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Sequences

Sequence NM_133642

GCGGCCGCGCTCGTCTCGCCGGGCTGTTCGCGGGCAGGCCCTGCCCTGAAGGGACGAATCGGCTTGGAGCGCGGGAGGTGGAGTCGGCCCCGGCGGTCGC TCCCTGGACCCAACCCGAGGCTGACCCAGGCCCCTGCCCATGCGGGGCGCCCCTGGCTCGGAAGAGTCCCCCGGGCCGGGAGCAGCTCCAGGCAGCGGCC CCGGAGGAAGAGGAAGAAGGGACAGTGCTCAGCTTGGGGGACCCGGACCCTCGCCGCGGCATTTGGAGCCGGGGGCAGTCCCGAACTCTGTGCTTGGCAC CGCCGCTCCGAGTAGGGCAGCGCCTGCCGGGACCCTGACCCGGACCCCCTGCGCCTCGTAGGCGGCGGCGCCGCCGCGCCACCCTGTTCTTCCGTGTCTC CCTCTGCCTGGCGGCAGTCACGGCCAAGAGAGTATTATGAGGGAGGCCGAGGACTTCATGCTCCGGACAGAGAAACGGCGCTGGGATTAGGGATTGCCAC TTCTGAGAGGATGCTGGGAATCTGCAGGGGGAGACGGAAATTCTTGGCTGCCTCGTTGAGTCTTCTCTGCATCCCAGCCATCACCTGGATTTACCTGTTT TCTGGGAGCTTCGAAGATGGAAAGCCCGTGTCTCTGTCACCGCTGGAGTCCCAGGCACACAGCCCCAGGTACACGGCCTCCAGCCAGCGGGAGCGCGAGA GCCTGGAGGTGCGCATGCGCGAGGTGGAGGAGGAGAACCGCGCCCTCCGCAGGCAGCTCAGCCTGGCCCAGGGCCGAGCCCCATCCCATCGCCGAGGCAA CCACTCCAAGACCTACTCCATGGAGGAGGGCACTGGAGACAGCGAGAACCTTCGGGCTGGCATCGTGGCAGGCAACAGCTCCGAGTGTGGGCAGCAGCCG GTCGTGGAGAAATGCGAGACAATCCACGTTGCTATTGTCTGCGCCGGATACAATGCCAGCCGGGATGTCGTCACCCTGGTCAAATCCGTCCTGTTCCATA GACGGAACCCTCTGCACTTCCACCTTATTGCTGACTCCATTGCGGAGCAGATCCTGGCCACGCTCTTCCAGACCTGGATGGTGCCCGCTGTGCGTGTGGA CTTCTACAATGCAGACGAGCTCAAGTCTGAAGTTTCCTGGATCCCCAATAAACATTACTCTGGGATTTATGGTCTGATGAAGCTTGTCCTGACCAAGACT CTTCCTGCCAACCTGGAGAGAGTCATCGTCCTTGACACGGATATCACCTTTGCCACTGACATTGCAGAGCTGTGGGCTGTGTTCCACAAGTTCAAAGGTC AGCAAGTCCTGGGCTTGGTGGAGAACCAGAGTGACTGGTACCTTGGAAACCTGTGGAAAAATCACCGCCCATGGCCAGCCCTTGGAAGAGGCTACAACAC AGGGGTGATCCTGTTACTTCTGGATAAGCTGCGGAAGATGAAATGGGAGCAGATGTGGAGGCTGACCGCAGAGAGGGAGCTCATGGGCATGCTCTCTACA TCCTTAGCTGACCAGGATATTTTCAATGCCGTCATCAAACAAAACCCCTTCCTTGTGTACCAGCTCCCCTGCTTCTGGAATGTGCAGCTGTCAGACCACA CCCGCTCCGAGCAGTGCTACAGAGACGTGTCTGATCTAAAGGTCATTCACTGGAACTCCCCCAAGAAGCTCCGGGTGAAGAACAAGCATGTGGAGTTTTT TCGCAACCTCTACCTGACCTTCCTGGAGTATGACGGCAATCTTCTGAGGCGGGAACTGTTTGGCTGCCCCAGTGAGGCTGATGTCAACAGTGAAAACCTC CAGAAGCAGCTGTCTGAGCTGGACGAGGACGACCTGTGCTATGAGTTCCGGCGAGAGCGCTTCACTGTCCACCGCACCCACCTGTACTTCCTGCACTACG AGTATGAGCCTGCAGCAGACAGCACGGACGTCACCCTGGTCGCTCAGCTGTCCATGGACAGGCTCCAGATGCTGGAGGCCATCTGCAAGCACTGGGAGGG GCCCATCAGCCTGGCCCTCTACCTGTCAGACGCCGAGGCCCAGCAGTTCCTCCGCTACGCACAGGGCTCTGAGGTGCTTATGAGCCGCCACAACGTGGGC TACCACATCGTGTACAAGGAGGGCCAGTTCTACCCCGTGAACCTGCTGCGCAACGTGGCCATGAAGCACATCAGCACTCCCTACATGTTCCTGTCTGACA TTGACTTCCTGCCCATGTATGGGCTCTATGAGTACCTCAGGAAGTCTGTCATCCAGCTCGATCTTGCCAACACCAAGAAAGCAATGATTGTCCCCGCGTT CGAGACACTGCGCTACCGGCTGTCCTTCCCCAAGTCAAAAGCGGAGTTGCTGTCAATGCTGGACATGGGGACCCTCTTCACATTCAGGTACCACGTCTGG ACGAAAGGCCACGCACCCACAAACTTCGCCAAGTGGCGGACCGCCACCACGCCTTACCGGGTTGAGTGGGAGGCCGATTTTGAGCCGTATGTTGTTGTGA GACGTGACTGCCCGGAGTACGACCGGAGGTTTGTAGGCTTTGGCTGGAACAAAGTGGCTCATATCATGGAGCTGGATGTGCAGGAGTATGAGTTCATTGT GCTGCCCAACGCCTACATGATCCACATGCCTCATGCCCCCAGCTTCGACATTACCAAGTTCCGTTCCAACAAGCAATACCGCATCTGTCTCAAAACCCTC AAGGAAGAGTTTCAGCAGGACATGTCCCGCCGCTACGGCTTTGCTGCCCTGAAATATCTCACAGCCGAGAACAACAGCTAGCACCAAGAAGCCCACCACT AGGGGGAGACATGCTGTAGGGGAAGTGCCACTCGCTGTTTGGGGCCCGGCCTTCAAATTCAAAATTGAGCCATGCTTTTTCGGTTTGTTTTTATTTATCT CTTTGGCCCAGCCAAGCTGCCCTCACTACAGAGACCTTGGACAAGGATCCAGCCAGTCCCTCTCTGCCCCACAACCCTGCATTCCCAGAGGTTAGCTATG CAGCCCACCTAGATGAGTCTCTTCAAGAATGGGAAATCAAGGGGTGACAGGGAGTAAAAGGGTTATCATCTTACTGCAAAGCCACAAGATCAGGGCAGGG CTTTAGGATGTTCTGGATGCTTTTTAATAATTATGCTTCCCATCATAACTGGGGAGAAAGGGAAGTCAGGGTTCTAGGGGTTATTCGTCCCAGGAAATAG AAGTGAAATTGTCTTTATTAAGTGAAAACTTTCCCCTTTGCCCTGCAATGTAGCTGGGCATTCAAACGGAGGGCAAACCGATGATCTAAACCAACCACTT GGAAAAACCCAATGGGGACATTGTAACCAGAGGGTCCTGGAGGTGGGGTTGATGGGTTTCCTTATCCCCAAAGTCACTCCTGTTTTGTTTTGTTTTTCTT TGGGGGTTTTGTTTATTTTTGGGGCTGGCAATCCAAAATAGAAAATCTGATCCTTTGAGGCTCTAAAGGAAAATCAGCTGCCTCTACCAACCACCCTCTA TCAGCAGTGGCCCAGGAAGGAGGTCAAGCATCTTCGGCCGATATTTAAACATGGGCAGCTTCCTTCAGGATGATCACCGAGGCTCCCGTGACTTTGAACT CCCTACTCTCCAGAATCCAGGGGCTATAGCGATGGGGACTGCGGAATTACGAGGGCTGGCTGTTTTACACCGGTCACATTTTCTATTGGCAGTGACTGAT TCATGGGAAAGGGCTTTGAAGGAACTACTTCAGTGCACACACAAGGTACGAACCTCTCAGGCCTTTCGAAGAACTTTCATAATTCATGAAAGCCCAGTTC TGAAGATTCACGTATCCATCTGGAGACCTACAGGAAGAAAGTGATTGGGTTCCTCTGGTTCTTGCCTGCTTCACTGTGGATGGGAAGAGGTGACAACCTC AGTCTCCCTTTGGGACCTGTCCAAGGGTAGGCAACCACCTTCACCTTCACACAGATTGAGGAGACACTGGACTTTTTACCCATTTTCTTTAATCTTCAAT ATTAATATTGTGTTTACATTGATGAGAACAAGAGTTAATGCCCTACCCTCTGCTGGGCTGTTTGTATTGAGTTGCAATGTGACCAGCGAAAGCTGCATTT AATAAATGAAAGTACAGACTGTTTCTTCCCC

refseq_LARGE.F1 (forward primer)
refseq_LARGE.R1 (reverse primer)
Single exon skipping

Frame 0

AAALVSPGCSRAGPALKGRIGLERGRWSRPRRS LPGPNPRLTQAPAHAGRPWLGRVPRAGSSSRQRP RRKRKKGQCSAWGTRTLAAAFGAGGSPELCAWH RRSE*GSACRDPDPDPLRLVGGGAAAPPCSSVS PSAWRQSRPREYYEGGRGLHAPDRETALGLGIAT SERMLGICRGRRKFLAASLSLLCIPAITWIYLF SGSFEDGKPVSLSPLESQAHSPRYTASSQRERE SLEVRMREVEEENRALRRQLSLAQGRAPSHRRGN HSKTYSMEEGTGDSENLRAGIVAGNSSECGQQP VVEKCETIHVAIVCAGYNASRDVVTLVKSVLFH RRNPLHFHLIADSIAEQILATLFQTWMVPAVRVD FYNADELKSEVSWIPNKHYSGIYGLMKLVLTKT LPANLERVIVLDTDITFATDIAELWAVFHKFKG QQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNT GVILLLLDKLRKMKWEQMWRLTAERELMGMLST SLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDH TRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFF RNLYLTFLEYDGNLLRRELFGCPSEADVNSENL QKQLSELDEDDLCYEFRRERFTVHRTHLYFLHY EYEPAADSTDVTLVAQLSMDRLQMLEAICKHWEG PISLALYLSDAEAQQFLRYAQGSEVLMSRHNVG YHIVYKEGQFYPVNLLRNVAMKHISTPYMFLSD IDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAF ETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVW TKGHAPTNFAKWRTATTPYRVEWEADFEPYVVV RRDCPEYDRRFVGFGWNKVAHIMELDVQEYEFIV LPNAYMIHMPHAPSFDITKFRSNKQYRICLKTL KEEFQQDMSRRYGFAALKYLTAENNS*HQEAHH *GETCCRGSATRCLGPGLQIQN*AMLFRFVFIYL FGPAKLPSLQRPWTRIQPVPLCPTTLHSQRLAM QPT*MSLFKNGKSRGDRE*KGYHLTAKPQDQGR ALGCSGCFLIIMLPIITGEKGKSGF*GLFVPGNR SEIVFIK*KLSPLPCNVAGHSNGGQTDDLNQPL GKTQWGHCNQRVLEVGLMGFLIPKVTPVLFCFS LGVLFIFGAGNPK*KI*SFEALKENQLPLPTTLY QQWPRKEVKHLRPIFKHGQLPSG*SPRLP*L*T PYSPESRGYSDGDCGITRAGCFTPVTFSIGSD* FMGKGFEGTTSVHTQGTNLSGLSKNFHNS*KPSS EDSRIHLETYRKKVIGFLWFLPASLWMGRGDNL SLPLGPVQG*ATTFTFTQIEETLDFLPIFFNLQ Y*YCVYIDENKS*CPTLCWAVCIELQCDQRKLHL INESTDCFFP

Frame 1

RPRSSRRAVRGQALP*RDESAWSAGGGVGPGGR SLDPTRG*PRPLPMRGAPGSEESPGPGAAPGSG PGGRGRRDSAQLGGPGPSPRHLEPGAVPNSVLGT AAPSRAAPAGTLTRTPCAS*AAAPPRHPVLPCL PLPGGSHGQESIMREAEDFMLRTEKRRWD*GLP LLRGCWESAGGDGNSWLPR*VFSASQPSPGFTCF LGASKMESPCLCHRWSPRHTAPGTRPPASGSAR AWRCACARWRRRTAPSAGSSAWPRAEPHPIAEA TTPRPTPWRRALETARTFGLASWQATAPSVGSSR SWRNARQSTLLLSAPDTMPAGMSSPWSNPSCSI DGTLCTSTLLLTPLRSRSWPRSSRPGWCPLCVW TSTMQTSSSLKFPGSPINITLGFMV**SLS*PRL FLPTWRESSSLTRISPLPLTLQSCGLCSTSSKV SKSWAWWRTRVTGTLETCGKITAHGQPLEEATT QG*SCYFWISCGR*NGSRCGG*PQRGSSWACSLH P*LTRIFSMPSSNKTPSLCTSSPASGMCSCQTT PAPSSATETCLI*RSFTGTPPRSSG*RTSMWSF FATST*PSWSMTAIF*GGNCLAAPVRLMSTVKTS RSSCLSWTRTTCAMSSGESASLSTAPTCTSCTT SMSLQQTARTSPWSLSCPWTGSRCWRPSASTGR GPSAWPSTCQTPRPSSSSATHRALRCL*AATTWA TTSCTRRASSTP*TCCATWP*STSALPTCSCLT LTSCPCMGSMSTSGSLSSSSILPTPRKQ*LSPR SRHCATGCPSPSQKRSCCQCWTWGPSSHSGTTSG RKATHPQTSPSGGPPPRLTGLSGRPILSRMLL* DVTARSTTGGL*ALAGTKWLISWSWMCRSMSSL CCPTPT*STCLMPPASTLPSSVPTSNTASVSKPS RKSFSRTCPAATALLP*NISQPRTTASTKKPTT RGRHAVGEVPLAVWGPAFKFKIEPCFFGLFLFI SLAQPSCPHYRDLGQGSSQSLSAPQPCIPRG*LC SPPR*VSSRMGNQGVTGSKRVIILLQSHKIRAG L*DVLDAF**LCFPS*LGRKGSQGSRGYSSQEI EVKLSLLSENFPLCPAM*LGIQTEGKPMI*TNHL EKPNGDIVTRGSWRWG*WVSLSPKSLLFCFVFL WGFCLFLGLAIQNRKSDPLRL*RKISCLYQPPS ISSGPGRRSSIFGRYLNMGSFLQDDHRGSRDFEL PTLQNPGAIAMGTAELRGLAVLHRSHFLLAVTD SWERALKELLQCTHKVRTSQAFRRTFIIHESPV LKIHVSIWRPTGRK*LGSSGSCLLHCGWEEVTTS VSLWDLSKGRQPPSPSHRLRRHWTFYPFSLIFN INIVFTLMRTRVNALPSAGLFVLSCNVTSESCI **MKVQTVSS

Frame 2

GRARLAGLFAGRPCPEGTNRLGAREVESAPAVA PWTQPEADPGPCPCGAPLARKSPPGREQLQAAA PEEEEEGTVLSLGDPDPRRGIWSRGQSRTLCLA PPLRVGQRLPGP*PGPPAPRRRRRRRATLFFRVS LCLAAVTAKRVL*GRPRTSCSGQRNGAGIRDCH F*EDAGNLQGETEILGCLVESSLHPSHHLDLPV FWELRRWKARVSVTAGVPGTQPQVHGLQPAGARE PGGAHARGGGGEPRPPQAAQPGPGPSPIPSPRQ PLQDLLHGGGHWRQREPSGWHRGRQQLRVWAAA GRGEMRDNPRCYCLRRIQCQPGCRHPGQIRPVP* TEPSALPPYC*LHCGADPGHALPDLDGARCACG LLQCRRAQV*SFLDPQ*TLLWDLWSDEACPDQD SSCQPGESHRP*HGYHLCH*HCRAVGCVPQVQRS ASPGLGGEPE*LVPWKPVEKSPPMASPWKRLQH RGDPVTSG*AAEDEMGADVEADRREGAHGHALY ILS*PGYFQCRHQTKPLPCVPAPLLLECAAVRPH PLRAVLQRRV*SKGHSLELPQEAPGEEQACGVF SQPLPDLPGV*RQSSEAGTVWLPQ*G*CQQ*KP PEAAV*AGRGRPVL*VPARALHCPPHPPVLPALR V*ACSRQHGRHPGRSAVHGQAPDAGGHLQALGG AHQPGPLPVRRRGPAVPPLRTGL*GAYEPPQRG LPHRVQGGPVLPREPAAQRGHEAHQHSLHVPV*H *LPAHVWAL*VPQEVCHPARSCQHQESNDCPRV RDTALPAVLPQVKSGVAVNAGHGDPLHIQVPRL DERPRTHKLRQVADRHHALPG*VGGRF*AVCCCE T*LPGVRPEVCRLWLEQSGSYHGAGCAGV*VHC AAQRLHDPHASCPQLRHYQVPFQQAIPHLSQNP QGRVSAGHVPPLRLCCPEISHSREQQLAPRSPPL GGDML*GKCHSLFGARPSNSKLSHAFSVCFYLS LWPSQAALTTETLDKDPASPSLPHNPAFPEVSY AAHLDESLQEWEIKG*QGVKGLSSYCKATRSGQG FRMFWMLFNNYASHHNWGEREVRVLGVIRPRK* K*NCLY*VKTFPFALQCSWAFKRRANR*SKPTT WKNPMGTL*PEGPGGGVDGFPYPQSHSCFVLFFF GGFVYFWGWQSKIENLIL*GSKGKSAASTNHPL SAVAQEGGQASSADI*TWAASFRMITEAPVTLN SLLSRIQGL*RWGLRNYEGWLFYTGHIFYWQ*LI HGKGL*RNYFSAHTRYEPLRPFEELS*FMKAQF *RFTYPSGDLQEESDWVPLVLACFTVDGKR*QP QSPFGTCPRVGNHLHLHTD*GDTGLFTHFL*SSI LILCLH**EQELMPYPLLGCLY*VAM*PAKAAF NK*KYRLFLP

Sequence NM_004737

GCGGCCGCGCTCGTCTCGCCGGGCTGTTCGCGGGCAGGCCCTGCCCTGAAGGGACGAATCGGCTTGGAGCGCGGGAGGTGGAGTCGGCCCCGGCGGTCGC TCCCTGGACCCAACCCGAGGCTGACCCAGGCCCCTGCCCATGCGGGGCGCCCCTGGCTCGGAAGAGTCCCCCGGGCCGGGAGCAGCTCCAGGCAGCGGCC CCGGAGGAAGAGGAAGAAGGGACAGTGCTCAGCTTGGGGGACCCGGACCCTCGCCGCGGCATTTGGAGCCGGGGGCAGTCCCGAACTCTGTGCTTGGCAC CGCCGCTCCGAGTAGGGCAGCGCCTGCCGGGACCCTGACCCGGACCCCCTGCGCCTCGTAGGCGGCGGCGCCGCCGCGCCACCCTGTTCTTCCGTGTCTC CCTCTGCCTGGCGGCAGTCACGGCCAAGAACCTACATTAAGAAACGCATTCAGATGCATCAGCCGTTTGTAAAGCACCTGTCGTGAGCCAGAGAGTATTA TGAGGGAGGCCGAGGACTTCATGCTCCGGACAGAGAAACGGCGCTGGGATTAGGGATTGCCACTTCTGAGAGGATGCTGGGAATCTGCAGGGGGAGACGG AAATTCTTGGCTGCCTCGTTGAGTCTTCTCTGCATCCCAGCCATCACCTGGATTTACCTGTTTTCTGGGAGCTTCGAAGATGGAAAGCCCGTGTCTCTGT CACCGCTGGAGTCCCAGGCACACAGCCCCAGGTACACGGCCTCCAGCCAGCGGGAGCGCGAGAGCCTGGAGGTGCGCATGCGCGAGGTGGAGGAGGAGAA CCGCGCCCTCCGCAGGCAGCTCAGCCTGGCCCAGGGCCGAGCCCCATCCCATCGCCGAGGCAACCACTCCAAGACCTACTCCATGGAGGAGGGCACTGGA GACAGCGAGAACCTTCGGGCTGGCATCGTGGCAGGCAACAGCTCCGAGTGTGGGCAGCAGCCGGTCGTGGAGAAATGCGAGACAATCCACGTTGCTATTG TCTGCGCCGGATACAATGCCAGCCGGGATGTCGTCACCCTGGTCAAATCCGTCCTGTTCCATAGACGGAACCCTCTGCACTTCCACCTTATTGCTGACTC CATTGCGGAGCAGATCCTGGCCACGCTCTTCCAGACCTGGATGGTGCCCGCTGTGCGTGTGGACTTCTACAATGCAGACGAGCTCAAGTCTGAAGTTTCC TGGATCCCCAATAAACATTACTCTGGGATTTATGGTCTGATGAAGCTTGTCCTGACCAAGACTCTTCCTGCCAACCTGGAGAGAGTCATCGTCCTTGACA CGGATATCACCTTTGCCACTGACATTGCAGAGCTGTGGGCTGTGTTCCACAAGTTCAAAGGTCAGCAAGTCCTGGGCTTGGTGGAGAACCAGAGTGACTG GTACCTTGGAAACCTGTGGAAAAATCACCGCCCATGGCCAGCCCTTGGAAGAGGCTACAACACAGGGGTGATCCTGTTACTTCTGGATAAGCTGCGGAAG ATGAAATGGGAGCAGATGTGGAGGCTGACCGCAGAGAGGGAGCTCATGGGCATGCTCTCTACATCCTTAGCTGACCAGGATATTTTCAATGCCGTCATCA AACAAAACCCCTTCCTTGTGTACCAGCTCCCCTGCTTCTGGAATGTGCAGCTGTCAGACCACACCCGCTCCGAGCAGTGCTACAGAGACGTGTCTGATCT AAAGGTCATTCACTGGAACTCCCCCAAGAAGCTCCGGGTGAAGAACAAGCATGTGGAGTTTTTTCGCAACCTCTACCTGACCTTCCTGGAGTATGACGGC AATCTTCTGAGGCGGGAACTGTTTGGCTGCCCCAGTGAGGCTGATGTCAACAGTGAAAACCTCCAGAAGCAGCTGTCTGAGCTGGACGAGGACGACCTGT GCTATGAGTTCCGGCGAGAGCGCTTCACTGTCCACCGCACCCACCTGTACTTCCTGCACTACGAGTATGAGCCTGCAGCAGACAGCACGGACGTCACCCT GGTCGCTCAGCTGTCCATGGACAGGCTCCAGATGCTGGAGGCCATCTGCAAGCACTGGGAGGGGCCCATCAGCCTGGCCCTCTACCTGTCAGACGCCGAG GCCCAGCAGTTCCTCCGCTACGCACAGGGCTCTGAGGTGCTTATGAGCCGCCACAACGTGGGCTACCACATCGTGTACAAGGAGGGCCAGTTCTACCCCG TGAACCTGCTGCGCAACGTGGCCATGAAGCACATCAGCACTCCCTACATGTTCCTGTCTGACATTGACTTCCTGCCCATGTATGGGCTCTATGAGTACCT CAGGAAGTCTGTCATCCAGCTCGATCTTGCCAACACCAAGAAAGCAATGATTGTCCCCGCGTTCGAGACACTGCGCTACCGGCTGTCCTTCCCCAAGTCA AAAGCGGAGTTGCTGTCAATGCTGGACATGGGGACCCTCTTCACATTCAGGTACCACGTCTGGACGAAAGGCCACGCACCCACAAACTTCGCCAAGTGGC GGACCGCCACCACGCCTTACCGGGTTGAGTGGGAGGCCGATTTTGAGCCGTATGTTGTTGTGAGACGTGACTGCCCGGAGTACGACCGGAGGTTTGTAGG CTTTGGCTGGAACAAAGTGGCTCATATCATGGAGCTGGATGTGCAGGAGTATGAGTTCATTGTGCTGCCCAACGCCTACATGATCCACATGCCTCATGCC CCCAGCTTCGACATTACCAAGTTCCGTTCCAACAAGCAATACCGCATCTGTCTCAAAACCCTCAAGGAAGAGTTTCAGCAGGACATGTCCCGCCGCTACG GCTTTGCTGCCCTGAAATATCTCACAGCCGAGAACAACAGCTAGCACCAAGAAGCCCACCACTAGGGGGAGACATGCTGTAGGGGAAGTGCCACTCGCTG TTTGGGGCCCGGCCTTCAAATTCAAAATTGAGCCATGCTTTTTCGGTTTGTTTTTATTTATCTCTTTGGCCCAGCCAAGCTGCCCTCACTACAGAGACCT TGGACAAGGATCCAGCCAGTCCCTCTCTGCCCCACAACCCTGCATTCCCAGAGGTTAGCTATGCAGCCCACCTAGATGAGTCTCTTCAAGAATGGGAAAT CAAGGGGTGACAGGGAGTAAAAGGGTTATCATCTTACTGCAAAGCCACAAGATCAGGGCAGGGCTTTAGGATGTTCTGGATGCTTTTTAATAATTATGCT TCCCATCATAACTGGGGAGAAAGGGAAGTCAGGGTTCTAGGGGTTATTCGTCCCAGGAAATAGAAGTGAAATTGTCTTTATTAAGTGAAAACTTTCCCCT TTGCCCTGCAATGTAGCTGGGCATTCAAACGGAGGGCAAACCGATGATCTAAACCAACCACTTGGAAAAACCCAATGGGGACATTGTAACCAGAGGGTCC TGGAGGTGGGGTTGATGGGTTTCCTTATCCCCAAAGTCACTCCTGTTTTGTTTTGTTTTTCTTTGGGGGTTTTGTTTATTTTTGGGGCTGGCAATCCAAA ATAGAAAATCTGATCCTTTGAGGCTCTAAAGGAAAATCAGCTGCCTCTACCAACCACCCTCTATCAGCAGTGGCCCAGGAAGGAGGTCAAGCATCTTCGG CCGATATTTAAACATGGGCAGCTTCCTTCAGGATGATCACCGAGGCTCCCGTGACTTTGAACTCCCTACTCTCCAGAATCCAGGGGCTATAGCGATGGGG ACTGCGGAATTACGAGGGCTGGCTGTTTTACACCGGTCACATTTTCTATTGGCAGTGACTGATTCATGGGAAAGGGCTTTGAAGGAACTACTTCAGTGCA CACACAAGGTACGAACCTCTCAGGCCTTTCGAAGAACTTTCATAATTCATGAAAGCCCAGTTCTGAAGATTCACGTATCCATCTGGAGACCTACAGGAAG AAAGTGATTGGGTTCCTCTGGTTCTTGCCTGCTTCACTGTGGATGGGAAGAGGTGACAACCTCAGTCTCCCTTTGGGACCTGTCCAAGGGTAGGCAACCA CCTTCACCTTCACACAGATTGAGGAGACACTGGACTTTTTACCCATTTTCTTTAATCTTCAATATTAATATTGTGTTTACATTGATGAGAACAAGAGTTA ATGCCCTACCCTCTGCTGGGCTGTTTGTATTGAGTTGCAATGTGACCAGCGAAAGCTGCATTTAATAAATGAAAGTACAGACTGTTTCTTCCCC

refseq_LARGE.F1 (forward primer)
refseq_LARGE.R1 (reverse primer)
Single exon skipping

Frame 0

AAALVSPGCSRAGPALKGRIGLERGRWSRPRRS LPGPNPRLTQAPAHAGRPWLGRVPRAGSSSRQRP RRKRKKGQCSAWGTRTLAAAFGAGGSPELCAWH RRSE*GSACRDPDPDPLRLVGGGAAAPPCSSVS PSAWRQSRPRTYIKKRIQMHQPFVKHLS*AREYY EGGRGLHAPDRETALGLGIATSERMLGICRGRR KFLAASLSLLCIPAITWIYLFSGSFEDGKPVSL SPLESQAHSPRYTASSQRERESLEVRMREVEEEN RALRRQLSLAQGRAPSHRRGNHSKTYSMEEGTG DSENLRAGIVAGNSSECGQQPVVEKCETIHVAI VCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADS IAEQILATLFQTWMVPAVRVDFYNADELKSEVS WIPNKHYSGIYGLMKLVLTKTLPANLERVIVLD TDITFATDIAELWAVFHKFKGQQVLGLVENQSDW YLGNLWKNHRPWPALGRGYNTGVILLLLDKLRK MKWEQMWRLTAERELMGMLSTSLADQDIFNAVI KQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDL KVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDG NLLRRELFGCPSEADVNSENLQKQLSELDEDDL CYEFRRERFTVHRTHLYFLHYEYEPAADSTDVTL VAQLSMDRLQMLEAICKHWEGPISLALYLSDAE AQQFLRYAQGSEVLMSRHNVGYHIVYKEGQFYP VNLLRNVAMKHISTPYMFLSDIDFLPMYGLYEYL RKSVIQLDLANTKKAMIVPAFETLRYRLSFPKS KAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKW RTATTPYRVEWEADFEPYVVVRRDCPEYDRRFVG FGWNKVAHIMELDVQEYEFIVLPNAYMIHMPHA PSFDITKFRSNKQYRICLKTLKEEFQQDMSRRY GFAALKYLTAENNS*HQEAHH*GETCCRGSATRC LGPGLQIQN*AMLFRFVFIYLFGPAKLPSLQRP WTRIQPVPLCPTTLHSQRLAMQPT*MSLFKNGK SRGDRE*KGYHLTAKPQDQGRALGCSGCFLIIML PIITGEKGKSGF*GLFVPGNRSEIVFIK*KLSP LPCNVAGHSNGGQTDDLNQPLGKTQWGHCNQRV LEVGLMGFLIPKVTPVLFCFSLGVLFIFGAGNPK *KI*SFEALKENQLPLPTTLYQQWPRKEVKHLR PIFKHGQLPSG*SPRLP*L*TPYSPESRGYSDG DCGITRAGCFTPVTFSIGSD*FMGKGFEGTTSVH TQGTNLSGLSKNFHNS*KPSSEDSRIHLETYRK KVIGFLWFLPASLWMGRGDNLSLPLGPVQG*AT TFTFTQIEETLDFLPIFFNLQY*YCVYIDENKS* CPTLCWAVCIELQCDQRKLHLINESTDCFFP

Frame 1

RPRSSRRAVRGQALP*RDESAWSAGGGVGPGGR SLDPTRG*PRPLPMRGAPGSEESPGPGAAPGSG PGGRGRRDSAQLGGPGPSPRHLEPGAVPNSVLGT AAPSRAAPAGTLTRTPCAS*AAAPPRHPVLPCL PLPGGSHGQEPTLRNAFRCISRL*STCREPESI MREAEDFMLRTEKRRWD*GLPLLRGCWESAGGDG NSWLPR*VFSASQPSPGFTCFLGASKMESPCLC HRWSPRHTAPGTRPPASGSARAWRCACARWRRR TAPSAGSSAWPRAEPHPIAEATTPRPTPWRRALE TARTFGLASWQATAPSVGSSRSWRNARQSTLLL SAPDTMPAGMSSPWSNPSCSIDGTLCTSTLLLT PLRSRSWPRSSRPGWCPLCVWTSTMQTSSSLKFP GSPINITLGFMV**SLS*PRLFLPTWRESSSLT RISPLPLTLQSCGLCSTSSKVSKSWAWWRTRVT GTLETCGKITAHGQPLEEATTQG*SCYFWISCGR *NGSRCGG*PQRGSSWACSLHP*LTRIFSMPSS NKTPSLCTSSPASGMCSCQTTPAPSSATETCLI *RSFTGTPPRSSG*RTSMWSFFATST*PSWSMTA IF*GGNCLAAPVRLMSTVKTSRSSCLSWTRTTC AMSSGESASLSTAPTCTSCTTSMSLQQTARTSP WSLSCPWTGSRCWRPSASTGRGPSAWPSTCQTPR PSSSSATHRALRCL*AATTWATTSCTRRASSTP *TCCATWP*STSALPTCSCLTLTSCPCMGSMST SGSLSSSSILPTPRKQ*LSPRSRHCATGCPSPSQ KRSCCQCWTWGPSSHSGTTSGRKATHPQTSPSG GPPPRLTGLSGRPILSRMLL*DVTARSTTGGL* ALAGTKWLISWSWMCRSMSSLCCPTPT*STCLMP PASTLPSSVPTSNTASVSKPSRKSFSRTCPAAT ALLP*NISQPRTTASTKKPTTRGRHAVGEVPLA VWGPAFKFKIEPCFFGLFLFISLAQPSCPHYRDL GQGSSQSLSAPQPCIPRG*LCSPPR*VSSRMGN QGVTGSKRVIILLQSHKIRAGL*DVLDAF**LC FPS*LGRKGSQGSRGYSSQEIEVKLSLLSENFPL CPAM*LGIQTEGKPMI*TNHLEKPNGDIVTRGS WRWG*WVSLSPKSLLFCFVFLWGFCLFLGLAIQ NRKSDPLRL*RKISCLYQPPSISSGPGRRSSIFG RYLNMGSFLQDDHRGSRDFELPTLQNPGAIAMG TAELRGLAVLHRSHFLLAVTDSWERALKELLQC THKVRTSQAFRRTFIIHESPVLKIHVSIWRPTGR K*LGSSGSCLLHCGWEEVTTSVSLWDLSKGRQP PSPSHRLRRHWTFYPFSLIFNINIVFTLMRTRV NALPSAGLFVLSCNVTSESCI**MKVQTVSS

Frame 2

GRARLAGLFAGRPCPEGTNRLGAREVESAPAVA PWTQPEADPGPCPCGAPLARKSPPGREQLQAAA PEEEEEGTVLSLGDPDPRRGIWSRGQSRTLCLA PPLRVGQRLPGP*PGPPAPRRRRRRRATLFFRVS LCLAAVTAKNLH*ETHSDASAVCKAPVVSQRVL *GRPRTSCSGQRNGAGIRDCHF*EDAGNLQGET EILGCLVESSLHPSHHLDLPVFWELRRWKARVSV TAGVPGTQPQVHGLQPAGAREPGGAHARGGGGE PRPPQAAQPGPGPSPIPSPRQPLQDLLHGGGHW RQREPSGWHRGRQQLRVWAAAGRGEMRDNPRCYC LRRIQCQPGCRHPGQIRPVP*TEPSALPPYC*L HCGADPGHALPDLDGARCACGLLQCRRAQV*SF LDPQ*TLLWDLWSDEACPDQDSSCQPGESHRP*H GYHLCH*HCRAVGCVPQVQRSASPGLGGEPE*L VPWKPVEKSPPMASPWKRLQHRGDPVTSG*AAE DEMGADVEADRREGAHGHALYILS*PGYFQCRHQ TKPLPCVPAPLLLECAAVRPHPLRAVLQRRV*S KGHSLELPQEAPGEEQACGVFSQPLPDLPGV*R QSSEAGTVWLPQ*G*CQQ*KPPEAAV*AGRGRPV L*VPARALHCPPHPPVLPALRV*ACSRQHGRHP GRSAVHGQAPDAGGHLQALGGAHQPGPLPVRRR GPAVPPLRTGL*GAYEPPQRGLPHRVQGGPVLPR EPAAQRGHEAHQHSLHVPV*H*LPAHVWAL*VP QEVCHPARSCQHQESNDCPRVRDTALPAVLPQV KSGVAVNAGHGDPLHIQVPRLDERPRTHKLRQVA DRHHALPG*VGGRF*AVCCCET*LPGVRPEVCR LWLEQSGSYHGAGCAGV*VHCAAQRLHDPHASC PQLRHYQVPFQQAIPHLSQNPQGRVSAGHVPPLR LCCPEISHSREQQLAPRSPPLGGDML*GKCHSL FGARPSNSKLSHAFSVCFYLSLWPSQAALTTET LDKDPASPSLPHNPAFPEVSYAAHLDESLQEWEI KG*QGVKGLSSYCKATRSGQGFRMFWMLFNNYA SHHNWGEREVRVLGVIRPRK*K*NCLY*VKTFP FALQCSWAFKRRANR*SKPTTWKNPMGTL*PEGP GGGVDGFPYPQSHSCFVLFFFGGFVYFWGWQSK IENLIL*GSKGKSAASTNHPLSAVAQEGGQASS ADI*TWAASFRMITEAPVTLNSLLSRIQGL*RWG LRNYEGWLFYTGHIFYWQ*LIHGKGL*RNYFSA HTRYEPLRPFEELS*FMKAQF*RFTYPSGDLQE ESDWVPLVLACFTVDGKR*QPQSPFGTCPRVGNH LHLHTD*GDTGLFTHFL*SSILILCLH**EQEL MPYPLLGCLY*VAM*PAKAAFNK*KYRLFLP