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Sequence NM_001003675
GGAACATTGAGCATCCTGACTTTGAAGGAGTCTCTGTGGTGTTTTTGTGCTACCATACATGGGGAATAATGATGTGAGGCAGAGGGAGAGGGAATGAATGGGAGAGCCAAGAGGGAAGAGCGAGCCGGGGGGAAAGGAGCGCGCAGTGTTTCCTGCTGCGGTTAGGACCTCACGCCTTGCCAGTACAGAGCTCGGTGGCA
AGAGCCGCTGGGAGCTGCTCCCATCAGTTAGAGGATGTGGAGAGGGAGCACCAGAAGAGGACAGCCCGCAGCCTGGCTCGCAGCCTGAGGGACGCTGTGG
GTGCTCCCAGCCGGGCGAGCACGCTCTGGGAGCGGATCTGCAGGGGAGAAGCACGCGAGCCTAACGTGAGCGTCCCGCCTGTCGCGTGTCCTGCCTTGGT
AAGCGCCCTCTCCGGTCCTTCCACACTGAAAGCTTCCAGCAGAGATCAAGGGAAGGAGTATTGTGTGAGACTTGCAGATTTCCTCCTTTCTGTCTGGACT
GGTTTGATATTTGCCTGTTGAAAAGATTACTGAACGCAGTGTGACAAGATGAGCCGTCTAGCTGCGTTCTGCTTGCCTGTGTGTGTGACACGTCCAGGTG
TGAGGCCAAACCTGAGAAGTGCAGACTGCTCACTGATAGACGTTGCTGTAAACAGTAGTGCCCTGGGTGTACAGCTGGTCTCAGGATCGGAGACCCCGGA
CTTATTCTCTGCTCGGTGACACGGCCGGCTTCCTGCCGCAGAGCTCCTGGTTTCTGTTGATGGCAGTTGATAATTGGTAGCCACAGTCTGCGGTCGGAGC
CACAGCATTTGAGTCTAGCACCTGGGGTGGGCCCTGCTGATACAGTAGAGAGAGAGTGAACGAGGCAGACAGAAACACACCCCCCCCCCCTCCACGCTCA
CACACTCTCCCACACCCCATGCCAGCTATAACTGCAGCTCTGAGCTGCCTGGAGAGGAGATTGCCGGAAGCTGAAGGGATGCTTTGAACGTGGGGGGGCT
GCGTCACAGTTGGACTCCCACTTGCAGAGGACCTGATTATGTCCAGTGACCACCTGAACAACAGCACACTGAAGGAGGCTCAGTTCAAAGACCTGTTCTT
AAAAAAAGCGGAGCTGGAGTTCGCCCAAATCATCATCATCGTCGTGGTGGTCACGGTGATGGTGGTGGTCATCGTCTGCCTGCTGAACCACTACAAAGTC
TCCACGCGGTCCTTCATCAACCGCCCGAACCAGAGCCGGAGGCGGGAGGACGGGCTGCCGCAGATCATGCATGCCCCGCGGTCCAGGGACAGGTTCACAG
CGCCGTCCTTCATCCAGAGGGATCGCTTCAGCCGCTTCCAGCCCACCTACCCCTATGTGCAGCACGAGATTGATCTTCCTCCCACCATCTCCCTGTCCGA
CGGTGAAGAGCCACCTCCTTACCAGGGGCCCTGCACCCTGCAGCTCCGGGACCCTGAACAGCAGATGGAACTCAACCGAGAGTCCGTGAGGGCCCCACCC
AACCGAACCATATTTGACAGTGATTTAATAGACATTGCTATGTATAGCGGGGGTCCATGCCCACCCAGCAGCAACTCGGGCATCAGTGCAAGCACCTGCA
GCAGTAACGGGAGGATGGAGGGGCCACCCCCCACATACAGCGAGGTGATGGGCCACCACCCAGGCGCCTCTTTCCTCCATCACCAGCGCAGCAACGCACA
CAGGGGCAGCAGACTGCAGTTTCAGCAGAACAATGCAGAGAGCACAATAGTACCCATCAAAGGCAAAGATAGGAAGCCTGGGAACCTGGTCTGATTCCTT
CCAACGTGCACTTCAGCTGGAGAAAGAAACCAAGAAGGGAAGCGGCCGCTGGGCCCCTCCTGCGCACAGTGTTGTTCAGTTTCACATGGTACAAATAAGT
AAAACCAAATGAGCAAACACGGTCTTTGTTTCTGATTCCTTTTAGGGGAATTGCATGCAAACTAGACTGAAATGATACAAACTTCCATCTGGTCTGACCG
CAAACAGTGTTTATTTGGGGACAGGGGTTGGGATGGGGGTGTGGGCAGGGGAAAACAGAGAACGGGATGCTTTGAAGATACCATGAAATAAAACCCACAG
AGGTATTTGATGTATTTAATTGTGAAAGGAGACTTTGCAGATAAATGAGGCCAGAATGGCATGTTTTATAATTAACTGAATAAAGAAGGAAGCATTATTA
TATATTATTGTGGGGAAGAACCAGCCAGTTCGCTTTTTCTCCTAAGGTGTGGAACTTTTATTTTGTTTTAAAAATATGAATCAAAATTCCTGTGTTGTGT
GCCAAGGTATAAAGTGGAGAAGTTAGATGAGTGCAAGGAGCTCCTTTGTGTTGTGATGATGTGTTTTAAAAGTTGCACTATCTTAATGTTGAAAATATTT
ACAAGGGAACTGTTTTACGTGAAGTTCTGTATGTTGTCTTTTCACCTGTGGATTGTAATCAGGCCCAAGGAATATCCTGGAGTGGTCCCCAGAAGCATCC
AAGAAAAGATATTTGGGGACGTAGCCTAACATTTTACCAACTTACGTAAATCAAAAAAGTCATTATTGTTGCAGGAGTTTGCATCAAATAGCAGTGCATC
GCTGAAGCTTTTGGAGACTTTTGGATGGAAGATAAGATAGGGAAGATTAAGTTCCAGCATTTCTGACTTGTTATTTTGAGTTACTCTGCTACTCTTAGGC
TGCATAGTTTATGAGAAAATGAACACATGCATTTATGGATCCAGTATCATGCAGTGCTGCCCTCATCCTCCAGCAGTGCAATTTCTTCAGTAATTTAGAT
TTTTTTCACTATAGCATGAAATATATTCAAATACATACCTTATTTTATGCAATAAATTGTTTAAAATGCAAGGTGGTTATTCTGCATACTGTTGAAATAT
GTGACTCCTCAGTATATTCCCATTGCCTCTCCCCCTTTCCTCGACAGCTTAGTTCAGTTCTGCAGGGCTGCTCAGTTCACAGGAGGCTCCCAGCAGCCAC
CCCACATCCAGCCTACACAGAACTTCGTGTGGGAGTGGTGTGGGTGGTGGTTTCTTATGCTTTGGAAGCCCCTAGAAATAATGACGGAAGAATGCCATGT
TGCTGATCGTGGTAATAAGCCATTGTGGGTTATTGTATGTCACTAGTATTAGCATAGCATTCTTAAAGGAATGCAGTGCTCAAAACCTACCCAAATTCCC
GCAGGATTCTACCAAACCCTTCCCCAGGCCAGCTTTTGTACTGAAGGCAAGAACTGGACAGTCAGAGAACAGTGGAGGGGGCAAGTGACTGAAGAGCACC
GGGTAAAAAGCACAACATGCAGTTAAAATGCAACTAGAAAACTAATTTTAAATATTGTTAGTTTTAATATTCCTGATATTTACAAATATTCATTCTTATA
TACAATGAAAAAAATAACTTTCTTCTGCAGATGTAAGCACTGGCTTTTATAAGAGCAGCAGCCAACACGTTTAGCAGACACTGCGCGTGGAGAAGGGCTT
ATCTGCAGTACACTCTGCCATGTGGAGGGTGGGCCTCTGTGGCCTCTTCACATAACAAGATGAGCTGGAATGATGATTCCATGACTCCCACCTATGCAGC
CTTAAAGCCAAATCCGCGTGTGTGTGTTTGTGTCTGTCTGTGGGTCTCGAAGGTGATCCGTCGGTGCGGTGGCTCTGTGCTGTAACTGGAGAGACTGTTC
CAAACCCCAAGAGTTGTCTGATCCTAGTCTGTTCCCTTCTGCTTCTTACCTCTGTAGATAGGTCACTGGTTTTTGTTTGTTTGTTTTGAGGATTGGAATT
TCCATTACATTCATCCTTTGCACACAGTAACATCCACAGAACTAGTCCAACTCTTAAAAGGAGAGAGGAAAAACACAGGCACCAGTTGTCAGCTCATGCT
TACAACCTGTGTGGAAGTATATACAGTTGAGAGTCACAGTGGAGGTTCTGAGACTGGATTCAGTCTTGTTCCAGTGACAGTTGGAAGGCCTCTGCTGGAG
AGACACCAGCTCTCAGGGCAGAGATTGGCTTGGGGCCAGAAGGACCCTCCCCAACCCTGGAGACACCCTGAAGGTTCACTGGCTCTCCAGATTAGCCTCT
CTTCCTCTGTCAGGCAAAGATGAGGAGCCCGTGTTCCCATCGGGCCCTGCTGGCAGGGACTTGCAGTGGATTCTTGGTCAGGTGTGCCCACAGATGCGGA
GGCGAGGTGAGTGATTCCATCATTTCAGTTCTCACCTGCAGTTTTGGTGAAGCAGGAGATGCACCCCACAGCTCTAGCTCTCAAATGGCTTCACAGTCCT
TACTTCTCTACCTGCCTCAAGAAGGGGCTCAGAGCAGAGACTTGTGAATTCCTTAGTAACTGTGAGTATATGAATGTGTTGCACATGTCCACAGTATTGG
CGAGATAATTACATAATTCAGATACCTTTAATCATCTTTCAAGAAAGAGGCTCCTCCCATTCAACCACCCTAGAGAACTGCCTTTGTTAAATAGTTATTT
AAAGACTCATACATATCAAACCATGACTTTGAAAGGTCTTCGAGGCTGGGGCTCTGTAATGAATTAGTTTAAAAGCCAAGGTCATAACATGAATTGATGG
TCAATTTCCCTTCAGCAGAAGGAAAAGGTGATTTAGATCAGTAGCTCTTTTGAAGGTTGTGGCTGACCTGTTCATACCGTGTCGCCTCATGGCTAGTGTG
GCGTTGAAAGAGTAGCGACTGGGAAGATACAACTTACACAGTGGGGCCTATTGTTCTTTCAAGAACCCTTTTTTTAGCTTATAGAACCCATGGGTCCAGT
TTAGTAACGAGTGATTTAGGCAATCAATGATAGGTTTATAATCTTAGATTATTCCAGCAAAGTGTGGATTGCATTGTTAGGAAGAACATTTGGTGGGAAT
GAACACTCCTGGGCATACCGCTGACTTTTGTCCCTTGTTCCCGGTGTAGGAGACCCAAGGCATCTTGAATCCCATCTATAAGAACACAATCTTCCAGCAT
ACGTTTGCTTTTTCAGAAACTCTAGCATTCTCTTTAAATACTGACGCAATCCTTAATGGAAAAGAGATTTCATGAAGCAAATTATGTATTTCAATAGTTC
TTCTATTTTTAGTGTCCAAAATTTACTAATACAGAAGCTTGACAAGCATGTCCTCACCCTCCCCACCACATAAACACATGGACACACACCCAAGCCACAA
GAAATCCCAAGAGAGCAGAAGCGAATTTTTAAAAGATTTATCGTGAGGACTGCATTTCCATTCACTAATTTTGGCTCAAACTTATGAGGCAGGAAATAGG
GGCCAACAGTAAATGGGGGAGGCCTCCTGACACCAGCAGAGGAATTTTGTACCCAGGCGAGGACTTCTTGAACTTCTGCGTATCTCCGTTTGATCTCTTT
CACCTTTATTTCATCTTCATAAGAATGAGAAAGGCTCAAAAGGAAGCACTTTTAGAAATCTTCTCTGACCTAGAAGAATCCATCCAAATCCCTGCCTTCC
TCTCTGAACCAACAGTTCCCTTCTCTGACAGGGGCCATCCTCTATCTTCCATCCAGCGGCTCTTCTTTTTAGGAAGGCTCTGGTGCAGAGCACTTCAAAT
ATGTCCTCAGGCCAGATACTGATTGCTAGTAGAGAGACACCCGGCACCCAGTCCGAAGCCCTCCCTCAAAGGACCGGCTCATGGCGTTGGTCACTGGCAG
GCTCAGAGACATTCTGCTGTGGGCGCAGGGAGCCCGGCCCCCCATGCAGCCATGACTGGATGCGCCCCCATCTCGGGGGCTTGCTGCACTGCTTGTTTAT
TGAATTTTGCTACTTAGAATGGCAACATTAACTTTGTGTACCATTCATTTTTTAAAAATTTTCCAAAGCTCGGCAGTGTATGAAAGAAAAAACTGGGAAA
GATACTTGGTTTCTGTTAACTTTTGTGTTGCTTGCTTAAGTGATTAAAGCCAGTGCTTGGAGCCAAGCCTTCATGCCACGAACATGCTCCACAGCCTGCC
CTTTGCTCTCCTGCTCACACTGACCAAGAATGCCGCGTGCTTGGCCTACTGAGGTGAAAGGACAATTGAATGACAGGTGGGCAAAGGGAGAACTTCCCCT
TCTTGGTGCGAGGAAAGTCACAAATTTAAAAATGTTGCTTCCAGCCCAGATCCTAAATGCTAGTTCTCAGCAGCTGCGTGGCTTACCGTTCGCCATTTCC
ACCACCGCCAGCTGCCAGCACCGCTACAGATCACAGAGATGTGAACAGACAATGGAAAGCACTCTTAGCCTTGCAGTGGTCTACATTTTTTAGGAACCAA
TATTTCAGCATTCTTTATTACCCGGCACGCTGTGTCCTTTGCAGAGTTCAAGTTTATGTTACTGCCAGGGTCAGACAGTCATTTGCTGCTGCTGCTGCTG
CTGCTGCTTCTCGAACTGGATGCATTAGGAAGCTGCTGTCTGAGTGTAGGAATGTCTTGCTAAGAAAGCAATGTCTTCCTTCATCCTTTTCTTTCTTCCC
TCTGCGTGTCCTTGTTTTTGTGTAATGCGGGAGAGGGTTAGAGCTATAGAGATTATATATACACTATCCGTGCACATTATATATATGTAGATATACCCCT
ATCATGTCAGAGATCTGCATGTCAGTTTTTCAGCAACTAAGGTGCCTCATGTTCTGAGTTCAGCAGATATAGGAACCAAGCCGCCCCCTCCTGCACTTGA
TGCTCCCACCTTTGTTGTGCCTCACTTAAAATGGTGCTTTTTTCAGTTGTCTGTCTTTTCTTATGTTTTTATTTGTAAGGTGCTGTATATAAGTTGAATA
TATTATGCACATATCCTACCCAATGGGTAGAACAAAAAGTTGTTAATACTGTAATATAATGTATAGATGATACCAATTTTAACAGAAATGGCATAGAATT
TGTGAATGCCTATGTGCTTTGTCCTCTTTTGTAAGGAAATTTGCAAATGGATGCATACAGATTAAAGTCTATGTAGTTTATTTTCCTATTAAATATCAAT
ATTATAACACAAGAGAAAGAAGTGTGAACAAACAAGCAACAGTTTATGACCAGCGTATATATAGCAATGGAAAGTTGCATCTTTGCTGTGAAAACACTTT
AAAGAAAATACTTTTTAAAAAATCCCACAGCTTTTTGGTTGCCACTAGACGCTTCTTATTTTAATCATTTTAGTAATGCTCAGCTGGACCAGTGTTAGTT
ATATTTGAGTCAGAAAAATGTTGTTTTTCAACTTGCTTTATAATCTCCTGCATCTATCTCCTGCTGTAGCATCACGAAGGTGTCAGGCAACAGTGAAAAG
TGCACATTTTTGTTGTTGCAGAAACTGTGTCAGAGGAATAAGTAAATCAGCCTGCAGCAGAAGACTTTGTTCAGCTCCAGAGGCATCTGTGACCGTCTGT
GTCCAAGTCTCTCTGTGCCTTTTTCTTTTACAAACTGAAGCTGTGGAGCCAATGAAGTAACAGTAGAGATTGTAGGGAAAGAATACCTCAGGAAAAACAA
ATACACTTACAAGAAGACCCTGTTCTTAGAAAATGTGTTTAGTTATGGGTTAGCACTAGAAGAGACTTGGCTGTCAGCCAGCCAAGTGAAGGACCTCTCA
TCCATTCCCATTCATGTCCCATCATAATACGGACCCAAAAAGCAAACTCGGTTTTGCCATCAGTTAGAAATTACGTTTTGGATTGTATATTGTTACATCT
CTCTTCCGGCTTAGTTTTTAGTGTCTGATTGTGACCTCTGCATTTATCTTCAAATACCCTAATTTTAAAACAAAAGAACAAGAAAAGTTTATAACACCAT
GTTCACTAAAACCACGGTTGAATCTTGGGTGTGGGCATCCTTTCGAGTGTTGTCCATAAGAGCAGTTCGTGGAATTTTGCCCATCTGACCCATATTATCA
GCTTATTCTGCCACCAGAGTAGAGTCTAATAAATTCCAAAGTTTTTATTTGCTCCATGGTGTATGTTCTGACTTTGAAAATGTCAGATTCTATAATCATA
CCCCTAACATCCAGGAAACAAATGACAGATTATCTTTAAACTGAAATTGACTCTACAATGCAACCCTTAATGCTGAATGGATTAAAAAAGTCAGCCCTTT
TAGTATCTGTTTGAAAGGGCCGTAAAAAGTTGACACTTTTGTTGTTGTGGATCCTGCGTGTCTAGACCCACGTGTTGTTTCCATCGTATACTGTAGGGTG
CACCCCTTGGGATTCATCATTAAGAACTGAGGCTCACTGTTGTCAGAAACAAAGCTCCCACCCCCCAGGTTCAACCTTGTGGGAGAACTGTTGAGCATGA
GAATGTTCTAGACTCAGAGGTACTAAAATTTGTTACCACATCATTGCTTCCTTTCTACAGGACGAATTGAGGCTTAAACTTTACTGTTAATGATACTGGT
TCATTTTAATGTGCTTGTTGGTATGTTGCTATTTTTCATTTCATAGCTTTCAAAAATCATGCTAATTGTATACTTGTCTAGTTTAAGGCTATTTTAAAAT
ATGTACAATACTATTCACAGCATTTAGTTCGTTTAATTTTTATTATAAAGCAATCTACTAAAAAAGTACAACTGTATTTGAACTTTTCAATAGTTGTTTG
TGAGCTATGATAATCAAAAGTCATTAAAGTCTTTTTTAACAAACATTCGTGCTTACTTTTCAACATAATTCCCAGTTATATACAGAAAAAGATTTCCACC
TGTCACGTATCTGCCTCTTTTACCTGAGCAATGGTGTAGTTCTTAGACCTAAGGTCTGTAATTGCAATACTTTTAAAGAAAGATGTTGCTCTAAGTGCTG
TTTGTTAGTTATGAAATCAGATTTTTCTGCTTGTTCTTAATGCTGTGGTCAAACCATAGCACAAAATCATTAAAAATAATCAGCGGCATAC
- refseq_C18orf1.F1 (forward primer)
- refseq_C18orf1.R1 (reverse primer)
- Single exon skipping
Frame 0
GTLSILTLKESLWCFCATIHGE**CEAEGEGMNGRAKREERAGGKGARSVSCCG*DLTPCQYRARWQ
EPLGAAPIS*RMWRGSTRRGQPAAWLAA*GTLW
VLPAGRARSGSGSAGEKHASLT*ASRLSRVLPW
*APSPVLPH*KLPAEIKGRSIV*DLQISSFLSGL
V*YLPVEKITERSVTR*AV*LRSACLCV*HVQV
*GQT*EVQTAH**TLL*TVVPWVYSWSQDRRPR
TYSLLGDTAGFLPQSSWFLLMAVDNW*PQSAVGA
TAFESSTWGGPC*YSRERVNEADRNTPPPPPRS
HTLPHPMPAITAALSCLERRLPEAEGML*TWGG
CVTVGLPLAEDLIMSSDHLNNSTLKEAQFKDLFL
KKAELEFAQIIIIVVVVTVMVVVIVCLLNHYKV
STRSFINRPNQSRRREDGLPQIMHAPRSRDRFT
APSFIQRDRFSRFQPTYPYVQHEIDLPPTISLSD
GEEPPPYQGPCTLQLRDPEQQMELNRESVRAPP
NRTIFDSDLIDIAMYSGGPCPPSSNSGISASTC
SSNGRMEGPPPTYSEVMGHHPGASFLHHQRSNAH
RGSRLQFQQNNAESTIVPIKGKDRKPGNLV*FL
PTCTSAGERNQEGKRPLGPSCAQCCSVSHGTNK
*NQMSKHGLCF*FLLGELHAN*TEMIQTSIWSDR
KQCLFGDRGWDGGVGRGKQRTGCFEDTMK*NPQ
RYLMYLIVKGDFADK*GQNGMFYN*LNKEGSII
IYYCGEEPASSLFLLRCGTFILF*KYESKFLCCV
PRYKVEKLDECKELLCVVMMCFKSCTILMLKIF
TRELFYVKFCMLSFHLWIVIRPKEYPGVVPRSI
QEKIFGDVA*HFTNLRKSKKSLLLQEFASNSSAS
LKLLETFGWKIR*GRLSSSISDLLF*VTLLLLG
CIVYEKMNTCIYGSSIMQCCPHPPAVQFLQ*FR
FFSL*HEIYSNTYLILCNKLFKMQGGYSAYC*NM
*LLSIFPLPLPLSSTA*FSSAGLLSSQEAPSSH
PTSSLHRTSCGSGVGGGFLCFGSP*K**RKNAM
LLIVVISHCGLLYVTSISIAFLKECSAQNLPKFP
QDSTKPFPRPAFVLKARTGQSENSGGGK*LKST
G*KAQHAVKMQLEN*F*ILLVLIFLIFTNIHSY
IQ*KK*LSSADVSTGFYKSSSQHV*QTLRVEKGL
SAVHSAMWRVGLCGLFT*QDELE**FHDSHLCS
LKAKSACVCLCLSVGLEGDPSVRWLCAVTGETV
PNPKSCLILVCSLLLLTSVDRSLVFVCLF*GLEF
PLHSSFAHSNIHRTSPTLKRREEKHRHQLSAHA
YNLCGSIYS*ESQWRF*DWIQSCSSDSWKASAG
ETPALRAEIGLGPEGPSPTLETP*RFTGSPD*PL
FLCQAKMRSPCSHRALLAGTCSGFLVRCAHRCG
GEVSDSIISVLTCSFGEAGDAPHSSSSQMASQS
LLLYLPQEGAQSRDL*IP**L*VYECVAHVHSIG
EIIT*FRYL*SSFKKEAPPIQPP*RTAFVK*LF
KDSYISNHDFERSSRLGLCNELV*KPRS*HELM
VNFPSAEGKGDLDQ*LF*RLWLTCSYRVASWLVW
R*KSSDWEDTTYTVGPIVLSRTLFLAYRTHGSS
LVTSDLGNQ**VYNLRLFQQSVDCIVRKNIWWE
*TLLGIPLTFVPCSRCRRPKAS*IPSIRTQSSSI
RLLFQKL*HSL*ILTQSLMEKRFHEANYVFQ*F
FYF*CPKFTNTEA*QACPHPPHHINTWTHTQAT
RNPKRAEANF*KIYREDCISIH*FWLKLMRQEIG
ANSKWGRPPDTSRGILYPGEDFLNFCVSPFDLF
HLYFIFIRMRKAQKEALLEIFSDLEESIQIPAF
LSEPTVPFSDRGHPLSSIQRLFFLGRLWCRALQI
CPQARY*LLVERHPAPSPKPSLKGPAHGVGHWQ
AQRHSAVGAGSPAPHAAMTGCAPISGACCTACL
LNFAT*NGNINFVYHSFFKNFPKLGSV*KKKLGK
ILGFC*LLCCLLK*LKPVLGAKPSCHEHAPQPA
LCSPAHTDQECRVLGLLR*KDN*MTGGQRENFP
FLVRGKSQI*KCCFQPRS*MLVLSSCVAYRSPFP
PPPAASTATDHRDVNRQWKALLALQWSTFFRNQ
YFSILYYPARCVLCRVQVYVTARVRQSFAAAAA
AAASRTGCIRKLLSECRNVLLRKQCLPSSFSFFP
LRVLVFV*CGRGLEL*RLYIHYPCTLYICRYTP
IMSEICMSVFQQLRCLMF*VQQI*EPSRPLLHL
MLPPLLCLT*NGAFFSCLSFLMFLFVRCCI*VEY
IMHISYPMGRTKSC*YCNIMYR*YQF*QKWHRI
CECLCALSSFVRKFANGCIQIKVYVVYFPIKYQ
YYNTRERSVNKQATVYDQRIYSNGKLHLCCENTL
KKILFKKSHSFLVATRRFLF*SF**CSAGPVLV
IFESEKCCFSTCFIISCIYLLL*HHEGVRQQ*K
VHIFVVAETVSEE*VNQPAAEDFVQLQRHL*PSV
SKSLCAFFFYKLKLWSQ*SNSRDCRERIPQEKQ
IHLQEDPVLRKCV*LWVSTRRDLAVSQPSEGPL
IHSHSCPIIIRTQKANSVLPSVRNYVLDCILLHL
SSGLVFSV*L*PLHLSSNTLILKQKNKKSL*HH
VH*NHG*ILGVGILSSVVHKSSSWNFAHLTHII
SLFCHQSRV**IPKFLFAPWCMF*L*KCQIL*SY
P*HPGNK*QIIFKLKLTLQCNP*C*MD*KSQPF
*YLFERAVKS*HFCCCGSCVSRPTCCFHRIL*G
APLGIHH*ELRLTVVRNKAPTPQVQPCGRTVEHE
NVLDSEVLKFVTTSLLPFYRTN*GLNFTVNDTG
SF*CACWYVAIFHFIAFKNHANCILV*FKAILK
YVQYYSQHLVRLIFIIKQSTKKVQLYLNFSIVVC
EL**SKVIKVFFNKHSCLLFNIIPSYIQKKIST
CHVSASFT*AMV*FLDLRSVIAILLKKDVALSA
VC*L*NQIFLLVLNAVVKP*HKIIKNNQRH
Frame 1
EH*AS*L*RSLCGVFVLPYMGNNDVRQRERE*MGEPRGKSEPGGKERAVFPAAVRTSRLASTELGG
KSRWELLPSVRGCGEGAPEEDSPQPGSQPEGRCG
CSQPGEHALGADLQGRSTRA*RERPACRVSCLG
KRPLRSFHTESFQQRSREGVLCETCRFPPFCLD
WFDICLLKRLLNAV*QDEPSSCVLLACVCDTSRC
EAKPEKCRLLTDRRCCKQ*CPGCTAGLRIGDPG
LILCSVTRPASCRRAPGFC*WQLIIGSHSLRSE
PQHLSLAPGVGPADTVERE*TRQTETHPPPLHAH
TLSHTPCQL*LQL*AAWRGDCRKLKGCFERGGA
ASQLDSHLQRT*LCPVTT*TTAH*RRLSSKTCS
*KKRSWSSPKSSSSSWWSR*WWWSSSAC*TTTKS
PRGPSSTARTRAGGGRTGCRRSCMPRGPGTGSQ
RRPSSRGIASAASSPPTPMCSTRLIFLPPSPCP
TVKSHLLTRGPAPCSSGTLNSRWNSTESP*GPHP
TEPYLTVI**TLLCIAGVHAHPAATRASVQAPA
AVTGGWRGHPPHTAR*WATTQAPLSSITSAATH
TGAADCSFSRTMQRAQ*YPSKAKIGSLGTWSDSF
QRALQLEKETKKGSGRWAPPAHSVVQFHMVQIS
KTK*ANTVFVSDSF*GNCMQTRLK*YKLPSGLT
ANSVYLGTGVGMGVWAGENRERDALKIP*NKTHR
GI*CI*L*KETLQINEARMACFIIN*IKKEALL
YIIVGKNQPVRFFS*GVELLFCFKNMNQNSCVV
CQGIKWRS*MSARSSFVL**CVLKVALS*C*KYL
QGNCFT*SSVCCLFTCGL*SGPRNILEWSPEAS
KKRYLGT*PNILPTYVNQKSHYCCRSLHQIAVH
R*SFWRLLDGR*DRED*VPAFLTCYFELLCYS*A
A*FMRK*THAFMDPVSCSAALILQQCNFFSNLD
FFHYSMKYIQIHTLFYAINCLKCKVVILHTVEI
CDSSVYSHCLSPFPRQLSSVLQGCSVHRRLPAAT
PHPAYTELRVGVVWVVVSYALEAPRNNDGRMPC
C*SW**AIVGYCMSLVLA*HS*RNAVLKTYPNS
RRILPNPSPGQLLY*RQELDSQRTVEGASD*RAP
GKKHNMQLKCN*KTNFKYC*F*YS*YLQIFILI
YNEKNNFLLQM*ALAFIRAAANTFSRHCAWRRA
YLQYTLPCGGWASVASSHNKMSWNDDSMTPTYAA
LKPNPRVCVCVCLWVSKVIRRCGGSVL*LERLF
QTPRVV*S*SVPFCFLPL*IGHWFLFVCFEDWN
FHYIHPLHTVTSTELVQLLKGERKNTGTSCQLML
TTCVEVYTVESHSGGSETGFSLVPVTVGRPLLE
RHQLSGQRLAWGQKDPPQPWRHPEGSLALQISL
SSSVRQR*GARVPIGPCWQGLAVDSWSGVPTDAE
AR*VIPSFQFSPAVLVKQEMHPTALALKWLHSP
YFSTCLKKGLRAETCEFLSNCEYMNVLHMSTVL
AR*LHNSDTFNHLSRKRLLPFNHPRELPLLNSYL
KTHTYQTMTLKGLRGWGSVMN*FKSQGHNMN*W
SISLQQKEKVI*ISSSFEGCG*PVHTVSPHG*C
GVERVATGKIQLTQWGLLFFQEPFF*LIEPMGPV
**RVI*AINDRFIILDYSSKVWIALLGRTFGGN
EHSWAYR*LLSLVPGVGDPRHLESHL*EHNLPA
YVCFFRNSSILFKY*RNP*WKRDFMKQIMYFNSS
SIFSVQNLLIQKLDKHVLTLPTT*THGHTPKPQ
EIPREQKRIFKRFIVRTAFPFTNFGSNL*GRK*
GPTVNGGGLLTPAEEFCTQARTS*TSAYLRLISF
TFISSS*E*ERLKRKHF*KSSLT*KNPSKSLPS
SLNQQFPSLTGAILYLPSSGSSF*EGSGAEHFK
YVLRPDTDC**RDTRHPVRSPPSKDRLMALVTGR
LRDILLWAQGARPPMQP*LDAPPSRGLAALLVY
*ILLLRMATLTLCTIHFLKIFQSSAVYERKNWE
RYLVSVNFCVACLSD*SQCLEPSLHATNMLHSLP
FALLLTLTKNAACLAY*GERTIE*QVGKGRTSP
SWCEESHKFKNVASSPDPKC*FSAAAWLTVRHF
HHRQLPAPLQITEM*TDNGKHS*PCSGLHFLGTN
ISAFFITRHAVSFAEFKFMLLPGSDSHLLLLLL
LLLLELDALGSCCLSVGMSC*ESNVFLHPFLSS
LCVSLFLCNAGEG*SYRDYIYTIRAHYIYVDIPL
SCQRSACQFFSN*GASCSEFSRYRNQAAPSCT*
CSHLCCASLKMVLFSVVCLFLCFYL*GAVYKLN
ILCTYPTQWVEQKVVNTVI*CIDDTNFNRNGIEF
VNAYVLCPLL*GNLQMDAYRLKSM*FIFLLNIN
IITQEKEV*TNKQQFMTSVYIAMESCIFAVKTL
*RKYFLKNPTAFWLPLDASYFNHFSNAQLDQC*L
YLSQKNVVFQLAL*SPASISCCSITKVSGNSEK
CTFLLLQKLCQRNK*ISLQQKTLFSSRGICDRL
CPSLSVPFSFTN*SCGANEVTVEIVGKEYLRKNK
YTYKKTLFLENVFSYGLALEETWLSASQVKDLS
SIPIHVPS*YGPKKQTRFCHQLEITFWIVYCYI
SLPA*FLVSDCDLCIYLQIP*F*NKRTRKVYNTM
FTKTTVESWVWASFRVLSIRAVRGILPI*PILS
AYSATRVESNKFQSFYLLHGVCSDFENVRFYNH
TPNIQETNDRLSLN*N*LYNATLNAEWIKKVSPF
SICLKGP*KVDTFVVVDPACLDPRVVSIVYCRV
HPLGFIIKN*GSLLSETKLPPPRFNLVGELLSM
RMF*TQRY*NLLPHHCFLSTGRIEA*TLLLMILV
HFNVLVGMLLFFIS*LSKIMLIVYLSSLRLF*N
MYNTIHSI*FV*FLL*SNLLKKYNCI*TFQ*LF
VSYDNQKSLKSFLTNIRAYFST*FPVIYRKRFPP
VTYLPLLPEQWCSS*T*GL*LQYF*RKMLL*VL
FVSYEIRFFCLFLMLWSNHSTKSLKIISGI
Frame 2
NIEHPDFEGVSVVFLCYHTWGIMM*GRGRGNEWESQEGRASRGERSAQCFLLRLGPHALPVQSSVA
RAAGSCSHQLEDVEREHQKRTARSLARSLRDAV
GAPSRASTLWERICRGEAREPNVSVPPVACPALV
SALSGPSTLKASSRDQGKEYCVRLADFLLSVWT
GLIFAC*KDY*TQCDKMSRLAAFCLPVCVTRPG
VRPNLRSADCSLIDVAVNSSALGVQLVSGSETPD
LFSAR*HGRLPAAELLVSVDGS**LVATVCGRS
HSI*V*HLGWALLIQ*RESERGRQKHTPPPSTL
THSPTPHASYNCSSELPGEEIAGS*RDALNVGGL
RHSWTPTCRGPDYVQ*PPEQQHTEGGSVQRPVL
KKSGAGVRPNHHHRRGGHGDGGGHRLPAEPLQS
LHAVLHQPPEPEPEAGGRAAADHACPAVQGQVHS
AVLHPEGSLQPLPAHLPLCAARD*SSSHHLPVR
R*RATSLPGALHPAAPGP*TADGTQPRVREGPT
QPNHI*Q*FNRHCYV*RGSMPTQQQLGHQCKHLQ
Q*REDGGATPHIQRGDGPPPRRLFPPSPAQQRT
QGQQTAVSAEQCREHNSTHQRQR*EAWEPGLIP
SNVHFSWRKKPRREAAAGPLLRTVLFSFTWYK*V
KPNEQTRSLFLIPFRGIACKLD*NDTNFHLV*P
QTVFIWGQGLGWGCGQGKTENGML*RYHEIKPT
EVFDVFNCERRLCR*MRPEWHVL*LTE*RRKHYY
ILLWGRTSQFAFSPKVWNFYFVLKI*IKIPVLC
AKV*SGEVR*VQGAPLCCDDVF*KLHYLNVENI
YKGTVLREVLYVVFSPVDCNQAQGISWSGPQKHP
RKDIWGRSLTFYQLT*IKKVIIVAGVCIK*QCI
AEAFGDFWMEDKIGKIKFQHF*LVILSYSATLR
LHSL*ENEHMHLWIQYHAVLPSSSSSAISSVI*I
FFTIA*NIFKYIPYFMQ*IV*NARWLFCILLKY
VTPQYIPIASPPFLDSLVQFCRAAQFTGGSQQP
PHIQPTQNFVWEWCGWWFLMLWKPLEIMTEECHV
ADRGNKPLWVIVCH*Y*HSILKGMQCSKPTQIP
AGFYQTLPQASFCTEGKNWTVREQWRGQVTEEH
RVKSTTCS*NATRKLILNIVSFNIPDIYKYSFLY
TMKKITFFCRCKHWLL*EQQPTRLADTARGEGL
ICSTLCHVEGGPLWPLHITR*AGMMIP*LPPMQ
P*SQIRVCVFVSVCGSRR*SVGAVALCCNWRDCS
KPQELSDPSLFPSASYLCR*VTGFCLFVLRIGI
SITFILCTQ*HPQN*SNS*KERGKTQAPVVSSC
LQPVWKYIQLRVTVEVLRLDSVLFQ*QLEGLCWR
DTSSQGRDWLGARRTLPNPGDTLKVHWLSRLAS
LPLSGKDEEPVFPSGPAGRDLQWILGQVCPQMR
RRGE*FHHFSSHLQFW*SRRCTPQL*LSNGFTVL
TSLPASRRGSEQRLVNSLVTVSI*MCCTCPQYW
RDNYIIQIPLIIFQERGSSHSTTLENCLC*IVI
*RLIHIKP*L*KVFEAGAL**ISLKAKVIT*IDG
QFPFSRRKR*FRSVALLKVVADLFIPCRLMASV
ALKE*RLGRYNLHSGAYCSFKNPFFSL*NPWVQ
FSNE*FRQSMIGL*S*IIPAKCGLHC*EEHLVGM
NTPGHTADFCPLFPV*ETQGILNPIYKNTIFQH
TFAFSETLAFSLNTDAILNGKEIS*SKLCISIV
LLFLVSKIY*YRSLTSMSSPSPPHKHMDTHPSHK
KSQESRSEFLKDLS*GLHFHSLILAQTYEAGNR
GQQ*MGEAS*HQQRNFVPRRGLLELLRISV*SL
SPLFHLHKNEKGSKGSTFRNLL*PRRIHPNPCLP
L*TNSSLL*QGPSSIFHPAALLFRKALVQSTSN
MSSGQILIASRETPGTQSEALPQRTGSWRWSLA
GSETFCCGRREPGPPCSHDWMRPHLGGLLHCLFI
EFCYLEWQH*LCVPFIF*KFSKARQCMKEKTGK
DTWFLLTFVLLA*VIKASAWSQAFMPRTCSTAC
PLLSCSH*PRMPRAWPTEVKGQLNDRWAKGELPL
LGARKVTNLKMLLPAQILNASSQQLRGLPFAIS
TTASCQHRYRSQRCEQTMESTLSLAVVYIF*EP
IFQHSLLPGTLCPLQSSSLCYCQGQTVICCCCCC
CCFSNWMH*EAAV*V*ECLAKKAMSSFILFFLP
SACPCFCVMRERVRAIEIIYTLSVHIIYM*IYP
YHVRDLHVSFSATKVPHVLSSADIGTKPPPPALD
APTFVVPHLKWCFFQLSVFSYVFICKVLYIS*I
YYAHILPNG*NKKLLIL*YNV*MIPILTEMA*N
L*MPMCFVLFCKEICKWMHTD*SLCSLFSY*ISI
L*HKRKKCEQTSNSL*PAYI*QWKVASLL*KHF
KENTF*KIPQLFGCH*TLLILIILVMLSWTSVS
YI*VRKMLFFNLLYNLLHLSPAVASRRCQATVKS
AHFCCCRNCVRGISKSACSRRLCSAPEASVTVC
VQVSLCLFLLQTEAVEPMK*Q*RL*GKNTSGKT
NTLTRRPCS*KMCLVMG*H*KRLGCQPAK*RTSH
PFPFMSHHNTDPKSKLGFAIS*KLRFGLYIVTS
LFRLSF*CLIVTSAFIFKYPNFKTKEQEKFITP
CSLKPRLNLGCGHPFECCP*EQFVEFCPSDPYYQ
LILPPE*SLINSKVFICSMVYVLTLKMSDSIII
PLTSRKQMTDYL*TEIDSTMQPLMLNGLKKSAL
LVSV*KGRKKLTLLLLWILRV*THVLFPSYTVGC
TPWDSSLRTEAHCCQKQSSHPPGSTLWENC*A*
ECSRLRGTKICYHIIASFLQDELRLKLYC**YW
FILMCLLVCCYFSFHSFQKSC*LYTCLV*GYFKI
CTILFTAFSSFNFYYKAIY*KSTTVFELFNSCL
*AMIIKSH*SLF*QTFVLTFQHNSQLYTEKDFH
LSRICLFYLSNGVVLRPKVCNCNTFKERCCSKCC
LLVMKSDFSACS*CCGQTIAQNH*K*SAAY
Sequence NM_181482
CCGAGCCCCGGAGGAAGCAGGCGTGTGTTGAATTTCTCTCTGCCCCTCACCTTGGAATAAACAGGAAGCGACAAGCACCCAGCCCGGCCCGGCACTTGCCTTTGTGAAGGGGTCTGCCCTGCACAGCCTTTAGGAAGCTTCCTCGGGACCCCTTCCCGGTGCGCCGCCCCGGGTGGGCCTGGGGGCGCGCCCTCGGTTCA
AGCTCTACGTTCGTGACATCAAACCTCCTGTTGGGCCATTTCCGAGAACTCCCATCAGTTTCTGTATAGTGTAAAAGTTTCAGAGGCGGAGCACAGAGAG
CTGCGGCTGGGACAAGGAGCACCCGCGTGCAGGTGCGACCCTGCAGGATGCTGGCAGCGGCGTGGCCAGGGGCGCCCGTGTTCTGAGGGCCTGAGGGCCA
GCCCCTCCACCCGCGCCATGGCCTCCGCGCCCTGGCTGGACGGCTGACGGGAGCAGGGACCGCCGCCGCCCAGGTGCCACACCCAGGTACCGCCCGCCCG
CGCGAGAGCCGGGCAGGTGGGCCGCGGATGCTCCCAGAGGCCGGCCCAGCAGAGCGATGGACTTGGACAGGCTAAGATGGAAGTGACCTGAGCCTCGCCC
GGCGGCTTCCTCGACGGGACAGCGCAAGAGTTGGAGCACAGGCTTGTCCGGGGAGCAGTATGCCGGAAGCTGGTTTTCAGGCCACAAATGCTTTCACAGA
GTGCAAATTCACCTGCACCAGTGGTAAATGCTTGTATCTTGGTTCGCTGGTCTGTAACCAACAGAACGACTGTGGGGACAACAGTGACGAAGAGAACTGT
CTCCTGGTGACCGAGCACCCGCCTCCGGGCATCTTCAACTCGGAGCTGGAGTTCGCCCAAATCATCATCATCGTCGTGGTGGTCACGGTGATGGTGGTGG
TCATCGTCTGCCTGCTGAACCACTACAAAGTCTCCACGCGGTCCTTCATCAACCGCCCGAACCAGAGCCGGAGGCGGGAGGACGGGCTGCCGCAGATCAT
GCATGCCCCGCGGTCCAGGGACAGGTTCACAGCGCCGTCCTTCATCCAGAGGGATCGCTTCAGCCGCTTCCAGCCCACCTACCCCTATGTGCAGCACGAG
ATTGATCTTCCTCCCACCATCTCCCTGTCCGACGGTGAAGAGCCACCTCCTTACCAGGGGCCCTGCACCCTGCAGCTCCGGGACCCTGAACAGCAGATGG
AACTCAACCGAGAGTCCGTGAGGGCCCCACCCAACCGAACCATATTTGACAGTGATTTAATAGACATTGCTATGTATAGCGGGGGTCCATGCCCACCCAG
CAGCAACTCGGGCATCAGTGCAAGCACCTGCAGCAGTAACGGGAGGATGGAGGGGCCACCCCCCACATACAGCGAGGTGATGGGCCACCACCCAGGCGCC
TCTTTCCTCCATCACCAGCGCAGCAACGCACACAGGGGCAGCAGACTGCAGTTTCAGCAGAACAATGCAGAGAGCACAATAGTACCCATCAAAGGCAAAG
ATAGGAAGCCTGGGAACCTGGTCTGATTCCTTCCAACGTGCACTTCAGCTGGAGAAAGAAACCAAGAAGGGAAGCGGCCGCTGGGCCCCTCCTGCGCACA
GTGTTGTTCAGTTTCACATGGTACAAATAAGTAAAACCAAATGAGCAAACACGGTCTTTGTTTCTGATTCCTTTTAGGGGAATTGCATGCAAACTAGACT
GAAATGATACAAACTTCCATCTGGTCTGACCGCAAACAGTGTTTATTTGGGGACAGGGGTTGGGATGGGGGTGTGGGCAGGGGAAAACAGAGAACGGGAT
GCTTTGAAGATACCATGAAATAAAACCCACAGAGGTATTTGATGTATTTAATTGTGAAAGGAGACTTTGCAGATAAATGAGGCCAGAATGGCATGTTTTA
TAATTAACTGAATAAAGAAGGAAGCATTATTATATATTATTGTGGGGAAGAACCAGCCAGTTCGCTTTTTCTCCTAAGGTGTGGAACTTTTATTTTGTTT
TAAAAATATGAATCAAAATTCCTGTGTTGTGTGCCAAGGTATAAAGTGGAGAAGTTAGATGAGTGCAAGGAGCTCCTTTGTGTTGTGATGATGTGTTTTA
AAAGTTGCACTATCTTAATGTTGAAAATATTTACAAGGGAACTGTTTTACGTGAAGTTCTGTATGTTGTCTTTTCACCTGTGGATTGTAATCAGGCCCAA
GGAATATCCTGGAGTGGTCCCCAGAAGCATCCAAGAAAAGATATTTGGGGACGTAGCCTAACATTTTACCAACTTACGTAAATCAAAAAAGTCATTATTG
TTGCAGGAGTTTGCATCAAATAGCAGTGCATCGCTGAAGCTTTTGGAGACTTTTGGATGGAAGATAAGATAGGGAAGATTAAGTTCCAGCATTTCTGACT
TGTTATTTTGAGTTACTCTGCTACTCTTAGGCTGCATAGTTTATGAGAAAATGAACACATGCATTTATGGATCCAGTATCATGCAGTGCTGCCCTCATCC
TCCAGCAGTGCAATTTCTTCAGTAATTTAGATTTTTTTCACTATAGCATGAAATATATTCAAATACATACCTTATTTTATGCAATAAATTGTTTAAAATG
CAAGGTGGTTATTCTGCATACTGTTGAAATATGTGACTCCTCAGTATATTCCCATTGCCTCTCCCCCTTTCCTCGACAGCTTAGTTCAGTTCTGCAGGGC
TGCTCAGTTCACAGGAGGCTCCCAGCAGCCACCCCACATCCAGCCTACACAGAACTTCGTGTGGGAGTGGTGTGGGTGGTGGTTTCTTATGCTTTGGAAG
CCCCTAGAAATAATGACGGAAGAATGCCATGTTGCTGATCGTGGTAATAAGCCATTGTGGGTTATTGTATGTCACTAGTATTAGCATAGCATTCTTAAAG
GAATGCAGTGCTCAAAACCTACCCAAATTCCCGCAGGATTCTACCAAACCCTTCCCCAGGCCAGCTTTTGTACTGAAGGCAAGAACTGGACAGTCAGAGA
ACAGTGGAGGGGGCAAGTGACTGAAGAGCACCGGGTAAAAAGCACAACATGCAGTTAAAATGCAACTAGAAAACTAATTTTAAATATTGTTAGTTTTAAT
ATTCCTGATATTTACAAATATTCATTCTTATATACAATGAAAAAAATAACTTTCTTCTGCAGATGTAAGCACTGGCTTTTATAAGAGCAGCAGCCAACAC
GTTTAGCAGACACTGCGCGTGGAGAAGGGCTTATCTGCAGTACACTCTGCCATGTGGAGGGTGGGCCTCTGTGGCCTCTTCACATAACAAGATGAGCTGG
AATGATGATTCCATGACTCCCACCTATGCAGCCTTAAAGCCAAATCCGCGTGTGTGTGTTTGTGTCTGTCTGTGGGTCTCGAAGGTGATCCGTCGGTGCG
GTGGCTCTGTGCTGTAACTGGAGAGACTGTTCCAAACCCCAAGAGTTGTCTGATCCTAGTCTGTTCCCTTCTGCTTCTTACCTCTGTAGATAGGTCACTG
GTTTTTGTTTGTTTGTTTTGAGGATTGGAATTTCCATTACATTCATCCTTTGCACACAGTAACATCCACAGAACTAGTCCAACTCTTAAAAGGAGAGAGG
AAAAACACAGGCACCAGTTGTCAGCTCATGCTTACAACCTGTGTGGAAGTATATACAGTTGAGAGTCACAGTGGAGGTTCTGAGACTGGATTCAGTCTTG
TTCCAGTGACAGTTGGAAGGCCTCTGCTGGAGAGACACCAGCTCTCAGGGCAGAGATTGGCTTGGGGCCAGAAGGACCCTCCCCAACCCTGGAGACACCC
TGAAGGTTCACTGGCTCTCCAGATTAGCCTCTCTTCCTCTGTCAGGCAAAGATGAGGAGCCCGTGTTCCCATCGGGCCCTGCTGGCAGGGACTTGCAGTG
GATTCTTGGTCAGGTGTGCCCACAGATGCGGAGGCGAGGTGAGTGATTCCATCATTTCAGTTCTCACCTGCAGTTTTGGTGAAGCAGGAGATGCACCCCA
CAGCTCTAGCTCTCAAATGGCTTCACAGTCCTTACTTCTCTACCTGCCTCAAGAAGGGGCTCAGAGCAGAGACTTGTGAATTCCTTAGTAACTGTGAGTA
TATGAATGTGTTGCACATGTCCACAGTATTGGCGAGATAATTACATAATTCAGATACCTTTAATCATCTTTCAAGAAAGAGGCTCCTCCCATTCAACCAC
CCTAGAGAACTGCCTTTGTTAAATAGTTATTTAAAGACTCATACATATCAAACCATGACTTTGAAAGGTCTTCGAGGCTGGGGCTCTGTAATGAATTAGT
TTAAAAGCCAAGGTCATAACATGAATTGATGGTCAATTTCCCTTCAGCAGAAGGAAAAGGTGATTTAGATCAGTAGCTCTTTTGAAGGTTGTGGCTGACC
TGTTCATACCGTGTCGCCTCATGGCTAGTGTGGCGTTGAAAGAGTAGCGACTGGGAAGATACAACTTACACAGTGGGGCCTATTGTTCTTTCAAGAACCC
TTTTTTTAGCTTATAGAACCCATGGGTCCAGTTTAGTAACGAGTGATTTAGGCAATCAATGATAGGTTTATAATCTTAGATTATTCCAGCAAAGTGTGGA
TTGCATTGTTAGGAAGAACATTTGGTGGGAATGAACACTCCTGGGCATACCGCTGACTTTTGTCCCTTGTTCCCGGTGTAGGAGACCCAAGGCATCTTGA
ATCCCATCTATAAGAACACAATCTTCCAGCATACGTTTGCTTTTTCAGAAACTCTAGCATTCTCTTTAAATACTGACGCAATCCTTAATGGAAAAGAGAT
TTCATGAAGCAAATTATGTATTTCAATAGTTCTTCTATTTTTAGTGTCCAAAATTTACTAATACAGAAGCTTGACAAGCATGTCCTCACCCTCCCCACCA
CATAAACACATGGACACACACCCAAGCCACAAGAAATCCCAAGAGAGCAGAAGCGAATTTTTAAAAGATTTATCGTGAGGACTGCATTTCCATTCACTAA
TTTTGGCTCAAACTTATGAGGCAGGAAATAGGGGCCAACAGTAAATGGGGGAGGCCTCCTGACACCAGCAGAGGAATTTTGTACCCAGGCGAGGACTTCT
TGAACTTCTGCGTATCTCCGTTTGATCTCTTTCACCTTTATTTCATCTTCATAAGAATGAGAAAGGCTCAAAAGGAAGCACTTTTAGAAATCTTCTCTGA
CCTAGAAGAATCCATCCAAATCCCTGCCTTCCTCTCTGAACCAACAGTTCCCTTCTCTGACAGGGGCCATCCTCTATCTTCCATCCAGCGGCTCTTCTTT
TTAGGAAGGCTCTGGTGCAGAGCACTTCAAATATGTCCTCAGGCCAGATACTGATTGCTAGTAGAGAGACACCCGGCACCCAGTCCGAAGCCCTCCCTCA
AAGGACCGGCTCATGGCGTTGGTCACTGGCAGGCTCAGAGACATTCTGCTGTGGGCGCAGGGAGCCCGGCCCCCCATGCAGCCATGACTGGATGCGCCCC
CATCTCGGGGGCTTGCTGCACTGCTTGTTTATTGAATTTTGCTACTTAGAATGGCAACATTAACTTTGTGTACCATTCATTTTTTAAAAATTTTCCAAAG
CTCGGCAGTGTATGAAAGAAAAAACTGGGAAAGATACTTGGTTTCTGTTAACTTTTGTGTTGCTTGCTTAAGTGATTAAAGCCAGTGCTTGGAGCCAAGC
CTTCATGCCACGAACATGCTCCACAGCCTGCCCTTTGCTCTCCTGCTCACACTGACCAAGAATGCCGCGTGCTTGGCCTACTGAGGTGAAAGGACAATTG
AATGACAGGTGGGCAAAGGGAGAACTTCCCCTTCTTGGTGCGAGGAAAGTCACAAATTTAAAAATGTTGCTTCCAGCCCAGATCCTAAATGCTAGTTCTC
AGCAGCTGCGTGGCTTACCGTTCGCCATTTCCACCACCGCCAGCTGCCAGCACCGCTACAGATCACAGAGATGTGAACAGACAATGGAAAGCACTCTTAG
CCTTGCAGTGGTCTACATTTTTTAGGAACCAATATTTCAGCATTCTTTATTACCCGGCACGCTGTGTCCTTTGCAGAGTTCAAGTTTATGTTACTGCCAG
GGTCAGACAGTCATTTGCTGCTGCTGCTGCTGCTGCTGCTTCTCGAACTGGATGCATTAGGAAGCTGCTGTCTGAGTGTAGGAATGTCTTGCTAAGAAAG
CAATGTCTTCCTTCATCCTTTTCTTTCTTCCCTCTGCGTGTCCTTGTTTTTGTGTAATGCGGGAGAGGGTTAGAGCTATAGAGATTATATATACACTATC
CGTGCACATTATATATATGTAGATATACCCCTATCATGTCAGAGATCTGCATGTCAGTTTTTCAGCAACTAAGGTGCCTCATGTTCTGAGTTCAGCAGAT
ATAGGAACCAAGCCGCCCCCTCCTGCACTTGATGCTCCCACCTTTGTTGTGCCTCACTTAAAATGGTGCTTTTTTCAGTTGTCTGTCTTTTCTTATGTTT
TTATTTGTAAGGTGCTGTATATAAGTTGAATATATTATGCACATATCCTACCCAATGGGTAGAACAAAAAGTTGTTAATACTGTAATATAATGTATAGAT
GATACCAATTTTAACAGAAATGGCATAGAATTTGTGAATGCCTATGTGCTTTGTCCTCTTTTGTAAGGAAATTTGCAAATGGATGCATACAGATTAAAGT
CTATGTAGTTTATTTTCCTATTAAATATCAATATTATAACACAAGAGAAAGAAGTGTGAACAAACAAGCAACAGTTTATGACCAGCGTATATATAGCAAT
GGAAAGTTGCATCTTTGCTGTGAAAACACTTTAAAGAAAATACTTTTTAAAAAATCCCACAGCTTTTTGGTTGCCACTAGACGCTTCTTATTTTAATCAT
TTTAGTAATGCTCAGCTGGACCAGTGTTAGTTATATTTGAGTCAGAAAAATGTTGTTTTTCAACTTGCTTTATAATCTCCTGCATCTATCTCCTGCTGTA
GCATCACGAAGGTGTCAGGCAACAGTGAAAAGTGCACATTTTTGTTGTTGCAGAAACTGTGTCAGAGGAATAAGTAAATCAGCCTGCAGCAGAAGACTTT
GTTCAGCTCCAGAGGCATCTGTGACCGTCTGTGTCCAAGTCTCTCTGTGCCTTTTTCTTTTACAAACTGAAGCTGTGGAGCCAATGAAGTAACAGTAGAG
ATTGTAGGGAAAGAATACCTCAGGAAAAACAAATACACTTACAAGAAGACCCTGTTCTTAGAAAATGTGTTTAGTTATGGGTTAGCACTAGAAGAGACTT
GGCTGTCAGCCAGCCAAGTGAAGGACCTCTCATCCATTCCCATTCATGTCCCATCATAATACGGACCCAAAAAGCAAACTCGGTTTTGCCATCAGTTAGA
AATTACGTTTTGGATTGTATATTGTTACATCTCTCTTCCGGCTTAGTTTTTAGTGTCTGATTGTGACCTCTGCATTTATCTTCAAATACCCTAATTTTAA
AACAAAAGAACAAGAAAAGTTTATAACACCATGTTCACTAAAACCACGGTTGAATCTTGGGTGTGGGCATCCTTTCGAGTGTTGTCCATAAGAGCAGTTC
GTGGAATTTTGCCCATCTGACCCATATTATCAGCTTATTCTGCCACCAGAGTAGAGTCTAATAAATTCCAAAGTTTTTATTTGCTCCATGGTGTATGTTC
TGACTTTGAAAATGTCAGATTCTATAATCATACCCCTAACATCCAGGAAACAAATGACAGATTATCTTTAAACTGAAATTGACTCTACAATGCAACCCTT
AATGCTGAATGGATTAAAAAAGTCAGCCCTTTTAGTATCTGTTTGAAAGGGCCGTAAAAAGTTGACACTTTTGTTGTTGTGGATCCTGCGTGTCTAGACC
CACGTGTTGTTTCCATCGTATACTGTAGGGTGCACCCCTTGGGATTCATCATTAAGAACTGAGGCTCACTGTTGTCAGAAACAAAGCTCCCACCCCCCAG
GTTCAACCTTGTGGGAGAACTGTTGAGCATGAGAATGTTCTAGACTCAGAGGTACTAAAATTTGTTACCACATCATTGCTTCCTTTCTACAGGACGAATT
GAGGCTTAAACTTTACTGTTAATGATACTGGTTCATTTTAATGTGCTTGTTGGTATGTTGCTATTTTTCATTTCATAGCTTTCAAAAATCATGCTAATTG
TATACTTGTCTAGTTTAAGGCTATTTTAAAATATGTACAATACTATTCACAGCATTTAGTTCGTTTAATTTTTATTATAAAGCAATCTACTAAAAAAGTA
CAACTGTATTTGAACTTTTCAATAGTTGTTTGTGAGCTATGATAATCAAAAGTCATTAAAGTCTTTTTTAACAAACATTCGTGCTTACTTTTCAACATAA
TTCCCAGTTATATACAGAAAAAGATTTCCACCTGTCACGTATCTGCCTCTTTTACCTGAGCAATGGTGTAGTTCTTAGACCTAAGGTCTGTAATTGCAAT
ACTTTTAAAGAAAGATGTTGCTCTAAGTGCTGTTTGTTAGTTATGAAATCAGATTTTTCTGCTTGTTCTTAATGCTGTGGTCAAACCATAGCACAAAATC
ATTAAAAATAATCAGCGGCATAC
- refseq_C18orf1.F1 (forward primer)
- refseq_C18orf1.R1 (reverse primer)
- Single exon skipping
Frame 0
PSPGGSRRVLNFSLPLTLE*TGSDKHPARPGTCLCEGVCPAQPLGSFLGTPSRCAAPGGPGGAPSVQ
ALRS*HQTSCWAISENSHQFLYSVKVSEAEHRE
LRLGQGAPACRCDPAGCWQRRGQGRPCSEGLRA
SPSTRAMASAPWLDG*REQGPPPPRCHTQVPPAR
ARAGQVGRGCSQRPAQQSDGLGQAKMEVT*ASP
GGFLDGTAQELEHRLVRGAVCRKLVFRPQMLSQ
SANSPAPVVNACILVRWSVTNRTTVGTTVTKRTV
SW*PSTRLRASSTRSWSSPKSSSSSWWSR*WWW
SSSAC*TTTKSPRGPSSTARTRAGGGRTGCRRS
CMPRGPGTGSQRRPSSRGIASAASSPPTPMCSTR
LIFLPPSPCPTVKSHLLTRGPAPCSSGTLNSRW
NSTESP*GPHPTEPYLTVI**TLLCIAGVHAHP
AATRASVQAPAAVTGGWRGHPPHTAR*WATTQAP
LSSITSAATHTGAADCSFSRTMQRAQ*YPSKAK
IGSLGTWSDSFQRALQLEKETKKGSGRWAPPAH
SVVQFHMVQISKTK*ANTVFVSDSF*GNCMQTRL
K*YKLPSGLTANSVYLGTGVGMGVWAGENRERD
ALKIP*NKTHRGI*CI*L*KETLQINEARMACF
IIN*IKKEALLYIIVGKNQPVRFFS*GVELLFCF
KNMNQNSCVVCQGIKWRS*MSARSSFVL**CVL
KVALS*C*KYLQGNCFT*SSVCCLFTCGL*SGP
RNILEWSPEASKKRYLGT*PNILPTYVNQKSHYC
CRSLHQIAVHR*SFWRLLDGR*DRED*VPAFLT
CYFELLCYS*AA*FMRK*THAFMDPVSCSAALI
LQQCNFFSNLDFFHYSMKYIQIHTLFYAINCLKC
KVVILHTVEICDSSVYSHCLSPFPRQLSSVLQG
CSVHRRLPAATPHPAYTELRVGVVWVVVSYALE
APRNNDGRMPCC*SW**AIVGYCMSLVLA*HS*R
NAVLKTYPNSRRILPNPSPGQLLY*RQELDSQR
TVEGASD*RAPGKKHNMQLKCN*KTNFKYC*F*
YS*YLQIFILIYNEKNNFLLQM*ALAFIRAAANT
FSRHCAWRRAYLQYTLPCGGWASVASSHNKMSW
NDDSMTPTYAALKPNPRVCVCVCLWVSKVIRRC
GGSVL*LERLFQTPRVV*S*SVPFCFLPL*IGHW
FLFVCFEDWNFHYIHPLHTVTSTELVQLLKGER
KNTGTSCQLMLTTCVEVYTVESHSGGSETGFSL
VPVTVGRPLLERHQLSGQRLAWGQKDPPQPWRHP
EGSLALQISLSSSVRQR*GARVPIGPCWQGLAV
DSWSGVPTDAEAR*VIPSFQFSPAVLVKQEMHP
TALALKWLHSPYFSTCLKKGLRAETCEFLSNCEY
MNVLHMSTVLAR*LHNSDTFNHLSRKRLLPFNH
PRELPLLNSYLKTHTYQTMTLKGLRGWGSVMN*
FKSQGHNMN*WSISLQQKEKVI*ISSSFEGCG*P
VHTVSPHG*CGVERVATGKIQLTQWGLLFFQEP
FF*LIEPMGPV**RVI*AINDRFIILDYSSKVW
IALLGRTFGGNEHSWAYR*LLSLVPGVGDPRHLE
SHL*EHNLPAYVCFFRNSSILFKY*RNP*WKRD
FMKQIMYFNSSSIFSVQNLLIQKLDKHVLTLPT
T*THGHTPKPQEIPREQKRIFKRFIVRTAFPFTN
FGSNL*GRK*GPTVNGGGLLTPAEEFCTQARTS
*TSAYLRLISFTFISSS*E*ERLKRKHF*KSSL
T*KNPSKSLPSSLNQQFPSLTGAILYLPSSGSSF
*EGSGAEHFKYVLRPDTDC**RDTRHPVRSPPS
KDRLMALVTGRLRDILLWAQGARPPMQP*LDAP
PSRGLAALLVY*ILLLRMATLTLCTIHFLKIFQS
SAVYERKNWERYLVSVNFCVACLSD*SQCLEPS
LHATNMLHSLPFALLLTLTKNAACLAY*GERTI
E*QVGKGRTSPSWCEESHKFKNVASSPDPKC*FS
AAAWLTVRHFHHRQLPAPLQITEM*TDNGKHS*
PCSGLHFLGTNISAFFITRHAVSFAEFKFMLLP
GSDSHLLLLLLLLLLELDALGSCCLSVGMSC*ES
NVFLHPFLSSLCVSLFLCNAGEG*SYRDYIYTI
RAHYIYVDIPLSCQRSACQFFSN*GASCSEFSR
YRNQAAPSCT*CSHLCCASLKMVLFSVVCLFLCF
YL*GAVYKLNILCTYPTQWVEQKVVNTVI*CID
DTNFNRNGIEFVNAYVLCPLL*GNLQMDAYRLK
SM*FIFLLNINIITQEKEV*TNKQQFMTSVYIAM
ESCIFAVKTL*RKYFLKNPTAFWLPLDASYFNH
FSNAQLDQC*LYLSQKNVVFQLAL*SPASISCC
SITKVSGNSEKCTFLLLQKLCQRNK*ISLQQKTL
FSSRGICDRLCPSLSVPFSFTN*SCGANEVTVE
IVGKEYLRKNKYTYKKTLFLENVFSYGLALEET
WLSASQVKDLSSIPIHVPS*YGPKKQTRFCHQLE
ITFWIVYCYISLPA*FLVSDCDLCIYLQIP*F*
NKRTRKVYNTMFTKTTVESWVWASFRVLSIRAV
RGILPI*PILSAYSATRVESNKFQSFYLLHGVCS
DFENVRFYNHTPNIQETNDRLSLN*N*LYNATL
NAEWIKKVSPFSICLKGP*KVDTFVVVDPACLD
PRVVSIVYCRVHPLGFIIKN*GSLLSETKLPPPR
FNLVGELLSMRMF*TQRY*NLLPHHCFLSTGRI
EA*TLLLMILVHFNVLVGMLLFFIS*LSKIMLI
VYLSSLRLF*NMYNTIHSI*FV*FLL*SNLLKKY
NCI*TFQ*LFVSYDNQKSLKSFLTNIRAYFST*
FPVIYRKRFPPVTYLPLLPEQWCSS*T*GL*LQ
YF*RKMLL*VLFVSYEIRFFCLFLMLWSNHSTKS
LKIISGI
Frame 1
RAPEEAGVC*ISLCPSPWNKQEATSTQPGPALAFVKGSALHSL*EASSGPLPGAPPRVGLGARPRF
KLYVRDIKPPVGPFPRTPISFCIV*KFQRRSTES
CGWDKEHPRAGATLQDAGSGVARGARVLRA*GP
APPPAPWPPRPGWTADGSRDRRRPGATPRYRPP
AREPGRWAADAPRGRPSRAMDLDRLRWK*PEPRP
AASSTGQRKSWSTGLSGEQYAGSWFSGHKCFHR
VQIHLHQW*MLVSWFAGL*PTERLWGQQ*RREL
SPGDRAPASGHLQLGAGVRPNHHHRRGGHGDGGG
HRLPAEPLQSLHAVLHQPPEPEPEAGGRAAADH
ACPAVQGQVHSAVLHPEGSLQPLPAHLPLCAAR
D*SSSHHLPVRR*RATSLPGALHPAAPGP*TADG
TQPRVREGPTQPNHI*Q*FNRHCYV*RGSMPTQ
QQLGHQCKHLQQ*REDGGATPHIQRGDGPPPRR
LFPPSPAQQRTQGQQTAVSAEQCREHNSTHQRQR
*EAWEPGLIPSNVHFSWRKKPRREAAAGPLLRT
VLFSFTWYK*VKPNEQTRSLFLIPFRGIACKLD
*NDTNFHLV*PQTVFIWGQGLGWGCGQGKTENGM
L*RYHEIKPTEVFDVFNCERRLCR*MRPEWHVL
*LTE*RRKHYYILLWGRTSQFAFSPKVWNFYFV
LKI*IKIPVLCAKV*SGEVR*VQGAPLCCDDVF*
KLHYLNVENIYKGTVLREVLYVVFSPVDCNQAQ
GISWSGPQKHPRKDIWGRSLTFYQLT*IKKVII
VAGVCIK*QCIAEAFGDFWMEDKIGKIKFQHF*L
VILSYSATLRLHSL*ENEHMHLWIQYHAVLPSS
SSSAISSVI*IFFTIA*NIFKYIPYFMQ*IV*N
ARWLFCILLKYVTPQYIPIASPPFLDSLVQFCRA
AQFTGGSQQPPHIQPTQNFVWEWCGWWFLMLWK
PLEIMTEECHVADRGNKPLWVIVCH*Y*HSILK
GMQCSKPTQIPAGFYQTLPQASFCTEGKNWTVRE
QWRGQVTEEHRVKSTTCS*NATRKLILNIVSFN
IPDIYKYSFLYTMKKITFFCRCKHWLL*EQQPT
RLADTARGEGLICSTLCHVEGGPLWPLHITR*AG
MMIP*LPPMQP*SQIRVCVFVSVCGSRR*SVGA
VALCCNWRDCSKPQELSDPSLFPSASYLCR*VT
GFCLFVLRIGISITFILCTQ*HPQN*SNS*KERG
KTQAPVVSSCLQPVWKYIQLRVTVEVLRLDSVL
FQ*QLEGLCWRDTSSQGRDWLGARRTLPNPGDT
LKVHWLSRLASLPLSGKDEEPVFPSGPAGRDLQW
ILGQVCPQMRRRGE*FHHFSSHLQFW*SRRCTP
QL*LSNGFTVLTSLPASRRGSEQRLVNSLVTVS
I*MCCTCPQYWRDNYIIQIPLIIFQERGSSHSTT
LENCLC*IVI*RLIHIKP*L*KVFEAGAL**IS
LKAKVIT*IDGQFPFSRRKR*FRSVALLKVVAD
LFIPCRLMASVALKE*RLGRYNLHSGAYCSFKNP
FFSL*NPWVQFSNE*FRQSMIGL*S*IIPAKCG
LHC*EEHLVGMNTPGHTADFCPLFPV*ETQGIL
NPIYKNTIFQHTFAFSETLAFSLNTDAILNGKEI
S*SKLCISIVLLFLVSKIY*YRSLTSMSSPSPP
HKHMDTHPSHKKSQESRSEFLKDLS*GLHFHSL
ILAQTYEAGNRGQQ*MGEAS*HQQRNFVPRRGLL
ELLRISV*SLSPLFHLHKNEKGSKGSTFRNLL*
PRRIHPNPCLPL*TNSSLL*QGPSSIFHPAALL
FRKALVQSTSNMSSGQILIASRETPGTQSEALPQ
RTGSWRWSLAGSETFCCGRREPGPPCSHDWMRP
HLGGLLHCLFIEFCYLEWQH*LCVPFIF*KFSK
ARQCMKEKTGKDTWFLLTFVLLA*VIKASAWSQA
FMPRTCSTACPLLSCSH*PRMPRAWPTEVKGQL
NDRWAKGELPLLGARKVTNLKMLLPAQILNASS
QQLRGLPFAISTTASCQHRYRSQRCEQTMESTLS
LAVVYIF*EPIFQHSLLPGTLCPLQSSSLCYCQ
GQTVICCCCCCCCFSNWMH*EAAV*V*ECLAKK
AMSSFILFFLPSACPCFCVMRERVRAIEIIYTLS
VHIIYM*IYPYHVRDLHVSFSATKVPHVLSSAD
IGTKPPPPALDAPTFVVPHLKWCFFQLSVFSYV
FICKVLYIS*IYYAHILPNG*NKKLLIL*YNV*M
IPILTEMA*NL*MPMCFVLFCKEICKWMHTD*S
LCSLFSY*ISIL*HKRKKCEQTSNSL*PAYI*Q
WKVASLL*KHFKENTF*KIPQLFGCH*TLLILII
LVMLSWTSVSYI*VRKMLFFNLLYNLLHLSPAV
ASRRCQATVKSAHFCCCRNCVRGISKSACSRRL
CSAPEASVTVCVQVSLCLFLLQTEAVEPMK*Q*R
L*GKNTSGKTNTLTRRPCS*KMCLVMG*H*KRL
GCQPAK*RTSHPFPFMSHHNTDPKSKLGFAIS*
KLRFGLYIVTSLFRLSF*CLIVTSAFIFKYPNFK
TKEQEKFITPCSLKPRLNLGCGHPFECCP*EQF
VEFCPSDPYYQLILPPE*SLINSKVFICSMVYV
LTLKMSDSIIIPLTSRKQMTDYL*TEIDSTMQPL
MLNGLKKSALLVSV*KGRKKLTLLLLWILRV*T
HVLFPSYTVGCTPWDSSLRTEAHCCQKQSSHPP
GSTLWENC*A*ECSRLRGTKICYHIIASFLQDEL
RLKLYC**YWFILMCLLVCCYFSFHSFQKSC*L
YTCLV*GYFKICTILFTAFSSFNFYYKAIY*KS
TTVFELFNSCL*AMIIKSH*SLF*QTFVLTFQHN
SQLYTEKDFHLSRICLFYLSNGVVLRPKVCNCN
TFKERCCSKCCLLVMKSDFSACS*CCGQTIAQN
H*K*SAAY
Frame 2
EPRRKQACVEFLSAPHLGINRKRQAPSPARHLPL*RGLPCTAFRKLPRDPFPVRRPGWAWGRALGS
SSTFVTSNLLLGHFRELPSVSV*CKSFRGGAQR
AAAGTRSTRVQVRPCRMLAAAWPGAPVF*GPEGQ
PLHPRHGLRALAGRLTGAGTAAAQVPHPGTARP
RESRAGGPRMLPEAGPAERWTWTG*DGSDLSLA
RRLPRRDSARVGAQACPGSSMPEAGFQATNAFTE
CKFTCTSGKCLYLGSLVCNQQNDCGDNSDEENC
LLVTEHPPPGIFNSELEFAQIIIIVVVVTVMVV
VIVCLLNHYKVSTRSFINRPNQSRRREDGLPQIM
HAPRSRDRFTAPSFIQRDRFSRFQPTYPYVQHE
IDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQM
ELNRESVRAPPNRTIFDSDLIDIAMYSGGPCPPS
SNSGISASTCSSNGRMEGPPPTYSEVMGHHPGA
SFLHHQRSNAHRGSRLQFQQNNAESTIVPIKGK
DRKPGNLV*FLPTCTSAGERNQEGKRPLGPSCAQ
CCSVSHGTNK*NQMSKHGLCF*FLLGELHAN*T
EMIQTSIWSDRKQCLFGDRGWDGGVGRGKQRTG
CFEDTMK*NPQRYLMYLIVKGDFADK*GQNGMFY
N*LNKEGSIIIYYCGEEPASSLFLLRCGTFILF
*KYESKFLCCVPRYKVEKLDECKELLCVVMMCF
KSCTILMLKIFTRELFYVKFCMLSFHLWIVIRPK
EYPGVVPRSIQEKIFGDVA*HFTNLRKSKKSLL
LQEFASNSSASLKLLETFGWKIR*GRLSSSISD
LLF*VTLLLLGCIVYEKMNTCIYGSSIMQCCPHP
PAVQFLQ*FRFFSL*HEIYSNTYLILCNKLFKM
QGGYSAYC*NM*LLSIFPLPLPLSSTA*FSSAG
LLSSQEAPSSHPTSSLHRTSCGSGVGGGFLCFGS
P*K**RKNAMLLIVVISHCGLLYVTSISIAFLK
ECSAQNLPKFPQDSTKPFPRPAFVLKARTGQSE
NSGGGK*LKSTG*KAQHAVKMQLEN*F*ILLVLI
FLIFTNIHSYIQ*KK*LSSADVSTGFYKSSSQH
V*QTLRVEKGLSAVHSAMWRVGLCGLFT*QDEL
E**FHDSHLCSLKAKSACVCLCLSVGLEGDPSVR
WLCAVTGETVPNPKSCLILVCSLLLLTSVDRSL
VFVCLF*GLEFPLHSSFAHSNIHRTSPTLKRRE
EKHRHQLSAHAYNLCGSIYS*ESQWRF*DWIQSC
SSDSWKASAGETPALRAEIGLGPEGPSPTLETP
*RFTGSPD*PLFLCQAKMRSPCSHRALLAGTCS
GFLVRCAHRCGGEVSDSIISVLTCSFGEAGDAPH
SSSSQMASQSLLLYLPQEGAQSRDL*IP**L*V
YECVAHVHSIGEIIT*FRYL*SSFKKEAPPIQP
P*RTAFVK*LFKDSYISNHDFERSSRLGLCNELV
*KPRS*HELMVNFPSAEGKGDLDQ*LF*RLWLT
CSYRVASWLVWR*KSSDWEDTTYTVGPIVLSRT
LFLAYRTHGSSLVTSDLGNQ**VYNLRLFQQSVD
CIVRKNIWWE*TLLGIPLTFVPCSRCRRPKAS*
IPSIRTQSSSIRLLFQKL*HSL*ILTQSLMEKR
FHEANYVFQ*FFYF*CPKFTNTEA*QACPHPPHH
INTWTHTQATRNPKRAEANF*KIYREDCISIH*
FWLKLMRQEIGANSKWGRPPDTSRGILYPGEDF
LNFCVSPFDLFHLYFIFIRMRKAQKEALLEIFSD
LEESIQIPAFLSEPTVPFSDRGHPLSSIQRLFF
LGRLWCRALQICPQARY*LLVERHPAPSPKPSL
KGPAHGVGHWQAQRHSAVGAGSPAPHAAMTGCAP
ISGACCTACLLNFAT*NGNINFVYHSFFKNFPK
LGSV*KKKLGKILGFC*LLCCLLK*LKPVLGAK
PSCHEHAPQPALCSPAHTDQECRVLGLLR*KDN*
MTGGQRENFPFLVRGKSQI*KCCFQPRS*MLVL
SSCVAYRSPFPPPPAASTATDHRDVNRQWKALL
ALQWSTFFRNQYFSILYYPARCVLCRVQVYVTAR
VRQSFAAAAAAAASRTGCIRKLLSECRNVLLRK
QCLPSSFSFFPLRVLVFV*CGRGLEL*RLYIHY
PCTLYICRYTPIMSEICMSVFQQLRCLMF*VQQI
*EPSRPLLHLMLPPLLCLT*NGAFFSCLSFLMF
LFVRCCI*VEYIMHISYPMGRTKSC*YCNIMYR
*YQF*QKWHRICECLCALSSFVRKFANGCIQIKV
YVVYFPIKYQYYNTRERSVNKQATVYDQRIYSN
GKLHLCCENTLKKILFKKSHSFLVATRRFLF*S
F**CSAGPVLVIFESEKCCFSTCFIISCIYLLL*
HHEGVRQQ*KVHIFVVAETVSEE*VNQPAAEDF
VQLQRHL*PSVSKSLCAFFFYKLKLWSQ*SNSR
DCRERIPQEKQIHLQEDPVLRKCV*LWVSTRRDL
AVSQPSEGPLIHSHSCPIIIRTQKANSVLPSVR
NYVLDCILLHLSSGLVFSV*L*PLHLSSNTLIL
KQKNKKSL*HHVH*NHG*ILGVGILSSVVHKSSS
WNFAHLTHIISLFCHQSRV**IPKFLFAPWCMF
*L*KCQIL*SYP*HPGNK*QIIFKLKLTLQCNP
*C*MD*KSQPF*YLFERAVKS*HFCCCGSCVSRP
TCCFHRIL*GAPLGIHH*ELRLTVVRNKAPTPQ
VQPCGRTVEHENVLDSEVLKFVTTSLLPFYRTN
*GLNFTVNDTGSF*CACWYVAIFHFIAFKNHANC
ILV*FKAILKYVQYYSQHLVRLIFIIKQSTKKV
QLYLNFSIVVCEL**SKVIKVFFNKHSCLLFNI
IPSYIQKKISTCHVSASFT*AMV*FLDLRSVIAI
LLKKDVALSAVC*L*NQIFLLVLNAVVKP*HKI
IKNNQRH
Sequence NM_181483
CTCAGCTCCCTGTGGTGGGGGATGGCAGAGGCTTCCCGCTCCCCGCAGCTGGTTTGCACAGCCTCCCGACTGTGCCGTGGTGTCTCCTTCCCTAAAGTGGGACAGTCGTTTCTGTGTCCTGCTGGCCTCTGAGGAACAGACGTGTGTGAGAGGCCTTCAGGGCCTGATGGCTGGGGTGGTGACAGTGCCTGGAGAATGGG
TGGGGACTGGAGGGGCCAGGTGGCTAACCACTCTCCTCTTCCATGGCAGCGGAGCTGGAGTTCGCCCAAATCATCATCATCGTCGTGGTGGTCACGGTGA
TGGTGGTGGTCATCGTCTGCCTGCTGAACCACTACAAAGTCTCCACGCGGTCCTTCATCAACCGCCCGAACCAGAGCCGGAGGCGGGAGGACGGGCTGCC
GCAGATCATGCATGCCCCGCGGTCCAGGGACAGGTTCACAGCGCCGTCCTTCATCCAGAGGGATCGCTTCAGCCGCTTCCAGCCCACCTACCCCTATGTG
CAGCACGAGATTGATCTTCCTCCCACCATCTCCCTGTCCGACGGTGAAGAGCCACCTCCTTACCAGGGGCCCTGCACCCTGCAGCTCCGGGACCCTGAAC
AGCAGATGGAACTCAACCGAGAGTCCGTGAGGGCCCCACCCAACCGAACCATATTTGACAGTGATTTAATAGACATTGCTATGTATAGCGGGGGTCCATG
CCCACCCAGCAGCAACTCGGGCATCAGTGCAAGCACCTGCAGCAGTAACGGGAGGATGGAGGGGCCACCCCCCACATACAGCGAGGTGATGGGCCACCAC
CCAGGCGCCTCTTTCCTCCATCACCAGCGCAGCAACGCACACAGGGGCAGCAGACTGCAGTTTCAGCAGAACAATGCAGAGAGCACAATAGTACCCATCA
AAGGCAAAGATAGGAAGCCTGGGAACCTGGTCTGATTCCTTCCAACGTGCACTTCAGCTGGAGAAAGAAACCAAGAAGGGAAGCGGCCGCTGGGCCCCTC
CTGCGCACAGTGTTGTTCAGTTTCACATGGTACAAATAAGTAAAACCAAATGAGCAAACACGGTCTTTGTTTCTGATTCCTTTTAGGGGAATTGCATGCA
AACTAGACTGAAATGATACAAACTTCCATCTGGTCTGACCGCAAACAGTGTTTATTTGGGGACAGGGGTTGGGATGGGGGTGTGGGCAGGGGAAAACAGA
GAACGGGATGCTTTGAAGATACCATGAAATAAAACCCACAGAGGTATTTGATGTATTTAATTGTGAAAGGAGACTTTGCAGATAAATGAGGCCAGAATGG
CATGTTTTATAATTAACTGAATAAAGAAGGAAGCATTATTATATATTATTGTGGGGAAGAACCAGCCAGTTCGCTTTTTCTCCTAAGGTGTGGAACTTTT
ATTTTGTTTTAAAAATATGAATCAAAATTCCTGTGTTGTGTGCCAAGGTATAAAGTGGAGAAGTTAGATGAGTGCAAGGAGCTCCTTTGTGTTGTGATGA
TGTGTTTTAAAAGTTGCACTATCTTAATGTTGAAAATATTTACAAGGGAACTGTTTTACGTGAAGTTCTGTATGTTGTCTTTTCACCTGTGGATTGTAAT
CAGGCCCAAGGAATATCCTGGAGTGGTCCCCAGAAGCATCCAAGAAAAGATATTTGGGGACGTAGCCTAACATTTTACCAACTTACGTAAATCAAAAAAG
TCATTATTGTTGCAGGAGTTTGCATCAAATAGCAGTGCATCGCTGAAGCTTTTGGAGACTTTTGGATGGAAGATAAGATAGGGAAGATTAAGTTCCAGCA
TTTCTGACTTGTTATTTTGAGTTACTCTGCTACTCTTAGGCTGCATAGTTTATGAGAAAATGAACACATGCATTTATGGATCCAGTATCATGCAGTGCTG
CCCTCATCCTCCAGCAGTGCAATTTCTTCAGTAATTTAGATTTTTTTCACTATAGCATGAAATATATTCAAATACATACCTTATTTTATGCAATAAATTG
TTTAAAATGCAAGGTGGTTATTCTGCATACTGTTGAAATATGTGACTCCTCAGTATATTCCCATTGCCTCTCCCCCTTTCCTCGACAGCTTAGTTCAGTT
CTGCAGGGCTGCTCAGTTCACAGGAGGCTCCCAGCAGCCACCCCACATCCAGCCTACACAGAACTTCGTGTGGGAGTGGTGTGGGTGGTGGTTTCTTATG
CTTTGGAAGCCCCTAGAAATAATGACGGAAGAATGCCATGTTGCTGATCGTGGTAATAAGCCATTGTGGGTTATTGTATGTCACTAGTATTAGCATAGCA
TTCTTAAAGGAATGCAGTGCTCAAAACCTACCCAAATTCCCGCAGGATTCTACCAAACCCTTCCCCAGGCCAGCTTTTGTACTGAAGGCAAGAACTGGAC
AGTCAGAGAACAGTGGAGGGGGCAAGTGACTGAAGAGCACCGGGTAAAAAGCACAACATGCAGTTAAAATGCAACTAGAAAACTAATTTTAAATATTGTT
AGTTTTAATATTCCTGATATTTACAAATATTCATTCTTATATACAATGAAAAAAATAACTTTCTTCTGCAGATGTAAGCACTGGCTTTTATAAGAGCAGC
AGCCAACACGTTTAGCAGACACTGCGCGTGGAGAAGGGCTTATCTGCAGTACACTCTGCCATGTGGAGGGTGGGCCTCTGTGGCCTCTTCACATAACAAG
ATGAGCTGGAATGATGATTCCATGACTCCCACCTATGCAGCCTTAAAGCCAAATCCGCGTGTGTGTGTTTGTGTCTGTCTGTGGGTCTCGAAGGTGATCC
GTCGGTGCGGTGGCTCTGTGCTGTAACTGGAGAGACTGTTCCAAACCCCAAGAGTTGTCTGATCCTAGTCTGTTCCCTTCTGCTTCTTACCTCTGTAGAT
AGGTCACTGGTTTTTGTTTGTTTGTTTTGAGGATTGGAATTTCCATTACATTCATCCTTTGCACACAGTAACATCCACAGAACTAGTCCAACTCTTAAAA
GGAGAGAGGAAAAACACAGGCACCAGTTGTCAGCTCATGCTTACAACCTGTGTGGAAGTATATACAGTTGAGAGTCACAGTGGAGGTTCTGAGACTGGAT
TCAGTCTTGTTCCAGTGACAGTTGGAAGGCCTCTGCTGGAGAGACACCAGCTCTCAGGGCAGAGATTGGCTTGGGGCCAGAAGGACCCTCCCCAACCCTG
GAGACACCCTGAAGGTTCACTGGCTCTCCAGATTAGCCTCTCTTCCTCTGTCAGGCAAAGATGAGGAGCCCGTGTTCCCATCGGGCCCTGCTGGCAGGGA
CTTGCAGTGGATTCTTGGTCAGGTGTGCCCACAGATGCGGAGGCGAGGTGAGTGATTCCATCATTTCAGTTCTCACCTGCAGTTTTGGTGAAGCAGGAGA
TGCACCCCACAGCTCTAGCTCTCAAATGGCTTCACAGTCCTTACTTCTCTACCTGCCTCAAGAAGGGGCTCAGAGCAGAGACTTGTGAATTCCTTAGTAA
CTGTGAGTATATGAATGTGTTGCACATGTCCACAGTATTGGCGAGATAATTACATAATTCAGATACCTTTAATCATCTTTCAAGAAAGAGGCTCCTCCCA
TTCAACCACCCTAGAGAACTGCCTTTGTTAAATAGTTATTTAAAGACTCATACATATCAAACCATGACTTTGAAAGGTCTTCGAGGCTGGGGCTCTGTAA
TGAATTAGTTTAAAAGCCAAGGTCATAACATGAATTGATGGTCAATTTCCCTTCAGCAGAAGGAAAAGGTGATTTAGATCAGTAGCTCTTTTGAAGGTTG
TGGCTGACCTGTTCATACCGTGTCGCCTCATGGCTAGTGTGGCGTTGAAAGAGTAGCGACTGGGAAGATACAACTTACACAGTGGGGCCTATTGTTCTTT
CAAGAACCCTTTTTTTAGCTTATAGAACCCATGGGTCCAGTTTAGTAACGAGTGATTTAGGCAATCAATGATAGGTTTATAATCTTAGATTATTCCAGCA
AAGTGTGGATTGCATTGTTAGGAAGAACATTTGGTGGGAATGAACACTCCTGGGCATACCGCTGACTTTTGTCCCTTGTTCCCGGTGTAGGAGACCCAAG
GCATCTTGAATCCCATCTATAAGAACACAATCTTCCAGCATACGTTTGCTTTTTCAGAAACTCTAGCATTCTCTTTAAATACTGACGCAATCCTTAATGG
AAAAGAGATTTCATGAAGCAAATTATGTATTTCAATAGTTCTTCTATTTTTAGTGTCCAAAATTTACTAATACAGAAGCTTGACAAGCATGTCCTCACCC
TCCCCACCACATAAACACATGGACACACACCCAAGCCACAAGAAATCCCAAGAGAGCAGAAGCGAATTTTTAAAAGATTTATCGTGAGGACTGCATTTCC
ATTCACTAATTTTGGCTCAAACTTATGAGGCAGGAAATAGGGGCCAACAGTAAATGGGGGAGGCCTCCTGACACCAGCAGAGGAATTTTGTACCCAGGCG
AGGACTTCTTGAACTTCTGCGTATCTCCGTTTGATCTCTTTCACCTTTATTTCATCTTCATAAGAATGAGAAAGGCTCAAAAGGAAGCACTTTTAGAAAT
CTTCTCTGACCTAGAAGAATCCATCCAAATCCCTGCCTTCCTCTCTGAACCAACAGTTCCCTTCTCTGACAGGGGCCATCCTCTATCTTCCATCCAGCGG
CTCTTCTTTTTAGGAAGGCTCTGGTGCAGAGCACTTCAAATATGTCCTCAGGCCAGATACTGATTGCTAGTAGAGAGACACCCGGCACCCAGTCCGAAGC
CCTCCCTCAAAGGACCGGCTCATGGCGTTGGTCACTGGCAGGCTCAGAGACATTCTGCTGTGGGCGCAGGGAGCCCGGCCCCCCATGCAGCCATGACTGG
ATGCGCCCCCATCTCGGGGGCTTGCTGCACTGCTTGTTTATTGAATTTTGCTACTTAGAATGGCAACATTAACTTTGTGTACCATTCATTTTTTAAAAAT
TTTCCAAAGCTCGGCAGTGTATGAAAGAAAAAACTGGGAAAGATACTTGGTTTCTGTTAACTTTTGTGTTGCTTGCTTAAGTGATTAAAGCCAGTGCTTG
GAGCCAAGCCTTCATGCCACGAACATGCTCCACAGCCTGCCCTTTGCTCTCCTGCTCACACTGACCAAGAATGCCGCGTGCTTGGCCTACTGAGGTGAAA
GGACAATTGAATGACAGGTGGGCAAAGGGAGAACTTCCCCTTCTTGGTGCGAGGAAAGTCACAAATTTAAAAATGTTGCTTCCAGCCCAGATCCTAAATG
CTAGTTCTCAGCAGCTGCGTGGCTTACCGTTCGCCATTTCCACCACCGCCAGCTGCCAGCACCGCTACAGATCACAGAGATGTGAACAGACAATGGAAAG
CACTCTTAGCCTTGCAGTGGTCTACATTTTTTAGGAACCAATATTTCAGCATTCTTTATTACCCGGCACGCTGTGTCCTTTGCAGAGTTCAAGTTTATGT
TACTGCCAGGGTCAGACAGTCATTTGCTGCTGCTGCTGCTGCTGCTGCTTCTCGAACTGGATGCATTAGGAAGCTGCTGTCTGAGTGTAGGAATGTCTTG
CTAAGAAAGCAATGTCTTCCTTCATCCTTTTCTTTCTTCCCTCTGCGTGTCCTTGTTTTTGTGTAATGCGGGAGAGGGTTAGAGCTATAGAGATTATATA
TACACTATCCGTGCACATTATATATATGTAGATATACCCCTATCATGTCAGAGATCTGCATGTCAGTTTTTCAGCAACTAAGGTGCCTCATGTTCTGAGT
TCAGCAGATATAGGAACCAAGCCGCCCCCTCCTGCACTTGATGCTCCCACCTTTGTTGTGCCTCACTTAAAATGGTGCTTTTTTCAGTTGTCTGTCTTTT
CTTATGTTTTTATTTGTAAGGTGCTGTATATAAGTTGAATATATTATGCACATATCCTACCCAATGGGTAGAACAAAAAGTTGTTAATACTGTAATATAA
TGTATAGATGATACCAATTTTAACAGAAATGGCATAGAATTTGTGAATGCCTATGTGCTTTGTCCTCTTTTGTAAGGAAATTTGCAAATGGATGCATACA
GATTAAAGTCTATGTAGTTTATTTTCCTATTAAATATCAATATTATAACACAAGAGAAAGAAGTGTGAACAAACAAGCAACAGTTTATGACCAGCGTATA
TATAGCAATGGAAAGTTGCATCTTTGCTGTGAAAACACTTTAAAGAAAATACTTTTTAAAAAATCCCACAGCTTTTTGGTTGCCACTAGACGCTTCTTAT
TTTAATCATTTTAGTAATGCTCAGCTGGACCAGTGTTAGTTATATTTGAGTCAGAAAAATGTTGTTTTTCAACTTGCTTTATAATCTCCTGCATCTATCT
CCTGCTGTAGCATCACGAAGGTGTCAGGCAACAGTGAAAAGTGCACATTTTTGTTGTTGCAGAAACTGTGTCAGAGGAATAAGTAAATCAGCCTGCAGCA
GAAGACTTTGTTCAGCTCCAGAGGCATCTGTGACCGTCTGTGTCCAAGTCTCTCTGTGCCTTTTTCTTTTACAAACTGAAGCTGTGGAGCCAATGAAGTA
ACAGTAGAGATTGTAGGGAAAGAATACCTCAGGAAAAACAAATACACTTACAAGAAGACCCTGTTCTTAGAAAATGTGTTTAGTTATGGGTTAGCACTAG
AAGAGACTTGGCTGTCAGCCAGCCAAGTGAAGGACCTCTCATCCATTCCCATTCATGTCCCATCATAATACGGACCCAAAAAGCAAACTCGGTTTTGCCA
TCAGTTAGAAATTACGTTTTGGATTGTATATTGTTACATCTCTCTTCCGGCTTAGTTTTTAGTGTCTGATTGTGACCTCTGCATTTATCTTCAAATACCC
TAATTTTAAAACAAAAGAACAAGAAAAGTTTATAACACCATGTTCACTAAAACCACGGTTGAATCTTGGGTGTGGGCATCCTTTCGAGTGTTGTCCATAA
GAGCAGTTCGTGGAATTTTGCCCATCTGACCCATATTATCAGCTTATTCTGCCACCAGAGTAGAGTCTAATAAATTCCAAAGTTTTTATTTGCTCCATGG
TGTATGTTCTGACTTTGAAAATGTCAGATTCTATAATCATACCCCTAACATCCAGGAAACAAATGACAGATTATCTTTAAACTGAAATTGACTCTACAAT
GCAACCCTTAATGCTGAATGGATTAAAAAAGTCAGCCCTTTTAGTATCTGTTTGAAAGGGCCGTAAAAAGTTGACACTTTTGTTGTTGTGGATCCTGCGT
GTCTAGACCCACGTGTTGTTTCCATCGTATACTGTAGGGTGCACCCCTTGGGATTCATCATTAAGAACTGAGGCTCACTGTTGTCAGAAACAAAGCTCCC
ACCCCCCAGGTTCAACCTTGTGGGAGAACTGTTGAGCATGAGAATGTTCTAGACTCAGAGGTACTAAAATTTGTTACCACATCATTGCTTCCTTTCTACA
GGACGAATTGAGGCTTAAACTTTACTGTTAATGATACTGGTTCATTTTAATGTGCTTGTTGGTATGTTGCTATTTTTCATTTCATAGCTTTCAAAAATCA
TGCTAATTGTATACTTGTCTAGTTTAAGGCTATTTTAAAATATGTACAATACTATTCACAGCATTTAGTTCGTTTAATTTTTATTATAAAGCAATCTACT
AAAAAAGTACAACTGTATTTGAACTTTTCAATAGTTGTTTGTGAGCTATGATAATCAAAAGTCATTAAAGTCTTTTTTAACAAACATTCGTGCTTACTTT
TCAACATAATTCCCAGTTATATACAGAAAAAGATTTCCACCTGTCACGTATCTGCCTCTTTTACCTGAGCAATGGTGTAGTTCTTAGACCTAAGGTCTGT
AATTGCAATACTTTTAAAGAAAGATGTTGCTCTAAGTGCTGTTTGTTAGTTATGAAATCAGATTTTTCTGCTTGTTCTTAATGCTGTGGTCAAACCATAG
CACAAAATCATTAAAAATAATCAGCGGCATAC
- refseq_C18orf1.F1 (forward primer)
- refseq_C18orf1.R1 (reverse primer)
- Single exon skipping
Frame 0
LSSLWWGMAEASRSPQLVCTASRLCRGVSFPKVGQSFLCPAGL*GTDVCERPSGPDGWGGDSAWRMG
GDWRGQVANHSPLPWQRSWSSPKSSSSSWWSR*
WWWSSSAC*TTTKSPRGPSSTARTRAGGGRTGC
RRSCMPRGPGTGSQRRPSSRGIASAASSPPTPMC
STRLIFLPPSPCPTVKSHLLTRGPAPCSSGTLN
SRWNSTESP*GPHPTEPYLTVI**TLLCIAGVH
AHPAATRASVQAPAAVTGGWRGHPPHTAR*WATT
QAPLSSITSAATHTGAADCSFSRTMQRAQ*YPS
KAKIGSLGTWSDSFQRALQLEKETKKGSGRWAP
PAHSVVQFHMVQISKTK*ANTVFVSDSF*GNCMQ
TRLK*YKLPSGLTANSVYLGTGVGMGVWAGENR
ERDALKIP*NKTHRGI*CI*L*KETLQINEARM
ACFIIN*IKKEALLYIIVGKNQPVRFFS*GVELL
FCFKNMNQNSCVVCQGIKWRS*MSARSSFVL**
CVLKVALS*C*KYLQGNCFT*SSVCCLFTCGL*
SGPRNILEWSPEASKKRYLGT*PNILPTYVNQKS
HYCCRSLHQIAVHR*SFWRLLDGR*DRED*VPA
FLTCYFELLCYS*AA*FMRK*THAFMDPVSCSA
ALILQQCNFFSNLDFFHYSMKYIQIHTLFYAINC
LKCKVVILHTVEICDSSVYSHCLSPFPRQLSSV
LQGCSVHRRLPAATPHPAYTELRVGVVWVVVSY
ALEAPRNNDGRMPCC*SW**AIVGYCMSLVLA*H
S*RNAVLKTYPNSRRILPNPSPGQLLY*RQELD
SQRTVEGASD*RAPGKKHNMQLKCN*KTNFKYC
*F*YS*YLQIFILIYNEKNNFLLQM*ALAFIRAA
ANTFSRHCAWRRAYLQYTLPCGGWASVASSHNK
MSWNDDSMTPTYAALKPNPRVCVCVCLWVSKVI
RRCGGSVL*LERLFQTPRVV*S*SVPFCFLPL*I
GHWFLFVCFEDWNFHYIHPLHTVTSTELVQLLK
GERKNTGTSCQLMLTTCVEVYTVESHSGGSETG
FSLVPVTVGRPLLERHQLSGQRLAWGQKDPPQPW
RHPEGSLALQISLSSSVRQR*GARVPIGPCWQG
LAVDSWSGVPTDAEAR*VIPSFQFSPAVLVKQE
MHPTALALKWLHSPYFSTCLKKGLRAETCEFLSN
CEYMNVLHMSTVLAR*LHNSDTFNHLSRKRLLP
FNHPRELPLLNSYLKTHTYQTMTLKGLRGWGSV
MN*FKSQGHNMN*WSISLQQKEKVI*ISSSFEGC
G*PVHTVSPHG*CGVERVATGKIQLTQWGLLFF
QEPFF*LIEPMGPV**RVI*AINDRFIILDYSS
KVWIALLGRTFGGNEHSWAYR*LLSLVPGVGDPR
HLESHL*EHNLPAYVCFFRNSSILFKY*RNP*W
KRDFMKQIMYFNSSSIFSVQNLLIQKLDKHVLT
LPTT*THGHTPKPQEIPREQKRIFKRFIVRTAFP
FTNFGSNL*GRK*GPTVNGGGLLTPAEEFCTQA
RTS*TSAYLRLISFTFISSS*E*ERLKRKHF*K
SSLT*KNPSKSLPSSLNQQFPSLTGAILYLPSSG
SSF*EGSGAEHFKYVLRPDTDC**RDTRHPVRS
PPSKDRLMALVTGRLRDILLWAQGARPPMQP*L
DAPPSRGLAALLVY*ILLLRMATLTLCTIHFLKI
FQSSAVYERKNWERYLVSVNFCVACLSD*SQCL
EPSLHATNMLHSLPFALLLTLTKNAACLAY*GE
RTIE*QVGKGRTSPSWCEESHKFKNVASSPDPKC
*FSAAAWLTVRHFHHRQLPAPLQITEM*TDNGK
HS*PCSGLHFLGTNISAFFITRHAVSFAEFKFM
LLPGSDSHLLLLLLLLLLELDALGSCCLSVGMSC
*ESNVFLHPFLSSLCVSLFLCNAGEG*SYRDYI
YTIRAHYIYVDIPLSCQRSACQFFSN*GASCSE
FSRYRNQAAPSCT*CSHLCCASLKMVLFSVVCLF
LCFYL*GAVYKLNILCTYPTQWVEQKVVNTVI*
CIDDTNFNRNGIEFVNAYVLCPLL*GNLQMDAY
RLKSM*FIFLLNINIITQEKEV*TNKQQFMTSVY
IAMESCIFAVKTL*RKYFLKNPTAFWLPLDASY
FNHFSNAQLDQC*LYLSQKNVVFQLAL*SPASI
SCCSITKVSGNSEKCTFLLLQKLCQRNK*ISLQQ
KTLFSSRGICDRLCPSLSVPFSFTN*SCGANEV
TVEIVGKEYLRKNKYTYKKTLFLENVFSYGLAL
EETWLSASQVKDLSSIPIHVPS*YGPKKQTRFCH
QLEITFWIVYCYISLPA*FLVSDCDLCIYLQIP
*F*NKRTRKVYNTMFTKTTVESWVWASFRVLSI
RAVRGILPI*PILSAYSATRVESNKFQSFYLLHG
VCSDFENVRFYNHTPNIQETNDRLSLN*N*LYN
ATLNAEWIKKVSPFSICLKGP*KVDTFVVVDPA
CLDPRVVSIVYCRVHPLGFIIKN*GSLLSETKLP
PPRFNLVGELLSMRMF*TQRY*NLLPHHCFLST
GRIEA*TLLLMILVHFNVLVGMLLFFIS*LSKI
MLIVYLSSLRLF*NMYNTIHSI*FV*FLL*SNLL
KKYNCI*TFQ*LFVSYDNQKSLKSFLTNIRAYF
ST*FPVIYRKRFPPVTYLPLLPEQWCSS*T*GL
*LQYF*RKMLL*VLFVSYEIRFFCLFLMLWSNHS
TKSLKIISGI
Frame 1
SAPCGGGWQRLPAPRSWFAQPPDCAVVSPSLKWDSRFCVLLASEEQTCVRGLQGLMAGVVTVPGEW
VGTGGARWLTTLLFHGSGAGVRPNHHHRRGGHGD
GGGHRLPAEPLQSLHAVLHQPPEPEPEAGGRAA
ADHACPAVQGQVHSAVLHPEGSLQPLPAHLPLC
AARD*SSSHHLPVRR*RATSLPGALHPAAPGP*T
ADGTQPRVREGPTQPNHI*Q*FNRHCYV*RGSM
PTQQQLGHQCKHLQQ*REDGGATPHIQRGDGPP
PRRLFPPSPAQQRTQGQQTAVSAEQCREHNSTHQ
RQR*EAWEPGLIPSNVHFSWRKKPRREAAAGPL
LRTVLFSFTWYK*VKPNEQTRSLFLIPFRGIAC
KLD*NDTNFHLV*PQTVFIWGQGLGWGCGQGKTE
NGML*RYHEIKPTEVFDVFNCERRLCR*MRPEW
HVL*LTE*RRKHYYILLWGRTSQFAFSPKVWNF
YFVLKI*IKIPVLCAKV*SGEVR*VQGAPLCCDD
VF*KLHYLNVENIYKGTVLREVLYVVFSPVDCN
QAQGISWSGPQKHPRKDIWGRSLTFYQLT*IKK
VIIVAGVCIK*QCIAEAFGDFWMEDKIGKIKFQH
F*LVILSYSATLRLHSL*ENEHMHLWIQYHAVL
PSSSSSAISSVI*IFFTIA*NIFKYIPYFMQ*I
V*NARWLFCILLKYVTPQYIPIASPPFLDSLVQF
CRAAQFTGGSQQPPHIQPTQNFVWEWCGWWFLM
LWKPLEIMTEECHVADRGNKPLWVIVCH*Y*HS
ILKGMQCSKPTQIPAGFYQTLPQASFCTEGKNWT
VREQWRGQVTEEHRVKSTTCS*NATRKLILNIV
SFNIPDIYKYSFLYTMKKITFFCRCKHWLL*EQ
QPTRLADTARGEGLICSTLCHVEGGPLWPLHITR
*AGMMIP*LPPMQP*SQIRVCVFVSVCGSRR*S
VGAVALCCNWRDCSKPQELSDPSLFPSASYLCR
*VTGFCLFVLRIGISITFILCTQ*HPQN*SNS*K
ERGKTQAPVVSSCLQPVWKYIQLRVTVEVLRLD
SVLFQ*QLEGLCWRDTSSQGRDWLGARRTLPNP
GDTLKVHWLSRLASLPLSGKDEEPVFPSGPAGRD
LQWILGQVCPQMRRRGE*FHHFSSHLQFW*SRR
CTPQL*LSNGFTVLTSLPASRRGSEQRLVNSLV
TVSI*MCCTCPQYWRDNYIIQIPLIIFQERGSSH
STTLENCLC*IVI*RLIHIKP*L*KVFEAGAL*
*ISLKAKVIT*IDGQFPFSRRKR*FRSVALLKV
VADLFIPCRLMASVALKE*RLGRYNLHSGAYCSF
KNPFFSL*NPWVQFSNE*FRQSMIGL*S*IIPA
KCGLHC*EEHLVGMNTPGHTADFCPLFPV*ETQ
GILNPIYKNTIFQHTFAFSETLAFSLNTDAILNG
KEIS*SKLCISIVLLFLVSKIY*YRSLTSMSSP
SPPHKHMDTHPSHKKSQESRSEFLKDLS*GLHF
HSLILAQTYEAGNRGQQ*MGEAS*HQQRNFVPRR
GLLELLRISV*SLSPLFHLHKNEKGSKGSTFRN
LL*PRRIHPNPCLPL*TNSSLL*QGPSSIFHPA
ALLFRKALVQSTSNMSSGQILIASRETPGTQSEA
LPQRTGSWRWSLAGSETFCCGRREPGPPCSHDW
MRPHLGGLLHCLFIEFCYLEWQH*LCVPFIF*K
FSKARQCMKEKTGKDTWFLLTFVLLA*VIKASAW
SQAFMPRTCSTACPLLSCSH*PRMPRAWPTEVK
GQLNDRWAKGELPLLGARKVTNLKMLLPAQILN
ASSQQLRGLPFAISTTASCQHRYRSQRCEQTMES
TLSLAVVYIF*EPIFQHSLLPGTLCPLQSSSLC
YCQGQTVICCCCCCCCFSNWMH*EAAV*V*ECL
AKKAMSSFILFFLPSACPCFCVMRERVRAIEIIY
TLSVHIIYM*IYPYHVRDLHVSFSATKVPHVLS
SADIGTKPPPPALDAPTFVVPHLKWCFFQLSVF
SYVFICKVLYIS*IYYAHILPNG*NKKLLIL*YN
V*MIPILTEMA*NL*MPMCFVLFCKEICKWMHT
D*SLCSLFSY*ISIL*HKRKKCEQTSNSL*PAY
I*QWKVASLL*KHFKENTF*KIPQLFGCH*TLLI
LIILVMLSWTSVSYI*VRKMLFFNLLYNLLHLS
PAVASRRCQATVKSAHFCCCRNCVRGISKSACS
RRLCSAPEASVTVCVQVSLCLFLLQTEAVEPMK*
Q*RL*GKNTSGKTNTLTRRPCS*KMCLVMG*H*
KRLGCQPAK*RTSHPFPFMSHHNTDPKSKLGFA
IS*KLRFGLYIVTSLFRLSF*CLIVTSAFIFKYP
NFKTKEQEKFITPCSLKPRLNLGCGHPFECCP*
EQFVEFCPSDPYYQLILPPE*SLINSKVFICSM
VYVLTLKMSDSIIIPLTSRKQMTDYL*TEIDSTM
QPLMLNGLKKSALLVSV*KGRKKLTLLLLWILR
V*THVLFPSYTVGCTPWDSSLRTEAHCCQKQSS
HPPGSTLWENC*A*ECSRLRGTKICYHIIASFLQ
DELRLKLYC**YWFILMCLLVCCYFSFHSFQKS
C*LYTCLV*GYFKICTILFTAFSSFNFYYKAIY
*KSTTVFELFNSCL*AMIIKSH*SLF*QTFVLTF
QHNSQLYTEKDFHLSRICLFYLSNGVVLRPKVC
NCNTFKERCCSKCCLLVMKSDFSACS*CCGQTI
AQNH*K*SAAY
Frame 2
QLPVVGDGRGFPLPAAGLHSLPTVPWCLLP*SGTVVSVSCWPLRNRRV*EAFRA*WLGW*QCLENG
WGLEGPGG*PLSSSMAAELEFAQIIIIVVVVTV
MVVVIVCLLNHYKVSTRSFINRPNQSRRREDGLP
QIMHAPRSRDRFTAPSFIQRDRFSRFQPTYPYV
QHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPE
QQMELNRESVRAPPNRTIFDSDLIDIAMYSGGPC
PPSSNSGISASTCSSNGRMEGPPPTYSEVMGHH
PGASFLHHQRSNAHRGSRLQFQQNNAESTIVPI
KGKDRKPGNLV*FLPTCTSAGERNQEGKRPLGPS
CAQCCSVSHGTNK*NQMSKHGLCF*FLLGELHA
N*TEMIQTSIWSDRKQCLFGDRGWDGGVGRGKQ
RTGCFEDTMK*NPQRYLMYLIVKGDFADK*GQNG
MFYN*LNKEGSIIIYYCGEEPASSLFLLRCGTF
ILF*KYESKFLCCVPRYKVEKLDECKELLCVVM
MCFKSCTILMLKIFTRELFYVKFCMLSFHLWIVI
RPKEYPGVVPRSIQEKIFGDVA*HFTNLRKSKK
SLLLQEFASNSSASLKLLETFGWKIR*GRLSSS
ISDLLF*VTLLLLGCIVYEKMNTCIYGSSIMQCC
PHPPAVQFLQ*FRFFSL*HEIYSNTYLILCNKL
FKMQGGYSAYC*NM*LLSIFPLPLPLSSTA*FS
SAGLLSSQEAPSSHPTSSLHRTSCGSGVGGGFLC
FGSP*K**RKNAMLLIVVISHCGLLYVTSISIA
FLKECSAQNLPKFPQDSTKPFPRPAFVLKARTG
QSENSGGGK*LKSTG*KAQHAVKMQLEN*F*ILL
VLIFLIFTNIHSYIQ*KK*LSSADVSTGFYKSS
SQHV*QTLRVEKGLSAVHSAMWRVGLCGLFT*Q
DELE**FHDSHLCSLKAKSACVCLCLSVGLEGDP
SVRWLCAVTGETVPNPKSCLILVCSLLLLTSVD
RSLVFVCLF*GLEFPLHSSFAHSNIHRTSPTLK
RREEKHRHQLSAHAYNLCGSIYS*ESQWRF*DWI
QSCSSDSWKASAGETPALRAEIGLGPEGPSPTL
ETP*RFTGSPD*PLFLCQAKMRSPCSHRALLAG
TCSGFLVRCAHRCGGEVSDSIISVLTCSFGEAGD
APHSSSSQMASQSLLLYLPQEGAQSRDL*IP**
L*VYECVAHVHSIGEIIT*FRYL*SSFKKEAPP
IQPP*RTAFVK*LFKDSYISNHDFERSSRLGLCN
ELV*KPRS*HELMVNFPSAEGKGDLDQ*LF*RL
WLTCSYRVASWLVWR*KSSDWEDTTYTVGPIVL
SRTLFLAYRTHGSSLVTSDLGNQ**VYNLRLFQQ
SVDCIVRKNIWWE*TLLGIPLTFVPCSRCRRPK
AS*IPSIRTQSSSIRLLFQKL*HSL*ILTQSLM
EKRFHEANYVFQ*FFYF*CPKFTNTEA*QACPHP
PHHINTWTHTQATRNPKRAEANF*KIYREDCIS
IH*FWLKLMRQEIGANSKWGRPPDTSRGILYPG
EDFLNFCVSPFDLFHLYFIFIRMRKAQKEALLEI
FSDLEESIQIPAFLSEPTVPFSDRGHPLSSIQR
LFFLGRLWCRALQICPQARY*LLVERHPAPSPK
PSLKGPAHGVGHWQAQRHSAVGAGSPAPHAAMTG
CAPISGACCTACLLNFAT*NGNINFVYHSFFKN
FPKLGSV*KKKLGKILGFC*LLCCLLK*LKPVL
GAKPSCHEHAPQPALCSPAHTDQECRVLGLLR*K
DN*MTGGQRENFPFLVRGKSQI*KCCFQPRS*M
LVLSSCVAYRSPFPPPPAASTATDHRDVNRQWK
ALLALQWSTFFRNQYFSILYYPARCVLCRVQVYV
TARVRQSFAAAAAAAASRTGCIRKLLSECRNVL
LRKQCLPSSFSFFPLRVLVFV*CGRGLEL*RLY
IHYPCTLYICRYTPIMSEICMSVFQQLRCLMF*V
QQI*EPSRPLLHLMLPPLLCLT*NGAFFSCLSF
LMFLFVRCCI*VEYIMHISYPMGRTKSC*YCNI
MYR*YQF*QKWHRICECLCALSSFVRKFANGCIQ
IKVYVVYFPIKYQYYNTRERSVNKQATVYDQRI
YSNGKLHLCCENTLKKILFKKSHSFLVATRRFL
F*SF**CSAGPVLVIFESEKCCFSTCFIISCIYL
LL*HHEGVRQQ*KVHIFVVAETVSEE*VNQPAA
EDFVQLQRHL*PSVSKSLCAFFFYKLKLWSQ*S
NSRDCRERIPQEKQIHLQEDPVLRKCV*LWVSTR
RDLAVSQPSEGPLIHSHSCPIIIRTQKANSVLP
SVRNYVLDCILLHLSSGLVFSV*L*PLHLSSNT
LILKQKNKKSL*HHVH*NHG*ILGVGILSSVVHK
SSSWNFAHLTHIISLFCHQSRV**IPKFLFAPW
CMF*L*KCQIL*SYP*HPGNK*QIIFKLKLTLQ
CNP*C*MD*KSQPF*YLFERAVKS*HFCCCGSCV
SRPTCCFHRIL*GAPLGIHH*ELRLTVVRNKAP
TPQVQPCGRTVEHENVLDSEVLKFVTTSLLPFY
RTN*GLNFTVNDTGSF*CACWYVAIFHFIAFKNH
ANCILV*FKAILKYVQYYSQHLVRLIFIIKQST
KKVQLYLNFSIVVCEL**SKVIKVFFNKHSCLL
FNIIPSYIQKKISTCHVSASFT*AMV*FLDLRSV
IAILLKKDVALSAVC*L*NQIFLLVLNAVVKP*
HKIIKNNQRH
Sequence NM_004338
CTCAGCTCCCTGTGGTGGGGGATGGCAGAGGCTTCCCGCTCCCCGCAGCTGGTTTGCACAGCCTCCCGACTGTGCCGTGGTGTCTCCTTCCCTAAAGTGGGACAGTCGTTTCTGTGTCCTGCTGGCCTCTGAGGAACAGACGTGTGTGAGAGGCCTTCAGGGCCTGATGGCTGGGGTGGTGACAGTGCCTGGAGAATGGG
TGGGGACTGGAGGGGCCAGGTGGCTAACCACTCTCCTCTTCCATGGCAGCGGAGCTGGAGTTCGCCCAAATCATCATCATCGTCGTGGTGGTCACGGTGA
TGGTGGTGGTCATCGTCTGCCTGCTGAACCACTACAAAGTCTCCACGCGGTCCTTCATCAACCGCCCGAACCAGAGCCGGAGGCGGGAGGACGGGCTGCC
GCAGGAAGGGTGCCTGTGGCCTTCAGACAGCGCCGCACCGCGGCTGGGCGCCTCGGAGATCATGCATGCCCCGCGGTCCAGGGACAGGTTCACAGCGCCG
TCCTTCATCCAGAGGGATCGCTTCAGCCGCTTCCAGCCCACCTACCCCTATGTGCAGCACGAGATTGATCTTCCTCCCACCATCTCCCTGTCCGACGGTG
AAGAGCCACCTCCTTACCAGGGGCCCTGCACCCTGCAGCTCCGGGACCCTGAACAGCAGATGGAACTCAACCGAGAGTCCGTGAGGGCCCCACCCAACCG
AACCATATTTGACAGTGATTTAATAGACATTGCTATGTATAGCGGGGGTCCATGCCCACCCAGCAGCAACTCGGGCATCAGTGCAAGCACCTGCAGCAGT
AACGGGAGGATGGAGGGGCCACCCCCCACATACAGCGAGGTGATGGGCCACCACCCAGGCGCCTCTTTCCTCCATCACCAGCGCAGCAACGCACACAGGG
GCAGCAGACTGCAGTTTCAGCAGAACAATGCAGAGAGCACAATAGTACCCATCAAAGGCAAAGATAGGAAGCCTGGGAACCTGGTCTGATTCCTTCCAAC
GTGCACTTCAGCTGGAGAAAGAAACCAAGAAGGGAAGCGGCCGCTGGGCCCCTCCTGCGCACAGTGTTGTTCAGTTTCACATGGTACAAATAAGTAAAAC
CAAATGAGCAAACACGGTCTTTGTTTCTGATTCCTTTTAGGGGAATTGCATGCAAACTAGACTGAAATGATACAAACTTCCATCTGGTCTGACCGCAAAC
AGTGTTTATTTGGGGACAGGGGTTGGGATGGGGGTGTGGGCAGGGGAAAACAGAGAACGGGATGCTTTGAAGATACCATGAAATAAAACCCACAGAGGTA
TTTGATGTATTTAATTGTGAAAGGAGACTTTGCAGATAAATGAGGCCAGAATGGCATGTTTTATAATTAACTGAATAAAGAAGGAAGCATTATTATATAT
TATTGTGGGGAAGAACCAGCCAGTTCGCTTTTTCTCCTAAGGTGTGGAACTTTTATTTTGTTTTAAAAATATGAATCAAAATTCCTGTGTTGTGTGCCAA
GGTATAAAGTGGAGAAGTTAGATGAGTGCAAGGAGCTCCTTTGTGTTGTGATGATGTGTTTTAAAAGTTGCACTATCTTAATGTTGAAAATATTTACAAG
GGAACTGTTTTACGTGAAGTTCTGTATGTTGTCTTTTCACCTGTGGATTGTAATCAGGCCCAAGGAATATCCTGGAGTGGTCCCCAGAAGCATCCAAGAA
AAGATATTTGGGGACGTAGCCTAACATTTTACCAACTTACGTAAATCAAAAAAGTCATTATTGTTGCAGGAGTTTGCATCAAATAGCAGTGCATCGCTGA
AGCTTTTGGAGACTTTTGGATGGAAGATAAGATAGGGAAGATTAAGTTCCAGCATTTCTGACTTGTTATTTTGAGTTACTCTGCTACTCTTAGGCTGCAT
AGTTTATGAGAAAATGAACACATGCATTTATGGATCCAGTATCATGCAGTGCTGCCCTCATCCTCCAGCAGTGCAATTTCTTCAGTAATTTAGATTTTTT
TCACTATAGCATGAAATATATTCAAATACATACCTTATTTTATGCAATAAATTGTTTAAAATGCAAGGTGGTTATTCTGCATACTGTTGAAATATGTGAC
TCCTCAGTATATTCCCATTGCCTCTCCCCCTTTCCTCGACAGCTTAGTTCAGTTCTGCAGGGCTGCTCAGTTCACAGGAGGCTCCCAGCAGCCACCCCAC
ATCCAGCCTACACAGAACTTCGTGTGGGAGTGGTGTGGGTGGTGGTTTCTTATGCTTTGGAAGCCCCTAGAAATAATGACGGAAGAATGCCATGTTGCTG
ATCGTGGTAATAAGCCATTGTGGGTTATTGTATGTCACTAGTATTAGCATAGCATTCTTAAAGGAATGCAGTGCTCAAAACCTACCCAAATTCCCGCAGG
ATTCTACCAAACCCTTCCCCAGGCCAGCTTTTGTACTGAAGGCAAGAACTGGACAGTCAGAGAACAGTGGAGGGGGCAAGTGACTGAAGAGCACCGGGTA
AAAAGCACAACATGCAGTTAAAATGCAACTAGAAAACTAATTTTAAATATTGTTAGTTTTAATATTCCTGATATTTACAAATATTCATTCTTATATACAA
TGAAAAAAATAACTTTCTTCTGCAGATGTAAGCACTGGCTTTTATAAGAGCAGCAGCCAACACGTTTAGCAGACACTGCGCGTGGAGAAGGGCTTATCTG
CAGTACACTCTGCCATGTGGAGGGTGGGCCTCTGTGGCCTCTTCACATAACAAGATGAGCTGGAATGATGATTCCATGACTCCCACCTATGCAGCCTTAA
AGCCAAATCCGCGTGTGTGTGTTTGTGTCTGTCTGTGGGTCTCGAAGGTGATCCGTCGGTGCGGTGGCTCTGTGCTGTAACTGGAGAGACTGTTCCAAAC
CCCAAGAGTTGTCTGATCCTAGTCTGTTCCCTTCTGCTTCTTACCTCTGTAGATAGGTCACTGGTTTTTGTTTGTTTGTTTTGAGGATTGGAATTTCCAT
TACATTCATCCTTTGCACACAGTAACATCCACAGAACTAGTCCAACTCTTAAAAGGAGAGAGGAAAAACACAGGCACCAGTTGTCAGCTCATGCTTACAA
CCTGTGTGGAAGTATATACAGTTGAGAGTCACAGTGGAGGTTCTGAGACTGGATTCAGTCTTGTTCCAGTGACAGTTGGAAGGCCTCTGCTGGAGAGACA
CCAGCTCTCAGGGCAGAGATTGGCTTGGGGCCAGAAGGACCCTCCCCAACCCTGGAGACACCCTGAAGGTTCACTGGCTCTCCAGATTAGCCTCTCTTCC
TCTGTCAGGCAAAGATGAGGAGCCCGTGTTCCCATCGGGCCCTGCTGGCAGGGACTTGCAGTGGATTCTTGGTCAGGTGTGCCCACAGATGCGGAGGCGA
GGTGAGTGATTCCATCATTTCAGTTCTCACCTGCAGTTTTGGTGAAGCAGGAGATGCACCCCACAGCTCTAGCTCTCAAATGGCTTCACAGTCCTTACTT
CTCTACCTGCCTCAAGAAGGGGCTCAGAGCAGAGACTTGTGAATTCCTTAGTAACTGTGAGTATATGAATGTGTTGCACATGTCCACAGTATTGGCGAGA
TAATTACATAATTCAGATACCTTTAATCATCTTTCAAGAAAGAGGCTCCTCCCATTCAACCACCCTAGAGAACTGCCTTTGTTAAATAGTTATTTAAAGA
CTCATACATATCAAACCATGACTTTGAAAGGTCTTCGAGGCTGGGGCTCTGTAATGAATTAGTTTAAAAGCCAAGGTCATAACATGAATTGATGGTCAAT
TTCCCTTCAGCAGAAGGAAAAGGTGATTTAGATCAGTAGCTCTTTTGAAGGTTGTGGCTGACCTGTTCATACCGTGTCGCCTCATGGCTAGTGTGGCGTT
GAAAGAGTAGCGACTGGGAAGATACAACTTACACAGTGGGGCCTATTGTTCTTTCAAGAACCCTTTTTTTAGCTTATAGAACCCATGGGTCCAGTTTAGT
AACGAGTGATTTAGGCAATCAATGATAGGTTTATAATCTTAGATTATTCCAGCAAAGTGTGGATTGCATTGTTAGGAAGAACATTTGGTGGGAATGAACA
CTCCTGGGCATACCGCTGACTTTTGTCCCTTGTTCCCGGTGTAGGAGACCCAAGGCATCTTGAATCCCATCTATAAGAACACAATCTTCCAGCATACGTT
TGCTTTTTCAGAAACTCTAGCATTCTCTTTAAATACTGACGCAATCCTTAATGGAAAAGAGATTTCATGAAGCAAATTATGTATTTCAATAGTTCTTCTA
TTTTTAGTGTCCAAAATTTACTAATACAGAAGCTTGACAAGCATGTCCTCACCCTCCCCACCACATAAACACATGGACACACACCCAAGCCACAAGAAAT
CCCAAGAGAGCAGAAGCGAATTTTTAAAAGATTTATCGTGAGGACTGCATTTCCATTCACTAATTTTGGCTCAAACTTATGAGGCAGGAAATAGGGGCCA
ACAGTAAATGGGGGAGGCCTCCTGACACCAGCAGAGGAATTTTGTACCCAGGCGAGGACTTCTTGAACTTCTGCGTATCTCCGTTTGATCTCTTTCACCT
TTATTTCATCTTCATAAGAATGAGAAAGGCTCAAAAGGAAGCACTTTTAGAAATCTTCTCTGACCTAGAAGAATCCATCCAAATCCCTGCCTTCCTCTCT
GAACCAACAGTTCCCTTCTCTGACAGGGGCCATCCTCTATCTTCCATCCAGCGGCTCTTCTTTTTAGGAAGGCTCTGGTGCAGAGCACTTCAAATATGTC
CTCAGGCCAGATACTGATTGCTAGTAGAGAGACACCCGGCACCCAGTCCGAAGCCCTCCCTCAAAGGACCGGCTCATGGCGTTGGTCACTGGCAGGCTCA
GAGACATTCTGCTGTGGGCGCAGGGAGCCCGGCCCCCCATGCAGCCATGACTGGATGCGCCCCCATCTCGGGGGCTTGCTGCACTGCTTGTTTATTGAAT
TTTGCTACTTAGAATGGCAACATTAACTTTGTGTACCATTCATTTTTTAAAAATTTTCCAAAGCTCGGCAGTGTATGAAAGAAAAAACTGGGAAAGATAC
TTGGTTTCTGTTAACTTTTGTGTTGCTTGCTTAAGTGATTAAAGCCAGTGCTTGGAGCCAAGCCTTCATGCCACGAACATGCTCCACAGCCTGCCCTTTG
CTCTCCTGCTCACACTGACCAAGAATGCCGCGTGCTTGGCCTACTGAGGTGAAAGGACAATTGAATGACAGGTGGGCAAAGGGAGAACTTCCCCTTCTTG
GTGCGAGGAAAGTCACAAATTTAAAAATGTTGCTTCCAGCCCAGATCCTAAATGCTAGTTCTCAGCAGCTGCGTGGCTTACCGTTCGCCATTTCCACCAC
CGCCAGCTGCCAGCACCGCTACAGATCACAGAGATGTGAACAGACAATGGAAAGCACTCTTAGCCTTGCAGTGGTCTACATTTTTTAGGAACCAATATTT
CAGCATTCTTTATTACCCGGCACGCTGTGTCCTTTGCAGAGTTCAAGTTTATGTTACTGCCAGGGTCAGACAGTCATTTGCTGCTGCTGCTGCTGCTGCT
GCTTCTCGAACTGGATGCATTAGGAAGCTGCTGTCTGAGTGTAGGAATGTCTTGCTAAGAAAGCAATGTCTTCCTTCATCCTTTTCTTTCTTCCCTCTGC
GTGTCCTTGTTTTTGTGTAATGCGGGAGAGGGTTAGAGCTATAGAGATTATATATACACTATCCGTGCACATTATATATATGTAGATATACCCCTATCAT
GTCAGAGATCTGCATGTCAGTTTTTCAGCAACTAAGGTGCCTCATGTTCTGAGTTCAGCAGATATAGGAACCAAGCCGCCCCCTCCTGCACTTGATGCTC
CCACCTTTGTTGTGCCTCACTTAAAATGGTGCTTTTTTCAGTTGTCTGTCTTTTCTTATGTTTTTATTTGTAAGGTGCTGTATATAAGTTGAATATATTA
TGCACATATCCTACCCAATGGGTAGAACAAAAAGTTGTTAATACTGTAATATAATGTATAGATGATACCAATTTTAACAGAAATGGCATAGAATTTGTGA
ATGCCTATGTGCTTTGTCCTCTTTTGTAAGGAAATTTGCAAATGGATGCATACAGATTAAAGTCTATGTAGTTTATTTTCCTATTAAATATCAATATTAT
AACACAAGAGAAAGAAGTGTGAACAAACAAGCAACAGTTTATGACCAGCGTATATATAGCAATGGAAAGTTGCATCTTTGCTGTGAAAACACTTTAAAGA
AAATACTTTTTAAAAAATCCCACAGCTTTTTGGTTGCCACTAGACGCTTCTTATTTTAATCATTTTAGTAATGCTCAGCTGGACCAGTGTTAGTTATATT
TGAGTCAGAAAAATGTTGTTTTTCAACTTGCTTTATAATCTCCTGCATCTATCTCCTGCTGTAGCATCACGAAGGTGTCAGGCAACAGTGAAAAGTGCAC
ATTTTTGTTGTTGCAGAAACTGTGTCAGAGGAATAAGTAAATCAGCCTGCAGCAGAAGACTTTGTTCAGCTCCAGAGGCATCTGTGACCGTCTGTGTCCA
AGTCTCTCTGTGCCTTTTTCTTTTACAAACTGAAGCTGTGGAGCCAATGAAGTAACAGTAGAGATTGTAGGGAAAGAATACCTCAGGAAAAACAAATACA
CTTACAAGAAGACCCTGTTCTTAGAAAATGTGTTTAGTTATGGGTTAGCACTAGAAGAGACTTGGCTGTCAGCCAGCCAAGTGAAGGACCTCTCATCCAT
TCCCATTCATGTCCCATCATAATACGGACCCAAAAAGCAAACTCGGTTTTGCCATCAGTTAGAAATTACGTTTTGGATTGTATATTGTTACATCTCTCTT
CCGGCTTAGTTTTTAGTGTCTGATTGTGACCTCTGCATTTATCTTCAAATACCCTAATTTTAAAACAAAAGAACAAGAAAAGTTTATAACACCATGTTCA
CTAAAACCACGGTTGAATCTTGGGTGTGGGCATCCTTTCGAGTGTTGTCCATAAGAGCAGTTCGTGGAATTTTGCCCATCTGACCCATATTATCAGCTTA
TTCTGCCACCAGAGTAGAGTCTAATAAATTCCAAAGTTTTTATTTGCTCCATGGTGTATGTTCTGACTTTGAAAATGTCAGATTCTATAATCATACCCCT
AACATCCAGGAAACAAATGACAGATTATCTTTAAACTGAAATTGACTCTACAATGCAACCCTTAATGCTGAATGGATTAAAAAAGTCAGCCCTTTTAGTA
TCTGTTTGAAAGGGCCGTAAAAAGTTGACACTTTTGTTGTTGTGGATCCTGCGTGTCTAGACCCACGTGTTGTTTCCATCGTATACTGTAGGGTGCACCC
CTTGGGATTCATCATTAAGAACTGAGGCTCACTGTTGTCAGAAACAAAGCTCCCACCCCCCAGGTTCAACCTTGTGGGAGAACTGTTGAGCATGAGAATG
TTCTAGACTCAGAGGTACTAAAATTTGTTACCACATCATTGCTTCCTTTCTACAGGACGAATTGAGGCTTAAACTTTACTGTTAATGATACTGGTTCATT
TTAATGTGCTTGTTGGTATGTTGCTATTTTTCATTTCATAGCTTTCAAAAATCATGCTAATTGTATACTTGTCTAGTTTAAGGCTATTTTAAAATATGTA
CAATACTATTCACAGCATTTAGTTCGTTTAATTTTTATTATAAAGCAATCTACTAAAAAAGTACAACTGTATTTGAACTTTTCAATAGTTGTTTGTGAGC
TATGATAATCAAAAGTCATTAAAGTCTTTTTTAACAAACATTCGTGCTTACTTTTCAACATAATTCCCAGTTATATACAGAAAAAGATTTCCACCTGTCA
CGTATCTGCCTCTTTTACCTGAGCAATGGTGTAGTTCTTAGACCTAAGGTCTGTAATTGCAATACTTTTAAAGAAAGATGTTGCTCTAAGTGCTGTTTGT
TAGTTATGAAATCAGATTTTTCTGCTTGTTCTTAATGCTGTGGTCAAACCATAGCACAAAATCATTAAAAATAATCAGCGGCATAC
- refseq_C18orf1.F1 (forward primer)
- refseq_C18orf1.R1 (reverse primer)
- Single exon skipping
Frame 0
LSSLWWGMAEASRSPQLVCTASRLCRGVSFPKVGQSFLCPAGL*GTDVCERPSGPDGWGGDSAWRMG
GDWRGQVANHSPLPWQRSWSSPKSSSSSWWSR*
WWWSSSAC*TTTKSPRGPSSTARTRAGGGRTGC
RRKGACGLQTAPHRGWAPRRSCMPRGPGTGSQRR
PSSRGIASAASSPPTPMCSTRLIFLPPSPCPTV
KSHLLTRGPAPCSSGTLNSRWNSTESP*GPHPT
EPYLTVI**TLLCIAGVHAHPAATRASVQAPAAV
TGGWRGHPPHTAR*WATTQAPLSSITSAATHTG
AADCSFSRTMQRAQ*YPSKAKIGSLGTWSDSFQ
RALQLEKETKKGSGRWAPPAHSVVQFHMVQISKT
K*ANTVFVSDSF*GNCMQTRLK*YKLPSGLTAN
SVYLGTGVGMGVWAGENRERDALKIP*NKTHRG
I*CI*L*KETLQINEARMACFIIN*IKKEALLYI
IVGKNQPVRFFS*GVELLFCFKNMNQNSCVVCQ
GIKWRS*MSARSSFVL**CVLKVALS*C*KYLQ
GNCFT*SSVCCLFTCGL*SGPRNILEWSPEASKK
RYLGT*PNILPTYVNQKSHYCCRSLHQIAVHR*
SFWRLLDGR*DRED*VPAFLTCYFELLCYS*AA
*FMRK*THAFMDPVSCSAALILQQCNFFSNLDFF
HYSMKYIQIHTLFYAINCLKCKVVILHTVEICD
SSVYSHCLSPFPRQLSSVLQGCSVHRRLPAATP
HPAYTELRVGVVWVVVSYALEAPRNNDGRMPCC*
SW**AIVGYCMSLVLA*HS*RNAVLKTYPNSRR
ILPNPSPGQLLY*RQELDSQRTVEGASD*RAPG
KKHNMQLKCN*KTNFKYC*F*YS*YLQIFILIYN
EKNNFLLQM*ALAFIRAAANTFSRHCAWRRAYL
QYTLPCGGWASVASSHNKMSWNDDSMTPTYAAL
KPNPRVCVCVCLWVSKVIRRCGGSVL*LERLFQT
PRVV*S*SVPFCFLPL*IGHWFLFVCFEDWNFH
YIHPLHTVTSTELVQLLKGERKNTGTSCQLMLT
TCVEVYTVESHSGGSETGFSLVPVTVGRPLLERH
QLSGQRLAWGQKDPPQPWRHPEGSLALQISLSS
SVRQR*GARVPIGPCWQGLAVDSWSGVPTDAEA
R*VIPSFQFSPAVLVKQEMHPTALALKWLHSPYF
STCLKKGLRAETCEFLSNCEYMNVLHMSTVLAR
*LHNSDTFNHLSRKRLLPFNHPRELPLLNSYLK
THTYQTMTLKGLRGWGSVMN*FKSQGHNMN*WSI
SLQQKEKVI*ISSSFEGCG*PVHTVSPHG*CGV
ERVATGKIQLTQWGLLFFQEPFF*LIEPMGPV*
*RVI*AINDRFIILDYSSKVWIALLGRTFGGNEH
SWAYR*LLSLVPGVGDPRHLESHL*EHNLPAYV
CFFRNSSILFKY*RNP*WKRDFMKQIMYFNSSS
IFSVQNLLIQKLDKHVLTLPTT*THGHTPKPQEI
PREQKRIFKRFIVRTAFPFTNFGSNL*GRK*GP
TVNGGGLLTPAEEFCTQARTS*TSAYLRLISFT
FISSS*E*ERLKRKHF*KSSLT*KNPSKSLPSSL
NQQFPSLTGAILYLPSSGSSF*EGSGAEHFKYV
LRPDTDC**RDTRHPVRSPPSKDRLMALVTGRL
RDILLWAQGARPPMQP*LDAPPSRGLAALLVY*I
LLLRMATLTLCTIHFLKIFQSSAVYERKNWERY
LVSVNFCVACLSD*SQCLEPSLHATNMLHSLPF
ALLLTLTKNAACLAY*GERTIE*QVGKGRTSPSW
CEESHKFKNVASSPDPKC*FSAAAWLTVRHFHH
RQLPAPLQITEM*TDNGKHS*PCSGLHFLGTNI
SAFFITRHAVSFAEFKFMLLPGSDSHLLLLLLLL
LLELDALGSCCLSVGMSC*ESNVFLHPFLSSLC
VSLFLCNAGEG*SYRDYIYTIRAHYIYVDIPLS
CQRSACQFFSN*GASCSEFSRYRNQAAPSCT*CS
HLCCASLKMVLFSVVCLFLCFYL*GAVYKLNIL
CTYPTQWVEQKVVNTVI*CIDDTNFNRNGIEFV
NAYVLCPLL*GNLQMDAYRLKSM*FIFLLNINII
TQEKEV*TNKQQFMTSVYIAMESCIFAVKTL*R
KYFLKNPTAFWLPLDASYFNHFSNAQLDQC*LY
LSQKNVVFQLAL*SPASISCCSITKVSGNSEKCT
FLLLQKLCQRNK*ISLQQKTLFSSRGICDRLCP
SLSVPFSFTN*SCGANEVTVEIVGKEYLRKNKY
TYKKTLFLENVFSYGLALEETWLSASQVKDLSSI
PIHVPS*YGPKKQTRFCHQLEITFWIVYCYISL
PA*FLVSDCDLCIYLQIP*F*NKRTRKVYNTMF
TKTTVESWVWASFRVLSIRAVRGILPI*PILSAY
SATRVESNKFQSFYLLHGVCSDFENVRFYNHTP
NIQETNDRLSLN*N*LYNATLNAEWIKKVSPFS
ICLKGP*KVDTFVVVDPACLDPRVVSIVYCRVHP
LGFIIKN*GSLLSETKLPPPRFNLVGELLSMRM
F*TQRY*NLLPHHCFLSTGRIEA*TLLLMILVH
FNVLVGMLLFFIS*LSKIMLIVYLSSLRLF*NMY
NTIHSI*FV*FLL*SNLLKKYNCI*TFQ*LFVS
YDNQKSLKSFLTNIRAYFST*FPVIYRKRFPPV
TYLPLLPEQWCSS*T*GL*LQYF*RKMLL*VLFV
SYEIRFFCLFLMLWSNHSTKSLKIISGI
Frame 1
SAPCGGGWQRLPAPRSWFAQPPDCAVVSPSLKWDSRFCVLLASEEQTCVRGLQGLMAGVVTVPGEW
VGTGGARWLTTLLFHGSGAGVRPNHHHRRGGHGD
GGGHRLPAEPLQSLHAVLHQPPEPEPEAGGRAA
AGRVPVAFRQRRTAAGRLGDHACPAVQGQVHSA
VLHPEGSLQPLPAHLPLCAARD*SSSHHLPVRR*
RATSLPGALHPAAPGP*TADGTQPRVREGPTQP
NHI*Q*FNRHCYV*RGSMPTQQQLGHQCKHLQQ
*REDGGATPHIQRGDGPPPRRLFPPSPAQQRTQG
QQTAVSAEQCREHNSTHQRQR*EAWEPGLIPSN
VHFSWRKKPRREAAAGPLLRTVLFSFTWYK*VK
PNEQTRSLFLIPFRGIACKLD*NDTNFHLV*PQT
VFIWGQGLGWGCGQGKTENGML*RYHEIKPTEV
FDVFNCERRLCR*MRPEWHVL*LTE*RRKHYYI
LLWGRTSQFAFSPKVWNFYFVLKI*IKIPVLCAK
V*SGEVR*VQGAPLCCDDVF*KLHYLNVENIYK
GTVLREVLYVVFSPVDCNQAQGISWSGPQKHPR
KDIWGRSLTFYQLT*IKKVIIVAGVCIK*QCIAE
AFGDFWMEDKIGKIKFQHF*LVILSYSATLRLH
SL*ENEHMHLWIQYHAVLPSSSSSAISSVI*IF
FTIA*NIFKYIPYFMQ*IV*NARWLFCILLKYVT
PQYIPIASPPFLDSLVQFCRAAQFTGGSQQPPH
IQPTQNFVWEWCGWWFLMLWKPLEIMTEECHVA
DRGNKPLWVIVCH*Y*HSILKGMQCSKPTQIPAG
FYQTLPQASFCTEGKNWTVREQWRGQVTEEHRV
KSTTCS*NATRKLILNIVSFNIPDIYKYSFLYT
MKKITFFCRCKHWLL*EQQPTRLADTARGEGLIC
STLCHVEGGPLWPLHITR*AGMMIP*LPPMQP*
SQIRVCVFVSVCGSRR*SVGAVALCCNWRDCSK
PQELSDPSLFPSASYLCR*VTGFCLFVLRIGISI
TFILCTQ*HPQN*SNS*KERGKTQAPVVSSCLQ
PVWKYIQLRVTVEVLRLDSVLFQ*QLEGLCWRD
TSSQGRDWLGARRTLPNPGDTLKVHWLSRLASLP
LSGKDEEPVFPSGPAGRDLQWILGQVCPQMRRR
GE*FHHFSSHLQFW*SRRCTPQL*LSNGFTVLT
SLPASRRGSEQRLVNSLVTVSI*MCCTCPQYWRD
NYIIQIPLIIFQERGSSHSTTLENCLC*IVI*R
LIHIKP*L*KVFEAGAL**ISLKAKVIT*IDGQ
FPFSRRKR*FRSVALLKVVADLFIPCRLMASVAL
KE*RLGRYNLHSGAYCSFKNPFFSL*NPWVQFS
NE*FRQSMIGL*S*IIPAKCGLHC*EEHLVGMN
TPGHTADFCPLFPV*ETQGILNPIYKNTIFQHTF
AFSETLAFSLNTDAILNGKEIS*SKLCISIVLL
FLVSKIY*YRSLTSMSSPSPPHKHMDTHPSHKK
SQESRSEFLKDLS*GLHFHSLILAQTYEAGNRGQ
Q*MGEAS*HQQRNFVPRRGLLELLRISV*SLSP
LFHLHKNEKGSKGSTFRNLL*PRRIHPNPCLPL
*TNSSLL*QGPSSIFHPAALLFRKALVQSTSNMS
SGQILIASRETPGTQSEALPQRTGSWRWSLAGS
ETFCCGRREPGPPCSHDWMRPHLGGLLHCLFIE
FCYLEWQH*LCVPFIF*KFSKARQCMKEKTGKDT
WFLLTFVLLA*VIKASAWSQAFMPRTCSTACPL
LSCSH*PRMPRAWPTEVKGQLNDRWAKGELPLL
GARKVTNLKMLLPAQILNASSQQLRGLPFAISTT
ASCQHRYRSQRCEQTMESTLSLAVVYIF*EPIF
QHSLLPGTLCPLQSSSLCYCQGQTVICCCCCCC
CFSNWMH*EAAV*V*ECLAKKAMSSFILFFLPSA
CPCFCVMRERVRAIEIIYTLSVHIIYM*IYPYH
VRDLHVSFSATKVPHVLSSADIGTKPPPPALDA
PTFVVPHLKWCFFQLSVFSYVFICKVLYIS*IYY
AHILPNG*NKKLLIL*YNV*MIPILTEMA*NL*
MPMCFVLFCKEICKWMHTD*SLCSLFSY*ISIL
*HKRKKCEQTSNSL*PAYI*QWKVASLL*KHFKE
NTF*KIPQLFGCH*TLLILIILVMLSWTSVSYI
*VRKMLFFNLLYNLLHLSPAVASRRCQATVKSA
HFCCCRNCVRGISKSACSRRLCSAPEASVTVCVQ
VSLCLFLLQTEAVEPMK*Q*RL*GKNTSGKTNT
LTRRPCS*KMCLVMG*H*KRLGCQPAK*RTSHP
FPFMSHHNTDPKSKLGFAIS*KLRFGLYIVTSLF
RLSF*CLIVTSAFIFKYPNFKTKEQEKFITPCS
LKPRLNLGCGHPFECCP*EQFVEFCPSDPYYQL
ILPPE*SLINSKVFICSMVYVLTLKMSDSIIIPL
TSRKQMTDYL*TEIDSTMQPLMLNGLKKSALLV
SV*KGRKKLTLLLLWILRV*THVLFPSYTVGCT
PWDSSLRTEAHCCQKQSSHPPGSTLWENC*A*EC
SRLRGTKICYHIIASFLQDELRLKLYC**YWFI
LMCLLVCCYFSFHSFQKSC*LYTCLV*GYFKIC
TILFTAFSSFNFYYKAIY*KSTTVFELFNSCL*A
MIIKSH*SLF*QTFVLTFQHNSQLYTEKDFHLS
RICLFYLSNGVVLRPKVCNCNTFKERCCSKCCL
LVMKSDFSACS*CCGQTIAQNH*K*SAAY
Frame 2
QLPVVGDGRGFPLPAAGLHSLPTVPWCLLP*SGTVVSVSCWPLRNRRV*EAFRA*WLGW*QCLENG
WGLEGPGG*PLSSSMAAELEFAQIIIIVVVVTV
MVVVIVCLLNHYKVSTRSFINRPNQSRRREDGLP
QEGCLWPSDSAAPRLGASEIMHAPRSRDRFTAP
SFIQRDRFSRFQPTYPYVQHEIDLPPTISLSDG
EEPPPYQGPCTLQLRDPEQQMELNRESVRAPPNR
TIFDSDLIDIAMYSGGPCPPSSNSGISASTCSS
NGRMEGPPPTYSEVMGHHPGASFLHHQRSNAHR
GSRLQFQQNNAESTIVPIKGKDRKPGNLV*FLPT
CTSAGERNQEGKRPLGPSCAQCCSVSHGTNK*N
QMSKHGLCF*FLLGELHAN*TEMIQTSIWSDRK
QCLFGDRGWDGGVGRGKQRTGCFEDTMK*NPQRY
LMYLIVKGDFADK*GQNGMFYN*LNKEGSIIIY
YCGEEPASSLFLLRCGTFILF*KYESKFLCCVP
RYKVEKLDECKELLCVVMMCFKSCTILMLKIFTR
ELFYVKFCMLSFHLWIVIRPKEYPGVVPRSIQE
KIFGDVA*HFTNLRKSKKSLLLQEFASNSSASL
KLLETFGWKIR*GRLSSSISDLLF*VTLLLLGCI
VYEKMNTCIYGSSIMQCCPHPPAVQFLQ*FRFF
SL*HEIYSNTYLILCNKLFKMQGGYSAYC*NM*
LLSIFPLPLPLSSTA*FSSAGLLSSQEAPSSHPT
SSLHRTSCGSGVGGGFLCFGSP*K**RKNAMLL
IVVISHCGLLYVTSISIAFLKECSAQNLPKFPQ
DSTKPFPRPAFVLKARTGQSENSGGGK*LKSTG*
KAQHAVKMQLEN*F*ILLVLIFLIFTNIHSYIQ
*KK*LSSADVSTGFYKSSSQHV*QTLRVEKGLS
AVHSAMWRVGLCGLFT*QDELE**FHDSHLCSLK
AKSACVCLCLSVGLEGDPSVRWLCAVTGETVPN
PKSCLILVCSLLLLTSVDRSLVFVCLF*GLEFP
LHSSFAHSNIHRTSPTLKRREEKHRHQLSAHAYN
LCGSIYS*ESQWRF*DWIQSCSSDSWKASAGET
PALRAEIGLGPEGPSPTLETP*RFTGSPD*PLF
LCQAKMRSPCSHRALLAGTCSGFLVRCAHRCGGE
VSDSIISVLTCSFGEAGDAPHSSSSQMASQSLL
LYLPQEGAQSRDL*IP**L*VYECVAHVHSIGE
IIT*FRYL*SSFKKEAPPIQPP*RTAFVK*LFKD
SYISNHDFERSSRLGLCNELV*KPRS*HELMVN
FPSAEGKGDLDQ*LF*RLWLTCSYRVASWLVWR
*KSSDWEDTTYTVGPIVLSRTLFLAYRTHGSSLV
TSDLGNQ**VYNLRLFQQSVDCIVRKNIWWE*T
LLGIPLTFVPCSRCRRPKAS*IPSIRTQSSSIR
LLFQKL*HSL*ILTQSLMEKRFHEANYVFQ*FFY
F*CPKFTNTEA*QACPHPPHHINTWTHTQATRN
PKRAEANF*KIYREDCISIH*FWLKLMRQEIGA
NSKWGRPPDTSRGILYPGEDFLNFCVSPFDLFHL
YFIFIRMRKAQKEALLEIFSDLEESIQIPAFLS
EPTVPFSDRGHPLSSIQRLFFLGRLWCRALQIC
PQARY*LLVERHPAPSPKPSLKGPAHGVGHWQAQ
RHSAVGAGSPAPHAAMTGCAPISGACCTACLLN
FAT*NGNINFVYHSFFKNFPKLGSV*KKKLGKI
LGFC*LLCCLLK*LKPVLGAKPSCHEHAPQPALC
SPAHTDQECRVLGLLR*KDN*MTGGQRENFPFL
VRGKSQI*KCCFQPRS*MLVLSSCVAYRSPFPP
PPAASTATDHRDVNRQWKALLALQWSTFFRNQYF
SILYYPARCVLCRVQVYVTARVRQSFAAAAAAA
ASRTGCIRKLLSECRNVLLRKQCLPSSFSFFPL
RVLVFV*CGRGLEL*RLYIHYPCTLYICRYTPIM
SEICMSVFQQLRCLMF*VQQI*EPSRPLLHLML
PPLLCLT*NGAFFSCLSFLMFLFVRCCI*VEYI
MHISYPMGRTKSC*YCNIMYR*YQF*QKWHRICE
CLCALSSFVRKFANGCIQIKVYVVYFPIKYQYY
NTRERSVNKQATVYDQRIYSNGKLHLCCENTLK
KILFKKSHSFLVATRRFLF*SF**CSAGPVLVIF
ESEKCCFSTCFIISCIYLLL*HHEGVRQQ*KVH
IFVVAETVSEE*VNQPAAEDFVQLQRHL*PSVS
KSLCAFFFYKLKLWSQ*SNSRDCRERIPQEKQIH
LQEDPVLRKCV*LWVSTRRDLAVSQPSEGPLIH
SHSCPIIIRTQKANSVLPSVRNYVLDCILLHLS
SGLVFSV*L*PLHLSSNTLILKQKNKKSL*HHVH
*NHG*ILGVGILSSVVHKSSSWNFAHLTHIISL
FCHQSRV**IPKFLFAPWCMF*L*KCQIL*SYP
*HPGNK*QIIFKLKLTLQCNP*C*MD*KSQPF*Y
LFERAVKS*HFCCCGSCVSRPTCCFHRIL*GAP
LGIHH*ELRLTVVRNKAPTPQVQPCGRTVEHEN
VLDSEVLKFVTTSLLPFYRTN*GLNFTVNDTGSF
*CACWYVAIFHFIAFKNHANCILV*FKAILKYV
QYYSQHLVRLIFIIKQSTKKVQLYLNFSIVVCE
L**SKVIKVFFNKHSCLLFNIIPSYIQKKISTCH
VSASFT*AMV*FLDLRSVIAILLKKDVALSAVC
*L*NQIFLLVLNAVVKP*HKIIKNNQRH
Sequence NM_001003674
GGAACATTGAGCATCCTGACTTTGAAGGAGTCTCTGTGGTGTTTTTGTGCTACCATACATGGGGAATAATGATGTGAGGCAGAGGGAGAGGGAATGAATGGGAGAGCCAAGAGGGAAGAGCGAGCCGGGGGGAAAGGAGCGCGCAGTGTTTCCTGCTGCGGTTAGGACCTCACGCCTTGCCAGTACAGAGCTCGGTGGCA
AGAGCCGCTGGGAGCTGCTCCCATCAGTTAGAGGATGTGGAGAGGGAGCACCAGAAGAGGACAGCCCGCAGCCTGGCTCGCAGCCTGAGGGACGCTGTGG
GTGCTCCCAGCCGGGCGAGCACGCTCTGGGAGCGGATCTGCAGGGGAGAAGCACGCGAGCCTAACGTGAGCGTCCCGCCTGTCGCGTGTCCTGCCTTGGT
AAGCGCCCTCTCCGGTCCTTCCACACTGAAAGCTTCCAGCAGAGATCAAGGGAAGGAGTATTGTGTGAGACTTGCAGATTTCCTCCTTTCTGTCTGGACT
GGTTTGATATTTGCCTGTTGAAAAGATTACTGAACGCAGTGTGACAAGATGAGCCGTCTAGCTGCGTTCTGCTTGCCTGTGTGTGTGACACGTCCAGGTG
TGAGGCCAAACCTGAGAAGTGCAGACTGCTCACTGATAGACGTTGCTGTAAACAGTAGTGCCCTGGGTGTACAGCTGGTCTCAGGATCGGAGACCCCGGA
CTTATTCTCTGCTCGGTGACACGGCCGGCTTCCTGCCGCAGAGCTCCTGGTTTCTGTTGATGGCAGTTGATAATTGGTAGCCACAGTCTGCGGTCGGAGC
CACAGCATTTGAGTCTAGCACCTGGGGTGGGCCCTGCTGATACAGTAGAGAGAGAGTGAACGAGGCAGACAGAAACACACCCCCCCCCCCTCCACGCTCA
CACACTCTCCCACACCCCATGCCAGCTATAACTGCAGCTCTGAGCTGCCTGGAGAGGAGATTGCCGGAAGCTGAAGGGATGCTTTGAACGTGGGGGGGCT
GCGTCACAGTTGGACTCCCACTTGCAGAGGACCTGATTATGTCCAGTGACCACCTGAACAACAGCACACTGAAGGAGGCTCAGTTCAAAGACCTGTTCTT
AAAAAAAGCGGAGCTGGAGTTCGCCCAAATCATCATCATCGTCGTGGTGGTCACGGTGATGGTGGTGGTCATCGTCTGCCTGCTGAACCACTACAAAGTC
TCCACGCGGTCCTTCATCAACCGCCCGAACCAGAGCCGGAGGCGGGAGGACGGGCTGCCGCAGGAAGGGTGCCTGTGGCCTTCAGACAGCGCCGCACCGC
GGCTGGGCGCCTCGGAGATCATGCATGCCCCGCGGTCCAGGGACAGGTTCACAGCGCCGTCCTTCATCCAGAGGGATCGCTTCAGCCGCTTCCAGCCCAC
CTACCCCTATGTGCAGCACGAGATTGATCTTCCTCCCACCATCTCCCTGTCCGACGGTGAAGAGCCACCTCCTTACCAGGGGCCCTGCACCCTGCAGCTC
CGGGACCCTGAACAGCAGATGGAACTCAACCGAGAGTCCGTGAGGGCCCCACCCAACCGAACCATATTTGACAGTGATTTAATAGACATTGCTATGTATA
GCGGGGGTCCATGCCCACCCAGCAGCAACTCGGGCATCAGTGCAAGCACCTGCAGCAGTAACGGGAGGATGGAGGGGCCACCCCCCACATACAGCGAGGT
GATGGGCCACCACCCAGGCGCCTCTTTCCTCCATCACCAGCGCAGCAACGCACACAGGGGCAGCAGACTGCAGTTTCAGCAGAACAATGCAGAGAGCACA
ATAGTACCCATCAAAGGCAAAGATAGGAAGCCTGGGAACCTGGTCTGATTCCTTCCAACGTGCACTTCAGCTGGAGAAAGAAACCAAGAAGGGAAGCGGC
CGCTGGGCCCCTCCTGCGCACAGTGTTGTTCAGTTTCACATGGTACAAATAAGTAAAACCAAATGAGCAAACACGGTCTTTGTTTCTGATTCCTTTTAGG
GGAATTGCATGCAAACTAGACTGAAATGATACAAACTTCCATCTGGTCTGACCGCAAACAGTGTTTATTTGGGGACAGGGGTTGGGATGGGGGTGTGGGC
AGGGGAAAACAGAGAACGGGATGCTTTGAAGATACCATGAAATAAAACCCACAGAGGTATTTGATGTATTTAATTGTGAAAGGAGACTTTGCAGATAAAT
GAGGCCAGAATGGCATGTTTTATAATTAACTGAATAAAGAAGGAAGCATTATTATATATTATTGTGGGGAAGAACCAGCCAGTTCGCTTTTTCTCCTAAG
GTGTGGAACTTTTATTTTGTTTTAAAAATATGAATCAAAATTCCTGTGTTGTGTGCCAAGGTATAAAGTGGAGAAGTTAGATGAGTGCAAGGAGCTCCTT
TGTGTTGTGATGATGTGTTTTAAAAGTTGCACTATCTTAATGTTGAAAATATTTACAAGGGAACTGTTTTACGTGAAGTTCTGTATGTTGTCTTTTCACC
TGTGGATTGTAATCAGGCCCAAGGAATATCCTGGAGTGGTCCCCAGAAGCATCCAAGAAAAGATATTTGGGGACGTAGCCTAACATTTTACCAACTTACG
TAAATCAAAAAAGTCATTATTGTTGCAGGAGTTTGCATCAAATAGCAGTGCATCGCTGAAGCTTTTGGAGACTTTTGGATGGAAGATAAGATAGGGAAGA
TTAAGTTCCAGCATTTCTGACTTGTTATTTTGAGTTACTCTGCTACTCTTAGGCTGCATAGTTTATGAGAAAATGAACACATGCATTTATGGATCCAGTA
TCATGCAGTGCTGCCCTCATCCTCCAGCAGTGCAATTTCTTCAGTAATTTAGATTTTTTTCACTATAGCATGAAATATATTCAAATACATACCTTATTTT
ATGCAATAAATTGTTTAAAATGCAAGGTGGTTATTCTGCATACTGTTGAAATATGTGACTCCTCAGTATATTCCCATTGCCTCTCCCCCTTTCCTCGACA
GCTTAGTTCAGTTCTGCAGGGCTGCTCAGTTCACAGGAGGCTCCCAGCAGCCACCCCACATCCAGCCTACACAGAACTTCGTGTGGGAGTGGTGTGGGTG
GTGGTTTCTTATGCTTTGGAAGCCCCTAGAAATAATGACGGAAGAATGCCATGTTGCTGATCGTGGTAATAAGCCATTGTGGGTTATTGTATGTCACTAG
TATTAGCATAGCATTCTTAAAGGAATGCAGTGCTCAAAACCTACCCAAATTCCCGCAGGATTCTACCAAACCCTTCCCCAGGCCAGCTTTTGTACTGAAG
GCAAGAACTGGACAGTCAGAGAACAGTGGAGGGGGCAAGTGACTGAAGAGCACCGGGTAAAAAGCACAACATGCAGTTAAAATGCAACTAGAAAACTAAT
TTTAAATATTGTTAGTTTTAATATTCCTGATATTTACAAATATTCATTCTTATATACAATGAAAAAAATAACTTTCTTCTGCAGATGTAAGCACTGGCTT
TTATAAGAGCAGCAGCCAACACGTTTAGCAGACACTGCGCGTGGAGAAGGGCTTATCTGCAGTACACTCTGCCATGTGGAGGGTGGGCCTCTGTGGCCTC
TTCACATAACAAGATGAGCTGGAATGATGATTCCATGACTCCCACCTATGCAGCCTTAAAGCCAAATCCGCGTGTGTGTGTTTGTGTCTGTCTGTGGGTC
TCGAAGGTGATCCGTCGGTGCGGTGGCTCTGTGCTGTAACTGGAGAGACTGTTCCAAACCCCAAGAGTTGTCTGATCCTAGTCTGTTCCCTTCTGCTTCT
TACCTCTGTAGATAGGTCACTGGTTTTTGTTTGTTTGTTTTGAGGATTGGAATTTCCATTACATTCATCCTTTGCACACAGTAACATCCACAGAACTAGT
CCAACTCTTAAAAGGAGAGAGGAAAAACACAGGCACCAGTTGTCAGCTCATGCTTACAACCTGTGTGGAAGTATATACAGTTGAGAGTCACAGTGGAGGT
TCTGAGACTGGATTCAGTCTTGTTCCAGTGACAGTTGGAAGGCCTCTGCTGGAGAGACACCAGCTCTCAGGGCAGAGATTGGCTTGGGGCCAGAAGGACC
CTCCCCAACCCTGGAGACACCCTGAAGGTTCACTGGCTCTCCAGATTAGCCTCTCTTCCTCTGTCAGGCAAAGATGAGGAGCCCGTGTTCCCATCGGGCC
CTGCTGGCAGGGACTTGCAGTGGATTCTTGGTCAGGTGTGCCCACAGATGCGGAGGCGAGGTGAGTGATTCCATCATTTCAGTTCTCACCTGCAGTTTTG
GTGAAGCAGGAGATGCACCCCACAGCTCTAGCTCTCAAATGGCTTCACAGTCCTTACTTCTCTACCTGCCTCAAGAAGGGGCTCAGAGCAGAGACTTGTG
AATTCCTTAGTAACTGTGAGTATATGAATGTGTTGCACATGTCCACAGTATTGGCGAGATAATTACATAATTCAGATACCTTTAATCATCTTTCAAGAAA
GAGGCTCCTCCCATTCAACCACCCTAGAGAACTGCCTTTGTTAAATAGTTATTTAAAGACTCATACATATCAAACCATGACTTTGAAAGGTCTTCGAGGC
TGGGGCTCTGTAATGAATTAGTTTAAAAGCCAAGGTCATAACATGAATTGATGGTCAATTTCCCTTCAGCAGAAGGAAAAGGTGATTTAGATCAGTAGCT
CTTTTGAAGGTTGTGGCTGACCTGTTCATACCGTGTCGCCTCATGGCTAGTGTGGCGTTGAAAGAGTAGCGACTGGGAAGATACAACTTACACAGTGGGG
CCTATTGTTCTTTCAAGAACCCTTTTTTTAGCTTATAGAACCCATGGGTCCAGTTTAGTAACGAGTGATTTAGGCAATCAATGATAGGTTTATAATCTTA
GATTATTCCAGCAAAGTGTGGATTGCATTGTTAGGAAGAACATTTGGTGGGAATGAACACTCCTGGGCATACCGCTGACTTTTGTCCCTTGTTCCCGGTG
TAGGAGACCCAAGGCATCTTGAATCCCATCTATAAGAACACAATCTTCCAGCATACGTTTGCTTTTTCAGAAACTCTAGCATTCTCTTTAAATACTGACG
CAATCCTTAATGGAAAAGAGATTTCATGAAGCAAATTATGTATTTCAATAGTTCTTCTATTTTTAGTGTCCAAAATTTACTAATACAGAAGCTTGACAAG
CATGTCCTCACCCTCCCCACCACATAAACACATGGACACACACCCAAGCCACAAGAAATCCCAAGAGAGCAGAAGCGAATTTTTAAAAGATTTATCGTGA
GGACTGCATTTCCATTCACTAATTTTGGCTCAAACTTATGAGGCAGGAAATAGGGGCCAACAGTAAATGGGGGAGGCCTCCTGACACCAGCAGAGGAATT
TTGTACCCAGGCGAGGACTTCTTGAACTTCTGCGTATCTCCGTTTGATCTCTTTCACCTTTATTTCATCTTCATAAGAATGAGAAAGGCTCAAAAGGAAG
CACTTTTAGAAATCTTCTCTGACCTAGAAGAATCCATCCAAATCCCTGCCTTCCTCTCTGAACCAACAGTTCCCTTCTCTGACAGGGGCCATCCTCTATC
TTCCATCCAGCGGCTCTTCTTTTTAGGAAGGCTCTGGTGCAGAGCACTTCAAATATGTCCTCAGGCCAGATACTGATTGCTAGTAGAGAGACACCCGGCA
CCCAGTCCGAAGCCCTCCCTCAAAGGACCGGCTCATGGCGTTGGTCACTGGCAGGCTCAGAGACATTCTGCTGTGGGCGCAGGGAGCCCGGCCCCCCATG
CAGCCATGACTGGATGCGCCCCCATCTCGGGGGCTTGCTGCACTGCTTGTTTATTGAATTTTGCTACTTAGAATGGCAACATTAACTTTGTGTACCATTC
ATTTTTTAAAAATTTTCCAAAGCTCGGCAGTGTATGAAAGAAAAAACTGGGAAAGATACTTGGTTTCTGTTAACTTTTGTGTTGCTTGCTTAAGTGATTA
AAGCCAGTGCTTGGAGCCAAGCCTTCATGCCACGAACATGCTCCACAGCCTGCCCTTTGCTCTCCTGCTCACACTGACCAAGAATGCCGCGTGCTTGGCC
TACTGAGGTGAAAGGACAATTGAATGACAGGTGGGCAAAGGGAGAACTTCCCCTTCTTGGTGCGAGGAAAGTCACAAATTTAAAAATGTTGCTTCCAGCC
CAGATCCTAAATGCTAGTTCTCAGCAGCTGCGTGGCTTACCGTTCGCCATTTCCACCACCGCCAGCTGCCAGCACCGCTACAGATCACAGAGATGTGAAC
AGACAATGGAAAGCACTCTTAGCCTTGCAGTGGTCTACATTTTTTAGGAACCAATATTTCAGCATTCTTTATTACCCGGCACGCTGTGTCCTTTGCAGAG
TTCAAGTTTATGTTACTGCCAGGGTCAGACAGTCATTTGCTGCTGCTGCTGCTGCTGCTGCTTCTCGAACTGGATGCATTAGGAAGCTGCTGTCTGAGTG
TAGGAATGTCTTGCTAAGAAAGCAATGTCTTCCTTCATCCTTTTCTTTCTTCCCTCTGCGTGTCCTTGTTTTTGTGTAATGCGGGAGAGGGTTAGAGCTA
TAGAGATTATATATACACTATCCGTGCACATTATATATATGTAGATATACCCCTATCATGTCAGAGATCTGCATGTCAGTTTTTCAGCAACTAAGGTGCC
TCATGTTCTGAGTTCAGCAGATATAGGAACCAAGCCGCCCCCTCCTGCACTTGATGCTCCCACCTTTGTTGTGCCTCACTTAAAATGGTGCTTTTTTCAG
TTGTCTGTCTTTTCTTATGTTTTTATTTGTAAGGTGCTGTATATAAGTTGAATATATTATGCACATATCCTACCCAATGGGTAGAACAAAAAGTTGTTAA
TACTGTAATATAATGTATAGATGATACCAATTTTAACAGAAATGGCATAGAATTTGTGAATGCCTATGTGCTTTGTCCTCTTTTGTAAGGAAATTTGCAA
ATGGATGCATACAGATTAAAGTCTATGTAGTTTATTTTCCTATTAAATATCAATATTATAACACAAGAGAAAGAAGTGTGAACAAACAAGCAACAGTTTA
TGACCAGCGTATATATAGCAATGGAAAGTTGCATCTTTGCTGTGAAAACACTTTAAAGAAAATACTTTTTAAAAAATCCCACAGCTTTTTGGTTGCCACT
AGACGCTTCTTATTTTAATCATTTTAGTAATGCTCAGCTGGACCAGTGTTAGTTATATTTGAGTCAGAAAAATGTTGTTTTTCAACTTGCTTTATAATCT
CCTGCATCTATCTCCTGCTGTAGCATCACGAAGGTGTCAGGCAACAGTGAAAAGTGCACATTTTTGTTGTTGCAGAAACTGTGTCAGAGGAATAAGTAAA
TCAGCCTGCAGCAGAAGACTTTGTTCAGCTCCAGAGGCATCTGTGACCGTCTGTGTCCAAGTCTCTCTGTGCCTTTTTCTTTTACAAACTGAAGCTGTGG
AGCCAATGAAGTAACAGTAGAGATTGTAGGGAAAGAATACCTCAGGAAAAACAAATACACTTACAAGAAGACCCTGTTCTTAGAAAATGTGTTTAGTTAT
GGGTTAGCACTAGAAGAGACTTGGCTGTCAGCCAGCCAAGTGAAGGACCTCTCATCCATTCCCATTCATGTCCCATCATAATACGGACCCAAAAAGCAAA
CTCGGTTTTGCCATCAGTTAGAAATTACGTTTTGGATTGTATATTGTTACATCTCTCTTCCGGCTTAGTTTTTAGTGTCTGATTGTGACCTCTGCATTTA
TCTTCAAATACCCTAATTTTAAAACAAAAGAACAAGAAAAGTTTATAACACCATGTTCACTAAAACCACGGTTGAATCTTGGGTGTGGGCATCCTTTCGA
GTGTTGTCCATAAGAGCAGTTCGTGGAATTTTGCCCATCTGACCCATATTATCAGCTTATTCTGCCACCAGAGTAGAGTCTAATAAATTCCAAAGTTTTT
ATTTGCTCCATGGTGTATGTTCTGACTTTGAAAATGTCAGATTCTATAATCATACCCCTAACATCCAGGAAACAAATGACAGATTATCTTTAAACTGAAA
TTGACTCTACAATGCAACCCTTAATGCTGAATGGATTAAAAAAGTCAGCCCTTTTAGTATCTGTTTGAAAGGGCCGTAAAAAGTTGACACTTTTGTTGTT
GTGGATCCTGCGTGTCTAGACCCACGTGTTGTTTCCATCGTATACTGTAGGGTGCACCCCTTGGGATTCATCATTAAGAACTGAGGCTCACTGTTGTCAG
AAACAAAGCTCCCACCCCCCAGGTTCAACCTTGTGGGAGAACTGTTGAGCATGAGAATGTTCTAGACTCAGAGGTACTAAAATTTGTTACCACATCATTG
CTTCCTTTCTACAGGACGAATTGAGGCTTAAACTTTACTGTTAATGATACTGGTTCATTTTAATGTGCTTGTTGGTATGTTGCTATTTTTCATTTCATAG
CTTTCAAAAATCATGCTAATTGTATACTTGTCTAGTTTAAGGCTATTTTAAAATATGTACAATACTATTCACAGCATTTAGTTCGTTTAATTTTTATTAT
AAAGCAATCTACTAAAAAAGTACAACTGTATTTGAACTTTTCAATAGTTGTTTGTGAGCTATGATAATCAAAAGTCATTAAAGTCTTTTTTAACAAACAT
TCGTGCTTACTTTTCAACATAATTCCCAGTTATATACAGAAAAAGATTTCCACCTGTCACGTATCTGCCTCTTTTACCTGAGCAATGGTGTAGTTCTTAG
ACCTAAGGTCTGTAATTGCAATACTTTTAAAGAAAGATGTTGCTCTAAGTGCTGTTTGTTAGTTATGAAATCAGATTTTTCTGCTTGTTCTTAATGCTGT
GGTCAAACCATAGCACAAAATCATTAAAAATAATCAGCGGCATAC
- refseq_C18orf1.F1 (forward primer)
- refseq_C18orf1.R1 (reverse primer)
- Single exon skipping
Frame 0
GTLSILTLKESLWCFCATIHGE**CEAEGEGMNGRAKREERAGGKGARSVSCCG*DLTPCQYRARWQ
EPLGAAPIS*RMWRGSTRRGQPAAWLAA*GTLW
VLPAGRARSGSGSAGEKHASLT*ASRLSRVLPW
*APSPVLPH*KLPAEIKGRSIV*DLQISSFLSGL
V*YLPVEKITERSVTR*AV*LRSACLCV*HVQV
*GQT*EVQTAH**TLL*TVVPWVYSWSQDRRPR
TYSLLGDTAGFLPQSSWFLLMAVDNW*PQSAVGA
TAFESSTWGGPC*YSRERVNEADRNTPPPPPRS
HTLPHPMPAITAALSCLERRLPEAEGML*TWGG
CVTVGLPLAEDLIMSSDHLNNSTLKEAQFKDLFL
KKAELEFAQIIIIVVVVTVMVVVIVCLLNHYKV
STRSFINRPNQSRRREDGLPQEGCLWPSDSAAP
RLGASEIMHAPRSRDRFTAPSFIQRDRFSRFQPT
YPYVQHEIDLPPTISLSDGEEPPPYQGPCTLQL
RDPEQQMELNRESVRAPPNRTIFDSDLIDIAMY
SGGPCPPSSNSGISASTCSSNGRMEGPPPTYSEV
MGHHPGASFLHHQRSNAHRGSRLQFQQNNAEST
IVPIKGKDRKPGNLV*FLPTCTSAGERNQEGKR
PLGPSCAQCCSVSHGTNK*NQMSKHGLCF*FLLG
ELHAN*TEMIQTSIWSDRKQCLFGDRGWDGGVG
RGKQRTGCFEDTMK*NPQRYLMYLIVKGDFADK
*GQNGMFYN*LNKEGSIIIYYCGEEPASSLFLLR
CGTFILF*KYESKFLCCVPRYKVEKLDECKELL
CVVMMCFKSCTILMLKIFTRELFYVKFCMLSFH
LWIVIRPKEYPGVVPRSIQEKIFGDVA*HFTNLR
KSKKSLLLQEFASNSSASLKLLETFGWKIR*GR
LSSSISDLLF*VTLLLLGCIVYEKMNTCIYGSS
IMQCCPHPPAVQFLQ*FRFFSL*HEIYSNTYLIL
CNKLFKMQGGYSAYC*NM*LLSIFPLPLPLSST
A*FSSAGLLSSQEAPSSHPTSSLHRTSCGSGVG
GGFLCFGSP*K**RKNAMLLIVVISHCGLLYVTS
ISIAFLKECSAQNLPKFPQDSTKPFPRPAFVLK
ARTGQSENSGGGK*LKSTG*KAQHAVKMQLEN*
F*ILLVLIFLIFTNIHSYIQ*KK*LSSADVSTGF
YKSSSQHV*QTLRVEKGLSAVHSAMWRVGLCGL
FT*QDELE**FHDSHLCSLKAKSACVCLCLSVG
LEGDPSVRWLCAVTGETVPNPKSCLILVCSLLLL
TSVDRSLVFVCLF*GLEFPLHSSFAHSNIHRTS
PTLKRREEKHRHQLSAHAYNLCGSIYS*ESQWR
F*DWIQSCSSDSWKASAGETPALRAEIGLGPEGP
SPTLETP*RFTGSPD*PLFLCQAKMRSPCSHRA
LLAGTCSGFLVRCAHRCGGEVSDSIISVLTCSF
GEAGDAPHSSSSQMASQSLLLYLPQEGAQSRDL*
IP**L*VYECVAHVHSIGEIIT*FRYL*SSFKK
EAPPIQPP*RTAFVK*LFKDSYISNHDFERSSR
LGLCNELV*KPRS*HELMVNFPSAEGKGDLDQ*L
F*RLWLTCSYRVASWLVWR*KSSDWEDTTYTVG
PIVLSRTLFLAYRTHGSSLVTSDLGNQ**VYNL
RLFQQSVDCIVRKNIWWE*TLLGIPLTFVPCSRC
RRPKAS*IPSIRTQSSSIRLLFQKL*HSL*ILT
QSLMEKRFHEANYVFQ*FFYF*CPKFTNTEA*Q
ACPHPPHHINTWTHTQATRNPKRAEANF*KIYRE
DCISIH*FWLKLMRQEIGANSKWGRPPDTSRGI
LYPGEDFLNFCVSPFDLFHLYFIFIRMRKAQKE
ALLEIFSDLEESIQIPAFLSEPTVPFSDRGHPLS
SIQRLFFLGRLWCRALQICPQARY*LLVERHPA
PSPKPSLKGPAHGVGHWQAQRHSAVGAGSPAPH
AAMTGCAPISGACCTACLLNFAT*NGNINFVYHS
FFKNFPKLGSV*KKKLGKILGFC*LLCCLLK*L
KPVLGAKPSCHEHAPQPALCSPAHTDQECRVLG
LLR*KDN*MTGGQRENFPFLVRGKSQI*KCCFQP
RS*MLVLSSCVAYRSPFPPPPAASTATDHRDVN
RQWKALLALQWSTFFRNQYFSILYYPARCVLCR
VQVYVTARVRQSFAAAAAAAASRTGCIRKLLSEC
RNVLLRKQCLPSSFSFFPLRVLVFV*CGRGLEL
*RLYIHYPCTLYICRYTPIMSEICMSVFQQLRC
LMF*VQQI*EPSRPLLHLMLPPLLCLT*NGAFFS
CLSFLMFLFVRCCI*VEYIMHISYPMGRTKSC*
YCNIMYR*YQF*QKWHRICECLCALSSFVRKFA
NGCIQIKVYVVYFPIKYQYYNTRERSVNKQATVY
DQRIYSNGKLHLCCENTLKKILFKKSHSFLVAT
RRFLF*SF**CSAGPVLVIFESEKCCFSTCFII
SCIYLLL*HHEGVRQQ*KVHIFVVAETVSEE*VN
QPAAEDFVQLQRHL*PSVSKSLCAFFFYKLKLW
SQ*SNSRDCRERIPQEKQIHLQEDPVLRKCV*L
WVSTRRDLAVSQPSEGPLIHSHSCPIIIRTQKAN
SVLPSVRNYVLDCILLHLSSGLVFSV*L*PLHL
SSNTLILKQKNKKSL*HHVH*NHG*ILGVGILS
SVVHKSSSWNFAHLTHIISLFCHQSRV**IPKFL
FAPWCMF*L*KCQIL*SYP*HPGNK*QIIFKLK
LTLQCNP*C*MD*KSQPF*YLFERAVKS*HFCC
CGSCVSRPTCCFHRIL*GAPLGIHH*ELRLTVVR
NKAPTPQVQPCGRTVEHENVLDSEVLKFVTTSL
LPFYRTN*GLNFTVNDTGSF*CACWYVAIFHFI
AFKNHANCILV*FKAILKYVQYYSQHLVRLIFII
KQSTKKVQLYLNFSIVVCEL**SKVIKVFFNKH
SCLLFNIIPSYIQKKISTCHVSASFT*AMV*FL
DLRSVIAILLKKDVALSAVC*L*NQIFLLVLNAV
VKP*HKIIKNNQRH
Frame 1
EH*AS*L*RSLCGVFVLPYMGNNDVRQRERE*MGEPRGKSEPGGKERAVFPAAVRTSRLASTELGG
KSRWELLPSVRGCGEGAPEEDSPQPGSQPEGRCG
CSQPGEHALGADLQGRSTRA*RERPACRVSCLG
KRPLRSFHTESFQQRSREGVLCETCRFPPFCLD
WFDICLLKRLLNAV*QDEPSSCVLLACVCDTSRC
EAKPEKCRLLTDRRCCKQ*CPGCTAGLRIGDPG
LILCSVTRPASCRRAPGFC*WQLIIGSHSLRSE
PQHLSLAPGVGPADTVERE*TRQTETHPPPLHAH
TLSHTPCQL*LQL*AAWRGDCRKLKGCFERGGA
ASQLDSHLQRT*LCPVTT*TTAH*RRLSSKTCS
*KKRSWSSPKSSSSSWWSR*WWWSSSAC*TTTKS
PRGPSSTARTRAGGGRTGCRRKGACGLQTAPHR
GWAPRRSCMPRGPGTGSQRRPSSRGIASAASSP
PTPMCSTRLIFLPPSPCPTVKSHLLTRGPAPCSS
GTLNSRWNSTESP*GPHPTEPYLTVI**TLLCI
AGVHAHPAATRASVQAPAAVTGGWRGHPPHTAR
*WATTQAPLSSITSAATHTGAADCSFSRTMQRAQ
*YPSKAKIGSLGTWSDSFQRALQLEKETKKGSG
RWAPPAHSVVQFHMVQISKTK*ANTVFVSDSF*
GNCMQTRLK*YKLPSGLTANSVYLGTGVGMGVWA
GENRERDALKIP*NKTHRGI*CI*L*KETLQIN
EARMACFIIN*IKKEALLYIIVGKNQPVRFFS*
GVELLFCFKNMNQNSCVVCQGIKWRS*MSARSSF
VL**CVLKVALS*C*KYLQGNCFT*SSVCCLFT
CGL*SGPRNILEWSPEASKKRYLGT*PNILPTY
VNQKSHYCCRSLHQIAVHR*SFWRLLDGR*DRED
*VPAFLTCYFELLCYS*AA*FMRK*THAFMDPV
SCSAALILQQCNFFSNLDFFHYSMKYIQIHTLF
YAINCLKCKVVILHTVEICDSSVYSHCLSPFPRQ
LSSVLQGCSVHRRLPAATPHPAYTELRVGVVWV
VVSYALEAPRNNDGRMPCC*SW**AIVGYCMSL
VLA*HS*RNAVLKTYPNSRRILPNPSPGQLLY*R
QELDSQRTVEGASD*RAPGKKHNMQLKCN*KTN
FKYC*F*YS*YLQIFILIYNEKNNFLLQM*ALA
FIRAAANTFSRHCAWRRAYLQYTLPCGGWASVAS
SHNKMSWNDDSMTPTYAALKPNPRVCVCVCLWV
SKVIRRCGGSVL*LERLFQTPRVV*S*SVPFCF
LPL*IGHWFLFVCFEDWNFHYIHPLHTVTSTELV
QLLKGERKNTGTSCQLMLTTCVEVYTVESHSGG
SETGFSLVPVTVGRPLLERHQLSGQRLAWGQKD
PPQPWRHPEGSLALQISLSSSVRQR*GARVPIGP
CWQGLAVDSWSGVPTDAEAR*VIPSFQFSPAVL
VKQEMHPTALALKWLHSPYFSTCLKKGLRAETC
EFLSNCEYMNVLHMSTVLAR*LHNSDTFNHLSRK
RLLPFNHPRELPLLNSYLKTHTYQTMTLKGLRG
WGSVMN*FKSQGHNMN*WSISLQQKEKVI*ISS
SFEGCG*PVHTVSPHG*CGVERVATGKIQLTQWG
LLFFQEPFF*LIEPMGPV**RVI*AINDRFIIL
DYSSKVWIALLGRTFGGNEHSWAYR*LLSLVPG
VGDPRHLESHL*EHNLPAYVCFFRNSSILFKY*R
NP*WKRDFMKQIMYFNSSSIFSVQNLLIQKLDK
HVLTLPTT*THGHTPKPQEIPREQKRIFKRFIV
RTAFPFTNFGSNL*GRK*GPTVNGGGLLTPAEEF
CTQARTS*TSAYLRLISFTFISSS*E*ERLKRK
HF*KSSLT*KNPSKSLPSSLNQQFPSLTGAILY
LPSSGSSF*EGSGAEHFKYVLRPDTDC**RDTRH
PVRSPPSKDRLMALVTGRLRDILLWAQGARPPM
QP*LDAPPSRGLAALLVY*ILLLRMATLTLCTI
HFLKIFQSSAVYERKNWERYLVSVNFCVACLSD*
SQCLEPSLHATNMLHSLPFALLLTLTKNAACLA
Y*GERTIE*QVGKGRTSPSWCEESHKFKNVASS
PDPKC*FSAAAWLTVRHFHHRQLPAPLQITEM*T
DNGKHS*PCSGLHFLGTNISAFFITRHAVSFAE
FKFMLLPGSDSHLLLLLLLLLLELDALGSCCLS
VGMSC*ESNVFLHPFLSSLCVSLFLCNAGEG*SY
RDYIYTIRAHYIYVDIPLSCQRSACQFFSN*GA
SCSEFSRYRNQAAPSCT*CSHLCCASLKMVLFS
VVCLFLCFYL*GAVYKLNILCTYPTQWVEQKVVN
TVI*CIDDTNFNRNGIEFVNAYVLCPLL*GNLQ
MDAYRLKSM*FIFLLNINIITQEKEV*TNKQQF
MTSVYIAMESCIFAVKTL*RKYFLKNPTAFWLPL
DASYFNHFSNAQLDQC*LYLSQKNVVFQLAL*S
PASISCCSITKVSGNSEKCTFLLLQKLCQRNK*
ISLQQKTLFSSRGICDRLCPSLSVPFSFTN*SCG
ANEVTVEIVGKEYLRKNKYTYKKTLFLENVFSY
GLALEETWLSASQVKDLSSIPIHVPS*YGPKKQ
TRFCHQLEITFWIVYCYISLPA*FLVSDCDLCIY
LQIP*F*NKRTRKVYNTMFTKTTVESWVWASFR
VLSIRAVRGILPI*PILSAYSATRVESNKFQSF
YLLHGVCSDFENVRFYNHTPNIQETNDRLSLN*N
*LYNATLNAEWIKKVSPFSICLKGP*KVDTFVV
VDPACLDPRVVSIVYCRVHPLGFIIKN*GSLLS
ETKLPPPRFNLVGELLSMRMF*TQRY*NLLPHHC
FLSTGRIEA*TLLLMILVHFNVLVGMLLFFIS*
LSKIMLIVYLSSLRLF*NMYNTIHSI*FV*FLL
*SNLLKKYNCI*TFQ*LFVSYDNQKSLKSFLTNI
RAYFST*FPVIYRKRFPPVTYLPLLPEQWCSS*
T*GL*LQYF*RKMLL*VLFVSYEIRFFCLFLML
WSNHSTKSLKIISGI
Frame 2
NIEHPDFEGVSVVFLCYHTWGIMM*GRGRGNEWESQEGRASRGERSAQCFLLRLGPHALPVQSSVA
RAAGSCSHQLEDVEREHQKRTARSLARSLRDAV
GAPSRASTLWERICRGEAREPNVSVPPVACPALV
SALSGPSTLKASSRDQGKEYCVRLADFLLSVWT
GLIFAC*KDY*TQCDKMSRLAAFCLPVCVTRPG
VRPNLRSADCSLIDVAVNSSALGVQLVSGSETPD
LFSAR*HGRLPAAELLVSVDGS**LVATVCGRS
HSI*V*HLGWALLIQ*RESERGRQKHTPPPSTL
THSPTPHASYNCSSELPGEEIAGS*RDALNVGGL
RHSWTPTCRGPDYVQ*PPEQQHTEGGSVQRPVL
KKSGAGVRPNHHHRRGGHGDGGGHRLPAEPLQS
LHAVLHQPPEPEPEAGGRAAAGRVPVAFRQRRTA
AGRLGDHACPAVQGQVHSAVLHPEGSLQPLPAH
LPLCAARD*SSSHHLPVRR*RATSLPGALHPAA
PGP*TADGTQPRVREGPTQPNHI*Q*FNRHCYV*
RGSMPTQQQLGHQCKHLQQ*REDGGATPHIQRG
DGPPPRRLFPPSPAQQRTQGQQTAVSAEQCREH
NSTHQRQR*EAWEPGLIPSNVHFSWRKKPRREAA
AGPLLRTVLFSFTWYK*VKPNEQTRSLFLIPFR
GIACKLD*NDTNFHLV*PQTVFIWGQGLGWGCG
QGKTENGML*RYHEIKPTEVFDVFNCERRLCR*M
RPEWHVL*LTE*RRKHYYILLWGRTSQFAFSPK
VWNFYFVLKI*IKIPVLCAKV*SGEVR*VQGAP
LCCDDVF*KLHYLNVENIYKGTVLREVLYVVFSP
VDCNQAQGISWSGPQKHPRKDIWGRSLTFYQLT
*IKKVIIVAGVCIK*QCIAEAFGDFWMEDKIGK
IKFQHF*LVILSYSATLRLHSL*ENEHMHLWIQY
HAVLPSSSSSAISSVI*IFFTIA*NIFKYIPYF
MQ*IV*NARWLFCILLKYVTPQYIPIASPPFLD
SLVQFCRAAQFTGGSQQPPHIQPTQNFVWEWCGW
WFLMLWKPLEIMTEECHVADRGNKPLWVIVCH*
Y*HSILKGMQCSKPTQIPAGFYQTLPQASFCTE
GKNWTVREQWRGQVTEEHRVKSTTCS*NATRKLI
LNIVSFNIPDIYKYSFLYTMKKITFFCRCKHWL
L*EQQPTRLADTARGEGLICSTLCHVEGGPLWP
LHITR*AGMMIP*LPPMQP*SQIRVCVFVSVCGS
RR*SVGAVALCCNWRDCSKPQELSDPSLFPSAS
YLCR*VTGFCLFVLRIGISITFILCTQ*HPQN*
SNS*KERGKTQAPVVSSCLQPVWKYIQLRVTVEV
LRLDSVLFQ*QLEGLCWRDTSSQGRDWLGARRT
LPNPGDTLKVHWLSRLASLPLSGKDEEPVFPSG
PAGRDLQWILGQVCPQMRRRGE*FHHFSSHLQFW
*SRRCTPQL*LSNGFTVLTSLPASRRGSEQRLV
NSLVTVSI*MCCTCPQYWRDNYIIQIPLIIFQE
RGSSHSTTLENCLC*IVI*RLIHIKP*L*KVFEA
GAL**ISLKAKVIT*IDGQFPFSRRKR*FRSVA
LLKVVADLFIPCRLMASVALKE*RLGRYNLHSG
AYCSFKNPFFSL*NPWVQFSNE*FRQSMIGL*S*
IIPAKCGLHC*EEHLVGMNTPGHTADFCPLFPV
*ETQGILNPIYKNTIFQHTFAFSETLAFSLNTD
AILNGKEIS*SKLCISIVLLFLVSKIY*YRSLTS
MSSPSPPHKHMDTHPSHKKSQESRSEFLKDLS*
GLHFHSLILAQTYEAGNRGQQ*MGEAS*HQQRN
FVPRRGLLELLRISV*SLSPLFHLHKNEKGSKGS
TFRNLL*PRRIHPNPCLPL*TNSSLL*QGPSSI
FHPAALLFRKALVQSTSNMSSGQILIASRETPG
TQSEALPQRTGSWRWSLAGSETFCCGRREPGPPC
SHDWMRPHLGGLLHCLFIEFCYLEWQH*LCVPF
IF*KFSKARQCMKEKTGKDTWFLLTFVLLA*VI
KASAWSQAFMPRTCSTACPLLSCSH*PRMPRAWP
TEVKGQLNDRWAKGELPLLGARKVTNLKMLLPA
QILNASSQQLRGLPFAISTTASCQHRYRSQRCE
QTMESTLSLAVVYIF*EPIFQHSLLPGTLCPLQS
SSLCYCQGQTVICCCCCCCCFSNWMH*EAAV*V
*ECLAKKAMSSFILFFLPSACPCFCVMRERVRA
IEIIYTLSVHIIYM*IYPYHVRDLHVSFSATKVP
HVLSSADIGTKPPPPALDAPTFVVPHLKWCFFQ
LSVFSYVFICKVLYIS*IYYAHILPNG*NKKLL
IL*YNV*MIPILTEMA*NL*MPMCFVLFCKEICK
WMHTD*SLCSLFSY*ISIL*HKRKKCEQTSNSL
*PAYI*QWKVASLL*KHFKENTF*KIPQLFGCH
*TLLILIILVMLSWTSVSYI*VRKMLFFNLLYNL
LHLSPAVASRRCQATVKSAHFCCCRNCVRGISK
SACSRRLCSAPEASVTVCVQVSLCLFLLQTEAV
EPMK*Q*RL*GKNTSGKTNTLTRRPCS*KMCLVM
G*H*KRLGCQPAK*RTSHPFPFMSHHNTDPKSK
LGFAIS*KLRFGLYIVTSLFRLSF*CLIVTSAF
IFKYPNFKTKEQEKFITPCSLKPRLNLGCGHPFE
CCP*EQFVEFCPSDPYYQLILPPE*SLINSKVF
ICSMVYVLTLKMSDSIIIPLTSRKQMTDYL*TE
IDSTMQPLMLNGLKKSALLVSV*KGRKKLTLLLL
WILRV*THVLFPSYTVGCTPWDSSLRTEAHCCQ
KQSSHPPGSTLWENC*A*ECSRLRGTKICYHII
ASFLQDELRLKLYC**YWFILMCLLVCCYFSFHS
FQKSC*LYTCLV*GYFKICTILFTAFSSFNFYY
KAIY*KSTTVFELFNSCL*AMIIKSH*SLF*QT
FVLTFQHNSQLYTEKDFHLSRICLFYLSNGVVLR
PKVCNCNTFKERCCSKCCLLVMKSDFSACS*CC
GQTIAQNH*K*SAAY
Sequence NM_181481
CCGAGCCCCGGAGGAAGCAGGCGTGTGTTGAATTTCTCTCTGCCCCTCACCTTGGAATAAACAGGAAGCGACAAGCACCCAGCCCGGCCCGGCACTTGCCTTTGTGAAGGGGTCTGCCCTGCACAGCCTTTAGGAAGCTTCCTCGGGACCCCTTCCCGGTGCGCCGCCCCGGGTGGGCCTGGGGGCGCGCCCTCGGTTCA
AGCTCTACGTTCGTGACATCAAACCTCCTGTTGGGCCATTTCCGAGAACTCCCATCAGTTTCTGTATAGTGTAAAAGTTTCAGAGGCGGAGCACAGAGAG
CTGCGGCTGGGACAAGGAGCACCCGCGTGCAGGTGCGACCCTGCAGGATGCTGGCAGCGGCGTGGCCAGGGGCGCCCGTGTTCTGAGGGCCTGAGGGCCA
GCCCCTCCACCCGCGCCATGGCCTCCGCGCCCTGGCTGGACGGCTGACGGGAGCAGGGACCGCCGCCGCCCAGGTGCCACACCCAGGTACCGCCCGCCCG
CGCGAGAGCCGGGCAGGTGGGCCGCGGATGCTCCCAGAGGCCGGCCCAGCAGAGCGATGGACTTGGACAGGCTAAGATGGAAGTGACCTGAGCCTCGCCC
GGCGGCTTCCTCGACGGGACAGCGCAAGAGTTGGAGCACAGGCTTGTCCGGGGAGCAGTATGCCGGAAGCTGGTTTTCAGGCCACAAATGCTTTCACAGA
GTGCAAATTCACCTGCACCAGTGGTAAATGCTTGTATCTTGGTTCGCTGGTCTGTAACCAACAGAACGACTGTGGGGACAACAGTGACGAAGAGAACTGT
CTCCTGGTGACCGAGCACCCGCCTCCGGGCATCTTCAACTCGGAGCTGGAGTTCGCCCAAATCATCATCATCGTCGTGGTGGTCACGGTGATGGTGGTGG
TCATCGTCTGCCTGCTGAACCACTACAAAGTCTCCACGCGGTCCTTCATCAACCGCCCGAACCAGAGCCGGAGGCGGGAGGACGGGCTGCCGCAGGAAGG
GTGCCTGTGGCCTTCAGACAGCGCCGCACCGCGGCTGGGCGCCTCGGAGATCATGCATGCCCCGCGGTCCAGGGACAGGTTCACAGCGCCGTCCTTCATC
CAGAGGGATCGCTTCAGCCGCTTCCAGCCCACCTACCCCTATGTGCAGCACGAGATTGATCTTCCTCCCACCATCTCCCTGTCCGACGGTGAAGAGCCAC
CTCCTTACCAGGGGCCCTGCACCCTGCAGCTCCGGGACCCTGAACAGCAGATGGAACTCAACCGAGAGTCCGTGAGGGCCCCACCCAACCGAACCATATT
TGACAGTGATTTAATAGACATTGCTATGTATAGCGGGGGTCCATGCCCACCCAGCAGCAACTCGGGCATCAGTGCAAGCACCTGCAGCAGTAACGGGAGG
ATGGAGGGGCCACCCCCCACATACAGCGAGGTGATGGGCCACCACCCAGGCGCCTCTTTCCTCCATCACCAGCGCAGCAACGCACACAGGGGCAGCAGAC
TGCAGTTTCAGCAGAACAATGCAGAGAGCACAATAGTACCCATCAAAGGCAAAGATAGGAAGCCTGGGAACCTGGTCTGATTCCTTCCAACGTGCACTTC
AGCTGGAGAAAGAAACCAAGAAGGGAAGCGGCCGCTGGGCCCCTCCTGCGCACAGTGTTGTTCAGTTTCACATGGTACAAATAAGTAAAACCAAATGAGC
AAACACGGTCTTTGTTTCTGATTCCTTTTAGGGGAATTGCATGCAAACTAGACTGAAATGATACAAACTTCCATCTGGTCTGACCGCAAACAGTGTTTAT
TTGGGGACAGGGGTTGGGATGGGGGTGTGGGCAGGGGAAAACAGAGAACGGGATGCTTTGAAGATACCATGAAATAAAACCCACAGAGGTATTTGATGTA
TTTAATTGTGAAAGGAGACTTTGCAGATAAATGAGGCCAGAATGGCATGTTTTATAATTAACTGAATAAAGAAGGAAGCATTATTATATATTATTGTGGG
GAAGAACCAGCCAGTTCGCTTTTTCTCCTAAGGTGTGGAACTTTTATTTTGTTTTAAAAATATGAATCAAAATTCCTGTGTTGTGTGCCAAGGTATAAAG
TGGAGAAGTTAGATGAGTGCAAGGAGCTCCTTTGTGTTGTGATGATGTGTTTTAAAAGTTGCACTATCTTAATGTTGAAAATATTTACAAGGGAACTGTT
TTACGTGAAGTTCTGTATGTTGTCTTTTCACCTGTGGATTGTAATCAGGCCCAAGGAATATCCTGGAGTGGTCCCCAGAAGCATCCAAGAAAAGATATTT
GGGGACGTAGCCTAACATTTTACCAACTTACGTAAATCAAAAAAGTCATTATTGTTGCAGGAGTTTGCATCAAATAGCAGTGCATCGCTGAAGCTTTTGG
AGACTTTTGGATGGAAGATAAGATAGGGAAGATTAAGTTCCAGCATTTCTGACTTGTTATTTTGAGTTACTCTGCTACTCTTAGGCTGCATAGTTTATGA
GAAAATGAACACATGCATTTATGGATCCAGTATCATGCAGTGCTGCCCTCATCCTCCAGCAGTGCAATTTCTTCAGTAATTTAGATTTTTTTCACTATAG
CATGAAATATATTCAAATACATACCTTATTTTATGCAATAAATTGTTTAAAATGCAAGGTGGTTATTCTGCATACTGTTGAAATATGTGACTCCTCAGTA
TATTCCCATTGCCTCTCCCCCTTTCCTCGACAGCTTAGTTCAGTTCTGCAGGGCTGCTCAGTTCACAGGAGGCTCCCAGCAGCCACCCCACATCCAGCCT
ACACAGAACTTCGTGTGGGAGTGGTGTGGGTGGTGGTTTCTTATGCTTTGGAAGCCCCTAGAAATAATGACGGAAGAATGCCATGTTGCTGATCGTGGTA
ATAAGCCATTGTGGGTTATTGTATGTCACTAGTATTAGCATAGCATTCTTAAAGGAATGCAGTGCTCAAAACCTACCCAAATTCCCGCAGGATTCTACCA
AACCCTTCCCCAGGCCAGCTTTTGTACTGAAGGCAAGAACTGGACAGTCAGAGAACAGTGGAGGGGGCAAGTGACTGAAGAGCACCGGGTAAAAAGCACA
ACATGCAGTTAAAATGCAACTAGAAAACTAATTTTAAATATTGTTAGTTTTAATATTCCTGATATTTACAAATATTCATTCTTATATACAATGAAAAAAA
TAACTTTCTTCTGCAGATGTAAGCACTGGCTTTTATAAGAGCAGCAGCCAACACGTTTAGCAGACACTGCGCGTGGAGAAGGGCTTATCTGCAGTACACT
CTGCCATGTGGAGGGTGGGCCTCTGTGGCCTCTTCACATAACAAGATGAGCTGGAATGATGATTCCATGACTCCCACCTATGCAGCCTTAAAGCCAAATC
CGCGTGTGTGTGTTTGTGTCTGTCTGTGGGTCTCGAAGGTGATCCGTCGGTGCGGTGGCTCTGTGCTGTAACTGGAGAGACTGTTCCAAACCCCAAGAGT
TGTCTGATCCTAGTCTGTTCCCTTCTGCTTCTTACCTCTGTAGATAGGTCACTGGTTTTTGTTTGTTTGTTTTGAGGATTGGAATTTCCATTACATTCAT
CCTTTGCACACAGTAACATCCACAGAACTAGTCCAACTCTTAAAAGGAGAGAGGAAAAACACAGGCACCAGTTGTCAGCTCATGCTTACAACCTGTGTGG
AAGTATATACAGTTGAGAGTCACAGTGGAGGTTCTGAGACTGGATTCAGTCTTGTTCCAGTGACAGTTGGAAGGCCTCTGCTGGAGAGACACCAGCTCTC
AGGGCAGAGATTGGCTTGGGGCCAGAAGGACCCTCCCCAACCCTGGAGACACCCTGAAGGTTCACTGGCTCTCCAGATTAGCCTCTCTTCCTCTGTCAGG
CAAAGATGAGGAGCCCGTGTTCCCATCGGGCCCTGCTGGCAGGGACTTGCAGTGGATTCTTGGTCAGGTGTGCCCACAGATGCGGAGGCGAGGTGAGTGA
TTCCATCATTTCAGTTCTCACCTGCAGTTTTGGTGAAGCAGGAGATGCACCCCACAGCTCTAGCTCTCAAATGGCTTCACAGTCCTTACTTCTCTACCTG
CCTCAAGAAGGGGCTCAGAGCAGAGACTTGTGAATTCCTTAGTAACTGTGAGTATATGAATGTGTTGCACATGTCCACAGTATTGGCGAGATAATTACAT
AATTCAGATACCTTTAATCATCTTTCAAGAAAGAGGCTCCTCCCATTCAACCACCCTAGAGAACTGCCTTTGTTAAATAGTTATTTAAAGACTCATACAT
ATCAAACCATGACTTTGAAAGGTCTTCGAGGCTGGGGCTCTGTAATGAATTAGTTTAAAAGCCAAGGTCATAACATGAATTGATGGTCAATTTCCCTTCA
GCAGAAGGAAAAGGTGATTTAGATCAGTAGCTCTTTTGAAGGTTGTGGCTGACCTGTTCATACCGTGTCGCCTCATGGCTAGTGTGGCGTTGAAAGAGTA
GCGACTGGGAAGATACAACTTACACAGTGGGGCCTATTGTTCTTTCAAGAACCCTTTTTTTAGCTTATAGAACCCATGGGTCCAGTTTAGTAACGAGTGA
TTTAGGCAATCAATGATAGGTTTATAATCTTAGATTATTCCAGCAAAGTGTGGATTGCATTGTTAGGAAGAACATTTGGTGGGAATGAACACTCCTGGGC
ATACCGCTGACTTTTGTCCCTTGTTCCCGGTGTAGGAGACCCAAGGCATCTTGAATCCCATCTATAAGAACACAATCTTCCAGCATACGTTTGCTTTTTC
AGAAACTCTAGCATTCTCTTTAAATACTGACGCAATCCTTAATGGAAAAGAGATTTCATGAAGCAAATTATGTATTTCAATAGTTCTTCTATTTTTAGTG
TCCAAAATTTACTAATACAGAAGCTTGACAAGCATGTCCTCACCCTCCCCACCACATAAACACATGGACACACACCCAAGCCACAAGAAATCCCAAGAGA
GCAGAAGCGAATTTTTAAAAGATTTATCGTGAGGACTGCATTTCCATTCACTAATTTTGGCTCAAACTTATGAGGCAGGAAATAGGGGCCAACAGTAAAT
GGGGGAGGCCTCCTGACACCAGCAGAGGAATTTTGTACCCAGGCGAGGACTTCTTGAACTTCTGCGTATCTCCGTTTGATCTCTTTCACCTTTATTTCAT
CTTCATAAGAATGAGAAAGGCTCAAAAGGAAGCACTTTTAGAAATCTTCTCTGACCTAGAAGAATCCATCCAAATCCCTGCCTTCCTCTCTGAACCAACA
GTTCCCTTCTCTGACAGGGGCCATCCTCTATCTTCCATCCAGCGGCTCTTCTTTTTAGGAAGGCTCTGGTGCAGAGCACTTCAAATATGTCCTCAGGCCA
GATACTGATTGCTAGTAGAGAGACACCCGGCACCCAGTCCGAAGCCCTCCCTCAAAGGACCGGCTCATGGCGTTGGTCACTGGCAGGCTCAGAGACATTC
TGCTGTGGGCGCAGGGAGCCCGGCCCCCCATGCAGCCATGACTGGATGCGCCCCCATCTCGGGGGCTTGCTGCACTGCTTGTTTATTGAATTTTGCTACT
TAGAATGGCAACATTAACTTTGTGTACCATTCATTTTTTAAAAATTTTCCAAAGCTCGGCAGTGTATGAAAGAAAAAACTGGGAAAGATACTTGGTTTCT
GTTAACTTTTGTGTTGCTTGCTTAAGTGATTAAAGCCAGTGCTTGGAGCCAAGCCTTCATGCCACGAACATGCTCCACAGCCTGCCCTTTGCTCTCCTGC
TCACACTGACCAAGAATGCCGCGTGCTTGGCCTACTGAGGTGAAAGGACAATTGAATGACAGGTGGGCAAAGGGAGAACTTCCCCTTCTTGGTGCGAGGA
AAGTCACAAATTTAAAAATGTTGCTTCCAGCCCAGATCCTAAATGCTAGTTCTCAGCAGCTGCGTGGCTTACCGTTCGCCATTTCCACCACCGCCAGCTG
CCAGCACCGCTACAGATCACAGAGATGTGAACAGACAATGGAAAGCACTCTTAGCCTTGCAGTGGTCTACATTTTTTAGGAACCAATATTTCAGCATTCT
TTATTACCCGGCACGCTGTGTCCTTTGCAGAGTTCAAGTTTATGTTACTGCCAGGGTCAGACAGTCATTTGCTGCTGCTGCTGCTGCTGCTGCTTCTCGA
ACTGGATGCATTAGGAAGCTGCTGTCTGAGTGTAGGAATGTCTTGCTAAGAAAGCAATGTCTTCCTTCATCCTTTTCTTTCTTCCCTCTGCGTGTCCTTG
TTTTTGTGTAATGCGGGAGAGGGTTAGAGCTATAGAGATTATATATACACTATCCGTGCACATTATATATATGTAGATATACCCCTATCATGTCAGAGAT
CTGCATGTCAGTTTTTCAGCAACTAAGGTGCCTCATGTTCTGAGTTCAGCAGATATAGGAACCAAGCCGCCCCCTCCTGCACTTGATGCTCCCACCTTTG
TTGTGCCTCACTTAAAATGGTGCTTTTTTCAGTTGTCTGTCTTTTCTTATGTTTTTATTTGTAAGGTGCTGTATATAAGTTGAATATATTATGCACATAT
CCTACCCAATGGGTAGAACAAAAAGTTGTTAATACTGTAATATAATGTATAGATGATACCAATTTTAACAGAAATGGCATAGAATTTGTGAATGCCTATG
TGCTTTGTCCTCTTTTGTAAGGAAATTTGCAAATGGATGCATACAGATTAAAGTCTATGTAGTTTATTTTCCTATTAAATATCAATATTATAACACAAGA
GAAAGAAGTGTGAACAAACAAGCAACAGTTTATGACCAGCGTATATATAGCAATGGAAAGTTGCATCTTTGCTGTGAAAACACTTTAAAGAAAATACTTT
TTAAAAAATCCCACAGCTTTTTGGTTGCCACTAGACGCTTCTTATTTTAATCATTTTAGTAATGCTCAGCTGGACCAGTGTTAGTTATATTTGAGTCAGA
AAAATGTTGTTTTTCAACTTGCTTTATAATCTCCTGCATCTATCTCCTGCTGTAGCATCACGAAGGTGTCAGGCAACAGTGAAAAGTGCACATTTTTGTT
GTTGCAGAAACTGTGTCAGAGGAATAAGTAAATCAGCCTGCAGCAGAAGACTTTGTTCAGCTCCAGAGGCATCTGTGACCGTCTGTGTCCAAGTCTCTCT
GTGCCTTTTTCTTTTACAAACTGAAGCTGTGGAGCCAATGAAGTAACAGTAGAGATTGTAGGGAAAGAATACCTCAGGAAAAACAAATACACTTACAAGA
AGACCCTGTTCTTAGAAAATGTGTTTAGTTATGGGTTAGCACTAGAAGAGACTTGGCTGTCAGCCAGCCAAGTGAAGGACCTCTCATCCATTCCCATTCA
TGTCCCATCATAATACGGACCCAAAAAGCAAACTCGGTTTTGCCATCAGTTAGAAATTACGTTTTGGATTGTATATTGTTACATCTCTCTTCCGGCTTAG
TTTTTAGTGTCTGATTGTGACCTCTGCATTTATCTTCAAATACCCTAATTTTAAAACAAAAGAACAAGAAAAGTTTATAACACCATGTTCACTAAAACCA
CGGTTGAATCTTGGGTGTGGGCATCCTTTCGAGTGTTGTCCATAAGAGCAGTTCGTGGAATTTTGCCCATCTGACCCATATTATCAGCTTATTCTGCCAC
CAGAGTAGAGTCTAATAAATTCCAAAGTTTTTATTTGCTCCATGGTGTATGTTCTGACTTTGAAAATGTCAGATTCTATAATCATACCCCTAACATCCAG
GAAACAAATGACAGATTATCTTTAAACTGAAATTGACTCTACAATGCAACCCTTAATGCTGAATGGATTAAAAAAGTCAGCCCTTTTAGTATCTGTTTGA
AAGGGCCGTAAAAAGTTGACACTTTTGTTGTTGTGGATCCTGCGTGTCTAGACCCACGTGTTGTTTCCATCGTATACTGTAGGGTGCACCCCTTGGGATT
CATCATTAAGAACTGAGGCTCACTGTTGTCAGAAACAAAGCTCCCACCCCCCAGGTTCAACCTTGTGGGAGAACTGTTGAGCATGAGAATGTTCTAGACT
CAGAGGTACTAAAATTTGTTACCACATCATTGCTTCCTTTCTACAGGACGAATTGAGGCTTAAACTTTACTGTTAATGATACTGGTTCATTTTAATGTGC
TTGTTGGTATGTTGCTATTTTTCATTTCATAGCTTTCAAAAATCATGCTAATTGTATACTTGTCTAGTTTAAGGCTATTTTAAAATATGTACAATACTAT
TCACAGCATTTAGTTCGTTTAATTTTTATTATAAAGCAATCTACTAAAAAAGTACAACTGTATTTGAACTTTTCAATAGTTGTTTGTGAGCTATGATAAT
CAAAAGTCATTAAAGTCTTTTTTAACAAACATTCGTGCTTACTTTTCAACATAATTCCCAGTTATATACAGAAAAAGATTTCCACCTGTCACGTATCTGC
CTCTTTTACCTGAGCAATGGTGTAGTTCTTAGACCTAAGGTCTGTAATTGCAATACTTTTAAAGAAAGATGTTGCTCTAAGTGCTGTTTGTTAGTTATGA
AATCAGATTTTTCTGCTTGTTCTTAATGCTGTGGTCAAACCATAGCACAAAATCATTAAAAATAATCAGCGGCATAC
- refseq_C18orf1.F1 (forward primer)
- refseq_C18orf1.R1 (reverse primer)
- Single exon skipping
Frame 0
PSPGGSRRVLNFSLPLTLE*TGSDKHPARPGTCLCEGVCPAQPLGSFLGTPSRCAAPGGPGGAPSVQ
ALRS*HQTSCWAISENSHQFLYSVKVSEAEHRE
LRLGQGAPACRCDPAGCWQRRGQGRPCSEGLRA
SPSTRAMASAPWLDG*REQGPPPPRCHTQVPPAR
ARAGQVGRGCSQRPAQQSDGLGQAKMEVT*ASP
GGFLDGTAQELEHRLVRGAVCRKLVFRPQMLSQ
SANSPAPVVNACILVRWSVTNRTTVGTTVTKRTV
SW*PSTRLRASSTRSWSSPKSSSSSWWSR*WWW
SSSAC*TTTKSPRGPSSTARTRAGGGRTGCRRK
GACGLQTAPHRGWAPRRSCMPRGPGTGSQRRPSS
RGIASAASSPPTPMCSTRLIFLPPSPCPTVKSH
LLTRGPAPCSSGTLNSRWNSTESP*GPHPTEPY
LTVI**TLLCIAGVHAHPAATRASVQAPAAVTGG
WRGHPPHTAR*WATTQAPLSSITSAATHTGAAD
CSFSRTMQRAQ*YPSKAKIGSLGTWSDSFQRAL
QLEKETKKGSGRWAPPAHSVVQFHMVQISKTK*A
NTVFVSDSF*GNCMQTRLK*YKLPSGLTANSVY
LGTGVGMGVWAGENRERDALKIP*NKTHRGI*C
I*L*KETLQINEARMACFIIN*IKKEALLYIIVG
KNQPVRFFS*GVELLFCFKNMNQNSCVVCQGIK
WRS*MSARSSFVL**CVLKVALS*C*KYLQGNC
FT*SSVCCLFTCGL*SGPRNILEWSPEASKKRYL
GT*PNILPTYVNQKSHYCCRSLHQIAVHR*SFW
RLLDGR*DRED*VPAFLTCYFELLCYS*AA*FM
RK*THAFMDPVSCSAALILQQCNFFSNLDFFHYS
MKYIQIHTLFYAINCLKCKVVILHTVEICDSSV
YSHCLSPFPRQLSSVLQGCSVHRRLPAATPHPA
YTELRVGVVWVVVSYALEAPRNNDGRMPCC*SW*
*AIVGYCMSLVLA*HS*RNAVLKTYPNSRRILP
NPSPGQLLY*RQELDSQRTVEGASD*RAPGKKH
NMQLKCN*KTNFKYC*F*YS*YLQIFILIYNEKN
NFLLQM*ALAFIRAAANTFSRHCAWRRAYLQYT
LPCGGWASVASSHNKMSWNDDSMTPTYAALKPN
PRVCVCVCLWVSKVIRRCGGSVL*LERLFQTPRV
V*S*SVPFCFLPL*IGHWFLFVCFEDWNFHYIH
PLHTVTSTELVQLLKGERKNTGTSCQLMLTTCV
EVYTVESHSGGSETGFSLVPVTVGRPLLERHQLS
GQRLAWGQKDPPQPWRHPEGSLALQISLSSSVR
QR*GARVPIGPCWQGLAVDSWSGVPTDAEAR*V
IPSFQFSPAVLVKQEMHPTALALKWLHSPYFSTC
LKKGLRAETCEFLSNCEYMNVLHMSTVLAR*LH
NSDTFNHLSRKRLLPFNHPRELPLLNSYLKTHT
YQTMTLKGLRGWGSVMN*FKSQGHNMN*WSISLQ
QKEKVI*ISSSFEGCG*PVHTVSPHG*CGVERV
ATGKIQLTQWGLLFFQEPFF*LIEPMGPV**RV
I*AINDRFIILDYSSKVWIALLGRTFGGNEHSWA
YR*LLSLVPGVGDPRHLESHL*EHNLPAYVCFF
RNSSILFKY*RNP*WKRDFMKQIMYFNSSSIFS
VQNLLIQKLDKHVLTLPTT*THGHTPKPQEIPRE
QKRIFKRFIVRTAFPFTNFGSNL*GRK*GPTVN
GGGLLTPAEEFCTQARTS*TSAYLRLISFTFIS
SS*E*ERLKRKHF*KSSLT*KNPSKSLPSSLNQQ
FPSLTGAILYLPSSGSSF*EGSGAEHFKYVLRP
DTDC**RDTRHPVRSPPSKDRLMALVTGRLRDI
LLWAQGARPPMQP*LDAPPSRGLAALLVY*ILLL
RMATLTLCTIHFLKIFQSSAVYERKNWERYLVS
VNFCVACLSD*SQCLEPSLHATNMLHSLPFALL
LTLTKNAACLAY*GERTIE*QVGKGRTSPSWCEE
SHKFKNVASSPDPKC*FSAAAWLTVRHFHHRQL
PAPLQITEM*TDNGKHS*PCSGLHFLGTNISAF
FITRHAVSFAEFKFMLLPGSDSHLLLLLLLLLLE
LDALGSCCLSVGMSC*ESNVFLHPFLSSLCVSL
FLCNAGEG*SYRDYIYTIRAHYIYVDIPLSCQR
SACQFFSN*GASCSEFSRYRNQAAPSCT*CSHLC
CASLKMVLFSVVCLFLCFYL*GAVYKLNILCTY
PTQWVEQKVVNTVI*CIDDTNFNRNGIEFVNAY
VLCPLL*GNLQMDAYRLKSM*FIFLLNINIITQE
KEV*TNKQQFMTSVYIAMESCIFAVKTL*RKYF
LKNPTAFWLPLDASYFNHFSNAQLDQC*LYLSQ
KNVVFQLAL*SPASISCCSITKVSGNSEKCTFLL
LQKLCQRNK*ISLQQKTLFSSRGICDRLCPSLS
VPFSFTN*SCGANEVTVEIVGKEYLRKNKYTYK
KTLFLENVFSYGLALEETWLSASQVKDLSSIPIH
VPS*YGPKKQTRFCHQLEITFWIVYCYISLPA*
FLVSDCDLCIYLQIP*F*NKRTRKVYNTMFTKT
TVESWVWASFRVLSIRAVRGILPI*PILSAYSAT
RVESNKFQSFYLLHGVCSDFENVRFYNHTPNIQ
ETNDRLSLN*N*LYNATLNAEWIKKVSPFSICL
KGP*KVDTFVVVDPACLDPRVVSIVYCRVHPLGF
IIKN*GSLLSETKLPPPRFNLVGELLSMRMF*T
QRY*NLLPHHCFLSTGRIEA*TLLLMILVHFNV
LVGMLLFFIS*LSKIMLIVYLSSLRLF*NMYNTI
HSI*FV*FLL*SNLLKKYNCI*TFQ*LFVSYDN
QKSLKSFLTNIRAYFST*FPVIYRKRFPPVTYL
PLLPEQWCSS*T*GL*LQYF*RKMLL*VLFVSYE
IRFFCLFLMLWSNHSTKSLKIISGI
Frame 1
RAPEEAGVC*ISLCPSPWNKQEATSTQPGPALAFVKGSALHSL*EASSGPLPGAPPRVGLGARPRF
KLYVRDIKPPVGPFPRTPISFCIV*KFQRRSTES
CGWDKEHPRAGATLQDAGSGVARGARVLRA*GP
APPPAPWPPRPGWTADGSRDRRRPGATPRYRPP
AREPGRWAADAPRGRPSRAMDLDRLRWK*PEPRP
AASSTGQRKSWSTGLSGEQYAGSWFSGHKCFHR
VQIHLHQW*MLVSWFAGL*PTERLWGQQ*RREL
SPGDRAPASGHLQLGAGVRPNHHHRRGGHGDGGG
HRLPAEPLQSLHAVLHQPPEPEPEAGGRAAAGR
VPVAFRQRRTAAGRLGDHACPAVQGQVHSAVLH
PEGSLQPLPAHLPLCAARD*SSSHHLPVRR*RAT
SLPGALHPAAPGP*TADGTQPRVREGPTQPNHI
*Q*FNRHCYV*RGSMPTQQQLGHQCKHLQQ*RE
DGGATPHIQRGDGPPPRRLFPPSPAQQRTQGQQT
AVSAEQCREHNSTHQRQR*EAWEPGLIPSNVHF
SWRKKPRREAAAGPLLRTVLFSFTWYK*VKPNE
QTRSLFLIPFRGIACKLD*NDTNFHLV*PQTVFI
WGQGLGWGCGQGKTENGML*RYHEIKPTEVFDV
FNCERRLCR*MRPEWHVL*LTE*RRKHYYILLW
GRTSQFAFSPKVWNFYFVLKI*IKIPVLCAKV*S
GEVR*VQGAPLCCDDVF*KLHYLNVENIYKGTV
LREVLYVVFSPVDCNQAQGISWSGPQKHPRKDI
WGRSLTFYQLT*IKKVIIVAGVCIK*QCIAEAFG
DFWMEDKIGKIKFQHF*LVILSYSATLRLHSL*
ENEHMHLWIQYHAVLPSSSSSAISSVI*IFFTI
A*NIFKYIPYFMQ*IV*NARWLFCILLKYVTPQY
IPIASPPFLDSLVQFCRAAQFTGGSQQPPHIQP
TQNFVWEWCGWWFLMLWKPLEIMTEECHVADRG
NKPLWVIVCH*Y*HSILKGMQCSKPTQIPAGFYQ
TLPQASFCTEGKNWTVREQWRGQVTEEHRVKST
TCS*NATRKLILNIVSFNIPDIYKYSFLYTMKK
ITFFCRCKHWLL*EQQPTRLADTARGEGLICSTL
CHVEGGPLWPLHITR*AGMMIP*LPPMQP*SQI
RVCVFVSVCGSRR*SVGAVALCCNWRDCSKPQE
LSDPSLFPSASYLCR*VTGFCLFVLRIGISITFI
LCTQ*HPQN*SNS*KERGKTQAPVVSSCLQPVW
KYIQLRVTVEVLRLDSVLFQ*QLEGLCWRDTSS
QGRDWLGARRTLPNPGDTLKVHWLSRLASLPLSG
KDEEPVFPSGPAGRDLQWILGQVCPQMRRRGE*
FHHFSSHLQFW*SRRCTPQL*LSNGFTVLTSLP
ASRRGSEQRLVNSLVTVSI*MCCTCPQYWRDNYI
IQIPLIIFQERGSSHSTTLENCLC*IVI*RLIH
IKP*L*KVFEAGAL**ISLKAKVIT*IDGQFPF
SRRKR*FRSVALLKVVADLFIPCRLMASVALKE*
RLGRYNLHSGAYCSFKNPFFSL*NPWVQFSNE*
FRQSMIGL*S*IIPAKCGLHC*EEHLVGMNTPG
HTADFCPLFPV*ETQGILNPIYKNTIFQHTFAFS
ETLAFSLNTDAILNGKEIS*SKLCISIVLLFLV
SKIY*YRSLTSMSSPSPPHKHMDTHPSHKKSQE
SRSEFLKDLS*GLHFHSLILAQTYEAGNRGQQ*M
GEAS*HQQRNFVPRRGLLELLRISV*SLSPLFH
LHKNEKGSKGSTFRNLL*PRRIHPNPCLPL*TN
SSLL*QGPSSIFHPAALLFRKALVQSTSNMSSGQ
ILIASRETPGTQSEALPQRTGSWRWSLAGSETF
CCGRREPGPPCSHDWMRPHLGGLLHCLFIEFCY
LEWQH*LCVPFIF*KFSKARQCMKEKTGKDTWFL
LTFVLLA*VIKASAWSQAFMPRTCSTACPLLSC
SH*PRMPRAWPTEVKGQLNDRWAKGELPLLGAR
KVTNLKMLLPAQILNASSQQLRGLPFAISTTASC
QHRYRSQRCEQTMESTLSLAVVYIF*EPIFQHS
LLPGTLCPLQSSSLCYCQGQTVICCCCCCCCFS
NWMH*EAAV*V*ECLAKKAMSSFILFFLPSACPC
FCVMRERVRAIEIIYTLSVHIIYM*IYPYHVRD
LHVSFSATKVPHVLSSADIGTKPPPPALDAPTF
VVPHLKWCFFQLSVFSYVFICKVLYIS*IYYAHI
LPNG*NKKLLIL*YNV*MIPILTEMA*NL*MPM
CFVLFCKEICKWMHTD*SLCSLFSY*ISIL*HK
RKKCEQTSNSL*PAYI*QWKVASLL*KHFKENTF
*KIPQLFGCH*TLLILIILVMLSWTSVSYI*VR
KMLFFNLLYNLLHLSPAVASRRCQATVKSAHFC
CCRNCVRGISKSACSRRLCSAPEASVTVCVQVSL
CLFLLQTEAVEPMK*Q*RL*GKNTSGKTNTLTR
RPCS*KMCLVMG*H*KRLGCQPAK*RTSHPFPF
MSHHNTDPKSKLGFAIS*KLRFGLYIVTSLFRLS
F*CLIVTSAFIFKYPNFKTKEQEKFITPCSLKP
RLNLGCGHPFECCP*EQFVEFCPSDPYYQLILP
PE*SLINSKVFICSMVYVLTLKMSDSIIIPLTSR
KQMTDYL*TEIDSTMQPLMLNGLKKSALLVSV*
KGRKKLTLLLLWILRV*THVLFPSYTVGCTPWD
SSLRTEAHCCQKQSSHPPGSTLWENC*A*ECSRL
RGTKICYHIIASFLQDELRLKLYC**YWFILMC
LLVCCYFSFHSFQKSC*LYTCLV*GYFKICTIL
FTAFSSFNFYYKAIY*KSTTVFELFNSCL*AMII
KSH*SLF*QTFVLTFQHNSQLYTEKDFHLSRIC
LFYLSNGVVLRPKVCNCNTFKERCCSKCCLLVM
KSDFSACS*CCGQTIAQNH*K*SAAY
Frame 2
EPRRKQACVEFLSAPHLGINRKRQAPSPARHLPL*RGLPCTAFRKLPRDPFPVRRPGWAWGRALGS
SSTFVTSNLLLGHFRELPSVSV*CKSFRGGAQR
AAAGTRSTRVQVRPCRMLAAAWPGAPVF*GPEGQ
PLHPRHGLRALAGRLTGAGTAAAQVPHPGTARP
RESRAGGPRMLPEAGPAERWTWTG*DGSDLSLA
RRLPRRDSARVGAQACPGSSMPEAGFQATNAFTE
CKFTCTSGKCLYLGSLVCNQQNDCGDNSDEENC
LLVTEHPPPGIFNSELEFAQIIIIVVVVTVMVV
VIVCLLNHYKVSTRSFINRPNQSRRREDGLPQEG
CLWPSDSAAPRLGASEIMHAPRSRDRFTAPSFI
QRDRFSRFQPTYPYVQHEIDLPPTISLSDGEEP
PPYQGPCTLQLRDPEQQMELNRESVRAPPNRTIF
DSDLIDIAMYSGGPCPPSSNSGISASTCSSNGR
MEGPPPTYSEVMGHHPGASFLHHQRSNAHRGSR
LQFQQNNAESTIVPIKGKDRKPGNLV*FLPTCTS
AGERNQEGKRPLGPSCAQCCSVSHGTNK*NQMS
KHGLCF*FLLGELHAN*TEMIQTSIWSDRKQCL
FGDRGWDGGVGRGKQRTGCFEDTMK*NPQRYLMY
LIVKGDFADK*GQNGMFYN*LNKEGSIIIYYCG
EEPASSLFLLRCGTFILF*KYESKFLCCVPRYK
VEKLDECKELLCVVMMCFKSCTILMLKIFTRELF
YVKFCMLSFHLWIVIRPKEYPGVVPRSIQEKIF
GDVA*HFTNLRKSKKSLLLQEFASNSSASLKLL
ETFGWKIR*GRLSSSISDLLF*VTLLLLGCIVYE
KMNTCIYGSSIMQCCPHPPAVQFLQ*FRFFSL*
HEIYSNTYLILCNKLFKMQGGYSAYC*NM*LLS
IFPLPLPLSSTA*FSSAGLLSSQEAPSSHPTSSL
HRTSCGSGVGGGFLCFGSP*K**RKNAMLLIVV
ISHCGLLYVTSISIAFLKECSAQNLPKFPQDST
KPFPRPAFVLKARTGQSENSGGGK*LKSTG*KAQ
HAVKMQLEN*F*ILLVLIFLIFTNIHSYIQ*KK
*LSSADVSTGFYKSSSQHV*QTLRVEKGLSAVH
SAMWRVGLCGLFT*QDELE**FHDSHLCSLKAKS
ACVCLCLSVGLEGDPSVRWLCAVTGETVPNPKS
CLILVCSLLLLTSVDRSLVFVCLF*GLEFPLHS
SFAHSNIHRTSPTLKRREEKHRHQLSAHAYNLCG
SIYS*ESQWRF*DWIQSCSSDSWKASAGETPAL
RAEIGLGPEGPSPTLETP*RFTGSPD*PLFLCQ
AKMRSPCSHRALLAGTCSGFLVRCAHRCGGEVSD
SIISVLTCSFGEAGDAPHSSSSQMASQSLLLYL
PQEGAQSRDL*IP**L*VYECVAHVHSIGEIIT
*FRYL*SSFKKEAPPIQPP*RTAFVK*LFKDSYI
SNHDFERSSRLGLCNELV*KPRS*HELMVNFPS
AEGKGDLDQ*LF*RLWLTCSYRVASWLVWR*KS
SDWEDTTYTVGPIVLSRTLFLAYRTHGSSLVTSD
LGNQ**VYNLRLFQQSVDCIVRKNIWWE*TLLG
IPLTFVPCSRCRRPKAS*IPSIRTQSSSIRLLF
QKL*HSL*ILTQSLMEKRFHEANYVFQ*FFYF*C
PKFTNTEA*QACPHPPHHINTWTHTQATRNPKR
AEANF*KIYREDCISIH*FWLKLMRQEIGANSK
WGRPPDTSRGILYPGEDFLNFCVSPFDLFHLYFI
FIRMRKAQKEALLEIFSDLEESIQIPAFLSEPT
VPFSDRGHPLSSIQRLFFLGRLWCRALQICPQA
RY*LLVERHPAPSPKPSLKGPAHGVGHWQAQRHS
AVGAGSPAPHAAMTGCAPISGACCTACLLNFAT
*NGNINFVYHSFFKNFPKLGSV*KKKLGKILGF
C*LLCCLLK*LKPVLGAKPSCHEHAPQPALCSPA
HTDQECRVLGLLR*KDN*MTGGQRENFPFLVRG
KSQI*KCCFQPRS*MLVLSSCVAYRSPFPPPPA
ASTATDHRDVNRQWKALLALQWSTFFRNQYFSIL
YYPARCVLCRVQVYVTARVRQSFAAAAAAAASR
TGCIRKLLSECRNVLLRKQCLPSSFSFFPLRVL
VFV*CGRGLEL*RLYIHYPCTLYICRYTPIMSEI
CMSVFQQLRCLMF*VQQI*EPSRPLLHLMLPPL
LCLT*NGAFFSCLSFLMFLFVRCCI*VEYIMHI
SYPMGRTKSC*YCNIMYR*YQF*QKWHRICECLC
ALSSFVRKFANGCIQIKVYVVYFPIKYQYYNTR
ERSVNKQATVYDQRIYSNGKLHLCCENTLKKIL
FKKSHSFLVATRRFLF*SF**CSAGPVLVIFESE
KCCFSTCFIISCIYLLL*HHEGVRQQ*KVHIFV
VAETVSEE*VNQPAAEDFVQLQRHL*PSVSKSL
CAFFFYKLKLWSQ*SNSRDCRERIPQEKQIHLQE
DPVLRKCV*LWVSTRRDLAVSQPSEGPLIHSHS
CPIIIRTQKANSVLPSVRNYVLDCILLHLSSGL
VFSV*L*PLHLSSNTLILKQKNKKSL*HHVH*NH
G*ILGVGILSSVVHKSSSWNFAHLTHIISLFCH
QSRV**IPKFLFAPWCMF*L*KCQIL*SYP*HP
GNK*QIIFKLKLTLQCNP*C*MD*KSQPF*YLFE
RAVKS*HFCCCGSCVSRPTCCFHRIL*GAPLGI
HH*ELRLTVVRNKAPTPQVQPCGRTVEHENVLD
SEVLKFVTTSLLPFYRTN*GLNFTVNDTGSF*CA
CWYVAIFHFIAFKNHANCILV*FKAILKYVQYY
SQHLVRLIFIIKQSTKKVQLYLNFSIVVCEL**
SKVIKVFFNKHSCLLFNIIPSYIQKKISTCHVSA
SFT*AMV*FLDLRSVIAILLKKDVALSAVC*L*
NQIFLLVLNAVVKP*HKIIKNNQRH
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