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Sequences

Sequence NM_000293

GGCCAAGGCGGCGACCGGAGCGCGATGGCGGGGGCGGCGGGACTCACGGCAGAAGTGAGCTGGAAGGTCTTGGAGCGAAGAGCTCGGACCAAGCGCTCAG GCTCAGTTTATGAACCTCTTAAAAGCATTAATCTTCCAAGACCTGATAATGAAACTCTCTGGGATAAGTTGGACCATTATTACAGAATTGTCAAGTCAAC ATTGCTGCTGTATCAAAGTCCAACTACCGGTCTCTTTCCCACTAAAACATGCGGTGGTGACCAGAAGGCCAAGATCCAGGACAGCCTATACTGCGCTGCT GGGGCCTGGGCTTTGGCTCTTGCATACAGGCGAATTGATGATGACAAGGGAAGGACCCATGAGCTGGAGCACTCAGCTATAAAATGCATGAGAGGAATTC TCTACTGCTATATGCGTCAGGCCGATAAGGTCCAGCAGTTTAAGCAGGATCCACGCCCAACAACATGTCTTCACTCTGTTTTCAATGTGCATACAGGAGA TGAGTTGCTTTCCTATGAGGAATATGGTCATCTTCAGATAAATGCAGTGTCACTTTATCTCCTTTACCTTGTGGAAATGATTTCCTCAGGACTCCAGATT ATCTACAACACTGATGAGGTCTCTTTTATTCAAAACCTTGTATTTTGTGTGGAAAGAGTTTACCGTGTGCCTGACTTTGGTGTCTGGGAAAGAGGAAGCA AATATAATAATGGCAGCACAGAGCTACATTCGAGCTCGGTTGGTTTAGCAAAAGCAGCTCTAGAAGCAATTAATGGATTCAACCTTTTTGGCAACCAGGG CTGTTCGTGGTCAGTTATATTTGTGGATCTCGATGCTCACAATCGCAACAGGCAAACTTTGTGCTCGCTGTTACCCAGAGAATCAAGATCACATAATACA GATGCTGCCCTGCTCCCCTGCATCAGTTATCCTGCATTTGCCCTGGATGATGAAGTTCTTTTTAGCCAGACACTTGATAAAGTGGTTAGAAAATTAAAAG GAAAATATGGATTTAAACGTTTCTTGAGAGATGGGTATAGAACATCATTGGAAGATCCCAACAGATGCTACTACAAGCCAGCTGAAATTAAGCTATTTGA TGGCATTGAATGTGAATTTCCCATATTTTTCCTTTATATGATGATTGATGGAGTTTTTAGAGGCAATCCTAAGCAAGTACAGGAATATCAGGATCTTTTG ACTCCAGTACTTCATCATACCACAGAAGGATATCCTGTTGTACCAAAGTACTATTATGTGCCAGCTGACTTTGTAGAATATGAAAAAAATAACCCTGGTA GTCAAAAACGATTTCCTAGCAACTGTGGCCGTGATGGAAAACTGTTTCTTTGGGGACAAGCACTTTATATCATCGCAAAACTCCTGGCTGATGAACTTAT TAGTCCTAAAGACATTGATCCTGTCCAGCGCTATGTCCCACTAAAGGATCAACGTAACGTGAGCATGAGGTTTTCCAATCAGGGCCCACTGGAAAATGAC TTGGTAGTTCATGTGGCACTTATAGCAGAAAGCCAAAGACTTCAAGTTTTTCTGAACACATATGGTATTCAAACTCAAACTCCTCAACAAGTAGAACCCA TTCAGATATGGCCTCAGCAGGAGCTTGTGAAAGCTTATTTGCAGCTGGGTATCAATGAAAAGTTAGGACTCTCTGGAAGGCCAGACAGGCCCATTGGCTG CCTCGGGACATCAAAGATTTATCGCATTCTAGGAAAGACTGTGGTTTGTTACCCGATTATTTTCGACCTAAGTGATTTCTACATGTCTCAGGATGTTTTC CTGCTGATAGATGACATAAAGAATGCGCTGCAGTTCATTAAACAATATTGGAAAATGCATGGACGTCCACTTTTCCTTGTTCTCATCCGGGAAGACAATA TAAGAGGTAGCCGGTTCAACCCCATATTAGATATGCTGGCAGCCCTTAAAAAAGGAATAATTGGAGGAGTCAAAGTTCATGTGGATCGTCTACAGACACT AATATCTGGAGCTGTGGTAGAACAACTTGATTTCCTACGAATCAGTGACACAGAAGAGCTTCCAGAATTTAAGAGTTTTGAGGAACTAGAACCTCCCAAA CATTCAAAAGTCAAACGGCAAAGCAGCACCCCTAGTGCTCCTGAACTGGGACAGCAGCCGGATGTCAACATTAGTGAATGGAAGGACAAACCCACCCACG AAATTCTTCAAAAACTGAATGATTGCAGTTGTCTGGCTAGCCAAGCCATCCTGCTGGGTATACTGCTCAAAAGAGAAGGCCCCAACTTCATCACAAAGGA AGGTACCGTTTCTGATCACATTGAGAGAGTCTATAGAAGAGCTGGCAGCCAAAAACTTTGGTTGGCGGTGCGCTACGGGGCTGCATTTACCCAGAAATTT TCTTCCTCTATAGCCCCACACATTACTACTTTTCTGGTACATGGGAAACAGGTAACTCTGGGTGCCTTTGGGCATGAAGAAGAAGTTATCTCTAATCCTT TGTCTCCAAGAGTGATTCAAAACATCATCTATTATAAGTGTAACACCCATGATGAGAGGGAAGCGGTCATTCAGCAAGAACTGGTCATCCATATTGGCTG GATCATCTCCAATAACCCTGAGTTATTCAGTGGCATGCTGAAAATACGAATCGGGTGGATCATCCATGCCATGGAGTATGAACTTCAGATCCGTGGCGGA GACAAGCCAGCCTTGGACTTGTATCAGCTGTCACCTAGTGAAGTTAAACAGCTTCTGCTGGATATTCTGCAGCCTCAACAGAATGGAAGATGTTGGCTGA ACAGGCGTCAGATCGATGGGTCTTTGAATAGAACTCCCACCGGGTTCTATGACCGAGTGTGGCAGATTCTGGAGCGCACGCCCAATGGGATCATTGTTGC TGGGAAGCATTTGCCTCAGCAACCAACCCTGTCAGATATGACCATGTATGAGATGAATTTCTCTCTCCTTGTTGAAGACACGTTGGGAAATATTGACCAG CCACAGTACAGACAGATCGTTGTAGAGTTACTTATGGTTGTATCCATTGTACTGGAAAGAAACCCCGAGCTAGAATTTCAAGACAAAGTAGATCTAGACA GACTGGTCAAAGAAGCATTTAATGAATTTCAAAAAGATCAGAGTCGGCTAAAGGAAATTGAAAAACAAGATGACATGACTTCCTTTTACAACACTCCTCC CCTGGGAAAAAGAGGAACATGCAGCTATTTGACAAAGGCGGTGATGAATCTGCTGCTGGAAGGAGAAGTCAAGCCAAACAATGATGACCCGTGTCTGATT AGCTAGTGGGGAAGGTGTAGGAAGCTCTGTTGAGACACATGTTCTGAAGTGTGTTGTGTTTCATGTTCAAGCTTAATCAAGGCAGCCATTAATATACGAA CTGAGCATGCTGGGGAGGTGAATGCCACATCCTTGGCGGGGTTATGGACCTCTTGCATGTCATAGCCAATCTAACGGTAATGGTAAATGCTTTTAATCAA GCAGGAAAAAGTTCTCATGATTATGCCAACTATAATAGTAATCCTCACTGAGTGATAAAAATAGTTTATGAATTGAAAATTTGCCGCTGCATGTTGTATG ATCAAATAGTTCATCAAAATGAATCTTTGCTCTTTGGACTGAATTCTTACCATACTGCCATTAAAATAAATTTGCCAACTAGTAATGCATACTGGAAATC AAAAGATACTGAAAGAATGGTGAACTTCTCTTAGTGGTATTGTCATGCTAAAAGATGTTAATATACATCATAAAAGCAAAGTCAGCCAGCTGATATTTTG GTTCTCAAAAACTGCATTATTAATAATATTTTAGTATACAGAGCTATTCTACAGTTTTTACATTGTAAACATGACTGTGGTTTTGTATTTGCTAAATATA GGGGTTGGACTAAAATATAATAAATCTGTACCTTATCAAACATTTTCTTTGAGCTCCTGCTAAAAATAGGACATGTCTATGATTGTTCAAAAATATGTTA AATTTAGGCTCAGCACAGTAGCTCACACCTGAAATCTTAGCACTTCGGGAGGCTGAGGCAGGTGGATCACTTGAGGTTAGGAGTTCAAGACCAGCCCAGC CAACATGGTGAAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCAGGCATGATGGTGCATGCCTTTAAACCCAGCTACTGAGGAGGCTGAGGCATGAG AATTGCTTGAACCAGGAGACGGAGGTTGCAGTGAGCTGAAATCCTGCCACTGCACACCAGCCTGGGTGACAGAGCGAGACTCC

refseq_PHKB.F1 (forward primer)
refseq_PHKB.R1 (reverse primer)
Single exon skipping

Frame 0

GQGGDRSAMAGAAGLTAEVSWKVLERRARTKRS GSVYEPLKSINLPRPDNETLWDKLDHYYRIVKST LLLYQSPTTGLFPTKTCGGDQKAKIQDSLYCAA GAWALALAYRRIDDDKGRTHELEHSAIKCMRGI LYCYMRQADKVQQFKQDPRPTTCLHSVFNVHTGD ELLSYEEYGHLQINAVSLYLLYLVEMISSGLQI IYNTDEVSFIQNLVFCVERVYRVPDFGVWERGS KYNNGSTELHSSSVGLAKAALEAINGFNLFGNQG CSWSVIFVDLDAHNRNRQTLCSLLPRESRSHNT DAALLPCISYPAFALDDEVLFSQTLDKVVRKLK GKYGFKRFLRDGYRTSLEDPNRCYYKPAEIKLFD GIECEFPIFFLYMMIDGVFRGNPKQVQEYQDLL TPVLHHTTEGYPVVPKYYYVPADFVEYEKNNPG SQKRFPSNCGRDGKLFLWGQALYIIAKLLADELI SPKDIDPVQRYVPLKDQRNVSMRFSNQGPLEND LVVHVALIAESQRLQVFLNTYGIQTQTPQQVEP IQIWPQQELVKAYLQLGINEKLGLSGRPDRPIGC LGTSKIYRILGKTVVCYPIIFDLSDFYMSQDVF LLIDDIKNALQFIKQYWKMHGRPLFLVLIREDN IRGSRFNPILDMLAALKKGIIGGVKVHVDRLQTL ISGAVVEQLDFLRISDTEELPEFKSFEELEPPK HSKVKRQSSTPSAPELGQQPDVNISEWKDKPTH EILQKLNDCSCLASQAILLGILLKREGPNFITKE GTVSDHIERVYRRAGSQKLWLAVRYGAAFTQKF SSSIAPHITTFLVHGKQVTLGAFGHEEEVISNP LSPRVIQNIIYYKCNTHDEREAVIQQELVIHIGW IISNNPELFSGMLKIRIGWIIHAMEYELQIRGG DKPALDLYQLSPSEVKQLLLDILQPQQNGRCWL NRRQIDGSLNRTPTGFYDRVWQILERTPNGIIVA GKHLPQQPTLSDMTMYEMNFSLLVEDTLGNIDQ PQYRQIVVELLMVVSIVLERNPELEFQDKVDLD RLVKEAFNEFQKDQSRLKEIEKQDDMTSFYNTPP LGKRGTCSYLTKAVMNLLLEGEVKPNNDDPCLI S*WGRCRKLC*DTCSEVCCVSCSSLIKAAINIR TEHAGEVNATSLAGLWTSCMS*PI*R*W*MLLIK QEKVLMIMPTIIVILTE**K*FMN*KFAAACCM IK*FIKMNLCSLD*ILTILPLK*ICQLVMHTGN QKILKEW*TSLSGIVMLKDVNIHHKSKVSQLIFW FSKTALLIIF*YTELFYSFYIVNMTVVLYLLNI GVGLKYNKSVPYQTFSLSSC*K*DMSMIVQKYV KFRLSTVAHT*NLSTSGG*GRWIT*G*EFKTSPA NMVKTLSLLKIQKLARHDGACL*TQLLRRLRHE NCLNQETEVAVS*NPATAHQPG*QSET

Frame 1

AKAATGARWRGRRDSRQK*AGRSWSEELGPSAQ AQFMNLLKALIFQDLIMKLSGISWTIITELSSQ HCCCIKVQLPVSFPLKHAVVTRRPRSRTAYTALL GPGLWLLHTGELMMTREGPMSWSTQL*NA*EEF STAICVRPIRSSSLSRIHAQQHVFTLFSMCIQE MSCFPMRNMVIFR*MQCHFISFTLWK*FPQDSRL STTLMRSLLFKTLYFVWKEFTVCLTLVSGKEEA NIIMAAQSYIRARLV*QKQL*KQLMDSTFLATR AVRGQLYLWISMLTIATGKLCARCYPENQDHIIQ MLPCSPASVILHLPWMMKFFLARHLIKWLEN*K ENMDLNVS*EMGIEHHWKIPTDATTSQLKLSYL MALNVNFPYFSFI**LMEFLEAILSKYRNIRIF* LQYFIIPQKDILLYQSTIMCQLTL*NMKKITLV VKNDFLATVAVMENCFFGDKHFISSQNSWLMNL LVLKTLILSSAMSH*RINVT*A*GFPIRAHWKMT W*FMWHL*QKAKDFKFF*THMVFKLKLLNK*NP FRYGLSRSL*KLICSWVSMKS*DSLEGQTGPLA ASGHQRFIAF*ERLWFVTRLFST*VISTCLRMFS C**MT*RMRCSSLNNIGKCMDVHFSLFSSGKTI *EVAGSTPY*ICWQPLKKE*LEESKFMWIVYRH *YLELW*NNLISYESVTQKSFQNLRVLRN*NLPN IQKSNGKAAPLVLLNWDSSRMSTLVNGRTNPPT KFFKN*MIAVVWLAKPSCWVYCSKEKAPTSSQR KVPFLITLRESIEELAAKNFGWRCATGLHLPRNF LPL*PHTLLLFWYMGNR*LWVPLGMKKKLSLIL CLQE*FKTSSIISVTPMMRGKRSFSKNWSSILA GSSPITLSYSVAC*KYESGGSSMPWSMNFRSVAE TSQPWTCISCHLVKLNSFCWIFCSLNRMEDVG* TGVRSMGL*IELPPGSMTECGRFWSARPMGSLL LGSICLSNQPCQI*PCMR*ISLSLLKTRWEILTS HSTDRSL*SYLWLYPLYWKETPS*NFKTK*I*T DWSKKHLMNFKKIRVG*RKLKNKMT*LPFTTLL PWEKEEHAAI*QRR**ICCWKEKSSQTMMTRV*L ASGEGVGSSVETHVLKCVVFHVQA*SRQPLIYE LSMLGR*MPHPWRGYGPLACHSQSNGNGKCF*S SRKKFS*LCQL***SSLSDKNSL*IENLPLHVV* SNSSSK*IFALWTEFLPYCH*NKFAN**CILEI KRY*KNGELLLVVLSC*KMLIYIIKAKSAS*YF GSQKLHY**YFSIQSYSTVFTL*T*LWFCIC*I* GLD*NIINLYLIKHFL*APAKNRTCL*LFKNML NLGSAQ*LTPEILALREAEAGGSLEVRSSRPAQ PTW*KPCLY*KYKN*PGMMVHAFKPSY*GG*GMR IA*TRRRRLQ*AEILPLHTSLGDRARL

Frame 2

PRRRPERDGGGGGTHGRSELEGLGAKSSDQALR LSL*TS*KH*SSKT***NSLG*VGPLLQNCQVN IAAVSKSNYRSLSH*NMRW*PEGQDPGQPILRC WGLGFGSCIQAN***QGKDP*AGALSYKMHERNS LLLYASGR*GPAV*AGSTPNNMSSLCFQCAYRR *VAFL*GIWSSSDKCSVTLSPLPCGNDFLRTPD YLQH**GLFYSKPCILCGKSLPCA*LWCLGKRKQ I**WQHRATFELGWFSKSSSRSN*WIQPFWQPG LFVVSYICGSRCSQSQQANFVLAVTQRIKIT*Y RCCPAPLHQLSCICPG**SSF*PDT**SG*KIKR KIWI*TFLERWV*NIIGRSQQMLLQAS*N*AI* WH*M*ISHIFPLYDD*WSF*RQS*ASTGISGSF DSSTSSYHRRISCCTKVLLCAS*LCRI*KK*PW* SKTIS*QLWP*WKTVSLGTSTLYHRKTPG**TY *S*RH*SCPALCPTKGST*REHEVFQSGPTGK* LGSSCGTYSRKPKTSSFSEHIWYSNSNSSTSRTH SDMASAGACESLFAAGYQ*KVRTLWKARQAHWL PRDIKDLSHSRKDCGLLPDYFRPK*FLHVSGCF PADR*HKECAAVH*TILENAWTSTFPCSHPGRQY KR*PVQPHIRYAGSP*KRNNWRSQSSCGSSTDT NIWSCGRTT*FPTNQ*HRRASRI*EF*GTRTSQ TFKSQTAKQHP*CS*TGTAAGCQH**MEGQTHPR NSSKTE*LQLSG*PSHPAGYTAQKRRPQLHHKG RYRF*SH*ESL*KSWQPKTLVGGALRGCIYPEI FFLYSPTHYYFSGTWETGNSGCLWA*RRSYL*SF VSKSDSKHHLL*V*HP**EGSGHSARTGHPYWL DHLQ*P*VIQWHAENTNRVDHPCHGV*TSDPWR RQASLGLVSAVT**S*TASAGYSAASTEWKMLAE QASDRWVFE*NSHRVL*PSVADSGAHAQWDHCC WEAFASATNPVRYDHV*DEFLSPC*RHVGKY*P ATVQTDRCRVTYGCIHCTGKKPRARISRQSRSRQ TGQRSI**ISKRSESAKGN*KTR*HDFLLQHSS PGKKRNMQLFDKGGDESAAGRRSQAKQ**PVSD *LVGKV*EALLRHMF*SVLCFMFKLNQGSH*YTN *ACWGGECHILGGVMDLLHVIANLTVMVNAFNQ AGKSSHDYANYNSNPH*VIKIVYELKICRCMLY DQIVHQNESLLFGLNSYHTAIKINLPTSNAYWKS KDTERMVNFS*WYCHAKRC*YTS*KQSQPADIL VLKNCIINNILVYRAILQFLHCKHDCGFVFAKY RGWTKI**ICTLSNIFFELLLKIGHVYDCSKIC* I*AQHSSSHLKS*HFGRLRQVDHLRLGVQDQPS QHGENPVSTKNTKISQA*WCMPLNPATEEAEA* ELLEPGDGGCSELKSCHCTPAWVTERDS

Sequence NM_001031835

GGCCAAGGCGGCGACCGGAGCGCGATGGCGGGGGCGGCGGGACTCACGGCAGAAGTGAGCTGGAAGGTCTTGGAGCGAAGAGCTCGGACCAAGCGCTCAG TTTTAAAATTGCTATAGCTTAGCCTGCGACGCTTATGATTAGAGCCAACAATTTGAAATGGCCTGCTCACCTGATGCAGTCGTCTCTCCGTCTTCCGCTT TCTTAAGGTCTGGCTCAGTTTATGAACCTCTTAAAAGCATTAATCTTCCAAGACCTGATAATGAAACTCTCTGGGATAAGTTGGACCATTATTACAGAAT TGTCAAGTCAACATTGCTGCTGTATCAAAGTCCAACTACCGGTCTCTTTCCCACTAAAACATGCGGTGGTGACCAGAAGGCCAAGATCCAGGACAGCCTA TACTGCGCTGCTGGGGCCTGGGCTTTGGCTCTTGCATACAGGCGAATTGATGATGACAAGGGAAGGACCCATGAGCTGGAGCACTCAGCTATAAAATGCA TGAGAGGAATTCTCTACTGCTATATGCGTCAGGCCGATAAGGTCCAGCAGTTTAAGCAGGATCCACGCCCAACAACATGTCTTCACTCTGTTTTCAATGT GCATACAGGAGATGAGTTGCTTTCCTATGAGGAATATGGTCATCTTCAGATAAATGCAGTGTCACTTTATCTCCTTTACCTTGTGGAAATGATTTCCTCA GGACTCCAGATTATCTACAACACTGATGAGGTCTCTTTTATTCAAAACCTTGTATTTTGTGTGGAAAGAGTTTACCGTGTGCCTGACTTTGGTGTCTGGG AAAGAGGAAGCAAATATAATAATGGCAGCACAGAGCTACATTCGAGCTCGGTTGGTTTAGCAAAAGCAGCTCTAGAAGCAATTAATGGATTCAACCTTTT TGGCAACCAGGGCTGTTCGTGGTCAGTTATATTTGTGGATCTCGATGCTCACAATCGCAACAGGCAAACTTTGTGCTCGCTGTTACCCAGAGAATCAAGA TCACATAATACAGATGCTGCCCTGCTCCCCTGCATCAGTTATCCTGCATTTGCCCTGGATGATGAAGTTCTTTTTAGCCAGACACTTGATAAAGTGGTTA GAAAATTAAAAGGAAAATATGGATTTAAACGTTTCTTGAGAGATGGGTATAGAACATCATTGGAAGATCCCAACAGATGCTACTACAAGCCAGCTGAAAT TAAGCTATTTGATGGCATTGAATGTGAATTTCCCATATTTTTCCTTTATATGATGATTGATGGAGTTTTTAGAGGCAATCCTAAGCAAGTACAGGAATAT CAGGATCTTTTGACTCCAGTACTTCATCATACCACAGAAGGATATCCTGTTGTACCAAAGTACTATTATGTGCCAGCTGACTTTGTAGAATATGAAAAAA ATAACCCTGGTAGTCAAAAACGATTTCCTAGCAACTGTGGCCGTGATGGAAAACTGTTTCTTTGGGGACAAGCACTTTATATCATCGCAAAACTCCTGGC TGATGAACTTATTAGTCCTAAAGACATTGATCCTGTCCAGCGCTATGTCCCACTAAAGGATCAACGTAACGTGAGCATGAGGTTTTCCAATCAGGGCCCA CTGGAAAATGACTTGGTAGTTCATGTGGCACTTATAGCAGAAAGCCAAAGACTTCAAGTTTTTCTGAACACATATGGTATTCAAACTCAAACTCCTCAAC AAGTAGAACCCATTCAGATATGGCCTCAGCAGGAGCTTGTGAAAGCTTATTTGCAGCTGGGTATCAATGAAAAGTTAGGACTCTCTGGAAGGCCAGACAG GCCCATTGGCTGCCTCGGGACATCAAAGATTTATCGCATTCTAGGAAAGACTGTGGTTTGTTACCCGATTATTTTCGACCTAAGTGATTTCTACATGTCT CAGGATGTTTTCCTGCTGATAGATGACATAAAGAATGCGCTGCAGTTCATTAAACAATATTGGAAAATGCATGGACGTCCACTTTTCCTTGTTCTCATCC GGGAAGACAATATAAGAGGTAGCCGGTTCAACCCCATATTAGATATGCTGGCAGCCCTTAAAAAAGGAATAATTGGAGGAGTCAAAGTTCATGTGGATCG TCTACAGACACTAATATCTGGAGCTGTGGTAGAACAACTTGATTTCCTACGAATCAGTGACACAGAAGAGCTTCCAGAATTTAAGAGTTTTGAGGAACTA GAACCTCCCAAACATTCAAAAGTCAAACGGCAAAGCAGCACCCCTAGTGCTCCTGAACTGGGACAGCAGCCGGATGTCAACATTAGTGAATGGAAGGACA AACCCACCCACGAAATTCTTCAAAAACTGAATGATTGCAGTTGTCTGGCTAGCCAAGCCATCCTGCTGGGTATACTGCTCAAAAGAGAAGGCCCCAACTT CATCACAAAGGAAGGTACCGTTTCTGATCACATTGAGAGAGTCTATAGAAGAGCTGGCAGCCAAAAACTTTGGTCGGTTGTACGCCGTGCAGCAAGTCTT TTAAGTAAAGTAGTGGACAGCCTGGCCCCATCCATTACTAATGTTTTAGTGCAGGGCAAACAGGTAACTCTGGGTGCCTTTGGGCATGAAGAAGAAGTTA TCTCTAATCCTTTGTCTCCAAGAGTGATTCAAAACATCATCTATTATAAGTGTAACACCCATGATGAGAGGGAAGCGGTCATTCAGCAAGAACTGGTCAT CCATATTGGCTGGATCATCTCCAATAACCCTGAGTTATTCAGTGGCATGCTGAAAATACGAATCGGGTGGATCATCCATGCCATGGAGTATGAACTTCAG ATCCGTGGCGGAGACAAGCCAGCCTTGGACTTGTATCAGCTGTCACCTAGTGAAGTTAAACAGCTTCTGCTGGATATTCTGCAGCCTCAACAGAATGGAA GATGTTGGCTGAACAGGCGTCAGATCGATGGGTCTTTGAATAGAACTCCCACCGGGTTCTATGACCGAGTGTGGCAGATTCTGGAGCGCACGCCCAATGG GATCATTGTTGCTGGGAAGCATTTGCCTCAGCAACCAACCCTGTCAGATATGACCATGTATGAGATGAATTTCTCTCTCCTTGTTGAAGACACGTTGGGA AATATTGACCAGCCACAGTACAGACAGATCGTTGTAGAGTTACTTATGGTTGTATCCATTGTACTGGAAAGAAACCCCGAGCTAGAATTTCAAGACAAAG TAGATCTAGACAGACTGGTCAAAGAAGCATTTAATGAATTTCAAAAAGATCAGAGTCGGCTAAAGGAAATTGAAAAACAAGATGACATGACTTCCTTTTA CAACACTCCTCCCCTGGGAAAAAGAGGAACATGCAGCTATTTGACAAAGGCGGTGATGAATCTGCTGCTGGAAGGAGAAGTCAAGCCAAACAATGATGAC CCGTGTCTGATTAGCTAGTGGGGAAGGTGTAGGAAGCTCTGTTGAGACACATGTTCTGAAGTGTGTTGTGTTTCATGTTCAAGCTTAATCAAGGCAGCCA TTAATATACGAACTGAGCATGCTGGGGAGGTGAATGCCACATCCTTGGCGGGGTTATGGACCTCTTGCATGTCATAGCCAATCTAACGGTAATGGTAAAT GCTTTTAATCAAGCAGGAAAAAGTTCTCATGATTATGCCAACTATAATAGTAATCCTCACTGAGTGATAAAAATAGTTTATGAATTGAAAATTTGCCGCT GCATGTTGTATGATCAAATAGTTCATCAAAATGAATCTTTGCTCTTTGGACTGAATTCTTACCATACTGCCATTAAAATAAATTTGCCAACTAGTAATGC ATACTGGAAATCAAAAGATACTGAAAGAATGGTGAACTTCTCTTAGTGGTATTGTCATGCTAAAAGATGTTAATATACATCATAAAAGCAAAGTCAGCCA GCTGATATTTTGGTTCTCAAAAACTGCATTATTAATAATATTTTAGTATACAGAGCTATTCTACAGTTTTTACATTGTAAACATGACTGTGGTTTTGTAT TTGCTAAATATAGGGGTTGGACTAAAATATAATAAATCTGTACCTTATCAAACATTTTCTTTGAGCTCCTGCTAAAAATAGGACATGTCTATGATTGTTC AAAAATATGTTAAATTTAGGCTCAGCACAGTAGCTCACACCTGAAATCTTAGCACTTCGGGAGGCTGAGGCAGGTGGATCACTTGAGGTTAGGAGTTCAA GACCAGCCCAGCCAACATGGTGAAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCAGGCATGATGGTGCATGCCTTTAAACCCAGCTACTGAGGAGG CTGAGGCATGAGAATTGCTTGAACCAGGAGACGGAGGTTGCAGTGAGCTGAAATCCTGCCACTGCACACCAGCCTGGGTGACAGAGCGAGACTCC

refseq_PHKB.F1 (forward primer)
refseq_PHKB.R1 (reverse primer)
Single exon skipping

Frame 0

GQGGDRSAMAGAAGLTAEVSWKVLERRARTKRS VLKLL*LSLRRL*LEPTI*NGLLT*CSRLSVFRF LKVWLSL*TS*KH*SSKT***NSLG*VGPLLQN CQVNIAAVSKSNYRSLSH*NMRW*PEGQDPGQP ILRCWGLGFGSCIQAN***QGKDP*AGALSYKMH ERNSLLLYASGR*GPAV*AGSTPNNMSSLCFQC AYRR*VAFL*GIWSSSDKCSVTLSPLPCGNDFL RTPDYLQH**GLFYSKPCILCGKSLPCA*LWCLG KRKQI**WQHRATFELGWFSKSSSRSN*WIQPF WQPGLFVVSYICGSRCSQSQQANFVLAVTQRIK IT*YRCCPAPLHQLSCICPG**SSF*PDT**SG* KIKRKIWI*TFLERWV*NIIGRSQQMLLQAS*N *AI*WH*M*ISHIFPLYDD*WSF*RQS*ASTGI SGSFDSSTSSYHRRISCCTKVLLCAS*LCRI*KK *PW*SKTIS*QLWP*WKTVSLGTSTLYHRKTPG **TY*S*RH*SCPALCPTKGST*REHEVFQSGP TGK*LGSSCGTYSRKPKTSSFSEHIWYSNSNSST SRTHSDMASAGACESLFAAGYQ*KVRTLWKARQ AHWLPRDIKDLSHSRKDCGLLPDYFRPK*FLHV SGCFPADR*HKECAAVH*TILENAWTSTFPCSHP GRQYKR*PVQPHIRYAGSP*KRNNWRSQSSCGS STDTNIWSCGRTT*FPTNQ*HRRASRI*EF*GT RTSQTFKSQTAKQHP*CS*TGTAAGCQH**MEGQ THPRNSSKTE*LQLSG*PSHPAGYTAQKRRPQL HHKGRYRF*SH*ESL*KSWQPKTLVGCTPCSKS FK*SSGQPGPIHY*CFSAGQTGNSGCLWA*RRSY L*SFVSKSDSKHHLL*V*HP**EGSGHSARTGH PYWLDHLQ*P*VIQWHAENTNRVDHPCHGV*TS DPWRRQASLGLVSAVT**S*TASAGYSAASTEWK MLAEQASDRWVFE*NSHRVL*PSVADSGAHAQW DHCCWEAFASATNPVRYDHV*DEFLSPC*RHVG KY*PATVQTDRCRVTYGCIHCTGKKPRARISRQS RSRQTGQRSI**ISKRSESAKGN*KTR*HDFLL QHSSPGKKRNMQLFDKGGDESAAGRRSQAKQ** PVSD*LVGKV*EALLRHMF*SVLCFMFKLNQGSH *YTN*ACWGGECHILGGVMDLLHVIANLTVMVN AFNQAGKSSHDYANYNSNPH*VIKIVYELKICR CMLYDQIVHQNESLLFGLNSYHTAIKINLPTSNA YWKSKDTERMVNFS*WYCHAKRC*YTS*KQSQP ADILVLKNCIINNILVYRAILQFLHCKHDCGFV FAKYRGWTKI**ICTLSNIFFELLLKIGHVYDCS KIC*I*AQHSSSHLKS*HFGRLRQVDHLRLGVQ DQPSQHGENPVSTKNTKISQA*WCMPLNPATEE AEA*ELLEPGDGGCSELKSCHCTPAWVTERDS

Frame 1

AKAATGARWRGRRDSRQK*AGRSWSEELGPSAQ F*NCYSLACDAYD*SQQFEMACSPDAVVSPSSA FLRSGSVYEPLKSINLPRPDNETLWDKLDHYYRI VKSTLLLYQSPTTGLFPTKTCGGDQKAKIQDSL YCAAGAWALALAYRRIDDDKGRTHELEHSAIKC MRGILYCYMRQADKVQQFKQDPRPTTCLHSVFNV HTGDELLSYEEYGHLQINAVSLYLLYLVEMISS GLQIIYNTDEVSFIQNLVFCVERVYRVPDFGVW ERGSKYNNGSTELHSSSVGLAKAALEAINGFNLF GNQGCSWSVIFVDLDAHNRNRQTLCSLLPRESR SHNTDAALLPCISYPAFALDDEVLFSQTLDKVV RKLKGKYGFKRFLRDGYRTSLEDPNRCYYKPAEI KLFDGIECEFPIFFLYMMIDGVFRGNPKQVQEY QDLLTPVLHHTTEGYPVVPKYYYVPADFVEYEK NNPGSQKRFPSNCGRDGKLFLWGQALYIIAKLLA DELISPKDIDPVQRYVPLKDQRNVSMRFSNQGP LENDLVVHVALIAESQRLQVFLNTYGIQTQTPQ QVEPIQIWPQQELVKAYLQLGINEKLGLSGRPDR PIGCLGTSKIYRILGKTVVCYPIIFDLSDFYMS QDVFLLIDDIKNALQFIKQYWKMHGRPLFLVLI REDNIRGSRFNPILDMLAALKKGIIGGVKVHVDR LQTLISGAVVEQLDFLRISDTEELPEFKSFEEL EPPKHSKVKRQSSTPSAPELGQQPDVNISEWKD KPTHEILQKLNDCSCLASQAILLGILLKREGPNF ITKEGTVSDHIERVYRRAGSQKLWSVVRRAASL LSKVVDSLAPSITNVLVQGKQVTLGAFGHEEEV ISNPLSPRVIQNIIYYKCNTHDEREAVIQQELVI HIGWIISNNPELFSGMLKIRIGWIIHAMEYELQ IRGGDKPALDLYQLSPSEVKQLLLDILQPQQNG RCWLNRRQIDGSLNRTPTGFYDRVWQILERTPNG IIVAGKHLPQQPTLSDMTMYEMNFSLLVEDTLG NIDQPQYRQIVVELLMVVSIVLERNPELEFQDK VDLDRLVKEAFNEFQKDQSRLKEIEKQDDMTSFY NTPPLGKRGTCSYLTKAVMNLLLEGEVKPNNDD PCLIS*WGRCRKLC*DTCSEVCCVSCSSLIKAA INIRTEHAGEVNATSLAGLWTSCMS*PI*R*W*M LLIKQEKVLMIMPTIIVILTE**K*FMN*KFAA ACCMIK*FIKMNLCSLD*ILTILPLK*ICQLVM HTGNQKILKEW*TSLSGIVMLKDVNIHHKSKVSQ LIFWFSKTALLIIF*YTELFYSFYIVNMTVVLY LLNIGVGLKYNKSVPYQTFSLSSC*K*DMSMIV QKYVKFRLSTVAHT*NLSTSGG*GRWIT*G*EFK TSPANMVKTLSLLKIQKLARHDGACL*TQLLRR LRHENCLNQETEVAVS*NPATAHQPG*QSET

Frame 2

PRRRPERDGGGGGTHGRSELEGLGAKSSDQALS FKIAIA*PATLMIRANNLKWPAHLMQSSLRLPL S*GLAQFMNLLKALIFQDLIMKLSGISWTIITE LSSQHCCCIKVQLPVSFPLKHAVVTRRPRSRTAY TALLGPGLWLLHTGELMMTREGPMSWSTQL*NA *EEFSTAICVRPIRSSSLSRIHAQQHVFTLFSM CIQEMSCFPMRNMVIFR*MQCHFISFTLWK*FPQ DSRLSTTLMRSLLFKTLYFVWKEFTVCLTLVSG KEEANIIMAAQSYIRARLV*QKQL*KQLMDSTF LATRAVRGQLYLWISMLTIATGKLCARCYPENQD HIIQMLPCSPASVILHLPWMMKFFLARHLIKWL EN*KENMDLNVS*EMGIEHHWKIPTDATTSQLK LSYLMALNVNFPYFSFI**LMEFLEAILSKYRNI RIF*LQYFIIPQKDILLYQSTIMCQLTL*NMKK ITLVVKNDFLATVAVMENCFFGDKHFISSQNSW LMNLLVLKTLILSSAMSH*RINVT*A*GFPIRAH WKMTW*FMWHL*QKAKDFKFF*THMVFKLKLLN K*NPFRYGLSRSL*KLICSWVSMKS*DSLEGQT GPLAASGHQRFIAF*ERLWFVTRLFST*VISTCL RMFSC**MT*RMRCSSLNNIGKCMDVHFSLFSS GKTI*EVAGSTPY*ICWQPLKKE*LEESKFMWI VYRH*YLELW*NNLISYESVTQKSFQNLRVLRN* NLPNIQKSNGKAAPLVLLNWDSSRMSTLVNGRT NPPTKFFKN*MIAVVWLAKPSCWVYCSKEKAPT SSQRKVPFLITLRESIEELAAKNFGRLYAVQQVF *VK*WTAWPHPLLMF*CRANR*LWVPLGMKKKL SLILCLQE*FKTSSIISVTPMMRGKRSFSKNWS SILAGSSPITLSYSVAC*KYESGGSSMPWSMNFR SVAETSQPWTCISCHLVKLNSFCWIFCSLNRME DVG*TGVRSMGL*IELPPGSMTECGRFWSARPM GSLLLGSICLSNQPCQI*PCMR*ISLSLLKTRWE ILTSHSTDRSL*SYLWLYPLYWKETPS*NFKTK *I*TDWSKKHLMNFKKIRVG*RKLKNKMT*LPF TTLLPWEKEEHAAI*QRR**ICCWKEKSSQTMMT RV*LASGEGVGSSVETHVLKCVVFHVQA*SRQP LIYELSMLGR*MPHPWRGYGPLACHSQSNGNGK CF*SSRKKFS*LCQL***SSLSDKNSL*IENLPL HVV*SNSSSK*IFALWTEFLPYCH*NKFAN**C ILEIKRY*KNGELLLVVLSC*KMLIYIIKAKSA S*YFGSQKLHY**YFSIQSYSTVFTL*T*LWFCI C*I*GLD*NIINLYLIKHFL*APAKNRTCL*LF KNMLNLGSAQ*LTPEILALREAEAGGSLEVRSS RPAQPTW*KPCLY*KYKN*PGMMVHAFKPSY*GG *GMRIA*TRRRRLQ*AEILPLHTSLGDRARL