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Sequences

Sequence NM_001037293

ACTCGGCTCCGGGAGAGGCGAGCAGCGCCGGTGAGCCCCGCAGCAGCGCACCCGGCCGCGGAGCCCCGCGATGGAGATGGCAGAGGCGGAATTGCACAAG
GAAAGGCTGCAAGCCATAGCAGAAAAAAGAAAGAGGCAGACTGAAATAGAAGGCAAGCGACAACAGCTTGACGAGCAGATACTTCTGCTGCAGCATTCCA
AGTCCAAAGTGCTTCGGGAGAAATGGCTGCTGCAGGGCATACCCGCTGGAACTGCCGAAGAGGAGGAAGCCAGGAGGCGGCAGTCTGAAGAGGATGAGTT
CAGAGTCAAGCAACTTGAAGATAACATTCAGAGGCTGGAGCAAGAAATACAAACGCTAGAAAGTGAAGAGTCCCAGATATCTGCCAAAGAGCAAATCATC
CTAGAGAAACTGAAGGAAACAGAAAAATCCTTCAAGGACTTTCAGAAGGGTTTCTCCAGTACGGATGGAGCTGTGTACGCCATGGAAATTAATGTGGAGA
AAGACAAACAAACAGGAGAGACCAAGATTCTCTCTACATCTACCATTGGCCCAGAGGGGGTCCATCAGAAAGGAGTCAAAGTCTATGATGATGGTACCAA
AGTAGTGTATGAGGTGCG
CTCAGGAGGCACCGTAGTAGAAAATGGAGTGCACAAATTAAGCACAAAGGATGTAGAAGAGCTTATTCAGAAGGCTGGACAA
TCAAGCTTAGGAGGAGGGCACGTGTCTGAAAGGACTGTGATTGCAGATGGGAGCCTCAGCCATCCCAAGGAACACATGCTCTGCAAAGAAGCTAAGTTAG
AAATGGTACATAAGTCTAGGAAAGACCATTCTTCCGGGAACCCAGGGCAGCAGGCCCAAGCCCCCAGCGCTGCAGGGCCGGAGGCAAACTTGGATCAGCC
CGTCACCATGATTTTTATGGGCTACCAAAATATCGAGGATGAAGAGGAGACGAAAAAGGTGCTAGGCTATGATGAAACCATCAAGGCTGAATTGGTCCTC
ATTGATGAAGATGATGAGAAGTCATTGAGGGAGAAGACAGTGACGGACGTGTCCACTATTGACGGGAACGCGGCTGAGCTTGTGTCCGGGAGGCCGGTCT
CAGACACCACAGAGCCCTCATCCCCAGAAGGGAAGGAAGAGAGCCTAGCTACAGAGCCAGCCCCAGGTACCCAAAAGAAAAAGCGCTGTCAATGCTGTGT
TGTCATGTGACCACTTCTTTCTTCTCCTTTCTTCTGGGCAGCCTGTACTCTCCACCACTCACGTAGACCTCACTGTACCACTAACTGCAATACTGTGAAC
TGGAAGCAAACACCTGCCTTGCCTTGCAGTTGAATTGCTTTGATCTCTCTCATTTTTTTTCCTTTTCCTCACCTGAGAGACAACGTGCATGTGTGTGCTT
CATTCTCTCCAAGAACTTGCTTTTCCTCTAAACCTTTCCTTGTGTCTTCAAGAGTGAATCACTTCCTTCCTGCTCGATTGGAATGGACTCTTCGTATCAG
CCAGTGATATGGTAGCCTTAACTCACTTGACTGGAATTGAACCCATTGGCACTGGGGGTTTCATTTTGTAGTGTGTTCCTGTAACGTAGTCACACACTGC
CATGTCTCTGGTTTCTCACTTGCCTCCTTTGCTGTGGATCTTTGTTTTTATATCTTGTGTGGCAAAATGCTGTTGGCTCTAGCCGGTTGCTAGTGTAGCC
AAAAGTGGACCTTACTTAGTCTGTCCGATCTAGGGTGATGCTTTTTGCTGCCTTACATAAGCTTCCAGATTACAGTATTGTGCATTCATGGCTTTCTTTC
TGTTAAAACTGAAATGAAGTCAATGTAGAAGAACCCAGAGCTTGTCACAGCTGAAATGTAGGGACTGATTCCATAACCTGCCCATCAGCGGTTGTCTCTC
TTTCTATGGTTTAACCGATGAACCCTTTATATAAGAAGCACCATTTTAAAATTTCTAAGGACATGAAACAAACATTGTTTGAAGCATCAGTAGCAATTGA
TCTCCAAACTTAGGCAAATTCACAAGCCTTGTTTCTATTCTCTTAAAAAAATGTAAATTTTTATATTGTTTCTTTTTTCTGGATATTTTCTGGTCATGTT
AATCTATTTTCAATGAGGAGATCATCTTGAGAAGTATCTTTGCAGTGACCATATTTCTAAAACAGTCTGTCCAACCTACAATGGTTGCCATGATGCTCCC
ACTTCATCATGGATGGTGCTGTAATGCATTAACTGTTCATCTCCTCCCCAGTTGATTACAAAGCCTTGCATCCATACTCTTTTCTTTCTGGCCCCATGAG
AAAGAGAATGTTTTAGGTAACTTCAACTTGTAGGTTTATCTGCCCTTCAAAAAAAAAAACTTTAAAAAACTTTTAAAAATTAAGAAAGACCTATCTTCTC
AATGTTAAGCACTTAATTTCATAACAAATATTAAGTGGCACATAGCTGAGCTTCTTAGGGCATTGTTTTGTTTTTAGCTTCTGGAGATTCCAGAAGAGCA
AAGAATATTTTTTATCTAGAACACAATGAACAGTTTTTGAAATACCTTCTCAGCACTCCCCCAAAGCAAAAAGCCACATATGTAGTAAAACCAAAGGGAA
ACAATTTAATAAAATAACAATAGTATAGTAATGAAATAAAGATATAACATGATTACTGGTTTTAATAAGAGTTATCTTAACTTTAAGTTATTTGCCCATT
TATAGCATTGTTATGAATTATTCATAAAATTATGTCCCACAGTATATAGTTTTGAAAAAACATATGATATACTACATCCAGTCTAACTTCTGTGGAAAGT
AGATCAGAAAAAATAAGATAGTCTTGAGAGAATTTTATTATAGAAGCTGTCTAATTTGACCTATTTTGCTTGCTCAGTGCTAAATCTATTGCTTTTTTTT
AATCTCCTGGCTTGAAATTATATTTACTTCAATAGGAAAGGTAAAAACATCAGTTTTTACTTTTCAAAGTTAATTTTCTGAAATAATTGCATTTTAATGA
GCACAAAATGGGTCATTTTATTTTTATTATACTCATCTTGTTTACACCTATACATAAACAGAAAACGTTAAAGAAGAGAAAAATAAAGGAGCTAAGTTCT
GCTGTTGAAGATTATTTCATCCAAGGCTTGGTTTTGAATAACTGAGGGAAATATCTCTAAATCTCAAGTTCATCAAAGCAGCTGCAATGGAATAAAATTG
CTATTTTATCGAGAAACCTGGTTTGGATGCTTATAAATTCCACTACTCTCAGCTTCATTTTCCTGAGTACGTGGTCACTGAAGCATCATTTAGACATTAC
ATAAACTGGCATGCAGATAAACCTATTTACATAGAGGGAGAAAACAGTTTCAATGTCTTGGACAATCTGTTATTTTAATGATTTACTTAAGAAAGAAACA
ATCTGAAAGCTTACCATAGCTTATCTTTTCTACTCACTTGGAGATTCAAGCTATTCAATGTGAGTTTTAAAAAGTTAAGCACAGTTAGTGAGTGAAATGG
TAGAATGTAGAACCTTTAAGCTTGCTGGTTGATAAACAGAATCAATCTTCCAGGACAGATAATTCCCTGAAGGGACCTATCCTTGCATAAGTGAACTAGT
TACTCATACAGAAAATGATCTGCACATCTTACTACAACACTACACACAAGAACTAAAAGATTAATGATTATCTGTATTCTCTTCACTAATTACTATTATG
GGGGAATAATGATTAGCAAATTATATGAATTCGAGTTCTCTCTATACTTTTATTAGTAAAGCTTATCATTTAATGGACTGAAGTAAGATGTGTTACCTTT
ATTCGAGCTATTTGTAGCCACACTAAATGAAGGTGTGTTTGAATATGGCGCATATATTTGCATATGTCCCATCATTTTCTTGTCATAATGGGGAATTCAG
GCTTAGCCAGTACTTCTATGGGATGAGACCTATAATCCCACCTATAGCAGCAAGTAACTACCCTTCATGATGATAGTGTACATGGAGCTGTGATTATGAA
CATGCTGCCTTTCCTGCTGCCATTGGCATTCTCTCTGTAAATTTTATTATGTGTGGTATCACACTCTCCAAAAATGCAGGGTATTTGGTTACATAACCAA
ACTAATTAAAGAATCAGTAATGAAATTGCAAAACCATGATCTTTTTTGAGCTAATGATTAGTTGGGCTTTCCTTTAAAATAATATAATCAGGCCGAGTGC
AGCGGCTCACACCTGTAATCTCGGCACTTTGGAAGTCCGCGGCGGGTGGTTCACCTGAGGTCGGGAGTTCAAGACCAGCCTGACCAACATGGAGAAACCC
CCATCTCTACTAAAAAAAAAATACAAAATTAGCCAGGCGTGATGGCGCATGCCTGTAATCCCAGCTACTCGGGAGACTGAGGCAGGAGAATCGCTTGAAC
CTGGGAGGCAGGGGTTGCAATGAGCCGAGATGTGCACTCCAGCCTGGGCAACAAAGAGCGAAACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAATCA
TATAATCAGTTCCCTTTTAAATAGAAAGAGGAGGAAAAAAAAAAGGAAAAGGGGGGGTATCTCATTTGTATACAAATAGATTTTCAATGGCATTTAATAA
AAGATTCTTTAATGGTTAAAATGATAAAGATTAATTCTACATATCTTGAAAAATCTTAATGACTTCTGTATTCTTGACTTCTTAAAAATATTTTCTTTCT
TTTAGTGTGCAATAAGACAAACTAAGGGGAATTTTTTCAGCTTGTATCTCTTTTACCCATATTATTTTCCTTGCATAAGCAAAAAAATAATAATTGCCTC
TAAAACTGATTTGACAGTGTTCAGTGACATCATTTAATATTGGTGATGGGGTGGAAGAGAAGGTAGGGAATGCCCTTATGGCCAAACCTAAAACACAGTT
TCCTTGAGCCTTCTGAGCAATCTTAGAATTATTCAGAAGCTTTCAGGAAACTCAAATTCTATTAATTTGATTTGGTTCCTTTCCAAAATGTTAATAGACA
TGTATTTGCTTAAAACGTCTACCTATTCCATTTAATTTCCTGCTGATAAATGTATTTTATCTACAAGCAAGTAGAATATTTTGTTTTGGTTAAAGTCAAG
TTTTTATAAAAGGAGGGGAAGTATAAGAGAGAGTTTCCTAGAGATACAATATCATCTCTGGAGCAAAATGTTGAGGCCAAGTGTAAAAACAGACTATTTC
TCTTTACTTCCTGCAGAATTTCATTTCAAGGGACCACAGCACACCCTTGAAAATTACCATTTATTTAATGCCAGTTGAACCAATGGGTAGCAAAAGAGGA
GGGAGGGAACATGGTCATAGAGACAAAATCTAACTACTATACCAGGTCTTCCTTTGTAAGAAATATTAGCCCTGCCAATATAAAACGCAGATGGACATAG
ACAGAATAAGCATCGAGGACTTTTTCTTATTTACTTGAAATCTAGAAGCTCAGTCATCTCTGCTCATCCCTGGACCCACTGGAGAGTTTTACTCACTAAC
AGGTCCTTTCCTGGAAGAAATAACCTCATCTCCTGCCATATTAGTTTACAATAAAAATCATTCCAAAGTGAGCCATTTCACATTGCATTTTTGCCACATG
CACATTTGCTATTGAAACCACAGATTCTCAGCATAAGTAAGACATAGGTGTTTCAGAAACTTCATAAATACACGATCTTTCAGGTGCTCCTCAATTTCTT
AATCAAGGTATATTGAACTCCAGTGATTAGGATAGAACCTGAAAACATCCTTTGTTCTATTGGATAGTACAACACAGCAAGAGCACACAGTTATTTGTAT
AATAAAACAACTTAATTAATGAGGAAGATGGGATGTTTGATTCCTGCTACCACCAGTTCACTTCACAAAGGCCTTCTTCTGGTATTACCAGGAAAACTTT
CCTGCATTTTCTAGGGAAAAAGAAAAGTCGTTTATTAGGAGCACAATGCAGATATGTATCTGTGTTTTCATAGCTTCAGCAAACTTCTTAGTAAAATTCC
CATTTCAACAAAAACCAAAATACTGATTGTTTGAATGTAGAAAGGTATAGAATAAAGACTACAAAGGGGAATTTTACCAGGGCTCCTTAGACCAGCTTCC
CCAGCATAATTTTTATATAACTCAAGTAAGCCTCTGCTTCCCCTCTCCTTTCCAGTATAATATAAGAAGGTCGGAACTGTCGCACAAAAGAACTTGATTT
CAATATGAAAATATAATATGTAATTTTGGGGACTGCAGACTTTCTGCATCAAAGATCTGGACAGCCTTAACTTTTATAAAAATAATTTTTCAATGTTCTC
TTTTACTAACCAGGAAAACAAGATGTTTTCTGAAATTAATGACTTTTTCTATTTTGGGTCTGTTTTCTAAGTTTTTACAGGTTGAGGTATAAAGGGTCGT
CTTCTCCTCATATTGCCTCTTCATAATCACCTGGGGCTATTTTTTGCAAGTCACTGCATTTTTACAAAAAATAAAAATAAAAAGTACATCTCACAAATCA
TAAAATTCTCCCTAGACTTCAGACAGTCCTTCTGGAGTGAAAGAATAGAAATACAGAAAGAAAAGAATTACAGGGTGGCTTTCTTTTTATTTTCCTATGG
TTAATGTACTGTATGGTATATATGTTTACAGAATGTATCTGCCTTGTGATGTTAACAAAATGAATGACAAAAAATAGTACTGATGTGCCATTTGACAGTT
TGCCTTAGCATCACTGTTTATGTTCTTCTTTTCTGTCCTTTTTGGTAAAAAAAAACGCAGGTTGTATTCCAAAGCTGTATTAACACAACATTCTCTTCCC
CACTCCTACCCAGCCTTCTTCAGAGCTGTGAATTTCATTACAGGAGCATTGAGGCAGAACCTTGCAGGTGTGGCCCAAAGGGGCTAAAGTGGGCATAGGT
TGGGATTTACTTCTGCCCGTCTACCAACCAAACACGTATCTGTGTTCTCATATAAGCCTGCAAAATTTTACACCCTGCCTTTCAGGGAGACAGGCCACAT
GGAGCGCATGACCTCTTGTAGTCGTCTCCTCACAGTCCTTCCCACTGTGAGAGAAGGAAACTTGCAGACCCCCAACTGGATCTGGGAGCATATTTTTAAG
CACAGTTGGCATTGCTTGAAAAAGCAAGAGAGATGGACTCAAATTCTATGATTGAGCCATGACTGAGGAATGTGCCCATTCGTTATAGTCGAAGATGAGT
AGGATGATATGGGTGAGAATAGGAGTGGCTGTAGAAATGGAATATTTTACAGTTATGTATTTTTTTAAGGAATAGTATTTTTATAATGAAATCTATATAC
ATTATGGAGCTTGAGTTGGAAAACACCCTTGACTGAGCTATTTCTTCATTCCATTAAAGGTAACTTTCTGGGGAGTCCTATAGCACTAGGCCAAGCCTTG
GGGGCATGAACAAAGGGCCTGTCACTTGGCCTTGCACTGCCATTACATGAGATCCAGTGTTTCCAAATAGGCCTTGGTTGGAAGATTGAGCTTTCTATAC
CTGCCATTAGGTAGATTAGATAGATGGCTTGATAGCTCTCTGGGCTATACTTTTAATAATATATAATAATCTTTGGGAAGGAGATAGCTATTTTAAATGC
AAGCAAAGCCCAGAAACTATCAAAGTCCAAATCTTTCACATATTTAAGGAGTAATTGCCACATTTGAGGTTAAGGGACCACTTACTATGGTGCATTTGAG
AAATATATATGAAACGGTGAGTCAGAGCCCTCTGACCATCTTCAGTCTACACATAAGCAGATAAACCACCAATATAAATCTTATAGGGGCCAGACGAGGT
GGCTTATGCCTGTAATCCCAGCACTTTGGGGGGCCAAGGCAGGAGGATAGTGTGAGCCCAGAAGTTCAAGACCAGGCTAGGCAACATGTTGAGACCATGT
TGTTTAGTCTCTACTAAAAAATATAAAAATTAGCCAGCATGGTGGCACACACCTGTAGTCCCAGCTACTTGGGAGACTGAGGCAGGAGGATCACTTGAGC
CCAGGAGGTGGAGGCTGCAGGGGGCTGAGATCTCACCACTCCATTCCAGCCTGGGCAACAGAGCAAGACTCTGTCTCAAAAAAAAAAACAAAAAAACAAT
TATCAGTTGGCCTTCTACATAACACAGGGCTACACTGTATTTTTAGAGTTAAGTAGATACAGGAAAAGATTGTCTTTATCCATAAAGGAGATTCTGAATT
TTTAGAGTTCCTGAATATTTTCCCCCAAGTTTCTGTCAAATTCCTGAAGTCCCTTCCCTATCACACTCAGTTTCCTGAAGCTCTTCCCCTACACCTGCTC
CTCTGTCTGGCTAACAGAGTTGTCATGTCTCAGAAACTACTCACCACTCTTGTGAGACTCTCTTCCCAAGCATCATCCTTCCTCAGGATGAGGCCTTTTT
CTACTACCCAAGAGATCAAGACCCTTTTTCTAACAAGACAAGGTTATATCTACTCCATTTTCAAGAGAAATAACCCCTCTGGTTCCCATGCAAATCGCTT
AAATTCCTTCATCACCAGAATCTCTCCAACAGGCCCAACTCCAGCCCAGCTGTGAACACTGCTGTCATGGAGACAACTCCAAAATGAAAGAACTATGCAA
TTGCCTGAAGGTGCTAATGGAGAGCCAGTTTACTCTAATCTCTTATTACTAAGGAACCTCTCGGTTTCGAGATTAAGTGGGCAGGGAGACATCCAGTCAC
TTAGTTTTGCAATGACAGGTCTTGATATACACAGAGGCCACCAGGCAATGCCTGATCCAAACTATTCTGTATGTAGCTCCAACTCCAATTCTGTGATATC
CTATTCTGGCAGGTGGGAAGAGTTCTATTCTTTGCAGGGTTCTGGAACATTCTTTCCTGCTCTCAAGCTCCTGACTTAGGAGAGTCAAAATCATACAGGG
GTTCCAGAAAATGTTGTGTCTGATGCAGCTTCTCAGTGAATGTAGGTTGTTGGTGAAATTTTCAGCTTTAGCATCTCACTCGGGGTGAGTGATGTCTCTG
TAAATACTTTCATTTGTGGTTGGTTGGTGGGGGTGGGGGTGGGAGCCTGTCGTGCTTACTCTGAATTAGCTTACTGGGCTAGCTGCTGTACTTTGTAACC
TGAAGTGTACTTTGACTGTTCTGTTTCCTTCAGATGAAAAACAAAATAAAAACCGACTTCAGAAAAGACACTACCAGCGACAGCTGATGCTGTACTTGTA
GCTTCTCTCTGTTCCTCTGTACAGTATTAATAGACAATAAACTGCCTTTTCACTGCATCTA
  • refseq_PALM2.F1 (forward primer)
  • refseq_PALM2.R1 (reverse primer)
  • Single exon skipping

Frame 0

TRLRERRAAPVSPAAAHPAAEPRDGDGRGGIAQ
GKAASHSRKKKEAD*NRRQATTA*RADTSAAAFQ
VQSASGEMAAAGHTRWNCRRGGSQEAAV*RG*V
QSQAT*R*HSEAGARNTNARK*RVPDICQRANH
PRETEGNRKILQGLSEGFLQYGWSCVRHGN*CGE
RQTNRRDQDSLYIYHWPRGGPSERSQSL**WYQ
SSV*GA
LRRHRSRKWSAQIKHKGCRRAYSEGWT
IKLRRRARV*KDCDCRWEPQPSQGTHALQRS*VR
NGT*V*ERPFFREPRAAGPSPQRCRAGGKLGSA
RHHDFYGLPKYRG*RGDEKGARL**NHQG*IGP
H**R**EVIEGEDSDGRVHY*RERG*ACVREAGL
RHHRALIPRREGREPSYRASPRYPKEKALSMLC
CHVTTSFFSFLLGSLYSPPLT*TSLYH*LQYCE
LEANTCLALQLNCFDLSHFFSFSSPERQRACVCF
ILSKNLLFL*TFPCVFKSESLPSCSIGMDSSYQ
PVIW*P*LT*LELNPLALGVSFCSVFL*RSHTL
PCLWFLTCLLCCGSLFLYLVWQNAVGSSRLLV*P
KVDLT*SVRSRVMLFAALHKLPDYSIVHSWLSF
C*N*NEVNVEEPRACHS*NVGTDSITCPSAVVS
LSMV*PMNPLYKKHHFKISKDMKQTLFEASVAID
LQT*ANSQALFLFS*KNVNFYIVSFFWIFSGHV
NLFSMRRSS*EVSLQ*PYF*NSLSNLQWLP*CS
HFIMDGAVMH*LFISSPVDYKALHPYSFLSGPMR
KRMF*VTSTCRFICPSKKKTLKNF*KLRKTYLL
NVKHLIS*QILSGT*LSFLGHCFVFSFWRFQKS
KEYFLSRTQ*TVFEIPSQHSPKAKSHICSKTKGK
QFNKITIV***NKDIT*LLVLIRVILTLSYLPI
YSIVMNYS*NYVPQYIVLKKHMIYYIQSNFCGK
*IRKNKIVLREFYYRSCLI*PILLAQC*IYCFFL
ISWLEIIFTSIGKVKTSVFTFQS*FSEIIAF**
AQNGSFYFYYTHLVYTYT*TENVKEEKNKGAKF
CC*RLFHPRLGFE*LREISLNLKFIKAAAME*NC
YFIEKPGLDAYKFHYSQLHFPEYVVTEASFRHY
INWHADKPIYIEGENSFNVLDNLLF**FT*ERN
NLKAYHSLSFLLTWRFKLFNVSFKKLSTVSE*NG
RM*NL*ACWLINRINLPGQIIP*RDLSLHK*TS
YSYRK*SAHLTTTLHTRTKRLMIICILFTNYYY
GGIMISKLYEFEFSLYFY**SLSFNGLK*DVLPL
FELFVATLNEGVFEYGAYICICPIIFLS*WGIQ
A*PVLLWDETYNPTYSSK*LPFMMIVYMEL*L*
TCCLSCCHWHSLCKFYYVWYHTLQKCRVFGYITK
LIKESVMKLQNHDLF*AND*LGFPLK*YNQAEC
SGSHL*SRHFGSPRRVVHLRSGVQDQPDQHGET
PISTKKKIQN*PGVMAHACNPSYSGD*GRRIA*T
WEAGVAMSRDVHSSLGNKERNSISKKKKKKKKS
YNQFPFK*KEEEKKKEKGGYLICIQIDFQWHLI
KDSLMVKMIKINSTYLEKS**LLYS*LLKNIFFL
LVCNKTN*GEFFQLVSLLPILFSLHKQKNNNCL
*N*FDSVQ*HHLILVMGWKRR*GMPLWPNLKHS
FLEPSEQS*NYSEAFRKLKFY*FDLVPFQNVNRH
VFA*NVYLFHLISC**MYFIYKQVEYFVLVKVK
FL*KEGKYKREFPRDTISSLEQNVEAKCKNRLF
LFTSCRISFQGTTAHP*KLPFI*CQLNQWVAKEE
GGNMVIETKSNYYTRSSFVRNISPANIKRRWT*
TE*ASRTFSYLLEI*KLSHLCSSLDPLESFTH*
QVLSWKK*PHLLPY*FTIKIIPK*AISHCIFATC
TFAIETTDSQHK*DIGVSETS*IHDLSGAPQFL
NQGILNSSD*DRT*KHPLFYWIVQHSKSTQLFV
**NNLINEEDGMFDSCYHQFTSQRPSSGITRKTF
LHFLGKKKSRLLGAQCRYVSVFS*LQQTS**NS
HFNKNQNTDCLNVERYRIKTTKGNFTRAP*TSF
PSIIFI*LK*ASASPLLSSII*EGRNCRTKELDF
NMKI*YVILGTADFLHQRSGQP*LL*K*FFNVL
FY*PGKQDVF*N**LFLFWVCFLSFYRLRYKGS
SSPHIASS*SPGAIFCKSLHFYKK*K*KVHLTNH
KILPRLQTVLLE*KNRNTERKELQGGFLFIFLW
LMYCMVYMFTECICLVMLTK*MTKNSTDVPFDS
LP*HHCLCSSFLSFLVKKNAGCIPKLY*HNILFP
TPTQPSSEL*ISLQEH*GRTLQVWPKGAKVGIG
WDLLLPVYQPNTYLCSHISLQNFTPCLSGRQAT
WSA*PLVVVSSQSFPL*EKETCRPPTGSGSIFLS
TVGIA*KSKRDGLKFYD*AMTEECAHSL*SKMS
RMIWVRIGVAVEMEYFTVMYFFKE*YFYNEIYI
HYGA*VGKHP*LSYFFIPLKVTFWGVL*H*AKPW
GHEQRACHLALHCHYMRSSVSK*ALVGRLSFLY
LPLGRLDRWLDSSLGYTFNNI**SLGRR*LF*M
QAKPRNYQSPNLSHI*GVIATFEVKGPLTMVHLR
NIYETVSQSPLTIFSLHISR*TTNINLIGARRG
GLCL*SQHFGGPRQEDSVSPEVQDQARQHVETM
LFSLY*KI*KLASMVAHTCSPSYLGD*GRRIT*A
QEVEAAGG*DLTTPFQPGQQSKTLSQKKKQKNN
YQLAFYITQGYTVFLELSRYRKRLSLSIKEILN
F*SS*IFSPKFLSNS*SPFPITLSFLKLFPYTCS
SVWLTELSCLRNYSPLL*DSLPKHHPSSG*GLF
LLPKRSRPFF*QDKVISTPFSREITPLVPMQIA
*IPSSPESLQQAQLQPSCEHCCHGDNSKMKELCN
CLKVLMESQFTLISYY*GTSRFRD*VGRETSSH
LVLQ*QVLIYTEATRQCLIQTILYVAPTPIL*Y
PILAGGKSSILCRVLEHSFLLSSS*LRRVKIIQG
FQKMLCLMQLLSECRLLVKFSALASHSG*VMSL
*ILSFVVGWWGWGWEPVVLTLN*LTGLAAVLCN
LKCTLTVLFPSDEKQNKNRLQKRHYQRQLMLYL*
LLSVPLYSINRQ*TAFSLHL

Frame 1

LGSGRGEQRR*APQQRTRPRSPAMEMAEAELHK
ERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHS
KSKVLREKWLLQGIPAGTAEEEEARRRQSEEDEF
RVKQLEDNIQRLEQEIQTLESEESQISAKEQII
LEKLKETEKSFKDFQKGFSSTDGAVYAMEINVE
KDKQTGETKILSTSTIGPEGVHQKGVKVYDDGTK
VVYEVR
SGGTVVENGVHKLSTKDVEELIQKAGQ
SSLGGGHVSERTVIADGSLSHPKEHMLCKEAKL
EMVHKSRKDHSSGNPGQQAQAPSAAGPEANLDQP
VTMIFMGYQNIEDEEETKKVLGYDETIKAELVL
IDEDDEKSLREKTVTDVSTIDGNAAELVSGRPV
SDTTEPSSPEGKEESLATEPAPGTQKKKRCQCCV
VM*PLLSSPFFWAACTLHHSRRPHCTTNCNTVN
WKQTPALPCS*IALISLIFFPFPHLRDNVHVCA
SFSPRTCFSSKPFLVSSRVNHFLPARLEWTLRIS
Q*YGSLNSLDWN*THWHWGFHFVVCSCNVVTHC
HVSGFSLASFAVDLCFYILCGKMLLALAGC*CS
QKWTLLSLSDLG*CFLLPYISFQITVLCIHGFLS
VKTEMKSM*KNPELVTAEM*GLIP*PAHQRLSL
FLWFNR*TLYIRSTILKFLRT*NKHCLKHQ*QL
ISKLRQIHKPCFYSLKKM*IFILFLFSGYFLVML
IYFQ*GDHLEKYLCSDHISKTVCPTYNGCHDAP
TSSWMVL*CINCSSPPQLITKPCIHTLFFLAP*
ERECFR*LQLVGLSALQKKKL*KTFKN*ERPIFS
MLST*FHNKY*VAHS*AS*GIVLFLASGDSRRA
KNIFYLEHNEQFLKYLLSTPPKQKATYVVKPKG
NNLIK*Q*YSNEIKI*HDYWF**ELS*L*VICPF
IALL*IIHKIMSHSI*F*KNI*YTTSSLTSVES
RSEKIR*S*ENFIIEAV*FDLFCLLSAKSIAFF
*SPGLKLYLLQ*ER*KHQFLLFKVNFLK*LHFNE
HKMGHFIFIILILFTPIHKQKTLKKRKIKELSS
AVEDYFIQGLVLNN*GKYL*ISSSSKQLQWNKI
AILSRNLVWMLINSTTLSFIFLSTWSLKHHLDIT
*TGMQINLFT*REKTVSMSWTICYFNDLLKKET
I*KLTIAYLFYSLGDSSYSM*VLKS*AQLVSEM
VECRTFKLAG**TESIFQDR*FPEGTYPCISELV
THTENDLHILLQHYTQELKD**LSVFSSLITIM
GE**LANYMNSSSLYTFISKAYHLMD*SKMCYL
YSSYL*PH*MKVCLNMAHIFAYVPSFSCHNGEFR
LSQYFYGMRPIIPPIAASNYPS***CTWSCDYE
HAAFPAAIGILSVNFIMCGITLSKNAGYLVT*P
N*LKNQ**NCKTMIFFELMISWAFL*NNIIRPSA
AAHTCNLGTLEVRGGWFT*GREFKTSLTNMEKP
PSLLKKKYKISQA*WRMPVIPATRETEAGESLE
PGRQGLQ*AEMCTPAWATKSETPSQKKKKKKKNH
IISSLLNRKRRKKKRKRGGISFVYK*IFNGI**
KIL*WLK**RLILHILKNLNDFCILDFLKIFSF
F*CAIRQTKGNFFSLYLFYPYYFPCISKKIIIAS
KTDLTVFSDII*YW*WGGREGRECPYGQT*NTV
SLSLLSNLRIIQKLSGNSNSINLIWFLSKMLID
MYLLKTSTYSI*FPADKCILSTSK*NILFWLKSS
FYKRRGSIRESFLEIQYHLWSKMLRPSVKTDYF
SLLPAEFHFKGPQHTLENYHLFNAS*TNG*QKR
REGTWS*RQNLTTIPGLPL*EILALPI*NADGHR
QNKHRGLFLIYLKSRSSVISAHPWTHWRVLLTN
RSFPGRNNLISCHISLQ*KSFQSEPFHIAFLPH
AHLLLKPQILSISKT*VFQKLHKYTIFQVLLNFL
IKVY*TPVIRIEPENILCSIG*YNTARAHSYLY
NKTT*LMRKMGCLIPATTSSLHKGLLLVLPGKL
SCIF*GKRKVVY*EHNADMYLCFHSFSKLLSKIP
ISTKTKILIV*M*KGIE*RLQRGILPGLLRPAS
PA*FLYNSSKPLLPLSFPV*YKKVGTVAQKNLI
SI*KYNM*FWGLQTFCIKDLDSLNFYKNNFSMFS
FTNQENKMFSEINDFFYFGSVF*VFTG*GIKGR
LLLILPLHNHLGLFFASHCIFTKNKNKKYISQI
IKFSLDFRQSFWSERIEIQKEKNYRVAFFLFSYG
*CTVWYICLQNVSAL*C*QNE*QKIVLMCHLTV
CLSITVYVLLFCPFW*KKTQVVFQSCINTTFSS
PLLPSLLQSCEFHYRSIEAEPCRCGPKGLKWA*V
GIYFCPSTNQTRICVLI*ACKILHPAFQGDRPH
GAHDLL*SSPHSPSHCERRKLADPQLDLGAYF*
AQLALLEKAREMDSNSMIEP*LRNVPIRYSRR*V
G*YG*E*EWL*KWNILQLCIFLRNSIFIMKSIY
IMELELENTLD*AISSFH*R*LSGESYSTRPSL
GGMNKGPVTWPCTAIT*DPVFPNRPWLED*AFYT
CH*VD*IDGLIALWAILLIIYNNLWEGDSYFKC
KQSPETIKVQIFHIFKE*LPHLRLRDHLLWCI*
EIYMKR*VRAL*PSSVYT*ADKPPI*IL*GPDEV
AYACNPSTLGGQGRRIV*AQKFKTRLGNMLRPC
CLVSTKKYKN*PAWWHTPVVPATWETEAGGSLE
PRRWRLQGAEISPLHSSLGNRARLCLKKKNKKTI
ISWPST*HRATLYF*S*VDTGKDCLYP*RRF*I
FRVPEYFPPSFCQIPEVPSLSHSVS*SSSPTPA
PLSG*QSCHVSETTHHSCETLFPSIILPQDEAFF
YYPRDQDPFSNKTRLYLLHFQEK*PLWFPCKSL
KFLHHQNLSNRPNSSPAVNTAVMETTPK*KNYA
IA*RC*WRASLL*SLITKEPLGFEIKWAGRHPVT
*FCNDRS*YTQRPPGNA*SKLFCM*LQLQFCDI
LFWQVGRVLFFAGFWNILSCSQAPDLGESKSYR
GSRKCCV*CSFSVNVGCW*NFQL*HLTRGE*CLC
KYFHLWLVGGGGGGSLSCLL*ISLLG*LLYFVT
*SVL*LFCFLQMKNKIKTDFRKDTTSDS*CCTC
SFSLFLCTVLIDNKLPFHCI

Frame 2

SAPGEASSAGEPRSSAPGRGAPRWRWQRRNCTR
KGCKP*QKKERGRLK*KASDNSLTSRYFCCSIP
SPKCFGRNGCCRAYPLELPKRRKPGGGSLKRMS
SESSNLKITFRGWSKKYKR*KVKSPRYLPKSKSS
*RN*RKQKNPSRTFRRVSPVRMELCTPWKLMWR
KTNKQERPRFSLHLPLAQRGSIRKESKSMMMVP
K*CMRC
AQEAP**KMECTN*AQRM*KSLFRRLDN
QA*EEGTCLKGL*LQMGASAIPRNTCSAKKLS*
KWYISLGKTILPGTQGSRPKPPALQGRRQTWIS
PSP*FLWATKISRMKRRRKRC*AMMKPSRLNWSS
LMKMMRSH*GRRQ*RTCPLLTGTRLSLCPGGRS
QTPQSPHPQKGRKRA*LQSQPQVPKRKSAVNAV
LSCDHFFLLLSSGQPVLSTTHVDLTVPLTAIL*T
GSKHLPCLAVELL*SLSFFFLFLT*ETTCMCVL
HSLQELAFPLNLSLCLQE*ITSFLLDWNGLFVS
ASDMVALTHLTGIEPIGTGGFIL*CVPVT*SHTA
MSLVSHLPPLLWIFVFISCVAKCCWL*PVASVA
KSGPYLVCPI*GDAFCCLT*ASRLQYCAFMAFF
LLKLK*SQCRRTQSLSQLKCRD*FHNLPISGCLS
FYGLTDEPFI*EAPF*NF*GHETNIV*SISSN*
SPNLGKFTSLVSILLKKCKFLYCFFFLDIFWSC
*SIFNEEIILRSIFAVTIFLKQSVQPTMVAMMLP
LHHGWCCNALTVHLLPS*LQSLASILFSFWPHE
KENVLGNFNL*VYLPFKKKNFKKLLKIKKDLSS
QC*ALNFITNIKWHIAELLRALFCF*LLEIPEEQ
RIFFI*NTMNSF*NTFSALPQSKKPHM**NQRE
TI**NNNSIVMK*RYNMITGFNKSYLNFKLFAH
L*HCYELFIKLCPTVYSFEKTYDILHPV*LLWKV
DQKK*DSLERILL*KLSNLTYFACSVLNLLLFF
NLLA*NYIYFNRKGKNISFYFSKLIF*NNCILM
STKWVILFLLYSSCLHLYINRKR*RREK*RS*VL
LLKIISSKAWF*ITEGNISKSQVHQSSCNGIKL
LFYRETWFGCL*IPLLSASFS*VRGH*SII*TL
HKLACR*TYLHRGRKQFQCLGQSVILMIYLRKKQ
SESLP*LIFSTHLEIQAIQCEF*KVKHS**VKW
*NVEPLSLLVDKQNQSSRTDNSLKGPILA*VN*
LLIQKMICTSYYNTTHKN*KINDYLYSLH*LLLW
GNND*QII*IRVLSILLLVKLII*WTEVRCVTF
IRAICSHTK*RCV*IWRIYLHMSHHFLVIMGNS
GLASTSMG*DL*SHL*QQVTTLHDDSVHGAVIMN
MLPFLLPLAFSL*ILLCVVSHSPKMQGIWLHNQ
TN*RISNEIAKP*SFLS**LVGLSFKII*SGRV
QRLTPVISALWKSAAGGSPEVGSSRPA*PTWRNP
HLY*KKNTKLARRDGACL*SQLLGRLRQENRLN
LGGRGCNEPRCALQPGQQRAKLHLKKKKKKKKI
I*SVPF*IERGGKKKGKGGVSHLYTNRFSMAFNK
RFFNG*NDKD*FYIS*KILMTSVFLTS*KYFLS
FSVQ*DKLRGIFSACISFTHIIFLA*AKK**LP
LKLI*QCSVTSFNIGDGVEEKVGNALMAKPKTQF
P*AF*AILELFRSFQETQILLI*FGSFPKC**T
CICLKRLPIPFNFLLINVFYLQASRIFCFG*SQ
VFIKGGEV*ERVS*RYNIISGAKC*GQV*KQTIS
LYFLQNFISRDHSTPLKITIYLMPVEPMGSKRG
GREHGHRDKI*LLYQVFLCKKY*PCQYKTQMDI
DRISIEDFFLFT*NLEAQSSLLIPGPTGEFYSLT
GPFLEEITSSPAILVYNKNHSKVSHFTLHFCHM
HICY*NHRFSA*VRHRCFRNFINTRSFRCSSIS
*SRYIELQ*LG*NLKTSFVLLDSTTQQEHTVICI
IKQLN**GRWDV*FLLPPVHFTKAFFWYYQENF
PAFSREKEKSFIRSTMQICICVFIASANFLVKF
PFQQKPKY*LFECRKV*NKDYKGEFYQGSLDQLP
QHNFYITQVSLCFPSPFQYNIRRSELSHKRT*F
QYENIICNFGDCRLSASKIWTALTFIKIIFQCS
LLLTRKTRCFLKLMTFSILGLFSKFLQVEV*RVV
FSSYCLFIITWGYFLQVTAFLQKIKIKSTSHKS
*NSP*TSDSPSGVKE*KYRKKRITGWLSFYFPM
VNVLYGIYVYRMYLPCDVNKMNDKK*Y*CAI*QF
ALASLFMFFFSVLFGKKKRRLYSKAVLTQHSLP
HSYPAFFRAVNFITGALRQNLAGVAQRG*SGHR
LGFTSARLPTKHVSVFSYKPAKFYTLPFRETGHM
ERMTSCSRLLTVLPTVREGNLQTPNWIWEHIFK
HSWHCLKKQERWTQIL*LSHD*GMCPFVIVEDE
*DDMGENRSGCRNGIFYSYVFF*GIVFL**NLYT
LWSLSWKTPLTELFLHSIKGNFLGSPIALGQAL
GA*TKGLSLGLALPLHEIQCFQIGLGWKIELSI
PAIR*IR*MA**LSGLYF**YIIIFGKEIAILNA
SKAQKLSKSKSFTYLRSNCHI*G*GTTYYGAFE
KYI*NGESEPSDHLQSTHKQINHQYKSYRGQTR
WLMPVIPALWGAKAGG*CEPRSSRPG*ATC*DHV
V*SLLKNIKISQHGGTHL*SQLLGRLRQEDHLS
PGGGGCRGLRSHHSIPAWATEQDSVSKKKTKKQ
LSVGLLHNTGLHCIFRVK*IQEKIVFIHKGDSEF
LEFLNIFPQVSVKFLKSLPYHTQFPEALPLHLL
LCLANRVVMSQKLLTTLVRLSSQASSFLRMRPF
STTQEIKTLFLTRQGYIYSIFKRNNPSGSHANRL
NSFITRISPTGPTPAQL*TLLSWRQLQNERTMQ
LPEGANGEPVYSNLLLLRNLSVSRLSGQGDIQS
LSFAMTGLDIHRGHQAMPDPNYSVCSSNSNSVIS
YSGRWEEFYSLQGSGTFFPALKLLT*ESQNHTG
VPENVVSDAASQ*M*VVGEIFSFSISLGVSDVS
VNTFICGWLVGVGVGACRAYSELAYWASCCTL*P
EVYFDCSVSFR*KTK*KPTSEKTLPATADAVLV
ASLCSSVQY**TINCLFTAS

Sequence NM_053016

ACTCGGCTCCGGGAGAGGCGAGCAGCGCCGGTGAGCCCCGCAGCAGCGCACCCGGCCGCGGAGCCCCGCGATGGAGATGGCAGAGGCGGAATTGCACAAG
GAAAGGCTGCAAGCCATAGCAGAAAAAAGAAAGAGGCAGACTGAAATAGAAGGCAAGCGACAACAGCTTGACGAGCAGATACTTCTGCTGCAGCATTCCA
AGTCCAAAGTGCTTCGGGAGAAATGGCTGCTGCAGGGCATACCCGCTGGAACTGCCGAAGAGGAGGAAGCCAGGAGGCGGCAGTCTGAAGAGGATGAGTT
CAGAGTCAAGCAACTTGAAGATAACATTCAGAGGCTGGAGCAAGAAATACAAACGCTAGAAAGTGAAGAGTCCCAGATATCTGCCAAAGAGCAAATCATC
CTAGAGAAACTGAAGGAAACAGAAAAATCCTTCAAGGACTTTCAGAAGGGTTTCTCCAGTACGGATGGAGATGCAGTAAATTACATTTCCTCCCAGCTTC
CCGACCTGCCAATCCTCTGTTCACGAACAGCAGAACCATCACCTGGGCAGGACGGGACCAGCAGAGCGGCTG
CTGTGTACGCCATGGAAATTAATGTGGA
GAAAGACAAACAAACAGGAGAGACCAAGATTCTCTCTACATCTACCATTGGCCCAGAGGGGGTCCATCAGAAAGGAGTCAAAGTCTATGATGATGGTACC
AAAGTAGTGTATGAGGTGCG
CTCAGGAGGCACCGTAGTAGAAAATGGAGTGCACAAATTAAGCACAAAGGATGTAGAAGAGCTTATTCAGAAGGCTGGAC
AATCAAGCTTAGGAGGAGGGCACGTGTCTGAAAGGACTGTGATTGCAGATGGGAGCCTCAGCCATCCCAAGGAACACATGCTCTGCAAAGAAGCTAAGTT
AGAAATGGTACATAAGTCTAGGAAAGACCATTCTTCCGGGAACCCAGGGCAGCAGGCCCAAGCCCCCAGCGCTGCAGGGCCGGAGGCAAACTTGGATCAG
CCCGTCACCATGATTTTTATGGGCTACCAAAATATCGAGGATGAAGAGGAGACGAAAAAGGTGCTAGGCTATGATGAAACCATCAAGGCTGAATTGGTCC
TCATTGATGAAGATGATGAGAAGTCATTGAGGGAGAAGACAGTGACGGACGTGTCCACTATTGACGGGAACGCGGCTGAGCTTGTGTCCGGGAGGCCGGT
CTCAGACACCACAGAGCCCTCATCCCCAGAAGGGAAGGAAGAGAGCCTAGCTACAGAGCCAGCCCCAGGTACCCAAAAGAAAAAGCGCTGTCAATGCTGT
GTTGTCATGTGACCACTTCTTTCTTCTCCTTTCTTCTGGGCAGCCTGTACTCTCCACCACTCACGTAGACCTCACTGTACCACTAACTGCAATACTGTGA
ACTGGAAGCAAACACCTGCCTTGCCTTGCAGTTGAATTGCTTTGATCTCTCTCATTTTTTTTCCTTTTCCTCACCTGAGAGACAACGTGCATGTGTGTGC
TTCATTCTCTCCAAGAACTTGCTTTTCCTCTAAACCTTTCCTTGTGTCTTCAAGAGTGAATCACTTCCTTCCTGCTCGATTGGAATGGACTCTTCGTATC
AGCCAGTGATATGGTAGCCTTAACTCACTTGACTGGAATTGAACCCATTGGCACTGGGGGTTTCATTTTGTAGTGTGTTCCTGTAACGTAGTCACACACT
GCCATGTCTCTGGTTTCTCACTTGCCTCCTTTGCTGTGGATCTTTGTTTTTATATCTTGTGTGGCAAAATGCTGTTGGCTCTAGCCGGTTGCTAGTGTAG
CCAAAAGTGGACCTTACTTAGTCTGTCCGATCTAGGGTGATGCTTTTTGCTGCCTTACATAAGCTTCCAGATTACAGTATTGTGCATTCATGGCTTTCTT
TCTGTTAAAACTGAAATGAAGTCAATGTAGAAGAACCCAGAGCTTGTCACAGCTGAAATGTAGGGACTGATTCCATAACCTGCCCATCAGCGGTTGTCTC
TCTTTCTATGGTTTAACCGATGAACCCTTTATATAAGAAGCACCATTTTAAAATTTCTAAGGACATGAAACAAACATTGTTTGAAGCATCAGTAGCAATT
GATCTCCAAACTTAGGCAAATTCACAAGCCTTGTTTCTATTCTCTTAAAAAAATGTAAATTTTTATATTGTTTCTTTTTTCTGGATATTTTCTGGTCATG
TTAATCTATTTTCAATGAGGAGATCATCTTGAGAAGTATCTTTGCAGTGACCATATTTCTAAAACAGTCTGTCCAACCTACAATGGTTGCCATGATGCTC
CCACTTCATCATGGATGGTGCTGTAATGCATTAACTGTTCATCTCCTCCCCAGTTGATTACAAAGCCTTGCATCCATACTCTTTTCTTTCTGGCCCCATG
AGAAAGAGAATGTTTTAGGTAACTTCAACTTGTAGGTTTATCTGCCCTTCAAAAAAAAAAACTTTAAAAAACTTTTAAAAATTAAGAAAGACCTATCTTC
TCAATGTTAAGCACTTAATTTCATAACAAATATTAAGTGGCACATAGCTGAGCTTCTTAGGGCATTGTTTTGTTTTTAGCTTCTGGAGATTCCAGAAGAG
CAAAGAATATTTTTTATCTAGAACACAATGAACAGTTTTTGAAATACCTTCTCAGCACTCCCCCAAAGCAAAAAGCCACATATGTAGTAAAACCAAAGGG
AAACAATTTAATAAAATAACAATAGTATAGTAATGAAATAAAGATATAACATGATTACTGGTTTTAATAAGAGTTATCTTAACTTTAAGTTATTTGCCCA
TTTATAGCATTGTTATGAATTATTCATAAAATTATGTCCCACAGTATATAGTTTTGAAAAAACATATGATATACTACATCCAGTCTAACTTCTGTGGAAA
GTAGATCAGAAAAAATAAGATAGTCTTGAGAGAATTTTATTATAGAAGCTGTCTAATTTGACCTATTTTGCTTGCTCAGTGCTAAATCTATTGCTTTTTT
TTAATCTCCTGGCTTGAAATTATATTTACTTCAATAGGAAAGGTAAAAACATCAGTTTTTACTTTTCAAAGTTAATTTTCTGAAATAATTGCATTTTAAT
GAGCACAAAATGGGTCATTTTATTTTTATTATACTCATCTTGTTTACACCTATACATAAACAGAAAACGTTAAAGAAGAGAAAAATAAAGGAGCTAAGTT
CTGCTGTTGAAGATTATTTCATCCAAGGCTTGGTTTTGAATAACTGAGGGAAATATCTCTAAATCTCAAGTTCATCAAAGCAGCTGCAATGGAATAAAAT
TGCTATTTTATCGAGAAACCTGGTTTGGATGCTTATAAATTCCACTACTCTCAGCTTCATTTTCCTGAGTACGTGGTCACTGAAGCATCATTTAGACATT
ACATAAACTGGCATGCAGATAAACCTATTTACATAGAGGGAGAAAACAGTTTCAATGTCTTGGACAATCTGTTATTTTAATGATTTACTTAAGAAAGAAA
CAATCTGAAAGCTTACCATAGCTTATCTTTTCTACTCACTTGGAGATTCAAGCTATTCAATGTGAGTTTTAAAAAGTTAAGCACAGTTAGTGAGTGAAAT
GGTAGAATGTAGAACCTTTAAGCTTGCTGGTTGATAAACAGAATCAATCTTCCAGGACAGATAATTCCCTGAAGGGACCTATCCTTGCATAAGTGAACTA
GTTACTCATACAGAAAATGATCTGCACATCTTACTACAACACTACACACAAGAACTAAAAGATTAATGATTATCTGTATTCTCTTCACTAATTACTATTA
TGGGGGAATAATGATTAGCAAATTATATGAATTCGAGTTCTCTCTATACTTTTATTAGTAAAGCTTATCATTTAATGGACTGAAGTAAGATGTGTTACCT
TTATTCGAGCTATTTGTAGCCACACTAAATGAAGGTGTGTTTGAATATGGCGCATATATTTGCATATGTCCCATCATTTTCTTGTCATAATGGGGAATTC
AGGCTTAGCCAGTACTTCTATGGGATGAGACCTATAATCCCACCTATAGCAGCAAGTAACTACCCTTCATGATGATAGTGTACATGGAGCTGTGATTATG
AACATGCTGCCTTTCCTGCTGCCATTGGCATTCTCTCTGTAAATTTTATTATGTGTGGTATCACACTCTCCAAAAATGCAGGGTATTTGGTTACATAACC
AAACTAATTAAAGAATCAGTAATGAAATTGCAAAACCATGATCTTTTTTGAGCTAATGATTAGTTGGGCTTTCCTTTAAAATAATATAATCAGGCCGAGT
GCAGCGGCTCACACCTGTAATCTCGGCACTTTGGAAGTCCGCGGCGGGTGGTTCACCTGAGGTCGGGAGTTCAAGACCAGCCTGACCAACATGGAGAAAC
CCCCATCTCTACTAAAAAAAAAATACAAAATTAGCCAGGCGTGATGGCGCATGCCTGTAATCCCAGCTACTCGGGAGACTGAGGCAGGAGAATCGCTTGA
ACCTGGGAGGCAGGGGTTGCAATGAGCCGAGATGTGCACTCCAGCCTGGGCAACAAAGAGCGAAACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAAT
CATATAATCAGTTCCCTTTTAAATAGAAAGAGGAGGAAAAAAAAAAGGAAAAGGGGGGGTATCTCATTTGTATACAAATAGATTTTCAATGGCATTTAAT
AAAAGATTCTTTAATGGTTAAAATGATAAAGATTAATTCTACATATCTTGAAAAATCTTAATGACTTCTGTATTCTTGACTTCTTAAAAATATTTTCTTT
CTTTTAGTGTGCAATAAGACAAACTAAGGGGAATTTTTTCAGCTTGTATCTCTTTTACCCATATTATTTTCCTTGCATAAGCAAAAAAATAATAATTGCC
TCTAAAACTGATTTGACAGTGTTCAGTGACATCATTTAATATTGGTGATGGGGTGGAAGAGAAGGTAGGGAATGCCCTTATGGCCAAACCTAAAACACAG
TTTCCTTGAGCCTTCTGAGCAATCTTAGAATTATTCAGAAGCTTTCAGGAAACTCAAATTCTATTAATTTGATTTGGTTCCTTTCCAAAATGTTAATAGA
CATGTATTTGCTTAAAACGTCTACCTATTCCATTTAATTTCCTGCTGATAAATGTATTTTATCTACAAGCAAGTAGAATATTTTGTTTTGGTTAAAGTCA
AGTTTTTATAAAAGGAGGGGAAGTATAAGAGAGAGTTTCCTAGAGATACAATATCATCTCTGGAGCAAAATGTTGAGGCCAAGTGTAAAAACAGACTATT
TCTCTTTACTTCCTGCAGAATTTCATTTCAAGGGACCACAGCACACCCTTGAAAATTACCATTTATTTAATGCCAGTTGAACCAATGGGTAGCAAAAGAG
GAGGGAGGGAACATGGTCATAGAGACAAAATCTAACTACTATACCAGGTCTTCCTTTGTAAGAAATATTAGCCCTGCCAATATAAAACGCAGATGGACAT
AGACAGAATAAGCATCGAGGACTTTTTCTTATTTACTTGAAATCTAGAAGCTCAGTCATCTCTGCTCATCCCTGGACCCACTGGAGAGTTTTACTCACTA
ACAGGTCCTTTCCTGGAAGAAATAACCTCATCTCCTGCCATATTAGTTTACAATAAAAATCATTCCAAAGTGAGCCATTTCACATTGCATTTTTGCCACA
TGCACATTTGCTATTGAAACCACAGATTCTCAGCATAAGTAAGACATAGGTGTTTCAGAAACTTCATAAATACACGATCTTTCAGGTGCTCCTCAATTTC
TTAATCAAGGTATATTGAACTCCAGTGATTAGGATAGAACCTGAAAACATCCTTTGTTCTATTGGATAGTACAACACAGCAAGAGCACACAGTTATTTGT
ATAATAAAACAACTTAATTAATGAGGAAGATGGGATGTTTGATTCCTGCTACCACCAGTTCACTTCACAAAGGCCTTCTTCTGGTATTACCAGGAAAACT
TTCCTGCATTTTCTAGGGAAAAAGAAAAGTCGTTTATTAGGAGCACAATGCAGATATGTATCTGTGTTTTCATAGCTTCAGCAAACTTCTTAGTAAAATT
CCCATTTCAACAAAAACCAAAATACTGATTGTTTGAATGTAGAAAGGTATAGAATAAAGACTACAAAGGGGAATTTTACCAGGGCTCCTTAGACCAGCTT
CCCCAGCATAATTTTTATATAACTCAAGTAAGCCTCTGCTTCCCCTCTCCTTTCCAGTATAATATAAGAAGGTCGGAACTGTCGCACAAAAGAACTTGAT
TTCAATATGAAAATATAATATGTAATTTTGGGGACTGCAGACTTTCTGCATCAAAGATCTGGACAGCCTTAACTTTTATAAAAATAATTTTTCAATGTTC
TCTTTTACTAACCAGGAAAACAAGATGTTTTCTGAAATTAATGACTTTTTCTATTTTGGGTCTGTTTTCTAAGTTTTTACAGGTTGAGGTATAAAGGGTC
GTCTTCTCCTCATATTGCCTCTTCATAATCACCTGGGGCTATTTTTTGCAAGTCACTGCATTTTTACAAAAAATAAAAATAAAAAGTACATCTCACAAAT
CATAAAATTCTCCCTAGACTTCAGACAGTCCTTCTGGAGTGAAAGAATAGAAATACAGAAAGAAAAGAATTACAGGGTGGCTTTCTTTTTATTTTCCTAT
GGTTAATGTACTGTATGGTATATATGTTTACAGAATGTATCTGCCTTGTGATGTTAACAAAATGAATGACAAAAAATAGTACTGATGTGCCATTTGACAG
TTTGCCTTAGCATCACTGTTTATGTTCTTCTTTTCTGTCCTTTTTGGTAAAAAAAAACGCAGGTTGTATTCCAAAGCTGTATTAACACAACATTCTCTTC
CCCACTCCTACCCAGCCTTCTTCAGAGCTGTGAATTTCATTACAGGAGCATTGAGGCAGAACCTTGCAGGTGTGGCCCAAAGGGGCTAAAGTGGGCATAG
GTTGGGATTTACTTCTGCCCGTCTACCAACCAAACACGTATCTGTGTTCTCATATAAGCCTGCAAAATTTTACACCCTGCCTTTCAGGGAGACAGGCCAC
ATGGAGCGCATGACCTCTTGTAGTCGTCTCCTCACAGTCCTTCCCACTGTGAGAGAAGGAAACTTGCAGACCCCCAACTGGATCTGGGAGCATATTTTTA
AGCACAGTTGGCATTGCTTGAAAAAGCAAGAGAGATGGACTCAAATTCTATGATTGAGCCATGACTGAGGAATGTGCCCATTCGTTATAGTCGAAGATGA
GTAGGATGATATGGGTGAGAATAGGAGTGGCTGTAGAAATGGAATATTTTACAGTTATGTATTTTTTTAAGGAATAGTATTTTTATAATGAAATCTATAT
ACATTATGGAGCTTGAGTTGGAAAACACCCTTGACTGAGCTATTTCTTCATTCCATTAAAGGTAACTTTCTGGGGAGTCCTATAGCACTAGGCCAAGCCT
TGGGGGCATGAACAAAGGGCCTGTCACTTGGCCTTGCACTGCCATTACATGAGATCCAGTGTTTCCAAATAGGCCTTGGTTGGAAGATTGAGCTTTCTAT
ACCTGCCATTAGGTAGATTAGATAGATGGCTTGATAGCTCTCTGGGCTATACTTTTAATAATATATAATAATCTTTGGGAAGGAGATAGCTATTTTAAAT
GCAAGCAAAGCCCAGAAACTATCAAAGTCCAAATCTTTCACATATTTAAGGAGTAATTGCCACATTTGAGGTTAAGGGACCACTTACTATGGTGCATTTG
AGAAATATATATGAAACGGTGAGTCAGAGCCCTCTGACCATCTTCAGTCTACACATAAGCAGATAAACCACCAATATAAATCTTATAGGGGCCAGACGAG
GTGGCTTATGCCTGTAATCCCAGCACTTTGGGGGGCCAAGGCAGGAGGATAGTGTGAGCCCAGAAGTTCAAGACCAGGCTAGGCAACATGTTGAGACCAT
GTTGTTTAGTCTCTACTAAAAAATATAAAAATTAGCCAGCATGGTGGCACACACCTGTAGTCCCAGCTACTTGGGAGACTGAGGCAGGAGGATCACTTGA
GCCCAGGAGGTGGAGGCTGCAGGGGGCTGAGATCTCACCACTCCATTCCAGCCTGGGCAACAGAGCAAGACTCTGTCTCAAAAAAAAAAACAAAAAAACA
ATTATCAGTTGGCCTTCTACATAACACAGGGCTACACTGTATTTTTAGAGTTAAGTAGATACAGGAAAAGATTGTCTTTATCCATAAAGGAGATTCTGAA
TTTTTAGAGTTCCTGAATATTTTCCCCCAAGTTTCTGTCAAATTCCTGAAGTCCCTTCCCTATCACACTCAGTTTCCTGAAGCTCTTCCCCTACACCTGC
TCCTCTGTCTGGCTAACAGAGTTGTCATGTCTCAGAAACTACTCACCACTCTTGTGAGACTCTCTTCCCAAGCATCATCCTTCCTCAGGATGAGGCCTTT
TTCTACTACCCAAGAGATCAAGACCCTTTTTCTAACAAGACAAGGTTATATCTACTCCATTTTCAAGAGAAATAACCCCTCTGGTTCCCATGCAAATCGC
TTAAATTCCTTCATCACCAGAATCTCTCCAACAGGCCCAACTCCAGCCCAGCTGTGAACACTGCTGTCATGGAGACAACTCCAAAATGAAAGAACTATGC
AATTGCCTGAAGGTGCTAATGGAGAGCCAGTTTACTCTAATCTCTTATTACTAAGGAACCTCTCGGTTTCGAGATTAAGTGGGCAGGGAGACATCCAGTC
ACTTAGTTTTGCAATGACAGGTCTTGATATACACAGAGGCCACCAGGCAATGCCTGATCCAAACTATTCTGTATGTAGCTCCAACTCCAATTCTGTGATA
TCCTATTCTGGCAGGTGGGAAGAGTTCTATTCTTTGCAGGGTTCTGGAACATTCTTTCCTGCTCTCAAGCTCCTGACTTAGGAGAGTCAAAATCATACAG
GGGTTCCAGAAAATGTTGTGTCTGATGCAGCTTCTCAGTGAATGTAGGTTGTTGGTGAAATTTTCAGCTTTAGCATCTCACTCGGGGTGAGTGATGTCTC
TGTAAATACTTTCATTTGTGGTTGGTTGGTGGGGGTGGGGGTGGGAGCCTGTCGTGCTTACTCTGAATTAGCTTACTGGGCTAGCTGCTGTACTTTGTAA
CCTGAAGTGTACTTTGACTGTTCTGTTTCCTTCAGATGAAAAACAAAATAAAAACCGACTTCAGAAAAGACACTACCAGCGACAGCTGATGCTGTACTTG
TAGCTTCTCTCTGTTCCTCTGTACAGTATTAATAGACAATAAACTGCCTTTTCACTGCATCTA
  • refseq_PALM2.F1 (forward primer)
  • refseq_PALM2.R1 (reverse primer)
  • Single exon skipping

Frame 0

TRLRERRAAPVSPAAAHPAAEPRDGDGRGGIAQ
GKAASHSRKKKEAD*NRRQATTA*RADTSAAAFQ
VQSASGEMAAAGHTRWNCRRGGSQEAAV*RG*V
QSQAT*R*HSEAGARNTNARK*RVPDICQRANH
PRETEGNRKILQGLSEGFLQYGWRCSKLHFLPAS
RPANPLFTNSRTITWAGRDQQSGC
CVRHGN*CG
ERQTNRRDQDSLYIYHWPRGGPSERSQSL**WY
QSSV*GA
LRRHRSRKWSAQIKHKGCRRAYSEGWT
IKLRRRARV*KDCDCRWEPQPSQGTHALQRS*V
RNGT*V*ERPFFREPRAAGPSPQRCRAGGKLGS
ARHHDFYGLPKYRG*RGDEKGARL**NHQG*IGP
H**R**EVIEGEDSDGRVHY*RERG*ACVREAG
LRHHRALIPRREGREPSYRASPRYPKEKALSML
CCHVTTSFFSFLLGSLYSPPLT*TSLYH*LQYCE
LEANTCLALQLNCFDLSHFFSFSSPERQRACVC
FILSKNLLFL*TFPCVFKSESLPSCSIGMDSSY
QPVIW*P*LT*LELNPLALGVSFCSVFL*RSHTL
PCLWFLTCLLCCGSLFLYLVWQNAVGSSRLLV*
PKVDLT*SVRSRVMLFAALHKLPDYSIVHSWLS
FC*N*NEVNVEEPRACHS*NVGTDSITCPSAVVS
LSMV*PMNPLYKKHHFKISKDMKQTLFEASVAI
DLQT*ANSQALFLFS*KNVNFYIVSFFWIFSGH
VNLFSMRRSS*EVSLQ*PYF*NSLSNLQWLP*CS
HFIMDGAVMH*LFISSPVDYKALHPYSFLSGPM
RKRMF*VTSTCRFICPSKKKTLKNF*KLRKTYL
LNVKHLIS*QILSGT*LSFLGHCFVFSFWRFQKS
KEYFLSRTQ*TVFEIPSQHSPKAKSHICSKTKG
KQFNKITIV***NKDIT*LLVLIRVILTLSYLP
IYSIVMNYS*NYVPQYIVLKKHMIYYIQSNFCGK
*IRKNKIVLREFYYRSCLI*PILLAQC*IYCFF
LISWLEIIFTSIGKVKTSVFTFQS*FSEIIAF*
*AQNGSFYFYYTHLVYTYT*TENVKEEKNKGAKF
CC*RLFHPRLGFE*LREISLNLKFIKAAAME*N
CYFIEKPGLDAYKFHYSQLHFPEYVVTEASFRH
YINWHADKPIYIEGENSFNVLDNLLF**FT*ERN
NLKAYHSLSFLLTWRFKLFNVSFKKLSTVSE*N
GRM*NL*ACWLINRINLPGQIIP*RDLSLHK*T
SYSYRK*SAHLTTTLHTRTKRLMIICILFTNYYY
GGIMISKLYEFEFSLYFY**SLSFNGLK*DVLP
LFELFVATLNEGVFEYGAYICICPIIFLS*WGI
QA*PVLLWDETYNPTYSSK*LPFMMIVYMEL*L*
TCCLSCCHWHSLCKFYYVWYHTLQKCRVFGYIT
KLIKESVMKLQNHDLF*AND*LGFPLK*YNQAE
CSGSHL*SRHFGSPRRVVHLRSGVQDQPDQHGET
PISTKKKIQN*PGVMAHACNPSYSGD*GRRIA*
TWEAGVAMSRDVHSSLGNKERNSISKKKKKKKK
SYNQFPFK*KEEEKKKEKGGYLICIQIDFQWHLI
KDSLMVKMIKINSTYLEKS**LLYS*LLKNIFF
LLVCNKTN*GEFFQLVSLLPILFSLHKQKNNNC
L*N*FDSVQ*HHLILVMGWKRR*GMPLWPNLKHS
FLEPSEQS*NYSEAFRKLKFY*FDLVPFQNVNR
HVFA*NVYLFHLISC**MYFIYKQVEYFVLVKV
KFL*KEGKYKREFPRDTISSLEQNVEAKCKNRLF
LFTSCRISFQGTTAHP*KLPFI*CQLNQWVAKE
EGGNMVIETKSNYYTRSSFVRNISPANIKRRWT
*TE*ASRTFSYLLEI*KLSHLCSSLDPLESFTH*
QVLSWKK*PHLLPY*FTIKIIPK*AISHCIFAT
CTFAIETTDSQHK*DIGVSETS*IHDLSGAPQF
LNQGILNSSD*DRT*KHPLFYWIVQHSKSTQLFV
**NNLINEEDGMFDSCYHQFTSQRPSSGITRKT
FLHFLGKKKSRLLGAQCRYVSVFS*LQQTS**N
SHFNKNQNTDCLNVERYRIKTTKGNFTRAP*TSF
PSIIFI*LK*ASASPLLSSII*EGRNCRTKELD
FNMKI*YVILGTADFLHQRSGQP*LL*K*FFNV
LFY*PGKQDVF*N**LFLFWVCFLSFYRLRYKGS
SSPHIASS*SPGAIFCKSLHFYKK*K*KVHLTN
HKILPRLQTVLLE*KNRNTERKELQGGFLFIFL
WLMYCMVYMFTECICLVMLTK*MTKNSTDVPFDS
LP*HHCLCSSFLSFLVKKNAGCIPKLY*HNILF
PTPTQPSSEL*ISLQEH*GRTLQVWPKGAKVGI
GWDLLLPVYQPNTYLCSHISLQNFTPCLSGRQAT
WSA*PLVVVSSQSFPL*EKETCRPPTGSGSIFL
STVGIA*KSKRDGLKFYD*AMTEECAHSL*SKM
SRMIWVRIGVAVEMEYFTVMYFFKE*YFYNEIYI
HYGA*VGKHP*LSYFFIPLKVTFWGVL*H*AKP
WGHEQRACHLALHCHYMRSSVSK*ALVGRLSFL
YLPLGRLDRWLDSSLGYTFNNI**SLGRR*LF*M
QAKPRNYQSPNLSHI*GVIATFEVKGPLTMVHL
RNIYETVSQSPLTIFSLHISR*TTNINLIGARR
GGLCL*SQHFGGPRQEDSVSPEVQDQARQHVETM
LFSLY*KI*KLASMVAHTCSPSYLGD*GRRIT*
AQEVEAAGG*DLTTPFQPGQQSKTLSQKKKQKN
NYQLAFYITQGYTVFLELSRYRKRLSLSIKEILN
F*SS*IFSPKFLSNS*SPFPITLSFLKLFPYTC
SSVWLTELSCLRNYSPLL*DSLPKHHPSSG*GL
FLLPKRSRPFF*QDKVISTPFSREITPLVPMQIA
*IPSSPESLQQAQLQPSCEHCCHGDNSKMKELC
NCLKVLMESQFTLISYY*GTSRFRD*VGRETSS
HLVLQ*QVLIYTEATRQCLIQTILYVAPTPIL*Y
PILAGGKSSILCRVLEHSFLLSSS*LRRVKIIQ
GFQKMLCLMQLLSECRLLVKFSALASHSG*VMS
L*ILSFVVGWWGWGWEPVVLTLN*LTGLAAVLCN
LKCTLTVLFPSDEKQNKNRLQKRHYQRQLMLYL
*LLSVPLYSINRQ*TAFSLHL

Frame 1

LGSGRGEQRR*APQQRTRPRSPAMEMAEAELHK
ERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHS
KSKVLREKWLLQGIPAGTAEEEEARRRQSEEDEF
RVKQLEDNIQRLEQEIQTLESEESQISAKEQII
LEKLKETEKSFKDFQKGFSSTDGDAVNYISSQL
PDLPILCSRTAEPSPGQDGTSRAA
AVYAMEINVE
KDKQTGETKILSTSTIGPEGVHQKGVKVYDDGT
KVVYEVR
SGGTVVENGVHKLSTKDVEELIQKAG
QSSLGGGHVSERTVIADGSLSHPKEHMLCKEAKL
EMVHKSRKDHSSGNPGQQAQAPSAAGPEANLDQ
PVTMIFMGYQNIEDEEETKKVLGYDETIKAELV
LIDEDDEKSLREKTVTDVSTIDGNAAELVSGRPV
SDTTEPSSPEGKEESLATEPAPGTQKKKRCQCC
VVM*PLLSSPFFWAACTLHHSRRPHCTTNCNTV
NWKQTPALPCS*IALISLIFFPFPHLRDNVHVCA
SFSPRTCFSSKPFLVSSRVNHFLPARLEWTLRI
SQ*YGSLNSLDWN*THWHWGFHFVVCSCNVVTH
CHVSGFSLASFAVDLCFYILCGKMLLALAGC*CS
QKWTLLSLSDLG*CFLLPYISFQITVLCIHGFL
SVKTEMKSM*KNPELVTAEM*GLIP*PAHQRLS
LFLWFNR*TLYIRSTILKFLRT*NKHCLKHQ*QL
ISKLRQIHKPCFYSLKKM*IFILFLFSGYFLVM
LIYFQ*GDHLEKYLCSDHISKTVCPTYNGCHDA
PTSSWMVL*CINCSSPPQLITKPCIHTLFFLAP*
ERECFR*LQLVGLSALQKKKL*KTFKN*ERPIF
SMLST*FHNKY*VAHS*AS*GIVLFLASGDSRR
AKNIFYLEHNEQFLKYLLSTPPKQKATYVVKPKG
NNLIK*Q*YSNEIKI*HDYWF**ELS*L*VICP
FIALL*IIHKIMSHSI*F*KNI*YTTSSLTSVE
SRSEKIR*S*ENFIIEAV*FDLFCLLSAKSIAFF
*SPGLKLYLLQ*ER*KHQFLLFKVNFLK*LHFN
EHKMGHFIFIILILFTPIHKQKTLKKRKIKELS
SAVEDYFIQGLVLNN*GKYL*ISSSSKQLQWNKI
AILSRNLVWMLINSTTLSFIFLSTWSLKHHLDI
T*TGMQINLFT*REKTVSMSWTICYFNDLLKKE
TI*KLTIAYLFYSLGDSSYSM*VLKS*AQLVSEM
VECRTFKLAG**TESIFQDR*FPEGTYPCISEL
VTHTENDLHILLQHYTQELKD**LSVFSSLITI
MGE**LANYMNSSSLYTFISKAYHLMD*SKMCYL
YSSYL*PH*MKVCLNMAHIFAYVPSFSCHNGEF
RLSQYFYGMRPIIPPIAASNYPS***CTWSCDY
EHAAFPAAIGILSVNFIMCGITLSKNAGYLVT*P
N*LKNQ**NCKTMIFFELMISWAFL*NNIIRPS
AAAHTCNLGTLEVRGGWFT*GREFKTSLTNMEK
PPSLLKKKYKISQA*WRMPVIPATRETEAGESLE
PGRQGLQ*AEMCTPAWATKSETPSQKKKKKKKN
HIISSLLNRKRRKKKRKRGGISFVYK*IFNGI*
*KIL*WLK**RLILHILKNLNDFCILDFLKIFSF
F*CAIRQTKGNFFSLYLFYPYYFPCISKKIIIA
SKTDLTVFSDII*YW*WGGREGRECPYGQT*NT
VSLSLLSNLRIIQKLSGNSNSINLIWFLSKMLID
MYLLKTSTYSI*FPADKCILSTSK*NILFWLKS
SFYKRRGSIRESFLEIQYHLWSKMLRPSVKTDY
FSLLPAEFHFKGPQHTLENYHLFNAS*TNG*QKR
REGTWS*RQNLTTIPGLPL*EILALPI*NADGH
RQNKHRGLFLIYLKSRSSVISAHPWTHWRVLLT
NRSFPGRNNLISCHISLQ*KSFQSEPFHIAFLPH
AHLLLKPQILSISKT*VFQKLHKYTIFQVLLNF
LIKVY*TPVIRIEPENILCSIG*YNTARAHSYL
YNKTT*LMRKMGCLIPATTSSLHKGLLLVLPGKL
SCIF*GKRKVVY*EHNADMYLCFHSFSKLLSKI
PISTKTKILIV*M*KGIE*RLQRGILPGLLRPA
SPA*FLYNSSKPLLPLSFPV*YKKVGTVAQKNLI
SI*KYNM*FWGLQTFCIKDLDSLNFYKNNFSMF
SFTNQENKMFSEINDFFYFGSVF*VFTG*GIKG
RLLLILPLHNHLGLFFASHCIFTKNKNKKYISQI
IKFSLDFRQSFWSERIEIQKEKNYRVAFFLFSY
G*CTVWYICLQNVSAL*C*QNE*QKIVLMCHLT
VCLSITVYVLLFCPFW*KKTQVVFQSCINTTFSS
PLLPSLLQSCEFHYRSIEAEPCRCGPKGLKWA*
VGIYFCPSTNQTRICVLI*ACKILHPAFQGDRP
HGAHDLL*SSPHSPSHCERRKLADPQLDLGAYF*
AQLALLEKAREMDSNSMIEP*LRNVPIRYSRR*
VG*YG*E*EWL*KWNILQLCIFLRNSIFIMKSI
YIMELELENTLD*AISSFH*R*LSGESYSTRPSL
GGMNKGPVTWPCTAIT*DPVFPNRPWLED*AFY
TCH*VD*IDGLIALWAILLIIYNNLWEGDSYFK
CKQSPETIKVQIFHIFKE*LPHLRLRDHLLWCI*
EIYMKR*VRAL*PSSVYT*ADKPPI*IL*GPDE
VAYACNPSTLGGQGRRIV*AQKFKTRLGNMLRP
CCLVSTKKYKN*PAWWHTPVVPATWETEAGGSLE
PRRWRLQGAEISPLHSSLGNRARLCLKKKNKKT
IISWPST*HRATLYF*S*VDTGKDCLYP*RRF*
IFRVPEYFPPSFCQIPEVPSLSHSVS*SSSPTPA
PLSG*QSCHVSETTHHSCETLFPSIILPQDEAF
FYYPRDQDPFSNKTRLYLLHFQEK*PLWFPCKS
LKFLHHQNLSNRPNSSPAVNTAVMETTPK*KNYA
IA*RC*WRASLL*SLITKEPLGFEIKWAGRHPV
T*FCNDRS*YTQRPPGNA*SKLFCM*LQLQFCD
ILFWQVGRVLFFAGFWNILSCSQAPDLGESKSYR
GSRKCCV*CSFSVNVGCW*NFQL*HLTRGE*CL
CKYFHLWLVGGGGGGSLSCLL*ISLLG*LLYFV
T*SVL*LFCFLQMKNKIKTDFRKDTTSDS*CCTC
SFSLFLCTVLIDNKLPFHCI

Frame 2

SAPGEASSAGEPRSSAPGRGAPRWRWQRRNCTR
KGCKP*QKKERGRLK*KASDNSLTSRYFCCSIP
SPKCFGRNGCCRAYPLELPKRRKPGGGSLKRMS
SESSNLKITFRGWSKKYKR*KVKSPRYLPKSKSS
*RN*RKQKNPSRTFRRVSPVRMEMQ*ITFPPSF
PTCQSSVHEQQNHHLGRTGPAERL
LCTPWKLMW
RKTNKQERPRFSLHLPLAQRGSIRKESKSMMMVP
K*CMRC
AQEAP**KMECTN*AQRM*KSLFRRLD
NQA*EEGTCLKGL*LQMGASAIPRNTCSAKKLS
*KWYISLGKTILPGTQGSRPKPPALQGRRQTWIS
PSP*FLWATKISRMKRRRKRC*AMMKPSRLNWS
SLMKMMRSH*GRRQ*RTCPLLTGTRLSLCPGGR
SQTPQSPHPQKGRKRA*LQSQPQVPKRKSAVNAV
LSCDHFFLLLSSGQPVLSTTHVDLTVPLTAIL*
TGSKHLPCLAVELL*SLSFFFLFLT*ETTCMCV
LHSLQELAFPLNLSLCLQE*ITSFLLDWNGLFVS
ASDMVALTHLTGIEPIGTGGFIL*CVPVT*SHT
AMSLVSHLPPLLWIFVFISCVAKCCWL*PVASV
AKSGPYLVCPI*GDAFCCLT*ASRLQYCAFMAFF
LLKLK*SQCRRTQSLSQLKCRD*FHNLPISGCL
SFYGLTDEPFI*EAPF*NF*GHETNIV*SISSN
*SPNLGKFTSLVSILLKKCKFLYCFFFLDIFWSC
*SIFNEEIILRSIFAVTIFLKQSVQPTMVAMML
PLHHGWCCNALTVHLLPS*LQSLASILFSFWPH
EKENVLGNFNL*VYLPFKKKNFKKLLKIKKDLSS
QC*ALNFITNIKWHIAELLRALFCF*LLEIPEE
QRIFFI*NTMNSF*NTFSALPQSKKPHM**NQR
ETI**NNNSIVMK*RYNMITGFNKSYLNFKLFAH
L*HCYELFIKLCPTVYSFEKTYDILHPV*LLWK
VDQKK*DSLERILL*KLSNLTYFACSVLNLLLF
FNLLA*NYIYFNRKGKNISFYFSKLIF*NNCILM
STKWVILFLLYSSCLHLYINRKR*RREK*RS*V
LLLKIISSKAWF*ITEGNISKSQVHQSSCNGIK
LLFYRETWFGCL*IPLLSASFS*VRGH*SII*TL
HKLACR*TYLHRGRKQFQCLGQSVILMIYLRKK
QSESLP*LIFSTHLEIQAIQCEF*KVKHS**VK
W*NVEPLSLLVDKQNQSSRTDNSLKGPILA*VN*
LLIQKMICTSYYNTTHKN*KINDYLYSLH*LLL
WGNND*QII*IRVLSILLLVKLII*WTEVRCVT
FIRAICSHTK*RCV*IWRIYLHMSHHFLVIMGNS
GLASTSMG*DL*SHL*QQVTTLHDDSVHGAVIM
NMLPFLLPLAFSL*ILLCVVSHSPKMQGIWLHN
QTN*RISNEIAKP*SFLS**LVGLSFKII*SGRV
QRLTPVISALWKSAAGGSPEVGSSRPA*PTWRN
PHLY*KKNTKLARRDGACL*SQLLGRLRQENRL
NLGGRGCNEPRCALQPGQQRAKLHLKKKKKKKKI
I*SVPF*IERGGKKKGKGGVSHLYTNRFSMAFN
KRFFNG*NDKD*FYIS*KILMTSVFLTS*KYFL
SFSVQ*DKLRGIFSACISFTHIIFLA*AKK**LP
LKLI*QCSVTSFNIGDGVEEKVGNALMAKPKTQ
FP*AF*AILELFRSFQETQILLI*FGSFPKC**
TCICLKRLPIPFNFLLINVFYLQASRIFCFG*SQ
VFIKGGEV*ERVS*RYNIISGAKC*GQV*KQTI
SLYFLQNFISRDHSTPLKITIYLMPVEPMGSKR
GGREHGHRDKI*LLYQVFLCKKY*PCQYKTQMDI
DRISIEDFFLFT*NLEAQSSLLIPGPTGEFYSL
TGPFLEEITSSPAILVYNKNHSKVSHFTLHFCH
MHICY*NHRFSA*VRHRCFRNFINTRSFRCSSIS
*SRYIELQ*LG*NLKTSFVLLDSTTQQEHTVIC
IIKQLN**GRWDV*FLLPPVHFTKAFFWYYQEN
FPAFSREKEKSFIRSTMQICICVFIASANFLVKF
PFQQKPKY*LFECRKV*NKDYKGEFYQGSLDQL
PQHNFYITQVSLCFPSPFQYNIRRSELSHKRT*
FQYENIICNFGDCRLSASKIWTALTFIKIIFQCS
LLLTRKTRCFLKLMTFSILGLFSKFLQVEV*RV
VFSSYCLFIITWGYFLQVTAFLQKIKIKSTSHK
S*NSP*TSDSPSGVKE*KYRKKRITGWLSFYFPM
VNVLYGIYVYRMYLPCDVNKMNDKK*Y*CAI*Q
FALASLFMFFFSVLFGKKKRRLYSKAVLTQHSL
PHSYPAFFRAVNFITGALRQNLAGVAQRG*SGHR
LGFTSARLPTKHVSVFSYKPAKFYTLPFRETGH
MERMTSCSRLLTVLPTVREGNLQTPNWIWEHIF
KHSWHCLKKQERWTQIL*LSHD*GMCPFVIVEDE
*DDMGENRSGCRNGIFYSYVFF*GIVFL**NLY
TLWSLSWKTPLTELFLHSIKGNFLGSPIALGQA
LGA*TKGLSLGLALPLHEIQCFQIGLGWKIELSI
PAIR*IR*MA**LSGLYF**YIIIFGKEIAILN
ASKAQKLSKSKSFTYLRSNCHI*G*GTTYYGAF
EKYI*NGESEPSDHLQSTHKQINHQYKSYRGQTR
WLMPVIPALWGAKAGG*CEPRSSRPG*ATC*DH
VV*SLLKNIKISQHGGTHL*SQLLGRLRQEDHL
SPGGGGCRGLRSHHSIPAWATEQDSVSKKKTKKQ
LSVGLLHNTGLHCIFRVK*IQEKIVFIHKGDSE
FLEFLNIFPQVSVKFLKSLPYHTQFPEALPLHL
LLCLANRVVMSQKLLTTLVRLSSQASSFLRMRPF
STTQEIKTLFLTRQGYIYSIFKRNNPSGSHANR
LNSFITRISPTGPTPAQL*TLLSWRQLQNERTM
QLPEGANGEPVYSNLLLLRNLSVSRLSGQGDIQS
LSFAMTGLDIHRGHQAMPDPNYSVCSSNSNSVI
SYSGRWEEFYSLQGSGTFFPALKLLT*ESQNHT
GVPENVVSDAASQ*M*VVGEIFSFSISLGVSDVS
VNTFICGWLVGVGVGACRAYSELAYWASCCTL*
PEVYFDCSVSFR*KTK*KPTSEKTLPATADAVL
VASLCSSVQY**TINCLFTAS

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