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Sequences

Sequence NM_001002838

CTCAGCTCCGGGCCGAGCGCGAGCTTGGGCTCGTACCCCGCTCCCCTCTCTCCGCCCGCTCTTTACCTACCGGCCGTAGCTGGCCCGGTGGGCTCGCGGG GAGACGCTCGCGCGCGCAAGCGCACACGACGCGGAGCGGAGCTCGAGACATCGAGGAGAGGAGTAAGAAGCATCGGAGGAGGCGATCGAGGAGGAGGCGG TGTGTGTGTATGTGTCTATTCTACGGTGTGGCTCGTCGTGGGGCGAGAGGAGGCTCGAGAGAGGGCGAGGGAGAAGCGAAAAGAGTAAGAGAGTCTTCCT TTGCGAGAGCCTCTAATCTGGTTGCTATGGAAATACATGACCACGCAAAAGGAAGTCCATTCTGATAATTCTGATACCTGAGATGTAACTGGACTGAAGA GTAGAAACAGGAAAAATTTTAGTGCCAACTTTAATTACAATGGCCACTGATTCAGGGGATCCAGCCAGCACAGAAGATTCTGAGAAACCTGATGGAATTT CATTTGAAAACAGAGTTCCCCAGGTCGCTGCAACTTTGACAGTAGAAGCTAGACTAAAGGAGAAAAACAGTACCTTCTCTGCTTCTGGGGAAACTGTAGA AAGGAAGAGATTTTTCCGAAAGAGTGTTGAAATGACGGAAGATGACAAAGTTGCCGAATCATCCCCCAAAGATGAGAGAATTAAGGCTGCAATGAATATT CCAAGAGTAGATAAGCTTCCTTCAAATGTGTTGAGAGGTGGACAAGAAGTTAAATATGAACAGTGTTCAAAGTCAACCTCAGAAATCTCAAAAGATTGTT TCAAGGAGAAAAATGAAAAGGAAATGGAAGAAGAAGCAGAAATGAAGGCTGTAGCTACTTCTCCTAGTGGCAGATTCCTGAAATTTGACATAGAACTAGG AAGAGGAGCATTTAAAACAGTATATAAAGGACTGGACACTGAAACATGGGTTGAGGTTGCTTGGTGTGAGCTGCAGGACCGAAAGTTAACCAAAGCTGAG CAGCAAAGATTCAAGGAAGAAGCAGAGATGTTGAAGGGTCTCCAGCACCCCAATATAGTTCGATTTTATGATTCCTGGGAATCTATATTAAAAGGAAAGA AATGTATTGTATTAGTGACTGAACTAATGACATCTGGGACCTTAAAGACGTACTTAAAACGATTTAAAGTCATGAAACCAAAGGTCTTAAGGAGCTGGTG CAGGCAAATTTTAAAGGGGTTGCAGTTCTTGCACACTAGGACTCCTCCTATTATTCACCGGGATCTGAAGTGTGACAATATTTTCATCACGGGACCCACT GGATCTGTGAAGATTGGTGATCTAGGATTAGCCACCTTAATGCGTACCTCATTTGCTAAGAGTGTCATTGGAACTCCTGAGTTTATGGCTCCAGAGATGT ATGAAGAACACTATGATGAATCCGTAGATGTTTATGCTTTTGGAATGTGTATGCTGGAAATGGCCACATCGGAGTATCCTTATTCTGAGTGTCAGAATGC AGCTCAAATATACCGGAAAGTAACTAGTGGCATAAAACCAGCCAGCTTCAATAAAGTCACTGATCCTGAAGTCAAAGAAATCATTGAAGGATGTATTCGT CAAAACAAATCTGAAAGGTTGTCTATCAGGGACCTATTAAACCATGCATTTTTTGCTGAGGATACAGGACTGAGGGTGGAGTTAGCAGAAGAAGATGATT GCTCAAATTCATCCCTTGCTTTAAGACTCTGGGTTGAAGACCCTAAAAAATTGAAAGGCAAACACAAAGACAATGAAGCTATTGAATTTAGTTTCAACTT AGAAACAGATACACCTGAGGAAGTAGCATATGAAATGGTCAAGTCTGGGTTCTTCCATGAAAGTGATTCCAAAGCTGTTGCTAAATCCATTAGAGACCGG GTGACGCCAATAAAGAAGACAAGAGAGAAGAAGCCTGCTGGCTGTTTGGAAGAACGCAGGGATTCTCAGTGCAAGTCTATGGGGAATGTATTCCCTCAGC CCCAGAATACAACTTTACCCCTTGCTCCCGCTCAGCAAACTGGGGCTGAATGTGAAGAAACTGAAGTTGATCAACATGTTAGACAACAGCTTCTACAAAG AAAACCACAGCAGCACTGCTCCTCTGTTACAGGTGACAATTTGTCTGAGGCAGGAGCTGCATCAGTTATACATTCAGATACTTCAAGTCAGCCCAGTGTA GCCTATTCCTCAAATCAAACGATGGGCTCTCAAATGGTTTCTAATATCCCGCAGGCTGAAGTAAATGTTCCAGGGCAAATTTATTCATCTCAGCAACTAG TAGGACATTACCAGCAAGTTTCAGGGTTACAGAAGCATTCAAAGCTGACTCAGCCGCAGATTTTGCCTTTGGTTCAAGGTCAGTCCACTGTTTTACCTGT ACATGTCCTTGGACCGACAGTTGTTTCACAACCCCAGGTTTCCCCATTAACTGTTCAGAAGGTCCCACAGATAAAGCCTGTATCCCAACCAGTTGGAGCT GAACAACAAGCAGCTCTTCTAAAACCAGATTTAGTTCGAAGCTTGAATCAAGATGTGGCAACTACGAAGGAAAACGTCAGTAGCCCTGATAACCCAAGTG GAAATGGCAAACAGGATCGGATCAAACAGAGAAGAGCTTCCTGTCCCCGACCAGAGAAGGGGACTAAATTTCAGCTTACCGTCCTTCAGGTATCAACCTC TGGAGATAACATGGTAGAGTGTCAGCTGGAGACACACAACAACAAGATGGTCACCTTCAAGTTTGATGTTGATGGTGATGCGCCAGAGGATATTGCAGAC TATATGGTTGAAGATAACTTTGTGCTGGAAAGTGAGAAAGAAAAATTTGTAGAAGAATTGAGAGCTATTGTAGGTCAAGCCCAGGAGATCCTTCATGTCC ACTTTGCCACAGAAAGAGCCACTGGAGTTGATTCTATTACTGTGGACTCCAACAGTAGCCAGACAGGGTCATCTGAACAAGTACAGATAAATTCTACATC TACTCAAACCAGCAATGAATCTGCTCCTCAGTCATCCCCAGTTGGTCGGTGGCGATTCTGTATCAATCAGACGATAAGAAACCGTGAGACTCAGTCTCCT CCTTCTCTTCAGCATTCCATGTCTGCGGTTCCTGGCCGACATCCACTTCCTAGTCCAAAAAACACAAGTAATAAGGAAATATCACGGGACACATTGCTCA CTATAGAAAATAATCCATGCCACCGTGCACTTTTCACCTCCAAATCAGAACACAAGGATGTGGTTGATGGTAAGATTTCTGAATGTGCTAGTGTAGAAAC CAAGCAGCCAGCTATACTTTATCAAGTGGAAGATAACAGGCAGATAATGGCACCAGTTACTAATAGTTCCAGTTACTCTACTACTTCAGTTCGTGCAGTT CCAGCTGAATGTGAGGGACTCACCAAACAAGCAAGCATATTCATACCTGTGTATCCATGTCACCAAACTGCCAGTCAGGCTGATGCACTTATGTCCCATC CTGGCGAATCAACTCAGACTTCTGGTAACTCTCTTACAACTCTGGCATTTGATCAAAAGCCTCAAACCTTATCAGTACAGCAGCCAGCTATGGATGCAGA GTTTATTTCTCAAGAAGGAGAAACTACAGTGAACACTGAAGCAAGTTCTCCTAAGACAGTCATTCCCACTCAGACCCCTGGCCTTGAACCAACTACCCTT CAACCCACTACTGTCCTGGAATCAGATGGAGAAAGACCTCCAAAACTGGAGTTTGCAGACAACCGAATTAAAACTCTGGATGAAAAATTAAGAAACTTGC TCTATCAGGAGCACAGCATCTCTAGCATCTATCCCGAGAGTCAGAAGGATACCCAAAGCATAGACTCTCCATTTTCTTCCTCTGCTGAAGATACCCTCTC CTGTCCAGTGACAGAAGTCATAGCCATCAGTCACTGTGGAATTAAAGATAGCCCTGTACAATCCCCTAATTTCCAACAGACAGGCTCTAAGCTTCTGTCC AATGTGGCTGCAAGTCAGCCTGCTAATATATCAGTGTTCAAAAGGGACCTGAATGTGATAACTTCTGTACCCAGCGAATTGTGTTTACATGAGATGTCCT CAGATGCTTCACTTCCAGGGGATCCAGAGGCCTATCCTGCTGCTGTGTCAAGCGGTGGAGCCATTCATCTGCAGACAGGAGTGGAAACAGAAGAGATGAG ATCAGCAATTGCTCCTGATCCCATTCCTCTGACACGGGAGTCCACAGCTGATACTAGGGCTTTGAATAGATGTAAAGCGATGAGTGGATCATTTCAGCGG GGTCGGTTCCAGGTGATTACAATTCCTCAGCAGCAGTCAGCAAAAATGACATCTTTTGGAATAGAACACATATCAGTGTTCAGTGAGACAAACCATTCTA GTGAAGAAGCCTTTATTAAAACAGCAAAGTCTCAGTTGGTAGAAATAGAACCTGCCACACAAAATCCAAAAACTTCGTTTTCTTATGAGAAGTTACAAGC TCTTCAGGAAACCTGTAAAGAAAATAAAGGAGTTCCCAAACAAGGTGACAACTTCTTATCTTTCAGCGCAGCTTGTGAGACTGATGTATCTTCAGTGACC CCAGAAAAGGAATTTGAAGAAACTTCAGCCACAGGAAGTAGCATGCAGTCTGGATCTGAACTGTTGCTTAAAGAGAGAGAGATATTGACTGCTGGGAAAC AGCCTAGCTCTGATAGTGAATTTTCAGCCAGTCTTGCTGGCAGTGGAAAGTCAGTGGCAAAGACTGGTCCAGAGAGTAATCAGTGCTTACCACACCACGA AGAACAAGCTTATGCTCAAACACAGAGTTCACTCTTCTATTCGCCATCTTCCCCAATGAGCAGTGATGATGAATCAGAAATAGAGGATGAGGACTTGAAG GTGGAGCTTCAAAGATTACGAGAAAAACACATTCAGGAGGTGGTAAATCTTCAAACCCAGCAGAATAAGGAGCTGCAGGAGCTCTATGAACGCCTTCGGT CAATTAAAGATAGCAAAACCCAATCTACTGAGATTCCTTTGCCACCTGCATCACCACGTCGACCAAGATCTTTCAAAAGCAAACTTCGAAGCCGCCCCCA GTCCTTGACACATGTGGACAATGGCATAGTTGCTACAGATCCACTGTGTGTGGAGAGTAATGCAGCATCATGCCAACAGTCTCCAGCCAGTAAAAAAGGG ATGTTCACAGATGACTTACACAAGCTGGTGGATGACTGGACAAAGGAAGCAGTAGGAAATTCTCTTATTAAGCCAAGTTTAAACCAACTTAAACAAAGTC AACACAAACTAGAGACAGAAAACTGGAATAAAGTATCTGAAAATACTCCGTCTACTATGGGCTACACATCAACATGGATTTCTTCTCTGTCCCAAATCCG TGGAGCTGTCCCAACTTCCTTGCCACAAGGACTCTCACTCCCTTCATTTCCTGGGCCATTATCATCATATGGAATGCCTCACGTTTGTCAGTATAATGCT GTGGCGGGGGCGGGGTATCCAGTACAGTGGGTAGGAATTTCAGGAACAACACAACAATCTGTAGTAATTCCCGCCCAATCTGGGGGACCATTCCAGCCAG GGATGAATATGCAGGCATTTCCAACTTCATCAGTGCAGAATCCTGCCACAATCCCTCCTGGTCCTAAATGAATCAGAGTAGATGGTGATAAAAAGGGAGG TTTTTTCAGAATTATTTTCAGGACACCCAAGATATTAAAGTTTCTTCCTCTTGGGTTCTGTCATATTTTCCCTCATTTGAGTTTACTTTAGACTATATAT TTTTTGTTCCAGTGTGGTATTTGATACAGCTCATCATTCTGTAGAAATGTGCAGTTTGCAGATAGAACACTGCACACAGAAATGTTTTTTCACTTCAAAT TCTATCCTCTTTGATACTTGATTTTTTAAAAATACTGTTCAGAATGCTTTAATAAGCTCAGCTTGAGCATTACCATTTCCAGGACACTTTCCATGAATTG TTGAGAAGCTCCCCATCCCCCGCCTTTTTTTTTTTTTTTTTTAACTGCTGCTATCTGCAGCTGGATACTCTTCTTTAAAAATGTTTAAAAATTATTTAGA TTGATTCTCCCCAAATGTGGATGAACTGAGACCCTCCATCAGCCAGAGTCTTATGGGATCTTCACTTCACATGTTTGTCTTAGGTTTACCTTTCACAGAA GGCAGGGTAACTTGCTGCAGGAAACGTTTTGGTGTATAAAATTAGAATCACTTTTTTTTTTTTTTTTGAGATGGAGTCTCTCTCTGTCACCCAGGTTGGA GTGCAGTGGTGTGATCTTGGCTCACTGCTGCAACCTCCCCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCC AGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGGATGGGGTTTCACTATGTTGGCCAGACTGGTCTCAAACTCCTAACCTTGTGATCCGCCCTC CTTAGCCCCCCCAAAAAATTACAATAATTTTGTCAACCAATACAGAACATGAGCCCTTTTTAAATGTGATTTCCCGTCATCACAGCAGTAGGATGAAGCC TTGTTTTGGGTGAGACAGAGGGAAAGGGAAAAAACAGAATTGTAACAGTTCCTTGATTCTGCAGATACTGCTGCTGTTTTACGATTTCAGTAATAATTCA AAGCAGCTGTCTCCTTGTTTCTCACATGCATACTACATTGGTTTTGAGCATCTGAGAGGCATTGGTTTGTCTTGCATTCTTTTGCAAGGCATATATTGCA GCTGATATGAATCTCGTTTGGGGGGAATCCTTGTATTCCTAACAAGGGGGATTAAAGCTACACCTCAATCCATTCTTCTGAAGTGAAATTTACTTGACAC AGTAGGTTTCGAGACTTACATATGAAACACTGGCTTTACAGGGTTCTCAGAGATGTGGGGTATACACTGTCCTGCAGTGAGATAGTAGACCCTAGAAGGA TACTATTTAAGTTGTCCTTAGCTCTTTTTAATTACAATTTTTAGTTGTTAGAATTTCTTTTTAGTATCTATAGTATCTTAGATGATTTTAGATCTTAAAT GAGTTTGGCAGCCTCTTTAGAATCTGAGAGAGATCACTGTCAAGTTGCACTTTACTGGGTTTTATCCAGTTTTAGGAGGAGGGGAGGCAATGTCAAAATG TACACCTTTGGTTTTTAAGAAGGTTAACTATAATAATGTTAAAGGCTAGTCACAGGGTTACCTAATGCTCAGTCTGTGAAACCTAAATAGAATTCTTAAA ATGTTATTTACCAACTAAGTATTCATGTTCAAATTACTTACCTTCCACTCTGAAGACTTTAAGGTCATTTCTAATACACATTTACCTAATTAGGAGTTCT GTCTACTAGTAAACATTCCAAATTGCTACCCAACATTACTGTTAACAGATTTTCCTCCGTATTCTTCTAAAAATTATACCCCATGGGCTTGCCAGGTAAT GACGAAAACTTAATGGGTGTACTTTTTTTTTTTTTTGCACAGTCTACTTTGTGACATTAAGTACCTCTTTTCC

refseq_WNK3.F3 (forward primer)
refseq_WNK3.R3 (reverse primer)
Single exon skipping

Frame 0

LSSGPSASLGSYPAPLSPPALYLPAVAGPVGSR GDARARKRTRRGAELETSRRGVRSIGGGDRGGGG VCVCVYSTVWLVVGREEARERAREKRKE*ESLP LREPLIWLLWKYMTTQKEVHSDNSDT*DVTGLK SRNRKNFSANFNYNGH*FRGSSQHRRF*ET*WNF I*KQSSPGRCNFDSRS*TKGEKQYLLCFWGNCR KEEIFPKEC*NDGR*QSCRIIPQR*EN*GCNEY SKSR*ASFKCVERWTRS*I*TVFKVNLRNLKRLF QGEK*KGNGRRSRNEGCSYFS*WQIPEI*HRTR KRSI*NSI*RTGH*NMG*GCLV*AAGPKVNQS* AAKIQGRSRDVEGSPAPQYSSIL*FLGIYIKRKE MYCISD*TNDIWDLKDVLKTI*SHETKGLKELV QANFKGVAVLAH*DSSYYSPGSEV*QYFHHGTH WICEDW*SRISHLNAYLIC*ECHWNS*VYGSRDV *RTL**IRRCLCFWNVYAGNGHIGVSLF*VSEC SSNIPESN*WHKTSQLQ*SH*S*SQRNH*RMYS SKQI*KVVYQGPIKPCIFC*GYRTEGGVSRRR*L LKFIPCFKTLG*RP*KIERQTQRQ*SY*I*FQL RNRYT*GSSI*NGQVWVLP*K*FQSCC*IH*RP GDANKEDKREEACWLFGRTQGFSVQVYGECIPSA PEYNFTPCSRSANWG*M*RN*S*STC*TTASTK KTTAALLLCYR*QFV*GRSCISYTFRYFKSAQC SLFLKSNDGLSNGF*YPAG*SKCSRANLFISATS RTLPASFRVTEAFKADSAADFAFGSRSVHCFTC TCPWTDSCFTTPGFPINCSEGPTDKACIPTSWS *TTSSSSKTRFSSKLESRCGNYEGKRQ*P**PKW KWQTGSDQTEKSFLSPTREGD*ISAYRPSGINL WR*HGRVSAGDTQQQDGHLQV*C*W*CARGYCR LYG*R*LCAGK*ERKICRRIESYCRSSPGDPSCP LCHRKSHWS*FYYCGLQQ*PDRVI*TSTDKFYI YSNQQ*ICSSVIPSWSVAILYQSDDKKP*DSVS SFSSAFHVCGSWPTSTS*SKKHK**GNITGHIAH YRK*SMPPCTFHLQIRTQGCG*W*DF*MC*CRN QAASYTLSSGR*QADNGTSY**FQLLYYFSSCS SS*M*GTHQTSKHIHTCVSMSPNCQSG*CTYVPS WRINSDFW*LSYNSGI*SKASNLISTAASYGCR VYFSRRRNYSEH*SKFS*DSHSHSDPWP*TNYP STHYCPGIRWRKTSKTGVCRQPN*NSG*KIKKLA LSGAQHL*HLSRESEGYPKHRLSIFFLC*RYPL LSSDRSHSHQSLWN*R*PCTIP*FPTDRL*ASV QCGCKSAC*YISVQKGPECDNFCTQRIVFT*DVL RCFTSRGSRGLSCCCVKRWSHSSADRSGNRRDE ISNCS*SHSSDTGVHS*Y*GFE*M*SDEWIISA GSVPGDYNSSAAVSKNDIFWNRTHISVQ*DKPF* *RSLY*NSKVSVGRNRTCHTKSKNFVFL*EVTS SSGNL*RK*RSSQTR*QLLIFQRSL*D*CIFSD PRKGI*RNFSHRK*HAVWI*TVA*RERDIDCWET A*L***IFSQSCWQWKVSGKDWSRE*SVLTTPR RTSLCSNTEFTLLFAIFPNEQ***IRNRG*GLE GGASKITRKTHSGGGKSSNPAE*GAAGAL*TPSV N*R*QNPIY*DSFATCITTSTKIFQKQTSKPPP VLDTCGQWHSCYRSTVCGE*CSIMPTVSSQ*KR DVHR*LTQAGG*LDKGSSRKFSY*AKFKPT*TKS TQTRDRKLE*SI*KYSVYYGLHINMDFFSVPNP WSCPNFLATRTLTPFISWAIIIIWNASRLSV*C CGGGGVSSTVGRNFRNNTTICSNSRPIWGTIPAR DEYAGISNFISAESCHNPSWS*MNQSRW**KGR FFQNYFQDTQDIKVSSSWVLSYFPSFEFTLDYI FFVPVWYLIQLIIL*KCAVCR*NTAHRNVFSLQI LSSLILDFLKILFRML**AQLEHYHFQDTFHEL LRSSPSPAFFFFFFNCCYLQLDTLL*KCLKII* IDSPQMWMN*DPPSARVLWDLHFTCLS*VYLSQK AG*LAAGNVLVYKIRITFFFFFEMESLSVTQVG VQWCDLGSLLQPPPPGFKRFSCLSLLSSWDYRR QPPCLANFCIFSRGWGFTMLARLVSNS*PCDPPS LAPPKNYNNFVNQYRT*ALFKCDFPSSQQ*DEA LFWVRQREREKTEL*QFLDSADTAAVLRFQ**F KAAVSLFLTCILHWF*ASERHWFVLHSFARHILQ LI*ISFGGNPCIPNKGD*SYTSIHSSEVKFT*H SRFRDLHMKHWLYRVLRDVGYTLSCSEIVDPRR ILFKLSLALFNYNF*LLEFLFSIYSILDDFRS*M SLAASLESERDHCQVALYWVLSSFRRRGGNVKM YTFGF*EG*L**C*RLVTGLPNAQSVKPK*NS* NVIYQLSIHVQITYLPL*RL*GHF*YTFT*LGVL STSKHSKLLPNITVNRFSSVFF*KLYPMGLPGN DENLMGVLFFFFAQSTL*H*VPLF

Frame 1

SAPGRARAWARTPLPSLRPLFTYRP*LARWARG ETLARASAHDAERSSRHRGEE*EASEEAIEEEA VCVYVSILRCGSSWGERRLERGRGRSEKSKRVFL CESL*SGCYGNT*PRKRKSILIILIPEM*LD*R VETGKILVPTLITMATDSGDPASTEDSEKPDGI SFENRVPQVAATLTVEARLKEKNSTFSASGETVE RKRFFRKSVEMTEDDKVAESSPKDERIKAAMNI PRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELG RGAFKTVYKGLDTETWVEVAWCELQDRKLTKAE QQRFKEEAEMLKGLQHPNIVRFYDSWESILKGK KCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWC RQILKGLQFLHTRTPPIIHRDLKCDNIFITGPT GSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEM YEEHYDESVDVYAFGMCMLEMATSEYPYSECQNA AQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIR QNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNL ETDTPEEVAYEMVKSGFFHESDSKAVAKSIRDR VTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQ PQNTTLPLAPAQQTGAECEETEVDQHVRQQLLQR KPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSV AYSSNQTMGSQMVSNIPQAEVNVPGQIYSSQQL VGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPV HVLGPTVVSQPQVSPLTVQKVPQIKPVSQPVGA EQQAALLKPDLVRSLNQDVATTKENVSSPDNPS GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTS GDNMVECQLETHNNKMVTFKFDVDGDAPEDIAD YMVEDNFVLESEKEKFVEELRAIVGQAQEILHV HFATERATGVDSITVDSNSSQTGSSEQVQINSTS TQTSNESAPQSSPVGRWRFCINQTIRNRETQSP PSLQHSMSAVPGRHPLPSPKNTSNKEISRDTLL TIENNPCHRALFTSKSEHKDVVDGKISECASVET KQPAILYQVEDNRQIMAPVTNSSSYSTTSVRAV PAECEGLTKQASIFIPVYPCHQTASQADALMSH PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAE FISQEGETTVNTEASSPKTVIPTQTPGLEPTTL QPTTVLESDGERPPKLEFADNRIKTLDEKLRNL LYQEHSISSIYPESQKDTQSIDSPFSSSAEDTLS CPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLS NVAASQPANISVFKRDLNVITSVPSELCLHEMS SDASLPGDPEAYPAAVSSGGAIHLQTGVETEEMR SAIAPDPIPLTRESTADTRALNRCKAMSGSFQR GRFQVITIPQQQSAKMTSFGIEHISVFSETNHS SEEAFIKTAKSQLVEIEPATQNPKTSFSYEKLQA LQETCKENKGVPKQGDNFLSFSAACETDVSSVT PEKEFEETSATGSSMQSGSELLLKEREILTAGK QPSSDSEFSASLAGSGKSVAKTGPESNQCLPHHE EQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLK VELQRLREKHIQEVVNLQTQQNKELQELYERLR SIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQ SLTHVDNGIVATDPLCVESNAASCQQSPASKKG MFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQS QHKLETENWNKVSENTPSTMGYTSTWISSLSQIR GAVPTSLPQGLSLPSFPGPLSSYGMPHVCQYNA VAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQP GMNMQAFPTSSVQNPATIPPGPK*IRVDGDKKGG FFRIIFRTPKILKFLPLGFCHIFPHLSLL*TIY FLFQCGI*YSSSFCRNVQFADRTLHTEMFFHFK FYPL*YLIF*KYCSECFNKLSLSITISRTLSMNC *EAPHPPPFFFFFLTAAICSWILFFKNV*KLFR LILPKCG*TETLHQPESYGIFTSHVCLRFTFHR RQGNLLQETFWCIKLESLFFFFLRWSLSLSPRLE CSGVILAHCCNLPLLGSSDSPASAS*VAGTTGA SHHAWLIFVFLVEDGVSLCWPDWSQTPNLVIRP P*PPQKITIILSTNTEHEPFLNVISRHHSSRMKP CFG*DRGKGKKQNCNSSLILQILLLFYDFSNNS KQLSPCFSHAYYIGFEHLRGIGLSCILLQGIYC S*YESRLGGILVFLTRGIKATPQSILLK*NLLDT VGFETYI*NTGFTGFSEMWGIHCPAVR**TLEG YYLSCP*LFLITIFSC*NFFLVSIVS*MILDLK *VWQPL*NLREITVKLHFTGFYPVLGGGEAMSKC TPLVFKKVNYNNVKG*SQGYLMLSL*NLNRILK MLFTN*VFMFKLLTFHSEDFKVISNTHLPN*EF CLLVNIPNCYPTLLLTDFPPYSSKNYTPWACQVM TKT*WVYFFFFLHSLLCDIKYLFS

Frame 2

QLRAERELGLVPRSPLSARSLPTGRSWPGGLAG RRSRAQAHTTRSGARDIEERSKKHRRRRSRRRR CVCMCLFYGVARRGARGGSREGEGEAKRVRESS FARASNLVAMEIHDHAKGSPF**F*YLRCNWTEE *KQEKF*CQL*LQWPLIQGIQPAQKILRNLMEF HLKTEFPRSLQL*Q*KLD*RRKTVPSLLLGKL* KGRDFSERVLK*RKMTKLPNHPPKMRELRLQ*IF QE*ISFLQMC*EVDKKLNMNSVQSQPQKSQKIV SRRKMKRKWKKKQK*RL*LLLLVADS*NLT*N* EEEHLKQYIKDWTLKHGLRLLGVSCRTES*PKLS SKDSRKKQRC*RVSSTPI*FDFMIPGNLY*KER NVLY**LN**HLGP*RRT*NDLKS*NQRS*GAG AGKF*RGCSSCTLGLLLLFTGI*SVTIFSSRDPL DL*RLVI*D*PP*CVPHLLRVSLELLSLWLQRC MKNTMMNP*MFMLLECVCWKWPHRSILILSVRM QLKYTGK*LVA*NQPASIKSLILKSKKSLKDVFV KTNLKGCLSGTY*TMHFLLRIQD*GWS*QKKMI AQIHPLL*DSGLKTLKN*KANTKTMKLLNLVST *KQIHLRK*HMKWSSLGSSMKVIPKLLLNPLETG *RQ*RRQERRSLLAVWKNAGILSASLWGMYSLS PRIQLYPLLPLSKLGLNVKKLKLINMLDNSFYK ENHSSTAPLLQVTICLRQELHQLYIQILQVSPV* PIPQIKRWALKWFLISRRLK*MFQGKFIHLSN* *DITSKFQGYRSIQS*LSRRFCLWFKVSPLFYL YMSLDRQLFHNPRFPH*LFRRSHR*SLYPNQLEL NNKQLF*NQI*FEA*IKMWQLRRKTSVALITQV EMANRIGSNREELPVPDQRRGLNFSLPSFRYQP LEITW*SVSWRHTTTRWSPSSLMLMVMRQRILQT IWLKITLCWKVRKKNL*KN*ELL*VKPRRSFMS TLPQKEPLELILLLWTPTVARQGHLNKYR*ILH LLKPAMNLLLSHPQLVGGDSVSIRR*ETVRLSLL LLFSIPCLRFLADIHFLVQKTQVIRKYHGTHCS L*KIIHATVHFSPPNQNTRMWLMVRFLNVLV*K PSSQLYFIKWKITGR*WHQLLIVPVTLLLQFVQF QLNVRDSPNKQAYSYLCIHVTKLPVRLMHLCPI LANQLRLLVTLLQLWHLIKSLKPYQYSSQLWMQ SLFLKKEKLQ*TLKQVLLRQSFPLRPLALNQLPF NPLLSWNQMEKDLQNWSLQTTELKLWMKN*ETC SIRSTASLASIPRVRRIPKA*TLHFLPLLKIPS PVQ*QKS*PSVTVELKIALYNPLISNRQALSFCP MWLQVSLLIYQCSKGT*M**LLYPANCVYMRCP QMLHFQGIQRPILLLCQAVEPFICRQEWKQKR* DQQLLLIPFL*HGSPQLILGL*IDVKR*VDHFSG VGSR*LQFLSSSQQK*HLLE*NTYQCSVRQTIL VKKPLLKQQSLSW*K*NLPHKIQKLRFLMRSYK LFRKPVKKIKEFPNKVTTSYLSAQLVRLMYLQ*P QKRNLKKLQPQEVACSLDLNCCLKRERY*LLGN SLALIVNFQPVLLAVESQWQRLVQRVISAYHTT KNKLMLKHRVHSSIRHLPQ*AVMMNQK*RMRT*R WSFKDYEKNTFRRW*IFKPSRIRSCRSSMNAFG QLKIAKPNLLRFLCHLHHHVDQDLSKANFEAAP SP*HMWTMA*LLQIHCVWRVMQHHANSLQPVKKG CSQMTYTSWWMTGQRKQ*EILLLSQV*TNLNKV NTN*RQKTGIKYLKILRLLWATHQHGFLLCPKS VELSQLPCHKDSHSLHFLGHYHHMECLTFVSIML WRGRGIQYSG*EFQEQHNNL**FPPNLGDHSSQ G*ICRHFQLHQCRILPQSLLVLNESE*MVIKRE VFSELFSGHPRY*SFFLLGSVIFSLI*VYFRLYI FCSSVVFDTAHHSVEMCSLQIEHCTQKCFFTSN SILFDT*FFKNTVQNALISSA*ALPFPGHFP*I VEKLPIPRLFFFFF*LLLSAAGYSSLKMFKNYLD *FSPNVDELRPSISQSLMGSSLHMFVLGLPFTE GRVTCCRKRFGV*N*NHFFFFF*DGVSLCHPGW SAVV*SWLTAATSPSWVQAILLPQPPE*LGLQAP ATMPG*FLYF**RMGFHYVGQTGLKLLTL*SAL LSPPKKLQ*FCQPIQNMSPF*M*FPVITAVG*S LVLGETEGKGKNRIVTVP*FCRYCCCFTISVIIQ SSCLLVSHMHTTLVLSI*EALVCLAFFCKAYIA ADMNLVWGESLYS*QGGLKLHLNPFF*SEIYLT Q*VSRLTYETLALQGSQRCGVYTVLQ*DSRP*KD TI*VVLSSF*LQFLVVRISF*YL*YLR*F*ILN EFGSLFRI*ERSLSSCTLLGFIQF*EEGRQCQN VHLWFLRRLTIIMLKASHRVT*CSVCET*IEFLK CYLPTKYSCSNYLPSTLKTLRSFLIHIYLIRSS VY**TFQIATQHYC*QIFLRILLKIIPHGLAR* *RKLNGCTFFFFCTVYFVTLSTSF

Sequence NM_020922

CTCAGCTCCGGGCCGAGCGCGAGCTTGGGCTCGTACCCCGCTCCCCTCTCTCCGCCCGCTCTTTACCTACCGGCCGTAGCTGGCCCGGTGGGCTCGCGGG GAGACGCTCGCGCGCGCAAGCGCACACGACGCGGAGCGGAGCTCGAGACATCGAGGAGAGGAGTAAGAAGCATCGGAGGAGGCGATCGAGGAGGAGGCGG TGTGTGTGTATGTGTCTATTCTACGGTGTGGCTCGTCGTGGGGCGAGAGGAGGCTCGAGAGAGGGCGAGGGAGAAGCGAAAAGAGTAAGAGAGTCTTCCT TTGCGAGAGCCTCTAATCTGGTTGCTATGGAAATACATGACCACGCAAAAGGAAGTCCATTCTGATAATTCTGATACCTGAGATGTAACTGGACTGAAGA GTAGAAACAGGAAAAATTTTAGTGCCAACTTTAATTACAATGGCCACTGATTCAGGGGATCCAGCCAGCACAGAAGATTCTGAGAAACCTGATGGAATTT CATTTGAAAACAGAGTTCCCCAGGTCGCTGCAACTTTGACAGTAGAAGCTAGACTAAAGGAGAAAAACAGTACCTTCTCTGCTTCTGGGGAAACTGTAGA AAGGAAGAGATTTTTCCGAAAGAGTGTTGAAATGACGGAAGATGACAAAGTTGCCGAATCATCCCCCAAAGATGAGAGAATTAAGGCTGCAATGAATATT CCAAGAGTAGATAAGCTTCCTTCAAATGTGTTGAGAGGTGGACAAGAAGTTAAATATGAACAGTGTTCAAAGTCAACCTCAGAAATCTCAAAAGATTGTT TCAAGGAGAAAAATGAAAAGGAAATGGAAGAAGAAGCAGAAATGAAGGCTGTAGCTACTTCTCCTAGTGGCAGATTCCTGAAATTTGACATAGAACTAGG AAGAGGAGCATTTAAAACAGTATATAAAGGACTGGACACTGAAACATGGGTTGAGGTTGCTTGGTGTGAGCTGCAGGACCGAAAGTTAACCAAAGCTGAG CAGCAAAGATTCAAGGAAGAAGCAGAGATGTTGAAGGGTCTCCAGCACCCCAATATAGTTCGATTTTATGATTCCTGGGAATCTATATTAAAAGGAAAGA AATGTATTGTATTAGTGACTGAACTAATGACATCTGGGACCTTAAAGACGTACTTAAAACGATTTAAAGTCATGAAACCAAAGGTCTTAAGGAGCTGGTG CAGGCAAATTTTAAAGGGGTTGCAGTTCTTGCACACTAGGACTCCTCCTATTATTCACCGGGATCTGAAGTGTGACAATATTTTCATCACGGGACCCACT GGATCTGTGAAGATTGGTGATCTAGGATTAGCCACCTTAATGCGTACCTCATTTGCTAAGAGTGTCATTGGAACTCCTGAGTTTATGGCTCCAGAGATGT ATGAAGAACACTATGATGAATCCGTAGATGTTTATGCTTTTGGAATGTGTATGCTGGAAATGGCCACATCGGAGTATCCTTATTCTGAGTGTCAGAATGC AGCTCAAATATACCGGAAAGTAACTAGTGGCATAAAACCAGCCAGCTTCAATAAAGTCACTGATCCTGAAGTCAAAGAAATCATTGAAGGATGTATTCGT CAAAACAAATCTGAAAGGTTGTCTATCAGGGACCTATTAAACCATGCATTTTTTGCTGAGGATACAGGACTGAGGGTGGAGTTAGCAGAAGAAGATGATT GCTCAAATTCATCCCTTGCTTTAAGACTCTGGGTTGAAGACCCTAAAAAATTGAAAGGCAAACACAAAGACAATGAAGCTATTGAATTTAGTTTCAACTT AGAAACAGATACACCTGAGGAAGTAGCATATGAAATGGTCAAGTCTGGGTTCTTCCATGAAAGTGATTCCAAAGCTGTTGCTAAATCCATTAGAGACCGG GTGACGCCAATAAAGAAGACAAGAGAGAAGAAGCCTGCTGGCTGTTTGGAAGAACGCAGGGATTCTCAGTGCAAGTCTATGGGGAATGTATTCCCTCAGC CCCAGAATACAACTTTACCCCTTGCTCCCGCTCAGCAAACTGGGGCTGAATGTGAAGAAACTGAAGTTGATCAACATGTTAGACAACAGCTTCTACAAAG AAAACCACAGCAGCACTGCTCCTCTGTTACAGGTGACAATTTGTCTGAGGCAGGAGCTGCATCAGTTATACATTCAGATACTTCAAGTCAGCCCAGTGTA GCCTATTCCTCAAATCAAACGATGGGCTCTCAAATGGTTTCTAATATCCCGCAGGCTGAAGTAAATGTTCCAGGGCAAATTTATTCATCTCAGCAACTAG TAGGACATTACCAGCAAGTTTCAGGGTTACAGAAGCATTCAAAGCTGACTCAGCCGCAGATTTTGCCTTTGGTTCAAGGTCAGTCCACTGTTTTACCTGT ACATGTCCTTGGACCGACAGTTGTTTCACAACCCCAGGTTTCCCCATTAACTGTTCAGAAGGTCCCACAGATAAAGCCTGTATCCCAACCAGTTGGAGCT GAACAACAAGCAGCTCTTCTAAAACCAGATTTAGTTCGAAGCTTGAATCAAGATGTGGCAACTACGAAGGAAAACGTCAGTAGCCCTGATAACCCAAGTG GAAATGGCAAACAGGATCGGATCAAACAGAGAAGAGCTTCCTGTCCCCGACCAGAGAAGGGGACTAAATTTCAGCTTACCGTCCTTCAGGTATCAACCTC TGGAGATAACATGGTAGAGTGTCAGCTGGAGACACACAACAACAAGATGGTCACCTTCAAGTTTGATGTTGATGGTGATGCGCCAGAGGATATTGCAGAC TATATGGTTGAAGATAACTTTGTGCTGGAAAGTGAGAAAGAAAAATTTGTAGAAGAATTGAGAGCTATTGTAGGTCAAGCCCAGGAGATCCTTCATGTCC ACTTTGCCACAGAAAGAGCCACTGGAGTTGATTCTATTACTGTGGACTCCAACAGTAGCCAGACAGGGTCATCTGAACAAGTACAGATAAATTCTACATC TACTCAAACCAGCAATGAATCTGCTCCTCAGTCATCCCCAGTTGGTCGGTGGCGATTCTGTATCAATCAGACGATAAGAAACCGTGAGACTCAGTCTCCT CCTTCTCTTCAGCATTCCATGTCTGCGGTTCCTGGCCGACATCCACTTCCTAGTCCAAAAAACACAAGTAATAAGGAAATATCACGGGACACATTGCTCA CTATAGAAAATAATCCATGCCACCGTGCACTTTTCACCTCCAAATCAGAACACAAGGATGTGGTTGATGGTAAGATTTCTGAATGTGCTAGTGTAGAAAC CAAGCAGCCAGCTATACTTTATCAAGTGGAAGATAACAGGCAGATAATGGCACCAGTTACTAATAGTTCCAGTTACTCTACTACTTCAGTTCGTGCAGTT CCAGCTGAATGTGAGGGACTCACCAAACAAGCAAGCATATTCATACCTGTGTATCCATGTCACCAAACTGCCAGTCAGGCTGATGCACTTATGTCCCATC CTGGCGAATCAACTCAGACTTCTGGTAACTCTCTTACAACTCTGGCATTTGATCAAAAGCCTCAAACCTTATCAGTACAGCAGCCAGCTATGGATGCAGA GTTTATTTCTCAAGAAGGAGAAACTACAGTGAACACTGAAGCAAGTTCTCCTAAGACAGTCATTCCCACTCAGACCCCTGGCCTTGAACCAACTACCCTT CAACCCACTACTGTCCTGGAATCAGATGGAGAAAGACCTCCAAAACTGGAGTTTGCAGACAACCGAATTAAAACTCTGGATGAAAAATTAAGAAACTTGC TCTATCAGGAGCACAGCATCTCTAGCATCTATCCCGAGAGTCAGAAGGATACCCAAAGCATAGACTCTCCATTTTCTTCCTCTGCTGAAGATACCCTCTC CTGTCCAGTGACAGAAGTCATAGCCATCAGTCACTGTGGAATTAAAGATAGCCCTGTACAATCCCCTAATTTCCAACAGACAGGCTCTAAGCTTCTGTCC AATGTGGCTGCAAGTCAGCCTGCTAATATATCAGTGTTCAAAAGGGACCTGAATGTGATAACTTCTGTACCCAGCGAATTGTGTTTACATGAGATGTCCT CAGATGCTTCACTTCCAGGGGATCCAGAGGCCTATCCTGCTGCTGTGTCAAGCGGTGGAGCCATTCATCTGCAGACAGGAGGTGGATATTTTGGCCTAAG CTTTACTTGTCCTAGTCTCAAAAATCCTATTAGCAAGAAATCCTGGACTCGCAAATTAAAAAGCTGGGCATACAGGCTACGGCAGTCAACCAGCTTTTTC AAGAGATCAAAAGTCCGTCAAGTGGAAACAGAAGAGATGAGATCAGCAATTGCTCCTGATCCCATTCCTCTGACACGGGAGTCCACAGCTGATACTAGGG CTTTGAATAGATGTAAAGCGATGAGTGGATCATTTCAGCGGGGTCGGTTCCAGGTGATTACAATTCCTCAGCAGCAGTCAGCAAAAATGACATCTTTTGG AATAGAACACATATCAGTGTTCAGTGAGACAAACCATTCTAGTGAAGAAGCCTTTATTAAAACAGCAAAGTCTCAGTTGGTAGAAATAGAACCTGCCACA CAAAATCCAAAAACTTCGTTTTCTTATGAGAAGTTACAAGCTCTTCAGGAAACCTGTAAAGAAAATAAAGGAGTTCCCAAACAAGGTGACAACTTCTTAT CTTTCAGCGCAGCTTGTGAGACTGATGTATCTTCAGTGACCCCAGAAAAGGAATTTGAAGAAACTTCAGCCACAGGAAGTAGCATGCAGTCTGGATCTGA ACTGTTGCTTAAAGAGAGAGAGATATTGACTGCTGGGAAACAGCCTAGCTCTGATAGTGAATTTTCAGCCAGTCTTGCTGGCAGTGGAAAGTCAGTGGCA AAGACTGGTCCAGAGAGTAATCAGTGCTTACCACACCACGAAGAACAAGCTTATGCTCAAACACAGAGTTCACTCTTCTATTCGCCATCTTCCCCAATGA GCAGTGATGATGAATCAGAAATAGAGGATGAGGACTTGAAGGTGGAGCTTCAAAGATTACGAGAAAAACACATTCAGGAGGTGGTAAATCTTCAAACCCA GCAGAATAAGGAGCTGCAGGAGCTCTATGAACGCCTTCGGTCAATTAAAGATAGCAAAACCCAATCTACTGAGATTCCTTTGCCACCTGCATCACCACGT CGACCAAGATCTTTCAAAAGCAAACTTCGAAGCCGCCCCCAGTCCTTGACACATGTGGACAATGGCATAGTTGCTACAGGGAAAAGCTGCCTTATAAATG AGTTGGAAAATCCACTGTGTGTGGAGAGTAATGCAGCATCATGCCAACAGTCTCCAGCCAGTAAAAAAGGGATGTTCACAGATGACTTACACAAGCTGGT GGATGACTGGACAAAGGAAGCAGTAGGAAATTCTCTTATTAAGCCAAGTTTAAACCAACTTAAACAAAGTCAACACAAACTAGAGACAGAAAACTGGAAT AAAGTATCTGAAAATACTCCGTCTACTATGGGCTACACATCAACATGGATTTCTTCTCTGTCCCAAATCCGTGGAGCTGTCCCAACTTCCTTGCCACAAG GACTCTCACTCCCTTCATTTCCTGGGCCATTATCATCATATGGAATGCCTCACGTTTGTCAGTATAATGCTGTGGCGGGGGCGGGGTATCCAGTACAGTG GGTAGGAATTTCAGGAACAACACAACAATCTGTAGTAATTCCCGCCCAATCTGGGGGACCATTCCAGCCAGGGATGAATATGCAGGCATTTCCAACTTCA TCAGTGCAGAATCCTGCCACAATCCCTCCTGGTCCTAAATGAATCAGAGTAGATGGTGATAAAAAGGGAGGTTTTTTCAGAATTATTTTCAGGACACCCA AGATATTAAAGTTTCTTCCTCTTGGGTTCTGTCATATTTTCCCTCATTTGAGTTTACTTTAGACTATATATTTTTTGTTCCAGTGTGGTATTTGATACAG CTCATCATTCTGTAGAAATGTGCAGTTTGCAGATAGAACACTGCACACAGAAATGTTTTTTCACTTCAAATTCTATCCTCTTTGATACTTGATTTTTTAA AAATACTGTTCAGAATGCTTTAATAAGCTCAGCTTGAGCATTACCATTTCCAGGACACTTTCCATGAATTGTTGAGAAGCTCCCCATCCCCCGCCTTTTT TTTTTTTTTTTTTAACTGCTGCTATCTGCAGCTGGATACTCTTCTTTAAAAATGTTTAAAAATTATTTAGATTGATTCTCCCCAAATGTGGATGAACTGA GACCCTCCATCAGCCAGAGTCTTATGGGATCTTCACTTCACATGTTTGTCTTAGGTTTACCTTTCACAGAAGGCAGGGTAACTTGCTGCAGGAAACGTTT TGGTGTATAAAATTAGAATCACTTTTTTTTTTTTTTTTGAGATGGAGTCTCTCTCTGTCACCCAGGTTGGAGTGCAGTGGTGTGATCTTGGCTCACTGCT GCAACCTCCCCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCCAGCCACCATGCCTGGCTAATTTTTGTATT TTTAGTAGAGGATGGGGTTTCACTATGTTGGCCAGACTGGTCTCAAACTCCTAACCTTGTGATCCGCCCTCCTTAGCCCCCCCAAAAAATTACAATAATT TTGTCAACCAATACAGAACATGAGCCCTTTTTAAATGTGATTTCCCGTCATCACAGCAGTAGGATGAAGCCTTGTTTTGGGTGAGACAGAGGGAAAGGGA AAAAACAGAATTGTAACAGTTCCTTGATTCTGCAGATACTGCTGCTGTTTTACGATTTCAGTAATAATTCAAAGCAGCTGTCTCCTTGTTTCTCACATGC ATACTACATTGGTTTTGAGCATCTGAGAGGCATTGGTTTGTCTTGCATTCTTTTGCAAGGCATATATTGCAGCTGATATGAATCTCGTTTGGGGGGAATC CTTGTATTCCTAACAAGGGGGATTAAAGCTACACCTCAATCCATTCTTCTGAAGTGAAATTTACTTGACACAGTAGGTTTCGAGACTTACATATGAAACA CTGGCTTTACAGGGTTCTCAGAGATGTGGGGTATACACTGTCCTGCAGTGAGATAGTAGACCCTAGAAGGATACTATTTAAGTTGTCCTTAGCTCTTTTT AATTACAATTTTTAGTTGTTAGAATTTCTTTTTAGTATCTATAGTATCTTAGATGATTTTAGATCTTAAATGAGTTTGGCAGCCTCTTTAGAATCTGAGA GAGATCACTGTCAAGTTGCACTTTACTGGGTTTTATCCAGTTTTAGGAGGAGGGGAGGCAATGTCAAAATGTACACCTTTGGTTTTTAAGAAGGTTAACT ATAATAATGTTAAAGGCTAGTCACAGGGTTACCTAATGCTCAGTCTGTGAAACCTAAATAGAATTCTTAAAATGTTATTTACCAACTAAGTATTCATGTT CAAATTACTTACCTTCCACTCTGAAGACTTTAAGGTCATTTCTAATACACATTTACCTAATTAGGAGTTCTGTCTACTAGTAAACATTCCAAATTGCTAC CCAACATTACTGTTAACAGATTTTCCTCCGTATTCTTCTAAAAATTATACCCCATGGGCTTGCCAGGTAATGACGAAAACTTAATGGGTGTACTTTTTTT TTTTTTTGCACAGTCTACTTTGTGACATTAAGTACCTCTTTTCC

refseq_WNK3.F3 (forward primer)
refseq_WNK3.R3 (reverse primer)
Single exon skipping

Frame 0

LSSGPSASLGSYPAPLSPPALYLPAVAGPVGSR GDARARKRTRRGAELETSRRGVRSIGGGDRGGGG VCVCVYSTVWLVVGREEARERAREKRKE*ESLP LREPLIWLLWKYMTTQKEVHSDNSDT*DVTGLK SRNRKNFSANFNYNGH*FRGSSQHRRF*ET*WNF I*KQSSPGRCNFDSRS*TKGEKQYLLCFWGNCR KEEIFPKEC*NDGR*QSCRIIPQR*EN*GCNEY SKSR*ASFKCVERWTRS*I*TVFKVNLRNLKRLF QGEK*KGNGRRSRNEGCSYFS*WQIPEI*HRTR KRSI*NSI*RTGH*NMG*GCLV*AAGPKVNQS* AAKIQGRSRDVEGSPAPQYSSIL*FLGIYIKRKE MYCISD*TNDIWDLKDVLKTI*SHETKGLKELV QANFKGVAVLAH*DSSYYSPGSEV*QYFHHGTH WICEDW*SRISHLNAYLIC*ECHWNS*VYGSRDV *RTL**IRRCLCFWNVYAGNGHIGVSLF*VSEC SSNIPESN*WHKTSQLQ*SH*S*SQRNH*RMYS SKQI*KVVYQGPIKPCIFC*GYRTEGGVSRRR*L LKFIPCFKTLG*RP*KIERQTQRQ*SY*I*FQL RNRYT*GSSI*NGQVWVLP*K*FQSCC*IH*RP GDANKEDKREEACWLFGRTQGFSVQVYGECIPSA PEYNFTPCSRSANWG*M*RN*S*STC*TTASTK KTTAALLLCYR*QFV*GRSCISYTFRYFKSAQC SLFLKSNDGLSNGF*YPAG*SKCSRANLFISATS RTLPASFRVTEAFKADSAADFAFGSRSVHCFTC TCPWTDSCFTTPGFPINCSEGPTDKACIPTSWS *TTSSSSKTRFSSKLESRCGNYEGKRQ*P**PKW KWQTGSDQTEKSFLSPTREGD*ISAYRPSGINL WR*HGRVSAGDTQQQDGHLQV*C*W*CARGYCR LYG*R*LCAGK*ERKICRRIESYCRSSPGDPSCP LCHRKSHWS*FYYCGLQQ*PDRVI*TSTDKFYI YSNQQ*ICSSVIPSWSVAILYQSDDKKP*DSVS SFSSAFHVCGSWPTSTS*SKKHK**GNITGHIAH YRK*SMPPCTFHLQIRTQGCG*W*DF*MC*CRN QAASYTLSSGR*QADNGTSY**FQLLYYFSSCS SS*M*GTHQTSKHIHTCVSMSPNCQSG*CTYVPS WRINSDFW*LSYNSGI*SKASNLISTAASYGCR VYFSRRRNYSEH*SKFS*DSHSHSDPWP*TNYP STHYCPGIRWRKTSKTGVCRQPN*NSG*KIKKLA LSGAQHL*HLSRESEGYPKHRLSIFFLC*RYPL LSSDRSHSHQSLWN*R*PCTIP*FPTDRL*ASV QCGCKSAC*YISVQKGPECDNFCTQRIVFT*DVL RCFTSRGSRGLSCCCVKRWSHSSADRRWIFWPK LYLS*SQKSY*QEILDSQIKKLGIQATAVNQLF QEIKSPSSGNRRDEISNCS*SHSSDTGVHS*Y*G FE*M*SDEWIISAGSVPGDYNSSAAVSKNDIFW NRTHISVQ*DKPF**RSLY*NSKVSVGRNRTCH TKSKNFVFL*EVTSSSGNL*RK*RSSQTR*QLLI FQRSL*D*CIFSDPRKGI*RNFSHRK*HAVWI* TVA*RERDIDCWETA*L***IFSQSCWQWKVSG KDWSRE*SVLTTPRRTSLCSNTEFTLLFAIFPNE Q***IRNRG*GLEGGASKITRKTHSGGGKSSNP AE*GAAGAL*TPSVN*R*QNPIY*DSFATCITT STKIFQKQTSKPPPVLDTCGQWHSCYREKLPYK* VGKSTVCGE*CSIMPTVSSQ*KRDVHR*LTQAG G*LDKGSSRKFSY*AKFKPT*TKSTQTRDRKLE *SI*KYSVYYGLHINMDFFSVPNPWSCPNFLATR TLTPFISWAIIIIWNASRLSV*CCGGGGVSSTV GRNFRNNTTICSNSRPIWGTIPARDEYAGISNF ISAESCHNPSWS*MNQSRW**KGRFFQNYFQDTQ DIKVSSSWVLSYFPSFEFTLDYIFFVPVWYLIQ LIIL*KCAVCR*NTAHRNVFSLQILSSLILDFL KILFRML**AQLEHYHFQDTFHELLRSSPSPAFF FFFFNCCYLQLDTLL*KCLKII*IDSPQMWMN* DPPSARVLWDLHFTCLS*VYLSQKAG*LAAGNV LVYKIRITFFFFFEMESLSVTQVGVQWCDLGSLL QPPPPGFKRFSCLSLLSSWDYRRQPPCLANFCI FSRGWGFTMLARLVSNS*PCDPPSLAPPKNYNN FVNQYRT*ALFKCDFPSSQQ*DEALFWVRQRERE KTEL*QFLDSADTAAVLRFQ**FKAAVSLFLTC ILHWF*ASERHWFVLHSFARHILQLI*ISFGGN PCIPNKGD*SYTSIHSSEVKFT*HSRFRDLHMKH WLYRVLRDVGYTLSCSEIVDPRRILFKLSLALF NYNF*LLEFLFSIYSILDDFRS*MSLAASLESE RDHCQVALYWVLSSFRRRGGNVKMYTFGF*EG*L **C*RLVTGLPNAQSVKPK*NS*NVIYQLSIHV QITYLPL*RL*GHF*YTFT*LGVLSTSKHSKLL PNITVNRFSSVFF*KLYPMGLPGNDENLMGVLFF FFAQSTL*H*VPLF

Frame 1

SAPGRARAWARTPLPSLRPLFTYRP*LARWARG ETLARASAHDAERSSRHRGEE*EASEEAIEEEA VCVYVSILRCGSSWGERRLERGRGRSEKSKRVFL CESL*SGCYGNT*PRKRKSILIILIPEM*LD*R VETGKILVPTLITMATDSGDPASTEDSEKPDGI SFENRVPQVAATLTVEARLKEKNSTFSASGETVE RKRFFRKSVEMTEDDKVAESSPKDERIKAAMNI PRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELG RGAFKTVYKGLDTETWVEVAWCELQDRKLTKAE QQRFKEEAEMLKGLQHPNIVRFYDSWESILKGK KCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWC RQILKGLQFLHTRTPPIIHRDLKCDNIFITGPT GSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEM YEEHYDESVDVYAFGMCMLEMATSEYPYSECQNA AQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIR QNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNL ETDTPEEVAYEMVKSGFFHESDSKAVAKSIRDR VTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQ PQNTTLPLAPAQQTGAECEETEVDQHVRQQLLQR KPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSV AYSSNQTMGSQMVSNIPQAEVNVPGQIYSSQQL VGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPV HVLGPTVVSQPQVSPLTVQKVPQIKPVSQPVGA EQQAALLKPDLVRSLNQDVATTKENVSSPDNPS GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTS GDNMVECQLETHNNKMVTFKFDVDGDAPEDIAD YMVEDNFVLESEKEKFVEELRAIVGQAQEILHV HFATERATGVDSITVDSNSSQTGSSEQVQINSTS TQTSNESAPQSSPVGRWRFCINQTIRNRETQSP PSLQHSMSAVPGRHPLPSPKNTSNKEISRDTLL TIENNPCHRALFTSKSEHKDVVDGKISECASVET KQPAILYQVEDNRQIMAPVTNSSSYSTTSVRAV PAECEGLTKQASIFIPVYPCHQTASQADALMSH PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAE FISQEGETTVNTEASSPKTVIPTQTPGLEPTTL QPTTVLESDGERPPKLEFADNRIKTLDEKLRNL LYQEHSISSIYPESQKDTQSIDSPFSSSAEDTLS CPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLS NVAASQPANISVFKRDLNVITSVPSELCLHEMS SDASLPGDPEAYPAAVSSGGAIHLQTGGGYFGLS FTCPSLKNPISKKSWTRKLKSWAYRLRQSTSFF KRSKVRQVETEEMRSAIAPDPIPLTRESTADTR ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFG IEHISVFSETNHSSEEAFIKTAKSQLVEIEPAT QNPKTSFSYEKLQALQETCKENKGVPKQGDNFL SFSAACETDVSSVTPEKEFEETSATGSSMQSGSE LLLKEREILTAGKQPSSDSEFSASLAGSGKSVA KTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPM SSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQ QNKELQELYERLRSIKDSKTQSTEIPLPPASPR RPRSFKSKLRSRPQSLTHVDNGIVATGKSCLIN ELENPLCVESNAASCQQSPASKKGMFTDDLHKLV DDWTKEAVGNSLIKPSLNQLKQSQHKLETENWN KVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQ GLSLPSFPGPLSSYGMPHVCQYNAVAGAGYPVQW VGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTS SVQNPATIPPGPK*IRVDGDKKGGFFRIIFRTP KILKFLPLGFCHIFPHLSLL*TIYFLFQCGI*YS SSFCRNVQFADRTLHTEMFFHFKFYPL*YLIF* KYCSECFNKLSLSITISRTLSMNC*EAPHPPPF FFFFLTAAICSWILFFKNV*KLFRLILPKCG*TE TLHQPESYGIFTSHVCLRFTFHRRQGNLLQETF WCIKLESLFFFFLRWSLSLSPRLECSGVILAHC CNLPLLGSSDSPASAS*VAGTTGASHHAWLIFVF LVEDGVSLCWPDWSQTPNLVIRPP*PPQKITII LSTNTEHEPFLNVISRHHSSRMKPCFG*DRGKG KKQNCNSSLILQILLLFYDFSNNSKQLSPCFSHA YYIGFEHLRGIGLSCILLQGIYCS*YESRLGGI LVFLTRGIKATPQSILLK*NLLDTVGFETYI*N TGFTGFSEMWGIHCPAVR**TLEGYYLSCP*LFL ITIFSC*NFFLVSIVS*MILDLK*VWQPL*NLR EITVKLHFTGFYPVLGGGEAMSKCTPLVFKKVN YNNVKG*SQGYLMLSL*NLNRILKMLFTN*VFMF KLLTFHSEDFKVISNTHLPN*EFCLLVNIPNCY PTLLLTDFPPYSSKNYTPWACQVMTKT*WVYFF FFLHSLLCDIKYLFS

Frame 2

QLRAERELGLVPRSPLSARSLPTGRSWPGGLAG RRSRAQAHTTRSGARDIEERSKKHRRRRSRRRR CVCMCLFYGVARRGARGGSREGEGEAKRVRESS FARASNLVAMEIHDHAKGSPF**F*YLRCNWTEE *KQEKF*CQL*LQWPLIQGIQPAQKILRNLMEF HLKTEFPRSLQL*Q*KLD*RRKTVPSLLLGKL* KGRDFSERVLK*RKMTKLPNHPPKMRELRLQ*IF QE*ISFLQMC*EVDKKLNMNSVQSQPQKSQKIV SRRKMKRKWKKKQK*RL*LLLLVADS*NLT*N* EEEHLKQYIKDWTLKHGLRLLGVSCRTES*PKLS SKDSRKKQRC*RVSSTPI*FDFMIPGNLY*KER NVLY**LN**HLGP*RRT*NDLKS*NQRS*GAG AGKF*RGCSSCTLGLLLLFTGI*SVTIFSSRDPL DL*RLVI*D*PP*CVPHLLRVSLELLSLWLQRC MKNTMMNP*MFMLLECVCWKWPHRSILILSVRM QLKYTGK*LVA*NQPASIKSLILKSKKSLKDVFV KTNLKGCLSGTY*TMHFLLRIQD*GWS*QKKMI AQIHPLL*DSGLKTLKN*KANTKTMKLLNLVST *KQIHLRK*HMKWSSLGSSMKVIPKLLLNPLETG *RQ*RRQERRSLLAVWKNAGILSASLWGMYSLS PRIQLYPLLPLSKLGLNVKKLKLINMLDNSFYK ENHSSTAPLLQVTICLRQELHQLYIQILQVSPV* PIPQIKRWALKWFLISRRLK*MFQGKFIHLSN* *DITSKFQGYRSIQS*LSRRFCLWFKVSPLFYL YMSLDRQLFHNPRFPH*LFRRSHR*SLYPNQLEL NNKQLF*NQI*FEA*IKMWQLRRKTSVALITQV EMANRIGSNREELPVPDQRRGLNFSLPSFRYQP LEITW*SVSWRHTTTRWSPSSLMLMVMRQRILQT IWLKITLCWKVRKKNL*KN*ELL*VKPRRSFMS TLPQKEPLELILLLWTPTVARQGHLNKYR*ILH LLKPAMNLLLSHPQLVGGDSVSIRR*ETVRLSLL LLFSIPCLRFLADIHFLVQKTQVIRKYHGTHCS L*KIIHATVHFSPPNQNTRMWLMVRFLNVLV*K PSSQLYFIKWKITGR*WHQLLIVPVTLLLQFVQF QLNVRDSPNKQAYSYLCIHVTKLPVRLMHLCPI LANQLRLLVTLLQLWHLIKSLKPYQYSSQLWMQ SLFLKKEKLQ*TLKQVLLRQSFPLRPLALNQLPF NPLLSWNQMEKDLQNWSLQTTELKLWMKN*ETC SIRSTASLASIPRVRRIPKA*TLHFLPLLKIPS PVQ*QKS*PSVTVELKIALYNPLISNRQALSFCP MWLQVSLLIYQCSKGT*M**LLYPANCVYMRCP QMLHFQGIQRPILLLCQAVEPFICRQEVDILA* ALLVLVSKILLARNPGLAN*KAGHTGYGSQPAFS RDQKSVKWKQKR*DQQLLLIPFL*HGSPQLILG L*IDVKR*VDHFSGVGSR*LQFLSSSQQK*HLL E*NTYQCSVRQTILVKKPLLKQQSLSW*K*NLPH KIQKLRFLMRSYKLFRKPVKKIKEFPNKVTTSY LSAQLVRLMYLQ*PQKRNLKKLQPQEVACSLDL NCCLKRERY*LLGNSLALIVNFQPVLLAVESQWQ RLVQRVISAYHTTKNKLMLKHRVHSSIRHLPQ* AVMMNQK*RMRT*RWSFKDYEKNTFRRW*IFKP SRIRSCRSSMNAFGQLKIAKPNLLRFLCHLHHHV DQDLSKANFEAAPSP*HMWTMA*LLQGKAAL*M SWKIHCVWRVMQHHANSLQPVKKGCSQMTYTSW WMTGQRKQ*EILLLSQV*TNLNKVNTN*RQKTGI KYLKILRLLWATHQHGFLLCPKSVELSQLPCHK DSHSLHFLGHYHHMECLTFVSIMLWRGRGIQYS G*EFQEQHNNL**FPPNLGDHSSQG*ICRHFQLH QCRILPQSLLVLNESE*MVIKREVFSELFSGHP RY*SFFLLGSVIFSLI*VYFRLYIFCSSVVFDT AHHSVEMCSLQIEHCTQKCFFTSNSILFDT*FFK NTVQNALISSA*ALPFPGHFP*IVEKLPIPRLF FFFF*LLLSAAGYSSLKMFKNYLD*FSPNVDEL RPSISQSLMGSSLHMFVLGLPFTEGRVTCCRKRF GV*N*NHFFFFF*DGVSLCHPGWSAVV*SWLTA ATSPSWVQAILLPQPPE*LGLQAPATMPG*FLY F**RMGFHYVGQTGLKLLTL*SALLSPPKKLQ*F CQPIQNMSPF*M*FPVITAVG*SLVLGETEGKG KNRIVTVP*FCRYCCCFTISVIIQSSCLLVSHM HTTLVLSI*EALVCLAFFCKAYIAADMNLVWGES LYS*QGGLKLHLNPFF*SEIYLTQ*VSRLTYET LALQGSQRCGVYTVLQ*DSRP*KDTI*VVLSSF *LQFLVVRISF*YL*YLR*F*ILNEFGSLFRI*E RSLSSCTLLGFIQF*EEGRQCQNVHLWFLRRLT IIMLKASHRVT*CSVCET*IEFLKCYLPTKYSC SNYLPSTLKTLRSFLIHIYLIRSSVY**TFQIAT QHYC*QIFLRILLKIIPHGLAR**RKLNGCTFF FFCTVYFVTLSTSF