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Sequences

Sequence NM_207171

CGGCGTCTCTCTCCCCCGCGCCAGCTCCCGTACACGGAGCCGCATTCCTTGGCCCCCCCACCCCCCTCCCTCGGGGCCCCCCCGCCCCCCTCGGGAAAAA AATCCACCCCGAATCACTCGAACCCGAGGGAGGCTTCCTTTCACCCTTGGGGAGACGAGCTTTCAACGGTTACCTCTTCTTCGTCTCCCCCCAAGCCCCC GTCCCCTCCCCCTGCTCCCACCCCCTTCTGGCGCCGGGTGTAAGGTCCCTTTAAGGCGACGGCGCCTTCCTCGGGTCAGACTACCGGCGGCGACGACCAC AGGAGCATGGCGGACACCGACCTGTTCATGGAATGTGAGGAGGAGGAGTTGGAGCCATGGCAGAAAATCAGTGATGTCATTGAGGACTCTGTAGTTGAAG ATTATAATTCAGTGGATAAAACTACCACAGCTGGCAATCCTTTGGTCCAGCAAGGTGGACAGCCACTCATCCTGACCCAGAATCCAGCCCCAGGTCTGGG CACAATGGTTACTCAACCAGTATTGAGGCCTGTTCAGGTCATGCAGAATGCCAATCATGTGACTAGTTCCCCTGTGGCCTCACAACCAATATTTATCACT ACGCAGGGATTTCCTGTAAGGAATGTCCGGCCTGTACAAAATGCAATGAATCAGGTTGGGATTGTGCTGAACGTACAGCAAGGCCAAACGGTTAGACCAA TTACACTAGTTCCAGCCCCAGGTACCCAGTTTGTTAAGCCGACAGTTGGAGTTCCACAAGTGTTCTCCCAGATGACCCCTGTGAGGCCAGGCTCCACAAT GCCTGTGAGGCCCACCACCAACACCTTCACCACCGTCATCCCGGCCACTCTTACCATTCGAAGCACCGTCCCACAGTCCCAGTCCCAGCAGACCAAGTCC ACTCCCAGCACTTCTACCACTCCCACTGCCACACAGCCAACCTCACTGGGGCAACTAGCTGTTCAGTCTCCAGGCCAGTCAAACCAGACCACGAATCCCA AGCTAGCTCCCTCCTTCCCCTCTCCACCTGCAGTGAGCATTGCCAGCTTTGTCACTGTGAAGCGACCTGGTGTTACAGGCGAAAATAGCAATGAAGTGGC CAAATTGGTGAATACCCTTAACACCATCCCTTCCCTGGGCCAGAGTCCTGGGCCAGTGGTGGTGTCCAACAACAGCTCTGCTCATGGCTCTCAAAGAACC AGCGGACCTGAGTCTTCAATGAAAGTGACCTCTTCCATCCCAGTATTTGACCTCCAGGATGGTGGACGGAAAATATGTCCACGATGTAATGCTCAATTTC GTGTTACTGAAGCTTTGAGAGGTCACATGTGTTACTGTTGCCCAGAAATGGTTGAATACCAGAAGAAAGGAAAGTCCCTGGATTCAGAACCCAGTGTCCC ATCAGCAGCAAAGCCCCCATCCCCTGAGAAAACAGCTCCTGTTGCTTCCACACCCTCTTCTACACCTATTCCTGCTCTGTCACCGCCTACCAAAGTACCA GAACCAAATGAGAACGTGGGCGATGCCGTCCAGACCAAACTCATTATGCTTGTAGATGACTTCTACTATGGACGGGATGGTGGCAAAGTAGCCCAGCTCA CAAATTTCCCTAAGGTCGCCACATCTTTCCGATGCCCACATTGTACCAAAAGGCTAAAAAACAATATTCGATTCATGAACCATATGAAACACCACGTAGA ACTCGATCAGCAGAACGGTGAGGTAGATGGTCACACTATCTGCCAGCACTGTTACCGCCAGTTTTCCACTCCCTTCCAGCTTCAGTGCCACTTGGAAAAT GTTCATAGTCCCTATGAATCTACTACCAAGTGCAAGATCTGTGAATGGGCGTTTGAAAGTGAGCCACTATTTCTCCAGCATATGAAGGATACTCATAAGC CTGGAGAGATGCCTTATGTTTGCCAGGTGTGTCAATATCGCTCCTCACTCTACTCTGAGGTAGATGTCCATTTTCGGATGATCCATGAGGATACCCGGCA TCTGCTCTGCCCTTATTGCCTGAAGGTCTTCAAAAATGGCAATGCATTCCAACAGCATTACATGAGGCACCAGAAGAGAAATGTTTATCACTGCAACAAA TGCCGGCTGCAGTTTCTCTTTGCCAAGGACAAAATTGAACACAAGCTTCAACACCATAAAACCTTCCGTAAACCCAAGCAGCTGGAGGGCTTGAAACCAG GCACCAAGGTGACAATCCGGGCTTCCCGAGGGCAGCCACGAACTGTTCCTGTATCCTCTAATGATACACCTCCCAGCGCCTTGCAGGAGGCAGCACCGCT GACCTCCTCAATGGACCCTCTGCCTGTCTTCCTTTATCCCCCTGTCCAGCGCAGCATCCAGAAGAGAGCTGTTAGGAAAATGAGTGTCATGGGCCGGCAG ACATGCCTGGAGTGCAGCTTCGAGATCCCAGACTTCCCTAATCATTTCCCTACTTACGTACACTGCTCTCTGTGTCGCTATAGCACCTGCTGTTCTCGAG CTTATGCCAACCACATGATCAACAATCATGTTCCACGGAAGAGCCCCAAGTATTTGGCTTTGTTTAAAAATTCTGTGAGTGGAATCAAGCTGGCCTGCAC TTCATGTACCTTTGTTACCTCTGTGGGCGATGCTATGGCCAAGCATTTGGTATTCAACCCCTCTCACAGATCCAGCAGCATCCTGCCACGGGGACTCACT TGGATAGCTCACTCAAGGCATGGCCAGACTCGTGACCGAGTGCATGACCGGAACGTGAAGAATATGTACCCTCCTCCTTCCTTCCCCACTAACAAAGCTG CCACTGTGAAATCTGCGGGGGCCACCCCAGCTGAGCCTGAAGAGCTACTAACTCCCTTAGCCCCAGCACTCCCATCACCAGCCTCAACTGCAACCCCACC ACCAACCCCCACTCACCCGCAGGCTTTAGCCCTTCCACCGCTGGCTACAGAGGGAGCCGAATGTCTGAATGTTGATGATCAGGATGAAGGGAGCCCAGTC ACCCAAGAACCTGAGCTAGCATCAGGTGGTGGTGGTAGTGGTGGAGTTGGCAAAAAGGAGCAGCTGTCTGTGAAGAAGCTTCGAGTAGTACTGTTTGCTC TATGCTGCAATACAGAACAGGCAGCTGAACACTTCCGAAATCCCCAGCGACGTATTCGCCGTTGGCTTCGACGTTTCCAGGCCTCCCAGGGGGAGAATCT AGAGGGCAAATATCTGAGCTTTGAGGCAGAAGAGAAACTGGCTGAGTGGGTGCTAACCCAGCGCGAACAACAGCTACCTGTAAATGAGGAGACCTTGTTC CAGAAGGCCACCAAAATAGGACGTTCTTTGGAAGGGGGGTTTAAGATCTCCTATGAGTGGGCTGTGCGTTTCATGCTGCGGCACCACCTGACTCCCCATG CCCGGCGAGCTGTGGCCCACACCCTACCTAAGGATGTAGCAGAGAATGCAGGACTCTTCATTGATTTTGTACAACGGCAGATTCACAACCAGGACTTACC CTTGTCTATGATTGTGGCTATTGATGAGATCTCTTTGTTCCTGGATACAGAGGTGCTGAGCAGTGATGATCGAAAGGAGAATGCCCTGCAGACAGTGGGC ACAGGGGAACCTTGGTGTGATGTAGTCCTAGCCATTCTGGCAGATGGCACTGTCCTTCCCACCCTGGTTTTCTACAGAGGGCAGATGGATCAGCCTGCTA ACATGCCAGACTCCATATTGCTAGAGGCAAAGGAGAGTGGCTACAGTGATGACGAGATCATGGAGCTGTGGTCAACTCGAGTGTGGCAGAAGCACACAGC TTGCCAGCGCAGCAAAGGCATGCTTGTGATGGACTGTCATCGCACTCACTTGTCAGAAGAGGTACTGGCTATGCTTAGTGCCTCTAGCACTTTGCCTGCA GTGGTCCCAGCAGGCTGTAGCTCCAAAATTCAGCCATTAGATGTATGCATCAAAAGAACTGTCAAGAACTTCCTGCATAAAAAATGGAAGGAACAGGCTC GGGAAATGGCAGATACTGCATGTGATTCTGATGTCCTGCTTCAGCTGGTGCTTGTCTGGCTGGGTGAAGTGCTAGGTGTCATTGGGGACTGTCCAGAGCT AGTTCAGCGCTCCTTCCTGGTGGCTAGTGTTCTGCCTGGCCCCGATGGCAACATTAACTCACCTACAAGAAATGCTGACATGCAGGAGGAGCTAATTGCC TCCCTAGAGGAGCAACTGAAGCTGAGTGGGGAACATTCTGAGTCTTCCACTCCACGACCCAGATCATCTCCTGAAGAGACAATTGAGCCTGAAAGTCTTC ACCAGCTCTTTGAGGGTGAAAGTGAGACCGAGTCTTTCTATGGCTTTGAAGAAGCTGACCTAGATCTGATGGAGATTTGAGTGTTGGGGTCATGAGGGGG TGTGGAGTGAGGGTGGGAACATGTGAGGGAGGGTAAAGGGGCTTAGGGAAAAGGGGGCATACCAGGTGGGGTATTTGGTTTCTATTTTTTAATTTTATAC CACCACTCCCCCCTGAAGTTGACTTACACTTCCCTGTGGATTTGTGGATTAATTAGGAAAACCAATAGTAATCACGTCTGAGCCAAGGAGCTGGCCCATT GGTCATTCACTTCTGCTAAAAACAGGTTTTTGTGACTTTTTTTTTTTTTAAATTTAAATCACTGTGTTTGGTATTTTTCTGACAAAATTAAGAAAAAGAA AAAAAATTATTTGTGGGCAAATGTTAAATTTTTTTGTTTCCCCTTTTACCTCAATTGTATCATAGTACTGGGTTTTTTTGTTTGTTTTATTGTGTGGCCA ATGTCTTTGGGCATGATGCTATCTAATCATTGTTAATGTGAGAACATTTCTGAAGATGGGAAAGACAAATTATGTAGCTCACAAACTGGTTTATTATATA TATGGATAAAAAACTTTTTTCATTGTGGTCTTAACACTTTTATATAAAAATGAAAATGGAAAAAAAGTCCCACTGAACTCTCTCTTCCTTCTCCTTTTCT TTCCTTCCCTCTCCAGAGATGTTGGTTTCTACAGCAACCCTAGATATAAAATTGTGGCTTTAAAAATGCATGAAACCACCTTTAATTATCCAGAATGAAT AGATTTGTCTTTTCCTCACCACCTTCCCTCCAAAACATGACATAAACAATATTTTTTGCACTTGTGATCCTTGGCCCCTTTCCCCATTCTCAACACCATC CATCCCTCTGGACAAAGGATCATACAGGTGTTATTAGCAAGCAAGAGATACTGAAGCGATCAAACAGTTTTAGGGTGGAAGCCATTCCCAGTTTGAGTCT TCATCCTGTAAGCCCCCAGGGGCAGTCCCTGCTTTACTGAACTTCATCCTGTTAGATGGAGAGCATGCCTGTTTAAGGGATTACTGGTCCTACAGCCAGG AGCTAATTGTTCAAGAAGTGTTGAACTTTAAAAAGACAAGACCACTTGTTGAAATCCAGCGTGCTCTGTGGCTTTCCCCTATTTCTCTTAATACTTAGGG AAGAATCTGACAGGAAGAAGCGCACAGGGGTGTGCACAAAGAAAATGACATGAATCTTTATTTTTCACTGCCAGCTTCAAGGAAAGAAAATTTTTTCTAC AATTTGCATGAGGGATTTTTTTAATTGTATGTACTCATGGTTGTAAACCAAAACGTACTGTACCGTACAGAGAAAAGGAGCAAAAAACCAAGTCTTCTGT TTATCCTGAGGCTTTCCACAATGTTCCCCTCCTGTGAGCCAAGGAGGCAAACTGCACAAGCTTGTAAATGGTTCGTCTTTAAAATGTACATAAGTGGAAC ATTTAATAAAATGAGGGGAAATGGATTTATAAACTTGTTTTTTTTCTAGGTGACCCTGTTTAATAGGCTTTCACAGACTGGGGAATGCTCAAGATGTGAT GGGCCTGGTGGTACAGGTGTGACATTTGTTACCACCCATTTCTCCCACCCCACCCTGCTTTTTTGTTTGTTTGTTTTTTCATCCCCCAGCACACTATAAT ATAGTGAACTGGAAAAGTCCCTTCCAGAAACAGCTTGGCCAGCTTTGTGAACCTTTGACATCTGAAAACAACCAAGGATCCATCTGGGCTTCTCTTCCCC AGCTTTTTGCCTGATGCCATTTTATTGACAGACAATGGACTTTGAAGTCAGCCTTTGCCTTTGAGAAAGTTCAAGAACTATGGTTGGTCACGTCTATCTA CAACCTAATCCTACTCTTTGGTAGTCTCTGCAGCAGCCACAGCCTTAGCAGAGCTGGGGTTCCTGTCTTCTGCACACGATTGACTTTCTTGATGGGTAAT TTTTTTTAAGATTATACCAACAGTGGATCAGCTGGGTTTTGGCCAGGAAGTTGTCTTTGTGGACTCTGCCTGCATGGCTTAGTAGTAGAAGGAAATTTTT TTTTGGTTTTGTTTTTTATAATTCAGTTTAATCAATAAACATGTATTTATTGACTGTT

refseq_POGZ.F1 (forward primer)
refseq_POGZ.R1 (reverse primer)
Single exon skipping

Frame 0

RRLSPPRQLPYTEPHSLAPPPPSLGAPPPPSGK KSTPNHSNPREASFHPWGDELSTVTSSSSPPKPP SPPPAPTPFWRRV*GPFKATAPSSGQTTGGDDH RSMADTDLFMECEEEELEPWQKISDVIEDSVVE DYNSVDKTTTAGNPLVQQGGQPLILTQNPAPGLG TMVTQPVLRPVQVMQNANHVTSSPVASQPIFIT TQGFPVRNVRPVQNAMNQVGIVLNVQQGQTVRP ITLVPAPGTQFVKPTVGVPQVFSQMTPVRPGSTM PVRPTTNTFTTVIPATLTIRSTVPQSQSQQTKS TPSTSTTPTATQPTSLGQLAVQSPGQSNQTTNP KLAPSFPSPPAVSIASFVTVKRPGVTGENSNEVA KLVNTLNTIPSLGQSPGPVVVSNNSSAHGSQRT SGPESSMKVTSSIPVFDLQDGGRKICPRCNAQF RVTEALRGHMCYCCPEMVEYQKKGKSLDSEPSVP SAAKPPSPEKTAPVASTPSSTPIPALSPPTKVP EPNENVGDAVQTKLIMLVDDFYYGRDGGKVAQL TNFPKVATSFRCPHCTKRLKNNIRFMNHMKHHVE LDQQNGEVDGHTICQHCYRQFSTPFQLQCHLEN VHSPYESTTKCKICEWAFESEPLFLQHMKDTHK PGEMPYVCQVCQYRSSLYSEVDVHFRMIHEDTRH LLCPYCLKVFKNGNAFQQHYMRHQKRNVYHCNK CRLQFLFAKDKIEHKLQHHKTFRKPKQLEGLKP GTKVTIRASRGQPRTVPVSSNDTPPSALQEAAPL TSSMDPLPVFLYPPVQRSIQKRAVRKMSVMGRQ TCLECSFEIPDFPNHFPTYVHCSLCRYSTCCSR AYANHMINNHVPRKSPKYLALFKNSVSGIKLACT SCTFVTSVGDAMAKHLVFNPSHRSSSILPRGLT WIAHSRHGQTRDRVHDRNVKNMYPPPSFPTNKA ATVKSAGATPAEPEELLTPLAPALPSPASTATPP PTPTHPQALALPPLATEGAECLNVDDQDEGSPV TQEPELASGGGGSGGVGKKEQLSVKKLRVVLFA LCCNTEQAAEHFRNPQRRIRRWLRRFQASQGENL EGKYLSFEAEEKLAEWVLTQREQQLPVNEETLF QKATKIGRSLEGGFKISYEWAVRFMLRHHLTPH ARRAVAHTLPKDVAENAGLFIDFVQRQIHNQDLP LSMIVAIDEISLFLDTEVLSSDDRKENALQTVG TGEPWCDVVLAILADGTVLPTLVFYRGQMDQPA NMPDSILLEAKESGYSDDEIMELWSTRVWQKHTA CQRSKGMLVMDCHRTHLSEEVLAMLSASSTLPA VVPAGCSSKIQPLDVCIKRTVKNFLHKKWKEQA REMADTACDSDVLLQLVLVWLGEVLGVIGDCPEL VQRSFLVASVLPGPDGNINSPTRNADMQEELIA SLEEQLKLSGEHSESSTPRPRSSPEETIEPESL HQLFEGESETESFYGFEEADLDLMEI*VLGS*GG VE*GWEHVREGKGA*GKGGIPGGVFGFYFLILY HHSPLKLTYTSLWICGLIRKTNSNHV*AKELAH WSFTSAKNRFL*LFFFLNLNHCVWYFSDKIKKKK KNYLWANVKFFCFPFYLNCIIVLGFFVCFIVWP MSLGMMLSNHC*CENISEDGKDKLCSSQTGLLY IWIKNFFHCGLNTFI*K*KWKKSPTELSLPSPFL SFPLQRCWFLQQP*I*NCGFKNA*NHL*LSRMN RFVFSSPPSLQNMT*TIFFALVILGPFPHSQHH PSLWTKDHTGVISKQEILKRSNSFRVEAIPSLSL HPVSPQGQSLLY*TSSC*MESMPV*GITGPTAR S*LFKKC*TLKRQDHLLKSSVLCGFPLFLLILR EESDRKKRTGVCTKKMT*IFIFHCQLQGKKIFST ICMRDFFNCMYSWL*TKTYCTVQRKGAKNQVFC LS*GFPQCSPPVSQGGKLHKLVNGSSLKCT*VE HLIK*GEMDL*TCFFSR*PCLIGFHRLGNAQDVM GLVVQV*HLLPPISPTPPCFFVCLFFHPPAHYN IVNWKSPFQKQLGQLCEPLTSENNQGSIWASLP QLFA*CHFIDRQWTLKSAFAFEKVQELWLVTSIY NLILLFGSLCSSHSLSRAGVPVFCTRLTFLMGN FF*DYTNSGSAGFWPGSCLCGLCLHGLVVEGNF FLVLFFIIQFNQ*TCIY*L

Frame 1

GVSLPRASSRTRSRIPWPPHPPPSGPPRPPREK NPPRITRTRGRLPFTLGETSFQRLPLLRLPPSP RPLPLLPPPSGAGCKVPLRRRRLPRVRLPAATTT GAWRTPTCSWNVRRRSWSHGRKSVMSLRTL*LK IIIQWIKLPQLAILWSSKVDSHSS*PRIQPQVW AQWLLNQY*GLFRSCRMPIM*LVPLWPHNQYLSL RRDFL*GMSGLYKMQ*IRLGLC*TYSKAKRLDQ LH*FQPQVPSLLSRQLEFHKCSPR*PL*GQAPQ CL*GPPPTPSPPSSRPLLPFEAPSHSPSPSRPSP LPALLPLPLPHSQPHWGN*LFSLQASQTRPRIP S*LPPSPLHLQ*ALPALSL*SDLVLQAKIAMKW PNW*IPLTPSLPWARVLGQWWCPTTALLMALKEP ADLSLQ*K*PLPSQYLTSRMVDGKYVHDVMLNF VLLKL*EVTCVTVAQKWLNTRRKESPWIQNPVS HQQQSPHPLRKQLLLLPHPLLHLFLLCHRLPKYQ NQMRTWAMPSRPNSLCL*MTSTMDGMVAK*PSS QISLRSPHLSDAHIVPKG*KTIFDS*TI*NTT* NSISRTVR*MVTLSASTVTASFPLPSSFSATWKM FIVPMNLLPSARSVNGRLKVSHYFSSI*RILIS LERCLMFARCVNIAPHSTLR*MSIFG*SMRIPG ICSALIA*RSSKMAMHSNSIT*GTRREMFITATN AGCSFSLPRTKLNTSFNTIKPSVNPSSWRA*NQ APR*QSGLPEGSHELFLYPLMIHLPAPCRRQHR *PPQWTLCLSSFIPLSSAASRRELLGK*VSWAGR HAWSAASRSQTSLIISLLTYTALCVAIAPAVLE LMPTT*STIMFHGRAPSIWLCLKIL*VESSWPA LHVPLLPLWAMLWPSIWYSTPLTDPAASCHGDSL G*LTQGMARLVTECMTGT*RICTLLLPSPLTKL PL*NLRGPPQLSLKSY*LP*PQHSHHQPQLQPH HQPPLTRRL*PFHRWLQREPNV*MLMIRMKGAQS PKNLS*HQVVVVVVELAKRSSCL*RSFE*YCLL YAAIQNRQLNTSEIPSDVFAVGFDVSRPPRGRI *RANI*ALRQKRNWLSGC*PSANNSYL*MRRPCS RRPPK*DVLWKGGLRSPMSGLCVSCCGTT*LPM PGELWPTPYLRM*QRMQDSSLILYNGRFTTRTY PCL*LWLLMRSLCSWIQRC*AVMIERRMPCRQWA QGNLGVM*S*PFWQMALSFPPWFSTEGRWISLL TCQTPYC*RQRRVATVMTRSWSCGQLECGRSTQ LASAAKACL*WTVIALTCQKRYWLCLVPLALCLQ WSQQAVAPKFSH*MYASKELSRTSCIKNGRNRL GKWQILHVILMSCFSWCLSGWVKC*VSLGTVQS *FSAPSWWLVFCLAPMATLTHLQEMLTCRRS*LP P*RSN*S*VGNILSLPLHDPDHLLKRQLSLKVF TSSLRVKVRPSLSMALKKLT*I*WRFECWGHEG VWSEGGNM*GRVKGLREKGAYQVGYLVSIF*FYT TTPP*S*LTLPCGFVD*LGKPIVITSEPRSWPI GHSLLLKTGFCDFFFF*I*ITVFGIFLTKLRKR KKIICGQMLNFFVSPFTSIVS*YWVFLFVLLCGQ CLWA*CYLIIVNVRTFLKMGKTNYVAHKLVYYI YG*KTFFIVVLTLLYKNENGKKVPLNSLFLLLF FPSLSRDVGFYSNPRYKIVALKMHETTFNYPE*I DLSFPHHLPSKT*HKQYFLHL*SLAPFPILNTI HPSGQRIIQVLLASKRY*SDQTVLGWKPFPV*V FIL*APRGSPCFTELHPVRWRACLFKGLLVLQPG ANCSRSVEL*KDKTTC*NPACSVAFPYFS*YLG KNLTGRSAQGCAQRK*HESLFFTASFKERKFFL QFA*GIFLIVCTHGCKPKRTVPYREKEQKTKSSV YPEAFHNVPLL*AKEANCTSL*MVRL*NVHKWN I**NEGKWIYKLVFFLGDPV**AFTDWGMLKM* WAWWYRCDICYHPFLPPHPAFLFVCFFIPQHTII **TGKVPSRNSLASFVNL*HLKTTKDPSGLLFP SFLPDAILLTDNGL*SQPLPLRKFKNYGWSRLS TT*SYSLVVSAAATALAELGFLSSAHD*LS*WVI FFKIIPTVDQLGFGQEVVFVDSACMA***KEIF FWFCFL*FSLINKHVFIDC

Frame 2

ASLSPAPAPVHGAAFLGPPTPLPRGPPAPLGKK IHPESLEPEGGFLSPLGRRAFNGYLFFVSPQAP VPSPCSHPLLAPGVRSL*GDGAFLGSDYRRRRP QEHGGHRPVHGM*GGGVGAMAENQ*CH*GLCS*R L*FSG*NYHSWQSFGPARWTATHPDPESSPRSG HNGYSTSIEACSGHAECQSCD*FPCGLTTNIYH YAGISCKECPACTKCNESGWDCAERTARPNG*TN YTSSSPRYPVC*ADSWSSTSVLPDDPCEARLHN ACEAHHQHLHHRHPGHSYHSKHRPTVPVPADQV HSQHFYHSHCHTANLTGATSCSVSRPVKPDHESQ ASSLLPLSTCSEHCQLCHCEATWCYRRK*Q*SG QIGEYP*HHPFPGPESWASGGVQQQLCSWLSKN QRT*VFNESDLFHPSI*PPGWWTENMSTM*CSIS CY*SFERSHVLLLPRNG*IPEERKVPGFRTQCP ISSKAPIP*ENSSCCFHTLFYTYSCSVTAYQST RTK*ERGRCRPDQTHYACR*LLLWTGWWQSSPAH KFP*GRHIFPMPTLYQKAKKQYSIHEPYETPRR TRSAER*GRWSHYLPALLPPVFHSLPASVPLGK CS*SL*IYYQVQDL*MGV*K*ATISPAYEGYS*A WRDALCLPGVSISLLTLL*GRCPFSDDP*GYPA SALPLLPEGLQKWQCIPTALHEAPEEKCLSLQQ MPAAVSLCQGQN*TQASTP*NLP*TQAAGGLETR HQGDNPGFPRAATNCSCIL**YTSQRLAGGSTA DLLNGPSACLPLSPCPAQHPEESC*ENECHGPA DMPGVQLRDPRLP*SFPYLRTLLSVSL*HLLFSS LCQPHDQQSCSTEEPQVFGFV*KFCEWNQAGLH FMYLCYLCGRCYGQAFGIQPLSQIQQHPATGTH LDSSLKAWPDS*PSA*PEREEYVPSSFLPH*QSC HCEICGGHPS*A*RATNSLSPSTPITSLNCNPT TNPHSPAGFSPSTAGYRGSRMSEC**SG*REPS HPRT*ASIRWWW*WWSWQKGAAVCEEASSSTVCS MLQYRTGS*TLPKSPATYSPLASTFPGLPGGES RGQISEL*GRRETG*VGANPARTTATCK*GDLV PEGHQNRTFFGRGV*DLL*VGCAFHAAAPPDSPC PASCGPHPT*GCSRECRTLH*FCTTADSQPGLT LVYDCGY**DLFVPGYRGAEQ**SKGECPADSG HRGTLV*CSPSHSGRWHCPSHPGFLQRADGSAC* HARLHIARGKGEWLQ**RDHGAVVNSSVAEAHS LPAQQRHACDGLSSHSLVRRGTGYA*CL*HFAC SGPSRL*LQNSAIRCMHQKNCQELPA*KMEGTGS GNGRYCM*F*CPASAGACLAG*SARCHWGLSRA SSALLPGG*CSAWPRWQH*LTYKKC*HAGGANC LPRGATEAEWGTF*VFHSTTQIIS*RDN*A*KSS PAL*G*K*DRVFLWL*RS*PRSDGDLSVGVMRG CGVRVGTCEGG*RGLGKRGHTRWGIWFLFFNFI PPLPPEVDLHFPVDLWIN*ENQ**SRLSQGAGPL VIHFC*KQVFVTFFFFKFKSLCLVFF*QN*EKE KKLFVGKC*IFLFPLLPQLYHSTGFFCLFYCVA NVFGHDAI*SLLM*EHF*RWERQIM*LTNWFIIY MDKKLFSLWS*HFYIKMKMEKKSH*TLSSFSFS FLPSPEMLVSTATLDIKLWL*KCMKPPLIIQNE *ICLFLTTFPPKHDINNIFCTCDPWPLSPFSTPS IPLDKGSYRCY*QARDTEAIKQF*GGSHSQFES SSCKPPGAVPALLNFILLDGEHACLRDYWSYSQ ELIVQEVLNFKKTRPLVEIQRALWLSPISLNT*G RI*QEEAHRGVHKENDMNLYFSLPASRKENFFY NLHEGFF*LYVLMVVNQNVLYRTEKRSKKPSLL FILRLSTMFPSCEPRRQTAQACKWFVFKMYISGT FNKMRGNGFINLFFF*VTLFNRLSQTGECSRCD GPGGTGVTFVTTHFSHPTLLFCLFVFSSPSTL* YSELEKSLPETAWPAL*TFDI*KQPRIHLGFSSP AFCLMPFY*QTMDFEVSLCL*ESSRTMVGHVYL QPNPTLW*SLQQPQP*QSWGSCLLHTIDFLDG* FFLRLYQQWISWVLARKLSLWTLPAWLSSRRKFF FGFVFYNSV*SINMYLLTV

Sequence NM_145796

refseq_POGZ.F1 (forward primer)
refseq_POGZ.R1 (reverse primer)
Single exon skipping

Frame 0

Frame 1

Frame 2

Sequence NM_015100

CGGCGTCTCTCTCCCCCGCGCCAGCTCCCGTACACGGAGCCGCATTCCTTGGCCCCCCCACCCCCCTCCCTCGGGGCCCCCCCGCCCCCCTCGGGAAAAA AATCCACCCCGAATCACTCGAACCCGAGGGAGGCTTCCTTTCACCCTTGGGGAGACGAGCTTTCAACGGTTACCTCTTCTTCGTCTCCCCCCAAGCCCCC GTCCCCTCCCCCTGCTCCCACCCCCTTCTGGCGCCGGGTGTAAGGTCCCTTTAAGGCGACGGCGCCTTCCTCGGGTCAGACTACCGGCGGCGACGACCAC AGGAGCATGGCGGACACCGACCTGTTCATGGAATGTGAGGAGGAGGAGTTGGAGCCATGGCAGAAAATCAGTGATGTCATTGAGGACTCTGTAGTTGAAG ATTATAATTCAGTGGATAAAACTACCACAGTTTCTGTGAGCCAGCAGCCAGTCTCGGCTCCAGTGCCCATCGCTGCCCATGCTTCTGTTGCTGGGCACCT CTCTACATCCACCACCGTTAGTAGCAGCGGGGCACAGAACAGCGACAGTACAAAGAAGACTCTTGTCACACTAATTGCCAACAACAATGCTGGCAATCCT TTGGTCCAGCAAGGTGGACAGCCACTCATCCTGACCCAGAATCCAGCCCCAGGTCTGGGCACAATGGTTACTCAACCAGTATTGAGGCCTGTTCAGGTCA TGCAGAATGCCAATCATGTGACTAGTTCCCCTGTGGCCTCACAACCAATATTTATCACTACGCAGGGATTTCCTGTAAGGAATGTCCGGCCTGTACAAAA TGCAATGAATCAGGTTGGGATTGTGCTGAACGTACAGCAAGGCCAAACGGTTAGACCAATTACACTAGTTCCAGCCCCAGGTACCCAGTTTGTTAAGCCG ACAGTTGGAGTTCCACAAGTGTTCTCCCAGATGACCCCTGTGAGGCCAGGCTCCACAATGCCTGTGAGGCCCACCACCAACACCTTCACCACCGTCATCC CGGCCACTCTTACCATTCGAAGCACCGTCCCACAGTCCCAGTCCCAGCAGACCAAGTCCACTCCCAGCACTTCTACCACTCCCACTGCCACACAGCCAAC CTCACTGGGGCAACTAGCTGTTCAGTCTCCAGGCCAGTCAAACCAGACCACGAATCCCAAGCTAGCTCCCTCCTTCCCCTCTCCACCTGCAGTGAGCATT GCCAGCTTTGTCACTGTGAAGCGACCTGGTGTTACAGGCGAAAATAGCAATGAAGTGGCCAAATTGGTGAATACCCTTAACACCATCCCTTCCCTGGGCC AGAGTCCTGGGCCAGTGGTGGTGTCCAACAACAGCTCTGCTCATGGCTCTCAAAGAACCAGCGGACCTGAGTCTTCAATGAAAGTGACCTCTTCCATCCC AGTATTTGACCTCCAGGATGGTGGACGGAAAATATGTCCACGATGTAATGCTCAATTTCGTGTTACTGAAGCTTTGAGAGGTCACATGTGTTACTGTTGC CCAGAAATGGTTGAATACCAGAAGAAAGGAAAGTCCCTGGATTCAGAACCCAGTGTCCCATCAGCAGCAAAGCCCCCATCCCCTGAGAAAACAGCTCCTG TTGCTTCCACACCCTCTTCTACACCTATTCCTGCTCTGTCACCGCCTACCAAAGTACCAGAACCAAATGAGAACGTGGGCGATGCCGTCCAGACCAAACT CATTATGCTTGTAGATGACTTCTACTATGGACGGGATGGTGGCAAAGTAGCCCAGCTCACAAATTTCCCTAAGGTCGCCACATCTTTCCGATGCCCACAT TGTACCAAAAGGCTAAAAAACAATATTCGATTCATGAACCATATGAAACACCACGTAGAACTCGATCAGCAGAACGGTGAGGTAGATGGTCACACTATCT GCCAGCACTGTTACCGCCAGTTTTCCACTCCCTTCCAGCTTCAGTGCCACTTGGAAAATGTTCATAGTCCCTATGAATCTACTACCAAGTGCAAGATCTG TGAATGGGCGTTTGAAAGTGAGCCACTATTTCTCCAGCATATGAAGGATACTCATAAGCCTGGAGAGATGCCTTATGTTTGCCAGGTGTGTCAATATCGC TCCTCACTCTACTCTGAGGTAGATGTCCATTTTCGGATGATCCATGAGGATACCCGGCATCTGCTCTGCCCTTATTGCCTGAAGGTCTTCAAAAATGGCA ATGCATTCCAACAGCATTACATGAGGCACCAGAAGAGAAATGTTTATCACTGCAACAAATGCCGGCTGCAGTTTCTCTTTGCCAAGGACAAAATTGAACA CAAGCTTCAACACCATAAAACCTTCCGTAAACCCAAGCAGCTGGAGGGCTTGAAACCAGGCACCAAGGTGACAATCCGGGCTTCCCGAGGGCAGCCACGA ACTGTTCCTGTATCCTCTAATGATACACCTCCCAGCGCCTTGCAGGAGGCAGCACCGCTGACCTCCTCAATGGACCCTCTGCCTGTCTTCCTTTATCCCC CTGTCCAGCGCAGCATCCAGAAGAGAGCTGTTAGGAAAATGAGTGTCATGGGCCGGCAGACATGCCTGGAGTGCAGCTTCGAGATCCCAGACTTCCCTAA TCATTTCCCTACTTACGTACACTGCTCTCTGTGTCGCTATAGCACCTGCTGTTCTCGAGCTTATGCCAACCACATGATCAACAATCATGTTCCACGGAAG AGCCCCAAGTATTTGGCTTTGTTTAAAAATTCTGTGAGTGGAATCAAGCTGGCCTGCACTTCATGTACCTTTGTTACCTCTGTGGGCGATGCTATGGCCA AGCATTTGGTATTCAACCCCTCTCACAGATCCAGCAGCATCCTGCCACGGGGACTCACTTGGATAGCTCACTCAAGGCATGGCCAGACTCGTGACCGAGT GCATGACCGGAACGTGAAGAATATGTACCCTCCTCCTTCCTTCCCCACTAACAAAGCTGCCACTGTGAAATCTGCGGGGGCCACCCCAGCTGAGCCTGAA GAGCTACTAACTCCCTTAGCCCCAGCACTCCCATCACCAGCCTCAACTGCAACCCCACCACCAACCCCCACTCACCCGCAGGCTTTAGCCCTTCCACCGC TGGCTACAGAGGGAGCCGAATGTCTGAATGTTGATGATCAGGATGAAGGGAGCCCAGTCACCCAAGAACCTGAGCTAGCATCAGGTGGTGGTGGTAGTGG TGGAGTTGGCAAAAAGGAGCAGCTGTCTGTGAAGAAGCTTCGAGTAGTACTGTTTGCTCTATGCTGCAATACAGAACAGGCAGCTGAACACTTCCGAAAT CCCCAGCGACGTATTCGCCGTTGGCTTCGACGTTTCCAGGCCTCCCAGGGGGAGAATCTAGAGGGCAAATATCTGAGCTTTGAGGCAGAAGAGAAACTGG CTGAGTGGGTGCTAACCCAGCGCGAACAACAGCTACCTGTAAATGAGGAGACCTTGTTCCAGAAGGCCACCAAAATAGGACGTTCTTTGGAAGGGGGGTT TAAGATCTCCTATGAGTGGGCTGTGCGTTTCATGCTGCGGCACCACCTGACTCCCCATGCCCGGCGAGCTGTGGCCCACACCCTACCTAAGGATGTAGCA GAGAATGCAGGACTCTTCATTGATTTTGTACAACGGCAGATTCACAACCAGGACTTACCCTTGTCTATGATTGTGGCTATTGATGAGATCTCTTTGTTCC TGGATACAGAGGTGCTGAGCAGTGATGATCGAAAGGAGAATGCCCTGCAGACAGTGGGCACAGGGGAACCTTGGTGTGATGTAGTCCTAGCCATTCTGGC AGATGGCACTGTCCTTCCCACCCTGGTTTTCTACAGAGGGCAGATGGATCAGCCTGCTAACATGCCAGACTCCATATTGCTAGAGGCAAAGGAGAGTGGC TACAGTGATGACGAGATCATGGAGCTGTGGTCAACTCGAGTGTGGCAGAAGCACACAGCTTGCCAGCGCAGCAAAGGCATGCTTGTGATGGACTGTCATC GCACTCACTTGTCAGAAGAGGTACTGGCTATGCTTAGTGCCTCTAGCACTTTGCCTGCAGTGGTCCCAGCAGGCTGTAGCTCCAAAATTCAGCCATTAGA TGTATGCATCAAAAGAACTGTCAAGAACTTCCTGCATAAAAAATGGAAGGAACAGGCTCGGGAAATGGCAGATACTGCATGTGATTCTGATGTCCTGCTT CAGCTGGTGCTTGTCTGGCTGGGTGAAGTGCTAGGTGTCATTGGGGACTGTCCAGAGCTAGTTCAGCGCTCCTTCCTGGTGGCTAGTGTTCTGCCTGGCC CCGATGGCAACATTAACTCACCTACAAGAAATGCTGACATGCAGGAGGAGCTAATTGCCTCCCTAGAGGAGCAACTGAAGCTGAGTGGGGAACATTCTGA GTCTTCCACTCCACGACCCAGATCATCTCCTGAAGAGACAATTGAGCCTGAAAGTCTTCACCAGCTCTTTGAGGGTGAAAGTGAGACCGAGTCTTTCTAT GGCTTTGAAGAAGCTGACCTAGATCTGATGGAGATTTGAGTGTTGGGGTCATGAGGGGGTGTGGAGTGAGGGTGGGAACATGTGAGGGAGGGTAAAGGGG CTTAGGGAAAAGGGGGCATACCAGGTGGGGTATTTGGTTTCTATTTTTTAATTTTATACCACCACTCCCCCCTGAAGTTGACTTACACTTCCCTGTGGAT TTGTGGATTAATTAGGAAAACCAATAGTAATCACGTCTGAGCCAAGGAGCTGGCCCATTGGTCATTCACTTCTGCTAAAAACAGGTTTTTGTGACTTTTT TTTTTTTTAAATTTAAATCACTGTGTTTGGTATTTTTCTGACAAAATTAAGAAAAAGAAAAAAAATTATTTGTGGGCAAATGTTAAATTTTTTTGTTTCC CCTTTTACCTCAATTGTATCATAGTACTGGGTTTTTTTGTTTGTTTTATTGTGTGGCCAATGTCTTTGGGCATGATGCTATCTAATCATTGTTAATGTGA GAACATTTCTGAAGATGGGAAAGACAAATTATGTAGCTCACAAACTGGTTTATTATATATATGGATAAAAAACTTTTTTCATTGTGGTCTTAACACTTTT ATATAAAAATGAAAATGGAAAAAAAGTCCCACTGAACTCTCTCTTCCTTCTCCTTTTCTTTCCTTCCCTCTCCAGAGATGTTGGTTTCTACAGCAACCCT AGATATAAAATTGTGGCTTTAAAAATGCATGAAACCACCTTTAATTATCCAGAATGAATAGATTTGTCTTTTCCTCACCACCTTCCCTCCAAAACATGAC ATAAACAATATTTTTTGCACTTGTGATCCTTGGCCCCTTTCCCCATTCTCAACACCATCCATCCCTCTGGACAAAGGATCATACAGGTGTTATTAGCAAG CAAGAGATACTGAAGCGATCAAACAGTTTTAGGGTGGAAGCCATTCCCAGTTTGAGTCTTCATCCTGTAAGCCCCCAGGGGCAGTCCCTGCTTTACTGAA CTTCATCCTGTTAGATGGAGAGCATGCCTGTTTAAGGGATTACTGGTCCTACAGCCAGGAGCTAATTGTTCAAGAAGTGTTGAACTTTAAAAAGACAAGA CCACTTGTTGAAATCCAGCGTGCTCTGTGGCTTTCCCCTATTTCTCTTAATACTTAGGGAAGAATCTGACAGGAAGAAGCGCACAGGGGTGTGCACAAAG AAAATGACATGAATCTTTATTTTTCACTGCCAGCTTCAAGGAAAGAAAATTTTTTCTACAATTTGCATGAGGGATTTTTTTAATTGTATGTACTCATGGT TGTAAACCAAAACGTACTGTACCGTACAGAGAAAAGGAGCAAAAAACCAAGTCTTCTGTTTATCCTGAGGCTTTCCACAATGTTCCCCTCCTGTGAGCCA AGGAGGCAAACTGCACAAGCTTGTAAATGGTTCGTCTTTAAAATGTACATAAGTGGAACATTTAATAAAATGAGGGGAAATGGATTTATAAACTTGTTTT TTTTCTAGGTGACCCTGTTTAATAGGCTTTCACAGACTGGGGAATGCTCAAGATGTGATGGGCCTGGTGGTACAGGTGTGACATTTGTTACCACCCATTT CTCCCACCCCACCCTGCTTTTTTGTTTGTTTGTTTTTTCATCCCCCAGCACACTATAATATAGTGAACTGGAAAAGTCCCTTCCAGAAACAGCTTGGCCA GCTTTGTGAACCTTTGACATCTGAAAACAACCAAGGATCCATCTGGGCTTCTCTTCCCCAGCTTTTTGCCTGATGCCATTTTATTGACAGACAATGGACT TTGAAGTCAGCCTTTGCCTTTGAGAAAGTTCAAGAACTATGGTTGGTCACGTCTATCTACAACCTAATCCTACTCTTTGGTAGTCTCTGCAGCAGCCACA GCCTTAGCAGAGCTGGGGTTCCTGTCTTCTGCACACGATTGACTTTCTTGATGGGTAATTTTTTTTAAGATTATACCAACAGTGGATCAGCTGGGTTTTG GCCAGGAAGTTGTCTTTGTGGACTCTGCCTGCATGGCTTAGTAGTAGAAGGAAATTTTTTTTTGGTTTTGTTTTTTATAATTCAGTTTAATCAATAAACA TGTATTTATTGACTGTT

refseq_POGZ.F1 (forward primer)
refseq_POGZ.R1 (reverse primer)
Single exon skipping

Frame 0

RRLSPPRQLPYTEPHSLAPPPPSLGAPPPPSGK KSTPNHSNPREASFHPWGDELSTVTSSSSPPKPP SPPPAPTPFWRRV*GPFKATAPSSGQTTGGDDH RSMADTDLFMECEEEELEPWQKISDVIEDSVVE DYNSVDKTTTVSVSQQPVSAPVPIAAHASVAGHL STSTTVSSSGAQNSDSTKKTLVTLIANNNAGNP LVQQGGQPLILTQNPAPGLGTMVTQPVLRPVQV MQNANHVTSSPVASQPIFITTQGFPVRNVRPVQN AMNQVGIVLNVQQGQTVRPITLVPAPGTQFVKP TVGVPQVFSQMTPVRPGSTMPVRPTTNTFTTVI PATLTIRSTVPQSQSQQTKSTPSTSTTPTATQPT SLGQLAVQSPGQSNQTTNPKLAPSFPSPPAVSI ASFVTVKRPGVTGENSNEVAKLVNTLNTIPSLG QSPGPVVVSNNSSAHGSQRTSGPESSMKVTSSIP VFDLQDGGRKICPRCNAQFRVTEALRGHMCYCC PEMVEYQKKGKSLDSEPSVPSAAKPPSPEKTAP VASTPSSTPIPALSPPTKVPEPNENVGDAVQTKL IMLVDDFYYGRDGGKVAQLTNFPKVATSFRCPH CTKRLKNNIRFMNHMKHHVELDQQNGEVDGHTI CQHCYRQFSTPFQLQCHLENVHSPYESTTKCKIC EWAFESEPLFLQHMKDTHKPGEMPYVCQVCQYR SSLYSEVDVHFRMIHEDTRHLLCPYCLKVFKNG NAFQQHYMRHQKRNVYHCNKCRLQFLFAKDKIEH KLQHHKTFRKPKQLEGLKPGTKVTIRASRGQPR TVPVSSNDTPPSALQEAAPLTSSMDPLPVFLYP PVQRSIQKRAVRKMSVMGRQTCLECSFEIPDFPN HFPTYVHCSLCRYSTCCSRAYANHMINNHVPRK SPKYLALFKNSVSGIKLACTSCTFVTSVGDAMA KHLVFNPSHRSSSILPRGLTWIAHSRHGQTRDRV HDRNVKNMYPPPSFPTNKAATVKSAGATPAEPE ELLTPLAPALPSPASTATPPPTPTHPQALALPP LATEGAECLNVDDQDEGSPVTQEPELASGGGGSG GVGKKEQLSVKKLRVVLFALCCNTEQAAEHFRN PQRRIRRWLRRFQASQGENLEGKYLSFEAEEKL AEWVLTQREQQLPVNEETLFQKATKIGRSLEGGF KISYEWAVRFMLRHHLTPHARRAVAHTLPKDVA ENAGLFIDFVQRQIHNQDLPLSMIVAIDEISLF LDTEVLSSDDRKENALQTVGTGEPWCDVVLAILA DGTVLPTLVFYRGQMDQPANMPDSILLEAKESG YSDDEIMELWSTRVWQKHTACQRSKGMLVMDCH RTHLSEEVLAMLSASSTLPAVVPAGCSSKIQPLD VCIKRTVKNFLHKKWKEQAREMADTACDSDVLL QLVLVWLGEVLGVIGDCPELVQRSFLVASVLPG PDGNINSPTRNADMQEELIASLEEQLKLSGEHSE SSTPRPRSSPEETIEPESLHQLFEGESETESFY GFEEADLDLMEI*VLGS*GGVE*GWEHVREGKG A*GKGGIPGGVFGFYFLILYHHSPLKLTYTSLWI CGLIRKTNSNHV*AKELAHWSFTSAKNRFL*LF FFLNLNHCVWYFSDKIKKKKKNYLWANVKFFCF PFYLNCIIVLGFFVCFIVWPMSLGMMLSNHC*CE NISEDGKDKLCSSQTGLLYIWIKNFFHCGLNTF I*K*KWKKSPTELSLPSPFLSFPLQRCWFLQQP *I*NCGFKNA*NHL*LSRMNRFVFSSPPSLQNMT *TIFFALVILGPFPHSQHHPSLWTKDHTGVISK QEILKRSNSFRVEAIPSLSLHPVSPQGQSLLY* TSSC*MESMPV*GITGPTARS*LFKKC*TLKRQD HLLKSSVLCGFPLFLLILREESDRKKRTGVCTK KMT*IFIFHCQLQGKKIFSTICMRDFFNCMYSW L*TKTYCTVQRKGAKNQVFCLS*GFPQCSPPVSQ GGKLHKLVNGSSLKCT*VEHLIK*GEMDL*TCF FSR*PCLIGFHRLGNAQDVMGLVVQV*HLLPPI SPTPPCFFVCLFFHPPAHYNIVNWKSPFQKQLGQ LCEPLTSENNQGSIWASLPQLFA*CHFIDRQWT LKSAFAFEKVQELWLVTSIYNLILLFGSLCSSH SLSRAGVPVFCTRLTFLMGNFF*DYTNSGSAGFW PGSCLCGLCLHGLVVEGNFFLVLFFIIQFNQ*T CIY*L

Frame 1

GVSLPRASSRTRSRIPWPPHPPPSGPPRPPREK NPPRITRTRGRLPFTLGETSFQRLPLLRLPPSP RPLPLLPPPSGAGCKVPLRRRRLPRVRLPAATTT GAWRTPTCSWNVRRRSWSHGRKSVMSLRTL*LK IIIQWIKLPQFL*ASSQSRLQCPSLPMLLLLGT SLHPPPLVAAGHRTATVQRRLLSH*LPTTMLAIL WSSKVDSHSS*PRIQPQVWAQWLLNQY*GLFRS CRMPIM*LVPLWPHNQYLSLRRDFL*GMSGLYK MQ*IRLGLC*TYSKAKRLDQLH*FQPQVPSLLSR QLEFHKCSPR*PL*GQAPQCL*GPPPTPSPPSS RPLLPFEAPSHSPSPSRPSPLPALLPLPLPHSQ PHWGN*LFSLQASQTRPRIPS*LPPSPLHLQ*AL PALSL*SDLVLQAKIAMKWPNW*IPLTPSLPWA RVLGQWWCPTTALLMALKEPADLSLQ*K*PLPS QYLTSRMVDGKYVHDVMLNFVLLKL*EVTCVTVA QKWLNTRRKESPWIQNPVSHQQQSPHPLRKQLL LLPHPLLHLFLLCHRLPKYQNQMRTWAMPSRPN SLCL*MTSTMDGMVAK*PSSQISLRSPHLSDAHI VPKG*KTIFDS*TI*NTT*NSISRTVR*MVTLS ASTVTASFPLPSSFSATWKMFIVPMNLLPSARS VNGRLKVSHYFSSI*RILISLERCLMFARCVNIA PHSTLR*MSIFG*SMRIPGICSALIA*RSSKMA MHSNSIT*GTRREMFITATNAGCSFSLPRTKLN TSFNTIKPSVNPSSWRA*NQAPR*QSGLPEGSHE LFLYPLMIHLPAPCRRQHR*PPQWTLCLSSFIP LSSAASRRELLGK*VSWAGRHAWSAASRSQTSL IISLLTYTALCVAIAPAVLELMPTT*STIMFHGR APSIWLCLKIL*VESSWPALHVPLLPLWAMLWP SIWYSTPLTDPAASCHGDSLG*LTQGMARLVTE CMTGT*RICTLLLPSPLTKLPL*NLRGPPQLSLK SY*LP*PQHSHHQPQLQPHHQPPLTRRL*PFHR WLQREPNV*MLMIRMKGAQSPKNLS*HQVVVVV VELAKRSSCL*RSFE*YCLLYAAIQNRQLNTSEI PSDVFAVGFDVSRPPRGRI*RANI*ALRQKRNW LSGC*PSANNSYL*MRRPCSRRPPK*DVLWKGG LRSPMSGLCVSCCGTT*LPMPGELWPTPYLRM*Q RMQDSSLILYNGRFTTRTYPCL*LWLLMRSLCS WIQRC*AVMIERRMPCRQWAQGNLGVM*S*PFW QMALSFPPWFSTEGRWISLLTCQTPYC*RQRRVA TVMTRSWSCGQLECGRSTQLASAAKACL*WTVI ALTCQKRYWLCLVPLALCLQWSQQAVAPKFSH* MYASKELSRTSCIKNGRNRLGKWQILHVILMSCF SWCLSGWVKC*VSLGTVQS*FSAPSWWLVFCLA PMATLTHLQEMLTCRRS*LPP*RSN*S*VGNIL SLPLHDPDHLLKRQLSLKVFTSSLRVKVRPSLSM ALKKLT*I*WRFECWGHEGVWSEGGNM*GRVKG LREKGAYQVGYLVSIF*FYTTTPP*S*LTLPCG FVD*LGKPIVITSEPRSWPIGHSLLLKTGFCDFF FF*I*ITVFGIFLTKLRKRKKIICGQMLNFFVS PFTSIVS*YWVFLFVLLCGQCLWA*CYLIIVNV RTFLKMGKTNYVAHKLVYYIYG*KTFFIVVLTLL YKNENGKKVPLNSLFLLLFFPSLSRDVGFYSNP RYKIVALKMHETTFNYPE*IDLSFPHHLPSKT* HKQYFLHL*SLAPFPILNTIHPSGQRIIQVLLAS KRY*SDQTVLGWKPFPV*VFIL*APRGSPCFTE LHPVRWRACLFKGLLVLQPGANCSRSVEL*KDK TTC*NPACSVAFPYFS*YLGKNLTGRSAQGCAQR K*HESLFFTASFKERKFFLQFA*GIFLIVCTHG CKPKRTVPYREKEQKTKSSVYPEAFHNVPLL*A KEANCTSL*MVRL*NVHKWNI**NEGKWIYKLVF FLGDPV**AFTDWGMLKM*WAWWYRCDICYHPF LPPHPAFLFVCFFIPQHTII**TGKVPSRNSLA SFVNL*HLKTTKDPSGLLFPSFLPDAILLTDNGL *SQPLPLRKFKNYGWSRLSTT*SYSLVVSAAAT ALAELGFLSSAHD*LS*WVIFFKIIPTVDQLGF GQEVVFVDSACMA***KEIFFWFCFL*FSLINKH VFIDC

Frame 2

ASLSPAPAPVHGAAFLGPPTPLPRGPPAPLGKK IHPESLEPEGGFLSPLGRRAFNGYLFFVSPQAP VPSPCSHPLLAPGVRSL*GDGAFLGSDYRRRRP QEHGGHRPVHGM*GGGVGAMAENQ*CH*GLCS*R L*FSG*NYHSFCEPAASLGSSAHRCPCFCCWAP LYIHHR**QRGTEQRQYKEDSCHTNCQQQCWQS FGPARWTATHPDPESSPRSGHNGYSTSIEACSGH AECQSCD*FPCGLTTNIYHYAGISCKECPACTK CNESGWDCAERTARPNG*TNYTSSSPRYPVC*A DSWSSTSVLPDDPCEARLHNACEAHHQHLHHRHP GHSYHSKHRPTVPVPADQVHSQHFYHSHCHTAN LTGATSCSVSRPVKPDHESQASSLLPLSTCSEH CQLCHCEATWCYRRK*Q*SGQIGEYP*HHPFPGP ESWASGGVQQQLCSWLSKNQRT*VFNESDLFHP SI*PPGWWTENMSTM*CSISCY*SFERSHVLLL PRNG*IPEERKVPGFRTQCPISSKAPIP*ENSSC CFHTLFYTYSCSVTAYQSTRTK*ERGRCRPDQT HYACR*LLLWTGWWQSSPAHKFP*GRHIFPMPT LYQKAKKQYSIHEPYETPRRTRSAER*GRWSHYL PALLPPVFHSLPASVPLGKCS*SL*IYYQVQDL *MGV*K*ATISPAYEGYS*AWRDALCLPGVSIS LLTLL*GRCPFSDDP*GYPASALPLLPEGLQKWQ CIPTALHEAPEEKCLSLQQMPAAVSLCQGQN*T QASTP*NLP*TQAAGGLETRHQGDNPGFPRAAT NCSCIL**YTSQRLAGGSTADLLNGPSACLPLSP CPAQHPEESC*ENECHGPADMPGVQLRDPRLP* SFPYLRTLLSVSL*HLLFSSLCQPHDQQSCSTE EPQVFGFV*KFCEWNQAGLHFMYLCYLCGRCYGQ AFGIQPLSQIQQHPATGTHLDSSLKAWPDS*PS A*PEREEYVPSSFLPH*QSCHCEICGGHPS*A* RATNSLSPSTPITSLNCNPTTNPHSPAGFSPSTA GYRGSRMSEC**SG*REPSHPRT*ASIRWWW*W WSWQKGAAVCEEASSSTVCSMLQYRTGS*TLPK SPATYSPLASTFPGLPGGESRGQISEL*GRRETG *VGANPARTTATCK*GDLVPEGHQNRTFFGRGV *DLL*VGCAFHAAAPPDSPCPASCGPHPT*GCS RECRTLH*FCTTADSQPGLTLVYDCGY**DLFVP GYRGAEQ**SKGECPADSGHRGTLV*CSPSHSG RWHCPSHPGFLQRADGSAC*HARLHIARGKGEW LQ**RDHGAVVNSSVAEAHSLPAQQRHACDGLSS HSLVRRGTGYA*CL*HFACSGPSRL*LQNSAIR CMHQKNCQELPA*KMEGTGSGNGRYCM*F*CPA SAGACLAG*SARCHWGLSRASSALLPGG*CSAWP RWQH*LTYKKC*HAGGANCLPRGATEAEWGTF* VFHSTTQIIS*RDN*A*KSSPAL*G*K*DRVFL WL*RS*PRSDGDLSVGVMRGCGVRVGTCEGG*RG LGKRGHTRWGIWFLFFNFIPPLPPEVDLHFPVD LWIN*ENQ**SRLSQGAGPLVIHFC*KQVFVTF FFFKFKSLCLVFF*QN*EKEKKLFVGKC*IFLFP LLPQLYHSTGFFCLFYCVANVFGHDAI*SLLM* EHF*RWERQIM*LTNWFIIYMDKKLFSLWS*HF YIKMKMEKKSH*TLSSFSFSFLPSPEMLVSTATL DIKLWL*KCMKPPLIIQNE*ICLFLTTFPPKHD INNIFCTCDPWPLSPFSTPSIPLDKGSYRCY*Q ARDTEAIKQF*GGSHSQFESSSCKPPGAVPALLN FILLDGEHACLRDYWSYSQELIVQEVLNFKKTR PLVEIQRALWLSPISLNT*GRI*QEEAHRGVHK ENDMNLYFSLPASRKENFFYNLHEGFF*LYVLMV VNQNVLYRTEKRSKKPSLLFILRLSTMFPSCEP RRQTAQACKWFVFKMYISGTFNKMRGNGFINLF FF*VTLFNRLSQTGECSRCDGPGGTGVTFVTTHF SHPTLLFCLFVFSSPSTL*YSELEKSLPETAWP AL*TFDI*KQPRIHLGFSSPAFCLMPFY*QTMD FEVSLCL*ESSRTMVGHVYLQPNPTLW*SLQQPQ P*QSWGSCLLHTIDFLDG*FFLRLYQQWISWVL ARKLSLWTLPAWLSSRRKFFFGFVFYNSV*SIN MYLLTV