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Sequences

Sequence NM_003174

TCGGCGGGAAGCGGCGATCCTGCCACCGGGAGGTGTGGAAGAGCCGGGTAGATTCTGGCTACATTGGAGATTGGTTGCTTTCTAAAACTGAAGGAGAAGC CCATGAAGAGATGGTGGATTCTCACTGAGTTTTGACTAGCGGAAGAAAAGAGAGAGTTCAAGTGGATGGCCTTGAGGACTTGAAAAGCTGAGATATGATG ATTTTGAAGTCATTTCACATCGAAGCCATGATTTAAATATCGGCGTTAAGATTTCAACAAGAAAAACTTAAGCTTCCTTGGATTCCCACGTCAAAGGAAA GTTTCAAGCTTTCAGAAGGAGTTCTCACTCGAAGATAAAGAACAGCTCGCTAACCACGAAAGAGGAATCGATGCTCAGCTTTTAGTTGCACTTCCTAAAG TTGCAGAATTAAGACAAATCTTTGAACCAAAGAAGAAAGAATTCTTAGAAATGAAAAGAAAAGAAAGAATTGCCAGGCGCCTGGAAGGGATTGAAAATGA CACTCAGCCCATCCTCTTGCAGAGCTGCACAGGATTGGTGACTCACCGCCTGCTGGAGGAAGACACCCCTCGATACATGAGAGCCAGCGACCCTGCCAGC CCCCACATCGGCCGATCAAATGAAGAGGAGGAAACTTCTGATTCTTCTCTAGAAAAGCAAACTCGATCCAAATACTGCACAGAAACCTCCGGTGTCCACG GTGACTCACCCTATGGTTCGGGTACCATGGACACCCACAGTCTGGAGTCCAAAGCCGAAAGAATTGCAAGGTACAAAGCAGAAAGAAGGCGACAGCTGGC AGAGAAGTATGGGCTGACTCTGGATCCCGAGGCCGACTCCGAGTATTTATCCCGCTATACCAAGTCCAGGAAGGAGCCTGATGCTGTCGAGAAGCGGGGA GGAAAAAGTGACAAACAGGAAGAGTCAAGCAGAGATGCTAGTTCTCTGTACCCCGGGACCGAGACGATGGGGCTCAGGACCTGTGCCGGTGAATCCAAGG ACTATGCCCTCCATGTGGGTGACGGCTCTTCCGACCCGGAGGTGCTGCTGAACATAGAAAACCAAAGACGAGGTCAAGAGCTGAGTGCCACCCGGCAGGC CCATGACCTGTCCCCAGCAGCCGAGAGTTCCTCGACCTTCTCTTTCTCTGGGCGAGACTCCTCCTTCACTGAAGTGCCACGGTCCCCCAAGCACGCCCAC AGCTCCTCCCTGCAGCAGGCAGCCTCCCGGAGCCCCTCCTTTGGTGACCCACAGCTATCCCCTGAGGCCCGACCCAGGTGCACTTCACATTCAGAAACGC CAACTGTCGATGATGAAGAAAAGGTGGATGAACGAGCCAAGCTGAGCGTCGCCGCCAAGAGGTTGCTTTTCAGGGAGATGGAAAAATCTTTTGATGAACA AAATGTTCCAAAGCGACGCTCAAGAAACACAGCTGTGGAGCAGAGGCTACGCCGTCTGCAGGACAGGTCCCTCACCCAGCCCATCACCACTGAAGAGGTG GTCATCGCAGCCACATTGCAGGCCTCTGCTCACCAAAAGGCCTTAGCCAAGGACCAGACAAATGAGGGCAAAGAGCTTGCTGAGCAAGGAGAACCTGATT CCTCCACTCTAAGCTTGGCCGAAAAGTTGGCCTTGTTTAACAAATTGTCCCAGCCAGTCTCAAAAGCGATTTCTACCCGGAACAGAATAGACACGAGACA GAGGAGAATGAACGCTCGCTATCAAACTCAGCCAGTCACACTGGGAGAGGTGGAGCAGGTGCAGAGTGGAAAGCTCATTCCTTTCTCACCTGCCGTGAAC ACATCAGTGTCTACCGTAGCATCCACGGTTGCTCCAATGTATGCCGGAGATCTTCGCACAAAGCCACCTCTTGACCACAATGCAAGTGCCACTGACTATA AGTTTTCTTCTTCAATAGAAAATTCGGACTCTCCAGTTAGAAGCATTCTGAAATCGCAAGCTTGGCAGCCTTTGGTAGAGGGTAGCGAGAACAAGGGAAT GTTGAGAGAATATGGAGAGACAGAAAGCAAGAGAGCTTTGACAGGTCGAGACAGTGGGATGGAGAAGTATGGGTCCTTTGAGGAAGCAGAAGCATCCTAC CCCATCCTGAACCGAGCCAGGGAAGGAGACAGCCATAAGGAATCTAAATATGCTGTTCCCAGAAGAGGAAGCCTGGAACGGGCGAACCCTCCCATCACCC ACCTCGGGGATGAACCGAAGGAATTTTCCATGGCTAAAATGAATGCACAAGGAAACTTGGACTTGAGGGACAGGCTGCCCTTTGAAGAGAAGGTGGAGGT GGAGAATGTTATGAAAAGGAAGTTTTCACTAAGAGCGGCAGAGTTCGGGGAGCCCACTTCCGAGCAGACGGGGACAGCTGCTGGGAAAACTATTGCTCAA ACCACAGCCCCCGTGTCCTGGAAGCCCCAGGATTCTTCGGAACAGCCACAGGAGAAGCTCTGCAAGAATCCATGTGCGATGTTTGCTGCTGGAGAGATCA AAACGCCGACAGGGGAGGGCCTTCTTGACTCACCCAGCAAAACCATGTCTATTAAAGAAAGATTGGCACTGTTGAAGAAAAGCGGGGAGGAAGATTGGAG AAACAGACTCAGCAGGAGGCAGGAGGGCGGCAAGGCGCCGGCCAGCAGCCTGCACACCCAGGAAGCAGGGCGGTCCCTCATCAAGAAGCGGGTCACAGAA AGTCGAGAGAGCCAAATGACGATTGAGGAGAGGAAGCAGCTCATCACTGTGAGAGAGGAGGCCTGGAAGACGAGAGGCAGAGGAGCGGCCAACGACTCGA CCCAGTTCACTGTGGCTGGCAGGATGGTGAAGAAAGGTTTGGCGTCACCTACTGCCATAACCCCAGTAGCCTCACCCATTTGCGGTAAAACAAGAGGCAC CACACCCGTTTCCAAACCCCTGGAAGATATCGAAGCCAGACCAGATATGCAGTTAGAATCGGACCTGAAGTTGGACAGGCTGGAAACCTTTCTAAGAAGG CTGAATAACAAAGTTGGCGGGATGCACGAAACGGTGCTCACTGTCACCGGCAAATCTGTGAAGGAGGTGATGAAGCCAGATGATGATGAAACCTTTGCCA AATTTTACCGCAGCGTGGATTATAATATGCCAAGAAGTCCTGTGGAGATGGATGAGGACTTCGATGTCATTTTCGATCCTTATGCACCCAAATTGACGTC TTCCGTGGCCGAGCACAAGCGGGCAGTTAGGCCCAAGCGCCGGGTTCAGGCCTCCAAAAACCCCCTGAAAATGCTGGCGGCAAGAGAAGATCTCCTTCAG GAATACACTGAGCAGAGATTAAACGTTGCCTTCATGGAGTCAAAGCGGATGAAAGTAGAAAAGATGTCTTCCAACTCCAACTTCTCAGAAGTCACCCTGG CGGGTTTAGCCAGTAAAGAAAACTTCAGCAACGTCAGCCTGCGGAGCGTCAACCTGACGGAACAGAACTCTAACAACAGCGCCGTGCCCTACAAGAGGCT GATGCTGTTGCAGATTAAAGGAAGAAGACATGTGCAGACCAGGCTGGTGGAACCTCGAGCTTCGGCGCTCAACAGTGGGGACTGCTTCCTCCTGCTCTCT CCCCACTGCTGCTTCCTGTGGGTAGGAGAGTTTGCAAACGTCATAGAAAAGGCGAAGGCCTCAGAACTTGCAACTTTAATTCAGACAAAGAGGGAACTTG GTTGTAGAGCTACTTATATCCAAACCATTGAAGAAGGAATTAATACACACACTCATGCAGCCAAAGACTTCTGGAAGCTTCTGGGTGGCCAAACCAGTTA CCAATCTGCTGGAGACCCAAAAGAAGATGAACTCTATGAAGCAGCCATAATAGAAACTAACTGCATTTACCGTCTCATGGATGACAAACTTGTTCCTGAT GACGACTACTGGGGGAAAATTCCGAAGTGCTCCCTTCTGCAACCCAAAGAGGTACTGGTGTTTGATTTTGGTAGTGAAGTTTACGTATGGCATGGGAAAG AAGTCACATTAGCACAACGAAAAATAGCATTTCAGCTGGCAAAGCACTTATGGAATGGAACCTTTGACTATGAGAACTGTGACATCAATCCCCTGGATCC TGGAGAATGCAATCCGCTTATCCCCAGAAAAGGACAGGGGCGGCCCGACTGGGCGATATTTGGGAGACTTACTGAACACAATGAGACGATTTTGTTCAAA GAGAAGTTTCTGGATTGGACGGAACTGAAGAGATCGAATGAGAAGAACCCCGGGGAACTTGCCCAGCACAAGGAAGACCCCAGGACTGATGTCAAGGCAT ACGATGTGACACGGATGGTGTCCATGCCCCAGACGACAGCAGGCACCATCCTGGACGGAGTGAACGTCGGCCGTGGCTATGGCCTGGTGGAAGGACACGA CAGGAGGCAGTTTGAGATCACCAGCGTTTCCGTGGATGTCTGGCACATCCTGGAATTCGACTATAGCAGGCTCCCCAAACAAAGCATCGGGCAGTTCCAT GAGGGGGATGCCTATGTGGTCAAGTGGAAGTTCATGGTGAGCACGGCAGTGGGAAGTCGCCAGAAGGGAGAGCACTCGGTGAGGGCAGCCGGCAAAGAGA AGTGCGTCTACTTCTTCTGGCAAGGCCGGCACTCCACCGTGAGTGAGAAGGGCACGTCGGCGCTGATGACGGTGGAGCTGGACGAGGAAAGGGGGGCCCA GGTCCAGGTTCTCCAGGGAAAGGAGCCCCCCTGTTTCCTGCAGTGTTTCCAGGGGGGGATGGTGGTGCACTCGGGGAGGCGGGAAGAGGAAGAAGAAAAT GTGCAAAGTGAGTGGCGGCTGTACTGCGTGCGTGGAGAGGTGCCCGTGGAAGGGAATTTGCTGGAAGTGGCCTGTCACTGTAGCAGCCTGAGGTCCAGAA CTTCCATGGTGGTGCTTAACGTCAACAAGGCCCTCATCTACCTGTGGCACGGATGCAAAGCCCAGGCCCACACGAAGGAGGTCGGAAGGACCGCTGCGAA CAAGATCAAGGAACAATGTCCCCTGGAAGCAGGACTGCATAGTAGCAGCAAAGTCACAATACACGAGTGTGATGAAGGCTCCGAGCCACTCGGATTCTGG GATGCCTTAGGAAGGAGAGACAGGAAAGCCTACGATTGCATGCTTCAAGATCCTGGAAGTTTTAACTTCGCGCCCCGCCTGTTCATCCTCAGCAGCTCCT CTGGGGATTTTGCAGCCACAGAGTTTGTGTACCCTGCCCGAGCCCCCTCTGTGGTCAGTTCCATGCCCTTCCTGCAGGAAGATCTGTACAGCGCGCCCCA GCCAGCACTTTTCCTTGTTGACAATCACCACGAGGTGTACCTCTGGCAAGGCTGGTGGCCCATCGAGAACAAGATCACTGGTTCCGCCCGCATCCGCTGG GCCTCCGACCGGAAGAGTGCGATGGAGACTGTGCTCCAGTACTGCAAAGGAAAAAATCTCAAGAAACCAGCCCCCAAGTCTTACCTTATCCACGCTGGTC TGGAGCCCCTGACATTCACCAATATGTTTCCCAGCTGGGAGCACAGAGAGGACATCGCTGAGATCACAGAGATGGACACGGAAGTTTCCAATCAGATCAC CCTCGTGGAAGACGTCTTAGCCAAGCTCTGTAAAACCATTTACCCGCTGGCCGACCTCCTGGCCAGGCCACTCCCGGAGGGGGTCGATCCTCTGAAGCTT GAGATCTATCTCACCGACGAAGACTTCGAGTTTGCACTAGACATGACGAGGGATGAATACAACGCCCTGCCCGCCTGGAAGCAGGTGAACCTGAAGAAAG CAAAAGGCCTGTTCTGAGTGGGGAGACGCCAGAGGAGCCTCACGGTCACGTCCAACAACACCACTGCACCAGGGAAATGGATATATATTTTTGGACTGGT GTTTTTCACAAAGTATTTTTCAATCAGAGTTTTCAGAACCTGACATTGTTAAAGATACTGCTTGTCCCGGAGTTGTGTATTTTGTAAATGTTCAAGGGAA CTGTTTGGAAACTTCTTTCCACCATTCAGGAGGTTATCAGAATTAATAAAAGTATCTGTTATGTGCACTTAAGCCGCAGCTGCTATAGATAGCACTGCCT TCTTGTTCCAGCTAGGCAATGCCTTTTTTTTTTTTTTTTGAAGCAGTTCTCTTTATAAAGTGTTATTTTGATAGTTTGTGGATTCTAAAATATATATATA TTTATATAAACACCATATAAGTCAAATATGTATTTAACAAAGCAATATGTATTCATTCACTTTCAAGATTTGTTTTGGTGTCAAAATAACATGAAAAGGT AGATGGAGTTGCTTCTGTTGAATTAGCTCTGCCACCAATATGTATCTTCATACACGTTTGGAAATGTTTCCTGCAGCATTAGGTATGACTTGTTCTGAGT ACTGCTTCCGGTGCTAAAATGAACAAAGAATTTGTACTTAATGGCATGGACTCTGGAGAATCTATGCGAATCAACCTTTCTACCTTAATATCTCCCCAAA AATGTATAGTGCCTTGTTTTTATGTACAGTTTATATACAGAAAAGTTTGCTCTGCATTTTTGATGATGGTTTGGAACATTATCTACAATTTTACTCTCAA ATAGTCAAAATAAAAACATCTCAATTTCTAATACCGGTTGTAAACAGTACACATGTCATTTTGTGATATAGGACTCCCAAATAAAAGTATCAGAATAAAC ACAACAATTAACTGGT

refseq_SVIL.F1 (forward primer)
refseq_SVIL.R1 (reverse primer)
Single exon skipping

Frame 0

SAGSGDPATGRCGRAG*ILATLEIGCFLKLKEK PMKRWWILTEF*LAEEKREFKWMALRT*KAEI** F*SHFTSKP*FKYRR*DFNKKNLSFLGFPRQRK VSSFQKEFSLEDKEQLANHERGIDAQLLVALPK VAELRQIFEPKKKEFLEMKRKERIARRLEGIEND TQPILLQSCTGLVTHRLLEEDTPRYMRASDPAS PHIGRSNEEEETSDSSLEKQTRSKYCTETSGVH GDSPYGSGTMDTHSLESKAERIARYKAERRRQLA EKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRG GKSDKQEESSRDASSLYPGTETMGLRTCAGESK DYALHVGDGSSDPEVLLNIENQRRGQELSATRQA HDLSPAAESSSTFSFSGRDSSFTEVPRSPKHAH SSSLQQAASRSPSFGDPQLSPEARPRCTSHSET PTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQ NVPKRRSRNTAVEQRLRRLQDRSLTQPITTEEV VIAATLQASAHQKALAKDQTNEGKELAEQGEPD SSTLSLAEKLALFNKLSQPVSKAISTRNRIDTRQ RRMNARYQTQPVTLGEVEQVQSGKLIPFSPAVN TSVSTVASTVAPMYAGDLRTKPPLDHNASATDY KFSSSIENSDSPVRSILKSQAWQPLVEGSENKGM LREYGETESKRALTGRDSGMEKYGSFEEAEASY PILNRAREGDSHKESKYAVPRRGSLERANPPIT HLGDEPKEFSMAKMNAQGNLDLRDRLPFEEKVEV ENVMKRKFSLRAAEFGEPTSEQTGTAAGKTIAQ TTAPVSWKPQDSSEQPQEKLCKNPCAMFAAGEI KTPTGEGLLDSPSKTMSIKERLALLKKSGEEDWR NRLSRRQEGGKAPASSLHTQEAGRSLIKKRVTE SRESQMTIEERKQLITVREEAWKTRGRGAANDS TQFTVAGRMVKKGLASPTAITPVASPICGKTRGT TPVSKPLEDIEARPDMQLESDLKLDRLETFLRR LNNKVGGMHETVLTVTGKSVKEVMKPDDDETFA KFYRSVDYNMPRSPVEMDEDFDVIFDPYAPKLTS SVAEHKRAVRPKRRVQASKNPLKMLAAREDLLQ EYTEQRLNVAFMESKRMKVEKMSSNSNFSEVTL AGLASKENFSNVSLRSVNLTEQNSNNSAVPYKRL MLLQIKGRRHVQTRLVEPRASALNSGDCFLLLS PHCCFLWVGEFANVIEKAKASELATLIQTKREL GCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSY QSAGDPKEDELYEAAIIETNCIYRLMDDKLVPD DDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGK EVTLAQRKIAFQLAKHLWNGTFDYENCDINPLDP GECNPLIPRKGQGRPDWAIFGRLTEHNETILFK EKFLDWTELKRSNEKNPGELAQHKEDPRTDVKA YDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGHD RRQFEITSVSVDVWHILEFDYSRLPKQSIGQFH EGDAYVVKWKFMVSTAVGSRQKGEHSVRAAGKE KCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQ VQVLQGKEPPCFLQCFQGGMVVHSGRREEEEEN VQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSR TSMVVLNVNKALIYLWHGCKAQAHTKEVGRTAAN KIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFW DALGRRDRKAYDCMLQDPGSFNFAPRLFILSSS SGDFAATEFVYPARAPSVVSSMPFLQEDLYSAPQ PALFLVDNHHEVYLWQGWWPIENKITGSARIRW ASDRKSAMETVLQYCKGKNLKKPAPKSYLIHAG LEPLTFTNMFPSWEHREDIAEITEMDTEVSNQIT LVEDVLAKLCKTIYPLADLLARPLPEGVDPLKL EIYLTDEDFEFALDMTRDEYNALPAWKQVNLKK AKGLF*VGRRQRSLTVTSNNTTAPGKWIYIFGLV FFTKYFSIRVFRT*HC*RYCLSRSCVFCKCSRE LFGNFFPPFRRLSELIKVSVMCT*AAAAIDSTA FLFQLGNAFFFFF*SSSLYKVLF**FVDSKIYIY LYKHHISQICI*QSNMYSFTFKICFGVKIT*KG RWSCFC*ISSATNMYLHTRLEMFPAALGMTCSE YCFRC*NEQRICT*WHGLWRIYANQPFYLNISPK MYSALFLCTVYIQKSLLCIFDDGLEHYLQFYSQ IVKIKTSQFLIPVVNSTHVIL*YRTPK*KYQNK HNN*L

Frame 1

RREAAILPPGGVEEPGRFWLHWRLVAF*N*RRS P*RDGGFSLSFD*RKKRESSSGWP*GLEKLRYD DFEVISHRSHDLNIGVKISTRKT*ASLDSHVKGK FQAFRRSSHSKIKNSSLTTKEESMLSF*LHFLK LQN*DKSLNQRRKNS*K*KEKKELPGAWKGLKM TLSPSSCRAAQDW*LTACWRKTPLDT*EPATLPA PTSADQMKRRKLLILL*KSKLDPNTAQKPPVST VTHPMVRVPWTPTVWSPKPKELQGTKQKEGDSW QRSMG*LWIPRPTPSIYPAIPSPGRSLMLSRSGE EKVTNRKSQAEMLVLCTPGPRRWGSGPVPVNPR TMPSMWVTALPTRRCC*T*KTKDEVKS*VPPGR PMTCPQQPRVPRPSLSLGETPPSLKCHGPPSTPT APPCSRQPPGAPPLVTHSYPLRPDPGALHIQKR QLSMMKKRWMNEPS*ASPPRGCFSGRWKNLLMN KMFQSDAQETQLWSRGYAVCRTGPSPSPSPLKRW SSQPHCRPLLTKRP*PRTRQMRAKSLLSKENLI PPL*AWPKSWPCLTNCPSQSQKRFLPGTE*TRD RGE*TLAIKLSQSHWERWSRCRVESSFLSHLP*T HQCLP*HPRLLQCMPEIFAQSHLLTTMQVPLTI SFLLQ*KIRTLQLEAF*NRKLGSLW*RVARTRE C*ENMERQKAREL*QVETVGWRSMGPLRKQKHPT PS*TEPGKETAIRNLNMLFPEEEAWNGRTLPSP TSGMNRRNFPWLK*MHKETWT*GTGCPLKRRWR WRML*KGSFH*ERQSSGSPLPSRRGQLLGKLLLK PQPPCPGSPRILRNSHRRSSARIHVRCLLLERS KRRQGRAFLTHPAKPCLLKKDWHC*RKAGRKIG ETDSAGGRRAARRRPAACTPRKQGGPSSRSGSQK VERAK*RLRRGSSSSL*ERRPGRREAEERPTTR PSSLWLAGW*RKVWRHLLP*PQ*PHPFAVKQEA PHPFPNPWKISKPDQICS*NRT*SWTGWKPF*EG *ITKLAGCTKRCSLSPANL*RR**SQMMMKPLP NFTAAWIIICQEVLWRWMRTSMSFSILMHPN*R LPWPSTSGQLGPSAGFRPPKTP*KCWRQEKISFR NTLSRD*TLPSWSQSG*K*KRCLPTPTSQKSPW RV*PVKKTSATSACGAST*RNRTLTTAPCPTRG *CCCRLKEEDMCRPGWWNLELRRSTVGTASSCSL PTAASCG*ESLQTS*KRRRPQNLQL*FRQRGNL VVELLISKPLKKELIHTLMQPKTSGSFWVAKPV TNLLETQKKMNSMKQP**KLTAFTVSWMTNLFLM TTTGGKFRSAPFCNPKRYWCLILVVKFTYGMGK KSH*HNEK*HFSWQSTYGMEPLTMRTVTSIPWI LENAIRLSPEKDRGGPTGRYLGDLLNTMRRFCSK RSFWIGRN*RDRMRRTPGNLPSTRKTPGLMSRH TM*HGWCPCPRRQQAPSWTE*TSAVAMAWWKDT TGGSLRSPAFPWMSGTSWNSTIAGSPNKASGSSM RGMPMWSSGSSW*ARQWEVARRESTR*GQPAKR SASTSSGKAGTPP*VRRARRR**RWSWTRKGGP RSRFSRERSPPVSCSVSRGGWWCTRGGGKRKKKM CKVSGGCTACVERCPWKGICWKWPVTVAA*GPE LPWWCLTSTRPSSTCGTDAKPRPTRRRSEGPLR TRSRNNVPWKQDCIVAAKSQYTSVMKAPSHSDSG MP*EGETGKPTIACFKILEVLTSRPACSSSAAP LGILQPQSLCTLPEPPLWSVPCPSCRKICTARP SQHFSLLTITTRCTSGKAGGPSRTRSLVPPASAG PPTGRVRWRLCSSTAKEKISRNQPPSLTLSTLV WSP*HSPICFPAGSTERTSLRSQRWTRKFPIRS PSWKTS*PSSVKPFTRWPTSWPGHSRRGSIL*SL RSISPTKTSSLH*T*RGMNTTPCPPGSR*T*RK QKACSEWGDARGASRSRPTTPLHQGNGYIFLDW CFSQSIFQSEFSEPDIVKDTACPGVVYFVNVQGN CLETSFHHSGGYQN**KYLLCALKPQLL*IALP SCSS*AMPFFFFFEAVLFIKCYFDSLWILKYIY IYINTI*VKYVFNKAICIHSLSRFVLVSK*HEKV DGVASVELALPPICIFIHVWKCFLQH*V*LVLS TASGAKMNKEFVLNGMDSGESMRINLSTLISPQ KCIVPCFYVQFIYRKVCSAFLMMVWNIIYNFTLK *SK*KHLNF*YRL*TVHMSFCDIGLPNKSIRIN TTINW

Frame 2

GGKRRSCHREVWKSRVDSGYIGDWLLSKTEGEA HEEMVDSH*VLTSGRKERVQVDGLEDLKS*DMM ILKSFHIEAMI*ISALRFQQEKLKLPWIPTSKE SFKLSEGVLTRR*RTAR*PRKRNRCSAFSCTS*S CRIKTNL*TKEERILRNEKKRKNCQAPGRD*K* HSAHPLAELHRIGDSPPAGGRHPSIHESQRPCQ PPHRPIK*RGGNF*FFSRKANSIQILHRNLRCPR *LTLWFGYHGHPQSGVQSRKNCKVQSRKKATAG REVWADSGSRGRLRVFIPLYQVQEGA*CCREAG RKK*QTGRVKQRC*FSVPRDRDDGAQDLCR*IQG LCPPCG*RLFRPGGAAEHRKPKTRSRAECHPAG P*PVPSSREFLDLLFLWARLLLH*SATVPQARP QLLPAAGSLPEPLLW*PTAIP*GPTQVHFTFRNA NCR**RKGG*TSQAERRRQEVAFQGDGKIF**T KCSKATLKKHSCGAEATPSAGQVPHPAHHH*RG GHRSHIAGLCSPKGLSQGPDK*GQRAC*ARRT*F LHSKLGRKVGLV*QIVPASLKSDFYPEQNRHET EENERSLSNSASHTGRGGAGAEWKAHSFLTCRE HISVYRSIHGCSNVCRRSSHKATS*PQCKCH*L* VFFFNRKFGLSS*KHSEIASLAAFGRG*REQGN VERIWRDRKQESFDRSRQWDGEVWVL*GSRSIL PHPEPSQGRRQP*GI*ICCSQKRKPGTGEPSHHP PRG*TEGIFHG*NECTRKLGLEGQAAL*REGGG GECYEKEVFTKSGRVRGAHFRADGDSCWENYCS NHSPRVLEAPGFFGTATGEALQESMCDVCCWRDQ NADRGGPS*LTQQNHVY*RKIGTVEEKRGGRLE KQTQQEAGGRQGAGQQPAHPGSRAVPHQEAGHR KSREPNDD*GEEAAHHCERGGLEDERQRSGQRLD PVHCGWQDGEERFGVTYCHNPSSLTHLR*NKRH HTRFQTPGRYRSQTRYAVRIGPEVGQAGNLSKK AE*QSWRDARNGAHCHRQICEGGDEAR***NLCQ ILPQRGL*YAKKSCGDG*GLRCHFRSLCTQIDV FRGRAQAGS*AQAPGSGLQKPPENAGGKRRSPS GIH*AEIKRCLHGVKADESRKDVFQLQLLRSHPG GFSQ*RKLQQRQPAERQPDGTEL*QQRRALQEA DAVAD*RKKTCADQAGGTSSFGAQQWGLLPPAL SPLLLPVGRRVCKRHRKGEGLRTCNFNSDKEGTW L*SYLYPNH*RRN*YTHSCSQRLLEASGWPNQL PICWRPKRR*TL*SSHNRN*LHLPSHG*QTCS* *RLLGENSEVLPSATQRGTGV*FW**SLRMAWER SHISTTKNSISAGKALMEWNL*L*EL*HQSPGS WRMQSAYPQKRTGAARLGDIWETY*TQ*DDFVQ REVSGLDGTEEIE*EEPRGTCPAQGRPQD*CQGI RCDTDGVHAPDDSRHHPGRSERRPWLWPGGRTR QEAV*DHQRFRGCLAHPGIRL*QAPQTKHRAVP *GGCLCGQVEVHGEHGSGKSPEGRALGEGSRQRE VRLLLLARPALHRE*EGHVGADDGGAGRGKGGP GPGSPGKGAPLFPAVFPGGDGGALGEAGRGRRK CAK*VAAVLRAWRGARGREFAGSGLSL*QPEVQN FHGGA*RQQGPHLPVARMQSPGPHEGGRKDRCE QDQGTMSPGSRTA**QQSHNTRV**RLRATRIL GCLRKERQESLRLHASRSWKF*LRAPPVHPQQLL WGFCSHRVCVPCPSPLCGQFHALPAGRSVQRAP ASTFPC*QSPRGVPLARLVAHREQDHWFRPHPL GLRPEECDGDCAPVLQRKKSQETSPQVLPYPRWS GAPDIHQYVSQLGAQRGHR*DHRDGHGSFQSDH PRGRRLSQAL*NHLPAGRPPGQATPGGGRSSEA *DLSHRRRLRVCTRHDEG*IQRPARLEAGEPEES KRPVLSGETPEEPHGHVQQHHCTREMDIYFWTG VFHKVFFNQSFQNLTLLKILLVPELCIL*MFKG TVWKLLSTIQEVIRINKSICYVHLSRSCYR*HCL LVPARQCLFFFFLKQFSL*SVILIVCGF*NIYI FI*TPYKSNMYLTKQYVFIHFQDLFWCQNNMKR *MELLLLN*LCHQYVSSYTFGNVSCSIRYDLF*V LLPVLK*TKNLYLMAWTLENLCESTFLP*YLPK NV*CLVFMYSLYTEKFALHF**WFGTLSTILLS NSQNKNISISNTGCKQYTCHFVI*DSQIKVSE*T QQLTG

Sequence NM_021738

CACTGCTCTGACTGCGTCCTCCCCAGGCTGAAGTGTCCTCAGGTTTCATGTGGATTTGCCCAGTAATGGATGGCTCCACCGAGGCCAGGTTGGGGAAGTT CAGCCTCGAGGACACTAGGGGACGAAAAACTTCAAAAAGAAGACTCTTTTTATTAATATTTTGGCGTTCTTTTTGGAGAGGAACTTTTGGGATGTAGCCT TTACCTGTTTCCTGAATTTGACATCCAAAAAGCCTTTTGGAAAACACCATTCTAAATTTATCCTGTTCTGAATCATCATCGCTTCTGATAGATGCAGTTG CTTGCTGACATCGTGATCTTTGATTTTGTACAACGCTATTTGGGCTAACTTTTGGGATTTTACTTTGTGCTTAGAATTTGAAAGTAGTATTCATTGGAAA GAGACTCCAAGAAAATACTCGAAGACATCAAAAGCTGGATTCGAGGGTATAACGTGTTTTGTTTTGTTTTTTAAATTAGAAAAATAAGGAATTGCAGTGT GATTTTCTTTCCCCCTTTAACTTAGAGGAACGAGGATTATACAGAAATTTGAAATTTCAACAAGAAAAACTTAAGCTTCCTTGGATTCCCACGTCAAAGG AAAGTTTCAAGCTTTCAGAAGGAGTTCTCACTCGAAGATAAAGAACAGCTCGCTAACCACGAAAGAGGAATCGATGCTCAGCTTTTAGTTGCACTTCCTA AAGTTGCAGAATTAAGACAAATCTTTGAACCAAAGAAGAAAGAATTCTTAGAAATGAAAAGAAAAGAAAGAATTGCCAGGCGCCTGGAAGGGATTGAAAA TGACACTCAGCCCATCCTCTTGCAGAGCTGCACAGGATTGGTGACTCACCGCCTGCTGGAGGAAGACACCCCTCGATACATGAGAGCCAGCGACCCTGCC AGCCCCCACATCGGCCGATCAAATGAAGAGGAGGAAACTTCTGATTCTTCTCTAGAAAAGCAAACTCGATCCAAATACTGCACAGAAACCTCCGGTGTCC ACGGTGACTCACCCTATGGTTCGGGTACCATGGACACCCACAGTCTGGAGTCCAAAGCCGAAAGAATTGCAAGGTACAAAGCAGAAAGAAGGCGACAGCT GGCAGAGAAGTATGGGCTGACTCTGGATCCCGAGGCCGACTCCGAGTATTTATCCCGCTATACCAAGTCCAGGAAGGAGCCTGATGCTGTCGAGAAGCGG GGAGGAAAAAGTGACAAACAGGAAGAGTCAAGCAGAGATGCTAGTTCTCTGTACCCCGGGACCGAGACGATGGGGCTCAGGACCTGTGCCGGTGAATCCA AGGACTATGCCCTCCATGTGGGTGACGGCTCTTCCGACCCGGAGGTGCTGCTGAACATAGAAAACCAAAGACGAGGTCAAGAGCTGAGTGCCACCCGGCA GGCCCATGACCTGTCCCCAGCAGCCGAGAGTTCCTCGACCTTCTCTTTCTCTGGGCGAGACTCCTCCTTCACTGAAGTGCCACGGTCCCCCAAGCACGCC CACAGCTCCTCCCTGCAGCAGGCAGCCTCCCGGAGCCCCTCCTTTGGTGACCCACAGCTATCCCCTGAGGCCCGACCCAGTACAGGGAAACCCAAACATG AGTGGTTTCTCCAGAAAGATTCCGAAGGGGACACACCTTCACTTATCAACTGGCCTTCCAGAGTTAAAGTTAGAGAAAAATTGGTGAAAGAGGAAAGTGC TCGAAACAGCCCTGAACTCGCCTCAGAGTCCGTAACTCAGAGGAGACACCAGCCAGCGCCAGTCCATTACGTGTCATTTCAGTCTGAGCACTCAGCCTTT GATAGGGTCCCCAGCAAGGCAGCAGGCTCTACACGACAGCCAATCCGTGGCTATGTCCAACCCGCAGATACCGGTCACACCGCCAAGCTAGTGACGCCAG AAACCCCAGAAAATGCATCTGAGTGTAGCTGGGTAGCATCAGCCACCCAGAATGTCCCCAAACCTCCCAGCTTGACGGTTCTAGAAGGTGACGGAAGGGA TAGCCCAGTTCTCCATGTCTGCGAGTCAAAAGCAGAAGAAGAAGAAGGGGAAGGAGAAGGAGAAGAAAAAGAAGAAGATGTGTGCTTCACTGAAGCTCTC GAGCAAAGCAAGAAAACCCTACTGGCTTTGGAGGGTGATGGGCTAGTGAGAAGCCCAGAAGATCCCTCTAGAAATGAGGACTTTGGTAAGCCTGCTGTGA GCACAGTCACCTTAGAGCATCAGAAGGAACTGGAAAACGTGGCACAACCCCCTCAAGCTCCGCACCAGCCCACTGAGAGGACAGGCAGGAGCGAGATGGT TCTCTACATTCAAAGTGAGCCTGTGTCCCAAGACGCCAAACCAACTGGTCACAACAGGGAAGCCTCGAAAAAGCGCAAGGTCCGTACCCGCTCTCTGTCA GATTTCACAGGCCCCCCTCAGCTCCAGGCCTTGAAGTATAAGGACCCAGCTTCCAGGAGAGAGCTGGAGCTGCCCAGCTCCAAGACCGAAGGGCCTTATG GGGAGATCAGCATGCTGGACACAAAAGTCTCTGTCGCCCAGCTCCGAAGTGCGTTCCTGGCATCTGCCAACGCCTGCAGGAGACCTGAACTCAAATCACG GGTGGAGAGGTCGGCTGAAGGACCTGGCTTGCCCACCGGTGTGGAACGGGAGAGAGGGTCCCGGAAACCAAGACGCTATTTTTCTCCTGGTGAAAGTAGA AAAACTTCCGAGAGATTTAGAACCCAACCTATAACTTCAGCAGAACGAAAGGAATCGGATAGGTGCACTTCACATTCAGAAACGCCAACTGTCGATGATG AAGAAAAGGTGGATGAACGAGCCAAGCTGAGCGTCGCCGCCAAGAGGTTGCTTTTCAGGGAGATGGAAAAATCTTTTGATGAACAAAATGTTCCAAAGCG ACGCTCAAGAAACACAGCTGTGGAGCAGAGGCTACGCCGTCTGCAGGACAGGTCCCTCACCCAGCCCATCACCACTGAAGAGGTGGTCATCGCAGCCACT GAACCTATCCCCGCTTCGTGTTCTGGGGGCACCCACCCTGTAATGGCGAGACTTCCTAGCCCCACTGTAGCTAGGAGCGCTGTGCAGCCTGCCAGATTGC AGGCCTCTGCTCACCAAAAGGCCTTAGCCAAGGACCAGACAAATGAGGGCAAAGAGCTTGCTGAGCAAGGAGAACCTGATTCCTCCACTCTAAGCTTGGC CGAAAAGTTGGCCTTGTTTAACAAATTGTCCCAGCCAGTCTCAAAAGCGATTTCTACCCGGAACAGAATAGACACGAGACAGAGGAGAATGAACGCTCGC TATCAAACTCAGCCAGTCACACTGGGAGAGGTGGAGCAGGTGCAGAGTGGAAAGCTCATTCCTTTCTCACCTGCCGTGAACACATCAGTGTCTACCGTAG CATCCACGGTTGCTCCAATGTATGCCGGAGATCTTCGCACAAAGCCACCTCTTGACCACAATGCAAGTGCCACTGACTATAAGTTTTCTTCTTCAATAGA AAATTCGGACTCTCCAGTTAGAAGCATTCTGAAATCGCAAGCTTGGCAGCCTTTGGTAGAGGGTAGCGAGAACAAGGGAATGTTGAGAGAATATGGAGAG ACAGAAAGCAAGAGAGCTTTGACAGGTCGAGACAGTGGGATGGAGAAGTATGGGTCCTTTGAGGAAGCAGAAGCATCCTACCCCATCCTGAACCGAGCCA GGGAAGGAGACAGCCATAAGGAATCTAAATATGCTGTTCCCAGAAGAGGAAGCCTGGAACGGGCGAACCCTCCCATCACCCACCTCGGGGATGAACCGAA GGAATTTTCCATGGCTAAAATGAATGCACAAGGAAACTTGGACTTGAGGGACAGGCTGCCCTTTGAAGAGAAGGTGGAGGTGGAGAATGTTATGAAAAGG AAGTTTTCACTAAGAGCGGCAGAGTTCGGGGAGCCCACTTCCGAGCAGACGGGGACAGCTGCTGGGAAAACTATTGCTCAAACCACAGCCCCCGTGTCCT GGAAGCCCCAGGATTCTTCGGAACAGCCACAGGAGAAGCTCTGCAAGAATCCATGTGCGATGTTTGCTGCTGGAGAGATCAAAACGCCGACAGGGGAGGG CCTTCTTGACTCACCCAGCAAAACCATGTCTATTAAAGAAAGATTGGCACTGTTGAAGAAAAGCGGGGAGGAAGATTGGAGAAACAGACTCAGCAGGAGG CAGGAGGGCGGCAAGGCGCCGGCCAGCAGCCTGCACACCCAGGAAGCAGGGCGGTCCCTCATCAAGAAGCGGGTCACAGAAAGTCGAGAGAGCCAAATGA CGATTGAGGAGAGGAAGCAGCTCATCACTGTGAGAGAGGAGGCCTGGAAGACGAGAGGCAGAGGAGCGGCCAACGACTCGACCCAGTTCACTGTGGCTGG CAGGATGGTGAAGAAAGGTTTGGCGTCACCTACTGCCATAACCCCAGTAGCCTCACCCATTTGCGGTAAAACAAGAGGCACCACACCCGTTTCCAAACCC CTGGAAGATATCGAAGCCAGACCAGATATGCAGTTAGAATCGGACCTGAAGTTGGACAGGCTGGAAACCTTTCTAAGAAGGCTGAATAACAAAGTTGGCG GGATGCACGAAACGGTGCTCACTGTCACCGGCAAATCTGTGAAGGAGGTGATGAAGCCAGATGATGATGAAACCTTTGCCAAATTTTACCGCAGCGTGGA TTATAATATGCCAAGAAGTCCTGTGGAGATGGATGAGGACTTCGATGTCATTTTCGATCCTTATGCACCCAAATTGACGTCTTCCGTGGCCGAGCACAAG CGGGCAGTTAGGCCCAAGCGCCGGGTTCAGGCCTCCAAAAACCCCCTGAAAATGCTGGCGGCAAGAGAAGATCTCCTTCAGGAATACACTGAGCAGAGAT TAAACGTTGCCTTCATGGAGTCAAAGCGGATGAAAGTAGAAAAGATGTCTTCCAACTCCAACTTCTCAGAAGTCACCCTGGCGGGTTTAGCCAGTAAAGA AAACTTCAGCAACGTCAGCCTGCGGAGCGTCAACCTGACGGAACAGAACTCTAACAACAGCGCCGTGCCCTACAAGAGGCTGATGCTGTTGCAGATTAAA GGAAGAAGACATGTGCAGACCAGGCTGGTGGAACCTCGAGCTTCGGCGCTCAACAGTGGGGACTGCTTCCTCCTGCTCTCTCCCCACTGCTGCTTCCTGT GGGTAGGAGAGTTTGCAAACGTCATAGAAAAGGCGAAGGCCTCAGAACTTGCAACTTTAATTCAGACAAAGAGGGAACTTGGTTGTAGAGCTACTTATAT CCAAACCATTGAAGAAGGAATTAATACACACACTCATGCAGCCAAAGACTTCTGGAAGCTTCTGGGTGGCCAAACCAGTTACCAATCTGCTGGAGACCCA AAAGAAGATGAACTCTATGAAGCAGCCATAATAGAAACTAACTGCATTTACCGTCTCATGGATGACAAACTTGTTCCTGATGACGACTACTGGGGGAAAA TTCCGAAGTGCTCCCTTCTGCAACCCAAAGAGGTACTGGTGTTTGATTTTGGTAGTGAAGTTTACGTATGGCATGGGAAAGAAGTCACATTAGCACAACG AAAAATAGCATTTCAGCTGGCAAAGCACTTATGGAATGGAACCTTTGACTATGAGAACTGTGACATCAATCCCCTGGATCCTGGAGAATGCAATCCGCTT ATCCCCAGAAAAGGACAGGGGCGGCCCGACTGGGCGATATTTGGGAGACTTACTGAACACAATGAGACGATTTTGTTCAAAGAGAAGTTTCTGGATTGGA CGGAACTGAAGAGATCGAATGAGAAGAACCCCGGGGAACTTGCCCAGCACAAGGAAGACCCCAGGACTGATGTCAAGGCATACGATGTGACACGGATGGT GTCCATGCCCCAGACGACAGCAGGCACCATCCTGGACGGAGTGAACGTCGGCCGTGGCTATGGCCTGGTGGAAGGACACGACAGGAGGCAGTTTGAGATC ACCAGCGTTTCCGTGGATGTCTGGCACATCCTGGAATTCGACTATAGCAGGCTCCCCAAACAAAGCATCGGGCAGTTCCATGAGGGGGATGCCTATGTGG TCAAGTGGAAGTTCATGGTGAGCACGGCAGTGGGAAGTCGCCAGAAGGGAGAGCACTCGGTGAGGGCAGCCGGCAAAGAGAAGTGCGTCTACTTCTTCTG GCAAGGCCGGCACTCCACCGTGAGTGAGAAGGGCACGTCGGCGCTGATGACGGTGGAGCTGGACGAGGAAAGGGGGGCCCAGGTCCAGGTTCTCCAGGGA AAGGAGCCCCCCTGTTTCCTGCAGTGTTTCCAGGGGGGGATGGTGGTGCACTCGGGGAGGCGGGAAGAGGAAGAAGAAAATGTGCAAAGTGAGTGGCGGC TGTACTGCGTGCGTGGAGAGGTGCCCGTGGAAGGGAATTTGCTGGAAGTGGCCTGTCACTGTAGCAGCCTGAGGTCCAGAACTTCCATGGTGGTGCTTAA CGTCAACAAGGCCCTCATCTACCTGTGGCACGGATGCAAAGCCCAGGCCCACACGAAGGAGGTCGGAAGGACCGCTGCGAACAAGATCAAGGAACAATGT CCCCTGGAAGCAGGACTGCATAGTAGCAGCAAAGTCACAATACACGAGTGTGATGAAGGCTCCGAGCCACTCGGATTCTGGGATGCCTTAGGAAGGAGAG ACAGGAAAGCCTACGATTGCATGCTTCAAGATCCTGGAAGTTTTAACTTCGCGCCCCGCCTGTTCATCCTCAGCAGCTCCTCTGGGGATTTTGCAGCCAC AGAGTTTGTGTACCCTGCCCGAGCCCCCTCTGTGGTCAGTTCCATGCCCTTCCTGCAGGAAGATCTGTACAGCGCGCCCCAGCCAGCACTTTTCCTTGTT GACAATCACCACGAGGTGTACCTCTGGCAAGGCTGGTGGCCCATCGAGAACAAGATCACTGGTTCCGCCCGCATCCGCTGGGCCTCCGACCGGAAGAGTG CGATGGAGACTGTGCTCCAGTACTGCAAAGGAAAAAATCTCAAGAAACCAGCCCCCAAGTCTTACCTTATCCACGCTGGTCTGGAGCCCCTGACATTCAC CAATATGTTTCCCAGCTGGGAGCACAGAGAGGACATCGCTGAGATCACAGAGATGGACACGGAAGTTTCCAATCAGATCACCCTCGTGGAAGACGTCTTA GCCAAGCTCTGTAAAACCATTTACCCGCTGGCCGACCTCCTGGCCAGGCCACTCCCGGAGGGGGTCGATCCTCTGAAGCTTGAGATCTATCTCACCGACG AAGACTTCGAGTTTGCACTAGACATGACGAGGGATGAATACAACGCCCTGCCCGCCTGGAAGCAGGTGAACCTGAAGAAAGCAAAAGGCCTGTTCTGAGT GGGGAGACGCCAGAGGAGCCTCACGGTCACGTCCAACAACACCACTGCACCAGGGAAATGGATATATATTTTTGGACTGGTGTTTTTCACAAAGTATTTT TCAATCAGAGTTTTCAGAACCTGACATTGTTAAAGATACTGCTTGTCCCGGAGTTGTGTATTTTGTAAATGTTCAAGGGAACTGTTTGGAAACTTCTTTC CACCATTCAGGAGGTTATCAGAATTAATAAAAGTATCTGTTATGTGCACTTAAGCCGCAGCTGCTATAGATAGCACTGCCTTCTTGTTCCAGCTAGGCAA TGCCTTTTTTTTTTTTTTTTGAAGCAGTTCTCTTTATAAAGTGTTATTTTGATAGTTTGTGGATTCTAAAATATATATATATTTATATAAACACCATATA AGTCAAATATGTATTTAACAAAGCAATATGTATTCATTCACTTTCAAGATTTGTTTTGGTGTCAAAATAACATGAAAAGGTAGATGGAGTTGCTTCTGTT GAATTAGCTCTGCCACCAATATGTATCTTCATACACGTTTGGAAATGTTTCCTGCAGCATTAGGTATGACTTGTTCTGAGTACTGCTTCCGGTGCTAAAA TGAACAAAGAATTTGTACTTAATGGCATGGACTCTGGAGAATCTATGCGAATCAACCTTTCTACCTTAATATCTCCCCAAAAATGTATAGTGCCTTGTTT TTATGTACAGTTTATATACAGAAAAGTTTGCTCTGCATTTTTGATGATGGTTTGGAACATTATCTACAATTTTACTCTCAAATAGTCAAAATAAAAACAT CTCAATTTCTAATACCGGTTGTAAACAGTACACATGTCATTTTGTGATATAGGACTCCCAAATAAAAGTATCAGAATAAACACAACAATTAACTGGT

refseq_SVIL.F1 (forward primer)
refseq_SVIL.R1 (reverse primer)
Single exon skipping

Frame 0

HCSDCVLPRLKCPQVSCGFAQ*WMAPPRPGWGS SASRTLGDEKLQKEDSFY*YFGVLFGEELLGCSL YLFPEFDIQKAFWKTPF*IYPVLNHHRF**MQL LADIVIFDFVQRYLG*LLGFYFVLRI*K*YSLE RDSKKILEDIKSWIRGYNVFCFVF*IRKIRNCSV IFFPPLT*RNEDYTEI*NFNKKNLSFLGFPRQR KVSSFQKEFSLEDKEQLANHERGIDAQLLVALP KVAELRQIFEPKKKEFLEMKRKERIARRLEGIEN DTQPILLQSCTGLVTHRLLEEDTPRYMRASDPA SPHIGRSNEEEETSDSSLEKQTRSKYCTETSGV HGDSPYGSGTMDTHSLESKAERIARYKAERRRQL AEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKR GGKSDKQEESSRDASSLYPGTETMGLRTCAGES KDYALHVGDGSSDPEVLLNIENQRRGQELSATRQ AHDLSPAAESSSTFSFSGRDSSFTEVPRSPKHA HSSSLQQAASRSPSFGDPQLSPEARPSTGKPKH EWFLQKDSEGDTPSLINWPSRVKVREKLVKEESA RNSPELASESVTQRRHQPAPVHYVSFQSEHSAF DRVPSKAAGSTRQPIRGYVQPADTGHTAKLVTP ETPENASECSWVASATQNVPKPPSLTVLEGDGRD SPVLHVCESKAEEEEGEGEGEEKEEDVCFTEAL EQSKKTLLALEGDGLVRSPEDPSRNEDFGKPAV STVTLEHQKELENVAQPPQAPHQPTERTGRSEMV LYIQSEPVSQDAKPTGHNREASKKRKVRTRSLS DFTGPPQLQALKYKDPASRRELELPSSKTEGPY GEISMLDTKVSVAQLRSAFLASANACRRPELKSR VERSAEGPGLPTGVERERGSRKPRRYFSPGESR KTSERFRTQPITSAERKESDRCTSHSETPTVDD EEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKR RSRNTAVEQRLRRLQDRSLTQPITTEEVVIAAT EPIPASCSGGTHPVMARLPSPTVARSAVQPARL QASAHQKALAKDQTNEGKELAEQGEPDSSTLSLA EKLALFNKLSQPVSKAISTRNRIDTRQRRMNAR YQTQPVTLGEVEQVQSGKLIPFSPAVNTSVSTV ASTVAPMYAGDLRTKPPLDHNASATDYKFSSSIE NSDSPVRSILKSQAWQPLVEGSENKGMLREYGE TESKRALTGRDSGMEKYGSFEEAEASYPILNRA REGDSHKESKYAVPRRGSLERANPPITHLGDEPK EFSMAKMNAQGNLDLRDRLPFEEKVEVENVMKR KFSLRAAEFGEPTSEQTGTAAGKTIAQTTAPVS WKPQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEG LLDSPSKTMSIKERLALLKKSGEEDWRNRLSRR QEGGKAPASSLHTQEAGRSLIKKRVTESRESQM TIEERKQLITVREEAWKTRGRGAANDSTQFTVAG RMVKKGLASPTAITPVASPICGKTRGTTPVSKP LEDIEARPDMQLESDLKLDRLETFLRRLNNKVG GMHETVLTVTGKSVKEVMKPDDDETFAKFYRSVD YNMPRSPVEMDEDFDVIFDPYAPKLTSSVAEHK RAVRPKRRVQASKNPLKMLAAREDLLQEYTEQR LNVAFMESKRMKVEKMSSNSNFSEVTLAGLASKE NFSNVSLRSVNLTEQNSNNSAVPYKRLMLLQIK GRRHVQTRLVEPRASALNSGDCFLLLSPHCCFL WVGEFANVIEKAKASELATLIQTKRELGCRATYI QTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDP KEDELYEAAIIETNCIYRLMDDKLVPDDDYWGK IPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQR KIAFQLAKHLWNGTFDYENCDINPLDPGECNPL IPRKGQGRPDWAIFGRLTEHNETILFKEKFLDW TELKRSNEKNPGELAQHKEDPRTDVKAYDVTRMV SMPQTTAGTILDGVNVGRGYGLVEGHDRRQFEI TSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYV VKWKFMVSTAVGSRQKGEHSVRAAGKEKCVYFFW QGRHSTVSEKGTSALMTVELDEERGAQVQVLQG KEPPCFLQCFQGGMVVHSGRREEEEENVQSEWR LYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLN VNKALIYLWHGCKAQAHTKEVGRTAANKIKEQC PLEAGLHSSSKVTIHECDEGSEPLGFWDALGRR DRKAYDCMLQDPGSFNFAPRLFILSSSSGDFAAT EFVYPARAPSVVSSMPFLQEDLYSAPQPALFLV DNHHEVYLWQGWWPIENKITGSARIRWASDRKS AMETVLQYCKGKNLKKPAPKSYLIHAGLEPLTFT NMFPSWEHREDIAEITEMDTEVSNQITLVEDVL AKLCKTIYPLADLLARPLPEGVDPLKLEIYLTD EDFEFALDMTRDEYNALPAWKQVNLKKAKGLF*V GRRQRSLTVTSNNTTAPGKWIYIFGLVFFTKYF SIRVFRT*HC*RYCLSRSCVFCKCSRELFGNFF PPFRRLSELIKVSVMCT*AAAAIDSTAFLFQLGN AFFFFF*SSSLYKVLF**FVDSKIYIYLYKHHI SQICI*QSNMYSFTFKICFGVKIT*KGRWSCFC *ISSATNMYLHTRLEMFPAALGMTCSEYCFRC*N EQRICT*WHGLWRIYANQPFYLNISPKMYSALF LCTVYIQKSLLCIFDDGLEHYLQFYSQIVKIKT SQFLIPVVNSTHVIL*YRTPK*KYQNKHNN*L

Frame 1

TALTASSPG*SVLRFHVDLPSNGWLHRGQVGEV QPRGH*GTKNFKKKTLFINILAFFLERNFWDVA FTCFLNLTSKKPFGKHHSKFILF*IIIASDRCSC LLTS*SLILYNAIWANFWDFTLCLEFESSIHWK ETPRKYSKTSKAGFEGITCFVLFFKLEK*GIAV *FSFPL*LRGTRIIQKFEISTRKT*ASLDSHVKG KFQAFRRSSHSKIKNSSLTTKEESMLSF*LHFL KLQN*DKSLNQRRKNS*K*KEKKELPGAWKGLK MTLSPSSCRAAQDW*LTACWRKTPLDT*EPATLP APTSADQMKRRKLLILL*KSKLDPNTAQKPPVS TVTHPMVRVPWTPTVWSPKPKELQGTKQKEGDS WQRSMG*LWIPRPTPSIYPAIPSPGRSLMLSRSG EEKVTNRKSQAEMLVLCTPGPRRWGSGPVPVNP RTMPSMWVTALPTRRCC*T*KTKDEVKS*VPPG RPMTCPQQPRVPRPSLSLGETPPSLKCHGPPSTP TAPPCSRQPPGAPPLVTHSYPLRPDPVQGNPNM SGFSRKIPKGTHLHLSTGLPELKLEKNW*KRKV LETALNSPQSP*LRGDTSQRQSITCHFSLSTQPL IGSPARQQALHDSQSVAMSNPQIPVTPPS**RQ KPQKMHLSVAG*HQPPRMSPNLPA*RF*KVTEG IAQFSMSASQKQKKKKGKEKEKKKKKMCASLKLS SKARKPYWLWRVMG**EAQKIPLEMRTLVSLL* AQSP*SIRRNWKTWHNPLKLRTSPLRGQAGARW FSTFKVSLCPKTPNQLVTTGKPRKSARSVPALCQ ISQAPLSSRP*SIRTQLPGESWSCPAPRPKGLM GRSACWTQKSLSPSSEVRSWHLPTPAGDLNSNH GWRGRLKDLACPPVWNGREGPGNQDAIFLLVKVE KLPRDLEPNL*LQQNERNRIGALHIQKRQLSMM KKRWMNEPS*ASPPRGCFSGRWKNLLMNKMFQS DAQETQLWSRGYAVCRTGPSPSPSPLKRWSSQPL NLSPLRVLGAPTL*WRDFLAPL*LGALCSLPDC RPLLTKRP*PRTRQMRAKSLLSKENLIPPL*AW PKSWPCLTNCPSQSQKRFLPGTE*TRDRGE*TLA IKLSQSHWERWSRCRVESSFLSHLP*THQCLP* HPRLLQCMPEIFAQSHLLTTMQVPLTISFLLQ* KIRTLQLEAF*NRKLGSLW*RVARTREC*ENMER QKAREL*QVETVGWRSMGPLRKQKHPTPS*TEP GKETAIRNLNMLFPEEEAWNGRTLPSPTSGMNR RNFPWLK*MHKETWT*GTGCPLKRRWRWRML*KG SFH*ERQSSGSPLPSRRGQLLGKLLLKPQPPCP GSPRILRNSHRRSSARIHVRCLLLERSKRRQGR AFLTHPAKPCLLKKDWHC*RKAGRKIGETDSAGG RRAARRRPAACTPRKQGGPSSRSGSQKVERAK* RLRRGSSSSL*ERRPGRREAEERPTTRPSSLWL AGW*RKVWRHLLP*PQ*PHPFAVKQEAPHPFPNP WKISKPDQICS*NRT*SWTGWKPF*EG*ITKLA GCTKRCSLSPANL*RR**SQMMMKPLPNFTAAW IIICQEVLWRWMRTSMSFSILMHPN*RLPWPSTS GQLGPSAGFRPPKTP*KCWRQEKISFRNTLSRD *TLPSWSQSG*K*KRCLPTPTSQKSPWRV*PVK KTSATSACGAST*RNRTLTTAPCPTRG*CCCRLK EEDMCRPGWWNLELRRSTVGTASSCSLPTAASC G*ESLQTS*KRRRPQNLQL*FRQRGNLVVELLI SKPLKKELIHTLMQPKTSGSFWVAKPVTNLLETQ KKMNSMKQP**KLTAFTVSWMTNLFLMTTTGGK FRSAPFCNPKRYWCLILVVKFTYGMGKKSH*HN EK*HFSWQSTYGMEPLTMRTVTSIPWILENAIRL SPEKDRGGPTGRYLGDLLNTMRRFCSKRSFWIG RN*RDRMRRTPGNLPSTRKTPGLMSRHTM*HGW CPCPRRQQAPSWTE*TSAVAMAWWKDTTGGSLRS PAFPWMSGTSWNSTIAGSPNKASGSSMRGMPMW SSGSSW*ARQWEVARRESTR*GQPAKRSASTSS GKAGTPP*VRRARRR**RWSWTRKGGPRSRFSRE RSPPVSCSVSRGGWWCTRGGGKRKKKMCKVSGG CTACVERCPWKGICWKWPVTVAA*GPELPWWCL TSTRPSSTCGTDAKPRPTRRRSEGPLRTRSRNNV PWKQDCIVAAKSQYTSVMKAPSHSDSGMP*EGE TGKPTIACFKILEVLTSRPACSSSAAPLGILQP QSLCTLPEPPLWSVPCPSCRKICTARPSQHFSLL TITTRCTSGKAGGPSRTRSLVPPASAGPPTGRV RWRLCSSTAKEKISRNQPPSLTLSTLVWSP*HS PICFPAGSTERTSLRSQRWTRKFPIRSPSWKTS* PSSVKPFTRWPTSWPGHSRRGSIL*SLRSISPT KTSSLH*T*RGMNTTPCPPGSR*T*RKQKACSE WGDARGASRSRPTTPLHQGNGYIFLDWCFSQSIF QSEFSEPDIVKDTACPGVVYFVNVQGNCLETSF HHSGGYQN**KYLLCALKPQLL*IALPSCSS*A MPFFFFFEAVLFIKCYFDSLWILKYIYIYINTI* VKYVFNKAICIHSLSRFVLVSK*HEKVDGVASV ELALPPICIFIHVWKCFLQH*V*LVLSTASGAK MNKEFVLNGMDSGESMRINLSTLISPQKCIVPCF YVQFIYRKVCSAFLMMVWNIIYNFTLK*SK*KH LNF*YRL*TVHMSFCDIGLPNKSIRINTTINW

Frame 2

LL*LRPPQAEVSSGFMWICPVMDGSTEARLGKF SLEDTRGRKTSKRRLFLLIFWRSFWRGTFGM*P LPVS*I*HPKSLLENTILNLSCSESSSLLIDAV AC*HRDL*FCTTLFGLTFGILLCA*NLKVVFIGK RLQENTRRHQKLDSRV*RVLFCFLN*KNKELQC DFLSPFNLEERGLYRNLKFQQEKLKLPWIPTSK ESFKLSEGVLTRR*RTAR*PRKRNRCSAFSCTS* SCRIKTNL*TKEERILRNEKKRKNCQAPGRD*K *HSAHPLAELHRIGDSPPAGGRHPSIHESQRPC QPPHRPIK*RGGNF*FFSRKANSIQILHRNLRCP R*LTLWFGYHGHPQSGVQSRKNCKVQSRKKATA GREVWADSGSRGRLRVFIPLYQVQEGA*CCREA GRKK*QTGRVKQRC*FSVPRDRDDGAQDLCR*IQ GLCPPCG*RLFRPGGAAEHRKPKTRSRAECHPA GP*PVPSSREFLDLLFLWARLLLH*SATVPQAR PQLLPAAGSLPEPLLW*PTAIP*GPTQYRETQT* VVSPERFRRGHTFTYQLAFQS*S*RKIGERGKC SKQP*TRLRVRNSEETPASASPLRVISV*ALSL **GPQQGSRLYTTANPWLCPTRRYRSHRQASDAR NPRKCI*V*LGSISHPECPQTSQLDGSRR*RKG *PSSPCLRVKSRRRRRGRRRRRKRRRCVLH*SS RAKQENPTGFGG*WASEKPRRSL*K*GLW*ACCE HSHLRASEGTGKRGTTPSSSAPAH*EDRQERDG SLHSK*ACVPRRQTNWSQQGSLEKAQGPYPLSV RFHRPPSAPGLEV*GPSFQERAGAAQLQDRRALW GDQHAGHKSLCRPAPKCVPGICQRLQET*TQIT GGEVG*RTWLAHRCGTGERVPETKTLFFSW*K* KNFREI*NPTYNFSRTKGIG*VHFTFRNANCR** RKGG*TSQAERRRQEVAFQGDGKIF**TKCSKA TLKKHSCGAEATPSAGQVPHPAHHH*RGGHRSH *TYPRFVFWGHPPCNGETS*PHCS*ERCAACQIA GLCSPKGLSQGPDK*GQRAC*ARRT*FLHSKLG RKVGLV*QIVPASLKSDFYPEQNRHETEENERS LSNSASHTGRGGAGAEWKAHSFLTCREHISVYRS IHGCSNVCRRSSHKATS*PQCKCH*L*VFFFNR KFGLSS*KHSEIASLAAFGRG*REQGNVERIWR DRKQESFDRSRQWDGEVWVL*GSRSILPHPEPSQ GRRQP*GI*ICCSQKRKPGTGEPSHHPPRG*TE GIFHG*NECTRKLGLEGQAAL*REGGGGECYEK EVFTKSGRVRGAHFRADGDSCWENYCSNHSPRVL EAPGFFGTATGEALQESMCDVCCWRDQNADRGG PS*LTQQNHVY*RKIGTVEEKRGGRLEKQTQQE AGGRQGAGQQPAHPGSRAVPHQEAGHRKSREPND D*GEEAAHHCERGGLEDERQRSGQRLDPVHCGW QDGEERFGVTYCHNPSSLTHLR*NKRHHTRFQT PGRYRSQTRYAVRIGPEVGQAGNLSKKAE*QSWR DARNGAHCHRQICEGGDEAR***NLCQILPQRG L*YAKKSCGDG*GLRCHFRSLCTQIDVFRGRAQ AGS*AQAPGSGLQKPPENAGGKRRSPSGIH*AEI KRCLHGVKADESRKDVFQLQLLRSHPGGFSQ*R KLQQRQPAERQPDGTEL*QQRRALQEADAVAD* RKKTCADQAGGTSSFGAQQWGLLPPALSPLLLPV GRRVCKRHRKGEGLRTCNFNSDKEGTWL*SYLY PNH*RRN*YTHSCSQRLLEASGWPNQLPICWRP KRR*TL*SSHNRN*LHLPSHG*QTCS**RLLGEN SEVLPSATQRGTGV*FW**SLRMAWERSHISTT KNSISAGKALMEWNL*L*EL*HQSPGSWRMQSA YPQKRTGAARLGDIWETY*TQ*DDFVQREVSGLD GTEEIE*EEPRGTCPAQGRPQD*CQGIRCDTDG VHAPDDSRHHPGRSERRPWLWPGGRTRQEAV*D HQRFRGCLAHPGIRL*QAPQTKHRAVP*GGCLCG QVEVHGEHGSGKSPEGRALGEGSRQREVRLLLL ARPALHRE*EGHVGADDGGAGRGKGGPGPGSPG KGAPLFPAVFPGGDGGALGEAGRGRRKCAK*VAA VLRAWRGARGREFAGSGLSL*QPEVQNFHGGA* RQQGPHLPVARMQSPGPHEGGRKDRCEQDQGTM SPGSRTA**QQSHNTRV**RLRATRILGCLRKER QESLRLHASRSWKF*LRAPPVHPQQLLWGFCSH RVCVPCPSPLCGQFHALPAGRSVQRAPASTFPC *QSPRGVPLARLVAHREQDHWFRPHPLGLRPEEC DGDCAPVLQRKKSQETSPQVLPYPRWSGAPDIH QYVSQLGAQRGHR*DHRDGHGSFQSDHPRGRRL SQAL*NHLPAGRPPGQATPGGGRSSEA*DLSHRR RLRVCTRHDEG*IQRPARLEAGEPEESKRPVLS GETPEEPHGHVQQHHCTREMDIYFWTGVFHKVF FNQSFQNLTLLKILLVPELCIL*MFKGTVWKLLS TIQEVIRINKSICYVHLSRSCYR*HCLLVPARQ CLFFFFLKQFSL*SVILIVCGF*NIYIFI*TPY KSNMYLTKQYVFIHFQDLFWCQNNMKR*MELLLL N*LCHQYVSSYTFGNVSCSIRYDLF*VLLPVLK *TKNLYLMAWTLENLCESTFLP*YLPKNV*CLV FMYSLYTEKFALHF**WFGTLSTILLSNSQNKNI SISNTGCKQYTCHFVI*DSQIKVSE*TQQLTG