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Sequence NM_001002881
CAACCATGTAAGCAGCTTCGCTTCCTGCCGCAACCGTCCGCGGCCTGAGGAGCCCACCGCCGCTCTCGGGGGCCGACTTCCGGGGGCTGAGCCGTTGAAGCGGAGGCTGGGGCGGGGGGCAGCCGGCGCGGCCGGGGCAGGAGGCGCAGACTCATGAAATGGCCACAGATGATAAGACGTCCCCAACACTGGACTCTGCT
AATGATTTGCCTCGATCTCCTACTAGTCCTTCTCATCTCACACACTTTAAACCTTTGACTCCTGATCAAGATGAGCCCCCTTTTAAATCAGCTTATAGTT
CTTTTGTAAATCTCTTTCGTTTTAACAAAGAGAGAGCAGAAGGAGGCCAGGGAGAACAGCAGCCTTTGAGTGGAAGTTGGACCAGCCCTCAGCTCCCTTC
GAGGACACAGTCTGTTAGGTCACCCACACCTTATAAAAAGCAGCTTAATGAGGAACTCCAGCGGCGCTCTTCAGCATTAGACACAAGAAGGAAAGCAGAA
CCTACCTTTGGAGGTCATGACCCTCGTACAGCTGTTCAGCTTCGAAGCCTCAGCACAGTATTAAAACGCCTCAAGGAAATCATGGAGGGGAAAAGCCAGG
AGACCTCCGAGCTTGCACATATTGTAGAAAAATAGCCTTAAGTTATGCTCATTCCACAGACAGTAATTCTATTGGGGAAGACTTGAATGCTCTTTCAGAT
TCTGCTTGCTCTGTGTCTGTGCTTGATCCAAGTGAACCCCGAACACCTGTTGGGAGTAGGAAAGCCAGCCGTAACATATTTTTAGAGGATGATTTGGCCT
GGCAAAGTTTGATTCATCCAGATTCCTCAAATACTCCTCTTTCAACAAGACTTGTATCTGTGCAAGAGGATGCTGGGAAATCTCCTGCTCGAAATAGATC
AGCCAGCATTACTAACCTGTCACTGGATAGATCTGGTTCTCCTATGGTACCTTCATATGAGACATCTGTCAGTCCCCAGGCTAACCGAACATATGTTAGG
ACAGAGACCACTGAGGATGAACGCAAAATTCTTCTGGACAGTGTGCAGTTAAAAGACCTGTGGAAAAAAATCTGCCATCACAGCAGTGGAATGGAGTTTC
AGGATCACCGCTACTGGTTGAGAACGCATCCCAACTGCATTGTAGGAAAGGAATTAGTCAACTGGCTAATCCGAAATGGGCATATTGCCACAAGGGCACA
AGCTATAGCAATTGGACAAGCAATGGTTGATGGACGTTGGCTGGATTGTGTTAGTCATCACGACCAGCTTTTCAGAGATGAGTATGCGCTGTATAGACCA
CTGCAGAGTACAGAATTTTCTGAGACGCCTTCTCCCGACAGTGACTCAGTGAACTCCGTGGAAGGACACTCTGAGCCATCCTGGTTTAAAGACATAAAGT
TTGATGACAGTGACACAGAACAGATAGCTGAAGAAGGTGACGATAATTTGGCTAATTCTGCCAGTCCTAGCAAGCGCACATCAGTCAGCAGTTTCCAGTC
CACAGTGGACAGTGACTCAGCCGCTTCTATCAGCCTGAACGTGGAGCTGGACAACGTGAACTTCCATATCAAGAAGCCCTCCAAGTACCCACATGTGCCC
CCTCACCCTGCTGACCAAAAAGAGTATTTGATTTCTGACACTGGAGGACAACAGCTCTCAATAAGTGACGCTTTCATCAAAGAATCCTTATTTAATCGCC
GAGTAGAGGAAAAATCCAAAGAGCTGCCTTTCACACCTTTGGGCTGGCATCATAACAACCTGGAGCTCCTGAGGGAGGAGAATGGGGAGAAACAAGCCAT
GGAGAGGTTGCTTTCAGCTAATCATAACCACATGATGGCACTACTCCAGCAGTTGCTCCATAGTGACTCACTGTCATCATCTTGGAGGGACATCATCGTG
TCATTGGTCTGCCAGGTTGTTCAGACAGTCCGACCTGATGTCAAGAACCAGGATGATGACATGGATATCCGTCAGTTTGTCCACATCAAAAAAATCCCAG
GTGGAAAGAAGTTTGATTCTGTGGTTGTCAATGGCTTTGTTTGTACCAAGAACATTGCACATAAAAAGATGAGTTCTTGTATTAAAAACCCCAAAATTCT
TCTGTTGAAGTGTTCCATTGAGTATCTCTACAGAGAAGAAACTAAGTTTACTTGCATTGATCCTATTGTGCTTCAGGAAAGGGAATTCTTGAAGAATTAT
GTCCAGCGAATAGTTGATGTTCGACCCACCTTGGTTCTTGTTGAGAAAACAGTGTCTCGGATTGCCCAGGACATGTTATTGGAACATGGCATTACTTTGG
TCATTAATGTAAAGTCACAAGTTTTGGAACGAATCAGTCGAATGACCCAAGGTGATTTAGTGATGTCAATGGACCAGCTGCTTACGAAACCACACCTGGG
CACTTGTCACAAATTTTATATGCAGATATTTCAGTTGCCTAATGAACAAACCAAGACACTGATGTTTTTTGAAGGTTGTCCACAGCACCTAGGCTGTACA
ATCAAGCTAAGAGGAGGCTCTGATTATGAGCTGGCTCGAGTTAAGGAGATCCTAATATTTATGATCTGTGTTGCTTATCATTCTCAACTAGAAATATCCT
TTCTCATGGATGAATTTGCTATGCCTCCCACATTAATGCAAAACCCTTCATTCCATTCCCTGATTGAGGGACGAGGGCATGAGGGGGCTGTCCAAGAGCA
GTACGGTGGAGGTTCCATCCCCTGGGATCCTGACATCCCTCCTGAGTCTCTGCCCTGTGATGATAGCAGTTTGCTGGAATTGAGGATTGTGTTTGAGAAG
GGTGAGCAGGAAAATAAAAATCTTCCGCAGGCTGTTGCCTCTGTGAAGCATCAAGAACATAGCACAACAGCTTGCCCGGCGGGTCTCCCTTGTGCTTTCT
TTGCACCTGTACCGGAATCATTGTTGCCACTCCCTGTGGATGACCAACAAGATGCTTTAGGCAGCGAGCAGCCAGAGACTTTGCAGCAAACAGTTGTGCT
GCAGGATCCCAAAAGCCAGATAAGAGCCTTTAGAGACCCTCTACAGGATGACACTGGATTATATGTTACTGAGGAAGTCACCTCCTCTGAAGATAAACGA
AAGACTTATTCTTTGGCCTTTAAGCAGGAATTAAAAGATGTGATCCTCTGTATCTCCCCAGTAATCACATTCCGAGAACCCTTTCTTTTAACTGAAAAGG
GGATGAGATGCTCTACCCGAGATTATTTTGCAGAGCAGGTTTACTGGTCTCCTCTCCTCAATAAAGAATTCAAAGAAATGGAGAACAGGAGGAAGAAACA
GCTGCTCAGGGATCTCTCTGGACTTCAGGGCATGAATGGAAGTATTCAGGCCAAGTCTATTCAAGTCTTACCCTCACATGAGCTAGTGAGCACTAGAATT
GCTGAGCATCTGGGCGATAGCCAGAGCTTGGGTAGAATGCTGGCCGATTATCGAGCCAGAGGAGGAAGAATTCAGCCCAAAAATTCAGACCCTTTTGCTC
ATTCAAAGGATGCATCAAGTACTTCAAGTGGCCAATCAGGAAGCAAAAATGAGGGTGATGAAGAGAGAGGGCTTATTCTGAGTGATGCTGTGTGGTCAAC
AAAGGTGGACTGTCTGAATCCCATTAATCACCAGAGACTTTGTGTGCTCTTCAGCAGCTCTTCTGCCCAGTCCAGCAATGCTCCTAGTGCCTGTGTCAGT
CCTTGGATTGTAACAATGGAATTTTATGGAAAGAATGATCTTACATTAGGAATATTTTTAGAGAGATACTGTTTCAGGCCTTCTTATCAGTGTCCAAGCA
TGTTCTGTGATACCCCCATGGTACATCATATTCGGCGCTTTGTTCATGGCCAAGGCTGTGTGCAGATAATCCTGAAGGAGTTGGATTCTCCAGTACCTGG
ATATCAGCATACAATTCTTACATATTCCTGGTGTAGAATCTGCAAACAGGTAACACCAGTTGTTGCTCTTTCCAATGAGTCCTGGTCTATGTCATTTGCA
AAATACCTTGAACTTAGGTTTTATGGGCACCAGTATACTCGCAGAGCCAACGCTGAGCCCTGTGGTCACTCCATCCATCATGATTATCACCAGTATTTCT
CCTATAACCAGATGGTGGCGTCTTTCAGTTATTCTCCCATTCGGCTTCTTGAAGTATGTGTTCCACTCCCCAAAATATTCATTAAGCGTCAGGCCCCATT
AAAAGTGTCCCTTCTTCAGGATCTGAAGGACTTCTTTCAAAAAGTTTCACAGGTATATGTTGCCATTGATGAAAGACTTGCATCTTTGAAAACTGATACA
TTTAGTAAAACAAGAGAGGAAAAAATGGAAGATATTTTTGCACAGAAAGAGATGGAAGAAGGTGAGTTCAAGAACTGGATTGAGAAGATGCAAGCAAGGC
TCATGTCTTCCTCTGTAGATACCCCTCAGCAACTGCAGTCGGTCTTTGAGTCACTCATTGCCAAGAAACAAAGTCTCTGTGAAGTGCTGCAAGCTTGGAA
TAACAGGTTGCAGGACCTTTTCCAACAGGAAAAGGGTAGAAAGAGACCTTCAGTTCCTCCAAGTCCTGGAAGACTGAGACAAGGGGAAGAAAGCAAGATA
AGTGCGATGGATGCATCTCCACGGAATATTTCTCCAGGACTTCAGAATGGAGAAAAAGAGGATCGCTTCTTAACAACTTTGTCCAGCCAGAGCTCCACCA
GTTCTACTCATCTCCAATTGCCTACGCCACCTGAAGTCATGTCTGAACAGTCAGTGGGAGGGCCCCCTGAGCTAGATACAGCCAGCAGTTCCGAAGATGT
GTTTGATGGGCATTTGCTGGGATCCACAGACAGCCAAGTGAAGGAAAAGTCAACCATGAAAGCCATCTTTGCAAATTTGCTTCCAGGAAATAGCTATAAT
CCTATTCCATTTCCTTTTGATCCAGATAAACACTACTTAATGTATGAACATGAACGAGTGCCCATTGCAGTCTGCGAGAAGGAACCCAGCTCCATCATTG
CTTTTGCTCTCAGTTGTAAAGAATACCGAAATGCCTTAGAGGAATTGTCTAAAGCGACTCAGTGGAACAGTGCCGAAGAAGGGCTTCCAACAAATAGTAC
TTCAGATAGCAGACCAAAGAGTAGCAGCCCTATCAGATTACCTGAAATGAGTGGAGGACAGACAAATCGTACAACAGAAACAGAACCACAACCAACCAAA
AAGGCTTCTGGAATGTTGTCCTTCTTCAGAGGGACAGCAGGGAAAAGCCCCGATCTCTCTTCCCAGAAGAGAGAGACCTTACGTGGAGCAGATAGTGCTT
ACTACCAGGTTGGGCAGACGGGCAAGGAGGGGACCGAGAATCAAGGCGTTGAGCCTCAAGATGAAGTAGATGGAGGAGATACACAAAAGAAGCAACTCAT
AAATCCTCATGTGGAACTTCAATTTTCAGATGCTAATGCCAAGTTTTACTGTCGGCTCTACTATGCGGGAGAGTTTCATAAGATGCGTGAAGTGATTCTG
GACAGCAGTGAAGAAGATTTCATTCGTTCCCTCTCCCACTCATCACCCTGGCAGGCCCGGGGAGGCAAATCAGGAGCTGCCTTCTATGCAACTGAGGATG
ATAGATTTATTTTGAAGCAAATGCCTCGTCTGGAAGTCCAGTCCTTCCTCGACTTTGCACCACATTACTTCAATTATATTACAAATGCTGTTCAACAAAA
GAGGCCCACGGCGTTGGCCAAAATTCTTGGAGTTTACAGAATTGGTTATAAGAACTCTCAGAACAACACTGAGAAGAAGTTAGATCTCCTTGTCATGGAA
AATCTTTTCTACGGGAGAAAGATGGCACAGGTTTTTGATTTGAAGGGCTCTCTTAGGAATCGGAATGTAAAAACTGACACTGGAAAAGAGAGTTGTGATG
TGGTCCTGCTAGATGAAAATCTCCTAAAGATGGTTCGAGACAACCCTCTATATATTCGTTCTCATTCCAAAGCTGTGCTGAGAACCTCGATCCATAGTGA
CTCCCATTTCCTTTCTAGCCACCTCATTATAGATTATTCTTTGCTGGTTGGGCGAGATGATACTAGCAATGAGCTAGTAGTTGGAATTATAGATTATATT
CGAACATTTACATGGGACAAAAAGCTTGAGATGGTTGTGAAATCAACAGGAATTTTAGGTGGACAAGGTAAAATGCCAACAGTGGTGTCTCCGGAGTTGT
ACAGGACTAGGTTTTGTGAGGCAATGGACAAGTATTTCCTAATGGTACCAGACCACTGGACAGGCTTGGGTCTGAATTGCTGAAATCAAGCACATATTTT
GAAATGGACTGTGAAGGAAAAGGGGACAGGAACAAAGGACCAAAAATAAGCTACATGTTTTATTTCTTCATCGTGTTCACCACTGTATGCCAAGGCTTTT
CAGTTCTGTGGCTGTTTAGACTGTCCGTAATGGAATGGTAAAACTCCATGAATTTGCACTTTGGTTTTTGATACCTGTGGAGCTGTCTGTAGGTTGGGAA
GTGGCATGAAAATTTTCTTAAGCTAAAATACAGACATGTTTCAAAGGGCTAAAGTTGGAGATGAGTAGATAGGGTGAAAAATGGGTTAAATTTGCTAGCT
TAATTGTTTTAAGAAGAAAACAGTGTCTCATAAATTGACTATCCTGGCATCACATTTAACATGTTATCTACTTAGAAAGCATTTGTAGAGCTGCTGAATT
TGTTTTGTGTTTTTCTGTAATAATTTAATGTTACTTATTATCAGAATTTCTGAAACCTTTACAAAAATTCTGATTTATTCCATTAATGGCCGGTTAAACA
CGTGGGCATTTATTGTTTTATTGAGGAATTTGACTTAAACTGGGAATCCTGTCATGTTGTTTATCTTTCCAGCTTGCCTGTTTTTGAGTATGTTTGATGT
TTTTAAAATTTTGTCTTCTCTGTGGAAGACAGGAGGCTACAGCAATTAACTTTAAGCCTCCTTTTAGAGATATTTTTAAAACTTGTTTAAAATTTTTGTG
CAATTCATATATTAAATTGCACTTACTTGCATACGCTCATATTCTAGGGTTTTTTCTCTATTTTTAGGGTATCATAGTAAATCATTAGTAAATGAGTCTG
TAGTTACTAAACCCTAATGGAATAATTATTAATGAAAGATTTTTGAAATATAAAAAATAAATTAGGCCCAATCCAAGAAATTGAGTGAGAAGGAAACACT
TGTTTTATTCACAGAGGTAAAGTGTCTTTTCAATATAACCAGCAATTTAGGTGGCATCTATAAAATAAAAAATTTCTACTGTGGACATCCCCTTTTCCAA
CTTTCTACATAATGGCTAGTTCTGACTACTAAGAAATGTTAAGAAATAGGCCAAGTGCGGTGGCTCACGCCTATAATCCTATCACTTTGGGAGGCCTAGG
CAGGCAGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGACGAAACCCCATCTCTACTAAAAAGACAAAAAATTAGCTGGGCATGGTGGC
ATATACCTGTAACCCCAACTACTTGGGTGGCTGAGGCAGGAGAATTGTTTGAACCTGGGAGGCGGAGGCTGCAGTGAGCTGGGATTACACCATTGCATTC
CAGCCTGGGCAACAGAGCAAGACTGTCTCAAAAAACAAAACGAAACAAAAAAAGAAAGTTATTCTTAGTAAGGAACTTCTTGTTTAATAGCATTTTTGTT
TATTTTAAAAAGTGATCAGAAGTAGTAAACTATCTTTGAGGAAATACTGTAACCCCAGAATATTTCCTCTTGACTTCTTTTTGTAACAAGGATAATTTAG
GGATTTATAAAGTTGTAAGGATTTCACTGTTTTTGGACTGCCTATAATAATAGCACATTAACCTTCACATAATAAGAAATCTGGACAAGTTCAGTTACAC
AGTATGATGAATACTTGAATTAGGAACATTGTGGAAAATTTGCTTTAGAGAATCAAGGCAGTAGTTTGGTATTTGGTGCTTATTAAAAATGTGGTTTGTT
TTGAACTGGAAGCAAGTTGACCAAGGACTTATGACTAATGTGATGCTAAGTTCCACTTGGCCCCTTTTAAAAACGTGTATGTGCCTTTTGAAGATACACA
AAACACTGAGGATTTTAGTTTTGAAATCAAAGACTATTAAAGGAGCTGTACAGAGGTAAAAAAATAAATGTGGAACATTATTAACTTACTTTGTGTCTAG
GAACAATGGATTTTGTATCTGATTTAAAATGCCAACACTGTTTTGTCTCTGTTCATTTTTTCTGTGAGGATACTTAAGGTTATTATTCCTGTCTGTTTCC
TGTACTCCCCTAGTCATGAGCACTTGAAGTACAAGGTGTCTCCCCCTAGGTGCAATTAGGTTGTTTCTTTGTTTTTAGTTTCAATTCTATGTGCATAGCA
GGAATGCTCCACAGGAATGGCTTCTGACAATAATCTGTCCTGTTGATTTTGTTTTCCTTGCCCATGACTTGAACAACTGTGTTTTAAAGTACTGTAGTCT
AGTAGGTAACTTTGTGGCAAAAATTTTCAATATAATACATTCTGAAACAATAGTTGCTGCCTTGCAAAGGTAATCTCTCATTTTAAAATTGGACAGTATT
AATGAAGGGGAAATATACAATTTATTTCTATTGAGTGGTAGAACTATATGTCTGGTCCCTTGCTGCTCTTGTTTAGGCCACTATCATAGATATATTTCAA
ATATTGTACTACTCAGTGTTAAGTATTGAATGACTGTTTCCCTTTCCTTCAAGGCCTAGAGTATATTCTGAAAATTTAGGAATGAGGAAGAAATCTTAAT
ACTTCCTTCCTTAACATACAACATGAGTCCCGAGAATAATTGATAGTAGCAAGAGAAAACTATGTCAGTAACATGTTGCTTTGTATAAAAATCTTATTTA
TAAATGTGAAGCTTTTTGATGCCATCAAAACTTATTAAAAAATAGGATTTACTTTTTTCTAATTCTGACCTAAGAAAAATAATGAGAACAAGCTGTTGCA
AGCTCTTTTGTAGTCTATTGAATATTTTATAGATATTCAAAATTTCCTACAAACTATAATTTTTTCCATGATTTAGCAGTGAGTGATTTTCTAGCTTTGG
CTCTTATTAGGTATTGTAAATAGTAGGGTTATATCGATATCAGCTTTTGTGATGGCATTGTGGTCATCAGCTTCATGACATTTTACCCATTTGCAGTGAT
CCTGTGTAAAACTGCCAAGGAAAGTAATTACCTGTAGGAGTTTGCTGAGCTTGAAGAGTGAAAACTGTTGTGAATGAGCCTGATCATAAAACGGACCAGG
CCATTCATTATTCCTCAAGTGTTAATATACTGACTTATGCAGTATTCAAACCATCTAGTGCAATGTTTTTGTTTTTGTTTTTTTTTTGGTAACACAGGTG
CAGTGTATTATAGAAAAAATAAAAACTACAATCATTAGCAGTTTTAATACTGCTGTGTCAGTTTTGTAAAAAATGTACATTATGTCTTTTGACATGTTGA
ATTTTAAACTAGGGAAATGACATTGTAAATCATAGTAGCCTCTTTTAATTTAATATGAAAAATGCCACTATATTGAAAGTACTTAATGTATTGTATATAT
TTCTCTACTTTGGTTCTAGCTATTTTATATGATTGACATGTTATTTAAAAGATAACTGCCTTGAACTTTTGGAGACTTGTACTGTAAATAAAGAAATCTT
AACAATAAACTCAGAATCTACTTACTCCA
- refseq_PIP5K3.F2 (forward primer)
- refseq_PIP5K3.R2 (reverse primer)
- Single exon skipping
Frame 0
QPCKQLRFLPQPSAA*GAHRRSRGPTSGG*AVEAEAGAGGSRRGRGRRRRLMKWPQMIRRPQHWTLL
MICLDLLLVLLISHTLNL*LLIKMSPLLNQLIV
LL*ISFVLTKREQKEARENSSL*VEVGPALSSL
RGHSLLGHPHLIKSSLMRNSSGALQH*TQEGKQN
LPLEVMTLVQLFSFEASAQY*NASRKSWRGKAR
RPPSLHIL*KNSLKLCSFHRQ*FYWGRLECSFR
FCLLCVCA*SK*TPNTCWE*ESQP*HIFRG*FGL
AKFDSSRFLKYSSFNKTCICARGCWEISCSK*I
SQHY*PVTG*IWFSYGTFI*DICQSPG*PNIC*
DRDH*G*TQNSSGQCAVKRPVEKNLPSQQWNGVS
GSPLLVENASQLHCRKGISQLANPKWAYCHKGT
SYSNWTSNG*WTLAGLC*SSRPAFQR*VCAV*T
TAEYRIF*DAFSRQ*LSELRGRTL*AILV*RHKV
**Q*HRTDS*RR*R*FG*FCQS*QAHISQQFPV
HSGQ*LSRFYQPERGAGQRELPYQEALQVPTCA
PSPC*PKRVFDF*HWRTTALNK*RFHQRILI*SP
SRGKIQRAAFHTFGLAS*QPGAPEGGEWGETSH
GEVAFS*S*PHDGTTPAVAP**LTVIILEGHHR
VIGLPGCSDSPT*CQEPG**HGYPSVCPHQKNPR
WKEV*FCGCQWLCLYQEHCT*KDEFLY*KPQNS
SVEVFH*VSLQRRN*VYLH*SYCASGKGILEEL
CPANS*CSTHLGSC*ENSVSDCPGHVIGTWHYFG
H*CKVTSFGTNQSNDPR*FSDVNGPAAYETTPG
HLSQILYADISVA**TNQDTDVF*RLSTAPRLY
NQAKRRL*L*AGSS*GDPNIYDLCCLSFSTRNIL
SHG*ICYASHINAKPFIPFPD*GTRA*GGCPRA
VRWRFHPLGS*HPS*VSAL***QFAGIEDCV*E
G*AGK*KSSAGCCLCEASRT*HNSLPGGSPLCFL
CTCTGIIVATPCG*PTRCFRQRAARDFAANSCA
AGSQKPDKSL*RPSTG*HWIICY*GSHLL*R*T
KDLFFGL*AGIKRCDPLYLPSNHIPRTLSFN*KG
DEMLYPRLFCRAGLLVSSPQ*RIQRNGEQEEET
AAQGSLWTSGHEWKYSGQVYSSLTLT*ASEH*N
C*ASGR*PELG*NAGRLSSQRRKNSAQKFRPFCS
FKGCIKYFKWPIRKQK*G**RERAYSE*CCVVN
KGGLSESH*SPETLCALQQLFCPVQQCS*CLCQ
SLDCNNGILWKE*SYIRNIFREILFQAFLSVSKH
VL*YPHGTSYSALCSWPRLCADNPEGVGFSSTW
ISAYNSYIFLV*NLQTGNTSCCSFQ*VLVYVIC
KIP*T*VLWAPVYSQSQR*ALWSLHPS*LSPVFL
L*PDGGVFQLFSHSAS*SMCSTPQNIH*ASGPI
KSVPSSGSEGLLSKSFTGICCH**KTCIFEN*Y
I**NKRGKNGRYFCTERDGRR*VQELD*EDASKA
HVFLCRYPSATAVGL*VTHCQETKSL*SAASLE
*QVAGPFPTGKG*KETFSSSKSWKTETRGRKQD
KCDGCISTEYFSRTSEWRKRGSLLNNFVQPELHQ
FYSSPIAYAT*SHV*TVSGRAP*ARYSQQFRRC
V*WAFAGIHRQPSEGKVNHESHLCKFASRK*L*
SYSISF*SR*TLLNV*T*TSAHCSLREGTQLHHC
FCSQL*RIPKCLRGIV*SDSVEQCRRRASNK*Y
FR*QTKE*QPYQIT*NEWRTDKSYNRNRTTTNQ
KGFWNVVLLQRDSREKPRSLFPEERDLTWSR*CL
LPGWADGQGGDRESRR*ASR*SRWRRYTKEATH
KSSCGTSIFRC*CQVLLSALLCGRVS*DA*SDS
GQQ*RRFHSFPLPLITLAGPGRQIRSCLLCN*G*
*IYFEANASSGSPVLPRLCTTLLQLYYKCCSTK
EAHGVGQNSWSLQNWL*ELSEQH*EEVRSPCHG
KSFLREKDGTGF*FEGLS*ESECKN*HWKREL*C
GPAR*KSPKDGSRQPSIYSFSFQSCAENLDP**
LPFPF*PPHYRLFFAGWAR*Y*Q*ASSWNYRLY
SNIYMGQKA*DGCEINRNFRWTR*NANSGVSGVV
QD*VL*GNGQVFPNGTRPLDRLGSELLKSSTYF
EMDCEGKGDRNKGPKISYMFYFFIVFTTVCQGF
SVLWLFRLSVMEW*NSMNLHFGF*YLWSCL*VGK
WHENFLKLKYRHVSKG*SWR*VDRVKNGLNLLA
*LF*EENSVS*IDYPGITFNMLST*KAFVELLN
LFCVFL**FNVTYYQNF*NLYKNSDLFH*WPVKH
VGIYCFIEEFDLNWESCHVVYLSSLPVFEYV*C
F*NFVFSVEDRRLQQLTLSLLLEIFLKLV*NFC
AIHILNCTYLHTLIF*GFFSIFRVS**IISK*VC
SY*TLME*LLMKDF*NIKNKLGPIQEIE*EGNT
CFIHRGKVSFQYNQQFRWHL*NKKFLLWTSPFP
TFYIMASSDY*EMLRNRPSAVAHAYNPITLGGLG
RQIT*GQEFKTSLANMTKPHLY*KDKKLAGHGG
IYL*PQLLGWLRQENCLNLGGGGCSELGLHHCI
PAWATEQDCLKKQNETKKESYS**GTSCLIAFLF
ILKSDQK**TIFEEIL*PQNISS*LLFVTRII*
GFIKL*GFHCFWTAYNNSTLTFT**EIWTSSVT
QYDEYLN*EHCGKFALENQGSSLVFGAY*KCGLF
*TGSKLTKDL*LM*C*VPLGPF*KRVCAF*RYT
KH*GF*F*NQRLLKELYRGKKINVEHY*LTLCL
GTMDFVSDLKCQHCFVSVHFFCEDT*GYYSCLFP
VLP*S*ALEVQGVSP*VQLGCFFVFSFNSMCIA
GMLHRNGF*Q*SVLLILFSLPMT*TTVF*STVV
**VTLWQKFSI*YILKQ*LLPCKGNLSF*NWTVL
MKGKYTIYFY*VVELYVWSLAALV*ATIIDIFQ
ILYYSVLSIE*LFPFPSRPRVYSENLGMRKKS*
YFLP*HTT*VPRIIDSSKRKLCQ*HVALYKNLIY
KCEAF*CHQNLLKNRIYFFLILT*EK**EQAVA
SSFVVY*IFYRYSKFPTNYNFFHDLAVSDFLAL
ALIRYCK**GYIDISFCDGIVVISFMTFYPFAVI
LCKTAKESNYL*EFAELEE*KLL*MSLIIKRTR
PFIIPQVLIY*LMQYSNHLVQCFCFCFFFGNTG
AVYYRKNKNYNH*QF*YCCVSFVKNVHYVF*HVE
F*TREMTL*IIVASFNLI*KMPLY*KYLMYCIY
FSTLVLAILYD*HVI*KITALNFWRLVL*IKKS
*Q*TQNLLTP
Frame 1
NHVSSFASCRNRPRPEEPTAALGGRLPGAEPLKRRLGRGAAGAAGAGGADS*NGHR**DVPNTGLC
**FASISY*SFSSHTL*TFDS*SR*APF*ISL*F
FCKSLSF*QRESRRRPGRTAAFEWKLDQPSAPF
EDTVC*VTHTL*KAA**GTPAALFSIRHKKESR
TYLWRS*PSYSCSASKPQHSIKTPQGNHGGEKPG
DLRACTYCRKIALSYAHSTDSNSIGEDLNALSD
SACSVSVLDPSEPRTPVGSRKASRNIFLEDDLA
WQSLIHPDSSNTPLSTRLVSVQEDAGKSPARNRS
ASITNLSLDRSGSPMVPSYETSVSPQANRTYVR
TETTEDERKILLDSVQLKDLWKKICHHSSGMEF
QDHRYWLRTHPNCIVGKELVNWLIRNGHIATRAQ
AIAIGQAMVDGRWLDCVSHHDQLFRDEYALYRP
LQSTEFSETPSPDSDSVNSVEGHSEPSWFKDIK
FDDSDTEQIAEEGDDNLANSASPSKRTSVSSFQS
TVDSDSAASISLNVELDNVNFHIKKPSKYPHVP
PHPADQKEYLISDTGGQQLSISDAFIKESLFNR
RVEEKSKELPFTPLGWHHNNLELLREENGEKQAM
ERLLSANHNHMMALLQQLLHSDSLSSSWRDIIV
SLVCQVVQTVRPDVKNQDDDMDIRQFVHIKKIP
GGKKFDSVVVNGFVCTKNIAHKKMSSCIKNPKIL
LLKCSIEYLYREETKFTCIDPIVLQEREFLKNY
VQRIVDVRPTLVLVEKTVSRIAQDMLLEHGITL
VINVKSQVLERISRMTQGDLVMSMDQLLTKPHLG
TCHKFYMQIFQLPNEQTKTLMFFEGCPQHLGCT
IKLRGGSDYELARVKEILIFMICVAYHSQLEIS
FLMDEFAMPPTLMQNPSFHSLIEGRGHEGAVQEQ
YGGGSIPWDPDIPPESLPCDDSSLLELRIVFEK
GEQENKNLPQAVASVKHQEHSTTACPAGLPCAF
FAPVPESLLPLPVDDQQDALGSEQPETLQQTVVL
QDPKSQIRAFRDPLQDDTGLYVTEEVTSSEDKR
KTYSLAFKQELKDVILCISPVITFREPFLLTEK
GMRCSTRDYFAEQVYWSPLLNKEFKEMENRRKKQ
LLRDLSGLQGMNGSIQAKSIQVLPSHELVSTRI
AEHLGDSQSLGRMLADYRARGGRIQPKNSDPFA
HSKDASSTSSGQSGSKNEGDEERGLILSDAVWST
KVDCLNPINHQRLCVLFSSSSAQSSNAPSACVS
PWIVTMEFYGKNDLTLGIFLERYCFRPSYQCPS
MFCDTPMVHHIRRFVHGQGCVQIILKELDSPVPG
YQHTILTYSWCRICKQVTPVVALSNESWSMSFA
KYLELRFYGHQYTRRANAEPCGHSIHHDYHQYF
SYNQMVASFSYSPIRLLEVCVPLPKIFIKRQAPL
KVSLLQDLKDFFQKVSQVYVAIDERLASLKTDT
FSKTREEKMEDIFAQKEMEEGEFKNWIEKMQAR
LMSSSVDTPQQLQSVFESLIAKKQSLCEVLQAWN
NRLQDLFQQEKGRKRPSVPPSPGRLRQGEESKI
SAMDASPRNISPGLQNGEKEDRFLTTLSSQSST
SSTHLQLPTPPEVMSEQSVGGPPELDTASSSEDV
FDGHLLGSTDSQVKEKSTMKAIFANLLPGNSYN
PIPFPFDPDKHYLMYEHERVPIAVCEKEPSSII
AFALSCKEYRNALEELSKATQWNSAEEGLPTNST
SDSRPKSSSPIRLPEMSGGQTNRTTETEPQPTK
KASGMLSFFRGTAGKSPDLSSQKRETLRGADSA
YYQVGQTGKEGTENQGVEPQDEVDGGDTQKKQLI
NPHVELQFSDANAKFYCRLYYAGEFHKMREVIL
DSSEEDFIRSLSHSSPWQARGGKSGAAFYATED
DRFILKQMPRLEVQSFLDFAPHYFNYITNAVQQK
RPTALAKILGVYRIGYKNSQNNTEKKLDLLVME
NLFYGRKMAQVFDLKGSLRNRNVKTDTGKESCD
VVLLDENLLKMVRDNPLYIRSHSKAVLRTSIHSD
SHFLSSHLIIDYSLLVGRDDTSNELVVGIIDYI
RTFTWDKKLEMVVKSTGILGGQGKMPTVVSPEL
YRTRFCEAMDKYFLMVPDHWTGLGLNC*NQAHIL
KWTVKEKGTGTKDQK*ATCFISSSCSPLYAKAF
QFCGCLDCP*WNGKTP*ICTLVFDTCGAVCRLG
SGMKIFLS*NTDMFQRAKVGDE*IG*KMG*IC*L
NCFKKKTVSHKLTILASHLTCYLLRKHL*SC*I
CFVFFCNNLMLLIIRISETFTKILIYSINGRLN
TWAFIVLLRNLT*TGNPVMLFIFPACLFLSMFDV
FKILSSLWKTGGYSN*L*ASF*RYF*NLFKIFV
QFIY*IALTCIRSYSRVFSLFLGYHSKSLVNES
VVTKP*WNNY**KIFEI*KIN*AQSKKLSEKETL
VLFTEVKCLFNITSNLGGIYKIKNFYCGHPLFQ
LST*WLVLTTKKC*EIGQVRWLTPIILSLWEA*
AGRSPEVRSSRPAWPT*RNPISTKKTKN*LGMVA
YTCNPNYLGG*GRRIV*TWEAEAAVSWDYTIAF
QPGQQSKTVSKNKTKQKKKVILSKELLV**HFC
LF*KVIRSSKLSLRKYCNPRIFPLDFFL*QG*FR
DL*SCKDFTVFGLPIIIAH*PSHNKKSGQVQLH
SMMNT*IRNIVENLL*RIKAVVWYLVLIKNVVC
FELEAS*PRTYD*CDAKFHLAPFKNVYVPFEDTQ
NTEDFSFEIKDY*RSCTEVKK*MWNIINLLCV*
EQWILYLI*NANTVLSLFIFSVRILKVIIPVCF
LYSPSHEHLKYKVSPPRCN*VVSLFLVSILCA*Q
ECSTGMASDNNLSC*FCFPCP*LEQLCFKVL*S
SR*LCGKNFQYNTF*NNSCCLAKVISHFKIGQY
**RGNIQFISIEW*NYMSGPLLLLFRPLS*IYFK
YCTTQC*VLNDCFPFLQGLEYILKI*E*GRNLN
TSFLNIQHESRE*LIVARENYVSNMLLCIKILF
INVKLFDAIKTY*KIGFTFF*F*PKKNNENKLLQ
ALL*SIEYFIDIQNFLQTIIFSMI*Q*VIF*LW
LLLGIVNSRVISISAFVMALWSSAS*HFTHLQ*
SCVKLPRKVITCRSLLSLKSENCCE*A*S*NGPG
HSLFLKC*YTDLCSIQTI*CNVFVFVFFLVTQV
QCIIEKIKTTIISSFNTAVSVL*KMYIMSFDML
NFKLGK*HCKS**PLLI*YEKCHYIEST*CIVYI
SLLWF*LFYMIDMLFKR*LP*TFGDLYCK*RNL
NNKLRIYLL
Frame 2
TM*AASLPAATVRGLRSPPPLSGADFRGLSR*SGGWGGGQPARPGQEAQTHEMATDDKTSPTLDSA
NDLPRSPTSPSHLTHFKPLTPDQDEPPFKSAYS
SFVNLFRFNKERAEGGQGEQQPLSGSWTSPQLPS
RTQSVRSPTPYKKQLNEELQRRSSALDTRRKAE
PTFGGHDPRTAVQLRSLSTVLKRLKEIMEGKSQ
ETSELAHIVEK*P*VMLIPQTVILLGKT*MLFQI
LLALCLCLIQVNPEHLLGVGKPAVTYF*RMIWP
GKV*FIQIPQILLFQQDLYLCKRMLGNLLLEID
QPALLTCHWIDLVLLWYLHMRHLSVPRLTEHMLG
QRPLRMNAKFFWTVCS*KTCGKKSAITAVEWSF
RITATG*ERIPTAL*ERN*STG*SEMGILPQGH
KL*QLDKQWLMDVGWIVLVITTSFSEMSMRCIDH
CRVQNFLRRLLPTVTQ*TPWKDTLSHPGLKT*S
LMTVTQNR*LKKVTIIWLILPVLASAHQSAVSS
PQWTVTQPLLSA*TWSWTT*TSISRSPPSTHMCP
LTLLTKKSI*FLTLEDNSSQ*VTLSSKNPYLIA
E*RKNPKSCLSHLWAGIITTWSS*GRRMGRNKP
WRGCFQLIITT*WHYSSSCSIVTHCHHLGGTSSC
HWSARLFRQSDLMSRTRMMTWISVSLSTSKKSQ
VERSLILWLSMALFVPRTLHIKR*VLVLKTPKF
FC*SVPLSISTEKKLSLLALILLCFRKGNS*RIM
SSE*LMFDPPWFLLRKQCLGLPRTCYWNMALLW
SLM*SHKFWNESVE*PKVI**CQWTSCLRNHTW
ALVTNFICRYFSCLMNKPRH*CFLKVVHST*AVQ
SS*EEALIMSWLELRRS*YL*SVLLIILN*KYP
FSWMNLLCLPH*CKTLHSIP*LRDEGMRGLSKS
STVEVPSPGILTSLLSLCPVMIAVCWN*GLCLRR
VSRKIKIFRRLLPL*SIKNIAQQLARRVSLVLS
LHLYRNHCCHSLWMTNKML*AASSQRLCSKQLC
CRIPKAR*EPLETLYRMTLDYMLLRKSPPLKINE
RLILWPLSRN*KM*SSVSPQ*SHSENPFF*LKR
G*DALPEIILQSRFTGLLSSIKNSKKWRTGGRN
SCSGISLDFRA*MEVFRPSLFKSYPHMS**ALEL
LSIWAIARAWVECWPIIEPEEEEFSPKIQTLLL
IQRMHQVLQVANQEAKMRVMKREGLF*VMLCGQ
QRWTV*IPLITRDFVCSSAALLPSPAMLLVPVSV
LGL*QWNFMERMILH*EYF*RDTVSGLLISVQA
CSVIPPWYIIFGALFMAKAVCR*S*RSWILQYL
DISIQFLHIPGVESANR*HQLLLFPMSPGLCHLQ
NTLNLGFMGTSILAEPTLSPVVTPSIMIITSIS
PITRWWRLSVILPFGFLKYVFHSPKYSLSVRPH
*KCPFFRI*RTSFKKFHRYMLPLMKDLHL*KLIH
LVKQERKKWKIFLHRKRWKKVSSRTGLRRCKQG
SCLPL*IPLSNCSRSLSHSLPRNKVSVKCCKLG
ITGCRTFSNRKRVERDLQFLQVLED*DKGKKAR*
VRWMHLHGIFLQDFRMEKKRIAS*QLCPARAPP
VLLISNCLRHLKSCLNSQWEGPLS*IQPAVPKM
CLMGICWDPQTAK*RKSQP*KPSLQICFQEIAII
LFHFLLIQINTT*CMNMNECPLQSARRNPAPSL
LLLSVVKNTEMP*RNCLKRLSGTVPKKGFQQIV
LQIADQRVAALSDYLK*VEDRQIVQQKQNHNQPK
RLLECCPSSEGQQGKAPISLPRRERPYVEQIVL
TTRLGRRARRGPRIKALSLKMK*MEEIHKRSNS
*ILMWNFNFQMLMPSFTVGSTMRESFIRCVK*FW
TAVKKISFVPSPTHHPGRPGEANQELPSMQLRM
IDLF*SKCLVWKSSPSSTLHHITSIILQMLFNK
RGPRRWPKFLEFTELVIRTLRTTLRRS*ISLSWK
IFSTGERWHRFLI*RALLGIGM*KLTLEKRVVM
WSC*MKIS*RWFETTLYIFVLIPKLC*EPRSIV
TPISFLATSL*IILCWLGEMILAMS**LEL*IIF
EHLHGTKSLRWL*NQQEF*VDKVKCQQWCLRSC
TGLGFVRQWTSIS*WYQTTGQAWV*IAEIKHIF
*NGL*RKRGQEQRTKNKLHVLFLHRVHHCMPRLF
SSVAV*TVRNGMVKLHEFALWFLIPVELSVGWE
VA*KFS*AKIQTCFKGLKLEMSR*GEKWVKFAS
LIVLRRKQCLIN*LSWHHI*HVIYLESICRAAEF
VLCFSVII*CYLLSEFLKPLQKF*FIPLMAG*T
RGHLLFY*GI*LKLGILSCCLSFQLACF*VCLM
FLKFCLLCGRQEATAINFKPPFRDIFKTCLKFLC
NSYIKLHLLAYAHILGFFLYF*GIIVNH**MSL
*LLNPNGIIINERFLKYKK*IRPNPRN*VRRKH
LFYSQR*SVFSI*PAI*VASIK*KISTVDIPFSN
FLHNG*F*LLRNVKK*AKCGGSRL*SYHFGRPR
QADHLRSGVQDQPGQHDETPSLLKRQKISWAWW
HIPVTPTTWVAEAGELFEPGRRRLQ*AGITPLHS
SLGNRARLSQKTKRNKKRKLFLVRNFLFNSIFV
YFKK*SEVVNYL*GNTVTPEYFLLTSFCNKDNL
GIYKVVRISLFLDCL***HINLHIIRNLDKFSYT
V**ILELGTLWKICFRESRQ*FGIWCLLKMWFV
LNWKQVDQGLMTNVMLSSTWPLLKTCMCLLKIH
KTLRILVLKSKTIKGAVQR*KNKCGTLLTYFVSR
NNGFCI*FKMPTLFCLCSFFL*GYLRLLFLSVS
CTPLVMST*STRCLPLGAIRLFLCF*FQFYVHS
RNAPQEWLLTIICPVDFVFLAHDLNNCVLKYCSL
VGNFVAKIFNIIHSETIVAALQR*SLILKLDSI
NEGEIYNLFLLSGRTICLVPCCSCLGHYHRYIS
NIVLLSVKY*MTVSLSFKA*SIF*KFRNEEEILI
LPSLTYNMSPENN***QEKTMSVTCCFV*KSYL
*M*SFLMPSKLIKK*DLLFSNSDLRKIMRTSCC
KLFCSLLNIL*IFKISYKL*FFP*FSSE*FSSFG
SY*VL*IVGLYRYQLL*WHCGHQLHDILPICSD
PV*NCQGK*LPVGVC*A*RVKTVVNEPDHKTDQ
AIHYSSSVNILTYAVFKPSSAMFLFLFFFW*HRC
SVL*KK*KLQSLAVLILLCQFCKKCTLCLLTC*
ILN*GNDIVNHSSLF*FNMKNATILKVLNVLYI
FLYFGSSYFI*LTCYLKDNCLELLETCTVNKEIL
TINSESTYS
Sequence NM_015040
CAACCATGTAAGCAGCTTCGCTTCCTGCCGCAACCGTCCGCGGCCTGAGGAGCCCACCGCCGCTCTCGGGGGCCGACTTCCGGGGGCTGAGCCGTTGAAGCGGAGGCTGGGGCGGGGGGCAGCCGGCGCGGCCGGGGCAGGAGGCGCAGACTCATGAAATGGCCACAGATGATAAGACGTCCCCAACACTGGACTCTGCT
AATGATTTGCCTCGATCTCCTACTAGTCCTTCTCATCTCACACACTTTAAACCTTTGACTCCTGATCAAGATGAGCCCCCTTTTAAATCAGCTTATAGTT
CTTTTGTAAATCTCTTTCGTTTTAACAAAGAGAGAGCAGAAGGAGGCCAGGGAGAACAGCAGCCTTTGAGTGGAAGTTGGACCAGCCCTCAGCTCCCTTC
GAGGACACAGTCTGTTAGGTCACCCACACCTTATAAAAAGCAGCTTAATGAGGAACTCCAGCGGCGCTCTTCAGCATTAGACACAAGAAGGAAAGCAGAA
CCTACCTTTGGAGGTCATGACCCTCGTACAGCTGTTCAGCTTCGAAGCCTCAGCACAGTATTAAAACGCCTCAAGGAAATCATGGAGGGGAAAAGCCAGG
ATAGTGACCTGAAACAATACTGGATGCCAGATAGCCAATGTAAAGAGTGCTATGACTGTAGTGAGAAATTTACAACCTTTAGGCGCAGACACCATTGCCG
ACTATGTGGGCAGATTTTCTGCAGTCGTTGCTGTAATCAAGAAATCCCTGGAAAATTTATGGGCTATACAGGAGACCTCCGAGCTTGCACATATTGTAGA
AAAATAGCCTTAAGTTATGCTCATTCCACAGACAGTAATTCTATTGGGGAAGACTTGAATGCTCTTTCAGATTCTGCTTGCTCTGTGTCTGTGCTTGATC
CAAGTGAACCCCGAACACCTGTTGGGAGTAGGAAAGCCAGCCGTAACATATTTTTAGAGGATGATTTGGCCTGGCAAAGTTTGATTCATCCAGATTCCTC
AAATACTCCTCTTTCAACAAGACTTGTATCTGTGCAAGAGGATGCTGGGAAATCTCCTGCTCGAAATAGATCAGCCAGCATTACTAACCTGTCACTGGAT
AGATCTGGTTCTCCTATGGTACCTTCATATGAGACATCTGTCAGTCCCCAGGCTAACCGAACATATGTTAGGACAGAGACCACTGAGGATGAACGCAAAA
TTCTTCTGGACAGTGTGCAGTTAAAAGACCTGTGGAAAAAAATCTGCCATCACAGCAGTGGAATGGAGTTTCAGGATCACCGCTACTGGTTGAGAACGCA
TCCCAACTGCATTGTAGGAAAGGAATTAGTCAACTGGCTAATCCGAAATGGGCATATTGCCACAAGGGCACAAGCTATAGCAATTGGACAAGCAATGGTT
GATGGACGTTGGCTGGATTGTGTTAGTCATCACGACCAGCTTTTCAGAGATGAGTATGCGCTGTATAGACCACTGCAGAGTACAGAATTTTCTGAGACGC
CTTCTCCCGACAGTGACTCAGTGAACTCCGTGGAAGGACACTCTGAGCCATCCTGGTTTAAAGACATAAAGTTTGATGACAGTGACACAGAACAGATAGC
TGAAGAAGGTGACGATAATTTGGCTAATTCTGCCAGTCCTAGCAAGCGCACATCAGTCAGCAGTTTCCAGTCCACAGTGGACAGTGACTCAGCCGCTTCT
ATCAGCCTGAACGTGGAGCTGGACAACGTGAACTTCCATATCAAGAAGCCCTCCAAGTACCCACATGTGCCCCCTCACCCTGCTGACCAAAAAGAGTATT
TGATTTCTGACACTGGAGGACAACAGCTCTCAATAAGTGACGCTTTCATCAAAGAATCCTTATTTAATCGCCGAGTAGAGGAAAAATCCAAAGAGCTGCC
TTTCACACCTTTGGGCTGGCATCATAACAACCTGGAGCTCCTGAGGGAGGAGAATGGGGAGAAACAAGCCATGGAGAGGTTGCTTTCAGCTAATCATAAC
CACATGATGGCACTACTCCAGCAGTTGCTCCATAGTGACTCACTGTCATCATCTTGGAGGGACATCATCGTGTCATTGGTCTGCCAGGTTGTTCAGACAG
TCCGACCTGATGTCAAGAACCAGGATGATGACATGGATATCCGTCAGTTTGTCCACATCAAAAAAATCCCAGGTGGAAAGAAGTTTGATTCTGTGGTTGT
CAATGGCTTTGTTTGTACCAAGAACATTGCACATAAAAAGATGAGTTCTTGTATTAAAAACCCCAAAATTCTTCTGTTGAAGTGTTCCATTGAGTATCTC
TACAGAGAAGAAACTAAGTTTACTTGCATTGATCCTATTGTGCTTCAGGAAAGGGAATTCTTGAAGAATTATGTCCAGCGAATAGTTGATGTTCGACCCA
CCTTGGTTCTTGTTGAGAAAACAGTGTCTCGGATTGCCCAGGACATGTTATTGGAACATGGCATTACTTTGGTCATTAATGTAAAGTCACAAGTTTTGGA
ACGAATCAGTCGAATGACCCAAGGTGATTTAGTGATGTCAATGGACCAGCTGCTTACGAAACCACACCTGGGCACTTGTCACAAATTTTATATGCAGATA
TTTCAGTTGCCTAATGAACAAACCAAGACACTGATGTTTTTTGAAGGTTGTCCACAGCACCTAGGCTGTACAATCAAGCTAAGAGGAGGCTCTGATTATG
AGCTGGCTCGAGTTAAGGAGATCCTAATATTTATGATCTGTGTTGCTTATCATTCTCAACTAGAAATATCCTTTCTCATGGATGAATTTGCTATGCCTCC
CACATTAATGCAAAACCCTTCATTCCATTCCCTGATTGAGGGACGAGGGCATGAGGGGGCTGTCCAAGAGCAGTACGGTGGAGGTTCCATCCCCTGGGAT
CCTGACATCCCTCCTGAGTCTCTGCCCTGTGATGATAGCAGTTTGCTGGAATTGAGGATTGTGTTTGAGAAGGGTGAGCAGGAAAATAAAAATCTTCCGC
AGGCTGTTGCCTCTGTGAAGCATCAAGAACATAGCACAACAGCTTGCCCGGCGGGTCTCCCTTGTGCTTTCTTTGCACCTGTACCGGAATCATTGTTGCC
ACTCCCTGTGGATGACCAACAAGATGCTTTAGGCAGCGAGCAGCCAGAGACTTTGCAGCAAACAGTTGTGCTGCAGGATCCCAAAAGCCAGATAAGAGCC
TTTAGAGACCCTCTACAGGATGACACTGGATTATATGTTACTGAGGAAGTCACCTCCTCTGAAGATAAACGAAAGACTTATTCTTTGGCCTTTAAGCAGG
AATTAAAAGATGTGATCCTCTGTATCTCCCCAGTAATCACATTCCGAGAACCCTTTCTTTTAACTGAAAAGGGGATGAGATGCTCTACCCGAGATTATTT
TGCAGAGCAGGTTTACTGGTCTCCTCTCCTCAATAAAGAATTCAAAGAAATGGAGAACAGGAGGAAGAAACAGCTGCTCAGGGATCTCTCTGGACTTCAG
GGCATGAATGGAAGTATTCAGGCCAAGTCTATTCAAGTCTTACCCTCACATGAGCTAGTGAGCACTAGAATTGCTGAGCATCTGGGCGATAGCCAGAGCT
TGGGTAGAATGCTGGCCGATTATCGAGCCAGAGGAGGAAGAATTCAGCCCAAAAATTCAGACCCTTTTGCTCATTCAAAGGATGCATCAAGTACTTCAAG
TGGCCAATCAGGAAGCAAAAATGAGGGTGATGAAGAGAGAGGGCTTATTCTGAGTGATGCTGTGTGGTCAACAAAGGTGGACTGTCTGAATCCCATTAAT
CACCAGAGACTTTGTGTGCTCTTCAGCAGCTCTTCTGCCCAGTCCAGCAATGCTCCTAGTGCCTGTGTCAGTCCTTGGATTGTAACAATGGAATTTTATG
GAAAGAATGATCTTACATTAGGAATATTTTTAGAGAGATACTGTTTCAGGCCTTCTTATCAGTGTCCAAGCATGTTCTGTGATACCCCCATGGTACATCA
TATTCGGCGCTTTGTTCATGGCCAAGGCTGTGTGCAGATAATCCTGAAGGAGTTGGATTCTCCAGTACCTGGATATCAGCATACAATTCTTACATATTCC
TGGTGTAGAATCTGCAAACAGGTAACACCAGTTGTTGCTCTTTCCAATGAGTCCTGGTCTATGTCATTTGCAAAATACCTTGAACTTAGGTTTTATGGGC
ACCAGTATACTCGCAGAGCCAACGCTGAGCCCTGTGGTCACTCCATCCATCATGATTATCACCAGTATTTCTCCTATAACCAGATGGTGGCGTCTTTCAG
TTATTCTCCCATTCGGCTTCTTGAAGTATGTGTTCCACTCCCCAAAATATTCATTAAGCGTCAGGCCCCATTAAAAGTGTCCCTTCTTCAGGATCTGAAG
GACTTCTTTCAAAAAGTTTCACAGGTATATGTTGCCATTGATGAAAGACTTGCATCTTTGAAAACTGATACATTTAGTAAAACAAGAGAGGAAAAAATGG
AAGATATTTTTGCACAGAAAGAGATGGAAGAAGGTGAGTTCAAGAACTGGATTGAGAAGATGCAAGCAAGGCTCATGTCTTCCTCTGTAGATACCCCTCA
GCAACTGCAGTCGGTCTTTGAGTCACTCATTGCCAAGAAACAAAGTCTCTGTGAAGTGCTGCAAGCTTGGAATAACAGGTTGCAGGACCTTTTCCAACAG
GAAAAGGGTAGAAAGAGACCTTCAGTTCCTCCAAGTCCTGGAAGACTGAGACAAGGGGAAGAAAGCAAGATAAGTGCGATGGATGCATCTCCACGGAATA
TTTCTCCAGGACTTCAGAATGGAGAAAAAGAGGATCGCTTCTTAACAACTTTGTCCAGCCAGAGCTCCACCAGTTCTACTCATCTCCAATTGCCTACGCC
ACCTGAAGTCATGTCTGAACAGTCAGTGGGAGGGCCCCCTGAGCTAGATACAGCCAGCAGTTCCGAAGATGTGTTTGATGGGCATTTGCTGGGATCCACA
GACAGCCAAGTGAAGGAAAAGTCAACCATGAAAGCCATCTTTGCAAATTTGCTTCCAGGAAATAGCTATAATCCTATTCCATTTCCTTTTGATCCAGATA
AACACTACTTAATGTATGAACATGAACGAGTGCCCATTGCAGTCTGCGAGAAGGAACCCAGCTCCATCATTGCTTTTGCTCTCAGTTGTAAAGAATACCG
AAATGCCTTAGAGGAATTGTCTAAAGCGACTCAGTGGAACAGTGCCGAAGAAGGGCTTCCAACAAATAGTACTTCAGATAGCAGACCAAAGAGTAGCAGC
CCTATCAGATTACCTGAAATGAGTGGAGGACAGACAAATCGTACAACAGAAACAGAACCACAACCAACCAAAAAGGCTTCTGGAATGTTGTCCTTCTTCA
GAGGGACAGCAGGGAAAAGCCCCGATCTCTCTTCCCAGAAGAGAGAGACCTTACGTGGAGCAGATAGTGCTTACTACCAGGTTGGGCAGACGGGCAAGGA
GGGGACCGAGAATCAAGGCGTTGAGCCTCAAGATGAAGTAGATGGAGGAGATACACAAAAGAAGCAACTCATAAATCCTCATGTGGAACTTCAATTTTCA
GATGCTAATGCCAAGTTTTACTGTCGGCTCTACTATGCGGGAGAGTTTCATAAGATGCGTGAAGTGATTCTGGACAGCAGTGAAGAAGATTTCATTCGTT
CCCTCTCCCACTCATCACCCTGGCAGGCCCGGGGAGGCAAATCAGGAGCTGCCTTCTATGCAACTGAGGATGATAGATTTATTTTGAAGCAAATGCCTCG
TCTGGAAGTCCAGTCCTTCCTCGACTTTGCACCACATTACTTCAATTATATTACAAATGCTGTTCAACAAAAGAGGCCCACGGCGTTGGCCAAAATTCTT
GGAGTTTACAGAATTGGTTATAAGAACTCTCAGAACAACACTGAGAAGAAGTTAGATCTCCTTGTCATGGAAAATCTTTTCTACGGGAGAAAGATGGCAC
AGGTTTTTGATTTGAAGGGCTCTCTTAGGAATCGGAATGTAAAAACTGACACTGGAAAAGAGAGTTGTGATGTGGTCCTGCTAGATGAAAATCTCCTAAA
GATGGTTCGAGACAACCCTCTATATATTCGTTCTCATTCCAAAGCTGTGCTGAGAACCTCGATCCATAGTGACTCCCATTTCCTTTCTAGCCACCTCATT
ATAGATTATTCTTTGCTGGTTGGGCGAGATGATACTAGCAATGAGCTAGTAGTTGGAATTATAGATTATATTCGAACATTTACATGGGACAAAAAGCTTG
AGATGGTTGTGAAATCAACAGGAATTTTAGGTGGACAAGGTAAAATGCCAACAGTGGTGTCTCCGGAGTTGTACAGGACTAGGTTTTGTGAGGCAATGGA
CAAGTATTTCCTAATGGTACCAGACCACTGGACAGGCTTGGGTCTGAATTGCTGAAATCAAGCACATATTTTGAAATGGACTGTGAAGGAAAAGGGGACA
GGAACAAAGGACCAAAAATAAGCTACATGTTTTATTTCTTCATCGTGTTCACCACTGTATGCCAAGGCTTTTCAGTTCTGTGGCTGTTTAGACTGTCCGT
AATGGAATGGTAAAACTCCATGAATTTGCACTTTGGTTTTTGATACCTGTGGAGCTGTCTGTAGGTTGGGAAGTGGCATGAAAATTTTCTTAAGCTAAAA
TACAGACATGTTTCAAAGGGCTAAAGTTGGAGATGAGTAGATAGGGTGAAAAATGGGTTAAATTTGCTAGCTTAATTGTTTTAAGAAGAAAACAGTGTCT
CATAAATTGACTATCCTGGCATCACATTTAACATGTTATCTACTTAGAAAGCATTTGTAGAGCTGCTGAATTTGTTTTGTGTTTTTCTGTAATAATTTAA
TGTTACTTATTATCAGAATTTCTGAAACCTTTACAAAAATTCTGATTTATTCCATTAATGGCCGGTTAAACACGTGGGCATTTATTGTTTTATTGAGGAA
TTTGACTTAAACTGGGAATCCTGTCATGTTGTTTATCTTTCCAGCTTGCCTGTTTTTGAGTATGTTTGATGTTTTTAAAATTTTGTCTTCTCTGTGGAAG
ACAGGAGGCTACAGCAATTAACTTTAAGCCTCCTTTTAGAGATATTTTTAAAACTTGTTTAAAATTTTTGTGCAATTCATATATTAAATTGCACTTACTT
GCATACGCTCATATTCTAGGGTTTTTTCTCTATTTTTAGGGTATCATAGTAAATCATTAGTAAATGAGTCTGTAGTTACTAAACCCTAATGGAATAATTA
TTAATGAAAGATTTTTGAAATATAAAAAATAAATTAGGCCCAATCCAAGAAATTGAGTGAGAAGGAAACACTTGTTTTATTCACAGAGGTAAAGTGTCTT
TTCAATATAACCAGCAATTTAGGTGGCATCTATAAAATAAAAAATTTCTACTGTGGACATCCCCTTTTCCAACTTTCTACATAATGGCTAGTTCTGACTA
CTAAGAAATGTTAAGAAATAGGCCAAGTGCGGTGGCTCACGCCTATAATCCTATCACTTTGGGAGGCCTAGGCAGGCAGATCACCTGAGGTCAGGAGTTC
AAGACCAGCCTGGCCAACATGACGAAACCCCATCTCTACTAAAAAGACAAAAAATTAGCTGGGCATGGTGGCATATACCTGTAACCCCAACTACTTGGGT
GGCTGAGGCAGGAGAATTGTTTGAACCTGGGAGGCGGAGGCTGCAGTGAGCTGGGATTACACCATTGCATTCCAGCCTGGGCAACAGAGCAAGACTGTCT
CAAAAAACAAAACGAAACAAAAAAAGAAAGTTATTCTTAGTAAGGAACTTCTTGTTTAATAGCATTTTTGTTTATTTTAAAAAGTGATCAGAAGTAGTAA
ACTATCTTTGAGGAAATACTGTAACCCCAGAATATTTCCTCTTGACTTCTTTTTGTAACAAGGATAATTTAGGGATTTATAAAGTTGTAAGGATTTCACT
GTTTTTGGACTGCCTATAATAATAGCACATTAACCTTCACATAATAAGAAATCTGGACAAGTTCAGTTACACAGTATGATGAATACTTGAATTAGGAACA
TTGTGGAAAATTTGCTTTAGAGAATCAAGGCAGTAGTTTGGTATTTGGTGCTTATTAAAAATGTGGTTTGTTTTGAACTGGAAGCAAGTTGACCAAGGAC
TTATGACTAATGTGATGCTAAGTTCCACTTGGCCCCTTTTAAAAACGTGTATGTGCCTTTTGAAGATACACAAAACACTGAGGATTTTAGTTTTGAAATC
AAAGACTATTAAAGGAGCTGTACAGAGGTAAAAAAATAAATGTGGAACATTATTAACTTACTTTGTGTCTAGGAACAATGGATTTTGTATCTGATTTAAA
ATGCCAACACTGTTTTGTCTCTGTTCATTTTTTCTGTGAGGATACTTAAGGTTATTATTCCTGTCTGTTTCCTGTACTCCCCTAGTCATGAGCACTTGAA
GTACAAGGTGTCTCCCCCTAGGTGCAATTAGGTTGTTTCTTTGTTTTTAGTTTCAATTCTATGTGCATAGCAGGAATGCTCCACAGGAATGGCTTCTGAC
AATAATCTGTCCTGTTGATTTTGTTTTCCTTGCCCATGACTTGAACAACTGTGTTTTAAAGTACTGTAGTCTAGTAGGTAACTTTGTGGCAAAAATTTTC
AATATAATACATTCTGAAACAATAGTTGCTGCCTTGCAAAGGTAATCTCTCATTTTAAAATTGGACAGTATTAATGAAGGGGAAATATACAATTTATTTC
TATTGAGTGGTAGAACTATATGTCTGGTCCCTTGCTGCTCTTGTTTAGGCCACTATCATAGATATATTTCAAATATTGTACTACTCAGTGTTAAGTATTG
AATGACTGTTTCCCTTTCCTTCAAGGCCTAGAGTATATTCTGAAAATTTAGGAATGAGGAAGAAATCTTAATACTTCCTTCCTTAACATACAACATGAGT
CCCGAGAATAATTGATAGTAGCAAGAGAAAACTATGTCAGTAACATGTTGCTTTGTATAAAAATCTTATTTATAAATGTGAAGCTTTTTGATGCCATCAA
AACTTATTAAAAAATAGGATTTACTTTTTTCTAATTCTGACCTAAGAAAAATAATGAGAACAAGCTGTTGCAAGCTCTTTTGTAGTCTATTGAATATTTT
ATAGATATTCAAAATTTCCTACAAACTATAATTTTTTCCATGATTTAGCAGTGAGTGATTTTCTAGCTTTGGCTCTTATTAGGTATTGTAAATAGTAGGG
TTATATCGATATCAGCTTTTGTGATGGCATTGTGGTCATCAGCTTCATGACATTTTACCCATTTGCAGTGATCCTGTGTAAAACTGCCAAGGAAAGTAAT
TACCTGTAGGAGTTTGCTGAGCTTGAAGAGTGAAAACTGTTGTGAATGAGCCTGATCATAAAACGGACCAGGCCATTCATTATTCCTCAAGTGTTAATAT
ACTGACTTATGCAGTATTCAAACCATCTAGTGCAATGTTTTTGTTTTTGTTTTTTTTTTGGTAACACAGGTGCAGTGTATTATAGAAAAAATAAAAACTA
CAATCATTAGCAGTTTTAATACTGCTGTGTCAGTTTTGTAAAAAATGTACATTATGTCTTTTGACATGTTGAATTTTAAACTAGGGAAATGACATTGTAA
ATCATAGTAGCCTCTTTTAATTTAATATGAAAAATGCCACTATATTGAAAGTACTTAATGTATTGTATATATTTCTCTACTTTGGTTCTAGCTATTTTAT
ATGATTGACATGTTATTTAAAAGATAACTGCCTTGAACTTTTGGAGACTTGTACTGTAAATAAAGAAATCTTAACAATAAACTCAGAATCTACTTACTCC
A
- refseq_PIP5K3.F2 (forward primer)
- refseq_PIP5K3.R2 (reverse primer)
- Single exon skipping
Frame 0
QPCKQLRFLPQPSAA*GAHRRSRGPTSGG*AVEAEAGAGGSRRGRGRRRRLMKWPQMIRRPQHWTLL
MICLDLLLVLLISHTLNL*LLIKMSPLLNQLIV
LL*ISFVLTKREQKEARENSSL*VEVGPALSSL
RGHSLLGHPHLIKSSLMRNSSGALQH*TQEGKQN
LPLEVMTLVQLFSFEASAQY*NASRKSWRGKAR
IVT*NNTGCQIANVKSAMTVVRNLQPLGADTIA
DYVGRFSAVVAVIKKSLENLWAIQETSELAHIVE
K*P*VMLIPQTVILLGKT*MLFQILLALCLCLI
QVNPEHLLGVGKPAVTYF*RMIWPGKV*FIQIP
QILLFQQDLYLCKRMLGNLLLEIDQPALLTCHWI
DLVLLWYLHMRHLSVPRLTEHMLGQRPLRMNAK
FFWTVCS*KTCGKKSAITAVEWSFRITATG*ER
IPTAL*ERN*STG*SEMGILPQGHKL*QLDKQWL
MDVGWIVLVITTSFSEMSMRCIDHCRVQNFLRR
LLPTVTQ*TPWKDTLSHPGLKT*SLMTVTQNR*
LKKVTIIWLILPVLASAHQSAVSSPQWTVTQPLL
SA*TWSWTT*TSISRSPPSTHMCPLTLLTKKSI
*FLTLEDNSSQ*VTLSSKNPYLIAE*RKNPKSC
LSHLWAGIITTWSS*GRRMGRNKPWRGCFQLIIT
T*WHYSSSCSIVTHCHHLGGTSSCHWSARLFRQ
SDLMSRTRMMTWISVSLSTSKKSQVERSLILWL
SMALFVPRTLHIKR*VLVLKTPKFFC*SVPLSIS
TEKKLSLLALILLCFRKGNS*RIMSSE*LMFDP
PWFLLRKQCLGLPRTCYWNMALLWSLM*SHKFW
NESVE*PKVI**CQWTSCLRNHTWALVTNFICRY
FSCLMNKPRH*CFLKVVHST*AVQSS*EEALIM
SWLELRRS*YL*SVLLIILN*KYPFSWMNLLCL
PH*CKTLHSIP*LRDEGMRGLSKSSTVEVPSPGI
LTSLLSLCPVMIAVCWN*GLCLRRVSRKIKIFR
RLLPL*SIKNIAQQLARRVSLVLSLHLYRNHCC
HSLWMTNKML*AASSQRLCSKQLCCRIPKAR*EP
LETLYRMTLDYMLLRKSPPLKINERLILWPLSR
N*KM*SSVSPQ*SHSENPFF*LKRG*DALPEII
LQSRFTGLLSSIKNSKKWRTGGRNSCSGISLDFR
A*MEVFRPSLFKSYPHMS**ALELLSIWAIARA
WVECWPIIEPEEEEFSPKIQTLLLIQRMHQVLQ
VANQEAKMRVMKREGLF*VMLCGQQRWTV*IPLI
TRDFVCSSAALLPSPAMLLVPVSVLGL*QWNFM
ERMILH*EYF*RDTVSGLLISVQACSVIPPWYI
IFGALFMAKAVCR*S*RSWILQYLDISIQFLHIP
GVESANR*HQLLLFPMSPGLCHLQNTLNLGFMG
TSILAEPTLSPVVTPSIMIITSISPITRWWRLS
VILPFGFLKYVFHSPKYSLSVRPH*KCPFFRI*R
TSFKKFHRYMLPLMKDLHL*KLIHLVKQERKKW
KIFLHRKRWKKVSSRTGLRRCKQGSCLPL*IPL
SNCSRSLSHSLPRNKVSVKCCKLGITGCRTFSNR
KRVERDLQFLQVLED*DKGKKAR*VRWMHLHGI
FLQDFRMEKKRIAS*QLCPARAPPVLLISNCLR
HLKSCLNSQWEGPLS*IQPAVPKMCLMGICWDPQ
TAK*RKSQP*KPSLQICFQEIAIILFHFLLIQI
NTT*CMNMNECPLQSARRNPAPSLLLLSVVKNT
EMP*RNCLKRLSGTVPKKGFQQIVLQIADQRVAA
LSDYLK*VEDRQIVQQKQNHNQPKRLLECCPSS
EGQQGKAPISLPRRERPYVEQIVLTTRLGRRAR
RGPRIKALSLKMK*MEEIHKRSNS*ILMWNFNFQ
MLMPSFTVGSTMRESFIRCVK*FWTAVKKISFV
PSPTHHPGRPGEANQELPSMQLRMIDLF*SKCL
VWKSSPSSTLHHITSIILQMLFNKRGPRRWPKFL
EFTELVIRTLRTTLRRS*ISLSWKIFSTGERWH
RFLI*RALLGIGM*KLTLEKRVVMWSC*MKIS*
RWFETTLYIFVLIPKLC*EPRSIVTPISFLATSL
*IILCWLGEMILAMS**LEL*IIFEHLHGTKSL
RWL*NQQEF*VDKVKCQQWCLRSCTGLGFVRQW
TSIS*WYQTTGQAWV*IAEIKHIF*NGL*RKRGQ
EQRTKNKLHVLFLHRVHHCMPRLFSSVAV*TVR
NGMVKLHEFALWFLIPVELSVGWEVA*KFS*AK
IQTCFKGLKLEMSR*GEKWVKFASLIVLRRKQCL
IN*LSWHHI*HVIYLESICRAAEFVLCFSVII*
CYLLSEFLKPLQKF*FIPLMAG*TRGHLLFY*G
I*LKLGILSCCLSFQLACF*VCLMFLKFCLLCGR
QEATAINFKPPFRDIFKTCLKFLCNSYIKLHLL
AYAHILGFFLYF*GIIVNH**MSL*LLNPNGII
INERFLKYKK*IRPNPRN*VRRKHLFYSQR*SVF
SI*PAI*VASIK*KISTVDIPFSNFLHNG*F*L
LRNVKK*AKCGGSRL*SYHFGRPRQADHLRSGV
QDQPGQHDETPSLLKRQKISWAWWHIPVTPTTWV
AEAGELFEPGRRRLQ*AGITPLHSSLGNRARLS
QKTKRNKKRKLFLVRNFLFNSIFVYFKK*SEVV
NYL*GNTVTPEYFLLTSFCNKDNLGIYKVVRISL
FLDCL***HINLHIIRNLDKFSYTV**ILELGT
LWKICFRESRQ*FGIWCLLKMWFVLNWKQVDQG
LMTNVMLSSTWPLLKTCMCLLKIHKTLRILVLKS
KTIKGAVQR*KNKCGTLLTYFVSRNNGFCI*FK
MPTLFCLCSFFL*GYLRLLFLSVSCTPLVMST*
STRCLPLGAIRLFLCF*FQFYVHSRNAPQEWLLT
IICPVDFVFLAHDLNNCVLKYCSLVGNFVAKIF
NIIHSETIVAALQR*SLILKLDSINEGEIYNLF
LLSGRTICLVPCCSCLGHYHRYISNIVLLSVKY*
MTVSLSFKA*SIF*KFRNEEEILILPSLTYNMS
PENN***QEKTMSVTCCFV*KSYL*M*SFLMPS
KLIKK*DLLFSNSDLRKIMRTSCCKLFCSLLNIL
*IFKISYKL*FFP*FSSE*FSSFGSY*VL*IVG
LYRYQLL*WHCGHQLHDILPICSDPV*NCQGK*
LPVGVC*A*RVKTVVNEPDHKTDQAIHYSSSVNI
LTYAVFKPSSAMFLFLFFFW*HRCSVL*KK*KL
QSLAVLILLCQFCKKCTLCLLTC*ILN*GNDIV
NHSSLF*FNMKNATILKVLNVLYIFLYFGSSYFI
*LTCYLKDNCLELLETCTVNKEILTINSESTYS
Frame 1
NHVSSFASCRNRPRPEEPTAALGGRLPGAEPLKRRLGRGAAGAAGAGGADS*NGHR**DVPNTGLC
**FASISY*SFSSHTL*TFDS*SR*APF*ISL*F
FCKSLSF*QRESRRRPGRTAAFEWKLDQPSAPF
EDTVC*VTHTL*KAA**GTPAALFSIRHKKESR
TYLWRS*PSYSCSASKPQHSIKTPQGNHGGEKPG
**PETILDAR*PM*RVL*L**EIYNL*AQTPLP
TMWADFLQSLL*SRNPWKIYGLYRRPPSLHIL*
KNSLKLCSFHRQ*FYWGRLECSFRFCLLCVCA*S
K*TPNTCWE*ESQP*HIFRG*FGLAKFDSSRFL
KYSSFNKTCICARGCWEISCSK*ISQHY*PVTG
*IWFSYGTFI*DICQSPG*PNIC*DRDH*G*TQN
SSGQCAVKRPVEKNLPSQQWNGVSGSPLLVENA
SQLHCRKGISQLANPKWAYCHKGTSYSNWTSNG
*WTLAGLC*SSRPAFQR*VCAV*TTAEYRIF*DA
FSRQ*LSELRGRTL*AILV*RHKV**Q*HRTDS
*RR*R*FG*FCQS*QAHISQQFPVHSGQ*LSRF
YQPERGAGQRELPYQEALQVPTCAPSPC*PKRVF
DF*HWRTTALNK*RFHQRILI*SPSRGKIQRAA
FHTFGLAS*QPGAPEGGEWGETSHGEVAFS*S*
PHDGTTPAVAP**LTVIILEGHHRVIGLPGCSDS
PT*CQEPG**HGYPSVCPHQKNPRWKEV*FCGC
QWLCLYQEHCT*KDEFLY*KPQNSSVEVFH*VS
LQRRN*VYLH*SYCASGKGILEELCPANS*CSTH
LGSC*ENSVSDCPGHVIGTWHYFGH*CKVTSFG
TNQSNDPR*FSDVNGPAAYETTPGHLSQILYAD
ISVA**TNQDTDVF*RLSTAPRLYNQAKRRL*L*
AGSS*GDPNIYDLCCLSFSTRNILSHG*ICYAS
HINAKPFIPFPD*GTRA*GGCPRAVRWRFHPLG
S*HPS*VSAL***QFAGIEDCV*EG*AGK*KSSA
GCCLCEASRT*HNSLPGGSPLCFLCTCTGIIVA
TPCG*PTRCFRQRAARDFAANSCAAGSQKPDKS
L*RPSTG*HWIICY*GSHLL*R*TKDLFFGL*AG
IKRCDPLYLPSNHIPRTLSFN*KGDEMLYPRLF
CRAGLLVSSPQ*RIQRNGEQEEETAAQGSLWTS
GHEWKYSGQVYSSLTLT*ASEH*NC*ASGR*PEL
G*NAGRLSSQRRKNSAQKFRPFCSFKGCIKYFK
WPIRKQK*G**RERAYSE*CCVVNKGGLSESH*
SPETLCALQQLFCPVQQCS*CLCQSLDCNNGILW
KE*SYIRNIFREILFQAFLSVSKHVL*YPHGTS
YSALCSWPRLCADNPEGVGFSSTWISAYNSYIF
LV*NLQTGNTSCCSFQ*VLVYVICKIP*T*VLWA
PVYSQSQR*ALWSLHPS*LSPVFLL*PDGGVFQ
LFSHSAS*SMCSTPQNIH*ASGPIKSVPSSGSE
GLLSKSFTGICCH**KTCIFEN*YI**NKRGKNG
RYFCTERDGRR*VQELD*EDASKAHVFLCRYPS
ATAVGL*VTHCQETKSL*SAASLE*QVAGPFPT
GKG*KETFSSSKSWKTETRGRKQDKCDGCISTEY
FSRTSEWRKRGSLLNNFVQPELHQFYSSPIAYA
T*SHV*TVSGRAP*ARYSQQFRRCV*WAFAGIH
RQPSEGKVNHESHLCKFASRK*L*SYSISF*SR*
TLLNV*T*TSAHCSLREGTQLHHCFCSQL*RIP
KCLRGIV*SDSVEQCRRRASNK*YFR*QTKE*Q
PYQIT*NEWRTDKSYNRNRTTTNQKGFWNVVLLQ
RDSREKPRSLFPEERDLTWSR*CLLPGWADGQG
GDRESRR*ASR*SRWRRYTKEATHKSSCGTSIF
RC*CQVLLSALLCGRVS*DA*SDSGQQ*RRFHSF
PLPLITLAGPGRQIRSCLLCN*G**IYFEANAS
SGSPVLPRLCTTLLQLYYKCCSTKEAHGVGQNS
WSLQNWL*ELSEQH*EEVRSPCHGKSFLREKDGT
GF*FEGLS*ESECKN*HWKREL*CGPAR*KSPK
DGSRQPSIYSFSFQSCAENLDP**LPFPF*PPH
YRLFFAGWAR*Y*Q*ASSWNYRLYSNIYMGQKA*
DGCEINRNFRWTR*NANSGVSGVVQD*VL*GNG
QVFPNGTRPLDRLGSELLKSSTYFEMDCEGKGD
RNKGPKISYMFYFFIVFTTVCQGFSVLWLFRLSV
MEW*NSMNLHFGF*YLWSCL*VGKWHENFLKLK
YRHVSKG*SWR*VDRVKNGLNLLA*LF*EENSV
S*IDYPGITFNMLST*KAFVELLNLFCVFL**FN
VTYYQNF*NLYKNSDLFH*WPVKHVGIYCFIEE
FDLNWESCHVVYLSSLPVFEYV*CF*NFVFSVE
DRRLQQLTLSLLLEIFLKLV*NFCAIHILNCTYL
HTLIF*GFFSIFRVS**IISK*VCSY*TLME*L
LMKDF*NIKNKLGPIQEIE*EGNTCFIHRGKVS
FQYNQQFRWHL*NKKFLLWTSPFPTFYIMASSDY
*EMLRNRPSAVAHAYNPITLGGLGRQIT*GQEF
KTSLANMTKPHLY*KDKKLAGHGGIYL*PQLLG
WLRQENCLNLGGGGCSELGLHHCIPAWATEQDCL
KKQNETKKESYS**GTSCLIAFLFILKSDQK**
TIFEEIL*PQNISS*LLFVTRII*GFIKL*GFH
CFWTAYNNSTLTFT**EIWTSSVTQYDEYLN*EH
CGKFALENQGSSLVFGAY*KCGLF*TGSKLTKD
L*LM*C*VPLGPF*KRVCAF*RYTKH*GF*F*N
QRLLKELYRGKKINVEHY*LTLCLGTMDFVSDLK
CQHCFVSVHFFCEDT*GYYSCLFPVLP*S*ALE
VQGVSP*VQLGCFFVFSFNSMCIAGMLHRNGF*
Q*SVLLILFSLPMT*TTVF*STVV**VTLWQKFS
I*YILKQ*LLPCKGNLSF*NWTVLMKGKYTIYF
Y*VVELYVWSLAALV*ATIIDIFQILYYSVLSI
E*LFPFPSRPRVYSENLGMRKKS*YFLP*HTT*V
PRIIDSSKRKLCQ*HVALYKNLIYKCEAF*CHQ
NLLKNRIYFFLILT*EK**EQAVASSFVVY*IF
YRYSKFPTNYNFFHDLAVSDFLALALIRYCK**G
YIDISFCDGIVVISFMTFYPFAVILCKTAKESN
YL*EFAELEE*KLL*MSLIIKRTRPFIIPQVLI
Y*LMQYSNHLVQCFCFCFFFGNTGAVYYRKNKNY
NH*QF*YCCVSFVKNVHYVF*HVEF*TREMTL*
IIVASFNLI*KMPLY*KYLMYCIYFSTLVLAIL
YD*HVI*KITALNFWRLVL*IKKS*Q*TQNLLTP
Frame 2
TM*AASLPAATVRGLRSPPPLSGADFRGLSR*SGGWGGGQPARPGQEAQTHEMATDDKTSPTLDSA
NDLPRSPTSPSHLTHFKPLTPDQDEPPFKSAYS
SFVNLFRFNKERAEGGQGEQQPLSGSWTSPQLPS
RTQSVRSPTPYKKQLNEELQRRSSALDTRRKAE
PTFGGHDPRTAVQLRSLSTVLKRLKEIMEGKSQ
DSDLKQYWMPDSQCKECYDCSEKFTTFRRRHHCR
LCGQIFCSRCCNQEIPGKFMGYTGDLRACTYCR
KIALSYAHSTDSNSIGEDLNALSDSACSVSVLD
PSEPRTPVGSRKASRNIFLEDDLAWQSLIHPDSS
NTPLSTRLVSVQEDAGKSPARNRSASITNLSLD
RSGSPMVPSYETSVSPQANRTYVRTETTEDERK
ILLDSVQLKDLWKKICHHSSGMEFQDHRYWLRTH
PNCIVGKELVNWLIRNGHIATRAQAIAIGQAMV
DGRWLDCVSHHDQLFRDEYALYRPLQSTEFSET
PSPDSDSVNSVEGHSEPSWFKDIKFDDSDTEQIA
EEGDDNLANSASPSKRTSVSSFQSTVDSDSAAS
ISLNVELDNVNFHIKKPSKYPHVPPHPADQKEY
LISDTGGQQLSISDAFIKESLFNRRVEEKSKELP
FTPLGWHHNNLELLREENGEKQAMERLLSANHN
HMMALLQQLLHSDSLSSSWRDIIVSLVCQVVQT
VRPDVKNQDDDMDIRQFVHIKKIPGGKKFDSVVV
NGFVCTKNIAHKKMSSCIKNPKILLLKCSIEYL
YREETKFTCIDPIVLQEREFLKNYVQRIVDVRP
TLVLVEKTVSRIAQDMLLEHGITLVINVKSQVLE
RISRMTQGDLVMSMDQLLTKPHLGTCHKFYMQI
FQLPNEQTKTLMFFEGCPQHLGCTIKLRGGSDY
ELARVKEILIFMICVAYHSQLEISFLMDEFAMPP
TLMQNPSFHSLIEGRGHEGAVQEQYGGGSIPWD
PDIPPESLPCDDSSLLELRIVFEKGEQENKNLP
QAVASVKHQEHSTTACPAGLPCAFFAPVPESLLP
LPVDDQQDALGSEQPETLQQTVVLQDPKSQIRA
FRDPLQDDTGLYVTEEVTSSEDKRKTYSLAFKQ
ELKDVILCISPVITFREPFLLTEKGMRCSTRDYF
AEQVYWSPLLNKEFKEMENRRKKQLLRDLSGLQ
GMNGSIQAKSIQVLPSHELVSTRIAEHLGDSQS
LGRMLADYRARGGRIQPKNSDPFAHSKDASSTSS
GQSGSKNEGDEERGLILSDAVWSTKVDCLNPIN
HQRLCVLFSSSSAQSSNAPSACVSPWIVTMEFY
GKNDLTLGIFLERYCFRPSYQCPSMFCDTPMVHH
IRRFVHGQGCVQIILKELDSPVPGYQHTILTYS
WCRICKQVTPVVALSNESWSMSFAKYLELRFYG
HQYTRRANAEPCGHSIHHDYHQYFSYNQMVASFS
YSPIRLLEVCVPLPKIFIKRQAPLKVSLLQDLK
DFFQKVSQVYVAIDERLASLKTDTFSKTREEKM
EDIFAQKEMEEGEFKNWIEKMQARLMSSSVDTPQ
QLQSVFESLIAKKQSLCEVLQAWNNRLQDLFQQ
EKGRKRPSVPPSPGRLRQGEESKISAMDASPRN
ISPGLQNGEKEDRFLTTLSSQSSTSSTHLQLPTP
PEVMSEQSVGGPPELDTASSSEDVFDGHLLGST
DSQVKEKSTMKAIFANLLPGNSYNPIPFPFDPD
KHYLMYEHERVPIAVCEKEPSSIIAFALSCKEYR
NALEELSKATQWNSAEEGLPTNSTSDSRPKSSS
PIRLPEMSGGQTNRTTETEPQPTKKASGMLSFF
RGTAGKSPDLSSQKRETLRGADSAYYQVGQTGKE
GTENQGVEPQDEVDGGDTQKKQLINPHVELQFS
DANAKFYCRLYYAGEFHKMREVILDSSEEDFIR
SLSHSSPWQARGGKSGAAFYATEDDRFILKQMPR
LEVQSFLDFAPHYFNYITNAVQQKRPTALAKIL
GVYRIGYKNSQNNTEKKLDLLVMENLFYGRKMA
QVFDLKGSLRNRNVKTDTGKESCDVVLLDENLLK
MVRDNPLYIRSHSKAVLRTSIHSDSHFLSSHLI
IDYSLLVGRDDTSNELVVGIIDYIRTFTWDKKL
EMVVKSTGILGGQGKMPTVVSPELYRTRFCEAMD
KYFLMVPDHWTGLGLNC*NQAHILKWTVKEKGT
GTKDQK*ATCFISSSCSPLYAKAFQFCGCLDCP
*WNGKTP*ICTLVFDTCGAVCRLGSGMKIFLS*N
TDMFQRAKVGDE*IG*KMG*IC*LNCFKKKTVS
HKLTILASHLTCYLLRKHL*SC*ICFVFFCNNL
MLLIIRISETFTKILIYSINGRLNTWAFIVLLRN
LT*TGNPVMLFIFPACLFLSMFDVFKILSSLWK
TGGYSN*L*ASF*RYF*NLFKIFVQFIY*IALT
CIRSYSRVFSLFLGYHSKSLVNESVVTKP*WNNY
**KIFEI*KIN*AQSKKLSEKETLVLFTEVKCL
FNITSNLGGIYKIKNFYCGHPLFQLST*WLVLT
TKKC*EIGQVRWLTPIILSLWEA*AGRSPEVRSS
RPAWPT*RNPISTKKTKN*LGMVAYTCNPNYLG
G*GRRIV*TWEAEAAVSWDYTIAFQPGQQSKTV
SKNKTKQKKKVILSKELLV**HFCLF*KVIRSSK
LSLRKYCNPRIFPLDFFL*QG*FRDL*SCKDFT
VFGLPIIIAH*PSHNKKSGQVQLHSMMNT*IRN
IVENLL*RIKAVVWYLVLIKNVVCFELEAS*PRT
YD*CDAKFHLAPFKNVYVPFEDTQNTEDFSFEI
KDY*RSCTEVKK*MWNIINLLCV*EQWILYLI*
NANTVLSLFIFSVRILKVIIPVCFLYSPSHEHLK
YKVSPPRCN*VVSLFLVSILCA*QECSTGMASD
NNLSC*FCFPCP*LEQLCFKVL*SSR*LCGKNF
QYNTF*NNSCCLAKVISHFKIGQY**RGNIQFIS
IEW*NYMSGPLLLLFRPLS*IYFKYCTTQC*VL
NDCFPFLQGLEYILKI*E*GRNLNTSFLNIQHE
SRE*LIVARENYVSNMLLCIKILFINVKLFDAIK
TY*KIGFTFF*F*PKKNNENKLLQALL*SIEYF
IDIQNFLQTIIFSMI*Q*VIF*LWLLLGIVNSR
VISISAFVMALWSSAS*HFTHLQ*SCVKLPRKVI
TCRSLLSLKSENCCE*A*S*NGPGHSLFLKC*Y
TDLCSIQTI*CNVFVFVFFLVTQVQCIIEKIKT
TIISSFNTAVSVL*KMYIMSFDMLNFKLGK*HCK
S**PLLI*YEKCHYIEST*CIVYISLLWF*LFY
MIDMLFKR*LP*TFGDLYCK*RNLNNKLRIYLL
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