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Sequences

Sequence NM_005385

GTGGCATTGGGAGGCCCGGCCTGGGGGAGGAGACGGCGTTCCGTTAGCGGCGTTGGGGTTTGGCTGCAGTGGCAGTGCTTTCTCTTCTGCTCACGGGGAC
CCGCTCAGGCTGGAGGCCAGCCAGCTCTTGCCGCCACCTCGGTCGCGATGGGGGCGCAGGACCGGCCGCAGTGCCACTTCGACATCGAGATCAACCGGGA
GCCGGTTGGTCGCATTATGTTTCAGCTCTTCTCAGACATATGTCCAAAAACATGCAAAAACTTCCTTTGCTTGTGCTCAGGAGAGAAAGGCCTTGGGAAA
ACAACTGGGAAGAAGTTATGTTATAAAGGTTCTACGTTCCATCGTGTGGTTAAAAACTTTATGATTCAGGGTGGGGACTTCAGTGAAGGTAATGGAAAAG
GTGGAGAATCAATTTATGGTGGATATTTTAAAGATGAAAACTTTATTCTCAAACATGACAGAGCGTTCCTTTTATCAATGGCAAATCGAGGGAAACATAC
CAATGGTTCCCAGTTTTTCATTACCACAAAGCCTGCTCCACACCTGGATGGGGTGCATGTAGTCTTTGGACTGGTTATTTCTGGTTTTGAAGTAATCGAA
CAAATTGAAAATCTGAAGACCGATGCTGCAAGCAGACCATATGCAGATGTGCGAGTTATTGACTGTGGAGTACTTGCCACAAAATCAATAAAAGATGTTT
TTGAGAAAAAAAGGAAGAAACCAACTCATTCAGAAGGCTCGGATTCCTCTTCCAATTCCTCCTCTTCTTCAGAATCATCTTCAGAAAGTGAACTTGAACA
TGAGAGAAGCAGAAGGAGGAAACATAAGAGGAGGCCAAAAGTTAAACGTTCTAAAAAGAGGCGAAAGGAAGCAAGCAGTTCAGAAGAGCCAAGGAATAAA
CATGCAATGAACCCAAAAGGTCACTCTGAGAGGAGTGATACCAATGAAAAAAGGTCAGTTGATTCCAGTGCTAAAAGGGAAAAACCTGTGGTCCGCCCAG
AAGAGATTCCTCCAGTGCCTGAGAACCGATTTTTACTGAGAAGAGATATGCCTGTTGTTACTGCAGAACCTGAACCGAAGATTCCTGATGTTGCACCCAT
TGTAAGTGATCAGAAACCATCTGTATCAAAGTCTGGACGGAAGATTAAAGGAAGGGGCACAATTCGCTATCACACACCTCCAAGATCAAGATCCTGTTCT
GAGTCAGATGATGATGACAGCAGTGAAACTCCTCCTCACTGGAAAGAGGAAATGCAGAGATTAAGAGCATATAGACCACCTAGTGGAGAAAAATGGAGTA
AAGGAGATAAGTTAAGTGACCCCTGTTCAAGCCGATGGGATGAAAGAAGCTTGTCTCAGAGATCCAGATCATGGTCCTATAATGGATATTATTCAGACCT
TAGTACAGCAAGACACTCTGGCCACCATAAAAAACGCAGAAAAGAAAAAAAGGTTAAGCATAAAAAGAAAGGGAAAAAGCAGAAACACTGCAGAAGACAC
AAACAAACAAAGAAGAGAAGGATTCTTATACCGTCTGACATAGAATCCTCAAAATCTTCCACTCGAAGAATGAAATCCTCTTGTGATAGAGAAAGGAGTT
CTCGTTCTTCCTCATTGTCATCTCATCACTCATCAAAGAGAGACTGGTCTAAATCTGATAAGGATGTCCAGAGCTCTTTAACCCATTCCAGCAGAGACTC
ATACAGATCAAAATCTCACTCACAGTCTTATTCTAGAGGAAGCTCAAGATCAAGGACTGCGTCAAAGTCCTCATCACATTCTCGAAGTAGATCAAAGTCC
AGATCTAGTTCCAAGTCTGGGCACCGAAAGAGAGCATCAAAATCACCAAGAAAAACAGCTTCTCAGTTAAGTGAAAATAAACCAGTTAAAACAGAACCTT
TAAGAGCAACCATGGCACAAAATGAAAATGTAGTAGTACAACCAGTTGTAGCAGAAAATATTCCTGTAATACCACTGAGTGACAGTCCCCCCCCTTCAAG
ATGGAAGCCTGGACAGAAACCTTGGAAGCCCTCTTATGAGCGAATTCAGGAAATGAAAGCTAAAACAACCCATTTGCTACCCATCCAAAGCACTTACAGT
TTAGCAAATATTAAAGAGACTGGTAGCTCATCATCCTACCATAAAAGAGAAAAAAATTCGGAAAGTGATCAGAGCACTTATTCAAAATACAGTGATAGAA
GTTCAGAAAGCTCACCAAGGTCAAGGAGCAGATCTTCTAGGAGTAGATCTTATTCCAGATCATATACAAGATCACGTAGTCTAGCTAGTTCACATTCAAG
GTCTAGGTCTCCATCATCTAGATCTCATTCACGAAATAAATACAGTGATCATTCACAGTGTAGTAGATCATCTTCATATACTTCTATTAGCAGTGATGAT
GGAAGGCGAGCTAAGAGGAGACTTAGATCCAGTGGGAAAAAAAATAGCGTTTCACATAAAAAGCATAGCAGCAGCTCTGAAAAGACACTTCACAGTAAAT
ATGTCAAAGGTAGAGACAGGTCTTCATGTGTGAGAAAGTATAGCGAGAGCAGATCATCTTTAGATTATTCTTCAGACAGTGAGCAGTCAAGTGTTCAGGC
CACACAGTCAGCCCAGGAAAAAGAGAAGCAGGGCCAAATGGAAAGAACACATAATAAACAAGAAAAAAACAGAGGTGAAGAAAAATCCAAGTCTGAACGG
GAATGCCCTCATTCAAAAAAAAGAACTTTGAAAGAGAATCTTTCTGATCACCTTAGAAATGGCAGTAAGCCCAAAAGGAAGAATTATGCTGGTAGTAAAT
GGGACTCTGAGTCAAATTCAGAACGAGATGTCACTAAAAACAGTAAAAATGACTCCCATCCATCCTCTGACAAGGAAGAAGGTGAGGCCACATCCGATTC
TGAATCAGAGGTTAGTGAAATTCACATCAAAGTCAAACCCACAACCAAGTCGTCCACAAATACTTCACTGCCTGATGATAATGGTGCTTGGAAATCAAGC
AAACAGCGCACATCAACTTCTGACTCTGAGGGGTCCTGTTCCAATTCGGAAAACAATAGGGGAAAGCCACAAAAGCACAAACATGGGTCAAAGGAAAATC
TTAAAAGAGAACACACCAAAAAAGTGAAAGAGAAATTGAAAGGGAAAAAAGACAAAAAGCATAAGGCTCCAAAACGAAAGCAAGCATTTCACTGGCAGCC
TCCACTAGAATTTGGTGAAGAGGAGGAGGAGGAGATTGATGACAAGCAAGTTACTCAGGAATCAAAAGAGAAAAAAGTTTCTGAAAACAATGAAACCATA
AAAGATAATATTCTAAAAACTGAGAAATCCAGTGAAGAGGACCTTTCAGGTAAACATGATACAGTGACTGTTTCATCAGATCTTGATCAGTTTACTAAAG
ATGATAGTAAACTCAGTATTTCTCCCACAGCTTTAAATACTGAGGAAAATGTGGCCTGTTTACAAAACATTCAGCACGTTGAAGAAAGTGTTCCCAATGG
AGTGGAAGATGTGCTTCAAACAGATGACAACATGGAGATCTGCACTCCTGATAGGAGTTCCCCAGCAAAAGTAGAGGAGACTTCCCCTCTAGGAAATGCA
CGGCTTGATACCCCAGATATAAACATTGTTTTGAAGCAGGATATGGCAACGGAACATCCTCAAGCAGAGGTAGTAAAACAGGAAAGCAGCATGTCCGAAA
GTAAAGTGTTGGGTGAAGTGGGGAAACAGGACAGCAGCTCTGCTAGCTTGGCTAGTGCTGGAGAAAGTACCGGGAAGAAGGAGGTGGCTGAGAAGAGCCA
GATCAACCTCATTGATAAGAAATGGAAGCCCCTGCAAGGTGTGGGGAACCTGGCAGCACCTAATGCTGCCACATCCAGTGCTGTGGAAGTTAAGGTGTTG
ACCACTGTGCCTGAAATGAAACCACAAGGCTTGAGAATAGAAATTAAAAGCAAAAATAAAGTTCGGCCTGGGTCTCTCTTTGATGAAGTAAGAAAGACAG
CACGCTTAAACCGTAGACCAAGAAATCAGGAGAGTTCAAGTGATGAGCAGACGCCTAGTCGGGATGATGATAGCCAGTCCAGGAGTCCAAGTAGATCTCG
AAGTAAATCTGAAACCAAATCAAGACACAGAACAAGGTCTGTCTCCTATAGTCACTCAAGAAGTCGATCGAGAAGTTCCACATCATCTTATCGATCAAGA
AGCTACTCTAGAAGTCGGAGCAGAGGATGGTACAGCAGAGGCCGAACCAGAAGCCGGAGCAGTTCCTACCGGAGTTACAAAAGTCACAGGACGTCCAGCA
GGAGCAGATCCAGGAGCAGCTCATATGATCCCCACAGTCGATCCAGGTCCTACACCTACGATAGCTACTATAGCAGGAGTCGGAGTCGAAGTAGAAGCCA
GAGAAGTGACAGTTACCACCGAGGCAGAAGTTATAATCGGCGGTCCAGGAGTTGTAGATCTTATGGCTCTGACAGTGAAAGTGACCGAAGTTACTCTCAT
CACCGGAGCCCCAGTGAGAGCAGCAGATACAGTTGAAAACGTCCGGATACAAATTATATCTTATTTGTAAATATCTGGCAACTTAGCTTAAGAAATGTAA
TGACAGTCTGTTGTTCTATTTCAATATCAGAGGTGAATTTCAAAAATAGACACTTCTTAATTGTTACTGGTTCATTTACATGTGGGGAGAAGAATTTAAA
ATACAGATATGTCTCCTAAAAATATTTTTATGCCACATTTTACAGTAGCCAACTATGGAAATGAATTTCATTTTCTTGAATCAAGAAATCGTGAAATTTA
TCTATGTATAATTTGCAATATTATTTTAAGTCTATTTCACTCTATCTTACGTATCCCTTAGAATACAGATTCTTTTTGCCTGTTTTTCCAGTTTTAGCAT
ATATGCTGCCAAGCATAGAACTGTGAAGGAGAACTGTTAAAGGCGGCCAAATATTTATATACTGATTACATAGAGTCTTGTACATATGTGCTCTAAAAAC
AAACCACCCAGAATTGATACTGTTGGTAACCAGGAGTATAAGGCAGTGGCTCTGGGGTTCTTAATTCATTCCTAACTTCTTTGATACTTCACAGGATTAG
GAAAGTGGTCATCATACATCCCACACAGTCTGTATTACTTCAGGCTTGTGGGCAAGGTTAGGAAGAATCAATCAGCCTTAACTATAAATACCTGCACTGT
CTCTGAGGACTTACTATTTTATGTTCTTTTTAATCAATACCGATCAGAAGTTTAGGTTATAAAAACAATTCTACTTCATGCTTTGGTGCTTGGTAATTTT
TGGTGCGTCTTTAAGCATTACTCTTATATATCATATATTAAAATACCATAAAAATGAAATTCAGACAAAATCACTGGCACCAAAAATGGTTTATTCTGAG
CTGTCTTCACTTTGACTATTTGGGGGGCTTCTCTCAAGTACAGATGTGGGTTGGGGTCCCCTGGAGCAGGCAGGATTGGCAGTAAGAGATATTGGCCACT
CAAGTCTACTGTGTGTGTGTGCCTCTGGAAGAGTGAAGAATGGACTTCAAAAGTAACATCAAAAATCTAACTGCCACCATCCTGGAGACATTTTGCAGGG
CTTTCCTTTCAAGTCTTTCAAGTACAGGATATTACCACAACAGCAGCTGAACTGTTGTAACCAGCATGTTTTTCCTATTTCCACTGTGACCTGCAGCTGA
CTCAAAGCCTTGCGTGACCTGACCCAGGTGCAAGAGACAGGGGAAGAGGGATAGAGGGTATAGCATAAATTACATATTTTCATGGCTTTGGGTGGTTCCT
CCAAAAATAATTGGACCTGTAAAAACTAGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGGTTTTTTTTTTTAATCTTTACTTTGAATTTGTTCCCC
AAGTGTACTTAATCACCTTAGTGCCAGTTTAATCCAGTTATGCAGAAGAAATTCATATTGGTTGCCTGATGTAGAGCTCAGCACCACCCTACCACAGGCC
TTGTCTGGTGTATTTGGGAAGTGGAAAAGAGCCCTCAGTTGGAGGGAGCTGACAACCCTTGGTGGAGGGAGGGTGCCCTTGAATGTATTAAAACTATCAC
CCAAAGAAGGTATGAAAACAGGGTAAGGTGGTCAGTTGTTTGCCAGGTCAATAGACAGAAAGTACATTAGAAAACAGGACTTAGGCCAAACAAACAATAC
TGGATACTGAATACAAAACAGTATGATTTATATTAAAGGTTTCCAAAGGTTGCCTGCAAAGGAGAATATTACTACTAGTCAGCAGGAAAAAAATGCATTC
AGAACCCAAGCAGAAACTGCCAAATGTAATTAGGTTAAGAAAAGTTACCCTTGGGCAGTGTATTAGTTTTCTATTGCTGTGTGACAAATTACCCCAAATT
TAGCAGTTTAAAAAACAATACCCATAGCAGTTCTGTAGCTCATGAGTCTGGCACAGTGTGGCTGGATTCTCTGCTCAGGGTCTTAAAGGCTGAAATAAGG
GTTGGCAGGACAACATTCCTTCATGGAGGCTCTGGGGAAGAATCTGCTTCTAAGTTCATTCAGGTTGTTGGCGGAATTCAGTTCTTTGCTGGCTCTCAGC
TGGAGGCCCCTCTCTCACCTCAAGGCTGCCTGCATTCCTTCTTATGTGGTCCCCTCCAGCTTCAAACCAGCCTTCCTGCTCTTTCTCATGCTTCATATCT
CTCTCCCGTCCTCCTGTTTTAGGGGCATATGATTAGCTCAAGCCCACAGATATATTTTAAGGTTGATTGTGCGATAGAACATAATTGCAGGAGTACTGTC
TCATCTCATCATATTCACGGGTTCTGGAGATTAGCTCATTGAAAGTGGGAGGGGCATTTTCAAATTCTGCCTACCACAGGCAATAACTGCCCATCTCAGC
TGTAGGTGGAATTTTTACCCAGAAAAGATAGGCCCTAGAAGCCTCATTTCTTTTCTCCATGGAAAAGGACAGCCCTCTGCTGCAGCGTTCAACTTGTGTG
TTTACTGACAGAGTGAACTACAGAAATAGCTTTTCTTCCTAAAGGGGATTGTTCTACATTTTGAAGTTATTTTTTAATAAAATTGAATTATGTTGTGTAT
TGTGCTTCTTAATAGGAAATGCATTATTGGACTGTTTTTGTAACATCCTGTTTATTGCAAATAGCTAGTATCGTTCAAAAACTGTATAAAATACTTTTGT
ACATATTAGCAATGTCTAATTTGTATACACTTCAGTTAAATTTCCCTAAAACTTGAAAGGGGACCTTGTAGAAATTAAAATATATACTTAGTCTAAGTCT
GA
  • refseq_NKTR.F2 (forward primer)
  • refseq_NKTR.R2 (reverse primer)
  • Single exon skipping

Frame 0

VALGGPAWGRRRRSVSGVGVWLQWQCFLFCSRG
PAQAGGQPALAATSVAMGAQDRPQCHFDIEINRE
PVGRIMFQLFSDICPKTCKNFLCLCSGEKGLGK
TTGKKLCYKGSTFHRVVKNFMIQGGDFSEGNGK
GGESIYGGYFKDENFILKHDRAFLLSMANRGKHT
NGSQFFITTKPAPHLDGVHVVFGLVISGFEVIE
QIENLKTDAASRPYADVRVIDCGVLATKSIKDV
FEKKRKKPTHSEGSDSSSNSSSSSESSSESELEH
ERSRRRKHKRRPKVKRSKKRRKEASSSEEPRNK
HAMNPKGHSERSDTNEKRSVDSSAKREKPVVRP
EEIPPVPENRFLLRRDMPVVTAEPEPKIPDVAPI
VSDQKPSVSKSGRKIKGRGTIRYHTPPRSRSCS
ESDDDDSSETPPHWKEEMQRLRAYRPPSGEKWS
KGDKLSDPCSSRWDERSLSQRSRSWSYNGYYSDL
STARHSGHHKKRRKEKKVKHKKKGKKQKHCRRH
KQTKKRRILIPSDIESSKSSTRRMKSSCDRERS
SRSSSLSSHHSSKRDWSKSDKDVQSSLTHSSRDS
YRSKSHSQSYSRGSSRSRTASKSSSHSRSRSKS
RSSSKSGHRKRASKSPRKTASQLSENKPVKTEP
LRATMAQNENVVVQPVVAENIPVIPLSDSPPPSR
WKPGQKPWKPSYERIQEMKAKTTHLLPIQSTYS
LANIKETGSSSSYHKREKNSESDQSTYSKYSDR
SSESSPRSRSRSSRSRSYSRSYTRSRSLASSHSR
SRSPSSRSHSRNKYSDHSQCSRSSSYTSISSDD
GRRAKRRLRSSGKKNSVSHKKHSSSSEKTLHSK
YVKGRDRSSCVRKYSESRSSLDYSSDSEQSSVQA
TQSAQEKEKQGQMERTHNKQEKNRGEEKSKSER
ECPHSKKRTLKENLSDHLRNGSKPKRKNYAGSK
WDSESNSERDVTKNSKNDSHPSSDKEEGEATSDS
ESEVSEIHIKVKPTTKSSTNTSLPDDNGAWKSS
KQRTSTSDSEGSCSNSENNRGKPQKHKHGSKEN
LKREHTKKVKEKLKGKKDKKHKAPKRKQAFHWQP
PLEFGEEEEEEIDDKQVTQESKEKKVSENNETI
KDNILKTEKSSEEDLSGKHDTVTVSSDLDQFTK
DDSKLSISPTALNTEENVACLQNIQHVEESVPNG
VEDVLQTDDNMEICTPDRSSPAKVEETSPLGNA
RLDTPDINIVLKQDMATEHPQAEVVKQESSMSE
SKVLGEVGKQDSSSASLASAGESTGKKEVAEKSQ
INLIDKKWKPLQGVGNLAAPNAATSSAVEVKVL
TTVPEMKPQGLRIEIKSKNKVRPGSLFDEVRKT
ARLNRRPRNQESSSDEQTPSRDDDSQSRSPSRSR
SKSETKSRHRTRSVSYSHSRSRSRSSTSSYRSR
SYSRSRSRGWYSRGRTRSRSSSYRSYKSHRTSS
RSRSRSSSYDPHSRSRSYTYDSYYSRSRSRSRSQ
RSDSYHRGRSYNRRSRSCRSYGSDSESDRSYSH
HRSPSESSRYS*KRPDTNYILFVNIWQLSLRNV
MTVCCSISISEVNFKNRHFLIVTGSFTCGEKNLK
YRYVS*KYFYATFYSSQLWK*ISFS*IKKS*NL
SMYNLQYYFKSISLYLTYPLEYRFFLPVFPVLA
YMLPSIEL*RRTVKGGQIFIY*LHRVLYICALKT
NHPELILLVTRSIRQWLWGS*FIPNFFDTSQD*
ESGHHTSHTVCITSGLWARLGRINQP*L*IPAL
SLRTYYFMFFLINTDQKFRL*KQFYFMLWCLVIF
GASLSITLIYHILKYHKNEIQTKSLAPKMVYSE
LSSL*LFGGLLSSTDVGWGPLEQAGLAVRDIGH
SSLLCVCASGRVKNGLQK*HQKSNCHHPGDILQG
FPFKSFKYRILPQQQLNCCNQHVFPISTVTCS*
LKALRDLTQVQETGEEG*RV*HKLHIFMALGGS
SKNNWTCKN*CVCVCVCVCVCGFFF*SLL*ICSP
SVLNHLSASLIQLCRRNSYWLPDVELSTTLPQA
LSGVFGKWKRALSWRELTTLGGGRVPLNVLKLS
PKEGMKTG*GGQLFARSIDRKYIRKQDLGQTNNT
GY*IQNSMIYIKGFQRLPAKENITTSQQEKNAF
RTQAETAKCN*VKKSYPWAVY*FSIAV*QITPN
LAV*KTIPIAVL*LMSLAQCGWILCSGS*RLK*G
LAGQHSFMEALGKNLLLSSFRLLAEFSSLLALS
WRPLSHLKAACIPSYVVPSSFKPAFLLFLMLHI
SLPSSCFRGI*LAQAHRYILRLIVR*NIIAGVLS
HLIIFTGSGD*LIESGRGIFKFCLPQAITAHLS
CRWNFYPEKIGPRSLISFLHGKGQPSAAAFNLC
VY*QSELQK*LFFLKGIVLHFEVIF**N*IMLCI
VLLNRKCIIGLFL*HPVYCK*LVSFKNCIKYFC
TY*QCLICIHFS*ISLKLERGPCRN*NIYLV*V
*

Frame 1

WHWEARPGGGDGVPLAALGFGCSGSAFSSAHGD
PLRLEASQLLPPPRSRWGRRTGRSATSTSRSTG
SRLVALCFSSSQTYVQKHAKTSFACAQERKALGK
QLGRSYVIKVLRSIVWLKTL*FRVGTSVKVMEK
VENQFMVDILKMKTLFSNMTERSFYQWQIEGNI
PMVPSFSLPQSLLHTWMGCM*SLDWLFLVLK*SN
KLKI*RPMLQADHMQMCELLTVEYLPQNQ*KMF
LRKKGRNQLIQKARIPLPIPPLLQNHLQKVNLN
MREAEGGNIRGGQKLNVLKRGERKQAVQKSQGIN
MQ*TQKVTLRGVIPMKKGQLIPVLKGKNLWSAQ
KRFLQCLRTDFY*EEICLLLLQNLNRRFLMLHP
L*VIRNHLYQSLDGRLKEGAQFAITHLQDQDPVL
SQMMMTAVKLLLTGKRKCRD*EHIDHLVEKNGV
KEIS*VTPVQADGMKEACLRDPDHGPIMDIIQT
LVQQDTLATIKNAEKKKRLSIKRKGKSRNTAEDT
NKQRREGFLYRLT*NPQNLPLEE*NPLVIEKGV
LVLPHCHLITHQRETGLNLIRMSRAL*PIPAET
HTDQNLTHSLILEEAQDQGLRQSPHHILEVDQSP
DLVPSLGTEREHQNHQEKQLLS*VKINQLKQNL
*EQPWHKMKM**YNQL*QKIFL*YH*VTVPPLQ
DGSLDRNLGSPLMSEFRK*KLKQPICYPSKALTV
*QILKRLVAHHPTIKEKKIRKVIRALIQNTVIE
VQKAHQGQGADLLGVDLIPDHIQDHVV*LVHIQ
GLGLHHLDLIHEINTVIIHSVVDHLHILLLAVMM
EGELRGDLDPVGKKIAFHIKSIAAALKRHFTVN
MSKVETGLHV*ESIARADHL*IILQTVSSQVFR
PHSQPRKKRSRAKWKEHIINKKKTEVKKNPSLNG
NALIQKKEL*KRIFLITLEMAVSPKGRIMLVVN
GTLSQIQNEMSLKTVKMTPIHPLTRKKVRPHPI
LNQRLVKFTSKSNPQPSRPQILHCLMIMVLGNQA
NSAHQLLTLRGPVPIRKTIGESHKSTNMGQRKI
LKENTPKK*KRN*KGKKTKSIRLQNESKHFTGS
LH*NLVKRRRRRLMTSKLLRNQKRKKFLKTMKP*
KIIF*KLRNPVKRTFQVNMIQ*LFHQILISLLK
MIVNSVFLPQL*ILRKMWPVYKTFSTLKKVFPM
EWKMCFKQMTTWRSALLIGVPQQK*RRLPL*EMH
GLIPQI*TLF*SRIWQRNILKQR**NRKAACPK
VKCWVKWGNRTAALLAWLVLEKVPGRRRWLRRA
RSTSLIRNGSPCKVWGTWQHLMLPHPVLWKLRC*
PLCLK*NHKA*E*KLKAKIKFGLGLSLMK*ERQ
HA*TVDQEIRRVQVMSRRLVGMMIASPGVQVDL
EVNLKPNQDTEQGLSPIVTQEVDREVPHHLIDQE
ATLEVGAEDGTAEAEPEAGAVPTGVTKVTGRPA
GADPGAAHMIPTVDPGPTPTIATIAGVGVEVEA
REVTVTTEAEVIIGGPGVVDLMALTVKVTEVTLI
TGAPVRAADTVENVRIQIISYL*ISGNLA*EM*
*QSVVLFQYQR*ISKIDTS*LLLVHLHVGRRI*
NTDMSPKNIFMPHFTVANYGNEFHFLESRNREIY
LCIICNIILSLFHSILRIP*NTDSFCLFFQF*H
ICCQA*NCEGELLKAAKYLYTDYIESCTYVL*K
QTTQN*YCW*PGV*GSGSGVLNSFLTSLILHRIR
KVVIIHPTQSVLLQACGQG*EESISLNYKYLHC
L*GLTILCSF*SIPIRSLGYKNNSTSCFGAW*F
LVRL*ALLLYIIY*NTIKMKFRQNHWHQKWFILS
CLHFDYLGGFSQVQMWVGVPWSRQDWQ*EILAT
QVYCVCVPLEE*RMDFKSNIKNLTATILETFCR
AFLSSLSSTGYYHNSS*TVVTSMFFLFPL*PAAD
SKPCVT*PRCKRQGKRDRGYSINYIFSWLWVVP
PKIIGPVKTSVCVCVCVCVCVVFFFNLYFEFVP
QVYLITLVPV*SSYAEEIHIGCLM*SSAPPYHRP
CLVYLGSGKEPSVGGS*QPLVEGGCP*MY*NYH
PKKV*KQGKVVSCLPGQ*TESTLENRT*AKQTI
LDTEYKTV*FILKVSKGCLQRRILLLVSRKKMHS
EPKQKLPNVIRLRKVTLGQCISFLLLCDKLPQI
*QFKKQYP*QFCSS*VWHSVAGFSAQGLKG*NK
GWQDNIPSWRLWGRICF*VHSGCWRNSVLCWLSA
GGPSLTSRLPAFLLMWSPPASNQPSCSFSCFIS
LSRPPVLGAYD*LKPTDIF*G*LCDRT*LQEYC
LISSYSRVLEISSLKVGGAFSNSAYHRQ*LPISA
VGGIFTQKR*ALEASFLFSMEKDSPLLQRSTCV
FTDRVNYRNSFSS*RGLFYILKLFFNKIELCCV
LCFLIGNALLDCFCNILFIANS*YRSKTV*NTFV
HISNV*FVYTSVKFP*NLKGDLVEIKIYT*SKS

Frame 2

GIGRPGLGEETAFR*RRWGLAAVAVLSLLLTGT
RSGWRPASSCRHLGRDGGAGPAAVPLRHRDQPG
AGWSHYVSALLRHMSKNMQKLPLLVLRRERPWE
NNWEEVML*RFYVPSCG*KLYDSGWGLQ*R*WKR
WRINLWWIF*R*KLYSQT*QSVPFINGKSRETY
QWFPVFHYHKACSTPGWGACSLWTGYFWF*SNR
TN*KSEDRCCKQTICRCASY*LWSTCHKINKRCF
*EKKEETNSFRRLGFLFQFLLFFRIIFRK*T*T
*EKQKEET*EEAKS*TF*KEAKGSKQFRRAKE*
TCNEPKRSL*EE*YQ*KKVS*FQC*KGKTCGPPR
RDSSSA*EPIFTEKRYACCYCRT*TEDS*CCTH
CK*SETICIKVWTED*RKGHNSLSHTSKIKILF
*VR***QQ*NSSSLERGNAEIKSI*TT*WRKME*
RR*VK*PLFKPMG*KKLVSEIQIMVL*WILFRP
*YSKTLWPP*KTQKRKKG*A*KEREKAETLQKT
QTNKEEKDSYTV*HRILKIFHSKNEILL**RKEF
SFFLIVISSLIKERLV*I**GCPELFNPFQQRL
IQIKISLTVLF*RKLKIKDCVKVLITFSK*IKV
QI*FQVWAPKESIKITKKNSFSVK*K*TS*NRTF
KSNHGTK*KCSSTTSCSRKYSCNTTE*QSPPFK
MEAWTETLEALL*ANSGNES*NNPFATHPKHLQ
FSKY*RDW*LIILP*KRKKFGK*SEHLFKIQ**K
FRKLTKVKEQIF*E*ILFQIIYKIT*SS*FTFK
V*VSII*ISFTK*IQ*SFTV**IIFIYFY*Q**
WKAS*EET*IQWEKK*RFT*KA*QQL*KDTSQ*I
CQR*RQVFMCEKV*REQIIFRLFFRQ*AVKCSG
HTVSPGKREAGPNGKNT**TRKKQR*RKIQV*T
GMPSFKKKNFERESF*SP*KWQ*AQKEELCW**M
GL*VKFRTRCH*KQ*K*LPSIL*QGRR*GHIRF
*IRG**NSHQSQTHNQVVHKYFTA***WCLEIK
QTAHINF*L*GVLFQFGKQ*GKATKAQTWVKGKS
*KRTHQKSEREIEREKRQKA*GSKTKASISLAA
STRIW*RGGGGD**QASYSGIKREKSF*KQ*NH
KR*YSKN*EIQ*RGPFR*T*YSDCFIRS*SVY*R
***TQYFSHSFKY*GKCGLFTKHSAR*RKCSQW
SGRCASNR*QHGDLHS**EFPSKSRGDFPSRKC
TA*YPRYKHCFEAGYGNGTSSSRGSKTGKQHVRK
*SVG*SGETGQQLC*LG*CWRKYREEGGG*EEP
DQPH**EMEAPARCGEPGST*CCHIQCCGS*GV
DHCA*NETTRLENRN*KQK*SSAWVSL**SKKDS
TLKP*TKKSGEFK**ADA*SG***PVQESK*IS
K*I*NQIKTQNKVCLL*SLKKSIEKFHIILSIK
KLL*KSEQRMVQQRPNQKPEQFLPELQKSQDVQQ
EQIQEQLI*SPQSIQVLHLR*LL*QESESK*KP
EK*QLPPRQKL*SAVQEL*ILWL*Q*K*PKLLS
SPEPQ*EQQIQLKTSGYKLYLICKYLAT*LKKCN
DSLLFYFNIRGEFQK*TLLNCYWFIYMWGEEFK
IQICLLKIFLCHILQ*PTMEMNFIFLNQEIVKF
IYV*FAILF*VYFTLSYVSLRIQILFACFSSFSI
YAAKHRTVKENC*RRPNIYILIT*SLVHMCSKN
KPPRIDTVGNQEYKAVALGFLIHS*LL*YFTGL
GKWSSYIPHSLYYFRLVGKVRKNQSALTINTCTV
SEDLLFYVLFNQYRSEV*VIKTILLHALVLGNF
WCVFKHYSYISYIKIP*K*NSDKITGTKNGLF*
AVFTLTIWGASLKYRCGLGSPGAGRIGSKRYWPL
KSTVCVCLWKSEEWTSKVTSKI*LPPSWRHFAG
LSFQVFQVQDITTTAAELL*PACFSYFHCDLQL
TQSLA*PDPGARDRGRGIEGIA*ITYFHGFGWFL
QK*LDL*KLVCVCVCVCVCVWFFFLIFTLNLFP
KCT*SP*CQFNPVMQKKFILVA*CRAQHHPTTG
LVWCIWEVEKSPQLEGADNPWWREGALECIKTIT
QRRYENRVRWSVVCQVNRQKVH*KTGLRPNKQY
WILNTKQYDLY*RFPKVACKGEYYY*SAGKKCI
QNPSRNCQM*LG*EKLPLGSVLVFYCCVTNYPKF
SSLKNNTHSSSVAHESGTVWLDSLLRVLKAEIR
VGRTTFLHGGSGEESASKFIQVVGGIQFFAGSQ
LEAPLSPQGCLHSFLCGPLQLQTSLPALSHASYL
SPVLLF*GHMISSSPQIYFKVDCAIEHNCRSTV
SSHHIHGFWRLAH*KWEGHFQILPTTGNNCPSQ
L*VEFLPRKDRP*KPHFFSPWKRTALCCSVQLVC
LLTE*TTEIAFLPKGDCSTF*SYFLIKLNYVVY
CAS**EMHYWTVFVTSCLLQIASIVQKLYKILL
YILAMSNLYTLQLNFPKT*KGTL*KLKYILSLSL

Sequence NM_001012651

GTGGCATTGGGAGGCCCGGCCTGGGGGAGGAGACGGCGTTCCGTTAGCGGCGTTGGGGTTTGGCTGCAGTGGCAGTGCTTTCTCTTCTGCTCACGGGGAC
CCGCTCAGGCTGGAGGCCAGCCAGCTCTTGCCGCCACCTCGGTCGCGATGGGGGCGCAGGACCGGCCGCAGTGCCACTTCGACATCGAGATCAACCGGGA
GCCGGTTGGTCGCATTATGTTTCAGCTCTTCTCAGACATATGTCCAAAAACATGCAAAAACTTCCTTTGCTTGTGCTCAGGAGAGAAAGGCCTTGGGAAA
ACAACTGGGAAGAAGTTATGTTATAAAGGTTCTACGTTCCATCGTGTGGTTAAAAACTTTATGATTCAGGGTGGGGACTTCAGTGAAGGTAATGGAAAAG
GTGGAGAATCAATTTATGGTGGATATTTTAAAGAGAATGTGGTCTTTTGCAAAATGAAAAGATGAAAACTTTATTCTCAAACATGACAGAGCGTTCCTTT
TATCAATGGCAAATCGAGGGAAACATACCAATGGTTCCCAGTTTTTCATAAAGAGTGTTACACCGTGCGCTCCAAAGTACCACAAAGCCTGCTCCACACC
TGGATGGGGTGCATGTAGTCTTTGGACTGGTTATTTCTGGTTTTGAAGTAATCGAACAAATTGAAAATCTGAAGACCGATGCTGCAAGCAGACCATATGC
AGATGTGCGAGTTATTGACTGTGGAGTACTTGCCACAAAATCAATAAAAGATGTTTTTGAGAAAAAAAGGAAGAAACCAACTCATTCAGAAGGCTCGGAT
TCCTCTTCCAATTCCTCCTCTTCTTCAGAATCATCTTCAGAAAGTGAACTTGAACATGAGAGAAGCAGAAGGAGGAAACATAAGAGGAGGCCAAAAGTTA
AACGTTCTAAAAAGAGGCGAAAGGAAGCAAGCAGTTCAGAAGAGCCAAGGAATAAACATGCAATGAACCCAAAAGGTCACTCTGAGAGGAGTGATACCAA
TGAAAAAAGGTCAGTTGATTCCAGTGCTAAAAGGGAAAAACCTGTGGTCCGCCCAGAAGAGATTCCTCCAGTGCCTGAGAACCGATTTTTACTGAGAAGA
GATATGCCTGTTGTTACTGCAGAACCTGAACCGAAGATTCCTGATGTTGCACCCATTGTAAGTGATCAGAAACCATCTGTATCAAAGTCTGGACGGAAGA
TTAAAGGAAGGGGCACAATTCGCTATCACACACCTCCAAGATCAAGATCCTGTTCTGAGTCAGATGATGATGACAGCAGTGAAACTCCTCCTCACTGGAA
AGAGGAAATGCAGAGATTAAGAGCATATAGACCACCTAGTGGAGAAAAATGGAGTAAAGGAGATAAGTTAAGTGACCCCTGTTCAAGCCGATGGGATGAA
AGAAGCTTGTCTCAGAGATCCAGATCATGGTCCTATAATGGATATTATTCAGACCTTAGTACAGCAAGACACTCTGGCCACCATAAAAAACGCAGAAAAG
AAAAAAAGGTTAAGCATAAAAAGAAAGGGAAAAAGCAGAAACACTGCAGAAGACACAAACAAACAAAGAAGAGAAGGATTCTTATACCGTCTGACATAGA
ATCCTCAAAATCTTCCACTCGAAGAATGAAATCCTCTTGTGATAGAGAAAGGAGTTCTCGTTCTTCCTCATTGTCATCTCATCACTCATCAAAGAGAGAC
TGGTCTAAATCTGATAAGGATGTCCAGAGCTCTTTAACCCATTCCAGCAGAGACTCATACAGATCAAAATCTCACTCACAGTCTTATTCTAGAGGAAGCT
CAAGATCAAGGACTGCGTCAAAGTCCTCATCACATTCTCGAAGTAGATCAAAGTCCAGATCTAGTTCCAAGTCTGGGCACCGAAAGAGAGCATCAAAATC
ACCAAGAAAAACAGCTTCTCAGTTAAGTGAAAATAAACCAGTTAAAACAGAACCTTTAAGAGCAACCATGGCACAAAATGAAAATGTAGTAGTACAACCA
GTTGTAGCAGAAAATATTCCTGTAATACCACTGAGTGACAGTCCCCCCCCTTCAAGATGGAAGCCTGGACAGAAACCTTGGAAGCCCTCTTATGAGCGAA
TTCAGGAAATGAAAGCTAAAACAACCCATTTGCTACCCATCCAAAGCACTTACAGTTTAGCAAATATTAAAGAGACTGGTAGCTCATCATCCTACCATAA
AAGAGAAAAAAATTCGGAAAGTGATCAGAGCACTTATTCAAAATACAGTGATAGAAGTTCAGAAAGCTCACCAAGGTCAAGGAGCAGATCTTCTAGGAGT
AGATCTTATTCCAGATCATATACAAGATCACGTAGTCTAGCTAGTTCACATTCAAGGTCTAGGTCTCCATCATCTAGATCTCATTCACGAAATAAATACA
GTGATCATTCACAGTGTAGTAGATCATCTTCATATACTTCTATTAGCAGTGATGATGGAAGGCGAGCTAAGAGGAGACTTAGATCCAGTGGGAAAAAAAA
TAGCGTTTCACATAAAAAGCATAGCAGCAGCTCTGAAAAGACACTTCACAGTAAATATGTCAAAGGTAGAGACAGGTCTTCATGTGTGAGAAAGTATAGC
GAGAGCAGATCATCTTTAGATTATTCTTCAGACAGTGAGCAGTCAAGTGTTCAGGCCACACAGTCAGCCCAGGAAAAAGAGAAGCAGGGCCAAATGGAAA
GAACACATAATAAACAAGAAAAAAACAGAGGTGAAGAAAAATCCAAGTCTGAACGGGAATGCCCTCATTCAAAAAAAAGAACTTTGAAAGAGAATCTTTC
TGATCACCTTAGAAATGGCAGTAAGCCCAAAAGGAAGAATTATGCTGGTAGTAAATGGGACTCTGAGTCAAATTCAGAACGAGATGTCACTAAAAACAGT
AAAAATGACTCCCATCCATCCTCTGACAAGGAAGAAGGTGAGGCCACATCCGATTCTGAATCAGAGGTTAGTGAAATTCACATCAAAGTCAAACCCACAA
CCAAGTCGTCCACAAATACTTCACTGCCTGATGATAATGGTGCTTGGAAATCAAGCAAACAGCGCACATCAACTTCTGACTCTGAGGGGTCCTGTTCCAA
TTCGGAAAACAATAGGGGAAAGCCACAAAAGCACAAACATGGGTCAAAGGAAAATCTTAAAAGAGAACACACCAAAAAAGTGAAAGAGAAATTGAAAGGG
AAAAAAGACAAAAAGCATAAGGCTCCAAAACGAAAGCAAGCATTTCACTGGCAGCCTCCACTAGAATTTGGTGAAGAGGAGGAGGAGGAGATTGATGACA
AGCAAGTTACTCAGGAATCAAAAGAGAAAAAAGTTTCTGAAAACAATGAAACCATAAAAGATAATATTCTAAAAACTGAGAAATCCAGTGAAGAGGACCT
TTCAGGTAAACATGATACAGTGACTGTTTCATCAGATCTTGATCAGTTTACTAAAGATGATAGTAAACTCAGTATTTCTCCCACAGCTTTAAATACTGAG
GAAAATGTGGCCTGTTTACAAAACATTCAGCACGTTGAAGAAAGTGTTCCCAATGGAGTGGAAGATGTGCTTCAAACAGATGACAACATGGAGATCTGCA
CTCCTGATAGGAGTTCCCCAGCAAAAGTAGAGGAGACTTCCCCTCTAGGAAATGCACGGCTTGATACCCCAGATATAAACATTGTTTTGAAGCAGGATAT
GGCAACGGAACATCCTCAAGCAGAGGTAGTAAAACAGGAAAGCAGCATGTCCGAAAGTAAAGTGTTGGGTGAAGTGGGGAAACAGGACAGCAGCTCTGCT
AGCTTGGCTAGTGCTGGAGAAAGTACCGGGAAGAAGGAGGTGGCTGAGAAGAGCCAGATCAACCTCATTGATAAGAAATGGAAGCCCCTGCAAGGTGTGG
GGAACCTGGCAGCACCTAATGCTGCCACATCCAGTGCTGTGGAAGTTAAGGTGTTGACCACTGTGCCTGAAATGAAACCACAAGGCTTGAGAATAGAAAT
TAAAAGCAAAAATAAAGTTCGGCCTGGGTCTCTCTTTGATGAAGTAAGAAAGACAGCACGCTTAAACCGTAGACCAAGAAATCAGGAGAGTTCAAGTGAT
GAGCAGACGCCTAGTCGGGATGATGATAGCCAGTCCAGGAGTCCAAGTAGATCTCGAAGTAAATCTGAAACCAAATCAAGACACAGAACAAGGTCTGTCT
CCTATAGTCACTCAAGAAGTCGATCGAGAAGTTCCACATCATCTTATCGATCAAGAAGCTACTCTAGAAGTCGGAGCAGAGGATGGTACAGCAGAGGCCG
AACCAGAAGCCGGAGCAGTTCCTACCGGAGTTACAAAAGTCACAGGACGTCCAGCAGGAGCAGATCCAGGAGCAGCTCATATGATCCCCACAGTCGATCC
AGGTCCTACACCTACGATAGCTACTATAGCAGGAGTCGGAGTCGAAGTAGAAGCCAGAGAAGTGACAGTTACCACCGAGGCAGAAGTTATAATCGGCGGT
CCAGGAGTTGTAGATCTTATGGCTCTGACAGTGAAAGTGACCGAAGTTACTCTCATCACCGGAGCCCCAGTGAGAGCAGCAGATACAGTTGAAAACGTCC
GGATACAAATTATATCTTATTTGTAAATATCTGGCAACTTAGCTTAAGAAATGTAATGACAGTCTGTTGTTCTATTTCAATATCAGAGGTGAATTTCAAA
AATAGACACTTCTTAATTGTTACTGGTTCATTTACATGTGGGGAGAAGAATTTAAAATACAGATATGTCTCCTAAAAATATTTTTATGCCACATTTTACA
GTAGCCAACTATGGAAATGAATTTCATTTTCTTGAATCAAGAAATCGTGAAATTTATCTATGTATAATTTGCAATATTATTTTAAGTCTATTTCACTCTA
TCTTACGTATCCCTTAGAATACAGATTCTTTTTGCCTGTTTTTCCAGTTTTAGCATATATGCTGCCAAGCATAGAACTGTGAAGGAGAACTGTTAAAGGC
GGCCAAATATTTATATACTGATTACATAGAGTCTTGTACATATGTGCTCTAAAAACAAACCACCCAGAATTGATACTGTTGGTAACCAGGAGTATAAGGC
AGTGGCTCTGGGGTTCTTAATTCATTCCTAACTTCTTTGATACTTCACAGGATTAGGAAAGTGGTCATCATACATCCCACACAGTCTGTATTACTTCAGG
CTTGTGGGCAAGGTTAGGAAGAATCAATCAGCCTTAACTATAAATACCTGCACTGTCTCTGAGGACTTACTATTTTATGTTCTTTTTAATCAATACCGAT
CAGAAGTTTAGGTTATAAAAACAATTCTACTTCATGCTTTGGTGCTTGGTAATTTTTGGTGCGTCTTTAAGCATTACTCTTATATATCATATATTAAAAT
ACCATAAAAATGAAATTCAGACAAAATCACTGGCACCAAAAATGGTTTATTCTGAGCTGTCTTCACTTTGACTATTTGGGGGGCTTCTCTCAAGTACAGA
TGTGGGTTGGGGTCCCCTGGAGCAGGCAGGATTGGCAGTAAGAGATATTGGCCACTCAAGTCTACTGTGTGTGTGTGCCTCTGGAAGAGTGAAGAATGGA
CTTCAAAAGTAACATCAAAAATCTAACTGCCACCATCCTGGAGACATTTTGCAGGGCTTTCCTTTCAAGTCTTTCAAGTACAGGATATTACCACAACAGC
AGCTGAACTGTTGTAACCAGCATGTTTTTCCTATTTCCACTGTGACCTGCAGCTGACTCAAAGCCTTGCGTGACCTGACCCAGGTGCAAGAGACAGGGGA
AGAGGGATAGAGGGTATAGCATAAATTACATATTTTCATGGCTTTGGGTGGTTCCTCCAAAAATAATTGGACCTGTAAAAACTAGTGTGTGTGTGTGTGT
GTGTGTGTGTGTGTGTGTGGTTTTTTTTTTTAATCTTTACTTTGAATTTGTTCCCCAAGTGTACTTAATCACCTTAGTGCCAGTTTAATCCAGTTATGCA
GAAGAAATTCATATTGGTTGCCTGATGTAGAGCTCAGCACCACCCTACCACAGGCCTTGTCTGGTGTATTTGGGAAGTGGAAAAGAGCCCTCAGTTGGAG
GGAGCTGACAACCCTTGGTGGAGGGAGGGTGCCCTTGAATGTATTAAAACTATCACCCAAAGAAGGTATGAAAACAGGGTAAGGTGGTCAGTTGTTTGCC
AGGTCAATAGACAGAAAGTACATTAGAAAACAGGACTTAGGCCAAACAAACAATACTGGATACTGAATACAAAACAGTATGATTTATATTAAAGGTTTCC
AAAGGTTGCCTGCAAAGGAGAATATTACTACTAGTCAGCAGGAAAAAAATGCATTCAGAACCCAAGCAGAAACTGCCAAATGTAATTAGGTTAAGAAAAG
TTACCCTTGGGCAGTGTATTAGTTTTCTATTGCTGTGTGACAAATTACCCCAAATTTAGCAGTTTAAAAAACAATACCCATAGCAGTTCTGTAGCTCATG
AGTCTGGCACAGTGTGGCTGGATTCTCTGCTCAGGGTCTTAAAGGCTGAAATAAGGGTTGGCAGGACAACATTCCTTCATGGAGGCTCTGGGGAAGAATC
TGCTTCTAAGTTCATTCAGGTTGTTGGCGGAATTCAGTTCTTTGCTGGCTCTCAGCTGGAGGCCCCTCTCTCACCTCAAGGCTGCCTGCATTCCTTCTTA
TGTGGTCCCCTCCAGCTTCAAACCAGCCTTCCTGCTCTTTCTCATGCTTCATATCTCTCTCCCGTCCTCCTGTTTTAGGGGCATATGATTAGCTCAAGCC
CACAGATATATTTTAAGGTTGATTGTGCGATAGAACATAATTGCAGGAGTACTGTCTCATCTCATCATATTCACGGGTTCTGGAGATTAGCTCATTGAAA
GTGGGAGGGGCATTTTCAAATTCTGCCTACCACAGGCAATAACTGCCCATCTCAGCTGTAGGTGGAATTTTTACCCAGAAAAGATAGGCCCTAGAAGCCT
CATTTCTTTTCTCCATGGAAAAGGACAGCCCTCTGCTGCAGCGTTCAACTTGTGTGTTTACTGACAGAGTGAACTACAGAAATAGCTTTTCTTCCTAAAG
GGGATTGTTCTACATTTTGAAGTTATTTTTTAATAAAATTGAATTATGTTGTGTATTGTGCTTCTTAATAGGAAATGCATTATTGGACTGTTTTTGTAAC
ATCCTGTTTATTGCAAATAGCTAGTATCGTTCAAAAACTGTATAAAATACTTTTGTACATATTAGCAATGTCTAATTTGTATACACTTCAGTTAAATTTC
CCTAAAACTTGAAAGGGGACCTTGTAGAAATTAAAATATATACTTAGTCTAAGTCTGA
  • refseq_NKTR.F2 (forward primer)
  • refseq_NKTR.R2 (reverse primer)
  • Single exon skipping

Frame 0

VALGGPAWGRRRRSVSGVGVWLQWQCFLFCSRG
PAQAGGQPALAATSVAMGAQDRPQCHFDIEINRE
PVGRIMFQLFSDICPKTCKNFLCLCSGEKGLGK
TTGKKLCYKGSTFHRVVKNFMIQGGDFSEGNGK
GGESIYGGYFKENVVFCKMKR*KLYSQT*QSVPF
INGKSRETYQWFPVFHKECYTVRSKVPQSLLHT
WMGCM*SLDWLFLVLK*SNKLKI*RPMLQADHM
QMCELLTVEYLPQNQ*KMFLRKKGRNQLIQKARI
PLPIPPLLQNHLQKVNLNMREAEGGNIRGGQKL
NVLKRGERKQAVQKSQGINMQ*TQKVTLRGVIP
MKKGQLIPVLKGKNLWSAQKRFLQCLRTDFY*EE
ICLLLLQNLNRRFLMLHPL*VIRNHLYQSLDGR
LKEGAQFAITHLQDQDPVLSQMMMTAVKLLLTG
KRKCRD*EHIDHLVEKNGVKEIS*VTPVQADGMK
EACLRDPDHGPIMDIIQTLVQQDTLATIKNAEK
KKRLSIKRKGKSRNTAEDTNKQRREGFLYRLT*
NPQNLPLEE*NPLVIEKGVLVLPHCHLITHQRET
GLNLIRMSRAL*PIPAETHTDQNLTHSLILEEA
QDQGLRQSPHHILEVDQSPDLVPSLGTEREHQN
HQEKQLLS*VKINQLKQNL*EQPWHKMKM**YNQ
L*QKIFL*YH*VTVPPLQDGSLDRNLGSPLMSE
FRK*KLKQPICYPSKALTV*QILKRLVAHHPTI
KEKKIRKVIRALIQNTVIEVQKAHQGQGADLLGV
DLIPDHIQDHVV*LVHIQGLGLHHLDLIHEINT
VIIHSVVDHLHILLLAVMMEGELRGDLDPVGKK
IAFHIKSIAAALKRHFTVNMSKVETGLHV*ESIA
RADHL*IILQTVSSQVFRPHSQPRKKRSRAKWK
EHIINKKKTEVKKNPSLNGNALIQKKEL*KRIF
LITLEMAVSPKGRIMLVVNGTLSQIQNEMSLKTV
KMTPIHPLTRKKVRPHPILNQRLVKFTSKSNPQ
PSRPQILHCLMIMVLGNQANSAHQLLTLRGPVP
IRKTIGESHKSTNMGQRKILKENTPKK*KRN*KG
KKTKSIRLQNESKHFTGSLH*NLVKRRRRRLMT
SKLLRNQKRKKFLKTMKP*KIIF*KLRNPVKRT
FQVNMIQ*LFHQILISLLKMIVNSVFLPQL*ILR
KMWPVYKTFSTLKKVFPMEWKMCFKQMTTWRSA
LLIGVPQQK*RRLPL*EMHGLIPQI*TLF*SRI
WQRNILKQR**NRKAACPKVKCWVKWGNRTAALL
AWLVLEKVPGRRRWLRRARSTSLIRNGSPCKVW
GTWQHLMLPHPVLWKLRC*PLCLK*NHKA*E*K
LKAKIKFGLGLSLMK*ERQHA*TVDQEIRRVQVM
SRRLVGMMIASPGVQVDLEVNLKPNQDTEQGLS
PIVTQEVDREVPHHLIDQEATLEVGAEDGTAEA
EPEAGAVPTGVTKVTGRPAGADPGAAHMIPTVDP
GPTPTIATIAGVGVEVEAREVTVTTEAEVIIGG
PGVVDLMALTVKVTEVTLITGAPVRAADTVENV
RIQIISYL*ISGNLA*EM**QSVVLFQYQR*ISK
IDTS*LLLVHLHVGRRI*NTDMSPKNIFMPHFT
VANYGNEFHFLESRNREIYLCIICNIILSLFHS
ILRIP*NTDSFCLFFQF*HICCQA*NCEGELLKA
AKYLYTDYIESCTYVL*KQTTQN*YCW*PGV*G
SGSGVLNSFLTSLILHRIRKVVIIHPTQSVLLQ
ACGQG*EESISLNYKYLHCL*GLTILCSF*SIPI
RSLGYKNNSTSCFGAW*FLVRL*ALLLYIIY*N
TIKMKFRQNHWHQKWFILSCLHFDYLGGFSQVQ
MWVGVPWSRQDWQ*EILATQVYCVCVPLEE*RMD
FKSNIKNLTATILETFCRAFLSSLSSTGYYHNS
S*TVVTSMFFLFPL*PAADSKPCVT*PRCKRQG
KRDRGYSINYIFSWLWVVPPKIIGPVKTSVCVCV
CVCVCVVFFFNLYFEFVPQVYLITLVPV*SSYA
EEIHIGCLM*SSAPPYHRPCLVYLGSGKEPSVG
GS*QPLVEGGCP*MY*NYHPKKV*KQGKVVSCLP
GQ*TESTLENRT*AKQTILDTEYKTV*FILKVS
KGCLQRRILLLVSRKKMHSEPKQKLPNVIRLRK
VTLGQCISFLLLCDKLPQI*QFKKQYP*QFCSS*
VWHSVAGFSAQGLKG*NKGWQDNIPSWRLWGRI
CF*VHSGCWRNSVLCWLSAGGPSLTSRLPAFLL
MWSPPASNQPSCSFSCFISLSRPPVLGAYD*LKP
TDIF*G*LCDRT*LQEYCLISSYSRVLEISSLK
VGGAFSNSAYHRQ*LPISAVGGIFTQKR*ALEA
SFLFSMEKDSPLLQRSTCVFTDRVNYRNSFSS*R
GLFYILKLFFNKIELCCVLCFLIGNALLDCFCN
ILFIANS*YRSKTV*NTFVHISNV*FVYTSVKF
P*NLKGDLVEIKIYT*SKS

Frame 1

WHWEARPGGGDGVPLAALGFGCSGSAFSSAHGD
PLRLEASQLLPPPRSRWGRRTGRSATSTSRSTG
SRLVALCFSSSQTYVQKHAKTSFACAQERKALGK
QLGRSYVIKVLRSIVWLKTL*FRVGTSVKVMEK
VENQFMVDILKRMWSFAK*KDENFILKHDRAFL
LSMANRGKHTNGSQFFIKSVTPCAPKYHKACSTP
GWGACSLWTGYFWF*SNRTN*KSEDRCCKQTIC
RCASY*LWSTCHKINKRCF*EKKEETNSFRRLG
FLFQFLLFFRIIFRK*T*T*EKQKEET*EEAKS*
TF*KEAKGSKQFRRAKE*TCNEPKRSL*EE*YQ
*KKVS*FQC*KGKTCGPPRRDSSSA*EPIFTEK
RYACCYCRT*TEDS*CCTHCK*SETICIKVWTED
*RKGHNSLSHTSKIKILF*VR***QQ*NSSSLE
RGNAEIKSI*TT*WRKME*RR*VK*PLFKPMG*
KKLVSEIQIMVL*WILFRP*YSKTLWPP*KTQKR
KKG*A*KEREKAETLQKTQTNKEEKDSYTV*HR
ILKIFHSKNEILL**RKEFSFFLIVISSLIKER
LV*I**GCPELFNPFQQRLIQIKISLTVLF*RKL
KIKDCVKVLITFSK*IKVQI*FQVWAPKESIKI
TKKNSFSVK*K*TS*NRTFKSNHGTK*KCSSTT
SCSRKYSCNTTE*QSPPFKMEAWTETLEALL*AN
SGNES*NNPFATHPKHLQFSKY*RDW*LIILP*
KRKKFGK*SEHLFKIQ**KFRKLTKVKEQIF*E
*ILFQIIYKIT*SS*FTFKV*VSII*ISFTK*IQ
*SFTV**IIFIYFY*Q**WKAS*EET*IQWEKK
*RFT*KA*QQL*KDTSQ*ICQR*RQVFMCEKV*
REQIIFRLFFRQ*AVKCSGHTVSPGKREAGPNGK
NT**TRKKQR*RKIQV*TGMPSFKKKNFERESF
*SP*KWQ*AQKEELCW**MGL*VKFRTRCH*KQ
*K*LPSIL*QGRR*GHIRF*IRG**NSHQSQTHN
QVVHKYFTA***WCLEIKQTAHINF*L*GVLFQ
FGKQ*GKATKAQTWVKGKS*KRTHQKSEREIER
EKRQKA*GSKTKASISLAASTRIW*RGGGGD**Q
ASYSGIKREKSF*KQ*NHKR*YSKN*EIQ*RGP
FR*T*YSDCFIRS*SVY*R***TQYFSHSFKY*
GKCGLFTKHSAR*RKCSQWSGRCASNR*QHGDLH
S**EFPSKSRGDFPSRKCTA*YPRYKHCFEAGY
GNGTSSSRGSKTGKQHVRK*SVG*SGETGQQLC
*LG*CWRKYREEGGG*EEPDQPH**EMEAPARCG
EPGST*CCHIQCCGS*GVDHCA*NETTRLENRN
*KQK*SSAWVSL**SKKDSTLKP*TKKSGEFK*
*ADA*SG***PVQESK*ISK*I*NQIKTQNKVCL
L*SLKKSIEKFHIILSIKKLL*KSEQRMVQQRP
NQKPEQFLPELQKSQDVQQEQIQEQLI*SPQSI
QVLHLR*LL*QESESK*KPEK*QLPPRQKL*SAV
QEL*ILWL*Q*K*PKLLSSPEPQ*EQQIQLKTS
GYKLYLICKYLAT*LKKCNDSLLFYFNIRGEFQ
K*TLLNCYWFIYMWGEEFKIQICLLKIFLCHILQ
*PTMEMNFIFLNQEIVKFIYV*FAILF*VYFTL
SYVSLRIQILFACFSSFSIYAAKHRTVKENC*R
RPNIYILIT*SLVHMCSKNKPPRIDTVGNQEYKA
VALGFLIHS*LL*YFTGLGKWSSYIPHSLYYFR
LVGKVRKNQSALTINTCTVSEDLLFYVLFNQYR
SEV*VIKTILLHALVLGNFWCVFKHYSYISYIKI
P*K*NSDKITGTKNGLF*AVFTLTIWGASLKYR
CGLGSPGAGRIGSKRYWPLKSTVCVCLWKSEEW
TSKVTSKI*LPPSWRHFAGLSFQVFQVQDITTTA
AELL*PACFSYFHCDLQLTQSLA*PDPGARDRG
RGIEGIA*ITYFHGFGWFLQK*LDL*KLVCVCV
CVCVCVWFFFLIFTLNLFPKCT*SP*CQFNPVMQ
KKFILVA*CRAQHHPTTGLVWCIWEVEKSPQLE
GADNPWWREGALECIKTITQRRYENRVRWSVVC
QVNRQKVH*KTGLRPNKQYWILNTKQYDLY*RFP
KVACKGEYYY*SAGKKCIQNPSRNCQM*LG*EK
LPLGSVLVFYCCVTNYPKFSSLKNNTHSSSVAH
ESGTVWLDSLLRVLKAEIRVGRTTFLHGGSGEES
ASKFIQVVGGIQFFAGSQLEAPLSPQGCLHSFL
CGPLQLQTSLPALSHASYLSPVLLF*GHMISSS
PQIYFKVDCAIEHNCRSTVSSHHIHGFWRLAH*K
WEGHFQILPTTGNNCPSQL*VEFLPRKDRP*KP
HFFSPWKRTALCCSVQLVCLLTE*TTEIAFLPK
GDCSTF*SYFLIKLNYVVYCAS**EMHYWTVFVT
SCLLQIASIVQKLYKILLYILAMSNLYTLQLNF
PKT*KGTL*KLKYILSLSL

Frame 2

GIGRPGLGEETAFR*RRWGLAAVAVLSLLLTGT
RSGWRPASSCRHLGRDGGAGPAAVPLRHRDQPG
AGWSHYVSALLRHMSKNMQKLPLLVLRRERPWE
NNWEEVML*RFYVPSCG*KLYDSGWGLQ*R*WKR
WRINLWWIF*RECGLLQNEKMKTLFSNMTERSF
YQWQIEGNIPMVPSFS*RVLHRALQSTTKPAPH
LDGVHVVFGLVISGFEVIEQIENLKTDAASRPYA
DVRVIDCGVLATKSIKDVFEKKRKKPTHSEGSD
SSSNSSSSSESSSESELEHERSRRRKHKRRPKV
KRSKKRRKEASSSEEPRNKHAMNPKGHSERSDTN
EKRSVDSSAKREKPVVRPEEIPPVPENRFLLRR
DMPVVTAEPEPKIPDVAPIVSDQKPSVSKSGRK
IKGRGTIRYHTPPRSRSCSESDDDDSSETPPHWK
EEMQRLRAYRPPSGEKWSKGDKLSDPCSSRWDE
RSLSQRSRSWSYNGYYSDLSTARHSGHHKKRRK
EKKVKHKKKGKKQKHCRRHKQTKKRRILIPSDIE
SSKSSTRRMKSSCDRERSSRSSSLSSHHSSKRD
WSKSDKDVQSSLTHSSRDSYRSKSHSQSYSRGS
SRSRTASKSSSHSRSRSKSRSSSKSGHRKRASKS
PRKTASQLSENKPVKTEPLRATMAQNENVVVQP
VVAENIPVIPLSDSPPPSRWKPGQKPWKPSYER
IQEMKAKTTHLLPIQSTYSLANIKETGSSSSYHK
REKNSESDQSTYSKYSDRSSESSPRSRSRSSRS
RSYSRSYTRSRSLASSHSRSRSPSSRSHSRNKY
SDHSQCSRSSSYTSISSDDGRRAKRRLRSSGKKN
SVSHKKHSSSSEKTLHSKYVKGRDRSSCVRKYS
ESRSSLDYSSDSEQSSVQATQSAQEKEKQGQME
RTHNKQEKNRGEEKSKSERECPHSKKRTLKENLS
DHLRNGSKPKRKNYAGSKWDSESNSERDVTKNS
KNDSHPSSDKEEGEATSDSESEVSEIHIKVKPT
TKSSTNTSLPDDNGAWKSSKQRTSTSDSEGSCSN
SENNRGKPQKHKHGSKENLKREHTKKVKEKLKG
KKDKKHKAPKRKQAFHWQPPLEFGEEEEEEIDD
KQVTQESKEKKVSENNETIKDNILKTEKSSEEDL
SGKHDTVTVSSDLDQFTKDDSKLSISPTALNTE
ENVACLQNIQHVEESVPNGVEDVLQTDDNMEIC
TPDRSSPAKVEETSPLGNARLDTPDINIVLKQDM
ATEHPQAEVVKQESSMSESKVLGEVGKQDSSSA
SLASAGESTGKKEVAEKSQINLIDKKWKPLQGV
GNLAAPNAATSSAVEVKVLTTVPEMKPQGLRIEI
KSKNKVRPGSLFDEVRKTARLNRRPRNQESSSD
EQTPSRDDDSQSRSPSRSRSKSETKSRHRTRSV
SYSHSRSRSRSSTSSYRSRSYSRSRSRGWYSRGR
TRSRSSSYRSYKSHRTSSRSRSRSSSYDPHSRS
RSYTYDSYYSRSRSRSRSQRSDSYHRGRSYNRR
SRSCRSYGSDSESDRSYSHHRSPSESSRYS*KRP
DTNYILFVNIWQLSLRNVMTVCCSISISEVNFK
NRHFLIVTGSFTCGEKNLKYRYVS*KYFYATFY
SSQLWK*ISFS*IKKS*NLSMYNLQYYFKSISLY
LTYPLEYRFFLPVFPVLAYMLPSIEL*RRTVKG
GQIFIY*LHRVLYICALKTNHPELILLVTRSIR
QWLWGS*FIPNFFDTSQD*ESGHHTSHTVCITSG
LWARLGRINQP*L*IPALSLRTYYFMFFLINTD
QKFRL*KQFYFMLWCLVIFGASLSITLIYHILK
YHKNEIQTKSLAPKMVYSELSSL*LFGGLLSSTD
VGWGPLEQAGLAVRDIGHSSLLCVCASGRVKNG
LQK*HQKSNCHHPGDILQGFPFKSFKYRILPQQ
QLNCCNQHVFPISTVTCS*LKALRDLTQVQETGE
EG*RV*HKLHIFMALGGSSKNNWTCKN*CVCVC
VCVCVCGFFF*SLL*ICSPSVLNHLSASLIQLC
RRNSYWLPDVELSTTLPQALSGVFGKWKRALSWR
ELTTLGGGRVPLNVLKLSPKEGMKTG*GGQLFA
RSIDRKYIRKQDLGQTNNTGY*IQNSMIYIKGF
QRLPAKENITTSQQEKNAFRTQAETAKCN*VKKS
YPWAVY*FSIAV*QITPNLAV*KTIPIAVL*LM
SLAQCGWILCSGS*RLK*GLAGQHSFMEALGKN
LLLSSFRLLAEFSSLLALSWRPLSHLKAACIPSY
VVPSSFKPAFLLFLMLHISLPSSCFRGI*LAQA
HRYILRLIVR*NIIAGVLSHLIIFTGSGD*LIE
SGRGIFKFCLPQAITAHLSCRWNFYPEKIGPRSL
ISFLHGKGQPSAAAFNLCVY*QSELQK*LFFLK
GIVLHFEVIF**N*IMLCIVLLNRKCIIGLFL*
HPVYCK*LVSFKNCIKYFCTY*QCLICIHFS*IS
LKLERGPCRN*NIYLV*V*

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