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Sequences

Sequence XM_371717

ACCAGCAGGACTGATGTGCACACAGAAGGAATGAAGTATGGATGTGAAAGAACGCAGGCCTTACTGCTCCCTGACCAAGAGCAGACGAGAGAAGGAACGG
CGCTACACAAATTCCTCCGCAGACAATGAGGAGTGCCGGGTACCCACACAGAAGTCCTACAGTTCCAGCGAGACATTGAAAGCTTTTGATCATGATTCCT
CGCGGCTGCTTTACGGCAACAGAGTGAAGGATTTGGTTCACAGAGAAGCAGACGAGTTCACTAGACAAGGACAGAATTTTACCCTAAGGCAGTTAGGAGT
TTGTGAACCAGCAACTCGAAGAGGACTGGCATTTTGTGCGGAAATGGGGCTCCCTCACAGAGGTTACTCTATCAGTGCAGGGTCAGATGCTGATACTGAA
AATGAAGCAGTGATGTCCCCAGAGCATGCCATGAGACTTTGGGGCAGGGGGGTCAAATCAGGCCGCAGCTCCTGCCTGTCAAGTCGGTCCAACTCAGCCC
TCACCCTGACAGATACGGAGCACGAAAACAAGTCCGACAGTGAGAATGAGCAACCTGCAAGCAATCAAGGCCAGTCTACCCTGCAGCCCTTGCCGCCTTC
CCATAAGCAGCACTCTGCACAGCATCATCCATCCATCACTTCTCTCAACAGAAACTCCCTGACCAATAGAAGGAACCAGAGTCCGGCCCCGCCGGCTGCT
TTGCCCGCCGAGCTGCAAACCACACCCGAGTCCGTCCAGCTGCAGGACAGCTGGGTCCTTGGCAGTAATGTACCACTGGAAAGCAGGCATTTCCTATTCA
AAACAGGAACAGGTACAACGCCACTGTTCAGTACTGCAACCCCAGGATACACAATGGCATCTGGCTCTGTTTATTCACCACCTACTCGGCCACTACCTAG
AAACACCCTATCAAGAAGTGCTTTTAAATTCAAGAAGTCTTCAAAGTACTGTAGCTGGAAATGCACTGCACTGTGTGCCGTAGGGGTCTCGGTGCTCCTG
GCAATACTCCTGTCTTATTTTATAGCAATGCATCTCTTTGGCCTCAACTGGCAGCTACAGCAGACTGAAAATGACACATTTGAGAATGGAAAAGTGAATT
CTGATACCATGCCAACAAACACTGTGTCATTACCTTCTGGAGACAATGGAAAATTAGGTGGATTTACGCAAGAAAATAACACCATAGATTCCGGAGAACT
TGATATTGGCCGAAGAGCAATTCAAGAGATTCCTCCCGGGATCTTCTGGAGATCACAGCTCTTCATTGATCAGCCACAGTTTCTTAAATTCAATATCTCT
CTTCAGAAGGATGCATTGATTGGAGTATATGGCCGGAAAGGCTTACCGCCTTCCCATACTCAGTATGACTTCGTGGAGCTCCTGGATGGCAGCAGGCTGA
TTGCCAGAGAGCAGCGGAGCCTGCTTGAGACGGAGAGAGCCGGGCGGCAGGCGAGATCCGTCAGCCTTCATGAGGCCGGCTTTATCCAGTACTTGGATTC
TGGAATCTGGCATCTGGCTTTTTATAATGATGGGAAAAATGCAGAGCAGGTGTCTTTTAATACCATTGTTATAGAGTCTGTGGTGGAATGTCCCCGAAAT
TGCCATGGAAATGGAGAATGCGTTTCTGGAACTTGCCATTGTTTTCCAGGATTTCTGGGTCCGGATTGTTCAAGAGCCGCCTGTCCAGTGTTATGTAGTG
GCAACGGGCAGTACTCCAAGGGCCGCTGCCTGTGTTTCAGCGGCTGGAAGGGCACCGAGTGTGATGTGCCGACTACCCAGTGTATTGACCCACAGTGTGG
GGGTCGTGGGATTTGTATCATGGGCTCTTGTGCTTGCAACTCAGGATACAAAGGAGAAAGTTGTGAAGAAGCTGACTGTATAGACCCTGGGTGTTCTAAT
CATGGTGTGTGTATCCACGGGGAATGTCACTGCAGTCCAGGATGGGGAGGTAGCAATTGTGAAATACTGAAGACCATGTGTCCAGACCAGTGCTCCGGCC
ACGGAACGTATCTTCAAGAAAGTGGCTCCTGCACGTGTGACCCTAACTGGACTGGCCCAGACTGCTCAAACGAAATATGTTCTGTGGACTGTGGCTCACA
CGGCGTTTGCATGGGGGGGACGTGTCGCTGTGAAGAAGGCTGGACGGGCCCAGCCTGTAATCAGAGAGCCTGCCACCCCCGCTGTGCCGAGCACGGGACC
TGCAAGGATGGCAAGTGTGAATGCAGCCAGGGCTGGAATGGAGAGCACTGCACTATCGAGGGTTGTCCTGGTCTGTGCAACAGCAATGGAAGATGTACCC
TGGACCAAAATGGCTGGCATTGTGTGTGCCAGCCTGGATGGAGAGGAGCAGGCTGTGACGTAGCCATGGAGACTCTTTGCACAGATAGCAAGGACAATGA
AGGAGATGGACTCATTGACTGCATGGATCCCGATTGCTGCCTACAGAGTTCCTGCCAGAATCAGCCCTATTGTCGGGGACTGCCGGATCCTCAGGACATC
ATTAGCCAAAGCCTTCAATCGCCTTCTCAGCAAGCTGCCAAATCCTTTTATGATCGAATCAGTTTCCTTATAGGATCTGATAGCACCCATGTTATACCTG
GAGAAAGTCCTTTCAATAAGAGCCTTGCATCTGTCATCAGAGGCCAAGTACTGACTGCTGATGGAACTCCACTTATTGGAGTAAATGTCTCGTTTTTCCA
TTACCCAGAATATGGATATACTATTACCCGCCAGGACGGAATGTTTGACTTGGTGGCAAATGGTGGGGCCTCTCTAACTTTGGTATTTGAACGATCCCCA
TTCCTCACTCAGTATCATACTGTGTGGATTCCATGGAATGTCTTTTATGTGATGGATACCCTAGTCATGAAGAAAGAAGAGAATGATATTCCCAGCTGTG
ATCTGAGTGGATTCGTGAGGCCAAATCCCATCATTGTGTCATCACCTTTATCCACCTTTTTCAGATCTTCTCCTGAAGACAGTCCCATCATTCCCGAAAC
ACAGGTACTCCACGAGGAAACTACAATTCCAGGAACAGATTTGAAACTCTCCTACTTGAGTTCCAGAGCTGCAGGGTATAAGTCAGTTCTCAAGATCACC
ATGACCCAGTCTATTATTCCATTTAATTTAATGAAGGTTCATCTTATGGTAGCTGTAGTAGGAAGACTCTTCCAAAAGTGGTTTCCTGCCTCACCAAACT
TGGCCTATACTTTCATATGGGATAAAACAGATGCATATAATCAGAAAGTCTATGGTCTATCTGAAGCTGTTGTGTCAGTTGGATATGAGTATGAGTCGTG
TTTGGACCTGACTCTGTGGGAAAAGAGGACTGCCATTCTGCAGGGCTATGAATTGGATGCGTCCAACATGGGTGGCTGGACATTAGATAAACATCACGTG
CTGGATGTACAGAACGGTATACTGTACAAGGGAAACGGGGAAAACCAGTTCATCTCCCAGCAGCCTCCAGTCGTGAGTAGCATCATGGGCAATGGGCGAA
GGCGCAGCATTTCCTGCCCCAGTTGCAATGGTCAAGCTGATGGTAACAAGTTACTGGCCCCAGTGGCGCTAGCTTGTGGGATCGATGGCAGTCTGTACGT
AGGCGATTTCAAC
TATGTGCGGCGGATATTCCCTTCTGGAAATGTAACAAGTGTCTTAGAACTAAGCAGCAACCCAGCTCATAGATACTACCTTGCAACG
GATCCAGTCACGGGAGATCTGTACGTTTCTGACACAAACACCCGCAGAATTTATCGCCCAAAGTCACTTACGGGGGCAAAAGACTTGACTAAAAATGCAG
AAGTCGTCGCAGGGACAGGGGAGCAATGCCTTCCGTTTGACGAGGCGAGATGTGGGGATGGAGGGAAGGCCGTGGAAGCCACACTCATGAGTCCCAAAGG
AATGGCAGTTGATAAGAATGGATTAATCTACTTTGTTGATGGAACCATGATTAGGAAAGTTGACCAAAATGGAATCATATCAACTCTTCTGGGCTCTAAC
GATTTGACTTCAGCCAGACCTTTAACTTGTGACACCAGCATGCACATCAGCCAGGTACGTCTGGAATGGCCCACTGACCTAGCCATTAACCCTATGGATA
ACTCCATTTATGTCCTGGATAATAATGTAGTTTTACAGATCACTGAAAATCGTCAAGTTCGCATTGCTGCTGGACGGCCCATGCACTGTCAGGTTCCCGG
AGTGGAATATCCTGTGGGGAAGCACGCGGTGCAGACAACACTGGAATCAGCCACTGCCATTGCTGTGTCCTACAGTGGGGTCCTGTACATTACTGAAACT
GATGAGAAGAAAATTAACCGGATAAGGCAGGTCACAACAGATGGAGAAATCTCCTTAGTGGCCGGAATACCTTCAGAGTGTGACTGCAAAAATGATGCCA
ACTGTGACTGTTACCAGAGTGGAGATGGCTACGCCAAGGATGCCAAACTCAGTGCCCCATCCTCCCTGGCTGCTTCTCCAGATGGTACACTGTATATTGC
AGATCTAGGGAATATCCGGATCCGGGCTGTGTCAAAGAATAAGCCTTTACTTAACTCTATGAACTTCTATGAAGTTGCGTCTCCAACTGATCAAGAACTC
TACATCTTTGACATCAATGGTACTCACCAATATACTGTAAGTTTAGTCACTGGTGATTACCTTTACAATTTTAGCTACAGCAATGACAATGATATTACTG
CTGTGACAGACAGCAATGGCAACACCCTTAGAATTAGACGGGACCCAAATCGCATGCCAGTTCGAGTGGTGTCTCCTGATAACCAAGTGATATGGTTGAC
AATAGGAACAAATGGATGTTTGAAAAGCATGACTGCTCAAGGACTGGAATTAGTTTTGTTTACTTACCATGGCAATAGTGGCCTTTTAGCCACTAAAAGT
GATGAAACTGGATGGACAACGTTTTTTGACTATGACAGTGAAGGTCGTCTGACAAATGTTACGTTTCCAACTGGAGTGGTCACAAACCTGCATGGGGACA
TGGACAAGGCTATCACAGTGGACATTGAGTCATCTAGCCGAGAAGAAGATGTCAGCATCACTTCAAATCTGTCCTCGATCGATTCTTTCTACACCATGGT
TCAAGATCAGTTAAGAAACAGCTACCAGATTGGTTATGACGGCTCCCTCAGAATTATCTACGCCAGTGGCCTGGACTCACACTACCAAACAGAGCCGCAC
GTTCTGGCTGGCACCGCTAATCCGACGGTTGCCAAAAGAAACATGACTTTGCCTGGCGAGAACGGTCAAAACTTGGTGGAATGGAGATTCCGAAAAGAGC
AAGCCCAAGGGAAAGTCAATGTCTTTGGCCGCAAGCTCAGGGTTAATGGCAGAAACCTCCTTTCAGTTGACTTTGATCGAACAACAAAGACAGAAAAGAT
CTATGACGACCACCGTAAATTTCTACTGAGGATCGCCTACGACACGTCTGGGCACCCGACTCTCTGGCTGCCAAGCAGCAAGCTGATGGCCGTCAATGTC
ACCTATTCATCCACAGGTCAAATTGCCAGCATCCAGCGAGGCACCACTAGCGAGAAAGTAGATTATGACGGACAGGGGAGGATCGTGTCTCGGGTCTTTG
CTGATGGTAAAACATGGAGTTACACATATTTAGAAAAGTCCATGGTTCTTCTGCTTCATAGCCAGCGGCAGTACATCTTCGAATACGATATGTGGGACCG
CCTGTCTGCCATCACCATGCCCAGTGTGGCTCGCCACACCATGCAGACCATCCGATCCATTGGCTACTACCGCAACATATACAACCCCCCGGAAAGCAAC
GCCTCCATCATCACGGACTACAACGAGGAAGGGCTGCTTCTACAAACAGCTTTCTTGGGTACAAGTCGGAGGGTCTTATTCAAATACAGAAGGCAGACTA
GGCTCTCAGAAATTTTATATGATAGCACAAGAGTCAGTTTTACCTATGATGAAACAGCAGGAGTCCTAAAGACAGTAAACCTCCAGAGTGATGGTTTTAT
TTGCACCATTAGATACAGGCAAATTGGTCCCCTGATTGACAGGCAGATTTTCCGCTTTAGTGAAGATGGGATGGTAAATGCAAGATTTGACTATAGCTAT
GACAACAGCTTTCGAGTGACCAGCATGCAGGGTGTGATCAATGAAACGCCACTGCCTATTGATCTGTATCAGTTTGATGACATTTCTGGCAAAGTTGAGC
AGTTTGGAAAGTTTGGAGTTATATATTATGATATTAACCAGATCATTTCTACAGCTGTAATGACCTATACGAAGCACTTTGATGCTCATGGCCGTATCAA
GGAGATTCAATATGAGATATTCAGGTCGCTCATGTACTGGATTACAATTCAGTATGATAACATGGGTCGGGTAACCAAGAGAGAGATTAAAATAGGGCCC
TTTGCCAACACCACCAAATATGCTTATGAATATGATGTTGATGGACAGCTCCAAACAGTTTACCTCAATGAAAAGATAATGTGGCGGTACAACTACGATC
TGAATGGAAACCTCCATTTACTGAACCCAAGTAACAGTGCGCGTCTGACACCCCTTCGCTATGACCTGCGAGACAGAATCACTCGACTGGGTGATGTTCA
ATATCGGTTGGATGAAGATGGTTTCCTACGTCAAAGGGGCACGGAAATCTTTGAATATAGCTCCAAGGGGCTTCTAACTCGAGTTTACAGTAAAGGCAGT
GGCTGGACAGTGATCTACCGTTATGACGGCCTGGGAAGGCGTGTTTCTAGCAAAACCAGTCTAGGACAGCACCTGCAGTTTTTTTATGCTGACTTAACTT
ATCCCACTAGGATTACTCATGTCTACAACCATTCGAGTTCAGAAATTACCTCCCTGTATTATGATCTCCAAGGACATCTTTTTGCCATGGAAATCAGCAG
TGGGGATGAATTCTATATTGCATCGGATAACACAGGGACACCACTGGCTGTGTTCAGTAGCAATGGGCTTATGCTGAAACAGATTCAGTACACTGCATAT
GGGGAAATCTATTTTGACTCTAATATTGACTTTCAACTGGTAATTGGATTTCATGGTGGCCTGTATGACCCACTCACCAAATTAATCCACTTTGGAGAAA
GAGATTATGACATTTTGGCAGGACGGTGGACAACACCTGACATAGAAATCTGGAAAAGAATTGGGAAGGACCCAGCTCCTTTTAACTTGTACATGTTTAG
GAATAACAACCCTGCAAGCAAAATCCATGACGTGAAAGATTACATCACAGATGTTAACAGCTGGCTGGTGACATTTGGTTTCCATCTGCACAATGCTATT
CCTGGATTCCCTGTTCCCAAATTTGATTTAACAGAACCTTCTTACGAACTTGTGAAGAGTCAGCAGTGGGATGATATACCGCCCATCTTCGGAGTCCAGC
AGCAAGTGGCGCGGCAGGCCAAGGCCTTCCTGTCGCTGGGGAAGATGGCCGAGGTGCAGGTGAGCCGGCGCCGGGCCGGCGGCGCGCAGTCCTGGCTGTG
GTTCGCCACGGTCAAGTCGCTGATCGGCAAGGGCGTCATGCTGGCCGTCAGCCAGGGCCGCGTGCAGACCAACGTGCTCAACATCGCCAACGAGGACTGC
ATCAAGGTGGCGGCCGTGCTCAACAACGCCTTCTACCTGGAGAACCTGCACTTCACCATCGAGGGCAAGGACACGCACTACTTCATCAAGACCACCACGC
CCGAGAGCGACCTGGGCACGCTGCGGTTGACCAGCGGCCGCAAGGCGCTGGAGAACGGCATCAACGTGACGGTGTCGCAGTCCACCACGGTGGTGAACGG
CAGGACGCGCAGGTTCGCGGACGTGGAGATGCAGTTCGGCGCGCTGGCGCTGCACGTGCGCTACGGCATGACCCTGGACGAGGAGAAGGCGCGCATCCTG
GAGCAGGCGCGGCAGCGCGCGCTCGCCCGGGCCTGGGCGCGCGAGCAGCAGCGCGTGCGCGACGGCGAGGAGGGCGCGCGCCTCTGGACGGAGGGCGAGA
AGCGGCAGCTGCTGAGCGCCGGCAAGGTGCAGGGCTACGACGGGTACTACGTACTCTCGGTGGAGCAGTACCCCGAGCTGGCCGACAGCGCCAACAACAT
CCAGTTCCTGCGGCAGAGCGAGATCGGCAGGAGGTAACGCCCGGGCCGCGCCCGCCGAGCCGCTCACGCCCTGCCCACATTGTCCTGTGGCACAACCCGA
GTGGGACTCTCCAACGCCCAAGAGCCTTCCTCCCGGGGGAATGAGACTGCTGTTACGACCCACACCCACACCGCGAAAACAAGGACCGCTTTTTTCCGAA
TGACCTTAAAGGTGATCGGCTTTAACGAATATGTTTACATATGCATAGCGCTGCACTCAGTCGGACTGAACGTAGCCAGAGGAAAAAAAAATCATCAAGG
ACAAAGGCCTCGACCTGTTGCGCTGGGCCGTCTGTTCCTTCTAGGCACTGTATTTAACTAACTTTAAAAAAGAAAAAAAAATGTGTACAGTGTTTCCAAA
TAGTCCCGAATTGTCGACCTTTGCTTACAAGAAGTAGTCTGTCTGCATAGGATGTGATAGCTATCTCTGTTCATTTTACAATGTGGGGCAAAGTTACTGT
TTCTAGACAACCCAACTGCTTTCCCTGTGCAGCTTTGTAGAAGGACATTGGCACAGTGACTTCTGCGGCGGGGATTTATTAATGGATTTTACAATGCTAA
CGTGGTTTCCCTTCGGGGAAAAAACTGGCAACTAGAATCCTTGTCACTGATAAGCAAAGGAAATCCTGATTTTTTTGTAAATTATGTGAGACAAGTTGTT
TATGGATTTTTATATGAATTACAATTTACTGTACATCAAATCTTAGTCTCAGAGGAGTTAATTTATGTAAAGTGTTTAAAAATTTATACTTAAAAATAAA
ATGATAAAAACGTGAACTGTGTGATTTTTTTAAAAGGATTGCACCTTTTGTTATCTGTTATAGCTGTACAGTATGAATTATTATATTGTAGAGATATAAC
AACTTATGCCTATAATGTCCAGAAGTGTTAATATTTTTGTATTAGGTTGAAAAAATGTGCAAGCTTCTATCACTAGATGGATAGGACCGTGCAATTCTAG
GTGGGTGGCGAATCAGAGAGCTCCTTTCTCTTCCCTCTCTCACGCATCAGGCCAGTGTCCTCAGCATTGTCAACTGAGAGGCACAGTAGACAACTAGGGC
TGGTGGAATGTAAGGGAAGAAGATTGAAAAAACGGGAGGAAGGGTTCTCTGGCCCTCTCTCAACCTTGCAAGTCAATGGGGAGTTGTTGATATAATTAAC
CCCGAGGTTTTTACTGTTACTGTTCCAAAGCTCTGTCTCTTGATGGAGGAGAGACCACATCAGATGCTGGGGAAATAGGAGGAGGAAAGGTTCTGATGTA
GTCGTGATCCTAAACACGTGTCTTAAGATCTAGGAAAGACAGCAGAAACCGAGCAGTGGTGGGTGAGCCAGATGGAGCCGGTCAGGGTTACTCTAAGCCC
ACATGACCAAACCATCTTGGGGGGCTGGTTTGAATGACAGCCTCTGCTCTGTCTCGGGGAAGCCGGGGGTGGCAGATCCAGCTGGAAGTGAACTGACAGC
CGCGCCCTCCTGCACACATGCATGCACGCGTGTGGGAACGAGCCCAGCCGCCATCTGCACTTCCGTGTCGGCTCAGCTCTGACAAATCTCTTTCCTGAGC
ACTAAATTCAGCCACGAAAATATTTTTAGAAGATATTTCTCAGTTCATCGAGCTATAGTACACACTGTTTTCCTCTATGTATAATGGTGATAAAATATAG
CAAGTGAACATGTCGTAAATATAAAGGTTCAAGTGATGTATTGAAAATAATTTTCTAACTGCTTTGTATGTATCACATACTCTAAATTGCACAGTAGGCG
TGTTTATTAAACAGATGATTGGCTGGGAAAGTTTCAAAATAGCTACTGAATTTACAGTATCAGTGCTATTACTGTCTTTGTGTATTTGGTAGAGCATACC
GAAGTAATTAATCTTCTAATGAATGCTGATGATATTTTATTAGAATGAAAGCACAGATTAGCATTAATATTTTTTATTCTGGAAATCCTTTGGCAAGTAT
TATGAAGCCCAAATTTAGAAAACTATGAGATTTCAAACCACATAAACATGATTCTGTTTTCCATTTTATTTTTTAACTGTTAGGTATTTGCAGTTCTGTT
CCGTGGAACTTCTGCAGGCCTGTATTTAGCATGCTGTAAGTACTTTTGGGTGAAATAGGCTCTGAGTCTAAATTCTCAGACATGTTTCTGATGTATTACC
ATGAAAAGCTTGTGCCACATGACAGAAGTGAGATCATAGTCTTAACCTCTTCTTGACGTGGACTGGTCTTCACTCGGGCACCGATAAATAACAGATTTGG
AGTATCTCCTGGTGCTTATTTTAGATGATGAAGTCAAATCAACCCAATTAGTGTCCTGTTAGTAGGTATAATGAGCCTATTTCTTTCTAAAAAGACTTGT
GATCTGGACATGCTTTTACAAGAAATAGTGACCTTGGGGAATATGTAAACAAAAGACCTTTTTCTAAGAGTTGGGAGGGGGTGGGGGACTGTATAATGAA
AAGAATTAGCTTACAAAAAAGAAATTGATATTCAAAGTATTTTAGGCAAAGCCAGTCAAAATGCTTTCATGATATTTTGAGATGTAAATTTTGTCTGATT
TGTATTGTTCTTTTCATTTGCCTTCTTAACTTTATATGTGACCTGAATTTTCCATAACTTGATGACTATAGATTGCACCTAGGCATTCCAATAAAAGCCA
ACCCAATGTG
  • refseq_ODZ3.F1 (forward primer)
  • refseq_ODZ3.R1 (reverse primer)
  • Single exon skipping

Frame 0

TSRTDVHTEGMKYGCERTQALLLPDQEQTREGT
ALHKFLRRQ*GVPGTHTEVLQFQRDIESF*S*FL
AAALRQQSEGFGSQRSRRVH*TRTEFYPKAVRS
L*TSNSKRTGILCGNGAPSQRLLYQCRVRC*Y*
K*SSDVPRACHETLGQGGQIRPQLLPVKSVQLSP
HPDRYGARKQVRQ*E*ATCKQSRPVYPAALAAF
P*AALCTASSIHHFSQQKLPDQ*KEPESGPAGC
FARRAANHTRVRPAAGQLGPWQ*CTTGKQAFPIQ
NRNRYNATVQYCNPRIHNGIWLCLFTTYSATT*
KHPIKKCF*IQEVFKVL*LEMHCTVCRRGLGAP
GNTPVLFYSNASLWPQLAATAD*K*HI*EWKSEF
*YHANKHCVITFWRQWKIRWIYARK*HHRFRRT
*YWPKSNSRDSSRDLLEITALH*SATVS*IQYL
SSEGCIDWSIWPERLTAFPYSV*LRGAPGWQQAD
CQRAAEPA*DGESRAAGEIRQPS*GRLYPVLGF
WNLASGFL**WEKCRAGVF*YHCYRVCGGMSPK
LPWKWRMRFWNLPLFSRISGSGLFKSRLSSVM*W
QRAVLQGPLPVFQRLEGHRV*CADYPVY*PTVW
GSWDLYHGLLCLQLRIQRRKL*RS*LYRPWVF*
SWCVYPRGMSLQSRMGR*QL*NTEDHVSRPVLRP
RNVSSRKWLLHV*P*LDWPRLLKRNMFCGLWLT
RRLHGGDVSL*RRLDGPSL*SESLPPPLCRARD
LQGWQV*MQPGLEWRALHYRGLSWSVQQQWKMYP
GPKWLALCVPAWMERSRL*RSHGDSLHR*QGQ*
RRWTH*LHGSRLLPTEFLPESALLSGTAGSSGH
H*PKPSIAFSASCQILL*SNQFPYRI**HPCYTW
RKSFQ*EPCICHQRPSTDC*WNSTYWSKCLVFP
LPRIWIYYYPPGRNV*LGGKWWGLSNFGI*TIP
IPHSVSYCVDSMECLLCDGYPSHEERRE*YSQL*
SEWIREAKSHHCVITFIHLFQIFS*RQSHHSRN
TGTPRGNYNSRNRFETLLLEFQSCRV*VSSQDH
HDPVYYSI*FNEGSSYGSCSRKTLPKVVSCLTKL
GLYFHMG*NRCI*SESLWSI*SCCVSWI*V*VV
FGPDSVGKEDCHSAGL*IGCVQHGWLDIR*TSR
AGCTERYTVQGKRGKPVHLPAASSRE*HHGQWAK
AQHFLPQLQWSS*W*QVTGPSGASLWDRWQSVR
RRFQ
LCAADIPFWKCNKCLRTKQQPSS*ILPCN
GSSHGRSVRF*HKHPQNLSPKVTYGGKRLD*KCR
SRRRDRGAMPSV*RGEMWGWREGRGSHTHESQR
NGS**EWINLLC*WNHD*ES*PKWNHINSSGL*
RFDFSQTFNL*HQHAHQPGTSGMAH*PSH*PYG*
LHLCPG**CSFTDH*KSSSSHCCWTAHALSGSR
SGISCGEARGADNTGISHCHCCVLQWGPVHY*N
**EEN*PDKAGHNRWRNLLSGRNTFRV*LQK*CQ
L*LLPEWRWLRQGCQTQCPILPGCFSRWYTVYC
RSREYPDPGCVKE*AFT*LYELL*SCVSN*SRT
LHL*HQWYSPIYCKFSHW*LPLQF*LQQ*Q*YYC
CDRQQWQHP*N*TGPKSHASSSGVS**PSDMVD
NRNKWMFEKHDCSRTGISFVYLPWQ*WPFSH*K
**NWMDNVF*L*Q*RSSDKCYVSNWSGHKPAWGH
GQGYHSGH*VI*PRRRCQHHFKSVLDRFFLHHG
SRSVKKQLPDWL*RLPQNYLRQWPGLTLPNRAA
RSGWHR*SDGCQKKHDFAWRERSKLGGMEIPKRA
SPRESQCLWPQAQG*WQKPPFS*L*SNNKDRKD
L*RPP*ISTEDRLRHVWAPDSLAAKQQADGRQC
HLFIHRSNCQHPARHH*RESRL*RTGEDRVSGLC
*W*NMELHIFRKVHGSSAS*PAAVHLRIRYVGP
PVCHHHAQCGSPHHADHPIHWLLPQHIQPPGKQ
RLHHHGLQRGRAASTNSFLGYKSEGLIQIQKAD*
ALRNFI**HKSQFYL**NSRSPKDSKPPE*WFY
LHH*IQANWSPD*QADFPL**RWDGKCKI*L*L
*QQLSSDQHAGCDQ*NATAY*SVSV**HFWQS*A
VWKVWSYIL*Y*PDHFYSCNDLYEAL*CSWPYQ
GDSI*DIQVAHVLDYNSV**HGSGNQERD*NRA
LCQHHQICL*I*C*WTAPNSLPQ*KDNVAVQLRS
EWKPPFTEPK*QCASDTPSL*PARQNHSTG*CS
ISVG*RWFPTSKGHGNL*I*LQGASNSSLQ*RQ
WLDSDLPL*RPGKACF*QNQSRTAPAVFLC*LNL
SH*DYSCLQPFEFRNYLPVL*SPRTSFCHGNQQ
WG*ILYCIG*HRDTTGCVQ*QWAYAETDSVHCI
WGNLF*L*Y*LSTGNWISWWPV*PTHQINPLWRK
RL*HFGRTVDNT*HRNLEKNWEGPSSF*LVHV*
E*QPCKQNP*RERLHHRC*QLAGDIWFPSAQCY
SWIPCSQI*FNRTFLRTCEESAVG*YTAHLRSPA
ASGAAGQGLPVAGEDGRGAGEPAPGRRRAVLAV
VRHGQVADRQGRHAGRQPGPRADQRAQHRQRGL
HQGGGRAQQRLLPGEPALHHRGQGHALLHQDHHA
RERPGHAAVDQRPQGAGERHQRDGVAVHHGGER
QDAQVRGRGDAVRRAGAARALRHDPGRGEGAHP
GAGAAARARPGLGARAAARARRRGGRAPLDGGRE
AAAAERRQGAGLRRVLRTLGGAVPRAGRQRQQH
PVPAAERDRQEVTPGPRPPSRSRPAHIVLWHNP
SGTLQRPRAFLPGE*DCCYDPHPHRENKDRFFPN
DLKGDRL*RICLHMHSAALSRTERSQRKKKSSR
TKASTCCAGPSVPSRHCI*LTLKKKKKCVQCFQ
IVPNCRPLLTRSSLSA*DVIAISVHFTMWGKVTV
SRQPNCFPCAAL*KDIGTVTSAAGIY*WILQC*
RGFPSGKKLATRILVTDKQRKS*FFCKLCETSC
LWIFI*ITIYCTSNLSLRGVNLCKVFKNLYLKIK
**KRELCDFFKRIAPFVICYSCTV*IIIL*RYN
NLCL*CPEVLIFLY*VEKMCKLLSLDG*DRAIL
GGWRIRELLSLPSLTHQASVLSIVN*EAQ*TTRA
GGM*GKKIEKTGGRVLWPSLNLASQWGVVDIIN
PEVFTVTVPKLCLLMEERPHQMLGK*EEERF*C
SRDPKHVS*DLGKTAETEQWWVSQMEPVRVTLSP
HDQTILGGWFE*QPLLCLGEAGGGRSSWK*TDS
RALLHTCMHACGNEPSRHLHFRVGSALTNLFPE
H*IQPRKYF*KIFLSSSSYSTHCFPLCIMVIKYS
K*TCRKYKGSSDVLKIIF*LLCMYHIL*IAQ*A
CLLNR*LAGKVSK*LLNLQYQCYYCLCVFGRAY
RSN*SSNEC**YFIRMKAQISINIFYSGNPLASI
MKPKFRKL*DFKPHKHDSVFHFIF*LLGICSSV
PWNFCRPVFSML*VLLGEIGSESKFSDMFLMYY
HEKLVPHDRSEIIVLTSS*RGLVFTRAPINNRFG
VSPGAYFR**SQINPISVLLVGIMSLFLSKKTC
DLDMLLQEIVTLGNM*TKDLFLRVGRGWGTV**
KELAYKKEIDIQSILGKASQNAFMIF*DVNFV*F
VLFFSFAFLTLYVT*IFHNLMTIDCT*AFQ*KP
TQC

Frame 1

PAGLMCTQKE*SMDVKERRPYCSLTKSRREKER
RYTNSSADNEECRVPTQKSYSSSETLKAFDHDS
SRLLYGNRVKDLVHREADEFTRQGQNFTLRQLGV
CEPATRRGLAFCAEMGLPHRGYSISAGSDADTE
NEAVMSPEHAMRLWGRGVKSGRSSCLSSRSNSA
LTLTDTEHENKSDSENEQPASNQGQSTLQPLPPS
HKQHSAQHHPSITSLNRNSLTNRRNQSPAPPAA
LPAELQTTPESVQLQDSWVLGSNVPLESRHFLF
KTGTGTTPLFSTATPGYTMASGSVYSPPTRPLPR
NTLSRSAFKFKKSSKYCSWKCTALCAVGVSVLL
AILLSYFIAMHLFGLNWQLQQTENDTFENGKVN
SDTMPTNTVSLPSGDNGKLGGFTQENNTIDSGEL
DIGRRAIQEIPPGIFWRSQLFIDQPQFLKFNIS
LQKDALIGVYGRKGLPPSHTQYDFVELLDGSRL
IAREQRSLLETERAGRQARSVSLHEAGFIQYLDS
GIWHLAFYNDGKNAEQVSFNTIVIESVVECPRN
CHGNGECVSGTCHCFPGFLGPDCSRAACPVLCS
GNGQYSKGRCLCFSGWKGTECDVPTTQCIDPQCG
GRGICIMGSCACNSGYKGESCEEADCIDPGCSN
HGVCIHGECHCSPGWGGSNCEILKTMCPDQCSG
HGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSH
GVCMGGTCRCEEGWTGPACNQRACHPRCAEHGT
CKDGKCECSQGWNGEHCTIEGCPGLCNSNGRCT
LDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNE
GDGLIDCMDPDCCLQSSCQNQPYCRGLPDPQDI
ISQSLQSPSQQAAKSFYDRISFLIGSDSTHVIP
GESPFNKSLASVIRGQVLTADGTPLIGVNVSFFH
YPEYGYTITRQDGMFDLVANGGASLTLVFERSP
FLTQYHTVWIPWNVFYVMDTLVMKKEENDIPSC
DLSGFVRPNPIIVSSPLSTFFRSSPEDSPIIPET
QVLHEETTIPGTDLKLSYLSSRAAGYKSVLKIT
MTQSIIPFNLMKVHLMVAVVGRLFQKWFPASPN
LAYTFIWDKTDAYNQKVYGLSEAVVSVGYEYESC
LDLTLWEKRTAILQGYELDASNMGGWTLDKHHV
LDVQNGILYKGNGENQFISQQPPVVSSIMGNGR
RRSISCPSCNGQADGNKLLAPVALACGIDGSLYV
GDFN
YVRRIFPSGNVTSVLELSSNPAHRYYLAT
DPVTGDLYVSDTNTRRIYRPKSLTGAKDLTKNA
EVVAGTGEQCLPFDEARCGDGGKAVEATLMSPKG
MAVDKNGLIYFVDGTMIRKVDQNGIISTLLGSN
DLTSARPLTCDTSMHISQVRLEWPTDLAINPMD
NSIYVLDNNVVLQITENRQVRIAAGRPMHCQVPG
VEYPVGKHAVQTTLESATAIAVSYSGVLYITET
DEKKINRIRQVTTDGEISLVAGIPSECDCKNDA
NCDCYQSGDGYAKDAKLSAPSSLAASPDGTLYIA
DLGNIRIRAVSKNKPLLNSMNFYEVASPTDQEL
YIFDINGTHQYTVSLVTGDYLYNFSYSNDNDIT
AVTDSNGNTLRIRRDPNRMPVRVVSPDNQVIWLT
IGTNGCLKSMTAQGLELVLFTYHGNSGLLATKS
DETGWTTFFDYDSEGRLTNVTFPTGVVTNLHGD
MDKAITVDIESSSREEDVSITSNLSSIDSFYTMV
QDQLRNSYQIGYDGSLRIIYASGLDSHYQTEPH
VLAGTANPTVAKRNMTLPGENGQNLVEWRFRKE
QAQGKVNVFGRKLRVNGRNLLSVDFDRTTKTEKI
YDDHRKFLLRIAYDTSGHPTLWLPSSKLMAVNV
TYSSTGQIASIQRGTTSEKVDYDGQGRIVSRVF
ADGKTWSYTYLEKSMVLLLHSQRQYIFEYDMWDR
LSAITMPSVARHTMQTIRSIGYYRNIYNPPESN
ASIITDYNEEGLLLQTAFLGTSRRVLFKYRRQT
RLSEILYDSTRVSFTYDETAGVLKTVNLQSDGFI
CTIRYRQIGPLIDRQIFRFSEDGMVNARFDYSY
DNSFRVTSMQGVINETPLPIDLYQFDDISGKVE
QFGKFGVIYYDINQIISTAVMTYTKHFDAHGRIK
EIQYEIFRSLMYWITIQYDNMGRVTKREIKIGP
FANTTKYAYEYDVDGQLQTVYLNEKIMWRYNYD
LNGNLHLLNPSNSARLTPLRYDLRDRITRLGDVQ
YRLDEDGFLRQRGTEIFEYSSKGLLTRVYSKGS
GWTVIYRYDGLGRRVSSKTSLGQHLQFFYADLT
YPTRITHVYNHSSSEITSLYYDLQGHLFAMEISS
GDEFYIASDNTGTPLAVFSSNGLMLKQIQYTAY
GEIYFDSNIDFQLVIGFHGGLYDPLTKLIHFGE
RDYDILAGRWTTPDIEIWKRIGKDPAPFNLYMFR
NNNPASKIHDVKDYITDVNSWLVTFGFHLHNAI
PGFPVPKFDLTEPSYELVKSQQWDDIPPIFGVQ
QQVARQAKAFLSLGKMAEVQVSRRRAGGAQSWLW
FATVKSLIGKGVMLAVSQGRVQTNVLNIANEDC
IKVAAVLNNAFYLENLHFTIEGKDTHYFIKTTT
PESDLGTLRLTSGRKALENGINVTVSQSTTVVNG
RTRRFADVEMQFGALALHVRYGMTLDEEKARIL
EQARQRALARAWAREQQRVRDGEEGARLWTEGE
KRQLLSAGKVQGYDGYYVLSVEQYPELADSANNI
QFLRQSEIGRR*RPGRARRAAHALPTLSCGTTR
VGLSNAQEPSSRGNETAVTTHTHTAKTRTAFFR
MTLKVIGFNEYVYICIALHSVGLNVARGKKNHQG
QRPRPVALGRLFLLGTVFN*L*KRKKNVYSVSK
*SRIVDLCLQEVVCLHRM**LSLFILQCGAKLL
FLDNPTAFPVQLCRRTLAQ*LLRRGFINGFYNAN
VVSLRGKNWQLESLSLISKGNPDFFVNYVRQVV
YGFLYELQFTVHQILVSEELIYVKCLKIYT*K*
NDKNVNCVIFLKGLHLLLSVIAVQYELLYCRDIT
TYAYNVQKC*YFCIRLKKCASFYH*MDRTVQF*
VGGESESSFLFPLSRIRPVSSALSTERHSRQLG
LVECKGRRLKKREEGFSGPLSTLQVNGELLI*LT
PRFLLLLFQSSVS*WRRDHIRCWGNRRRKGSDV
VVILNTCLKI*ERQQKPSSGG*ARWSRSGLL*A
HMTKPSWGAGLNDSLCSVSGKPGVADPAGSELTA
APSCTHACTRVGTSPAAICTSVSAQL*QISFLS
TKFSHENIFRRYFSVHRAIVHTVFLYV*W**NI
ASEHVVNIKVQVMY*K*FSNCFVCITYSKLHSRR
VY*TDDWLGKFQNSY*IYSISAITVFVYLVEHT
EVINLLMNADDILLE*KHRLALIFFILEILWQV
L*SPNLENYEISNHINMILFSILFFNC*VFAVLF
RGTSAGLYLACCKYFWVK*ALSLNSQTCF*CIT
MKSLCHMTEVRS*S*PLLDVDWSSLGHR*ITDL
EYLLVLILDDEVKSTQLVSC**V**AYFFLKRLV
IWTCFYKK**PWGICKQKTFF*ELGGGGGLYNE
KN*LTKKKLIFKVF*AKPVKMLS*YFEM*ILSD
LYCSFHLPS*LYM*PEFSIT**L*IAPRHSNKSQ
PNV

Frame 2

QQD*CAHRRNEVWM*KNAGLTAP*PRADERRNG
ATQIPPQTMRSAGYPHRSPTVPARH*KLLIMIP
RGCFTATE*RIWFTEKQTSSLDKDRILP*GS*E
FVNQQLEEDWHFVRKWGSLTEVTLSVQGQMLILK
MKQ*CPQSMP*DFGAGGSNQAAAPACQVGPTQP
SP*QIRSTKTSPTVRMSNLQAIKASLPCSPCRL
PISSTLHSIIHPSLLSTETP*PIEGTRVRPRRLL
CPPSCKPHPSPSSCRTAGSLAVMYHWKAGISYS
KQEQVQRHCSVLQPQDTQWHLALFIHHLLGHYL
ETPYQEVLLNSRSLQSTVAGNALHCVP*GSRCSW
QYSCLIL*QCISLASTGSYSRLKMTHLRMEK*I
LIPCQQTLCHYLLETMEN*VDLRKKITP*IPEN
LILAEEQFKRFLPGSSGDHSSSLISHSFLNSISL
FRRMH*LEYMAGKAYRLPILSMTSWSSWMAAG*
LPESSGACLRRREPGGRRDPSAFMRPALSSTWI
LESGIWLFIMMGKMQSRCLLIPLL*SLWWNVPEI
AMEMENAFLELAIVFQDFWVRIVQEPPVQCYVV
ATGSTPRAAACVSAAGRAPSVMCRLPSVLTHSV
GVVGFVSWALVLATQDTKEKVVKKLTV*TLGVLI
MVCVSTGNVTAVQDGEVAIVKY*RPCVQTSAPA
TERIFKKVAPARVTLTGLAQTAQTKYVLWTVAH
TAFAWGGRVAVKKAGRAQPVIREPATPAVPSTGP
ARMASVNAARAGMESTALSRVVLVCATAMEDVP
WTKMAGIVCASLDGEEQAVT*PWRLFAQIARTM
KEMDSLTAWIPIAAYRVPARISPIVGDCRILRTS
LAKAFNRLLSKLPNPFMIESVSL*DLIAPMLYL
EKVLSIRALHLSSEAKY*LLMELHLLE*MSRFS
ITQNMDILLPARTECLTWWQMVGPL*LWYLNDPH
SSLSIILCGFHGMSFM*WIP*S*RKKRMIFPAV
I*VDS*GQIPSLCHHLYPPFSDLLLKTVPSFPK
HRYSTRKLQFQEQI*NSPT*VPELQGISQFSRSP
*PSLLFHLI**RFILW*L**EDSSKSGFLPHQT
WPILSYGIKQMHIIRKSMVYLKLLCQLDMSMSR
VWT*LCGKRGLPFCRAMNWMRPTWVAGH*INITC
WMYRTVYCTRETGKTSSSPSSLQS*VASWAMGE
GAAFPAPVAMVKLMVTSYWPQWR*LVGSMAVCT
*AIST
MCGGYSLLEM*QVS*N*AATQLIDTTLQR
IQSREICTFLTQTPAEFIAQSHLRGQKT*LKMQ
KSSQGQGSNAFRLTRRDVGMEGRPWKPHS*VPK
EWQLIRMD*STLLMEP*LGKLTKMESYQLFWALT
I*LQPDL*LVTPACTSARYVWNGPLT*PLTLWI
TPFMSWIIM*FYRSLKIVKFALLLDGPCTVRFP
EWNILWGSTRCRQHWNQPLPLLCPTVGSCTLLKL
MRRKLTG*GRSQQMEKSP*WPEYLQSVTAKMMP
TVTVTRVEMATPRMPNSVPHPPWLLLQMVHCIL
QI*GISGSGLCQRISLYLTL*TSMKLRLQLIKNS
TSLTSMVLTNIL*V*SLVITFTILATAMTMILL
L*QTAMATPLELDGTQIACQFEWCLLITK*YG*
Q*EQMDV*KA*LLKDWN*FCLLTMAIVAF*PLKV
MKLDGQRFLTMTVKVV*QMLRFQLEWSQTCMGT
WTRLSQWTLSHLAEKKMSASLQICPRSILSTPW
FKIS*ETATRLVMTAPSELSTPVAWTHTTKQSRT
FWLAPLIRRLPKET*LCLARTVKTWWNGDSEKS
KPKGKSMSLAASSGLMAETSFQLTLIEQQRQKR
SMTTTVNFY*GSPTTRLGTRLSGCQAAS*WPSMS
PIHPQVKLPASSEAPLARK*IMTDRGGSCLGSL
LMVKHGVTHI*KSPWFFCFIASGSTSSNTICGT
ACLPSPCPVWLATPCRPSDPLATTATYTTPRKAT
PPSSRTTTRKGCFYKQLSWVQVGGSYSNTEGRL
GSQKFYMIAQESVLPMMKQQES*RQ*TSRVMVL
FAPLDTGKLVP*LTGRFSALVKMGW*MQDLTIAM
TTAFE*PACRV*SMKRHCLLICISLMTFLAKLS
SLESLELYIMILTRSFLQL**PIRSTLMLMAVS
RRFNMRYSGRSCTGLQFSMITWVG*PRERLK*GP
LPTPPNMLMNMMLMDSSKQFTSMKR*CGGTTTI
*METSIY*TQVTVRV*HPFAMTCETESLDWVMF
NIGWMKMVSYVKGARKSLNIAPRGF*LEFTVKAV
AGQ*STVMTAWEGVFLAKPV*DSTCSFFMLT*L
IPLGLLMSTTIRVQKLPPCIMISKDIFLPWKSA
VGMNSILHRITQGHHWLCSVAMGLC*NRFSTLHM
GKSILTLILTFNW*LDFMVACMTHSPN*STLEK
EIMTFWQDGGQHLT*KSGKELGRTQLLLTCTCL
GITTLQAKSMT*KITSQMLTAGW*HLVSICTMLF
LDSLFPNLI*QNLLTNL*RVSSGMIYRPSSESS
SKWRGRPRPSCRWGRWPRCR*AGAGPAARSPGC
GSPRSSR*SARASCWPSARAACRPTCSTSPTRTA
SRWRPCSTTPSTWRTCTSPSRARTRTTSSRPPR
PRATWARCG*PAAARRWRTAST*RCRSPPRW*T
AGRAGSRTWRCSSARWRCTCATA*PWTRRRRASW
SRRGSARSPGPGRASSSACATARRARASGRRAR
SGSC*APARCRATTGTTYSRWSSTPSWPTAPTT
SSSCGRARSAGGNARAAPAEPLTPCPHCPVAQPE
WDSPTPKSLPPGGMRLLLRPTPTPRKQGPLFSE
*P*R*SALTNMFTYA*RCTQSD*T*PEEKKIIK
DKGLDLLRWAVCSF*ALYLTNFKKEKKMCTVFPN
SPELSTFAYKK*SVCIGCDSYLCSFYNVGQSYC
F*TTQLLSLCSFVEGHWHSDFCGGDLLMDFTML
TWFPFGEKTGN*NPCH**AKEILIFL*IM*DKLF
MDFYMNYNLLYIKS*SQRS*FM*SV*KFILKNK
MIKT*TV*FF*KDCTFCYLL*LYSMNYYIVEI*
QLMPIMSRSVNIFVLG*KNVQASITRWIGPCNSR
WVANQRAPFSSLSHASGQCPQHCQLRGTVDN*G
WWNVREED*KNGRKGSLALSQPCKSMGSC*YN*
PRGFYCYCSKALSLDGGETTSDAGEIGGGKVLM*
S*S*TRVLRSRKDSRNRAVVGEPDGAGQGYSKP
T*PNHLGGLV*MTASALSRGSRGWQIQLEVN*Q
PRPPAHMHARVWERAQPPSALPCRLSSDKSLS*A
LNSATKIFLEDISQFIEL*YTLFSSMYNGDKI*
QVNMS*I*RFK*CIENNFLTALYVSHTLNCTVG
VFIKQMIGWESFKIATEFTVSVLLLSLCIW*SIP
K*LIF**MLMIFY*NESTD*H*YFLFWKSFGKY
YEAQI*KTMRFQTT*T*FCFPFYFLTVRYLQFC
SVELLQACI*HAVSTFG*NRL*V*ILRHVSDVLP
*KACAT*QK*DHSLNLFLTWTGLHSGTDK*QIW
SISWCLF*MMKSNQPN*CPVSRYNEPISF*KDL
*SGHAFTRNSDLGEYVNKRPFSKSWEGVGDCIMK
RISLQKRN*YSKYFRQSQSKCFHDILRCKFCLI
CIVLFICLLNFICDLNFP*LDDYRLHLGIPIKA
NPM

Sequence XM_931600

ACCAGCAGGACTGATGTGCACACAGAAGGAATGAAGTATGGATGTGAAAGAACGCAGGCCTTACTGCTCCCTGACCAAGAGCAGACGAGAGAAGGAACGG
CGCTACACAAATTCCTCCGCAGACAATGAGGAGTGCCGGGTACCCACACAGAAGTCCTACAGTTCCAGCGAGACATTGAAAGCTTTTGATCATGATTCCT
CGCGGCTGCTTTACGGCAACAGAGTGAAGGATTTGGTTCACAGAGAAGCAGACGAGTTCACTAGACAAGGACAGAATTTTACCCTAAGGCAGTTAGGAGT
TTGTGAACCAGCAACTCGAAGAGGACTGGCATTTTGTGCGGAAATGGGGCTCCCTCACAGAGGTTACTCTATCAGTGCAGGGTCAGATGCTGATACTGAA
AATGAAGCAGTGATGTCCCCAGAGCATGCCATGAGACTTTGGGGCAGGGGGGTCAAATCAGGCCGCAGCTCCTGCCTGTCAAGTCGGTCCAACTCAGCCC
TCACCCTGACAGATACGGAGCACGAAAACAAGTCCGACAGTGAGAATGAGCAACCTGCAAGCAATCAAGGCCAGTCTACCCTGCAGCCCTTGCCGCCTTC
CCATAAGCAGCACTCTGCACAGCATCATCCATCCATCACTTCTCTCAACAGAAACTCCCTGACCAATAGAAGGAACCAGAGTCCGGCCCCGCCGGCTGCT
TTGCCCGCCGAGCTGCAAACCACACCCGAGTCCGTCCAGCTGCAGGACAGCTGGGTCCTTGGCAGTAATGTACCACTGGAAAGCAGGCATTTCCTATTCA
AAACAGGAACAGGTACAACGCCACTGTTCAGTACTGCAACCCCAGGATACACAATGGCATCTGGCTCTGTTTATTCACCACCTACTCGGCCACTACCTAG
AAACACCCTATCAAGAAGTGCTTTTAAATTCAAGAAGTCTTCAAAGTACTGTAGCTGGAAATGCACTGCACTGTGTGCCGTAGGGGTCTCGGTGCTCCTG
GCAATACTCCTGTCTTATTTTATAGCAATGCATCTCTTTGGCCTCAACTGGCAGCTACAGCAGACTGAAAATGACACATTTGAGAATGGAAAAGTGAATT
CTGATACCATGCCAACAAACACTGTGTCATTACCTTCTGGAGACAATGGAAAATTAGGTGGATTTACGCAAGAAAATAACACCATAGATTCCGGAGAACT
TGATATTGGCCGAAGAGCAATTCAAGAGATTCCTCCCGGGATCTTCTGGAGATCACAGCTCTTCATTGATCAGCCACAGTTTCTTAAATTCAATATCTCT
CTTCAGAAGGATGCATTGATTGGAGTATATGGCCGGAAAGGCTTACCGCCTTCCCATACTCAGTATGACTTCGTGGAGCTCCTGGATGGCAGCAGGCTGA
TTGCCAGAGAGCAGCGGAGCCTGCTTGAGACGGAGAGAGCCGGGCGGCAGGCGAGATCCGTCAGCCTTCATGAGGCCGGCTTTATCCAGTACTTGGATTC
TGGAATCTGGCATCTGGCTTTTTATAATGATGGGAAAAATGCAGAGCAGGTGTCTTTTAATACCATTGTTATAGAGTCTGTGGTGGAATGTCCCCGAAAT
TGCCATGGAAATGGAGAATGCGTTTCTGGAACTTGCCATTGTTTTCCAGGATTTCTGGGTCCGGATTGTTCAAGAGCCGCCTGTCCAGTGTTATGTAGTG
GCAACGGGCAGTACTCCAAGGGCCGCTGCCTGTGTTTCAGCGGCTGGAAGGGCACCGAGTGTGATGTGCCGACTACCCAGTGTATTGACCCACAGTGTGG
GGGTCGTGGGATTTGTATCATGGGCTCTTGTGCTTGCAACTCAGGATACAAAGGAGAAAGTTGTGAAGAAGCTGACTGTATAGACCCTGGGTGTTCTAAT
CATGGTGTGTGTATCCACGGGGAATGTCACTGCAGTCCAGGATGGGGAGGTAGCAATTGTGAAATACTGAAGACCATGTGTCCAGACCAGTGCTCCGGCC
ACGGAACGTATCTTCAAGAAAGTGGCTCCTGCACGTGTGACCCTAACTGGACTGGCCCAGACTGCTCAAACGAAATATGTTCTGTGGACTGTGGCTCACA
CGGCGTTTGCATGGGGGGGACGTGTCGCTGTGAAGAAGGCTGGACGGGCCCAGCCTGTAATCAGAGAGCCTGCCACCCCCGCTGTGCCGAGCACGGGACC
TGCAAGGATGGCAAGTGTGAATGCAGCCAGGGCTGGAATGGAGAGCACTGCACTATCGCTCACTATTTGGATAAGATAGTTAAAGAGGGTTGTCCTGGTC
TGTGCAACAGCAATGGAAGATGTACCCTGGACCAAAATGGCTGGCATTGTGTGTGCCAGCCTGGATGGAGAGGAGCAGGCTGTGACGTAGCCATGGAGAC
TCTTTGCACAGATAGCAAGGACAATGAAGGAGATGGACTCATTGACTGCATGGATCCCGATTGCTGCCTACAGAGTTCCTGCCAGAATCAGCCCTATTGT
CGGGGACTGCCGGATCCTCAGGACATCATTAGCCAAAGCCTTCAATCGCCTTCTCAGCAAGCTGCCAAATCCTTTTATGATCGAATCAGTTTCCTTATAG
GATCTGATAGCACCCATGTTATACCTGGAGAAAGTCCTTTCAATAAGAGCCTTGCATCTGTCATCAGAGGCCAAGTACTGACTGCTGATGGAACTCCACT
TATTGGAGTAAATGTCTCGTTTTTCCATTACCCAGAATATGGATATACTATTACCCGCCAGGACGGAATGTTTGACTTGGTGGCAAATGGTGGGGCCTCT
CTAACTTTGGTATTTGAACGATCCCCATTCCTCACTCAGTATCATACTGTGTGGATTCCATGGAATGTCTTTTATGTGATGGATACCCTAGTCATGAAGA
AAGAAGAGAATGATATTCCCAGCTGTGATCTGAGTGGATTCGTGAGGCCAAATCCCATCATTGTGTCATCACCTTTATCCACCTTTTTCAGATCTTCTCC
TGAAGACAGTCCCATCATTCCCGAAACACAGGTACTCCACGAGGAAACTACAATTCCAGGAACAGATTTGAAACTCTCCTACTTGAGTTCCAGAGCTGCA
GGGTATAAGTCAGTTCTCAAGATCACCATGACCCAGTCTATTATTCCATTTAATTTAATGAAGGTTCATCTTATGGTAGCTGTAGTAGGAAGACTCTTCC
AAAAGTGGTTTCCTGCCTCACCAAACTTGGCCTATACTTTCATATGGGATAAAACAGATGCATATAATCAGAAAGTCTATGGTCTATCTGAAGCTGTTGT
GTCAGTTGGATATGAGTATGAGTCGTGTTTGGACCTGACTCTGTGGGAAAAGAGGACTGCCATTCTGCAGGGCTATGAATTGGATGCGTCCAACATGGGT
GGCTGGACATTAGATAAACATCACGTGCTGGATGTACAGAACGGTATACTGTACAAGGGAAACGGGGAAAACCAGTTCATCTCCCAGCAGCCTCCAGTCG
TGAGTAGCATCATGGGCAATGGGCGAAGGCGCAGCATTTCCTGCCCCAGTTGCAATGGTCAAGCTGATGGTAACAAGTTACTGGCCCCAGTGGCGCTAGC
TTGTGGGATCGATGGCAGTCTGTACGTAGGCGATTTCAACTATGTGCGGCGGATATTCCCTTCTGGAAATGTAACAAGTGTCTTAGAACTAAGAAATAAA
GATTTTAGACATAG
CAGCAACCCAGCTCATAGATACTACCTTGCAACGGATCCAGTCACGGGAGATCTGTACGTTTCTGACACAAACACCCGCAGAATTT
ATCGCCCAAAGTCACTTACGGGGGCAAAAGACTTGACTAAAAATGCAGAAGTCGTCGCAGGGACAGGGGAGCAATGCCTTCCGTTTGACGAGGCGAGATG
TGGGGATGGAGGGAAGGCCGTGGAAGCCACACTCATGAGTCCCAAAGGAATGGCAGTTGATAAGAATGGATTAATCTACTTTGTTGATGGAACCATGATT
AGGAAAGTTGACCAAAATGGAATCATATCAACTCTTCTGGGCTCTAACGATTTGACTTCAGCCAGACCTTTAACTTGTGACACCAGCATGCACATCAGCC
AGGTACGTCTGGAATGGCCCACTGACCTAGCCATTAACCCTATGGATAACTCCATTTATGTCCTGGATAATAATGTAGTTTTACAGATCACTGAAAATCG
TCAAGTTCGCATTGCTGCTGGACGGCCCATGCACTGTCAGGTTCCCGGAGTGGAATATCCTGTGGGGAAGCACGCGGTGCAGACAACACTGGAATCAGCC
ACTGCCATTGCTGTGTCCTACAGTGGGGTCCTGTACATTACTGAAACTGATGAGAAGAAAATTAACCGGATAAGGCAGGTCACAACAGATGGAGAAATCT
CCTTAGTGGCCGGAATACCTTCAGAGTGTGACTGCAAAAATGATGCCAACTGTGACTGTTACCAGAGTGGAGATGGCTACGCCAAGGATGCCAAACTCAG
TGCCCCATCCTCCCTGGCTGCTTCTCCAGATGGTACACTGTATATTGCAGATCTAGGGAATATCCGGATCCGGGCTGTGTCAAAGAATAAGCCTTTACTT
AACTCTATGAACTTCTATGAAGTTGCGTCTCCAACTGATCAAGAACTCTACATCTTTGACATCAATGGTACTCACCAATATACTGTAAGTTTAGTCACTG
GTGATTACCTTTACAATTTTAGCTACAGCAATGACAATGATATTACTGCTGTGACAGACAGCAATGGCAACACCCTTAGAATTAGACGGGACCCAAATCG
CATGCCAGTTCGAGTGGTGTCTCCTGATAACCAAGTGATATGGTTGACAATAGGAACAAATGGATGTTTGAAAAGCATGACTGCTCAAGGACTGGAATTA
GTTTTGTTTACTTACCATGGCAATAGTGGCCTTTTAGCCACTAAAAGTGATGAAACTGGATGGACAACGTTTTTTGACTATGACAGTGAAGGTCGTCTGA
CAAATGTTACGTTTCCAACTGGAGTGGTCACAAACCTGCATGGGGACATGGACAAGGCTATCACAGTGGACATTGAGTCATCTAGCCGAGAAGAAGATGT
CAGCATCACTTCAAATCTGTCCTCGATCGATTCTTTCTACACCATGGTTCAAGATCAGTTAAGAAACAGCTACCAGATTGGTTATGACGGCTCCCTCAGA
ATTATCTACGCCAGTGGCCTGGACTCACACTACCAAACAGAGCCGCACGTTCTGGCTGGCACCGCTAATCCGACGGTTGCCAAAAGAAACATGACTTTGC
CTGGCGAGAACGGTCAAAACTTGGTGGAATGGAGATTCCGAAAAGAGCAAGCCCAAGGGAAAGTCAATGTCTTTGGCCGCAAGCTCAGGGTTAATGGCAG
AAACCTCCTTTCAGTTGACTTTGATCGAACAACAAAGACAGAAAAGATCTATGACGACCACCGTAAATTTCTACTGAGGATCGCCTACGACACGTCTGGG
CACCCGACTCTCTGGCTGCCAAGCAGCAAGCTGATGGCCGTCAATGTCACCTATTCATCCACAGGTCAAATTGCCAGCATCCAGCGAGGCACCACTAGCG
AGAAAGTAGATTATGACGGACAGGGGAGGATCGTGTCTCGGGTCTTTGCTGATGGTAAAACATGGAGTTACACATATTTAGAAAAGTCCATGGTTCTTCT
GCTTCATAGCCAGCGGCAGTACATCTTCGAATACGATATGTGGGACCGCCTGTCTGCCATCACCATGCCCAGTGTGGCTCGCCACACCATGCAGACCATC
CGATCCATTGGCTACTACCGCAACATATACAACCCCCCGGAAAGCAACGCCTCCATCATCACGGACTACAACGAGGAAGGGCTGCTTCTACAAACAGCTT
TCTTGGGTACAAGTCGGAGGGTCTTATTCAAATACAGAAGGCAGACTAGGCTCTCAGAAATTTTATATGATAGCACAAGAGTCAGTTTTACCTATGATGA
AACAGCAGGAGTCCTAAAGACAGTAAACCTCCAGAGTGATGGTTTTATTTGCACCATTAGATACAGGCAAATTGGTCCCCTGATTGACAGGCAGATTTTC
CGCTTTAGTGAAGATGGGATGGTAAATGCAAGATTTGACTATAGCTATGACAACAGCTTTCGAGTGACCAGCATGCAGGGTGTGATCAATGAAACGCCAC
TGCCTATTGATCTGTATCAGTTTGATGACATTTCTGGCAAAGTTGAGCAGTTTGGAAAGTTTGGAGTTATATATTATGATATTAACCAGATCATTTCTAC
AGCTGTAATGACCTATACGAAGCACTTTGATGCTCATGGCCGTATCAAGGAGATTCAATATGAGATATTCAGGTCGCTCATGTACTGGATTACAATTCAG
TATGATAACATGGGTCGGGTAACCAAGAGAGAGATTAAAATAGGGCCCTTTGCCAACACCACCAAATATGCTTATGAATATGATGTTGATGGACAGCTCC
AAACAGTTTACCTCAATGAAAAGATAATGTGGCGGTACAACTACGATCTGAATGGAAACCTCCATTTACTGAACCCAAGTAACAGTGCGCGTCTGACACC
CCTTCGCTATGACCTGCGAGACAGAATCACTCGACTGGGTGATGTTCAATATCGGTTGGATGAAGATGGTTTCCTACGTCAAAGGGGCACGGAAATCTTT
GAATATAGCTCCAAGGGGCTTCTAACTCGAGTTTACAGTAAAGGCAGTGGCTGGACAGTGATCTACCGTTATGACGGCCTGGGAAGGCGTGTTTCTAGCA
AAACCAGTCTAGGACAGCACCTGCAGTTTTTTTATGCTGACTTAACTTATCCCACTAGGATTACTCATGTCTACAACCATTCGAGTTCAGAAATTACCTC
CCTGTATTATGATCTCCAAGGACATCTTTTTGCCATGGAAATCAGCAGTGGGGATGAATTCTATATTGCATCGGATAACACAGGGACACCACTGGCTGTG
TTCAGTAGCAATGGGCTTATGCTGAAACAGATTCAGTACACTGCATATGGGGAAATCTATTTTGACTCTAATATTGACTTTCAACTGGTAATTGGATTTC
ATGGTGGCCTGTATGACCCACTCACCAAATTAATCCACTTTGGAGAAAGAGATTATGACATTTTGGCAGGACGGTGGACAACACCTGACATAGAAATCTG
GAAAAGAATTGGGAAGGACCCAGCTCCTTTTAACTTGTACATGTTTAGGAATAACAACCCTGCAAGCAAAATCCATGACGTGAAAGATTACATCACAGAT
GTTAACAGCTGGCTGGTGACATTTGGTTTCCATCTGCACAATGCTATTCCTGGATTCCCTGTTCCCAAATTTGATTTAACAGAACCTTCTTACGAACTTG
TGAAGAGTCAGCAGTGGGATGATATACCGCCCATCTTCGGAGTCCAGCAGCAAGTGGCGCGGCAGGCCAAGGCCTTCCTGTCGCTGGGGAAGATGGCCGA
GGTGCAGGTGAGCCGGCGCCGGGCCGGCGGCGCGCAGTCCTGGCTGTGGTTCGCCACGGTCAAGTCGCTGATCGGCAAGGGCGTCATGCTGGCCGTCAGC
CAGGGCCGCGTGCAGACCAACGTGCTCAACATCGCCAACGAGGACTGCATCAAGGTGGCGGCCGTGCTCAACAACGCCTTCTACCTGGAGAACCTGCACT
TCACCATCGAGGGCAAGGACACGCACTACTTCATCAAGACCACCACGCCCGAGAGCGACCTGGGCACGCTGCGGTTGACCAGCGGCCGCAAGGCGCTGGA
GAACGGCATCAACGTGACGGTGTCGCAGTCCACCACGGTGGTGAACGGCAGGACGCGCAGGTTCGCGGACGTGGAGATGCAGTTCGGCGCGCTGGCGCTG
CACGTGCGCTACGGCATGACCCTGGACGAGGAGAAGGCGCGCATCCTGGAGCAGGCGCGGCAGCGCGCGCTCGCCCGGGCCTGGGCGCGCGAGCAGCAGC
GCGTGCGCGACGGCGAGGAGGGCGCGCGCCTCTGGACGGAGGGCGAGAAGCGGCAGCTGCTGAGCGCCGGCAAGGTGCAGGGCTACGACGGGTACTACGT
ACTCTCGGTGGAGCAGTACCCCGAGCTGGCCGACAGCGCCAACAACATCCAGTTCCTGCGGCAGAGCGAGATCGGCAGGAGGTAACGCCCGGGCCGCGCC
CGCCGAGCCGCTCACGCCCTGCCCACATTGTCCTGTGGCACAACCCGAGTGGGACTCTCCAACGCCCAAGAGCCTTCCTCCCGGGGGAATGAGACTGCTG
TTACGACCCACACCCACACCGCGAAAACAAGGACCGCTTTTTTCCGAATGACCTTAAAGGTGATCGGCTTTAACGAATATGTTTACATATGCATAGCGCT
GCACTCAGTCGGACTGAACGTAGCCAGAGGAAAAAAAAATCATCAAGGACAAAGGCCTCGACCTGTTGCGCTGGGCCGTCTGTTCCTTCTAGGCACTGTA
TTTAACTAACTTTAAAAAAGAAAAAAAAATGTGTACAGTGTTTCCAAATAGTCCCGAATTGTCGACCTTTGCTTACAAGAAGTAGTCTGTCTGCATAGGA
TGTGATAGCTATCTCTGTTCATTTTACAATGTGGGGCAAAGTTACTGTTTCTAGACAACCCAACTGCTTTCCCTGTGCAGCTTTGTAGAAGGACATTGGC
ACAGTGACTTCTGCGGCGGGGATTTATTAATGGATTTTACAATGCTAACGTGGTTTCCCTTCGGGGAAAAAACTGGCAACTAGAATCCTTGTCACTGATA
AGCAAAGGAAATCCTGATTTTTTTGTAAATTATGTGAGACAAGTTGTTTATGGATTTTTATATGAATTACAATTTACTGTACATCAAATCTTAGTCTCAG
AGGAGTTAATTTATGTAAAGTGTTTAAAAATTTATACTTAAAAATAAAATGATAAAAACGTGAACTGTGTGATTTTTTTAAAAGGATTGCACCTTTTGTT
ATCTGTTATAGCTGTACAGTATGAATTATTATATTGTAGAGATATAACAACTTATGCCTATAATGTCCAGAAGTGTTAATATTTTTGTATTAGGTTGAAA
AAATGTGCAAGCTTCTATCACTAGATGGATAGGACCGTGCAATTCTAGGTGGGTGGCGAATCAGAGAGCTCCTTTCTCTTCCCTCTCTCACGCATCAGGC
CAGTGTCCTCAGCATTGTCAACTGAGAGGCACAGTAGACAACTAGGGCTGGTGGAATGTAAGGGAAGAAGATTGAAAAAACGGGAGGAAGGGTTCTCTGG
CCCTCTCTCAACCTTGCAAGTCAATGGGGAGTTGTTGATATAATTAACCCCGAGGTTTTTACTGTTACTGTTCCAAAGCTCTGTCTCTTGATGGAGGAGA
GACCACATCAGATGCTGGGGAAATAGGAGGAGGAAAGGTTCTGATGTAGTCGTGATCCTAAACACGTGTCTTAAGATCTAGGAAAGACAGCAGAAACCGA
GCAGTGGTGGGTGAGCCAGATGGAGCCGGTCAGGGTTACTCTAAGCCCACATGACCAAACCATCTTGGGGGGCTGGTTTGAATGACAGCCTCTGCTCTGT
CTCGGGGAAGCCGGGGGTGGCAGATCCAGCTGGAAGTGAACTGACAGCCGCGCCCTCCTGCACACATGCATGCACGCGTGTGGGAACGAGCCCAGCCGCC
ATCTGCACTTCCGTGTCGGCTCAGCTCTGACAAATCTCTTTCCTGAGCACTAAATTCAGCCACGAAAATATTTTTAGAAGATATTTCTCAGTTCATCGAG
CTATAGTACACACTGTTTTCCTCTATGTATAATGGTGATAAAATATAGCAAGTGAACATGTCGTAAATATAAAGGTTCAAGTGATGTATTGAAAATAATT
TTCTAACTGCTTTGTATGTATCACATACTCTAAATTGCACAGTAGGCGTGTTTATTAAACAGATGATTGGCTGGGAAAGTTTCAAAATAGCTACTGAATT
TACAGTATCAGTGCTATTACTGTCTTTGTGTATTTGGTAGAGCATACCGAAGTAATTAATCTTCTAATGAATGCTGATGATATTTTATTAGAATGAAAGC
ACAGATTAGCATTAATATTTTTTATTCTGGAAATCCTTTGGCAAGTATTATGAAGCCCAAATTTAGAAAACTATGAGATTTCAAACCACATAAACATGAT
TCTGTTTTCCATTTTATTTTTTAACTGTTAGGTATTTGCAGTTCTGTTCCGTGGAACTTCTGCAGGCCTGTATTTAGCATGCTGTAAGTACTTTTGGGTG
AAATAGGCTCTGAGTCTAAATTCTCAGACATGTTTCTGATGTATTACCATGAAAAGCTTGTGCCACATGACAGAAGTGAGATCATAGTCTTAACCTCTTC
TTGACGTGGACTGGTCTTCACTCGGGCACCGATAAATAACAGATTTGGAGTATCTCCTGGTGCTTATTTTAGATGATGAAGTCAAATCAACCCAATTAGT
GTCCTGTTAGTAGGTATAATGAGCCTATTTCTTTCTAAAAAGACTTGTGATCTGGACATGCTTTTACAAGAAATAGTGACCTTGGGGAATATGTAAACAA
AAGACCTTTTTCTAAGAGTTGGGAGGGGGTGGGGGACTGTATAATGAAAAGAATTAGCTTACAAAAAAGAAATTGATATTCAAAGTATTTTAGGCAAAGC
CAGTCAAAATGCTTTCATGATATTTTGAGATGTAAATTTTGTCTGATTTGTATTGTTCTTTTCATTTGCCTTCTTAACTTTATATGTGACCTGAATTTTC
CATAACTTGATGACTATAGATTGCACCTAGGCATTCCAATAAAAGCCAACCCAATGTG
  • refseq_ODZ3.F1 (forward primer)
  • refseq_ODZ3.R1 (reverse primer)
  • Single exon skipping

Frame 0

TSRTDVHTEGMKYGCERTQALLLPDQEQTREGT
ALHKFLRRQ*GVPGTHTEVLQFQRDIESF*S*FL
AAALRQQSEGFGSQRSRRVH*TRTEFYPKAVRS
L*TSNSKRTGILCGNGAPSQRLLYQCRVRC*Y*
K*SSDVPRACHETLGQGGQIRPQLLPVKSVQLSP
HPDRYGARKQVRQ*E*ATCKQSRPVYPAALAAF
P*AALCTASSIHHFSQQKLPDQ*KEPESGPAGC
FARRAANHTRVRPAAGQLGPWQ*CTTGKQAFPIQ
NRNRYNATVQYCNPRIHNGIWLCLFTTYSATT*
KHPIKKCF*IQEVFKVL*LEMHCTVCRRGLGAP
GNTPVLFYSNASLWPQLAATAD*K*HI*EWKSEF
*YHANKHCVITFWRQWKIRWIYARK*HHRFRRT
*YWPKSNSRDSSRDLLEITALH*SATVS*IQYL
SSEGCIDWSIWPERLTAFPYSV*LRGAPGWQQAD
CQRAAEPA*DGESRAAGEIRQPS*GRLYPVLGF
WNLASGFL**WEKCRAGVF*YHCYRVCGGMSPK
LPWKWRMRFWNLPLFSRISGSGLFKSRLSSVM*W
QRAVLQGPLPVFQRLEGHRV*CADYPVY*PTVW
GSWDLYHGLLCLQLRIQRRKL*RS*LYRPWVF*
SWCVYPRGMSLQSRMGR*QL*NTEDHVSRPVLRP
RNVSSRKWLLHV*P*LDWPRLLKRNMFCGLWLT
RRLHGGDVSL*RRLDGPSL*SESLPPPLCRARD
LQGWQV*MQPGLEWRALHYRSLFG*DS*RGLSWS
VQQQWKMYPGPKWLALCVPAWMERSRL*RSHGD
SLHR*QGQ*RRWTH*LHGSRLLPTEFLPESALL
SGTAGSSGHH*PKPSIAFSASCQILL*SNQFPYR
I**HPCYTWRKSFQ*EPCICHQRPSTDC*WNST
YWSKCLVFPLPRIWIYYYPPGRNV*LGGKWWGL
SNFGI*TIPIPHSVSYCVDSMECLLCDGYPSHEE
RRE*YSQL*SEWIREAKSHHCVITFIHLFQIFS
*RQSHHSRNTGTPRGNYNSRNRFETLLLEFQSC
RV*VSSQDHHDPVYYSI*FNEGSSYGSCSRKTLP
KVVSCLTKLGLYFHMG*NRCI*SESLWSI*SCC
VSWI*V*VVFGPDSVGKEDCHSAGL*IGCVQHG
WLDIR*TSRAGCTERYTVQGKRGKPVHLPAASSR
E*HHGQWAKAQHFLPQLQWSS*W*QVTGPSGAS
LWDRWQSVRRRFQLCAADIPFWKCNKCLRTKK*
RF*T*
QQPSS*ILPCNGSSHGRSVRF*HKHPQNL
SPKVTYGGKRLD*KCRSRRRDRGAMPSV*RGEM
WGWREGRGSHTHESQRNGS**EWINLLC*WNHD
*ES*PKWNHINSSGL*RFDFSQTFNL*HQHAHQP
GTSGMAH*PSH*PYG*LHLCPG**CSFTDH*KS
SSSHCCWTAHALSGSRSGISCGEARGADNTGIS
HCHCCVLQWGPVHY*N**EEN*PDKAGHNRWRNL
LSGRNTFRV*LQK*CQL*LLPEWRWLRQGCQTQ
CPILPGCFSRWYTVYCRSREYPDPGCVKE*AFT
*LYELL*SCVSN*SRTLHL*HQWYSPIYCKFSHW
*LPLQF*LQQ*Q*YYCCDRQQWQHP*N*TGPKS
HASSSGVS**PSDMVDNRNKWMFEKHDCSRTGI
SFVYLPWQ*WPFSH*K**NWMDNVF*L*Q*RSSD
KCYVSNWSGHKPAWGHGQGYHSGH*VI*PRRRC
QHHFKSVLDRFFLHHGSRSVKKQLPDWL*RLPQ
NYLRQWPGLTLPNRAARSGWHR*SDGCQKKHDFA
WRERSKLGGMEIPKRASPRESQCLWPQAQG*WQ
KPPFS*L*SNNKDRKDL*RPP*ISTEDRLRHVW
APDSLAAKQQADGRQCHLFIHRSNCQHPARHH*R
ESRL*RTGEDRVSGLC*W*NMELHIFRKVHGSS
AS*PAAVHLRIRYVGPPVCHHHAQCGSPHHADH
PIHWLLPQHIQPPGKQRLHHHGLQRGRAASTNSF
LGYKSEGLIQIQKAD*ALRNFI**HKSQFYL**
NSRSPKDSKPPE*WFYLHH*IQANWSPD*QADF
PL**RWDGKCKI*L*L*QQLSSDQHAGCDQ*NAT
AY*SVSV**HFWQS*AVWKVWSYIL*Y*PDHFY
SCNDLYEAL*CSWPYQGDSI*DIQVAHVLDYNS
V**HGSGNQERD*NRALCQHHQICL*I*C*WTAP
NSLPQ*KDNVAVQLRSEWKPPFTEPK*QCASDT
PSL*PARQNHSTG*CSISVG*RWFPTSKGHGNL
*I*LQGASNSSLQ*RQWLDSDLPL*RPGKACF*Q
NQSRTAPAVFLC*LNLSH*DYSCLQPFEFRNYL
PVL*SPRTSFCHGNQQWG*ILYCIG*HRDTTGC
VQ*QWAYAETDSVHCIWGNLF*L*Y*LSTGNWIS
WWPV*PTHQINPLWRKRL*HFGRTVDNT*HRNL
EKNWEGPSSF*LVHV*E*QPCKQNP*RERLHHR
C*QLAGDIWFPSAQCYSWIPCSQI*FNRTFLRTC
EESAVG*YTAHLRSPAASGAAGQGLPVAGEDGR
GAGEPAPGRRRAVLAVVRHGQVADRQGRHAGRQ
PGPRADQRAQHRQRGLHQGGGRAQQRLLPGEPAL
HHRGQGHALLHQDHHARERPGHAAVDQRPQGAG
ERHQRDGVAVHHGGERQDAQVRGRGDAVRRAGA
ARALRHDPGRGEGAHPGAGAAARARPGLGARAAA
RARRRGGRAPLDGGREAAAAERRQGAGLRRVLR
TLGGAVPRAGRQRQQHPVPAAERDRQEVTPGPR
PPSRSRPAHIVLWHNPSGTLQRPRAFLPGE*DCC
YDPHPHRENKDRFFPNDLKGDRL*RICLHMHSA
ALSRTERSQRKKKSSRTKASTCCAGPSVPSRHC
I*LTLKKKKKCVQCFQIVPNCRPLLTRSSLSA*D
VIAISVHFTMWGKVTVSRQPNCFPCAAL*KDIG
TVTSAAGIY*WILQC*RGFPSGKKLATRILVTD
KQRKS*FFCKLCETSCLWIFI*ITIYCTSNLSLR
GVNLCKVFKNLYLKIK**KRELCDFFKRIAPFV
ICYSCTV*IIIL*RYNNLCL*CPEVLIFLY*VE
KMCKLLSLDG*DRAILGGWRIRELLSLPSLTHQA
SVLSIVN*EAQ*TTRAGGM*GKKIEKTGGRVLW
PSLNLASQWGVVDIINPEVFTVTVPKLCLLMEE
RPHQMLGK*EEERF*CSRDPKHVS*DLGKTAETE
QWWVSQMEPVRVTLSPHDQTILGGWFE*QPLLC
LGEAGGGRSSWK*TDSRALLHTCMHACGNEPSR
HLHFRVGSALTNLFPEH*IQPRKYF*KIFLSSSS
YSTHCFPLCIMVIKYSK*TCRKYKGSSDVLKII
F*LLCMYHIL*IAQ*ACLLNR*LAGKVSK*LLN
LQYQCYYCLCVFGRAYRSN*SSNEC**YFIRMKA
QISINIFYSGNPLASIMKPKFRKL*DFKPHKHD
SVFHFIF*LLGICSSVPWNFCRPVFSML*VLLG
EIGSESKFSDMFLMYYHEKLVPHDRSEIIVLTSS
*RGLVFTRAPINNRFGVSPGAYFR**SQINPIS
VLLVGIMSLFLSKKTCDLDMLLQEIVTLGNM*T
KDLFLRVGRGWGTV**KELAYKKEIDIQSILGKA
SQNAFMIF*DVNFV*FVLFFSFAFLTLYVT*IF
HNLMTIDCT*AFQ*KPTQC

Frame 1

PAGLMCTQKE*SMDVKERRPYCSLTKSRREKER
RYTNSSADNEECRVPTQKSYSSSETLKAFDHDS
SRLLYGNRVKDLVHREADEFTRQGQNFTLRQLGV
CEPATRRGLAFCAEMGLPHRGYSISAGSDADTE
NEAVMSPEHAMRLWGRGVKSGRSSCLSSRSNSA
LTLTDTEHENKSDSENEQPASNQGQSTLQPLPPS
HKQHSAQHHPSITSLNRNSLTNRRNQSPAPPAA
LPAELQTTPESVQLQDSWVLGSNVPLESRHFLF
KTGTGTTPLFSTATPGYTMASGSVYSPPTRPLPR
NTLSRSAFKFKKSSKYCSWKCTALCAVGVSVLL
AILLSYFIAMHLFGLNWQLQQTENDTFENGKVN
SDTMPTNTVSLPSGDNGKLGGFTQENNTIDSGEL
DIGRRAIQEIPPGIFWRSQLFIDQPQFLKFNIS
LQKDALIGVYGRKGLPPSHTQYDFVELLDGSRL
IAREQRSLLETERAGRQARSVSLHEAGFIQYLDS
GIWHLAFYNDGKNAEQVSFNTIVIESVVECPRN
CHGNGECVSGTCHCFPGFLGPDCSRAACPVLCS
GNGQYSKGRCLCFSGWKGTECDVPTTQCIDPQCG
GRGICIMGSCACNSGYKGESCEEADCIDPGCSN
HGVCIHGECHCSPGWGGSNCEILKTMCPDQCSG
HGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSH
GVCMGGTCRCEEGWTGPACNQRACHPRCAEHGT
CKDGKCECSQGWNGEHCTIAHYLDKIVKEGCPG
LCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMET
LCTDSKDNEGDGLIDCMDPDCCLQSSCQNQPYC
RGLPDPQDIISQSLQSPSQQAAKSFYDRISFLI
GSDSTHVIPGESPFNKSLASVIRGQVLTADGTPL
IGVNVSFFHYPEYGYTITRQDGMFDLVANGGAS
LTLVFERSPFLTQYHTVWIPWNVFYVMDTLVMK
KEENDIPSCDLSGFVRPNPIIVSSPLSTFFRSSP
EDSPIIPETQVLHEETTIPGTDLKLSYLSSRAA
GYKSVLKITMTQSIIPFNLMKVHLMVAVVGRLF
QKWFPASPNLAYTFIWDKTDAYNQKVYGLSEAVV
SVGYEYESCLDLTLWEKRTAILQGYELDASNMG
GWTLDKHHVLDVQNGILYKGNGENQFISQQPPV
VSSIMGNGRRRSISCPSCNGQADGNKLLAPVALA
CGIDGSLYVGDFNYVRRIFPSGNVTSVLELRNK
DFRHS
SNPAHRYYLATDPVTGDLYVSDTNTRRI
YRPKSLTGAKDLTKNAEVVAGTGEQCLPFDEARC
GDGGKAVEATLMSPKGMAVDKNGLIYFVDGTMI
RKVDQNGIISTLLGSNDLTSARPLTCDTSMHIS
QVRLEWPTDLAINPMDNSIYVLDNNVVLQITENR
QVRIAAGRPMHCQVPGVEYPVGKHAVQTTLESA
TAIAVSYSGVLYITETDEKKINRIRQVTTDGEI
SLVAGIPSECDCKNDANCDCYQSGDGYAKDAKLS
APSSLAASPDGTLYIADLGNIRIRAVSKNKPLL
NSMNFYEVASPTDQELYIFDINGTHQYTVSLVT
GDYLYNFSYSNDNDITAVTDSNGNTLRIRRDPNR
MPVRVVSPDNQVIWLTIGTNGCLKSMTAQGLEL
VLFTYHGNSGLLATKSDETGWTTFFDYDSEGRL
TNVTFPTGVVTNLHGDMDKAITVDIESSSREEDV
SITSNLSSIDSFYTMVQDQLRNSYQIGYDGSLR
IIYASGLDSHYQTEPHVLAGTANPTVAKRNMTL
PGENGQNLVEWRFRKEQAQGKVNVFGRKLRVNGR
NLLSVDFDRTTKTEKIYDDHRKFLLRIAYDTSG
HPTLWLPSSKLMAVNVTYSSTGQIASIQRGTTS
EKVDYDGQGRIVSRVFADGKTWSYTYLEKSMVLL
LHSQRQYIFEYDMWDRLSAITMPSVARHTMQTI
RSIGYYRNIYNPPESNASIITDYNEEGLLLQTA
FLGTSRRVLFKYRRQTRLSEILYDSTRVSFTYDE
TAGVLKTVNLQSDGFICTIRYRQIGPLIDRQIF
RFSEDGMVNARFDYSYDNSFRVTSMQGVINETP
LPIDLYQFDDISGKVEQFGKFGVIYYDINQIIST
AVMTYTKHFDAHGRIKEIQYEIFRSLMYWITIQ
YDNMGRVTKREIKIGPFANTTKYAYEYDVDGQL
QTVYLNEKIMWRYNYDLNGNLHLLNPSNSARLTP
LRYDLRDRITRLGDVQYRLDEDGFLRQRGTEIF
EYSSKGLLTRVYSKGSGWTVIYRYDGLGRRVSS
KTSLGQHLQFFYADLTYPTRITHVYNHSSSEITS
LYYDLQGHLFAMEISSGDEFYIASDNTGTPLAV
FSSNGLMLKQIQYTAYGEIYFDSNIDFQLVIGF
HGGLYDPLTKLIHFGERDYDILAGRWTTPDIEIW
KRIGKDPAPFNLYMFRNNNPASKIHDVKDYITD
VNSWLVTFGFHLHNAIPGFPVPKFDLTEPSYEL
VKSQQWDDIPPIFGVQQQVARQAKAFLSLGKMAE
VQVSRRRAGGAQSWLWFATVKSLIGKGVMLAVS
QGRVQTNVLNIANEDCIKVAAVLNNAFYLENLH
FTIEGKDTHYFIKTTTPESDLGTLRLTSGRKALE
NGINVTVSQSTTVVNGRTRRFADVEMQFGALAL
HVRYGMTLDEEKARILEQARQRALARAWAREQQ
RVRDGEEGARLWTEGEKRQLLSAGKVQGYDGYYV
LSVEQYPELADSANNIQFLRQSEIGRR*RPGRA
RRAAHALPTLSCGTTRVGLSNAQEPSSRGNETA
VTTHTHTAKTRTAFFRMTLKVIGFNEYVYICIAL
HSVGLNVARGKKNHQGQRPRPVALGRLFLLGTV
FN*L*KRKKNVYSVSK*SRIVDLCLQEVVCLHR
M**LSLFILQCGAKLLFLDNPTAFPVQLCRRTLA
Q*LLRRGFINGFYNANVVSLRGKNWQLESLSLI
SKGNPDFFVNYVRQVVYGFLYELQFTVHQILVS
EELIYVKCLKIYT*K*NDKNVNCVIFLKGLHLLL
SVIAVQYELLYCRDITTYAYNVQKC*YFCIRLK
KCASFYH*MDRTVQF*VGGESESSFLFPLSRIR
PVSSALSTERHSRQLGLVECKGRRLKKREEGFSG
PLSTLQVNGELLI*LTPRFLLLLFQSSVS*WRR
DHIRCWGNRRRKGSDVVVILNTCLKI*ERQQKP
SSGG*ARWSRSGLL*AHMTKPSWGAGLNDSLCSV
SGKPGVADPAGSELTAAPSCTHACTRVGTSPAA
ICTSVSAQL*QISFLSTKFSHENIFRRYFSVHR
AIVHTVFLYV*W**NIASEHVVNIKVQVMY*K*F
SNCFVCITYSKLHSRRVY*TDDWLGKFQNSY*I
YSISAITVFVYLVEHTEVINLLMNADDILLE*K
HRLALIFFILEILWQVL*SPNLENYEISNHINMI
LFSILFFNC*VFAVLFRGTSAGLYLACCKYFWV
K*ALSLNSQTCF*CITMKSLCHMTEVRS*S*PL
LDVDWSSLGHR*ITDLEYLLVLILDDEVKSTQLV
SC**V**AYFFLKRLVIWTCFYKK**PWGICKQ
KTFF*ELGGGGGLYNEKN*LTKKKLIFKVF*AK
PVKMLS*YFEM*ILSDLYCSFHLPS*LYM*PEFS
IT**L*IAPRHSNKSQPNV

Frame 2

QQD*CAHRRNEVWM*KNAGLTAP*PRADERRNG
ATQIPPQTMRSAGYPHRSPTVPARH*KLLIMIP
RGCFTATE*RIWFTEKQTSSLDKDRILP*GS*E
FVNQQLEEDWHFVRKWGSLTEVTLSVQGQMLILK
MKQ*CPQSMP*DFGAGGSNQAAAPACQVGPTQP
SP*QIRSTKTSPTVRMSNLQAIKASLPCSPCRL
PISSTLHSIIHPSLLSTETP*PIEGTRVRPRRLL
CPPSCKPHPSPSSCRTAGSLAVMYHWKAGISYS
KQEQVQRHCSVLQPQDTQWHLALFIHHLLGHYL
ETPYQEVLLNSRSLQSTVAGNALHCVP*GSRCSW
QYSCLIL*QCISLASTGSYSRLKMTHLRMEK*I
LIPCQQTLCHYLLETMEN*VDLRKKITP*IPEN
LILAEEQFKRFLPGSSGDHSSSLISHSFLNSISL
FRRMH*LEYMAGKAYRLPILSMTSWSSWMAAG*
LPESSGACLRRREPGGRRDPSAFMRPALSSTWI
LESGIWLFIMMGKMQSRCLLIPLL*SLWWNVPEI
AMEMENAFLELAIVFQDFWVRIVQEPPVQCYVV
ATGSTPRAAACVSAAGRAPSVMCRLPSVLTHSV
GVVGFVSWALVLATQDTKEKVVKKLTV*TLGVLI
MVCVSTGNVTAVQDGEVAIVKY*RPCVQTSAPA
TERIFKKVAPARVTLTGLAQTAQTKYVLWTVAH
TAFAWGGRVAVKKAGRAQPVIREPATPAVPSTGP
ARMASVNAARAGMESTALSLTIWIR*LKRVVLV
CATAMEDVPWTKMAGIVCASLDGEEQAVT*PWR
LFAQIARTMKEMDSLTAWIPIAAYRVPARISPIV
GDCRILRTSLAKAFNRLLSKLPNPFMIESVSL*
DLIAPMLYLEKVLSIRALHLSSEAKY*LLMELH
LLE*MSRFSITQNMDILLPARTECLTWWQMVGPL
*LWYLNDPHSSLSIILCGFHGMSFM*WIP*S*R
KKRMIFPAVI*VDS*GQIPSLCHHLYPPFSDLL
LKTVPSFPKHRYSTRKLQFQEQI*NSPT*VPELQ
GISQFSRSP*PSLLFHLI**RFILW*L**EDSS
KSGFLPHQTWPILSYGIKQMHIIRKSMVYLKLL
CQLDMSMSRVWT*LCGKRGLPFCRAMNWMRPTWV
AGH*INITCWMYRTVYCTRETGKTSSSPSSLQS
*VASWAMGEGAAFPAPVAMVKLMVTSYWPQWR*
LVGSMAVCT*AISTMCGGYSLLEM*QVS*N*EIK
ILDI
AATQLIDTTLQRIQSREICTFLTQTPAEF
IAQSHLRGQKT*LKMQKSSQGQGSNAFRLTRRD
VGMEGRPWKPHS*VPKEWQLIRMD*STLLMEP*L
GKLTKMESYQLFWALTI*LQPDL*LVTPACTSA
RYVWNGPLT*PLTLWITPFMSWIIM*FYRSLKI
VKFALLLDGPCTVRFPEWNILWGSTRCRQHWNQP
LPLLCPTVGSCTLLKLMRRKLTG*GRSQQMEKS
P*WPEYLQSVTAKMMPTVTVTRVEMATPRMPNS
VPHPPWLLLQMVHCILQI*GISGSGLCQRISLYL
TL*TSMKLRLQLIKNSTSLTSMVLTNIL*V*SL
VITFTILATAMTMILLL*QTAMATPLELDGTQI
ACQFEWCLLITK*YG*Q*EQMDV*KA*LLKDWN*
FCLLTMAIVAF*PLKVMKLDGQRFLTMTVKVV*
QMLRFQLEWSQTCMGTWTRLSQWTLSHLAEKKM
SASLQICPRSILSTPWFKIS*ETATRLVMTAPSE
LSTPVAWTHTTKQSRTFWLAPLIRRLPKET*LC
LARTVKTWWNGDSEKSKPKGKSMSLAASSGLMA
ETSFQLTLIEQQRQKRSMTTTVNFY*GSPTTRLG
TRLSGCQAAS*WPSMSPIHPQVKLPASSEAPLA
RK*IMTDRGGSCLGSLLMVKHGVTHI*KSPWFF
CFIASGSTSSNTICGTACLPSPCPVWLATPCRPS
DPLATTATYTTPRKATPPSSRTTTRKGCFYKQL
SWVQVGGSYSNTEGRLGSQKFYMIAQESVLPMM
KQQES*RQ*TSRVMVLFAPLDTGKLVP*LTGRFS
ALVKMGW*MQDLTIAMTTAFE*PACRV*SMKRH
CLLICISLMTFLAKLSSLESLELYIMILTRSFL
QL**PIRSTLMLMAVSRRFNMRYSGRSCTGLQFS
MITWVG*PRERLK*GPLPTPPNMLMNMMLMDSS
KQFTSMKR*CGGTTTI*METSIY*TQVTVRV*H
PFAMTCETESLDWVMFNIGWMKMVSYVKGARKSL
NIAPRGF*LEFTVKAVAGQ*STVMTAWEGVFLA
KPV*DSTCSFFMLT*LIPLGLLMSTTIRVQKLP
PCIMISKDIFLPWKSAVGMNSILHRITQGHHWLC
SVAMGLC*NRFSTLHMGKSILTLILTFNW*LDF
MVACMTHSPN*STLEKEIMTFWQDGGQHLT*KS
GKELGRTQLLLTCTCLGITTLQAKSMT*KITSQM
LTAGW*HLVSICTMLFLDSLFPNLI*QNLLTNL
*RVSSGMIYRPSSESSSKWRGRPRPSCRWGRWP
RCR*AGAGPAARSPGCGSPRSSR*SARASCWPSA
RAACRPTCSTSPTRTASRWRPCSTTPSTWRTCT
SPSRARTRTTSSRPPRPRATWARCG*PAAARRW
RTAST*RCRSPPRW*TAGRAGSRTWRCSSARWRC
TCATA*PWTRRRRASWSRRGSARSPGPGRASSS
ACATARRARASGRRARSGSC*APARCRATTGTT
YSRWSSTPSWPTAPTTSSSCGRARSAGGNARAAP
AEPLTPCPHCPVAQPEWDSPTPKSLPPGGMRLL
LRPTPTPRKQGPLFSE*P*R*SALTNMFTYA*R
CTQSD*T*PEEKKIIKDKGLDLLRWAVCSF*ALY
LTNFKKEKKMCTVFPNSPELSTFAYKK*SVCIG
CDSYLCSFYNVGQSYCF*TTQLLSLCSFVEGHW
HSDFCGGDLLMDFTMLTWFPFGEKTGN*NPCH**
AKEILIFL*IM*DKLFMDFYMNYNLLYIKS*SQ
RS*FM*SV*KFILKNKMIKT*TV*FF*KDCTFC
YLL*LYSMNYYIVEI*QLMPIMSRSVNIFVLG*K
NVQASITRWIGPCNSRWVANQRAPFSSLSHASG
QCPQHCQLRGTVDN*GWWNVREED*KNGRKGSL
ALSQPCKSMGSC*YN*PRGFYCYCSKALSLDGGE
TTSDAGEIGGGKVLM*S*S*TRVLRSRKDSRNR
AVVGEPDGAGQGYSKPT*PNHLGGLV*MTASAL
SRGSRGWQIQLEVN*QPRPPAHMHARVWERAQPP
SALPCRLSSDKSLS*ALNSATKIFLEDISQFIE
L*YTLFSSMYNGDKI*QVNMS*I*RFK*CIENN
FLTALYVSHTLNCTVGVFIKQMIGWESFKIATEF
TVSVLLLSLCIW*SIPK*LIF**MLMIFY*NES
TD*H*YFLFWKSFGKYYEAQI*KTMRFQTT*T*
FCFPFYFLTVRYLQFCSVELLQACI*HAVSTFG*
NRL*V*ILRHVSDVLP*KACAT*QK*DHSLNLF
LTWTGLHSGTDK*QIWSISWCLF*MMKSNQPN*
CPVSRYNEPISF*KDL*SGHAFTRNSDLGEYVNK
RPFSKSWEGVGDCIMKRISLQKRN*YSKYFRQS
QSKCFHDILRCKFCLICIVLFICLLNFICDLNF
P*LDDYRLHLGIPIKANPM

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