATGCCGGAACTGATGCCTGACCCCAGCGCCGATTCTAAGCGCTCCTCCAGA
GCCTCCTCTCCTACCAAAACGTCTCCCACCACTCCTGAGGCTTCTGCTACCAACAGTCCCTGCACCTCTAAACCTGCTACTCCAGCTCCAAGTGAGAAAG
GAGAAGGCATAAGGACACCTCTTGAGAAGGAGGAAGCTGAAAACCAGGAGGAAAAGCCAGAGAAGAACAGCAGAATTGGGGAGAAGATGGAGACAGAGGC
TGATGCCCCCAGCCCAGCCCCATCACTTGGGGAGCGGCTGGAGCCAAGGAAGATTCCTCTAGAGGATGAGGTGCCAGGGGTGCCTGGAGAGATGGAGCCT
GAACCTGGGTACCGTGGGGACAGAGAGAAGTCAGCCACAGAGTCGACGCCAGGAGAAAGGGGGGAGGAGAAGCCGTTGGATGGACAGGAACACAGGGAGA
GGCCGGAGGGGGAAACAGGGGATTTGGGCAAGAGAGAAGATGTAAAAGGTGACCGGGAGCTTCGACCAGGGCCTCGAGATGAGCCACGGTCCAATGGGCG
ACGAGAGGAAAAGACAGAGAAGCCCCGGTTCATGTTCAATATCGCCGATGGTGGCTTCACAGAGCTTCACACACTGTGGCAGAATGAGGAACGGGCAGCT
ATTTCCTCGGGGAAACTCAATGAGATCTGGCACAGAAGACATGACTATTGGCTTCTGGCTGGGATTGTCCTCCATGGCTATGCACGGTGGCAGGACATCC
AGAATGATGCTCAATTTGCCATTATCAACGAGCCATTTAAAACTGAAGCCAATAAGGGGAACTTTCTGGAGATGAAAAATAAGTTCCTGGCCCGGAGGTT
CAAGCTCCTGGAGCAGGCGCTGGTGATTGAGGAGCAGCTGCGGCGGGCGGCCTACCTGAACCTGTCGCAGGAGCCGGCGCACCCCGCCATGGCCCTCCAC
GCCCGCTTCGCCGAGGCCGAGTGCCTGGCCGAGAGCCACCAGCACCTCTCCAAGGAGTCGCTGGCGGGGAACAAGCCGGCCAACGCCGTCCTGCACAAGG
TTCTGAACCAGCTGGAGGAGTTGCTGAGCGACATGAAGGCGGACGTGACCCGCCTGCCAGCCACGCTGTCCCGAATACCCCCCATCGCAGCCCGCCTTCA
GATGTCCGAGCGCAGCATCCTCAGCCGGCTGGCCAGCAAGGGCACGGAGCCTCACCCCACACCGGCCTACCCGCCGGGTCCCTACGCTACACCTCCGGGG
TACGGGGCGGCCTTCAGCGCCGCACCCGTAGGGGCCCTGGCCGCCGCAGGCGCCAATTACAGCCAGATGCCTGCAGGGTCCTTCATCACAGCCGCCACCA
ACGGCCCTCCAGTGCTTGTGAAGAAGGAGAAGGAAATGGTGGGGGCATTGGTGTCAGACGGGCTGGATCGGAAGGAGCCCCGAGCCGGGGAGGTGATCTG
TATAGACGACTGACTGGATCCCAGGCCTGCCCTTCACCCAGGCCCCGTCCCCGAGGCCGACCCCCAGCTCAAGCGCTGGGGCCTGCTGCCAGCCCTCCAC
CTTCCCCACCCCTTGGGCCATCACTGGGCTAGGAACCCCTTTGCCCCTCTCTGCAGCTCCTCTCTTCAAGAAGGGCCCTTTGTCTTTCTCCACTCCCACA
CACCTTTCCCACCAAGCCTTGAAGACTGTGCTGGTGAGAAGAAGTCTGGGTGGGAGATGGCTGGCAGGGTCTTCCAAGTACCTTCCTCCCACACTGCCAA
GTATACACAACTTCCCAGTAAATGGTTGTGGGGAGGAAAGAGGTGGAGCCTCCCCAGCCGTTTCCCTGCAGAATCAGCTCTGTCTCATGTGGAAGTGGAG
AATCAGCCTTGCCTGGCCTTTAGGAACTTTTGTGGGGAAGAGAGCTTTGAAGAGAGGAGGGGGACTTTAGAGAGGGATGAAAATGAGCCCTGGGAGGGAG
GAAGGGACGAGGAGGGGTGGCTGCATGTTACCGTCCCCTACCTCTCCCCACGTGGAGGGTGGAGCAGTTATGAGGGAGGAAGTCAACTGCTGTTCAGCCT
CAGAATAAAGGTGCCGTTCACTGGCTCAGTT
  • refseq_CHD3.F1 (forward primer)
  • refseq_CHD3.R1 (reverse primer)
  • Single exon skipping

Frame 0

IFVWVSHTAYR*MGQDIWNKIWR*RVRSGNKGY
GPLVPKGSREMGIELKVGFRLLGRRNI*VIVETF
SCVMKAADTVILWARSKNDQLRISFPPGLCWGD
RMPDKDDIRLLPSALGVKKRKRGPKKQKENKPG
KPRKRKKRDSEEEFGSERDEYREKSESGGSEYGT
GPGRKRRRKHREKKEKKTKRRKKGEGDGGQKQV
EQKSSATLLLTWGLEDVEHVFSEEDYHTLTNYK
AFSQFMRPLIAKKNPKIPMSKMMTILGAKWREFS
ANNPFKGSAAAVAAAAAAAAAAVAEQVSAAVSS
ATPIAPSGPPALPPPPAADIQPPPIRRAKTKEG
KGPGHKRRSKSPRVPDGRKKLRGKKMAPLKIKLG
LLGGKRKKGGSYVFQSDEGPEPEAEESDLDSGS
VHSASGRPDGPVRTKKLKRGRPGRKKKKVLGCP
AVAGEEEVDGYETDHQDYCEVCQQGGEIILCDTC
PRAYHLVCLDPELDRAPEGKWSCPHCEKEGVQW
EAKEEEEEYEEEGEEEGEKEEEDDHMEYCRVCK
DGGELLCCDACISSYHIHCLNPPLPDIPNGEWLC
PRCTCPVLKGRVQKILHWRWGEPPVAVPAPQQA
DGNPDVPPPRPLQGRSEREFFVKWVGLSYWHCS
WAKELQLEIFHLVMYRNYQRKNDMDEPPPLDYGS
GEDDGKSDKRKVKDPHYAEMEEKYYRFGIKPEW
MTVHRIINHSVDKKGNYHYLVKWRDLPYDQSTW
EEDEMNIPEYEEHKQSYWRHRELIMGEDPAQPRK
YKKKKKELQGDGPPSSPTNDPTVKYETQPRFIT
ATGGTLHMYQLEGLNWLRFSWAQGTDTILADEM
GLGKTIQTIVFLYSLYKEGHTKGPFLVSAPLSTI
INWEREFQMWAPKFYVVTYTGDKDSRAIIRENE
FSFEDNAIKGGKKAFKMKREAQVKFHVLLTSYE
LITIDQAALGSIRWACLVVDEAHRLKNNQSKFFR
VLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLT
PERFNNLEGFLEEFADISKEDQIKKLHDLLGPH
MLRRLKADVFKNMPAKTELIVRVELSPMQKKYYK
YILTRNFEALNSRGGGNQVSLLNIMMDLKKCCN
HPYLFPVAAMESPKLPSGAYEGGALIKSSGKLM
LLQKMLRKLKEQGHRVLIFSQMTKMLDLLEDFLD
YEGYKYERIDGGITGALRQEAIDRFNAPGAQQF
CFLLSTRAGGLGINLATADTVIIFDSDWNPHND
IQAFSRAHRIGQANKVMIYRFVTRASVEERITQV
AKRKMMLTHLVVRPGLGSKAGSMSKQELDDILK
FGTEELFKDENEGENKEEDSSVIHYDNEAIARL
LDRNQDATEDTDVQNMNEYLSSFKVAQYVVREED
KIEEIEREIIKQEENVDPDYWEKLLRHHYEQQQ
EDLARNLGKGKRVRKQVNYNDAAQEDQDNQSEY
SVGSEEEDEDFDERPEGRRQSKRQLRNEKDKPLP
PLLARVGGNIEVLGFNTRQRKAFLNAVMRWGMP
PQDAFTTQWLVRDLRGKTEKEFKAYVSLFMRHL
CEPGADGSETFADGVPREGLSRQQVLTRIGVMSL
VKKKVQEFEHINGRWSMPELMPDPSADSKRSSR
ASSPTKTSPTTPEASATNSPCTSKPATPAPSEK
GEGIRTPLEKEEAENQEEKPEKNSRIGEKMETEA
DAPSPAPSLGERLEPRKIPLEDEVPGVPGEMEP
EPGYRGDREKSATESTPGERGEEKPLDGQEHRE
RPEGETGDLGKREDVKGDRELRPGPRDEPRSNGR
REEKTEKPRFMFNIADGGFTELHTLWQNEERAA
ISSGKLNEIWHRRHDYWLLAGIVLHGYARWQDI
QNDAQFAIINEPFKTEANKGNFLEMKNKFLARRF
KLLEQALVIEEQLRRAAYLNLSQEPAHPAMALH
ARFAEAECLAESHQHLSKESLAGNKPANAVLHK
VLNQLEELLSDMKADVTRLPATLSRIPPIAARLQ
MSERSILSRLASKGTEPHPTPAYPPGPYATPPG
YGAAFSAAPVGALAAAGANYSQMPAGSFITAAT
NGPPVLVKKEKEMVGALVSDGLDRKEPRAGEVIC
IDD*LDPRPALHPGPVPEADPQLKRWGLLPALH
LPHPLGHHWARNPFAPLCSSSLQEGPFVFLHSH
TPFPPSLEDCAGEKKSGWEMAGRVFQVPSSHTAK
YTQLPSKWLWGGKRWSLPSRFPAESALSHVEVE
NQPCLAFRNFCGEESFEERRGTLERDENEPWEG
GRDEEGWLHVTVPYLSPRGGWSSYEGGSQLLFSL
RIKVPFTGSV

Frame 1

SLFGSPILRIDEWVRISGTKYGGEG*DRETKGM
AP*FPKGAGRWE*N*R*VLGYLGGGIFR*LWRL
SPV**RRQTL*SCGQEVKMTS*GFLFLQDCVGVT
GCLIRMTFGCCRQHWV*RRENEDPRSRRRTSQE
NPENARSVTVRRNLVLSEMSTGRSQRVGAVNME
PDRVGNEEGSTEKKRRRRQSGGKRGREMGGKSKW
NRSHQQLCF*PGAWRMWSMCSLRRITTRSPTTK
PSASS*GP*LLRRILRSQCLR**PSLGPNGESS
VPTTPSRGQQLLWRRQRQQQQQL*LSRCQLLSRR
PPP*HPPDPPPFHHPLLLISSPHPSEEPKPKRA
KVQAIRGGVRAPECLMDARSFGERKWHHSK*N*
GFWVARGRKEARMFFRATKVLNQRLRNQTWTVAV
STVPQAGLMALSAPRN*REAGQEGRRRRSWAVL
QWPGRRRLMATRRITRITVRCASRVGKLFCVTP
ALVPTTSSALILSLTGLQRANGAALTVRRRGSSG
RPRRKKKNTKRRERKKGRRRRRMITWSTAAYAR
TAGSSCAVTRASPPTTFIV*TLPCLTFPMVNGC
VPDAHAPC*RVECRRSYIGGGGSHL*QCQPLNRQ
MEIQMSHPPVLFKADQSESSLSSG*DYPTGTAP
GPRSFSWKSSIWLCIETTSGRMTWMSPHPWTMA
PARMMGRATSVK*KTRTMLRWRRSTIVLASSQSG
*PSTASSTTVWIKRGITTI**NGGTYHMTSPRG
RKMK*ISLNTKNISKATGDTEN*LWGKTLPSPA
SIRRRRRSYRVMGLPVLPLMILP*NMRLSHGLSQ
PLEAPCTCISWKG*TGYASPGPRALTPF*LMRW
G*ARPYKPSSSSTHSTRRATQKVPSW*VPHSLP
SLTGSGSSRCGHPNSMW*HTRVTRTAGPSFVRMN
SPLRTMPSKGARKLLR*RGRHR*SSMFS*HRMS
*SPLIRQHLVPSAGPVLW*MRPIDSRTTSPSFS
GFSMVTR*IISCC*QEPHCRIIWRSSSIS*TSSP
QRDLTTWRASWRSLLTYPKRTRSRNCMICWGHT
CCGDSRQMSLRTCQPRQSSSFGWS*APCRRNTT
NTS*LEILRP*IHEVVGTRCRCLIS*WILRSAAT
IHTFFPWLLWSPPNSPVGLMRVGHLLSRLGSSC
CSRRCCES*RSKDTECSSSRR*PKC*TCLRTS*
TMKATSMSASMVVSRVP*GRRPSIGLMLLGPNNS
ASSCPPELGAWASIWPLLTLSSSLILTGTPIMT
SRPLAGLIGLARPTK**FTGL*LARQWKSESHK
WPRER*C*HTWLCGLGWAPRQAPCPSRSLTTFSN
LALKSYSRMKTRGRTRRRTAV*FIMTMRPSLGC
WTGTRMQLRTLTCRT*MSISAPSRWHSTSCGKK
TRLRKLSERSSSRRRMWTLTTGRSC*GITMSNSR
KT*PGI*ARASGFASKLTTMMLLRKTKTTSQST
RWVQRRRMKTSMNVLKGVDSQRGSSGMRKISHC
LHCWPESGATLRCWASTPVSGRLSSML*CAGGCH
HRMPSPHSGWCGT*GARLRRSLRPMCLCSCAIC
VSLGQTALKPLPMGSLGRD*VASRC*PALESCL
SSKRRCRSLSTSMGVGQCRN*CLTPAPILSAPPE
PPLLPKRLPPLLRLLLPTVPAPLNLLLQLQVRK
EKA*GHLLRRRKLKTRRKSQRRTAELGRRWRQR
LMPPAQPHHLGSGWSQGRFL*RMRCQGCLERWSL
NLGTVGTERSQPQSRRQEKGGRRSRWMDRNTGR
GRRGKQGIWAREKM*KVTGSFDQGLEMSHGPMG
DERKRQRSPGSCSISPMVASQSFTHCGRMRNGQL
FPRGNSMRSGTEDMTIGFWLGLSSMAMHGGRTS
RMMLNLPLSTSHLKLKPIRGTFWR*KISSWPGG
SSSWSRRW*LRSSCGGRPT*TCRRSRRTPPWPST
PASPRPSAWPRATSTSPRSRWRGTSRPTPSCTR
F*TSWRSC*AT*RRT*PACQPRCPEYPPSQPAF
RCPSAASSAGWPARARSLTPHRPTRRVPTLHLRG
TGRPSAPHP*GPWPPQAPITARCLQGPSSQPPP
TALQCL*RRRRKWWGHWCQTGWIGRSPEPGR*S
V*TTDWIPGLPFTQAPSPRPTPSSSAGACCQPST
FPTPWAITGLGTPLPLSAAPLFKKGPLSFSTPT
HLSHQALKTVLVRRSLGGRWLAGSSKYLPPTLP
SIHNFPVNGCGEERGGASPAVSLQNQLCLMWKWR
ISLAWPLGTFVGKRALKRGGGL*RGMKMSPGRE
EGTRRGGCMLPSPTSPHVEGGAVMREEVNCCSA
SE*RCRSLAQ

Frame 2

LCLGLPYCV*MNGSGYLEQNMEVKGEIGKQRVW
PPSSQREQGDGNRIEGRF*ATWEEEYLGNCGDF
LLCDEGGRHCDPVGKK*K*PAEDFFSSRTVLG*
QDA**G*HSAAAVSIGCEEEKTRTQEAEGEQARK
TPKTQEA*Q*GGIWF*AR*VPGEVREWGQ*IWN
RTGSETKKEAPRKKGEEDKAAEKGGGRWGAKAS
GTEVISNSASDLGPGGCGACVL*GGLPHAHQLQS
LQPVHEAPNC*EES*DPNV*DDDHPWGQMERVQ
CQQPLQGVSSCCGGGSGSSSSSCS*AGVSCCLV
GHPHSTLRTPRPSTTPCC*YPAPTHPKSQNQRGQ
RSRP*EAE*EPPSA*WTQEASGKENGTTQNKTR
ASGWQEEERRLVCFSERRRS*TRG*GIRPGQWQ
CPQCLRPA*WPCPHQETKERPARKEEEEGPGLSC
SGRGGGG*WLRDGSPGLL*GVPAGWGNYSV*HL
PSCLPPRLP*S*A*PGSRGQMELPSL*EGGGPV
GGQGGRRRIRRGGRGRRGEGGGG*SHGVLPRMQG
RRGAPVL*RVHLLLPHSLSKPSPA*HSQW*MAV
SPMHMPRAEGSSAEDPTLAVGGATCSSASPSTG
RWKSRCPTPPSSSRQIRARVLCQVGRTILLALLL
GQGASAGNLPFGYVSKLPAEE*HG*APTPGLWL
RRG*WEERQA*SERPALC*DGGEVLSFWHQARV
DDRPPHHQPQCG*KGELPLSSKMEGLTI*PVHVG
GR*NEYP*IRRT*AKLLETPRTNYGGRPCPAPQ
V*EEEEGATG*WASQFSH**SYREI*DSATVYH
SHWRHPAHVSVGRAELATLLLGPGH*HHSS**DG
ARQDHTNHRLPLLTLQGGPHKRSLPGECPTLYH
H*LGAGVPDVGTQILCGDIHG*QGQPGHHS*E*
ILL*GQCHQRGQESF*DEEGGTGEVPCSPDIV*A
DHH*SGSTWFHPLGLSCGR*GPSTQEQPVQVFQ
GSQWLQDRS*VAADRNPIAE*SGGALPSPELPH
PREI*QLGGLPGGVC*HIQRGPDQETA*FAGATH
AAETQGRCL*EHASQDRAHRSGGAKPHAEEILQ
IHPDSKF*GLEFTRWWEPGVAA*YHDGS*EVLQ
PSIPFSRGCYGVPQTPQWGL*GWGTY*VVWEAHA
APEDAAKAEGARTPSAHLLADDQNVRLA*GLLR
L*RLQV*AHRWWYHGCPEAGGHRSV*CSWGPTI
LLPPVHPSWGPGHQSGHC*HCHHL*F*LEPP**H
PGL*PGSSDWPGQQSDDLPVCDSRVSGRANHTS
GQEKDDADTPGCAAWAGLQGRLHVQAGA*RHSQ
IWH*RAIQG*KRGGEQGGGQQCDSL*Q*GHRSAV
GPEPGCN*GH*RAEHE*VSQLLQGGTVRRAGRR
QD*GN*ARDHQAGGECGP*LLGEAAEASL*ATA
GRPSPESRQGQAGSQAS*LQ*CCSGRPRQPVRVL
GGFRGGG*RLR*TS*RA*TVKEAAPE*ER*ATA
STAGPSRGQH*GAGLQHPSAEGFPQCCDALGDA
TTGCLHHTVAGAGPEGQD*EGV*GLCVFVHAPSV
*AWGRRL*NLCRWGPSGGTESPAGVDPHWSHVS
RQKEGAGV*AHQWALVNAGTDA*PQRRF*ALLQ
SLLSYQNVSHHS*GFCYQQSLHL*TCYSSSK*ER
RRHKDTS*EGGS*KPGGKAREEQQNWGEDGDRG
*CPQPSPITWGAAGAKEDSSRG*GARGAWRDGA
*TWVPWGQREVSHRVDARRKGGGEAVGWTGTQGE
AGGGNRGFGQERRCKR*PGASTRASR*ATVQWA
TRGKDREAPVHVQYRRWWLHRASHTVAE*GTGS
YFLGETQ*DLAQKT*LLASGWDCPPWLCTVAGHP
E*CSICHYQRAI*N*SQ*GELSGDEK*VPGPEV
QAPGAGAGD*GAAAAGGLPEPVAGAGAPRHGPP
RPLRRGRVPGREPPAPLQGVAGGEQAGQRRPAQG
SEPAGGVAERHEGGRDPPASHAVPNTPHRSPPS
DVRAQHPQPAGQQGHGASPHTGLPAGSLRYTSG
VRGGLQRRTRRGPGRRRRQLQPDACRVLHHSRHQ
RPSSACEEGEGNGGGIGVRRAGSEGAPSRGGDL
YRRLTGSQACPSPRPRPRGRPPAQALGPAASPP
PSPPLGPSLG*EPLCPSLQLLSSRRALCLSPLPH
TFPTKP*RLCW*EEVWVGDGWQGLPSTFLPHCQ
VYTTSQ*MVVGRKEVEPPQPFPCRISSVSCGSG
ESALPGL*ELLWGREL*REEGDFREG*K*ALGGR
KGRGGVAACYRPLPLPTWRVEQL*GRKSTAVQP
QNKGAVHWLS

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