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Sequences

Sequence NM_014784

AGCGAAATCTCCGTTTCATGGAGGCTGAGGCAAGAGAAAATTTCGGAGCCTGGATGTGGAGGAGCCCAACAGCAGAACTAACTCAGGAAATTGTCTTTCA GAAAAAGGCCGAACGTAGGCTGGGTCTGAGAATCAGGCTGGGGTAGGTGGAGGAACCTGCAAGTTTAAAGGAAAAAGAAAAGGAGAGAATATTTTCAGAG ATTATCTCTGGTTTGTTATCATTACTACCATCTTAAAGGTAAAAAGCATTGCATTTCAGGTGTTCTTTGATTTTTATTTTATTTTTTTTTTTGGTGCAAT TGGCTCATTTAAGAATTTCAAAACATTTAATGTAAAAGCTTTTTTTTTTTTAAGGAAGTCCATAAATTTTGGTTCCCAGGGTTGCACTGGACTTGGAAGG AGTGCTGTTGTGTACATACTATTGTATGGTTTTATTTATTATTTTACTGTACAAATCAGCCGAAAGAATTTTTCCAAGTGCCATTTCGGATTTATTAATC CTTTTTTTTTTCCTTTCCTCAAAGATATTTGCTGTTGTCATATTAAGCATTGGAGACTAGAAAATTACTTTCCCCCTTTGAGCTAGAGGGTCTCTTGCCA ACAGAAGGACAGCTGAGAAAGCTGGATTTAAAGGATGGTTTTATCTGTACTTTGCAGTTAACAGTGATATTTTGAAGGCACATTTTTCTGTGATTCATTT TTTTTTGGCCATAGTGCTAACCTTGAAGAGATTCGTGGCTGGGTTTTTGGTTTCTGAGAAGGTCGTAGTTTTTCCTCTTTTCCTTTTTTTTTCTTTTTTC TTTTCTTTTCTTTTTTTTTAAAGCGGGGGAGGGGAAGAGGGGCTGAGAAAGGAAATCATGTTCACTGGTAGAAGTAGAGTGGAGCATCAGTTACCAGGGT CCTGAGAGCTGGAGGAGAAAGGATTCTATCTTCAAGTTGGGAGGCCCTCCTCTCACCTTGCTCAAAAATTGCAAGCGATTCAATCCTGATCAAGACACCA AAGCTACAGGATTCTGGAACCGTGGAGACACCGAGAAACCATGAGTGTAAGGTTACCCCAGAGTATAGACAGGTTAAGTAGCCTGTCTTCTCTGGGAGAT TCTGCACCAGAGCGCAAGTCCCCTTCCCACCATCGCCAGCCTTCGGATGCCTCTGAGACAACAGGTCTCGTTCAACGCTGTGTCATTATCCAAAAGGACC AGCATGGCTTCGGCTTCACAGTCAGTGGGGATCGCATTGTTCTGGTGCAGTCTGTGCGGCCTGGAGGTGCAGCCATGAAGGCCGGTGTGAAAGAGGGCGA CCGGATCATCAAAGTCAACGGCACCATGGTGACCAATAGCTCACACCTGGAAGTGGTAAAGCTGATCAAATCTGGCGCCTATGTCGCACTCACCCTCCTG GGCTCTTCACCTTCATCCATGGGCATCTCTGGGCTCCAGCAGGACCCATCCCCAGCAGGAGCTCCCCGAATCACGTCAGTGATCCCCTCACCACCACCTC CTCCACCTCTACCACCTCCACAACGCATCACAGGACCCAAACCTCTGCAGGATCCCGAAGTTCAAAAACATGCCACCCAGATCCTCAGGAATATGCTGAG GCAGGAAGAAAAAGAATTACAGGACATACTTCCACTATATGGTGACACCAGCCAGAGACCATCAGAAGGCCGGCTCTCTCTGGATTCCCAGGAGGGGGAC AGTGGCTTGGACTCTGGGACAGAACGCTTTCCTTCCCTCAGTGAGTCATTGATGAATCGGAACTCGGTACTGTCAGACCCTGGGCTAGACAGTCCTCGAA CCTCCCCTGTGATCATGGCCAGGGTGGCCCAGCACCACAGGCGGCAGGGCTCGGATGCAGCAGTCCCCTCAACCGGTGACCAGGGTGTAGATCAAAGCCC AAAGCCTTTAATTATTGGCCCAGAGGAAGACTATGACCCGGGTTATTTCAACAACGAGAGCGACATCATATTCCAGGATCTGGAGAAACTGAAGTCTCGG CCAGCTCACCTGGGGGTTTTTCTACGTTACATCTTCTCTCAGGCGGACCCCAGTCCACTGCTTTTTTACCTGTGTGCAGAAGTTTATCAGCAGGCAAGCC CCAAGGATTCCCGAAGCTTGGGGAAAGACATCTGGAATATTTTCCTGGAGAAAAATGCGCCTCTGAGAGTGAAGATCCCTGAGATGCTACAGGCTGAAAT TGACTCGCGCCTGCGGAACAGCGAAGATGCCCGTGGTGTTCTCTGTGAAGCTCAAGAGGCAGCCATGCCTGAGATCCAAGAGCAGATCCACGACTACAGA ACGAAGCGCACACTGGGGCTGGGCAGCCTGTATGGTGAAAATGACCTGCTGGACCTGGATGGGGACCCTCTCCGAGAGCGCCAAGTGGCTGAGAAGCAGC TGGCTGCCCTTGGAGATATTTTGTCCAAGTATGAGGAAGACAGGAGCGCCCCCATGGACTTCGCCCTCAATACCTACATGAGCCATGCTGGGATCCGTCT TCGAGAGGCACGACCTTCCAACACAGCTGAAAAGGCCCAGTCTGCTCCTGACAAGGACAAGTGGCTACCGTTCTTCCCTAAGACCAAGAAGAGCAGCAAT TCCAAGAAAGAAAAGGATGCCTTGGAGGACAAGAAGCGAAACCCTATCCTCAAATACATTGGGAAGCCCAAAAGCTCTTCTCAAAGCACATTTCATATTC CCTTGTCCCCTGTGGAAGTCAAACCAGGCAATGTGAGGAACATCATTCAGCACTTTGAGAACAACCAGCAGTATGATGCCCCAGAACCTGGGACACAACG ACTCTCGACCGGAAGCTTTCCTGAGGACCTGCTGGAGAGTGACAGTTCACGCTCAGAGATTCGCCTGGGCCGCTCTGAAAGCCTCAAGGGCCGGGAAGAG ATGAAACGGTCTCGAAAGGCAGAGAACGTGCCCCGCTCTCGCAGTGATGTTGACATGGATGCTGCTGCGGAGGCTACTCGCCTGCACCAGTCAGCCTCGT CCTCTACCTCCAGCCTCTCCACCAGGTCTCTTGAGAACCCAACCCCTCCATTCACTCCCAAAATGGGCCGCAGGAGCATTGAGTCCCCCAGTTTGGGGTT CTGCACAGATACCCTCCTTCCCCACCTCCTAGAGGATGATCTGGGCCAGCTGTCTGACCTGGAGCCAGAGCCAGATGCCCAAAATTGGCAGCATACAGTG GGCAAGGATGTGGTGGCTGGGCTAACCCAGCGGGAGATTGACCGGCAAGAGGTCATCAATGAGCTGTTTGTGACTGAAGCTTCCCACCTGCGCACACTCC GGGTCCTGGACCTGATCTTCTACCAGCGAATGAAGAAGGAGAACCTGATGCCCCGGGAGGAGCTGGCCCGGCTCTTCCCGAACCTGCCTGAACTCATAGA GATTCACAATTCCTGGTGTGAAGCCATGAAGAAGCTCCGGGAGGAAGGCCCCATCATCAAAGAGATCAGTGACCTCATGCTGGCCCGGTTTGATGGCCCT GCCCGAGAGGAACTCCAGCAAGTGGCTGCACAGTTCTGTTCCTATCAGTCAATAGCCCTAGAGCTAATCAAGACCAAGCAACGCAAGGAGAGTCGATTCC AGCTCTTCATGCAGGAGGCTGAGAGCCACCCTCAGTGTCGGCGGCTGCAGCTGAGAGACCTCATCATCTCTGAGATGCAGCGGCTCACCAAGTACCCGCT GCTGCTGGAGAGCATCATCAAGCACACAGAGGGTGGCACCTCTGAGCATGAGAAGCTGTGCCGGGCCCGGGACCAGTGCCGGGAGATTCTCAAGTATGTG AATGAAGCGGTAAAACAAACAGAGAACCGCCACCGTTTAGAGGGCTACCAGAAACGCCTGGATGCCACCGCCCTGGAGAGGGCCAGCAACCCCCTGGCAG CAGAGTTCAAGAGCCTGGATCTTACAACCAGAAAAATGATCCATGAGGGACCCCTGACCTGGAGGATCAGCAAGGATAAGACCTTGGACCTCCACGTGCT GCTGCTGGAGGACCTCCTAGTGCTGCTACAGAAACAGGATGAGAAGCTATTGCTGAAGTGCCACAGCAAGACTGCTGTGGGCTCCTCAGACAGCAAGCAG ACCTTCAGCCCCGTGCTCAAGCTCAATGCTGTGCTCATCCGCTCTGTGGCCACAGATAAACGGGCCTTCTTCATCATCTGCACCTCCAAGCTGGGCCCAC CCCAGATCTATGAGCTGGTTGCATTGACGTCATCAGACAAGAACACATGGATGGAGCTCTTAGAAGAGGCCGTGCGGAATGCCACCAGGCACCCCGGAGC TGCCCCAATGCCCGTCCATCCTCCACCCCCAGGTCCCCGGGAGCCAGCCCAGCAGGGCCCCACACCCAGCAGGGTAGAACTGGATGACTCAGACGTGTTC CATGGTGAACCTGAACCTGAGGAGCTGCCTGGAGGCACTGGGTCCCAGCAGAGGGTCCAAGGGAAGCACCAGGTCCTGCTAGAGGACCCTGAGCAGGAGG GCAGTGCAGAGGAAGAGGAACTGGGTGTCCTGCCTTGCCCTTCCACATCCCTGGATGGAGAGAACAGGGGCATCAGGACAAGGAACCCCATCCACTTGGC CTTCCCAGGCCCTCTGTTCATGGAAGGGCTCGCTGACTCCGCTCTGGAAGATGTGGAGAACCTGCGACATCTGATCCTGTGGAGCCTGCTGCCAGGTCAC ACCATGGAAACTCAGGCTGCCCAGGAGCCCGAGGACGACCTGACACCCACACCTTCTGTCATCAGCGTCACCTCTCACCCCTGGGACCCAGGCTCCCCAG GGCAAGCACCCCCTGGGGGTGAAGGGGACAACACCCAGCTTGCAGGGCTGGAGGGGGAACGGCCAGAGCAGGAAGACATGGGTCTCTGTTCTCTGGAACA CCTACCCCCAAGGACCAGAAATTCTGGGATATGGGAGTCTCCAGAACTGGACAGGAATCTGGCTGAAGATGCTTCAAGCACAGAGGCAGCAGGAGGTTAC AAAGTTGTGAGAAAAGCTGAGGTGGCAGGCAGCAAGGTTGTCCCTGCACTACCAGAGAGTGGCCAGTCAGAGCCTGGGCCACCTGAAGTGGAAGGCGGAA CAAAGGCTACGGGGAACTGCTTTTATGTCAGCATGCCATCAGGACCCCCGGACTCAAGCACCGACCACTCAGAGGCACCCATGAGCCCCCCTCAGCCTGA CAGCCTCCCTGCAGGGCAGACAGAGCCTCAGCCTCAGCTGCAGGGAGGCAACGATGATCCAAGACGCCCCAGCCGCTCTCCTCCAAGCCTGGCCCTCAGG GACGTGGGCATGATCTTCCATACCATTGAGCAGCTCACTCTCAAGCTCAACAGGCTCAAGGATATGGAGCTGGCCCACAGAGAGCTGCTCAAGTCCCTTG GGGGAGAGTCATCTGGTGGCACCACGCCTGTGGGCAGTTTCCACACAGAAGCAGCTAGATGGACAGATGGCTCCCTCTCACCTCCCGCTAAGGAGCCCCT AGCTTCTGACTCCAGGAACAGCCATGAACTGGGGCCCTGCCCTGAGGATGGCTCTGACGCCCCCCTGGAAGACAGCACAGCAGACGCAGCCGCGTCACCA GGACCATAACCGTACAAACCACCAAATCCTCTGCGTCCCCACTCCTCCTTCAGGGACTGGCCTGAGACCGGGGCACAGGGTAGGGGGGATCCCAACACTC CTCCCTGTGGAGGAGGCAGTTAGGGAAACTAGGATCCAGCCAAGGCCCGGGGGGAGACCCGCATGTTGCTTGGTCTGCTCAAGTCGGAGTCAGGTTTCAG TGTCTTTTCCCTCCCTTAGCCCAACCCTCCAAGGCCTCATGTCTCCTAAGCATGCTGACTGCATCCGAAAGGCCCCCACTCACCATGGTCTGCCCTCACC CCACATATGTGTGTACACGCGCACGCCTGTATGTGCGCTGCCCTCAGACATGCAAGTGAAAGGAGGAGGCTTCTGTGTAAATGCACTTTCTTCCTCCCCT CTTTCTCCATAAGACCCCAGGCAGAGGTGGGTGCCTCCCCTCCCCTCTTTGTCACTTTGGTTTCCTATAAATATGTATGTATCGTATGTGCATCTTTGCT ATTGTAAATAACTTTGACCTTTTTTGTTCCTGTTCCTGAAGTGCTGGAGGCAGTTATGGAAGGAGCTGCTTAGGGAAGAGGGGTTTCACTTGTATCTCCT TAGTTAACAACCCAGTTCCAGGATCGAGCCTAAAGCGGGAGCCAGGCCTGAGTGTTCCTGTCCCTGTGAGTGGGAAGGTCTTCTGGCTCCCCATCCCACC TGGCTCCAGAGCCTGCCCTCCACAGCTTGCTGCCAAGCTACTCCCTCCCTCCCTGGACTTCTCATCTTCACAAGATGGGGATCATGGGGGTTTCTTACCC CACCTATGTCCCCCTCTTCCCCACCCTGTCCCTGTAGAAAACCAGTGAAGCAGGTACGGAGCTGAGGACTGGGCCCCAGGAGGTGGGGACAGGGGTCTGA ATGCCGAGTCCCTGAATTCACCCAGGACCATCCAAGGGGCCACCGCAGCATTGGCCCCATCACCACGTCCTCACCCAACTCTCCCTGATGAATAGAATAT ACACACTGTGCTAGGTGTATATATACATATATATATATATAAATATATATATAATATATAAAATATAGATATGGAAATGACTGTTCTGCTGTTAAGATAA TGTATACTCTTTTATTTTCTTCCTTTCATGGTTAAGATTTTTTTTTTAAGAAAAGTTAAATATCCTTCA

refseq_ARHGEF11.F2 (forward primer)
refseq_ARHGEF11.R2 (reverse primer)
Single exon skipping

Frame 0

SEISVSWRLRQEKISEPGCGGAQQQN*LRKLSF RKRPNVGWV*ESGWGRWRNLQV*RKKKRREYFQR LSLVCYHYYHLKGKKHCISGVL*FLFYFFFWCN WLI*EFQNI*CKSFFFFKEVHKFWFPGLHWTWK ECCCVHTIVWFYLLFYCTNQPKEFFQVPFRIY*S FFFSFPQRYLLLSY*ALETRKLLSPFELEGLLP TEGQLRKLDLKDGFICTLQLTVIF*RHIFL*FI FFWP*C*P*RDSWLGFWFLRRS*FFLFSFFFLFS FLFFFFKAGEGKRG*ERKSCSLVEVEWSISYQG PESWRRKDSIFKLGGPPLTLLKNCKRFNPDQDT KATGFWNRGDTEKP*V*GYPRV*TG*VACLLWEI LHQSASPLPTIASLRMPLRQQVSFNAVSLSKRT SMASASQSVGIALFWCSLCGLEVQP*RPV*KRA TGSSKSTAPW*PIAHTWKW*S*SNLAPMSHSPSW ALHLHPWASLGSSRTHPQQELPESRQ*SPHHHL LHLYHLHNASQDPNLCRIPKFKNMPPRSSGIC* GRKKKNYRTYFHYMVTPARDHQKAGSLWIPRRGT VAWTLGQNAFLPSVSH**IGTRYCQTLG*TVLE PPL*SWPGWPSTTGGRARMQQSPQPVTRV*IKA QSL*LLAQRKTMTRVISTTRATSYSRIWRN*SLG QLTWGFFYVTSSLRRTPVHCFFTCVQKFISRQA PRIPEAWGKTSGIFSWRKMRL*E*RSLRCYRLK LTRACGTAKMPVVFSVKLKRQPCLRSKSRSTTTE RSAHWGWAACMVKMTCWTWMGTLSESAKWLRSS WLPLEIFCPSMRKTGAPPWTSPSIPT*AMLGSV FERHDLPTQLKRPSLLLTRTSGYRSSLRPRRAAI PRKKRMPWRTRSETLSSNTLGSPKALLKAHFIF PCPLWKSNQAM*GTSFSTLRTTSSMMPQNLGHN DSRPEAFLRTCWRVTVHAQRFAWAALKASRAGKR *NGLERQRTCPALAVMLTWMLLRRLLACTSQPR PLPPASPPGLLRTQPLHSLPKWAAGALSPPVWG SAQIPSFPTS*RMIWASCLTWSQSQMPKIGSIQW ARMWWLG*PSGRLTGKRSSMSCL*LKLPTCAHS GSWT*SSTSE*RRRT*CPGRSWPGSSRTCLNS* RFTIPGVKP*RSSGRKAPSSKRSVTSCWPGLMAL PERNSSKWLHSSVPISQ*P*S*SRPSNARRVDS SSSCRRLRATLSVGGCS*ETSSSLRCSGSPSTR CCWRASSSTQRVAPLSMRSCAGPGTSAGRFSSM* MKR*NKQRTATV*RATRNAWMPPPWRGPATPWQ QSSRAWILQPEK*SMRDP*PGGSARIRPWTSTC CCWRTS*CCYRNRMRSYC*SATARLLWAPQTASR PSAPCSSSMLCSSALWPQINGPSSSSAPPSWAH PRSMSWLH*RHQTRTHGWSS*KRPCGMPPGTPE LPQCPSILHPQVPGSQPSRAPHPAG*NWMTQTCS MVNLNLRSCLEALGPSRGSKGSTRSC*RTLSRR AVQRKRNWVSCLALPHPWMERTGASGQGTPSTW PSQALCSWKGSLTPLWKMWRTCDI*SCGACCQVT PWKLRLPRSPRTT*HPHLLSSASPLTPGTQAPQ GKHPLGVKGTTPSLQGWRGNGQSRKTWVSVLWN TYPQGPEILGYGSLQNWTGIWLKMLQAQRQQEVT KL*EKLRWQAARLSLHYQRVASQSLGHLKWKAE QRLRGTAFMSACHQDPRTQAPTTQRHP*APLSL TASLQGRQSLSLSCREATMIQDAPAALLQAWPSG TWA*SSIPLSSSLSSSTGSRIWSWPTESCSSPL GESHLVAPRLWAVSTQKQLDGQMAPSHLPLRSP *LLTPGTAMNWGPALRMALTPPWKTAQQTQPRHQ DHNRTNHQILCVPTPPSGTGLRPGHRVGGIPTL LPVEEAVRETRIQPRPGGRPACCLVCSSRSQVS VSFPSLSPTLQGLMSPKHADCIRKAPTHHGLPSP HICVYTRTPVCALPSDMQVKGGGFCVNALSSSP LSP*DPRQRWVPPLPSLSLWFPINMYVSYVHLC YCK*L*PFLFLFLKCWRQLWKELLREEGFHLYLL S*QPSSRIEPKAGARPECSCPCEWEGLLAPHPT WLQSLPSTACCQATPSLPGLLIFTRWGSWGFLT PPMSPSSPPCPCRKPVKQVRS*GLGPRRWGQGSE CRVPEFTQDHPRGHRSIGPITTSSPNSP**IEY THCARCIYTYIYI*IYI*YIKYRYGNDCSAVKI MYTLLFSSFHG*DFFFKKS*ISF

Frame 1

AKSPFHGG*GKRKFRSLDVEEPNSRTNSGNCLS EKGRT*AGSENQAGVGGGTCKFKGKRKGENIFR DYLWFVIITTILKVKSIAFQVFFDFYFIFFFGAI GSFKNFKTFNVKAFFFLRKSINFGSQGCTGLGR SAVVYILLYGFIYYFTVQISRKNFSKCHFGFIN PFFFPFLKDICCCHIKHWRLENYFPPLS*RVSCQ QKDS*ESWI*RMVLSVLCS*Q*YFEGTFFCDSF FFGHSANLEEIRGWVFGF*EGRSFSSFPFFFFF LFFSFFLKRGRGRGAEKGNHVHW*K*SGASVTRV LRAGGERILSSSWEALLSPCSKIASDSILIKTP KLQDSGTVETPRNHECKVTPEYRQVK*PVFSGR FCTRAQVPFPPSPAFGCL*DNRSRSTLCHYPKGP AWLRLHSQWGSHCSGAVCAAWRCSHEGRCERGR PDHQSQRHHGDQ*LTPGSGKADQIWRLCRTHPP GLFTFIHGHLWAPAGPIPSRSSPNHVSDPLTTTS STSTTSTTHHRTQTSAGSRSSKTCHPDPQEYAE AGRKRITGHTSTIW*HQPETIRRPALSGFPGGG QWLGLWDRTLSFPQ*VIDESELGTVRPWARQSSN LPCDHGQGGPAPQAAGLGCSSPLNR*PGCRSKP KAFNYWPRGRL*PGLFQQRERHHIPGSGETEVS ASSPGGFSTLHLLSGGPQSTAFLPVCRSLSAGKP QGFPKLGERHLEYFPGEKCASESEDP*DATG*N *LAPAEQRRCPWCSL*SSRGSHA*DPRADPRLQ NEAHTGAGQPVW*K*PAGPGWGPSPRAPSG*EAA GCPWRYFVQV*GRQERPHGLRPQYLHEPCWDPS SRGTTFQHS*KGPVCS*QGQVATVLP*DQEEQQ FQERKGCLGGQEAKPYPQIHWEAQKLFSKHISYS LVPCGSQTRQCEEHHSAL*EQPAV*CPRTWDTT TLDRKLS*GPAGE*QFTLRDSPGPL*KPQGPGR DETVSKGRERAPLSQ*C*HGCCCGGYSPAPVSLV LYLQPLHQVS*EPNPSIHSQNGPQEH*VPQFGV LHRYPPSPPPRG*SGPAV*PGARARCPKLAAYS GQGCGGWANPAGD*PARGHQ*AVCD*SFPPAHTP GPGPDLLPANEEGEPDAPGGAGPALPEPA*THR DSQFLV*SHEEAPGGRPHHQRDQ*PHAGPV*WP CPRGTPASGCTVLFLSVNSPRANQDQATQGESIP ALHAGG*EPPSVSAAAAERPHHL*DAAAHQVPA AAGEHHQAHRGWHL*A*EAVPGPGPVPGDSQVC E*SGKTNREPPPFRGLPETPGCHRPGEGQQPPGS RVQEPGSYNQKNDP*GTPDLEDQQG*DLGPPRA AAGGPPSAATETG*EAIAEVPQQDCCGLLRQQA DLQPRAQAQCCAHPLCGHR*TGLLHHLHLQAGPT PDL*AGCIDVIRQEHMDGALRRGRAECHQAPRS CPNARPSSTPRSPGASPAGPHTQQGRTG*LRRV PW*T*T*GAAWRHWVPAEGPREAPGPARGP*AGG QCRGRGTGCPALPFHIPGWREQGHQDKEPHPLG LPRPSVHGRAR*LRSGRCGEPATSDPVEPAARS HHGNSGCPGARGRPDTHTFCHQRHLSPLGPRLPR ASTPWG*RGQHPACRAGGGTARAGRHGSLFSGT PTPKDQKFWDMGVSRTGQESG*RCFKHRGSRRL QSCEKS*GGRQQGCPCTTREWPVRAWAT*SGRRN KGYGELLLCQHAIRTPGLKHRPLRGTHEPPSA* QPPCRADRASASAAGRQR*SKTPQPLSSKPGPQ GRGHDLPYH*AAHSQAQQAQGYGAGPQRAAQVPW GRVIWWHHACGQFPHRSS*MDRWLPLTSR*GAP SF*LQEQP*TGALP*GWL*RPPGRQHSRRSRVT RTITVQTTKSSASPLLLQGLA*DRGTG*GGSQHS SLWRRQLGKLGSSQGPGGDPHVAWSAQVGVRFQ CLFPPLAQPSKASCLLSMLTASERPPLTMVCPH PTYVCTRARLYVRCPQTCK*KEEASV*MHFLPPL FLHKTPGRGGCLPSPLCHFGFL*ICMYRMCIFA IVNNFDLFCSCS*SAGGSYGRSCLGKRGFTCIS LVNNPVPGSSLKREPGLSVPVPVSGKVFWLPIPP GSRACPPQLAAKLLPPSLDFSSSQDGDHGGFLP HLCPPLPHPVPVENQ*SRYGAEDWAPGGGDRGL NAESLNSPRTIQGATAALAPSPRPHPTLPDE*NI HTVLGVYIHIYIYKYIYNI*NIDMEMTVLLLR* CILFYFLPFMVKIFFLRKVKYPS

Frame 2

RNLRFMEAEARENFGAWMWRSPTAELTQEIVFQ KKAERRLGLRIRLG*VEEPASLKEKEKERIFSE IISGLLSLLPS*R*KALHFRCSLIFILFFFLVQ LAHLRISKHLM*KLFFF*GSP*ILVPRVALDLEG VLLCTYYCMVLFIILLYKSAERIFPSAISDLLI LFFFLSSKIFAVVILSIGD*KITFPL*ARGSLA NRRTAEKAGFKGWFYLYFAVNSDILKAHFSVIHF FLAIVLTLKRFVAGFLVSEKVVVFPLFLFFSFF FSFLFF*SGGGEEGLRKEIMFTGRSRVEHQLPG S*ELEEKGFYLQVGRPSSHLAQKLQAIQS*SRHQ SYRILEPWRHRETMSVRLPQSIDRLSSLSSLGD SAPERKSPSHHRQPSDASETTGLVQRCVIIQKD QHGFGFTVSGDRIVLVQSVRPGGAAMKAGVKEGD RIIKVNGTMVTNSSHLEVVKLIKSGAYVALTLL GSSPSSMGISGLQQDPSPAGAPRITSVIPSPPP PPPLPPPQRITGPKPLQDPEVQKHATQILRNMLR QEEKELQDILPLYGDTSQRPSEGRLSLDSQEGD SGLDSGTERFPSLSESLMNRNSVLSDPGLDSPR TSPVIMARVAQHHRRQGSDAAVPSTGDQGVDQSP KPLIIGPEEDYDPGYFNNESDIIFQDLEKLKSR PAHLGVFLRYIFSQADPSPLLFYLCAEVYQQAS PKDSRSLGKDIWNIFLEKNAPLRVKIPEMLQAEI DSRLRNSEDARGVLCEAQEAAMPEIQEQIHDYR TKRTLGLGSLYGENDLLDLDGDPLRERQVAEKQ LAALGDILSKYEEDRSAPMDFALNTYMSHAGIRL REARPSNTAEKAQSAPDKDKWLPFFPKTKKSSN SKKEKDALEDKKRNPILKYIGKPKSSSQSTFHI PLSPVEVKPGNVRNIIQHFENNQQYDAPEPGTQR LSTGSFPEDLLESDSSRSEIRLGRSESLKGREE MKRSRKAENVPRSRSDVDMDAAAEATRLHQSAS SSTSSLSTRSLENPTPPFTPKMGRRSIESPSLGF CTDTLLPHLLEDDLGQLSDLEPEPDAQNWQHTV GKDVVAGLTQREIDRQEVINELFVTEASHLRTL RVLDLIFYQRMKKENLMPREELARLFPNLPELIE IHNSWCEAMKKLREEGPIIKEISDLMLARFDGP AREELQQVAAQFCSYQSIALELIKTKQRKESRF QLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPL LLESIIKHTEGGTSEHEKLCRARDQCREILKYV NEAVKQTENRHRLEGYQKRLDATALERASNPLA AEFKSLDLTTRKMIHEGPLTWRISKDKTLDLHVL LLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQ TFSPVLKLNAVLIRSVATDKRAFFIICTSKLGP PQIYELVALTSSDKNTWMELLEEAVRNATRHPGA APMPVHPPPPGPREPAQQGPTPSRVELDDSDVF HGEPEPEELPGGTGSQQRVQGKHQVLLEDPEQE GSAEEEELGVLPCPSTSLDGENRGIRTRNPIHLA FPGPLFMEGLADSALEDVENLRHLILWSLLPGH TMETQAAQEPEDDLTPTPSVISVTSHPWDPGSP GQAPPGGEGDNTQLAGLEGERPEQEDMGLCSLEH LPPRTRNSGIWESPELDRNLAEDASSTEAAGGY KVVRKAEVAGSKVVPALPESGQSEPGPPEVEGG TKATGNCFYVSMPSGPPDSSTDHSEAPMSPPQPD SLPAGQTEPQPQLQGGNDDPRRPSRSPPSLALR DVGMIFHTIEQLTLKLNRLKDMELAHRELLKSL GGESSGGTTPVGSFHTEAARWTDGSLSPPAKEPL ASDSRNSHELGPCPEDGSDAPLEDSTADAAASP GP*PYKPPNPLRPHSSFRDWPETGAQGRGDPNT PPCGGGS*GN*DPAKARGETRMLLGLLKSESGFS VFSLP*PNPPRPHVS*AC*LHPKGPHSPWSALT PHMCVHAHACMCAALRHASERRRLLCKCTFFLP SFSIRPQAEVGASPPLFVTLVSYKYVCIVCASLL L*ITLTFFVPVPEVLEAVMEGAA*GRGVSLVSP *LTTQFQDRA*SGSQA*VFLSL*VGRSSGSPSH LAPEPALHSLLPSYSLPPWTSHLHKMGIMGVSYP TYVPLFPTLSL*KTSEAGTELRTGPQEVGTGV* MPSP*IHPGPSKGPPQHWPHHHVLTQLSLMNRI YTLC*VYIYIYIYINIYIIYKI*IWK*LFCC*DN VYSFIFFLSWLRFFF*EKLNIL

Sequence NM_198236

AGCGAAATCTCCGTTTCATGGAGGCTGAGGCAAGAGAAAATTTCGGAGCCTGGATGTGGAGGAGCCCAACAGCAGAACTAACTCAGGAAATTGTCTTTCA GAAAAAGGCCGAACGTAGGCTGGGTCTGAGAATCAGGCTGGGGTAGGTGGAGGAACCTGCAAGTTTAAAGGAAAAAGAAAAGGAGAGAATATTTTCAGAG ATTATCTCTGGTTTGTTATCATTACTACCATCTTAAAGGTAAAAAGCATTGCATTTCAGGTGTTCTTTGATTTTTATTTTATTTTTTTTTTTGGTGCAAT TGGCTCATTTAAGAATTTCAAAACATTTAATGTAAAAGCTTTTTTTTTTTTAAGGAAGTCCATAAATTTTGGTTCCCAGGGTTGCACTGGACTTGGAAGG AGTGCTGTTGTGTACATACTATTGTATGGTTTTATTTATTATTTTACTGTACAAATCAGCCGAAAGAATTTTTCCAAGTGCCATTTCGGATTTATTAATC CTTTTTTTTTTCCTTTCCTCAAAGATATTTGCTGTTGTCATATTAAGCATTGGAGACTAGAAAATTACTTTCCCCCTTTGAGCTAGAGGGTCTCTTGCCA ACAGAAGGACAGCTGAGAAAGCTGGATTTAAAGGATGGTTTTATCTGTACTTTGCAGTTAACAGTGATATTTTGAAGGCACATTTTTCTGTGATTCATTT TTTTTTGGCCATAGTGCTAACCTTGAAGAGATTCGTGGCTGGGTTTTTGGTTTCTGAGAAGGTCGTAGTTTTTCCTCTTTTCCTTTTTTTTTCTTTTTTC TTTTCTTTTCTTTTTTTTTAAAGCGGGGGAGGGGAAGAGGGGCTGAGAAAGGAAATCATGTTCACTGGTAGAAGTAGAGTGGAGCATCAGTTACCAGGGT CCTGAGAGCTGGAGGAGAAAGGATTCTATCTTCAAGTTGGGAGGCCCTCCTCTCACCTTGCTCAAAAATTGCAAGCGATTCAATCCTGATCAAGACACCA AAGCTACAGGATTCTGGAACCGTGGAGACACCGAGAAACCATGAGTGTAAGGTTACCCCAGAGTATAGACAGGTTAAGTAGCCTGTCTTCTCTGGGAGAT TCTGCACCAGAGCGCAAGTCCCCTTCCCACCATCGCCAGCCTTCGGATGCCTCTGAGACAACAGGTCTCGTTCAACGCTGTGTCATTATCCAAAAGGACC AGCATGGCTTCGGCTTCACAGTCAGTGGGGATCGCATTGTTCTGGTGCAGTCTGTGCGGCCTGGAGGTGCAGCCATGAAGGCCGGTGTGAAAGAGGGCGA CCGGATCATCAAAGTCAACGGCACCATGGTGACCAATAGCTCACACCTGGAAGTGGTAAAGCTGATCAAATCTGGCGCCTATGTCGCACTCACCCTCCTG GGCTCTTCACCTTCATCCATGGGCATCTCTGGGCTCCAGCAGGACCCATCCCCAGCAGGAGCTCCCCGAATCACGTCAGTGATCCCCTCACCACCACCTC CTCCACCTCTACCACCTCCACAACGCATCACAGGACCCAAACCTCTGCAGGATCCCGAAGTTCAAAAACATGCCACCCAGATCCTCAGGAATATGCTGAG GCAGGAAGAAAAAGAATTACAGCGTATCTGTGAGGTCTATAGCCGGAACCCCGCCAGCCTACTGGAAGAGCAGATCGAAGGTGCCCGGCGGCGAGTCACT CAGTTACAGCTGAAGATCCAGCAGGAGACTGGTGGCTCAGTGGACATACTTCCACTATATGGTGACACCAGCCAGAGACCATCAGAAGGCCGGCTCTCTC TGGATTCCCAGGAGGGGGACAGTGGCTTGGACTCTGGGACAGAACGCTTTCCTTCCCTCAGTGAGTCATTGATGAATCGGAACTCGGTACTGTCAGACCC TGGGCTAGACAGTCCTCGAACCTCCCCTGTGATCATGGCCAGGGTGGCCCAGCACCACAGGCGGCAGGGCTCGGATGCAGCAGTCCCCTCAACCGGTGAC CAGGGTGTAGATCAAAGCCCAAAGCCTTTAATTATTGGCCCAGAGGAAGACTATGACCCGGGTTATTTCAACAACGAGAGCGACATCATATTCCAGGATC TGGAGAAACTGAAGTCTCGGCCAGCTCACCTGGGGGTTTTTCTACGTTACATCTTCTCTCAGGCGGACCCCAGTCCACTGCTTTTTTACCTGTGTGCAGA AGTTTATCAGCAGGCAAGCCCCAAGGATTCCCGAAGCTTGGGGAAAGACATCTGGAATATTTTCCTGGAGAAAAATGCGCCTCTGAGAGTGAAGATCCCT GAGATGCTACAGGCTGAAATTGACTCGCGCCTGCGGAACAGCGAAGATGCCCGTGGTGTTCTCTGTGAAGCTCAAGAGGCAGCCATGCCTGAGATCCAAG AGCAGATCCACGACTACAGAACGAAGCGCACACTGGGGCTGGGCAGCCTGTATGGTGAAAATGACCTGCTGGACCTGGATGGGGACCCTCTCCGAGAGCG CCAAGTGGCTGAGAAGCAGCTGGCTGCCCTTGGAGATATTTTGTCCAAGTATGAGGAAGACAGGAGCGCCCCCATGGACTTCGCCCTCAATACCTACATG AGCCATGCTGGGATCCGTCTTCGAGAGGCACGACCTTCCAACACAGCTGAAAAGGCCCAGTCTGCTCCTGACAAGGACAAGTGGCTACCGTTCTTCCCTA AGACCAAGAAGAGCAGCAATTCCAAGAAAGAAAAGGATGCCTTGGAGGACAAGAAGCGAAACCCTATCCTCAAATACATTGGGAAGCCCAAAAGCTCTTC TCAAAGCACATTTCATATTCCCTTGTCCCCTGTGGAAGTCAAACCAGGCAATGTGAGGAACATCATTCAGCACTTTGAGAACAACCAGCAGTATGATGCC CCAGAACCTGGGACACAACGACTCTCGACCGGAAGCTTTCCTGAGGACCTGCTGGAGAGTGACAGTTCACGCTCAGAGATTCGCCTGGGCCGCTCTGAAA GCCTCAAGGGCCGGGAAGAGATGAAACGGTCTCGAAAGGCAGAGAACGTGCCCCGCTCTCGCAGTGATGTTGACATGGATGCTGCTGCGGAGGCTACTCG CCTGCACCAGTCAGCCTCGTCCTCTACCTCCAGCCTCTCCACCAGGTCTCTTGAGAACCCAACCCCTCCATTCACTCCCAAAATGGGCCGCAGGAGCATT GAGTCCCCCAGTTTGGGGTTCTGCACAGATACCCTCCTTCCCCACCTCCTAGAGGATGATCTGGGCCAGCTGTCTGACCTGGAGCCAGAGCCAGATGCCC AAAATTGGCAGCATACAGTGGGCAAGGATGTGGTGGCTGGGCTAACCCAGCGGGAGATTGACCGGCAAGAGGTCATCAATGAGCTGTTTGTGACTGAAGC TTCCCACCTGCGCACACTCCGGGTCCTGGACCTGATCTTCTACCAGCGAATGAAGAAGGAGAACCTGATGCCCCGGGAGGAGCTGGCCCGGCTCTTCCCG AACCTGCCTGAACTCATAGAGATTCACAATTCCTGGTGTGAAGCCATGAAGAAGCTCCGGGAGGAAGGCCCCATCATCAAAGAGATCAGTGACCTCATGC TGGCCCGGTTTGATGGCCCTGCCCGAGAGGAACTCCAGCAAGTGGCTGCACAGTTCTGTTCCTATCAGTCAATAGCCCTAGAGCTAATCAAGACCAAGCA ACGCAAGGAGAGTCGATTCCAGCTCTTCATGCAGGAGGCTGAGAGCCACCCTCAGTGTCGGCGGCTGCAGCTGAGAGACCTCATCATCTCTGAGATGCAG CGGCTCACCAAGTACCCGCTGCTGCTGGAGAGCATCATCAAGCACACAGAGGGTGGCACCTCTGAGCATGAGAAGCTGTGCCGGGCCCGGGACCAGTGCC GGGAGATTCTCAAGTATGTGAATGAAGCGGTAAAACAAACAGAGAACCGCCACCGTTTAGAGGGCTACCAGAAACGCCTGGATGCCACCGCCCTGGAGAG GGCCAGCAACCCCCTGGCAGCAGAGTTCAAGAGCCTGGATCTTACAACCAGAAAAATGATCCATGAGGGACCCCTGACCTGGAGGATCAGCAAGGATAAG ACCTTGGACCTCCACGTGCTGCTGCTGGAGGACCTCCTAGTGCTGCTACAGAAACAGGATGAGAAGCTATTGCTGAAGTGCCACAGCAAGACTGCTGTGG GCTCCTCAGACAGCAAGCAGACCTTCAGCCCCGTGCTCAAGCTCAATGCTGTGCTCATCCGCTCTGTGGCCACAGATAAACGGGCCTTCTTCATCATCTG CACCTCCAAGCTGGGCCCACCCCAGATCTATGAGCTGGTTGCATTGACGTCATCAGACAAGAACACATGGATGGAGCTCTTAGAAGAGGCCGTGCGGAAT GCCACCAGGCACCCCGGAGCTGCCCCAATGCCCGTCCATCCTCCACCCCCAGGTCCCCGGGAGCCAGCCCAGCAGGGCCCCACACCCAGCAGGGTAGAAC TGGATGACTCAGACGTGTTCCATGGTGAACCTGAACCTGAGGAGCTGCCTGGAGGCACTGGGTCCCAGCAGAGGGTCCAAGGGAAGCACCAGGTCCTGCT AGAGGACCCTGAGCAGGAGGGCAGTGCAGAGGAAGAGGAACTGGGTGTCCTGCCTTGCCCTTCCACATCCCTGGATGGAGAGAACAGGGGCATCAGGACA AGGAACCCCATCCACTTGGCCTTCCCAGGCCCTCTGTTCATGGAAGGGCTCGCTGACTCCGCTCTGGAAGATGTGGAGAACCTGCGACATCTGATCCTGT GGAGCCTGCTGCCAGGTCACACCATGGAAACTCAGGCTGCCCAGGAGCCCGAGGACGACCTGACACCCACACCTTCTGTCATCAGCGTCACCTCTCACCC CTGGGACCCAGGCTCCCCAGGGCAAGCACCCCCTGGGGGTGAAGGGGACAACACCCAGCTTGCAGGGCTGGAGGGGGAACGGCCAGAGCAGGAAGACATG GGTCTCTGTTCTCTGGAACACCTACCCCCAAGGACCAGAAATTCTGGGATATGGGAGTCTCCAGAACTGGACAGGAATCTGGCTGAAGATGCTTCAAGCA CAGAGGCAGCAGGAGGTTACAAAGTTGTGAGAAAAGCTGAGGTGGCAGGCAGCAAGGTTGTCCCTGCACTACCAGAGAGTGGCCAGTCAGAGCCTGGGCC ACCTGAAGTGGAAGGCGGAACAAAGGCTACGGGGAACTGCTTTTATGTCAGCATGCCATCAGGACCCCCGGACTCAAGCACCGACCACTCAGAGGCACCC ATGAGCCCCCCTCAGCCTGACAGCCTCCCTGCAGGGCAGACAGAGCCTCAGCCTCAGCTGCAGGGAGGCAACGATGATCCAAGACGCCCCAGCCGCTCTC CTCCAAGCCTGGCCCTCAGGGACGTGGGCATGATCTTCCATACCATTGAGCAGCTCACTCTCAAGCTCAACAGGCTCAAGGATATGGAGCTGGCCCACAG AGAGCTGCTCAAGTCCCTTGGGGGAGAGTCATCTGGTGGCACCACGCCTGTGGGCAGTTTCCACACAGAAGCAGCTAGATGGACAGATGGCTCCCTCTCA CCTCCCGCTAAGGAGCCCCTAGCTTCTGACTCCAGGAACAGCCATGAACTGGGGCCCTGCCCTGAGGATGGCTCTGACGCCCCCCTGGAAGACAGCACAG CAGACGCAGCCGCGTCACCAGGACCATAACCGTACAAACCACCAAATCCTCTGCGTCCCCACTCCTCCTTCAGGGACTGGCCTGAGACCGGGGCACAGGG TAGGGGGGATCCCAACACTCCTCCCTGTGGAGGAGGCAGTTAGGGAAACTAGGATCCAGCCAAGGCCCGGGGGGAGACCCGCATGTTGCTTGGTCTGCTC AAGTCGGAGTCAGGTTTCAGTGTCTTTTCCCTCCCTTAGCCCAACCCTCCAAGGCCTCATGTCTCCTAAGCATGCTGACTGCATCCGAAAGGCCCCCACT CACCATGGTCTGCCCTCACCCCACATATGTGTGTACACGCGCACGCCTGTATGTGCGCTGCCCTCAGACATGCAAGTGAAAGGAGGAGGCTTCTGTGTAA ATGCACTTTCTTCCTCCCCTCTTTCTCCATAAGACCCCAGGCAGAGGTGGGTGCCTCCCCTCCCCTCTTTGTCACTTTGGTTTCCTATAAATATGTATGT ATCGTATGTGCATCTTTGCTATTGTAAATAACTTTGACCTTTTTTGTTCCTGTTCCTGAAGTGCTGGAGGCAGTTATGGAAGGAGCTGCTTAGGGAAGAG GGGTTTCACTTGTATCTCCTTAGTTAACAACCCAGTTCCAGGATCGAGCCTAAAGCGGGAGCCAGGCCTGAGTGTTCCTGTCCCTGTGAGTGGGAAGGTC TTCTGGCTCCCCATCCCACCTGGCTCCAGAGCCTGCCCTCCACAGCTTGCTGCCAAGCTACTCCCTCCCTCCCTGGACTTCTCATCTTCACAAGATGGGG ATCATGGGGGTTTCTTACCCCACCTATGTCCCCCTCTTCCCCACCCTGTCCCTGTAGAAAACCAGTGAAGCAGGTACGGAGCTGAGGACTGGGCCCCAGG AGGTGGGGACAGGGGTCTGAATGCCGAGTCCCTGAATTCACCCAGGACCATCCAAGGGGCCACCGCAGCATTGGCCCCATCACCACGTCCTCACCCAACT CTCCCTGATGAATAGAATATACACACTGTGCTAGGTGTATATATACATATATATATATATAAATATATATATAATATATAAAATATAGATATGGAAATGA CTGTTCTGCTGTTAAGATAATGTATACTCTTTTATTTTCTTCCTTTCATGGTTAAGATTTTTTTTTTAAGAAAAGTTAAATATCCTTCA

refseq_ARHGEF11.F2 (forward primer)
refseq_ARHGEF11.R2 (reverse primer)
Single exon skipping

Frame 0

SEISVSWRLRQEKISEPGCGGAQQQN*LRKLSF RKRPNVGWV*ESGWGRWRNLQV*RKKKRREYFQR LSLVCYHYYHLKGKKHCISGVL*FLFYFFFWCN WLI*EFQNI*CKSFFFFKEVHKFWFPGLHWTWK ECCCVHTIVWFYLLFYCTNQPKEFFQVPFRIY*S FFFSFPQRYLLLSY*ALETRKLLSPFELEGLLP TEGQLRKLDLKDGFICTLQLTVIF*RHIFL*FI FFWP*C*P*RDSWLGFWFLRRS*FFLFSFFFLFS FLFFFFKAGEGKRG*ERKSCSLVEVEWSISYQG PESWRRKDSIFKLGGPPLTLLKNCKRFNPDQDT KATGFWNRGDTEKP*V*GYPRV*TG*VACLLWEI LHQSASPLPTIASLRMPLRQQVSFNAVSLSKRT SMASASQSVGIALFWCSLCGLEVQP*RPV*KRA TGSSKSTAPW*PIAHTWKW*S*SNLAPMSHSPSW ALHLHPWASLGSSRTHPQQELPESRQ*SPHHHL LHLYHLHNASQDPNLCRIPKFKNMPPRSSGIC* GRKKKNYSVSVRSIAGTPPAYWKSRSKVPGGESL SYS*RSSRRLVAQWTYFHYMVTPARDHQKAGSL WIPRRGTVAWTLGQNAFLPSVSH**IGTRYCQT LG*TVLEPPL*SWPGWPSTTGGRARMQQSPQPVT RV*IKAQSL*LLAQRKTMTRVISTTRATSYSRI WRN*SLGQLTWGFFYVTSSLRRTPVHCFFTCVQ KFISRQAPRIPEAWGKTSGIFSWRKMRL*E*RSL RCYRLKLTRACGTAKMPVVFSVKLKRQPCLRSK SRSTTTERSAHWGWAACMVKMTCWTWMGTLSES AKWLRSSWLPLEIFCPSMRKTGAPPWTSPSIPT* AMLGSVFERHDLPTQLKRPSLLLTRTSGYRSSL RPRRAAIPRKKRMPWRTRSETLSSNTLGSPKAL LKAHFIFPCPLWKSNQAM*GTSFSTLRTTSSMMP QNLGHNDSRPEAFLRTCWRVTVHAQRFAWAALK ASRAGKR*NGLERQRTCPALAVMLTWMLLRRLL ACTSQPRPLPPASPPGLLRTQPLHSLPKWAAGAL SPPVWGSAQIPSFPTS*RMIWASCLTWSQSQMP KIGSIQWARMWWLG*PSGRLTGKRSSMSCL*LK LPTCAHSGSWT*SSTSE*RRRT*CPGRSWPGSSR TCLNS*RFTIPGVKP*RSSGRKAPSSKRSVTSC WPGLMALPERNSSKWLHSSVPISQ*P*S*SRPS NARRVDSSSSCRRLRATLSVGGCS*ETSSSLRCS GSPSTRCCWRASSSTQRVAPLSMRSCAGPGTSA GRFSSM*MKR*NKQRTATV*RATRNAWMPPPWR GPATPWQQSSRAWILQPEK*SMRDP*PGGSARIR PWTSTCCCWRTS*CCYRNRMRSYC*SATARLLW APQTASRPSAPCSSSMLCSSALWPQINGPSSSS APPSWAHPRSMSWLH*RHQTRTHGWSS*KRPCGM PPGTPELPQCPSILHPQVPGSQPSRAPHPAG*N WMTQTCSMVNLNLRSCLEALGPSRGSKGSTRSC *RTLSRRAVQRKRNWVSCLALPHPWMERTGASGQ GTPSTWPSQALCSWKGSLTPLWKMWRTCDI*SC GACCQVTPWKLRLPRSPRTT*HPHLLSSASPLT PGTQAPQGKHPLGVKGTTPSLQGWRGNGQSRKTW VSVLWNTYPQGPEILGYGSLQNWTGIWLKMLQA QRQQEVTKL*EKLRWQAARLSLHYQRVASQSLG HLKWKAEQRLRGTAFMSACHQDPRTQAPTTQRHP *APLSLTASLQGRQSLSLSCREATMIQDAPAAL LQAWPSGTWA*SSIPLSSSLSSSTGSRIWSWPT ESCSSPLGESHLVAPRLWAVSTQKQLDGQMAPSH LPLRSP*LLTPGTAMNWGPALRMALTPPWKTAQ QTQPRHQDHNRTNHQILCVPTPPSGTGLRPGHR VGGIPTLLPVEEAVRETRIQPRPGGRPACCLVCS SRSQVSVSFPSLSPTLQGLMSPKHADCIRKAPT HHGLPSPHICVYTRTPVCALPSDMQVKGGGFCV NALSSSPLSP*DPRQRWVPPLPSLSLWFPINMYV SYVHLCYCK*L*PFLFLFLKCWRQLWKELLREE GFHLYLLS*QPSSRIEPKAGARPECSCPCEWEG LLAPHPTWLQSLPSTACCQATPSLPGLLIFTRWG SWGFLTPPMSPSSPPCPCRKPVKQVRS*GLGPR RWGQGSECRVPEFTQDHPRGHRSIGPITTSSPN SP**IEYTHCARCIYTYIYI*IYI*YIKYRYGND CSAVKIMYTLLFSSFHG*DFFFKKS*ISF

Frame 1

AKSPFHGG*GKRKFRSLDVEEPNSRTNSGNCLS EKGRT*AGSENQAGVGGGTCKFKGKRKGENIFR DYLWFVIITTILKVKSIAFQVFFDFYFIFFFGAI GSFKNFKTFNVKAFFFLRKSINFGSQGCTGLGR SAVVYILLYGFIYYFTVQISRKNFSKCHFGFIN PFFFPFLKDICCCHIKHWRLENYFPPLS*RVSCQ QKDS*ESWI*RMVLSVLCS*Q*YFEGTFFCDSF FFGHSANLEEIRGWVFGF*EGRSFSSFPFFFFF LFFSFFLKRGRGRGAEKGNHVHW*K*SGASVTRV LRAGGERILSSSWEALLSPCSKIASDSILIKTP KLQDSGTVETPRNHECKVTPEYRQVK*PVFSGR FCTRAQVPFPPSPAFGCL*DNRSRSTLCHYPKGP AWLRLHSQWGSHCSGAVCAAWRCSHEGRCERGR PDHQSQRHHGDQ*LTPGSGKADQIWRLCRTHPP GLFTFIHGHLWAPAGPIPSRSSPNHVSDPLTTTS STSTTSTTHHRTQTSAGSRSSKTCHPDPQEYAE AGRKRITAYL*GL*PEPRQPTGRADRRCPAASH SVTAEDPAGDWWLSGHTSTIW*HQPETIRRPALS GFPGGGQWLGLWDRTLSFPQ*VIDESELGTVRP WARQSSNLPCDHGQGGPAPQAAGLGCSSPLNR* PGCRSKPKAFNYWPRGRL*PGLFQQRERHHIPGS GETEVSASSPGGFSTLHLLSGGPQSTAFLPVCR SLSAGKPQGFPKLGERHLEYFPGEKCASESEDP *DATG*N*LAPAEQRRCPWCSL*SSRGSHA*DPR ADPRLQNEAHTGAGQPVW*K*PAGPGWGPSPRA PSG*EAAGCPWRYFVQV*GRQERPHGLRPQYLH EPCWDPSSRGTTFQHS*KGPVCS*QGQVATVLP* DQEEQQFQERKGCLGGQEAKPYPQIHWEAQKLF SKHISYSLVPCGSQTRQCEEHHSAL*EQPAV*C PRTWDTTTLDRKLS*GPAGE*QFTLRDSPGPL*K PQGPGRDETVSKGRERAPLSQ*C*HGCCCGGYS PAPVSLVLYLQPLHQVS*EPNPSIHSQNGPQEH *VPQFGVLHRYPPSPPPRG*SGPAV*PGARARCP KLAAYSGQGCGGWANPAGD*PARGHQ*AVCD*S FPPAHTPGPGPDLLPANEEGEPDAPGGAGPALP EPA*THRDSQFLV*SHEEAPGGRPHHQRDQ*PHA GPV*WPCPRGTPASGCTVLFLSVNSPRANQDQA TQGESIPALHAGG*EPPSVSAAAAERPHHL*DA AAHQVPAAAGEHHQAHRGWHL*A*EAVPGPGPVP GDSQVCE*SGKTNREPPPFRGLPETPGCHRPGE GQQPPGSRVQEPGSYNQKNDP*GTPDLEDQQG* DLGPPRAAAGGPPSAATETG*EAIAEVPQQDCCG LLRQQADLQPRAQAQCCAHPLCGHR*TGLLHHL HLQAGPTPDL*AGCIDVIRQEHMDGALRRGRAE CHQAPRSCPNARPSSTPRSPGASPAGPHTQQGRT G*LRRVPW*T*T*GAAWRHWVPAEGPREAPGPA RGP*AGGQCRGRGTGCPALPFHIPGWREQGHQD KEPHPLGLPRPSVHGRAR*LRSGRCGEPATSDPV EPAARSHHGNSGCPGARGRPDTHTFCHQRHLSP LGPRLPRASTPWG*RGQHPACRAGGGTARAGRH GSLFSGTPTPKDQKFWDMGVSRTGQESG*RCFKH RGSRRLQSCEKS*GGRQQGCPCTTREWPVRAWA T*SGRRNKGYGELLLCQHAIRTPGLKHRPLRGT HEPPSA*QPPCRADRASASAAGRQR*SKTPQPLS SKPGPQGRGHDLPYH*AAHSQAQQAQGYGAGPQ RAAQVPWGRVIWWHHACGQFPHRSS*MDRWLPL TSR*GAPSF*LQEQP*TGALP*GWL*RPPGRQHS RRSRVTRTITVQTTKSSASPLLLQGLA*DRGTG *GGSQHSSLWRRQLGKLGSSQGPGGDPHVAWSA QVGVRFQCLFPPLAQPSKASCLLSMLTASERPPL TMVCPHPTYVCTRARLYVRCPQTCK*KEEASV* MHFLPPLFLHKTPGRGGCLPSPLCHFGFL*ICM YRMCIFAIVNNFDLFCSCS*SAGGSYGRSCLGKR GFTCISLVNNPVPGSSLKREPGLSVPVPVSGKV FWLPIPPGSRACPPQLAAKLLPPSLDFSSSQDG DHGGFLPHLCPPLPHPVPVENQ*SRYGAEDWAPG GGDRGLNAESLNSPRTIQGATAALAPSPRPHPT LPDE*NIHTVLGVYIHIYIYKYIYNI*NIDMEM TVLLLR*CILFYFLPFMVKIFFLRKVKYPS

Frame 2

RNLRFMEAEARENFGAWMWRSPTAELTQEIVFQ KKAERRLGLRIRLG*VEEPASLKEKEKERIFSE IISGLLSLLPS*R*KALHFRCSLIFILFFFLVQ LAHLRISKHLM*KLFFF*GSP*ILVPRVALDLEG VLLCTYYCMVLFIILLYKSAERIFPSAISDLLI LFFFLSSKIFAVVILSIGD*KITFPL*ARGSLA NRRTAEKAGFKGWFYLYFAVNSDILKAHFSVIHF FLAIVLTLKRFVAGFLVSEKVVVFPLFLFFSFF FSFLFF*SGGGEEGLRKEIMFTGRSRVEHQLPG S*ELEEKGFYLQVGRPSSHLAQKLQAIQS*SRHQ SYRILEPWRHRETMSVRLPQSIDRLSSLSSLGD SAPERKSPSHHRQPSDASETTGLVQRCVIIQKD QHGFGFTVSGDRIVLVQSVRPGGAAMKAGVKEGD RIIKVNGTMVTNSSHLEVVKLIKSGAYVALTLL GSSPSSMGISGLQQDPSPAGAPRITSVIPSPPP PPPLPPPQRITGPKPLQDPEVQKHATQILRNMLR QEEKELQRICEVYSRNPASLLEEQIEGARRRVT QLQLKIQQETGGSVDILPLYGDTSQRPSEGRLS LDSQEGDSGLDSGTERFPSLSESLMNRNSVLSDP GLDSPRTSPVIMARVAQHHRRQGSDAAVPSTGD QGVDQSPKPLIIGPEEDYDPGYFNNESDIIFQD LEKLKSRPAHLGVFLRYIFSQADPSPLLFYLCAE VYQQASPKDSRSLGKDIWNIFLEKNAPLRVKIP EMLQAEIDSRLRNSEDARGVLCEAQEAAMPEIQ EQIHDYRTKRTLGLGSLYGENDLLDLDGDPLRER QVAEKQLAALGDILSKYEEDRSAPMDFALNTYM SHAGIRLREARPSNTAEKAQSAPDKDKWLPFFP KTKKSSNSKKEKDALEDKKRNPILKYIGKPKSSS QSTFHIPLSPVEVKPGNVRNIIQHFENNQQYDA PEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSE SLKGREEMKRSRKAENVPRSRSDVDMDAAAEATR LHQSASSSTSSLSTRSLENPTPPFTPKMGRRSI ESPSLGFCTDTLLPHLLEDDLGQLSDLEPEPDA QNWQHTVGKDVVAGLTQREIDRQEVINELFVTEA SHLRTLRVLDLIFYQRMKKENLMPREELARLFP NLPELIEIHNSWCEAMKKLREEGPIIKEISDLM LARFDGPAREELQQVAAQFCSYQSIALELIKTKQ RKESRFQLFMQEAESHPQCRRLQLRDLIISEMQ RLTKYPLLLESIIKHTEGGTSEHEKLCRARDQC REILKYVNEAVKQTENRHRLEGYQKRLDATALER ASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDK TLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAV GSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIIC TSKLGPPQIYELVALTSSDKNTWMELLEEAVRN ATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVE LDDSDVFHGEPEPEELPGGTGSQQRVQGKHQVLL EDPEQEGSAEEEELGVLPCPSTSLDGENRGIRT RNPIHLAFPGPLFMEGLADSALEDVENLRHLIL WSLLPGHTMETQAAQEPEDDLTPTPSVISVTSHP WDPGSPGQAPPGGEGDNTQLAGLEGERPEQEDM GLCSLEHLPPRTRNSGIWESPELDRNLAEDASS TEAAGGYKVVRKAEVAGSKVVPALPESGQSEPGP PEVEGGTKATGNCFYVSMPSGPPDSSTDHSEAP MSPPQPDSLPAGQTEPQPQLQGGNDDPRRPSRS PPSLALRDVGMIFHTIEQLTLKLNRLKDMELAHR ELLKSLGGESSGGTTPVGSFHTEAARWTDGSLS PPAKEPLASDSRNSHELGPCPEDGSDAPLEDST ADAAASPGP*PYKPPNPLRPHSSFRDWPETGAQG RGDPNTPPCGGGS*GN*DPAKARGETRMLLGLL KSESGFSVFSLP*PNPPRPHVS*AC*LHPKGPH SPWSALTPHMCVHAHACMCAALRHASERRRLLCK CTFFLPSFSIRPQAEVGASPPLFVTLVSYKYVC IVCASLLL*ITLTFFVPVPEVLEAVMEGAA*GR GVSLVSP*LTTQFQDRA*SGSQA*VFLSL*VGRS SGSPSHLAPEPALHSLLPSYSLPPWTSHLHKMG IMGVSYPTYVPLFPTLSL*KTSEAGTELRTGPQ EVGTGV*MPSP*IHPGPSKGPPQHWPHHHVLTQL SLMNRIYTLC*VYIYIYIYINIYIIYKI*IWK* LFCC*DNVYSFIFFLSWLRFFF*EKLNIL