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Sequences

Sequence NM_001037293

ACTCGGCTCCGGGAGAGGCGAGCAGCGCCGGTGAGCCCCGCAGCAGCGCACCCGGCCGCGGAGCCCCGCGATGGAGATGGCAGAGGCGGAATTGCACAAG GAAAGGCTGCAAGCCATAGCAGAAAAAAGAAAGAGGCAGACTGAAATAGAAGGCAAGCGACAACAGCTTGACGAGCAGATACTTCTGCTGCAGCATTCCA AGTCCAAAGTGCTTCGGGAGAAATGGCTGCTGCAGGGCATACCCGCTGGAACTGCCGAAGAGGAGGAAGCCAGGAGGCGGCAGTCTGAAGAGGATGAGTT CAGAGTCAAGCAACTTGAAGATAACATTCAGAGGCTGGAGCAAGAAATACAAACGCTAGAAAGTGAAGAGTCCCAGATATCTGCCAAAGAGCAAATCATC CTAGAGAAACTGAAGGAAACAGAAAAATCCTTCAAGGACTTTCAGAAGGGTTTCTCCAGTACGGATGGAGCTGTGTACGCCATGGAAATTAATGTGGAGA AAGACAAACAAACAGGAGAGACCAAGATTCTCTCTACATCTACCATTGGCCCAGAGGGGGTCCATCAGAAAGGAGTCAAAGTCTATGATGATGGTACCAA AGTAGTGTATGAGGTGCGCTCAGGAGGCACCGTAGTAGAAAATGGAGTGCACAAATTAAGCACAAAGGATGTAGAAGAGCTTATTCAGAAGGCTGGACAA TCAAGCTTAGGAGGAGGGCACGTGTCTGAAAGGACTGTGATTGCAGATGGGAGCCTCAGCCATCCCAAGGAACACATGCTCTGCAAAGAAGCTAAGTTAG AAATGGTACATAAGTCTAGGAAAGACCATTCTTCCGGGAACCCAGGGCAGCAGGCCCAAGCCCCCAGCGCTGCAGGGCCGGAGGCAAACTTGGATCAGCC CGTCACCATGATTTTTATGGGCTACCAAAATATCGAGGATGAAGAGGAGACGAAAAAGGTGCTAGGCTATGATGAAACCATCAAGGCTGAATTGGTCCTC ATTGATGAAGATGATGAGAAGTCATTGAGGGAGAAGACAGTGACGGACGTGTCCACTATTGACGGGAACGCGGCTGAGCTTGTGTCCGGGAGGCCGGTCT CAGACACCACAGAGCCCTCATCCCCAGAAGGGAAGGAAGAGAGCCTAGCTACAGAGCCAGCCCCAGGTACCCAAAAGAAAAAGCGCTGTCAATGCTGTGT TGTCATGTGACCACTTCTTTCTTCTCCTTTCTTCTGGGCAGCCTGTACTCTCCACCACTCACGTAGACCTCACTGTACCACTAACTGCAATACTGTGAAC TGGAAGCAAACACCTGCCTTGCCTTGCAGTTGAATTGCTTTGATCTCTCTCATTTTTTTTCCTTTTCCTCACCTGAGAGACAACGTGCATGTGTGTGCTT CATTCTCTCCAAGAACTTGCTTTTCCTCTAAACCTTTCCTTGTGTCTTCAAGAGTGAATCACTTCCTTCCTGCTCGATTGGAATGGACTCTTCGTATCAG CCAGTGATATGGTAGCCTTAACTCACTTGACTGGAATTGAACCCATTGGCACTGGGGGTTTCATTTTGTAGTGTGTTCCTGTAACGTAGTCACACACTGC CATGTCTCTGGTTTCTCACTTGCCTCCTTTGCTGTGGATCTTTGTTTTTATATCTTGTGTGGCAAAATGCTGTTGGCTCTAGCCGGTTGCTAGTGTAGCC AAAAGTGGACCTTACTTAGTCTGTCCGATCTAGGGTGATGCTTTTTGCTGCCTTACATAAGCTTCCAGATTACAGTATTGTGCATTCATGGCTTTCTTTC TGTTAAAACTGAAATGAAGTCAATGTAGAAGAACCCAGAGCTTGTCACAGCTGAAATGTAGGGACTGATTCCATAACCTGCCCATCAGCGGTTGTCTCTC TTTCTATGGTTTAACCGATGAACCCTTTATATAAGAAGCACCATTTTAAAATTTCTAAGGACATGAAACAAACATTGTTTGAAGCATCAGTAGCAATTGA TCTCCAAACTTAGGCAAATTCACAAGCCTTGTTTCTATTCTCTTAAAAAAATGTAAATTTTTATATTGTTTCTTTTTTCTGGATATTTTCTGGTCATGTT AATCTATTTTCAATGAGGAGATCATCTTGAGAAGTATCTTTGCAGTGACCATATTTCTAAAACAGTCTGTCCAACCTACAATGGTTGCCATGATGCTCCC ACTTCATCATGGATGGTGCTGTAATGCATTAACTGTTCATCTCCTCCCCAGTTGATTACAAAGCCTTGCATCCATACTCTTTTCTTTCTGGCCCCATGAG AAAGAGAATGTTTTAGGTAACTTCAACTTGTAGGTTTATCTGCCCTTCAAAAAAAAAAACTTTAAAAAACTTTTAAAAATTAAGAAAGACCTATCTTCTC AATGTTAAGCACTTAATTTCATAACAAATATTAAGTGGCACATAGCTGAGCTTCTTAGGGCATTGTTTTGTTTTTAGCTTCTGGAGATTCCAGAAGAGCA AAGAATATTTTTTATCTAGAACACAATGAACAGTTTTTGAAATACCTTCTCAGCACTCCCCCAAAGCAAAAAGCCACATATGTAGTAAAACCAAAGGGAA ACAATTTAATAAAATAACAATAGTATAGTAATGAAATAAAGATATAACATGATTACTGGTTTTAATAAGAGTTATCTTAACTTTAAGTTATTTGCCCATT TATAGCATTGTTATGAATTATTCATAAAATTATGTCCCACAGTATATAGTTTTGAAAAAACATATGATATACTACATCCAGTCTAACTTCTGTGGAAAGT AGATCAGAAAAAATAAGATAGTCTTGAGAGAATTTTATTATAGAAGCTGTCTAATTTGACCTATTTTGCTTGCTCAGTGCTAAATCTATTGCTTTTTTTT AATCTCCTGGCTTGAAATTATATTTACTTCAATAGGAAAGGTAAAAACATCAGTTTTTACTTTTCAAAGTTAATTTTCTGAAATAATTGCATTTTAATGA GCACAAAATGGGTCATTTTATTTTTATTATACTCATCTTGTTTACACCTATACATAAACAGAAAACGTTAAAGAAGAGAAAAATAAAGGAGCTAAGTTCT GCTGTTGAAGATTATTTCATCCAAGGCTTGGTTTTGAATAACTGAGGGAAATATCTCTAAATCTCAAGTTCATCAAAGCAGCTGCAATGGAATAAAATTG CTATTTTATCGAGAAACCTGGTTTGGATGCTTATAAATTCCACTACTCTCAGCTTCATTTTCCTGAGTACGTGGTCACTGAAGCATCATTTAGACATTAC ATAAACTGGCATGCAGATAAACCTATTTACATAGAGGGAGAAAACAGTTTCAATGTCTTGGACAATCTGTTATTTTAATGATTTACTTAAGAAAGAAACA ATCTGAAAGCTTACCATAGCTTATCTTTTCTACTCACTTGGAGATTCAAGCTATTCAATGTGAGTTTTAAAAAGTTAAGCACAGTTAGTGAGTGAAATGG TAGAATGTAGAACCTTTAAGCTTGCTGGTTGATAAACAGAATCAATCTTCCAGGACAGATAATTCCCTGAAGGGACCTATCCTTGCATAAGTGAACTAGT TACTCATACAGAAAATGATCTGCACATCTTACTACAACACTACACACAAGAACTAAAAGATTAATGATTATCTGTATTCTCTTCACTAATTACTATTATG GGGGAATAATGATTAGCAAATTATATGAATTCGAGTTCTCTCTATACTTTTATTAGTAAAGCTTATCATTTAATGGACTGAAGTAAGATGTGTTACCTTT ATTCGAGCTATTTGTAGCCACACTAAATGAAGGTGTGTTTGAATATGGCGCATATATTTGCATATGTCCCATCATTTTCTTGTCATAATGGGGAATTCAG GCTTAGCCAGTACTTCTATGGGATGAGACCTATAATCCCACCTATAGCAGCAAGTAACTACCCTTCATGATGATAGTGTACATGGAGCTGTGATTATGAA CATGCTGCCTTTCCTGCTGCCATTGGCATTCTCTCTGTAAATTTTATTATGTGTGGTATCACACTCTCCAAAAATGCAGGGTATTTGGTTACATAACCAA ACTAATTAAAGAATCAGTAATGAAATTGCAAAACCATGATCTTTTTTGAGCTAATGATTAGTTGGGCTTTCCTTTAAAATAATATAATCAGGCCGAGTGC AGCGGCTCACACCTGTAATCTCGGCACTTTGGAAGTCCGCGGCGGGTGGTTCACCTGAGGTCGGGAGTTCAAGACCAGCCTGACCAACATGGAGAAACCC CCATCTCTACTAAAAAAAAAATACAAAATTAGCCAGGCGTGATGGCGCATGCCTGTAATCCCAGCTACTCGGGAGACTGAGGCAGGAGAATCGCTTGAAC CTGGGAGGCAGGGGTTGCAATGAGCCGAGATGTGCACTCCAGCCTGGGCAACAAAGAGCGAAACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAATCA TATAATCAGTTCCCTTTTAAATAGAAAGAGGAGGAAAAAAAAAAGGAAAAGGGGGGGTATCTCATTTGTATACAAATAGATTTTCAATGGCATTTAATAA AAGATTCTTTAATGGTTAAAATGATAAAGATTAATTCTACATATCTTGAAAAATCTTAATGACTTCTGTATTCTTGACTTCTTAAAAATATTTTCTTTCT TTTAGTGTGCAATAAGACAAACTAAGGGGAATTTTTTCAGCTTGTATCTCTTTTACCCATATTATTTTCCTTGCATAAGCAAAAAAATAATAATTGCCTC TAAAACTGATTTGACAGTGTTCAGTGACATCATTTAATATTGGTGATGGGGTGGAAGAGAAGGTAGGGAATGCCCTTATGGCCAAACCTAAAACACAGTT TCCTTGAGCCTTCTGAGCAATCTTAGAATTATTCAGAAGCTTTCAGGAAACTCAAATTCTATTAATTTGATTTGGTTCCTTTCCAAAATGTTAATAGACA TGTATTTGCTTAAAACGTCTACCTATTCCATTTAATTTCCTGCTGATAAATGTATTTTATCTACAAGCAAGTAGAATATTTTGTTTTGGTTAAAGTCAAG TTTTTATAAAAGGAGGGGAAGTATAAGAGAGAGTTTCCTAGAGATACAATATCATCTCTGGAGCAAAATGTTGAGGCCAAGTGTAAAAACAGACTATTTC TCTTTACTTCCTGCAGAATTTCATTTCAAGGGACCACAGCACACCCTTGAAAATTACCATTTATTTAATGCCAGTTGAACCAATGGGTAGCAAAAGAGGA GGGAGGGAACATGGTCATAGAGACAAAATCTAACTACTATACCAGGTCTTCCTTTGTAAGAAATATTAGCCCTGCCAATATAAAACGCAGATGGACATAG ACAGAATAAGCATCGAGGACTTTTTCTTATTTACTTGAAATCTAGAAGCTCAGTCATCTCTGCTCATCCCTGGACCCACTGGAGAGTTTTACTCACTAAC AGGTCCTTTCCTGGAAGAAATAACCTCATCTCCTGCCATATTAGTTTACAATAAAAATCATTCCAAAGTGAGCCATTTCACATTGCATTTTTGCCACATG CACATTTGCTATTGAAACCACAGATTCTCAGCATAAGTAAGACATAGGTGTTTCAGAAACTTCATAAATACACGATCTTTCAGGTGCTCCTCAATTTCTT AATCAAGGTATATTGAACTCCAGTGATTAGGATAGAACCTGAAAACATCCTTTGTTCTATTGGATAGTACAACACAGCAAGAGCACACAGTTATTTGTAT AATAAAACAACTTAATTAATGAGGAAGATGGGATGTTTGATTCCTGCTACCACCAGTTCACTTCACAAAGGCCTTCTTCTGGTATTACCAGGAAAACTTT CCTGCATTTTCTAGGGAAAAAGAAAAGTCGTTTATTAGGAGCACAATGCAGATATGTATCTGTGTTTTCATAGCTTCAGCAAACTTCTTAGTAAAATTCC CATTTCAACAAAAACCAAAATACTGATTGTTTGAATGTAGAAAGGTATAGAATAAAGACTACAAAGGGGAATTTTACCAGGGCTCCTTAGACCAGCTTCC CCAGCATAATTTTTATATAACTCAAGTAAGCCTCTGCTTCCCCTCTCCTTTCCAGTATAATATAAGAAGGTCGGAACTGTCGCACAAAAGAACTTGATTT CAATATGAAAATATAATATGTAATTTTGGGGACTGCAGACTTTCTGCATCAAAGATCTGGACAGCCTTAACTTTTATAAAAATAATTTTTCAATGTTCTC TTTTACTAACCAGGAAAACAAGATGTTTTCTGAAATTAATGACTTTTTCTATTTTGGGTCTGTTTTCTAAGTTTTTACAGGTTGAGGTATAAAGGGTCGT CTTCTCCTCATATTGCCTCTTCATAATCACCTGGGGCTATTTTTTGCAAGTCACTGCATTTTTACAAAAAATAAAAATAAAAAGTACATCTCACAAATCA TAAAATTCTCCCTAGACTTCAGACAGTCCTTCTGGAGTGAAAGAATAGAAATACAGAAAGAAAAGAATTACAGGGTGGCTTTCTTTTTATTTTCCTATGG TTAATGTACTGTATGGTATATATGTTTACAGAATGTATCTGCCTTGTGATGTTAACAAAATGAATGACAAAAAATAGTACTGATGTGCCATTTGACAGTT TGCCTTAGCATCACTGTTTATGTTCTTCTTTTCTGTCCTTTTTGGTAAAAAAAAACGCAGGTTGTATTCCAAAGCTGTATTAACACAACATTCTCTTCCC CACTCCTACCCAGCCTTCTTCAGAGCTGTGAATTTCATTACAGGAGCATTGAGGCAGAACCTTGCAGGTGTGGCCCAAAGGGGCTAAAGTGGGCATAGGT TGGGATTTACTTCTGCCCGTCTACCAACCAAACACGTATCTGTGTTCTCATATAAGCCTGCAAAATTTTACACCCTGCCTTTCAGGGAGACAGGCCACAT GGAGCGCATGACCTCTTGTAGTCGTCTCCTCACAGTCCTTCCCACTGTGAGAGAAGGAAACTTGCAGACCCCCAACTGGATCTGGGAGCATATTTTTAAG CACAGTTGGCATTGCTTGAAAAAGCAAGAGAGATGGACTCAAATTCTATGATTGAGCCATGACTGAGGAATGTGCCCATTCGTTATAGTCGAAGATGAGT AGGATGATATGGGTGAGAATAGGAGTGGCTGTAGAAATGGAATATTTTACAGTTATGTATTTTTTTAAGGAATAGTATTTTTATAATGAAATCTATATAC ATTATGGAGCTTGAGTTGGAAAACACCCTTGACTGAGCTATTTCTTCATTCCATTAAAGGTAACTTTCTGGGGAGTCCTATAGCACTAGGCCAAGCCTTG GGGGCATGAACAAAGGGCCTGTCACTTGGCCTTGCACTGCCATTACATGAGATCCAGTGTTTCCAAATAGGCCTTGGTTGGAAGATTGAGCTTTCTATAC CTGCCATTAGGTAGATTAGATAGATGGCTTGATAGCTCTCTGGGCTATACTTTTAATAATATATAATAATCTTTGGGAAGGAGATAGCTATTTTAAATGC AAGCAAAGCCCAGAAACTATCAAAGTCCAAATCTTTCACATATTTAAGGAGTAATTGCCACATTTGAGGTTAAGGGACCACTTACTATGGTGCATTTGAG AAATATATATGAAACGGTGAGTCAGAGCCCTCTGACCATCTTCAGTCTACACATAAGCAGATAAACCACCAATATAAATCTTATAGGGGCCAGACGAGGT GGCTTATGCCTGTAATCCCAGCACTTTGGGGGGCCAAGGCAGGAGGATAGTGTGAGCCCAGAAGTTCAAGACCAGGCTAGGCAACATGTTGAGACCATGT TGTTTAGTCTCTACTAAAAAATATAAAAATTAGCCAGCATGGTGGCACACACCTGTAGTCCCAGCTACTTGGGAGACTGAGGCAGGAGGATCACTTGAGC CCAGGAGGTGGAGGCTGCAGGGGGCTGAGATCTCACCACTCCATTCCAGCCTGGGCAACAGAGCAAGACTCTGTCTCAAAAAAAAAAACAAAAAAACAAT TATCAGTTGGCCTTCTACATAACACAGGGCTACACTGTATTTTTAGAGTTAAGTAGATACAGGAAAAGATTGTCTTTATCCATAAAGGAGATTCTGAATT TTTAGAGTTCCTGAATATTTTCCCCCAAGTTTCTGTCAAATTCCTGAAGTCCCTTCCCTATCACACTCAGTTTCCTGAAGCTCTTCCCCTACACCTGCTC CTCTGTCTGGCTAACAGAGTTGTCATGTCTCAGAAACTACTCACCACTCTTGTGAGACTCTCTTCCCAAGCATCATCCTTCCTCAGGATGAGGCCTTTTT CTACTACCCAAGAGATCAAGACCCTTTTTCTAACAAGACAAGGTTATATCTACTCCATTTTCAAGAGAAATAACCCCTCTGGTTCCCATGCAAATCGCTT AAATTCCTTCATCACCAGAATCTCTCCAACAGGCCCAACTCCAGCCCAGCTGTGAACACTGCTGTCATGGAGACAACTCCAAAATGAAAGAACTATGCAA TTGCCTGAAGGTGCTAATGGAGAGCCAGTTTACTCTAATCTCTTATTACTAAGGAACCTCTCGGTTTCGAGATTAAGTGGGCAGGGAGACATCCAGTCAC TTAGTTTTGCAATGACAGGTCTTGATATACACAGAGGCCACCAGGCAATGCCTGATCCAAACTATTCTGTATGTAGCTCCAACTCCAATTCTGTGATATC CTATTCTGGCAGGTGGGAAGAGTTCTATTCTTTGCAGGGTTCTGGAACATTCTTTCCTGCTCTCAAGCTCCTGACTTAGGAGAGTCAAAATCATACAGGG GTTCCAGAAAATGTTGTGTCTGATGCAGCTTCTCAGTGAATGTAGGTTGTTGGTGAAATTTTCAGCTTTAGCATCTCACTCGGGGTGAGTGATGTCTCTG TAAATACTTTCATTTGTGGTTGGTTGGTGGGGGTGGGGGTGGGAGCCTGTCGTGCTTACTCTGAATTAGCTTACTGGGCTAGCTGCTGTACTTTGTAACC TGAAGTGTACTTTGACTGTTCTGTTTCCTTCAGATGAAAAACAAAATAAAAACCGACTTCAGAAAAGACACTACCAGCGACAGCTGATGCTGTACTTGTA GCTTCTCTCTGTTCCTCTGTACAGTATTAATAGACAATAAACTGCCTTTTCACTGCATCTA

refseq_PALM2.F1 (forward primer)
refseq_PALM2.R1 (reverse primer)
Single exon skipping

Frame 0

TRLRERRAAPVSPAAAHPAAEPRDGDGRGGIAQ GKAASHSRKKKEAD*NRRQATTA*RADTSAAAFQ VQSASGEMAAAGHTRWNCRRGGSQEAAV*RG*V QSQAT*R*HSEAGARNTNARK*RVPDICQRANH PRETEGNRKILQGLSEGFLQYGWSCVRHGN*CGE RQTNRRDQDSLYIYHWPRGGPSERSQSL**WYQ SSV*GALRRHRSRKWSAQIKHKGCRRAYSEGWT IKLRRRARV*KDCDCRWEPQPSQGTHALQRS*VR NGT*V*ERPFFREPRAAGPSPQRCRAGGKLGSA RHHDFYGLPKYRG*RGDEKGARL**NHQG*IGP H**R**EVIEGEDSDGRVHY*RERG*ACVREAGL RHHRALIPRREGREPSYRASPRYPKEKALSMLC CHVTTSFFSFLLGSLYSPPLT*TSLYH*LQYCE LEANTCLALQLNCFDLSHFFSFSSPERQRACVCF ILSKNLLFL*TFPCVFKSESLPSCSIGMDSSYQ PVIW*P*LT*LELNPLALGVSFCSVFL*RSHTL PCLWFLTCLLCCGSLFLYLVWQNAVGSSRLLV*P KVDLT*SVRSRVMLFAALHKLPDYSIVHSWLSF C*N*NEVNVEEPRACHS*NVGTDSITCPSAVVS LSMV*PMNPLYKKHHFKISKDMKQTLFEASVAID LQT*ANSQALFLFS*KNVNFYIVSFFWIFSGHV NLFSMRRSS*EVSLQ*PYF*NSLSNLQWLP*CS HFIMDGAVMH*LFISSPVDYKALHPYSFLSGPMR KRMF*VTSTCRFICPSKKKTLKNF*KLRKTYLL NVKHLIS*QILSGT*LSFLGHCFVFSFWRFQKS KEYFLSRTQ*TVFEIPSQHSPKAKSHICSKTKGK QFNKITIV***NKDIT*LLVLIRVILTLSYLPI YSIVMNYS*NYVPQYIVLKKHMIYYIQSNFCGK *IRKNKIVLREFYYRSCLI*PILLAQC*IYCFFL ISWLEIIFTSIGKVKTSVFTFQS*FSEIIAF** AQNGSFYFYYTHLVYTYT*TENVKEEKNKGAKF CC*RLFHPRLGFE*LREISLNLKFIKAAAME*NC YFIEKPGLDAYKFHYSQLHFPEYVVTEASFRHY INWHADKPIYIEGENSFNVLDNLLF**FT*ERN NLKAYHSLSFLLTWRFKLFNVSFKKLSTVSE*NG RM*NL*ACWLINRINLPGQIIP*RDLSLHK*TS YSYRK*SAHLTTTLHTRTKRLMIICILFTNYYY GGIMISKLYEFEFSLYFY**SLSFNGLK*DVLPL FELFVATLNEGVFEYGAYICICPIIFLS*WGIQ A*PVLLWDETYNPTYSSK*LPFMMIVYMEL*L* TCCLSCCHWHSLCKFYYVWYHTLQKCRVFGYITK LIKESVMKLQNHDLF*AND*LGFPLK*YNQAEC SGSHL*SRHFGSPRRVVHLRSGVQDQPDQHGET PISTKKKIQN*PGVMAHACNPSYSGD*GRRIA*T WEAGVAMSRDVHSSLGNKERNSISKKKKKKKKS YNQFPFK*KEEEKKKEKGGYLICIQIDFQWHLI KDSLMVKMIKINSTYLEKS**LLYS*LLKNIFFL LVCNKTN*GEFFQLVSLLPILFSLHKQKNNNCL *N*FDSVQ*HHLILVMGWKRR*GMPLWPNLKHS FLEPSEQS*NYSEAFRKLKFY*FDLVPFQNVNRH VFA*NVYLFHLISC**MYFIYKQVEYFVLVKVK FL*KEGKYKREFPRDTISSLEQNVEAKCKNRLF LFTSCRISFQGTTAHP*KLPFI*CQLNQWVAKEE GGNMVIETKSNYYTRSSFVRNISPANIKRRWT* TE*ASRTFSYLLEI*KLSHLCSSLDPLESFTH* QVLSWKK*PHLLPY*FTIKIIPK*AISHCIFATC TFAIETTDSQHK*DIGVSETS*IHDLSGAPQFL NQGILNSSD*DRT*KHPLFYWIVQHSKSTQLFV **NNLINEEDGMFDSCYHQFTSQRPSSGITRKTF LHFLGKKKSRLLGAQCRYVSVFS*LQQTS**NS HFNKNQNTDCLNVERYRIKTTKGNFTRAP*TSF PSIIFI*LK*ASASPLLSSII*EGRNCRTKELDF NMKI*YVILGTADFLHQRSGQP*LL*K*FFNVL FY*PGKQDVF*N**LFLFWVCFLSFYRLRYKGS SSPHIASS*SPGAIFCKSLHFYKK*K*KVHLTNH KILPRLQTVLLE*KNRNTERKELQGGFLFIFLW LMYCMVYMFTECICLVMLTK*MTKNSTDVPFDS LP*HHCLCSSFLSFLVKKNAGCIPKLY*HNILFP TPTQPSSEL*ISLQEH*GRTLQVWPKGAKVGIG WDLLLPVYQPNTYLCSHISLQNFTPCLSGRQAT WSA*PLVVVSSQSFPL*EKETCRPPTGSGSIFLS TVGIA*KSKRDGLKFYD*AMTEECAHSL*SKMS RMIWVRIGVAVEMEYFTVMYFFKE*YFYNEIYI HYGA*VGKHP*LSYFFIPLKVTFWGVL*H*AKPW GHEQRACHLALHCHYMRSSVSK*ALVGRLSFLY LPLGRLDRWLDSSLGYTFNNI**SLGRR*LF*M QAKPRNYQSPNLSHI*GVIATFEVKGPLTMVHLR NIYETVSQSPLTIFSLHISR*TTNINLIGARRG GLCL*SQHFGGPRQEDSVSPEVQDQARQHVETM LFSLY*KI*KLASMVAHTCSPSYLGD*GRRIT*A QEVEAAGG*DLTTPFQPGQQSKTLSQKKKQKNN YQLAFYITQGYTVFLELSRYRKRLSLSIKEILN F*SS*IFSPKFLSNS*SPFPITLSFLKLFPYTCS SVWLTELSCLRNYSPLL*DSLPKHHPSSG*GLF LLPKRSRPFF*QDKVISTPFSREITPLVPMQIA *IPSSPESLQQAQLQPSCEHCCHGDNSKMKELCN CLKVLMESQFTLISYY*GTSRFRD*VGRETSSH LVLQ*QVLIYTEATRQCLIQTILYVAPTPIL*Y PILAGGKSSILCRVLEHSFLLSSS*LRRVKIIQG FQKMLCLMQLLSECRLLVKFSALASHSG*VMSL *ILSFVVGWWGWGWEPVVLTLN*LTGLAAVLCN LKCTLTVLFPSDEKQNKNRLQKRHYQRQLMLYL* LLSVPLYSINRQ*TAFSLHL

Frame 1

LGSGRGEQRR*APQQRTRPRSPAMEMAEAELHK ERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHS KSKVLREKWLLQGIPAGTAEEEEARRRQSEEDEF RVKQLEDNIQRLEQEIQTLESEESQISAKEQII LEKLKETEKSFKDFQKGFSSTDGAVYAMEINVE KDKQTGETKILSTSTIGPEGVHQKGVKVYDDGTK VVYEVRSGGTVVENGVHKLSTKDVEELIQKAGQ SSLGGGHVSERTVIADGSLSHPKEHMLCKEAKL EMVHKSRKDHSSGNPGQQAQAPSAAGPEANLDQP VTMIFMGYQNIEDEEETKKVLGYDETIKAELVL IDEDDEKSLREKTVTDVSTIDGNAAELVSGRPV SDTTEPSSPEGKEESLATEPAPGTQKKKRCQCCV VM*PLLSSPFFWAACTLHHSRRPHCTTNCNTVN WKQTPALPCS*IALISLIFFPFPHLRDNVHVCA SFSPRTCFSSKPFLVSSRVNHFLPARLEWTLRIS Q*YGSLNSLDWN*THWHWGFHFVVCSCNVVTHC HVSGFSLASFAVDLCFYILCGKMLLALAGC*CS QKWTLLSLSDLG*CFLLPYISFQITVLCIHGFLS VKTEMKSM*KNPELVTAEM*GLIP*PAHQRLSL FLWFNR*TLYIRSTILKFLRT*NKHCLKHQ*QL ISKLRQIHKPCFYSLKKM*IFILFLFSGYFLVML IYFQ*GDHLEKYLCSDHISKTVCPTYNGCHDAP TSSWMVL*CINCSSPPQLITKPCIHTLFFLAP* ERECFR*LQLVGLSALQKKKL*KTFKN*ERPIFS MLST*FHNKY*VAHS*AS*GIVLFLASGDSRRA KNIFYLEHNEQFLKYLLSTPPKQKATYVVKPKG NNLIK*Q*YSNEIKI*HDYWF**ELS*L*VICPF IALL*IIHKIMSHSI*F*KNI*YTTSSLTSVES RSEKIR*S*ENFIIEAV*FDLFCLLSAKSIAFF *SPGLKLYLLQ*ER*KHQFLLFKVNFLK*LHFNE HKMGHFIFIILILFTPIHKQKTLKKRKIKELSS AVEDYFIQGLVLNN*GKYL*ISSSSKQLQWNKI AILSRNLVWMLINSTTLSFIFLSTWSLKHHLDIT *TGMQINLFT*REKTVSMSWTICYFNDLLKKET I*KLTIAYLFYSLGDSSYSM*VLKS*AQLVSEM VECRTFKLAG**TESIFQDR*FPEGTYPCISELV THTENDLHILLQHYTQELKD**LSVFSSLITIM GE**LANYMNSSSLYTFISKAYHLMD*SKMCYL YSSYL*PH*MKVCLNMAHIFAYVPSFSCHNGEFR LSQYFYGMRPIIPPIAASNYPS***CTWSCDYE HAAFPAAIGILSVNFIMCGITLSKNAGYLVT*P N*LKNQ**NCKTMIFFELMISWAFL*NNIIRPSA AAHTCNLGTLEVRGGWFT*GREFKTSLTNMEKP PSLLKKKYKISQA*WRMPVIPATRETEAGESLE PGRQGLQ*AEMCTPAWATKSETPSQKKKKKKKNH IISSLLNRKRRKKKRKRGGISFVYK*IFNGI** KIL*WLK**RLILHILKNLNDFCILDFLKIFSF F*CAIRQTKGNFFSLYLFYPYYFPCISKKIIIAS KTDLTVFSDII*YW*WGGREGRECPYGQT*NTV SLSLLSNLRIIQKLSGNSNSINLIWFLSKMLID MYLLKTSTYSI*FPADKCILSTSK*NILFWLKSS FYKRRGSIRESFLEIQYHLWSKMLRPSVKTDYF SLLPAEFHFKGPQHTLENYHLFNAS*TNG*QKR REGTWS*RQNLTTIPGLPL*EILALPI*NADGHR QNKHRGLFLIYLKSRSSVISAHPWTHWRVLLTN RSFPGRNNLISCHISLQ*KSFQSEPFHIAFLPH AHLLLKPQILSISKT*VFQKLHKYTIFQVLLNFL IKVY*TPVIRIEPENILCSIG*YNTARAHSYLY NKTT*LMRKMGCLIPATTSSLHKGLLLVLPGKL SCIF*GKRKVVY*EHNADMYLCFHSFSKLLSKIP ISTKTKILIV*M*KGIE*RLQRGILPGLLRPAS PA*FLYNSSKPLLPLSFPV*YKKVGTVAQKNLI SI*KYNM*FWGLQTFCIKDLDSLNFYKNNFSMFS FTNQENKMFSEINDFFYFGSVF*VFTG*GIKGR LLLILPLHNHLGLFFASHCIFTKNKNKKYISQI IKFSLDFRQSFWSERIEIQKEKNYRVAFFLFSYG *CTVWYICLQNVSAL*C*QNE*QKIVLMCHLTV CLSITVYVLLFCPFW*KKTQVVFQSCINTTFSS PLLPSLLQSCEFHYRSIEAEPCRCGPKGLKWA*V GIYFCPSTNQTRICVLI*ACKILHPAFQGDRPH GAHDLL*SSPHSPSHCERRKLADPQLDLGAYF* AQLALLEKAREMDSNSMIEP*LRNVPIRYSRR*V G*YG*E*EWL*KWNILQLCIFLRNSIFIMKSIY IMELELENTLD*AISSFH*R*LSGESYSTRPSL GGMNKGPVTWPCTAIT*DPVFPNRPWLED*AFYT CH*VD*IDGLIALWAILLIIYNNLWEGDSYFKC KQSPETIKVQIFHIFKE*LPHLRLRDHLLWCI* EIYMKR*VRAL*PSSVYT*ADKPPI*IL*GPDEV AYACNPSTLGGQGRRIV*AQKFKTRLGNMLRPC CLVSTKKYKN*PAWWHTPVVPATWETEAGGSLE PRRWRLQGAEISPLHSSLGNRARLCLKKKNKKTI ISWPST*HRATLYF*S*VDTGKDCLYP*RRF*I FRVPEYFPPSFCQIPEVPSLSHSVS*SSSPTPA PLSG*QSCHVSETTHHSCETLFPSIILPQDEAFF YYPRDQDPFSNKTRLYLLHFQEK*PLWFPCKSL KFLHHQNLSNRPNSSPAVNTAVMETTPK*KNYA IA*RC*WRASLL*SLITKEPLGFEIKWAGRHPVT *FCNDRS*YTQRPPGNA*SKLFCM*LQLQFCDI LFWQVGRVLFFAGFWNILSCSQAPDLGESKSYR GSRKCCV*CSFSVNVGCW*NFQL*HLTRGE*CLC KYFHLWLVGGGGGGSLSCLL*ISLLG*LLYFVT *SVL*LFCFLQMKNKIKTDFRKDTTSDS*CCTC SFSLFLCTVLIDNKLPFHCI

Frame 2

SAPGEASSAGEPRSSAPGRGAPRWRWQRRNCTR KGCKP*QKKERGRLK*KASDNSLTSRYFCCSIP SPKCFGRNGCCRAYPLELPKRRKPGGGSLKRMS SESSNLKITFRGWSKKYKR*KVKSPRYLPKSKSS *RN*RKQKNPSRTFRRVSPVRMELCTPWKLMWR KTNKQERPRFSLHLPLAQRGSIRKESKSMMMVP K*CMRCAQEAP**KMECTN*AQRM*KSLFRRLDN QA*EEGTCLKGL*LQMGASAIPRNTCSAKKLS* KWYISLGKTILPGTQGSRPKPPALQGRRQTWIS PSP*FLWATKISRMKRRRKRC*AMMKPSRLNWSS LMKMMRSH*GRRQ*RTCPLLTGTRLSLCPGGRS QTPQSPHPQKGRKRA*LQSQPQVPKRKSAVNAV LSCDHFFLLLSSGQPVLSTTHVDLTVPLTAIL*T GSKHLPCLAVELL*SLSFFFLFLT*ETTCMCVL HSLQELAFPLNLSLCLQE*ITSFLLDWNGLFVS ASDMVALTHLTGIEPIGTGGFIL*CVPVT*SHTA MSLVSHLPPLLWIFVFISCVAKCCWL*PVASVA KSGPYLVCPI*GDAFCCLT*ASRLQYCAFMAFF LLKLK*SQCRRTQSLSQLKCRD*FHNLPISGCLS FYGLTDEPFI*EAPF*NF*GHETNIV*SISSN* SPNLGKFTSLVSILLKKCKFLYCFFFLDIFWSC *SIFNEEIILRSIFAVTIFLKQSVQPTMVAMMLP LHHGWCCNALTVHLLPS*LQSLASILFSFWPHE KENVLGNFNL*VYLPFKKKNFKKLLKIKKDLSS QC*ALNFITNIKWHIAELLRALFCF*LLEIPEEQ RIFFI*NTMNSF*NTFSALPQSKKPHM**NQRE TI**NNNSIVMK*RYNMITGFNKSYLNFKLFAH L*HCYELFIKLCPTVYSFEKTYDILHPV*LLWKV DQKK*DSLERILL*KLSNLTYFACSVLNLLLFF NLLA*NYIYFNRKGKNISFYFSKLIF*NNCILM STKWVILFLLYSSCLHLYINRKR*RREK*RS*VL LLKIISSKAWF*ITEGNISKSQVHQSSCNGIKL LFYRETWFGCL*IPLLSASFS*VRGH*SII*TL HKLACR*TYLHRGRKQFQCLGQSVILMIYLRKKQ SESLP*LIFSTHLEIQAIQCEF*KVKHS**VKW *NVEPLSLLVDKQNQSSRTDNSLKGPILA*VN* LLIQKMICTSYYNTTHKN*KINDYLYSLH*LLLW GNND*QII*IRVLSILLLVKLII*WTEVRCVTF IRAICSHTK*RCV*IWRIYLHMSHHFLVIMGNS GLASTSMG*DL*SHL*QQVTTLHDDSVHGAVIMN MLPFLLPLAFSL*ILLCVVSHSPKMQGIWLHNQ TN*RISNEIAKP*SFLS**LVGLSFKII*SGRV QRLTPVISALWKSAAGGSPEVGSSRPA*PTWRNP HLY*KKNTKLARRDGACL*SQLLGRLRQENRLN LGGRGCNEPRCALQPGQQRAKLHLKKKKKKKKI I*SVPF*IERGGKKKGKGGVSHLYTNRFSMAFNK RFFNG*NDKD*FYIS*KILMTSVFLTS*KYFLS FSVQ*DKLRGIFSACISFTHIIFLA*AKK**LP LKLI*QCSVTSFNIGDGVEEKVGNALMAKPKTQF P*AF*AILELFRSFQETQILLI*FGSFPKC**T CICLKRLPIPFNFLLINVFYLQASRIFCFG*SQ VFIKGGEV*ERVS*RYNIISGAKC*GQV*KQTIS LYFLQNFISRDHSTPLKITIYLMPVEPMGSKRG GREHGHRDKI*LLYQVFLCKKY*PCQYKTQMDI DRISIEDFFLFT*NLEAQSSLLIPGPTGEFYSLT GPFLEEITSSPAILVYNKNHSKVSHFTLHFCHM HICY*NHRFSA*VRHRCFRNFINTRSFRCSSIS *SRYIELQ*LG*NLKTSFVLLDSTTQQEHTVICI IKQLN**GRWDV*FLLPPVHFTKAFFWYYQENF PAFSREKEKSFIRSTMQICICVFIASANFLVKF PFQQKPKY*LFECRKV*NKDYKGEFYQGSLDQLP QHNFYITQVSLCFPSPFQYNIRRSELSHKRT*F QYENIICNFGDCRLSASKIWTALTFIKIIFQCS LLLTRKTRCFLKLMTFSILGLFSKFLQVEV*RVV FSSYCLFIITWGYFLQVTAFLQKIKIKSTSHKS *NSP*TSDSPSGVKE*KYRKKRITGWLSFYFPM VNVLYGIYVYRMYLPCDVNKMNDKK*Y*CAI*QF ALASLFMFFFSVLFGKKKRRLYSKAVLTQHSLP HSYPAFFRAVNFITGALRQNLAGVAQRG*SGHR LGFTSARLPTKHVSVFSYKPAKFYTLPFRETGHM ERMTSCSRLLTVLPTVREGNLQTPNWIWEHIFK HSWHCLKKQERWTQIL*LSHD*GMCPFVIVEDE *DDMGENRSGCRNGIFYSYVFF*GIVFL**NLYT LWSLSWKTPLTELFLHSIKGNFLGSPIALGQAL GA*TKGLSLGLALPLHEIQCFQIGLGWKIELSI PAIR*IR*MA**LSGLYF**YIIIFGKEIAILNA SKAQKLSKSKSFTYLRSNCHI*G*GTTYYGAFE KYI*NGESEPSDHLQSTHKQINHQYKSYRGQTR WLMPVIPALWGAKAGG*CEPRSSRPG*ATC*DHV V*SLLKNIKISQHGGTHL*SQLLGRLRQEDHLS PGGGGCRGLRSHHSIPAWATEQDSVSKKKTKKQ LSVGLLHNTGLHCIFRVK*IQEKIVFIHKGDSEF LEFLNIFPQVSVKFLKSLPYHTQFPEALPLHLL LCLANRVVMSQKLLTTLVRLSSQASSFLRMRPF STTQEIKTLFLTRQGYIYSIFKRNNPSGSHANRL NSFITRISPTGPTPAQL*TLLSWRQLQNERTMQ LPEGANGEPVYSNLLLLRNLSVSRLSGQGDIQS LSFAMTGLDIHRGHQAMPDPNYSVCSSNSNSVIS YSGRWEEFYSLQGSGTFFPALKLLT*ESQNHTG VPENVVSDAASQ*M*VVGEIFSFSISLGVSDVS VNTFICGWLVGVGVGACRAYSELAYWASCCTL*P EVYFDCSVSFR*KTK*KPTSEKTLPATADAVLV ASLCSSVQY**TINCLFTAS

Sequence NM_053016

ACTCGGCTCCGGGAGAGGCGAGCAGCGCCGGTGAGCCCCGCAGCAGCGCACCCGGCCGCGGAGCCCCGCGATGGAGATGGCAGAGGCGGAATTGCACAAG GAAAGGCTGCAAGCCATAGCAGAAAAAAGAAAGAGGCAGACTGAAATAGAAGGCAAGCGACAACAGCTTGACGAGCAGATACTTCTGCTGCAGCATTCCA AGTCCAAAGTGCTTCGGGAGAAATGGCTGCTGCAGGGCATACCCGCTGGAACTGCCGAAGAGGAGGAAGCCAGGAGGCGGCAGTCTGAAGAGGATGAGTT CAGAGTCAAGCAACTTGAAGATAACATTCAGAGGCTGGAGCAAGAAATACAAACGCTAGAAAGTGAAGAGTCCCAGATATCTGCCAAAGAGCAAATCATC CTAGAGAAACTGAAGGAAACAGAAAAATCCTTCAAGGACTTTCAGAAGGGTTTCTCCAGTACGGATGGAGATGCAGTAAATTACATTTCCTCCCAGCTTC CCGACCTGCCAATCCTCTGTTCACGAACAGCAGAACCATCACCTGGGCAGGACGGGACCAGCAGAGCGGCTGCTGTGTACGCCATGGAAATTAATGTGGA GAAAGACAAACAAACAGGAGAGACCAAGATTCTCTCTACATCTACCATTGGCCCAGAGGGGGTCCATCAGAAAGGAGTCAAAGTCTATGATGATGGTACC AAAGTAGTGTATGAGGTGCGCTCAGGAGGCACCGTAGTAGAAAATGGAGTGCACAAATTAAGCACAAAGGATGTAGAAGAGCTTATTCAGAAGGCTGGAC AATCAAGCTTAGGAGGAGGGCACGTGTCTGAAAGGACTGTGATTGCAGATGGGAGCCTCAGCCATCCCAAGGAACACATGCTCTGCAAAGAAGCTAAGTT AGAAATGGTACATAAGTCTAGGAAAGACCATTCTTCCGGGAACCCAGGGCAGCAGGCCCAAGCCCCCAGCGCTGCAGGGCCGGAGGCAAACTTGGATCAG CCCGTCACCATGATTTTTATGGGCTACCAAAATATCGAGGATGAAGAGGAGACGAAAAAGGTGCTAGGCTATGATGAAACCATCAAGGCTGAATTGGTCC TCATTGATGAAGATGATGAGAAGTCATTGAGGGAGAAGACAGTGACGGACGTGTCCACTATTGACGGGAACGCGGCTGAGCTTGTGTCCGGGAGGCCGGT CTCAGACACCACAGAGCCCTCATCCCCAGAAGGGAAGGAAGAGAGCCTAGCTACAGAGCCAGCCCCAGGTACCCAAAAGAAAAAGCGCTGTCAATGCTGT GTTGTCATGTGACCACTTCTTTCTTCTCCTTTCTTCTGGGCAGCCTGTACTCTCCACCACTCACGTAGACCTCACTGTACCACTAACTGCAATACTGTGA ACTGGAAGCAAACACCTGCCTTGCCTTGCAGTTGAATTGCTTTGATCTCTCTCATTTTTTTTCCTTTTCCTCACCTGAGAGACAACGTGCATGTGTGTGC TTCATTCTCTCCAAGAACTTGCTTTTCCTCTAAACCTTTCCTTGTGTCTTCAAGAGTGAATCACTTCCTTCCTGCTCGATTGGAATGGACTCTTCGTATC AGCCAGTGATATGGTAGCCTTAACTCACTTGACTGGAATTGAACCCATTGGCACTGGGGGTTTCATTTTGTAGTGTGTTCCTGTAACGTAGTCACACACT GCCATGTCTCTGGTTTCTCACTTGCCTCCTTTGCTGTGGATCTTTGTTTTTATATCTTGTGTGGCAAAATGCTGTTGGCTCTAGCCGGTTGCTAGTGTAG CCAAAAGTGGACCTTACTTAGTCTGTCCGATCTAGGGTGATGCTTTTTGCTGCCTTACATAAGCTTCCAGATTACAGTATTGTGCATTCATGGCTTTCTT TCTGTTAAAACTGAAATGAAGTCAATGTAGAAGAACCCAGAGCTTGTCACAGCTGAAATGTAGGGACTGATTCCATAACCTGCCCATCAGCGGTTGTCTC TCTTTCTATGGTTTAACCGATGAACCCTTTATATAAGAAGCACCATTTTAAAATTTCTAAGGACATGAAACAAACATTGTTTGAAGCATCAGTAGCAATT GATCTCCAAACTTAGGCAAATTCACAAGCCTTGTTTCTATTCTCTTAAAAAAATGTAAATTTTTATATTGTTTCTTTTTTCTGGATATTTTCTGGTCATG TTAATCTATTTTCAATGAGGAGATCATCTTGAGAAGTATCTTTGCAGTGACCATATTTCTAAAACAGTCTGTCCAACCTACAATGGTTGCCATGATGCTC CCACTTCATCATGGATGGTGCTGTAATGCATTAACTGTTCATCTCCTCCCCAGTTGATTACAAAGCCTTGCATCCATACTCTTTTCTTTCTGGCCCCATG AGAAAGAGAATGTTTTAGGTAACTTCAACTTGTAGGTTTATCTGCCCTTCAAAAAAAAAAACTTTAAAAAACTTTTAAAAATTAAGAAAGACCTATCTTC TCAATGTTAAGCACTTAATTTCATAACAAATATTAAGTGGCACATAGCTGAGCTTCTTAGGGCATTGTTTTGTTTTTAGCTTCTGGAGATTCCAGAAGAG CAAAGAATATTTTTTATCTAGAACACAATGAACAGTTTTTGAAATACCTTCTCAGCACTCCCCCAAAGCAAAAAGCCACATATGTAGTAAAACCAAAGGG AAACAATTTAATAAAATAACAATAGTATAGTAATGAAATAAAGATATAACATGATTACTGGTTTTAATAAGAGTTATCTTAACTTTAAGTTATTTGCCCA TTTATAGCATTGTTATGAATTATTCATAAAATTATGTCCCACAGTATATAGTTTTGAAAAAACATATGATATACTACATCCAGTCTAACTTCTGTGGAAA GTAGATCAGAAAAAATAAGATAGTCTTGAGAGAATTTTATTATAGAAGCTGTCTAATTTGACCTATTTTGCTTGCTCAGTGCTAAATCTATTGCTTTTTT TTAATCTCCTGGCTTGAAATTATATTTACTTCAATAGGAAAGGTAAAAACATCAGTTTTTACTTTTCAAAGTTAATTTTCTGAAATAATTGCATTTTAAT GAGCACAAAATGGGTCATTTTATTTTTATTATACTCATCTTGTTTACACCTATACATAAACAGAAAACGTTAAAGAAGAGAAAAATAAAGGAGCTAAGTT CTGCTGTTGAAGATTATTTCATCCAAGGCTTGGTTTTGAATAACTGAGGGAAATATCTCTAAATCTCAAGTTCATCAAAGCAGCTGCAATGGAATAAAAT TGCTATTTTATCGAGAAACCTGGTTTGGATGCTTATAAATTCCACTACTCTCAGCTTCATTTTCCTGAGTACGTGGTCACTGAAGCATCATTTAGACATT ACATAAACTGGCATGCAGATAAACCTATTTACATAGAGGGAGAAAACAGTTTCAATGTCTTGGACAATCTGTTATTTTAATGATTTACTTAAGAAAGAAA CAATCTGAAAGCTTACCATAGCTTATCTTTTCTACTCACTTGGAGATTCAAGCTATTCAATGTGAGTTTTAAAAAGTTAAGCACAGTTAGTGAGTGAAAT GGTAGAATGTAGAACCTTTAAGCTTGCTGGTTGATAAACAGAATCAATCTTCCAGGACAGATAATTCCCTGAAGGGACCTATCCTTGCATAAGTGAACTA GTTACTCATACAGAAAATGATCTGCACATCTTACTACAACACTACACACAAGAACTAAAAGATTAATGATTATCTGTATTCTCTTCACTAATTACTATTA TGGGGGAATAATGATTAGCAAATTATATGAATTCGAGTTCTCTCTATACTTTTATTAGTAAAGCTTATCATTTAATGGACTGAAGTAAGATGTGTTACCT TTATTCGAGCTATTTGTAGCCACACTAAATGAAGGTGTGTTTGAATATGGCGCATATATTTGCATATGTCCCATCATTTTCTTGTCATAATGGGGAATTC AGGCTTAGCCAGTACTTCTATGGGATGAGACCTATAATCCCACCTATAGCAGCAAGTAACTACCCTTCATGATGATAGTGTACATGGAGCTGTGATTATG AACATGCTGCCTTTCCTGCTGCCATTGGCATTCTCTCTGTAAATTTTATTATGTGTGGTATCACACTCTCCAAAAATGCAGGGTATTTGGTTACATAACC AAACTAATTAAAGAATCAGTAATGAAATTGCAAAACCATGATCTTTTTTGAGCTAATGATTAGTTGGGCTTTCCTTTAAAATAATATAATCAGGCCGAGT GCAGCGGCTCACACCTGTAATCTCGGCACTTTGGAAGTCCGCGGCGGGTGGTTCACCTGAGGTCGGGAGTTCAAGACCAGCCTGACCAACATGGAGAAAC CCCCATCTCTACTAAAAAAAAAATACAAAATTAGCCAGGCGTGATGGCGCATGCCTGTAATCCCAGCTACTCGGGAGACTGAGGCAGGAGAATCGCTTGA ACCTGGGAGGCAGGGGTTGCAATGAGCCGAGATGTGCACTCCAGCCTGGGCAACAAAGAGCGAAACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAAT CATATAATCAGTTCCCTTTTAAATAGAAAGAGGAGGAAAAAAAAAAGGAAAAGGGGGGGTATCTCATTTGTATACAAATAGATTTTCAATGGCATTTAAT AAAAGATTCTTTAATGGTTAAAATGATAAAGATTAATTCTACATATCTTGAAAAATCTTAATGACTTCTGTATTCTTGACTTCTTAAAAATATTTTCTTT CTTTTAGTGTGCAATAAGACAAACTAAGGGGAATTTTTTCAGCTTGTATCTCTTTTACCCATATTATTTTCCTTGCATAAGCAAAAAAATAATAATTGCC TCTAAAACTGATTTGACAGTGTTCAGTGACATCATTTAATATTGGTGATGGGGTGGAAGAGAAGGTAGGGAATGCCCTTATGGCCAAACCTAAAACACAG TTTCCTTGAGCCTTCTGAGCAATCTTAGAATTATTCAGAAGCTTTCAGGAAACTCAAATTCTATTAATTTGATTTGGTTCCTTTCCAAAATGTTAATAGA CATGTATTTGCTTAAAACGTCTACCTATTCCATTTAATTTCCTGCTGATAAATGTATTTTATCTACAAGCAAGTAGAATATTTTGTTTTGGTTAAAGTCA AGTTTTTATAAAAGGAGGGGAAGTATAAGAGAGAGTTTCCTAGAGATACAATATCATCTCTGGAGCAAAATGTTGAGGCCAAGTGTAAAAACAGACTATT TCTCTTTACTTCCTGCAGAATTTCATTTCAAGGGACCACAGCACACCCTTGAAAATTACCATTTATTTAATGCCAGTTGAACCAATGGGTAGCAAAAGAG GAGGGAGGGAACATGGTCATAGAGACAAAATCTAACTACTATACCAGGTCTTCCTTTGTAAGAAATATTAGCCCTGCCAATATAAAACGCAGATGGACAT AGACAGAATAAGCATCGAGGACTTTTTCTTATTTACTTGAAATCTAGAAGCTCAGTCATCTCTGCTCATCCCTGGACCCACTGGAGAGTTTTACTCACTA ACAGGTCCTTTCCTGGAAGAAATAACCTCATCTCCTGCCATATTAGTTTACAATAAAAATCATTCCAAAGTGAGCCATTTCACATTGCATTTTTGCCACA TGCACATTTGCTATTGAAACCACAGATTCTCAGCATAAGTAAGACATAGGTGTTTCAGAAACTTCATAAATACACGATCTTTCAGGTGCTCCTCAATTTC TTAATCAAGGTATATTGAACTCCAGTGATTAGGATAGAACCTGAAAACATCCTTTGTTCTATTGGATAGTACAACACAGCAAGAGCACACAGTTATTTGT ATAATAAAACAACTTAATTAATGAGGAAGATGGGATGTTTGATTCCTGCTACCACCAGTTCACTTCACAAAGGCCTTCTTCTGGTATTACCAGGAAAACT TTCCTGCATTTTCTAGGGAAAAAGAAAAGTCGTTTATTAGGAGCACAATGCAGATATGTATCTGTGTTTTCATAGCTTCAGCAAACTTCTTAGTAAAATT CCCATTTCAACAAAAACCAAAATACTGATTGTTTGAATGTAGAAAGGTATAGAATAAAGACTACAAAGGGGAATTTTACCAGGGCTCCTTAGACCAGCTT CCCCAGCATAATTTTTATATAACTCAAGTAAGCCTCTGCTTCCCCTCTCCTTTCCAGTATAATATAAGAAGGTCGGAACTGTCGCACAAAAGAACTTGAT TTCAATATGAAAATATAATATGTAATTTTGGGGACTGCAGACTTTCTGCATCAAAGATCTGGACAGCCTTAACTTTTATAAAAATAATTTTTCAATGTTC TCTTTTACTAACCAGGAAAACAAGATGTTTTCTGAAATTAATGACTTTTTCTATTTTGGGTCTGTTTTCTAAGTTTTTACAGGTTGAGGTATAAAGGGTC GTCTTCTCCTCATATTGCCTCTTCATAATCACCTGGGGCTATTTTTTGCAAGTCACTGCATTTTTACAAAAAATAAAAATAAAAAGTACATCTCACAAAT CATAAAATTCTCCCTAGACTTCAGACAGTCCTTCTGGAGTGAAAGAATAGAAATACAGAAAGAAAAGAATTACAGGGTGGCTTTCTTTTTATTTTCCTAT GGTTAATGTACTGTATGGTATATATGTTTACAGAATGTATCTGCCTTGTGATGTTAACAAAATGAATGACAAAAAATAGTACTGATGTGCCATTTGACAG TTTGCCTTAGCATCACTGTTTATGTTCTTCTTTTCTGTCCTTTTTGGTAAAAAAAAACGCAGGTTGTATTCCAAAGCTGTATTAACACAACATTCTCTTC CCCACTCCTACCCAGCCTTCTTCAGAGCTGTGAATTTCATTACAGGAGCATTGAGGCAGAACCTTGCAGGTGTGGCCCAAAGGGGCTAAAGTGGGCATAG GTTGGGATTTACTTCTGCCCGTCTACCAACCAAACACGTATCTGTGTTCTCATATAAGCCTGCAAAATTTTACACCCTGCCTTTCAGGGAGACAGGCCAC ATGGAGCGCATGACCTCTTGTAGTCGTCTCCTCACAGTCCTTCCCACTGTGAGAGAAGGAAACTTGCAGACCCCCAACTGGATCTGGGAGCATATTTTTA AGCACAGTTGGCATTGCTTGAAAAAGCAAGAGAGATGGACTCAAATTCTATGATTGAGCCATGACTGAGGAATGTGCCCATTCGTTATAGTCGAAGATGA GTAGGATGATATGGGTGAGAATAGGAGTGGCTGTAGAAATGGAATATTTTACAGTTATGTATTTTTTTAAGGAATAGTATTTTTATAATGAAATCTATAT ACATTATGGAGCTTGAGTTGGAAAACACCCTTGACTGAGCTATTTCTTCATTCCATTAAAGGTAACTTTCTGGGGAGTCCTATAGCACTAGGCCAAGCCT TGGGGGCATGAACAAAGGGCCTGTCACTTGGCCTTGCACTGCCATTACATGAGATCCAGTGTTTCCAAATAGGCCTTGGTTGGAAGATTGAGCTTTCTAT ACCTGCCATTAGGTAGATTAGATAGATGGCTTGATAGCTCTCTGGGCTATACTTTTAATAATATATAATAATCTTTGGGAAGGAGATAGCTATTTTAAAT GCAAGCAAAGCCCAGAAACTATCAAAGTCCAAATCTTTCACATATTTAAGGAGTAATTGCCACATTTGAGGTTAAGGGACCACTTACTATGGTGCATTTG AGAAATATATATGAAACGGTGAGTCAGAGCCCTCTGACCATCTTCAGTCTACACATAAGCAGATAAACCACCAATATAAATCTTATAGGGGCCAGACGAG GTGGCTTATGCCTGTAATCCCAGCACTTTGGGGGGCCAAGGCAGGAGGATAGTGTGAGCCCAGAAGTTCAAGACCAGGCTAGGCAACATGTTGAGACCAT GTTGTTTAGTCTCTACTAAAAAATATAAAAATTAGCCAGCATGGTGGCACACACCTGTAGTCCCAGCTACTTGGGAGACTGAGGCAGGAGGATCACTTGA GCCCAGGAGGTGGAGGCTGCAGGGGGCTGAGATCTCACCACTCCATTCCAGCCTGGGCAACAGAGCAAGACTCTGTCTCAAAAAAAAAAACAAAAAAACA ATTATCAGTTGGCCTTCTACATAACACAGGGCTACACTGTATTTTTAGAGTTAAGTAGATACAGGAAAAGATTGTCTTTATCCATAAAGGAGATTCTGAA TTTTTAGAGTTCCTGAATATTTTCCCCCAAGTTTCTGTCAAATTCCTGAAGTCCCTTCCCTATCACACTCAGTTTCCTGAAGCTCTTCCCCTACACCTGC TCCTCTGTCTGGCTAACAGAGTTGTCATGTCTCAGAAACTACTCACCACTCTTGTGAGACTCTCTTCCCAAGCATCATCCTTCCTCAGGATGAGGCCTTT TTCTACTACCCAAGAGATCAAGACCCTTTTTCTAACAAGACAAGGTTATATCTACTCCATTTTCAAGAGAAATAACCCCTCTGGTTCCCATGCAAATCGC TTAAATTCCTTCATCACCAGAATCTCTCCAACAGGCCCAACTCCAGCCCAGCTGTGAACACTGCTGTCATGGAGACAACTCCAAAATGAAAGAACTATGC AATTGCCTGAAGGTGCTAATGGAGAGCCAGTTTACTCTAATCTCTTATTACTAAGGAACCTCTCGGTTTCGAGATTAAGTGGGCAGGGAGACATCCAGTC ACTTAGTTTTGCAATGACAGGTCTTGATATACACAGAGGCCACCAGGCAATGCCTGATCCAAACTATTCTGTATGTAGCTCCAACTCCAATTCTGTGATA TCCTATTCTGGCAGGTGGGAAGAGTTCTATTCTTTGCAGGGTTCTGGAACATTCTTTCCTGCTCTCAAGCTCCTGACTTAGGAGAGTCAAAATCATACAG GGGTTCCAGAAAATGTTGTGTCTGATGCAGCTTCTCAGTGAATGTAGGTTGTTGGTGAAATTTTCAGCTTTAGCATCTCACTCGGGGTGAGTGATGTCTC TGTAAATACTTTCATTTGTGGTTGGTTGGTGGGGGTGGGGGTGGGAGCCTGTCGTGCTTACTCTGAATTAGCTTACTGGGCTAGCTGCTGTACTTTGTAA CCTGAAGTGTACTTTGACTGTTCTGTTTCCTTCAGATGAAAAACAAAATAAAAACCGACTTCAGAAAAGACACTACCAGCGACAGCTGATGCTGTACTTG TAGCTTCTCTCTGTTCCTCTGTACAGTATTAATAGACAATAAACTGCCTTTTCACTGCATCTA

refseq_PALM2.F1 (forward primer)
refseq_PALM2.R1 (reverse primer)
Single exon skipping

Frame 0

TRLRERRAAPVSPAAAHPAAEPRDGDGRGGIAQ GKAASHSRKKKEAD*NRRQATTA*RADTSAAAFQ VQSASGEMAAAGHTRWNCRRGGSQEAAV*RG*V QSQAT*R*HSEAGARNTNARK*RVPDICQRANH PRETEGNRKILQGLSEGFLQYGWRCSKLHFLPAS RPANPLFTNSRTITWAGRDQQSGCCVRHGN*CG ERQTNRRDQDSLYIYHWPRGGPSERSQSL**WY QSSV*GALRRHRSRKWSAQIKHKGCRRAYSEGWT IKLRRRARV*KDCDCRWEPQPSQGTHALQRS*V RNGT*V*ERPFFREPRAAGPSPQRCRAGGKLGS ARHHDFYGLPKYRG*RGDEKGARL**NHQG*IGP H**R**EVIEGEDSDGRVHY*RERG*ACVREAG LRHHRALIPRREGREPSYRASPRYPKEKALSML CCHVTTSFFSFLLGSLYSPPLT*TSLYH*LQYCE LEANTCLALQLNCFDLSHFFSFSSPERQRACVC FILSKNLLFL*TFPCVFKSESLPSCSIGMDSSY QPVIW*P*LT*LELNPLALGVSFCSVFL*RSHTL PCLWFLTCLLCCGSLFLYLVWQNAVGSSRLLV* PKVDLT*SVRSRVMLFAALHKLPDYSIVHSWLS FC*N*NEVNVEEPRACHS*NVGTDSITCPSAVVS LSMV*PMNPLYKKHHFKISKDMKQTLFEASVAI DLQT*ANSQALFLFS*KNVNFYIVSFFWIFSGH VNLFSMRRSS*EVSLQ*PYF*NSLSNLQWLP*CS HFIMDGAVMH*LFISSPVDYKALHPYSFLSGPM RKRMF*VTSTCRFICPSKKKTLKNF*KLRKTYL LNVKHLIS*QILSGT*LSFLGHCFVFSFWRFQKS KEYFLSRTQ*TVFEIPSQHSPKAKSHICSKTKG KQFNKITIV***NKDIT*LLVLIRVILTLSYLP IYSIVMNYS*NYVPQYIVLKKHMIYYIQSNFCGK *IRKNKIVLREFYYRSCLI*PILLAQC*IYCFF LISWLEIIFTSIGKVKTSVFTFQS*FSEIIAF* *AQNGSFYFYYTHLVYTYT*TENVKEEKNKGAKF CC*RLFHPRLGFE*LREISLNLKFIKAAAME*N CYFIEKPGLDAYKFHYSQLHFPEYVVTEASFRH YINWHADKPIYIEGENSFNVLDNLLF**FT*ERN NLKAYHSLSFLLTWRFKLFNVSFKKLSTVSE*N GRM*NL*ACWLINRINLPGQIIP*RDLSLHK*T SYSYRK*SAHLTTTLHTRTKRLMIICILFTNYYY GGIMISKLYEFEFSLYFY**SLSFNGLK*DVLP LFELFVATLNEGVFEYGAYICICPIIFLS*WGI QA*PVLLWDETYNPTYSSK*LPFMMIVYMEL*L* TCCLSCCHWHSLCKFYYVWYHTLQKCRVFGYIT KLIKESVMKLQNHDLF*AND*LGFPLK*YNQAE CSGSHL*SRHFGSPRRVVHLRSGVQDQPDQHGET PISTKKKIQN*PGVMAHACNPSYSGD*GRRIA* TWEAGVAMSRDVHSSLGNKERNSISKKKKKKKK SYNQFPFK*KEEEKKKEKGGYLICIQIDFQWHLI KDSLMVKMIKINSTYLEKS**LLYS*LLKNIFF LLVCNKTN*GEFFQLVSLLPILFSLHKQKNNNC L*N*FDSVQ*HHLILVMGWKRR*GMPLWPNLKHS FLEPSEQS*NYSEAFRKLKFY*FDLVPFQNVNR HVFA*NVYLFHLISC**MYFIYKQVEYFVLVKV KFL*KEGKYKREFPRDTISSLEQNVEAKCKNRLF LFTSCRISFQGTTAHP*KLPFI*CQLNQWVAKE EGGNMVIETKSNYYTRSSFVRNISPANIKRRWT *TE*ASRTFSYLLEI*KLSHLCSSLDPLESFTH* QVLSWKK*PHLLPY*FTIKIIPK*AISHCIFAT CTFAIETTDSQHK*DIGVSETS*IHDLSGAPQF LNQGILNSSD*DRT*KHPLFYWIVQHSKSTQLFV **NNLINEEDGMFDSCYHQFTSQRPSSGITRKT FLHFLGKKKSRLLGAQCRYVSVFS*LQQTS**N SHFNKNQNTDCLNVERYRIKTTKGNFTRAP*TSF PSIIFI*LK*ASASPLLSSII*EGRNCRTKELD FNMKI*YVILGTADFLHQRSGQP*LL*K*FFNV LFY*PGKQDVF*N**LFLFWVCFLSFYRLRYKGS SSPHIASS*SPGAIFCKSLHFYKK*K*KVHLTN HKILPRLQTVLLE*KNRNTERKELQGGFLFIFL WLMYCMVYMFTECICLVMLTK*MTKNSTDVPFDS LP*HHCLCSSFLSFLVKKNAGCIPKLY*HNILF PTPTQPSSEL*ISLQEH*GRTLQVWPKGAKVGI GWDLLLPVYQPNTYLCSHISLQNFTPCLSGRQAT WSA*PLVVVSSQSFPL*EKETCRPPTGSGSIFL STVGIA*KSKRDGLKFYD*AMTEECAHSL*SKM SRMIWVRIGVAVEMEYFTVMYFFKE*YFYNEIYI HYGA*VGKHP*LSYFFIPLKVTFWGVL*H*AKP WGHEQRACHLALHCHYMRSSVSK*ALVGRLSFL YLPLGRLDRWLDSSLGYTFNNI**SLGRR*LF*M QAKPRNYQSPNLSHI*GVIATFEVKGPLTMVHL RNIYETVSQSPLTIFSLHISR*TTNINLIGARR GGLCL*SQHFGGPRQEDSVSPEVQDQARQHVETM LFSLY*KI*KLASMVAHTCSPSYLGD*GRRIT* AQEVEAAGG*DLTTPFQPGQQSKTLSQKKKQKN NYQLAFYITQGYTVFLELSRYRKRLSLSIKEILN F*SS*IFSPKFLSNS*SPFPITLSFLKLFPYTC SSVWLTELSCLRNYSPLL*DSLPKHHPSSG*GL FLLPKRSRPFF*QDKVISTPFSREITPLVPMQIA *IPSSPESLQQAQLQPSCEHCCHGDNSKMKELC NCLKVLMESQFTLISYY*GTSRFRD*VGRETSS HLVLQ*QVLIYTEATRQCLIQTILYVAPTPIL*Y PILAGGKSSILCRVLEHSFLLSSS*LRRVKIIQ GFQKMLCLMQLLSECRLLVKFSALASHSG*VMS L*ILSFVVGWWGWGWEPVVLTLN*LTGLAAVLCN LKCTLTVLFPSDEKQNKNRLQKRHYQRQLMLYL *LLSVPLYSINRQ*TAFSLHL

Frame 1

LGSGRGEQRR*APQQRTRPRSPAMEMAEAELHK ERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHS KSKVLREKWLLQGIPAGTAEEEEARRRQSEEDEF RVKQLEDNIQRLEQEIQTLESEESQISAKEQII LEKLKETEKSFKDFQKGFSSTDGDAVNYISSQL PDLPILCSRTAEPSPGQDGTSRAAAVYAMEINVE KDKQTGETKILSTSTIGPEGVHQKGVKVYDDGT KVVYEVRSGGTVVENGVHKLSTKDVEELIQKAG QSSLGGGHVSERTVIADGSLSHPKEHMLCKEAKL EMVHKSRKDHSSGNPGQQAQAPSAAGPEANLDQ PVTMIFMGYQNIEDEEETKKVLGYDETIKAELV LIDEDDEKSLREKTVTDVSTIDGNAAELVSGRPV SDTTEPSSPEGKEESLATEPAPGTQKKKRCQCC VVM*PLLSSPFFWAACTLHHSRRPHCTTNCNTV NWKQTPALPCS*IALISLIFFPFPHLRDNVHVCA SFSPRTCFSSKPFLVSSRVNHFLPARLEWTLRI SQ*YGSLNSLDWN*THWHWGFHFVVCSCNVVTH CHVSGFSLASFAVDLCFYILCGKMLLALAGC*CS QKWTLLSLSDLG*CFLLPYISFQITVLCIHGFL SVKTEMKSM*KNPELVTAEM*GLIP*PAHQRLS LFLWFNR*TLYIRSTILKFLRT*NKHCLKHQ*QL ISKLRQIHKPCFYSLKKM*IFILFLFSGYFLVM LIYFQ*GDHLEKYLCSDHISKTVCPTYNGCHDA PTSSWMVL*CINCSSPPQLITKPCIHTLFFLAP* ERECFR*LQLVGLSALQKKKL*KTFKN*ERPIF SMLST*FHNKY*VAHS*AS*GIVLFLASGDSRR AKNIFYLEHNEQFLKYLLSTPPKQKATYVVKPKG NNLIK*Q*YSNEIKI*HDYWF**ELS*L*VICP FIALL*IIHKIMSHSI*F*KNI*YTTSSLTSVE SRSEKIR*S*ENFIIEAV*FDLFCLLSAKSIAFF *SPGLKLYLLQ*ER*KHQFLLFKVNFLK*LHFN EHKMGHFIFIILILFTPIHKQKTLKKRKIKELS SAVEDYFIQGLVLNN*GKYL*ISSSSKQLQWNKI AILSRNLVWMLINSTTLSFIFLSTWSLKHHLDI T*TGMQINLFT*REKTVSMSWTICYFNDLLKKE TI*KLTIAYLFYSLGDSSYSM*VLKS*AQLVSEM VECRTFKLAG**TESIFQDR*FPEGTYPCISEL VTHTENDLHILLQHYTQELKD**LSVFSSLITI MGE**LANYMNSSSLYTFISKAYHLMD*SKMCYL YSSYL*PH*MKVCLNMAHIFAYVPSFSCHNGEF RLSQYFYGMRPIIPPIAASNYPS***CTWSCDY EHAAFPAAIGILSVNFIMCGITLSKNAGYLVT*P N*LKNQ**NCKTMIFFELMISWAFL*NNIIRPS AAAHTCNLGTLEVRGGWFT*GREFKTSLTNMEK PPSLLKKKYKISQA*WRMPVIPATRETEAGESLE PGRQGLQ*AEMCTPAWATKSETPSQKKKKKKKN HIISSLLNRKRRKKKRKRGGISFVYK*IFNGI* *KIL*WLK**RLILHILKNLNDFCILDFLKIFSF F*CAIRQTKGNFFSLYLFYPYYFPCISKKIIIA SKTDLTVFSDII*YW*WGGREGRECPYGQT*NT VSLSLLSNLRIIQKLSGNSNSINLIWFLSKMLID MYLLKTSTYSI*FPADKCILSTSK*NILFWLKS SFYKRRGSIRESFLEIQYHLWSKMLRPSVKTDY FSLLPAEFHFKGPQHTLENYHLFNAS*TNG*QKR REGTWS*RQNLTTIPGLPL*EILALPI*NADGH RQNKHRGLFLIYLKSRSSVISAHPWTHWRVLLT NRSFPGRNNLISCHISLQ*KSFQSEPFHIAFLPH AHLLLKPQILSISKT*VFQKLHKYTIFQVLLNF LIKVY*TPVIRIEPENILCSIG*YNTARAHSYL YNKTT*LMRKMGCLIPATTSSLHKGLLLVLPGKL SCIF*GKRKVVY*EHNADMYLCFHSFSKLLSKI PISTKTKILIV*M*KGIE*RLQRGILPGLLRPA SPA*FLYNSSKPLLPLSFPV*YKKVGTVAQKNLI SI*KYNM*FWGLQTFCIKDLDSLNFYKNNFSMF SFTNQENKMFSEINDFFYFGSVF*VFTG*GIKG RLLLILPLHNHLGLFFASHCIFTKNKNKKYISQI IKFSLDFRQSFWSERIEIQKEKNYRVAFFLFSY G*CTVWYICLQNVSAL*C*QNE*QKIVLMCHLT VCLSITVYVLLFCPFW*KKTQVVFQSCINTTFSS PLLPSLLQSCEFHYRSIEAEPCRCGPKGLKWA* VGIYFCPSTNQTRICVLI*ACKILHPAFQGDRP HGAHDLL*SSPHSPSHCERRKLADPQLDLGAYF* AQLALLEKAREMDSNSMIEP*LRNVPIRYSRR* VG*YG*E*EWL*KWNILQLCIFLRNSIFIMKSI YIMELELENTLD*AISSFH*R*LSGESYSTRPSL GGMNKGPVTWPCTAIT*DPVFPNRPWLED*AFY TCH*VD*IDGLIALWAILLIIYNNLWEGDSYFK CKQSPETIKVQIFHIFKE*LPHLRLRDHLLWCI* EIYMKR*VRAL*PSSVYT*ADKPPI*IL*GPDE VAYACNPSTLGGQGRRIV*AQKFKTRLGNMLRP CCLVSTKKYKN*PAWWHTPVVPATWETEAGGSLE PRRWRLQGAEISPLHSSLGNRARLCLKKKNKKT IISWPST*HRATLYF*S*VDTGKDCLYP*RRF* IFRVPEYFPPSFCQIPEVPSLSHSVS*SSSPTPA PLSG*QSCHVSETTHHSCETLFPSIILPQDEAF FYYPRDQDPFSNKTRLYLLHFQEK*PLWFPCKS LKFLHHQNLSNRPNSSPAVNTAVMETTPK*KNYA IA*RC*WRASLL*SLITKEPLGFEIKWAGRHPV T*FCNDRS*YTQRPPGNA*SKLFCM*LQLQFCD ILFWQVGRVLFFAGFWNILSCSQAPDLGESKSYR GSRKCCV*CSFSVNVGCW*NFQL*HLTRGE*CL CKYFHLWLVGGGGGGSLSCLL*ISLLG*LLYFV T*SVL*LFCFLQMKNKIKTDFRKDTTSDS*CCTC SFSLFLCTVLIDNKLPFHCI

Frame 2

SAPGEASSAGEPRSSAPGRGAPRWRWQRRNCTR KGCKP*QKKERGRLK*KASDNSLTSRYFCCSIP SPKCFGRNGCCRAYPLELPKRRKPGGGSLKRMS SESSNLKITFRGWSKKYKR*KVKSPRYLPKSKSS *RN*RKQKNPSRTFRRVSPVRMEMQ*ITFPPSF PTCQSSVHEQQNHHLGRTGPAERLLCTPWKLMW RKTNKQERPRFSLHLPLAQRGSIRKESKSMMMVP K*CMRCAQEAP**KMECTN*AQRM*KSLFRRLD NQA*EEGTCLKGL*LQMGASAIPRNTCSAKKLS *KWYISLGKTILPGTQGSRPKPPALQGRRQTWIS PSP*FLWATKISRMKRRRKRC*AMMKPSRLNWS SLMKMMRSH*GRRQ*RTCPLLTGTRLSLCPGGR SQTPQSPHPQKGRKRA*LQSQPQVPKRKSAVNAV LSCDHFFLLLSSGQPVLSTTHVDLTVPLTAIL* TGSKHLPCLAVELL*SLSFFFLFLT*ETTCMCV LHSLQELAFPLNLSLCLQE*ITSFLLDWNGLFVS ASDMVALTHLTGIEPIGTGGFIL*CVPVT*SHT AMSLVSHLPPLLWIFVFISCVAKCCWL*PVASV AKSGPYLVCPI*GDAFCCLT*ASRLQYCAFMAFF LLKLK*SQCRRTQSLSQLKCRD*FHNLPISGCL SFYGLTDEPFI*EAPF*NF*GHETNIV*SISSN *SPNLGKFTSLVSILLKKCKFLYCFFFLDIFWSC *SIFNEEIILRSIFAVTIFLKQSVQPTMVAMML PLHHGWCCNALTVHLLPS*LQSLASILFSFWPH EKENVLGNFNL*VYLPFKKKNFKKLLKIKKDLSS QC*ALNFITNIKWHIAELLRALFCF*LLEIPEE QRIFFI*NTMNSF*NTFSALPQSKKPHM**NQR ETI**NNNSIVMK*RYNMITGFNKSYLNFKLFAH L*HCYELFIKLCPTVYSFEKTYDILHPV*LLWK VDQKK*DSLERILL*KLSNLTYFACSVLNLLLF FNLLA*NYIYFNRKGKNISFYFSKLIF*NNCILM STKWVILFLLYSSCLHLYINRKR*RREK*RS*V LLLKIISSKAWF*ITEGNISKSQVHQSSCNGIK LLFYRETWFGCL*IPLLSASFS*VRGH*SII*TL HKLACR*TYLHRGRKQFQCLGQSVILMIYLRKK QSESLP*LIFSTHLEIQAIQCEF*KVKHS**VK W*NVEPLSLLVDKQNQSSRTDNSLKGPILA*VN* LLIQKMICTSYYNTTHKN*KINDYLYSLH*LLL WGNND*QII*IRVLSILLLVKLII*WTEVRCVT FIRAICSHTK*RCV*IWRIYLHMSHHFLVIMGNS GLASTSMG*DL*SHL*QQVTTLHDDSVHGAVIM NMLPFLLPLAFSL*ILLCVVSHSPKMQGIWLHN QTN*RISNEIAKP*SFLS**LVGLSFKII*SGRV QRLTPVISALWKSAAGGSPEVGSSRPA*PTWRN PHLY*KKNTKLARRDGACL*SQLLGRLRQENRL NLGGRGCNEPRCALQPGQQRAKLHLKKKKKKKKI I*SVPF*IERGGKKKGKGGVSHLYTNRFSMAFN KRFFNG*NDKD*FYIS*KILMTSVFLTS*KYFL SFSVQ*DKLRGIFSACISFTHIIFLA*AKK**LP LKLI*QCSVTSFNIGDGVEEKVGNALMAKPKTQ FP*AF*AILELFRSFQETQILLI*FGSFPKC** TCICLKRLPIPFNFLLINVFYLQASRIFCFG*SQ VFIKGGEV*ERVS*RYNIISGAKC*GQV*KQTI SLYFLQNFISRDHSTPLKITIYLMPVEPMGSKR GGREHGHRDKI*LLYQVFLCKKY*PCQYKTQMDI DRISIEDFFLFT*NLEAQSSLLIPGPTGEFYSL TGPFLEEITSSPAILVYNKNHSKVSHFTLHFCH MHICY*NHRFSA*VRHRCFRNFINTRSFRCSSIS *SRYIELQ*LG*NLKTSFVLLDSTTQQEHTVIC IIKQLN**GRWDV*FLLPPVHFTKAFFWYYQEN FPAFSREKEKSFIRSTMQICICVFIASANFLVKF PFQQKPKY*LFECRKV*NKDYKGEFYQGSLDQL PQHNFYITQVSLCFPSPFQYNIRRSELSHKRT* FQYENIICNFGDCRLSASKIWTALTFIKIIFQCS LLLTRKTRCFLKLMTFSILGLFSKFLQVEV*RV VFSSYCLFIITWGYFLQVTAFLQKIKIKSTSHK S*NSP*TSDSPSGVKE*KYRKKRITGWLSFYFPM VNVLYGIYVYRMYLPCDVNKMNDKK*Y*CAI*Q FALASLFMFFFSVLFGKKKRRLYSKAVLTQHSL PHSYPAFFRAVNFITGALRQNLAGVAQRG*SGHR LGFTSARLPTKHVSVFSYKPAKFYTLPFRETGH MERMTSCSRLLTVLPTVREGNLQTPNWIWEHIF KHSWHCLKKQERWTQIL*LSHD*GMCPFVIVEDE *DDMGENRSGCRNGIFYSYVFF*GIVFL**NLY TLWSLSWKTPLTELFLHSIKGNFLGSPIALGQA LGA*TKGLSLGLALPLHEIQCFQIGLGWKIELSI PAIR*IR*MA**LSGLYF**YIIIFGKEIAILN ASKAQKLSKSKSFTYLRSNCHI*G*GTTYYGAF EKYI*NGESEPSDHLQSTHKQINHQYKSYRGQTR WLMPVIPALWGAKAGG*CEPRSSRPG*ATC*DH VV*SLLKNIKISQHGGTHL*SQLLGRLRQEDHL SPGGGGCRGLRSHHSIPAWATEQDSVSKKKTKKQ LSVGLLHNTGLHCIFRVK*IQEKIVFIHKGDSE FLEFLNIFPQVSVKFLKSLPYHTQFPEALPLHL LLCLANRVVMSQKLLTTLVRLSSQASSFLRMRPF STTQEIKTLFLTRQGYIYSIFKRNNPSGSHANR LNSFITRISPTGPTPAQL*TLLSWRQLQNERTM QLPEGANGEPVYSNLLLLRNLSVSRLSGQGDIQS LSFAMTGLDIHRGHQAMPDPNYSVCSSNSNSVI SYSGRWEEFYSLQGSGTFFPALKLLT*ESQNHT GVPENVVSDAASQ*M*VVGEIFSFSISLGVSDVS VNTFICGWLVGVGVGACRAYSELAYWASCCTL* PEVYFDCSVSFR*KTK*KPTSEKTLPATADAVL VASLCSSVQY**TINCLFTAS