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Sequences

Sequence NM_181492

GGGCCTCTGATTCATCTTTATTCCCTCCATCATCTAGACTTGATTTTATTTGTACCAAGGAGATGCGTGTCTAATGTTTTTCTTTCTTCTATTTCTAGGA GGGCTGTTGGCCTGCTGCTGTGCTGCTGAACAGTATGCAGTCCTTTCGGGAGCAAAGCAGTTACCACGGAAACCAGCAAAGCTACCCACAGGAGGTACAC GGCTCATCCCGGCTAGAAGAGTTCAGCCCTCGTCAGGCCCAGATGTTCCAGAATTTTGGAGGTACAGGTGGCAGTAGTGGCAGCAGTGGCAGTGGCAGTG GTGGTGGACGACGAGGAGCAGCAGCTGCTGCGGCAGCGATGGCTAGCGAGACCTCTGGCCATCAAGGTTACCAGGGTTTCAGGAAAGAGGCTGGAGATTT TTACTACATGGCAGGCAACAAAGACCCCGTGACTACAGGAACCCCACAGCCTCCTCAGCGAAGGCCTTCTGGGCCTGTGCAGAGCTATGGACCCCCCCAG GGGAGCAGCTTTGGCAATCAGTATGGGAGTGAGGGTCATGTGGGCCAGTTTCAAGCACAGCACTCTGGCCTTGGCGGTGTGTCACATTATCAGCAGGATT ACACTGGGCCTTTCTCTCCAGGGAGTGCTCAGTACCAACAGCAGGCTTCCAGCCAGCAGCAGCAGCAGCAAGTCCAGCAGTTGAGACAACAGCTTTACCA GTCCCATCAGCCCCTGCCACAGGCCACTGGCCAACCAGCATCCAGCTCATCCCATCTACAGCCAATGCAGCGGCCCTCAACTCTGCCATCCTCTGCTGCT GGTTACCAGTTAAGAGTGGGTCAGTTTGGCCAACACTATCAGTCTTCTGCTTCCTCCTCCTCCTCCTCCTCCTTCCCTTCACCACAGCGTTTTAGCCAGT CTGGACAGAGCTATGATGGCAGTTACAATGTGAATGCTGGATCTCAGTATGAAGGACACAATGTGGGTTCTAATGCACAGGCTTATGGAACACAATCCAA TTACAGCTATCAGCCTCAATCTATGAAGAATTTTGAACAGGCAAAGATTCCACAAGGGACCCAACAGGGGCAGCAGCAGCAGCAACCGCAGCAACAACAA CACCCTTCTCAGCATGTGATGCAGTATACTAACGCTGCCACCAAGCTGCCCCTGCAAAGCCAAGTGGGGCAGTACAACCAGCCTGAGGTTCCTGTGAGGT CCCCCATGCAGTTTCACCAGAACTTCAGCCCCATTTCTAACCCTTCTCCAGCTGCCTCTGTGGTTCAGTCTCCAAGCTGTAGTTCTACCCCATCTCCTCT CATGCAGACTGGGGAGAATCTCCAGTGTGGGCAAGGCAGTGTGCCTATGGGTTCCAGAAACAGAATTTTACAGTTAATGCCTCAACTCAGTCCAACCCCA TCAATGATGCCCAGTCCTAATTCTCATGCTGCAGGCTTCAAAGGGTTTGGACTAGAAGGGGTACCAGAAAAGCGACTGACAGATCCTGGGTTGAGTAGTT TGAGTGCTCTGAGTACTCAAGTGGCCAATCTTCCTAACACTGTCCAGCACATGTTACTTTCTGATGCCCTGACTCCTCAGAAGAAGACCTCCAAGAGGCC CTCATCTTCCAAGAAAGCAGATAGCTGCACAAATTCTGAAGGCTCCTCACAACCTGAAGAACAGCTGAAGTCCCCTATGGCAGAGTCATTAGATGGAGGC TGCTCCAGCAGTTCAGAGGATCAAGGCGAGAGAGTGCGGCAACTAAGTGGCCAGAGCACCAGCTCTGACACCACCTACAAGGGTGGAGCCTCTGAGAAAG CTGGCTCCTCACCGGCACAAGGTGCTCAGAATGAACCCCCCAGACTCAATGCTAGTCCTGCCGCAAGAGAAGAGGCCACCTCACCAGGCGCTAAGGACAT GCCATTGTCATCCGACGGGAACCCAAAGGTTAATGAGAAGACTGTTGGGGTGATTGTCTCCCGGGAAGCCATGACAGGTCGGGTAGAAAAGCCTGGTGGA CAAGATAAAGGCTCCCAAGAGGATGATCCTGCAGCCACTCAAAGGCCACCTAGCAATGGTGGGGCAAAGGAAACCAGTCATGCATCACTTCCCCAGCCAG AGCCTCCAGGAGGAGGAGGGAGCAAAGGAAACAAGAATGGCGATAACAACTCCAACCATAATGGAGAAGGAAATGGCCAGAGTGGCCACTCTGCAGCGGG CCCTGGTTTTACGAGCAGAACTGAGCCTAGCAAATCTCCTGGAAGTCTGCGCTATAGTTACAAAGATAGTTTCGGGTCAGCCGTGCCACGAAATGTCAGT GGCTTTCCTCAGTATCCTACAGGGCAAGAAAAGGGAGATTTCACTGGCCATGGGGAACGAAAGGGTAGAAATGAAAAATTCCCAAGCCTCCTGCAGGAAG TGCTTCAGGGTTACCACCACCACCCTGACAGGAGATATTCTAGGAGTACTCAAGAGCATCAGGGGATGGCTGGTAGCCTAGAAGGAACCACAAGGCCCAA TGTCTTGGTTAGTCAAACCAATGAATTAGCTAGCAGGGGCCTTCTGAACAAAAGCATTGGGTCTCTATTAGAAAATCCCCACTGGGGCCCCTGGGAAAGG AAATCAAGCAGCACAGCTCCTGAAATGAAACAGATCAATTTGACTGACTATCCAATTCCCAGAAAGTTTGAAATAGAGCCTCAGTCATCAGCACATGAGC CTGGGGGTTCCCTCTCTGAAAGAAGATCAGTGATCTGTGATATTTCTCCACTAAGACAGATTGTCAGGGACCCAGGGGCTCACTCACTGGGACACATGAG TGCCGACACCAGAATTGGGAGGAATGACCGTCTCAATCCAACTTTAAGTCAGTCGGTCATTCTTCCTGGTGGTTTGGTGTCCATGGAAACCAAGCTGAAA TCCCAGAGCGGGCAGATAAAAGAGGAAGACTTTGAACAGTCTAAATCTCAAGCTAGTTTCAACAACAAGAAATCTGGAGACCACTGCCATCCTCCTAGCA TCAAGCATGAGTCTTACCGCGGCAATGCCAGCCCTGGAGCAGCAACCCATGATTCCCTTTCAGACTATGGCCCGCAAGACAGCAGACCCACGCCAATGCG GCGGGTCCCTGGCAGAGTTGGTGGTCGGGAGGGCATGAGGGGTCGGTCCCCTTCTCAATATCATGACTTTGCAGAAAAATTGAAAATGTCTCCTGGGCGG AGCAGAGGCCCAGGGGGAGACCCTCATCACATGAATCCACACATGACCTTTTCAGAGAGGGCTAACCGGAGTTCTTTACACACTCCCTTTTCTCCCAACT CAGAAACCCTGGCCTCTGCTTATCATGCAAATACTCGGGCTCATGCTTATGGGGACCCTAACGCAGGTTTGAATTCTCAGCTGCATTATAAGAGACAGAT GTACCAACAGCAACCAGAGGAGTATAAAGACTGGAGCAGCGGTTCTGCTCAGGGAGTAATTGCTGCAGCACAGCACAGGCAGGAGGGGCCACGGAAGAGT CCAAGGCAGCAGCAGTTTCTTGACAGAGTACGGAGCCCTCTGAAAAATGACAAAGATGGTATGATGTATGGCCCACCAGTGGGGACTTACCATGACCCCA GTGCCCAGGAGGCTGGGCGCTGCCTAATGTCTAGTGATGGTCTGCCTAACAAGGGCATGGAATTAAAGCATGGCTCCCAGAAGTTACAAGAATCCTGTTG GGATCTTTCTCGGCAAACTTCTCCAGCCAAAAGCAGCGGTCCTCCAGGAATGTCCAGTCAAAAAAGGTATGGGCCGCCCCATGAGACTGATGGACATGGA CTAGCTGAGGCTACACAGTCATCCAAACCTGGTAGTGTTATGCTGAGACTTCCAGGCCAGGAGGATCATTCTTCTCAAAACCCCTTAATCATGAGGAGGC GTGTTCGTTCTTTTATCTCTCCCATTCCCAGTAAGAGACAGTCACAAGATGTAAAGAACAGTAGCACTGAAGATAAAGGTCGCCTCCTTCACTCATCAAA AGAAGGCGCTGATAAAGCATTCAATTCCTATGCCCATCTTTCTCACAGTCAGGATATCAAGTCTATCCCTAAGAGAGATTCCTCCAAGGACCTTCCAAGT CCAGATAGTAGAAACTGCCCTGCTGTTACCCTCACAAGCCCTGCTAAGACCAAAATACTGCCCCCACGGAAAGGACGGGGATTGAAATTGGAAGCTATAG TTCAGAAGATTACATCCCCAAATATTAGGAGGAGCGCATCTTCGAACAGTGCGGAGGCTGGGGGAGACACGGTTACGCTTGATGATATACTGTCTTTGAA GAGTGGTCCTCCTGAAGGTGGGAGTGTTGCTGTTCAGGATGCTGACATAGAGAAGAGAAAAGGTGAGGTGGCTTCGGACCTAGTCAGTCCAGCAAACCAG GAGTTGCACGTAGAGAAACCTCTTCCAAGGTCTTCAGAAGAGTGGCGTGGCAGCGTGGATGACAAAGTGAAGACAGAGACACATGCAGAAACAGTTACTG CCGGAAAGGAACCCCCTGGTGCCATGACATCCACAACCTCACAGAAGCCTGGTAGTAACCAAGGGAGACCAGATGGTTCCCTGGGTGGAACAGCACCTTT AATCTTTCCAGACTCAAAGAATGTACCTCCAGTGGGCATATTGGCCCCTGAGGCAAACCCCAAGGCTGAAGAGAAGGAGAACGATACAGTGACGATTTCA CCGAAGCAAGAGGGTTTCCCTCCAAAGGGATATTTCCCATCAGGAAAGAAGAAGGGGAGACCCATTGGTAGTGTGAATAAGCAAAAGAAACAGCAGCAGC CACCGCCTCCACCCCCTCAGCCCCCACAGATACCAGAAGGTTCTGCAGATGGAGAGCCAAAGCCAAAAAAACAGAGGCAAAGGAGGGAGAGAAGGAAGCC TGGGGCCCAGCCGAGGAAGCGAAAAACCAAACAAGCAGTTCCCATTGTGGAACCCCAAGAACCTGAGATCAAACTAAAATATGCCACCCAGCCACTGGAT AAAACTGATGCCAAGAACAAGTCTTTTTACCCTTACATCCATGTAGTAAATAAGTGTGAACTTGGAGCCGTTTGTACAATCATCAATGCTGAGGAAGAAG AACAGACCAAATTAGTGAGGGGCAGGAAGGGTCAGAGGTCACTGACCCCTCCACCTAGCAGCACTGAAAGCAAGGCGCTCCCGGCCTCGTCCTTTATGCT GCAGGGACCTGTTGTGACAGAGTCTTCGGTTATGGGGCACCTGGTTTGCTGTCTGTGTGGCAAGTGGGCCAGTTACCGGAACATGGGTGACCTCTTTGGA CCTTTTTATCCCCAAGATTATGCAGCCACTCTCCCGAAGAATCCACCTCCTAAGAGGGCCACAGAAATGCAGAGCAAAGTTAAGGTACGGCACAAAAGTG CTTCTAATGGCTCCAAGACGGACACTGAGGAGGAGGAAGAGCAGCAGCAGCAGCAGAAGGAGCAGAGAAGCCTGGCCGCACACCCCAGGTTTAAGCGGCG CCACCGCTCGGAAGACTGTGGTGGAGGCCCTCGGTCCCTGTCCAGGGGGCTCCCTTGTAAAAAAGCAGCCACTGAGGGCAGCAGTGAAAAGACTGTTTTG GACTCGAAGCCCTCCGTGCCCACCACTTCAGAAGGTGGCCCTGAGCTGGAGTTACAAATCCCTGAACTACCTCTTGACAGCAATGAATTTTGGGTCCATG AGGGTTGTATTCTCTGGGCCAATGGAATCTACCTGGTTTGTGGCAGGCTCTATGGCCTGCAGGAAGCGCTGGAAATAGCCAGAGAGATGAAATGTTCCCA CTGCCAGGAGGCAGGCGCCACCTTGGGCTGCTACAACAAAGGCTGCTCCTTCCGATACCATTACCCGTGTGCCATTGATGCAGATTGTTTGCTACATGAG GAGAACTTCTCGGTGAGGTGCCCTAAGCACAAGGTGAGACTGTGGAGATGAGAAGGTGGTGGACACTCGTGATGGAATGGAAATCGTCCTACCGTGCAGC CACACCCTGCCCTGCCCCGCCCCGCCCCGCCCGCGTGCCTGCCCATGCCAGCACTTCCTTAAGTTCTCACATCACACTCAAACCAGTGACACCACAGGAA AGAAAGACCCAAGACGTTGGAATGGCTGTTTCCATGGACACAATCTCCATAGTGACAATGTGGGGGGAGGGGGGAGGGGTGGGATGATGGGGAAAGGGTG GGGGGAATTAAAAGGGAGGGATAAATATATATATATAAATCTATTTTTAGTCTGGAAAGACTTTGTTTAAATGAAAGGTGCGCTATCCCTTTTGATTCTG TTTTAAAATTATCTCGTTAAAGATCTCCAAATTTGTTCCGATGACAAGTGAAATTTAAATGTGAGATTGAACTGAACAAACCCTCATCTCATGAAGGACG GGGTGTGTGTGTGGCGTTGATCTTTAGCCTGTCTCACACCAGTTCAGAAAACACTAGACCCAGGATTGAAAAAGCAAACCACAGCAGAACCATCCTTTTG TCATTAATTTGTCTCAAAGTGGGAAGGTTTTGGGGGAGGGGGAAATACAGGGATGGTCCATGTTTTCAAGAGTAGGGGAATGATGTTTAAACACAAAAAT AAATTTTTTTTCATTTCCAGAAACACTATTTATTTATGGTTTTTTTTTTTTAATTTTTTCTTTTTGGGGGTGAAATTGGCAGATGCCTGAGGTCATAGCT GTGTCCTGGGTCACTGTGGCTGGTGAGGACCTCAAGGACCCCATCAAGTGTACACAGCAGCAGCAAAATCAAGGGATGACCCTCCTCTGGGGCCCCCTGT CCTCAGCACATTCCAGGCAGCTGTGCCCTGACCCACAGGGACCCGTGGGGATGGGAGGAGGTCCAGGCCTGTGTTGCCAGAGCTGGCAGTGTGAGCTGTA GGCAGGGACGGGGAGGGACTGTCGCTGTGATCAGAGTGGGTTAAGCTGACCAGGAACACCCATTTAACCCCTTTTTCTTTTTGCTTTCATTTTTATAAAG GAAAAGAGGACCTGTCAGATAGGCAGCCCCATGCTACGTGATTCTTTATGTTGTGTTGTTTTGTTTTGTAAATTGTATAATTTTTAAATATCTGAGTTTT AAAAAAAGAAAAAAGTACAAAAAAATCTTGTTATGGCCTTAAGAAGGGGTTAGTGCATCTTTCAGGGGTCACTCTGCCATGGGGATAAAATAGCTGTTTC ACAAACAGTTTTATTTAAAAAAACAAAAAACAAAAAAAATCAAAAAATCAAAAAAATAATAAACTTCATTTTAACCTTG

refseq_TCF20.F2 (forward primer)
refseq_TCF20.R2 (reverse primer)
Single exon skipping

Frame 0

GPLIHLYSLHHLDLILFVPRRCVSNVFLSSISR RAVGLLLCC*TVCSPFGSKAVTTETSKATHRRYT AHPG*KSSALVRPRCSRILEVQVAVVAAVAVAV VVDDEEQQLLRQRWLARPLAIKVTRVSGKRLEI FTTWQATKTP*LQEPHSLLSEGLLGLCRAMDPPR GAALAISMGVRVMWASFKHSTLALAVCHIISRI TLGLSLQGVLSTNSRLPASSSSSKSSS*DNSFT SPISPCHRPLANQHPAHPIYSQCSGPQLCHPLLL VTS*EWVSLANTISLLLPPPPPPPSLHHSVLAS LDRAMMAVTM*MLDLSMKDTMWVLMHRLMEHNP ITAISLNL*RILNRQRFHKGPNRGSSSSNRSNNN TLLSM*CSILTLPPSCPCKAKWGSTTSLRFL*G PPCSFTRTSAPFLTLLQLPLWFSLQAVVLPHLL SCRLGRISSVGKAVCLWVPETEFYS*CLNSVQPH Q*CPVLILMLQASKGLD*KGYQKSD*QILG*VV *VL*VLKWPIFLTLSSTCYFLMP*LLRRRPPRG PHLPRKQIAAQILKAPHNLKNS*SPLWQSH*MEA APAVQRIKARECGN*VARAPALTPPTRVEPLRK LAPHRHKVLRMNPPDSMLVLPQEKRPPHQALRT CHCHPTGTQRLMRRLLG*LSPGKP*QVG*KSLVD KIKAPKRMILQPLKGHLAMVGQRKPVMHHFPSQ SLQEEEGAKETRMAITTPTIMEKEMARVATLQR ALVLRAELSLANLLEVCAIVTKIVSGQPCHEMSV AFLSILQGKKREISLAMGNERVEMKNSQASCRK CFRVTTTTLTGDILGVLKSIRGWLVA*KEPQGP MSWLVKPMN*LAGAF*TKALGLY*KIPTGAPGKG NQAAQLLK*NRSI*LTIQFPESLK*SLSHQHMS LGVPSLKEDQ*SVIFLH*DRLSGTQGLTHWDT* VPTPELGGMTVSIQL*VSRSFFLVVWCPWKPS*N PRAGR*KRKTLNSLNLKLVSTTRNLETTAILLA SSMSLTAAMPALEQQPMIPFQTMARKTADPRQC GGSLAELVVGRA*GVGPLLNIMTLQKN*KCLLGG AEAQGETLIT*IHT*PFQRGLTGVLYTLPFLPT QKPWPLLIMQILGLMLMGTLTQV*ILSCIIRDR CTNSNQRSIKTGAAVLLRE*LLQHSTGRRGHGRV QGSSSFLTEYGAL*KMTKMV*CMAHQWGLTMTP VPRRLGAA*CLVMVCLTRAWN*SMAPRSYKNPV GIFLGKLLQPKAAVLQECPVKKGMGRPMRLMDMD *LRLHSHPNLVVLC*DFQARRIILLKTP*S*GG VFVLLSLPFPVRDSHKM*RTVALKIKVASFTHQ KKALIKHSIPMPIFLTVRISSLSLREIPPRTFQV QIVETALLLPSQALLRPKYCPHGKDGD*NWKL* FRRLHPQILGGAHLRTVRRLGETRLRLMIYCL* RVVLLKVGVLLFRMLT*RREKVRWLRT*SVQQTR SCT*RNLFQGLQKSGVAAWMTK*RQRHMQKQLL PERNPLVP*HPQPHRSLVVTKGDQMVPWVEQHL *SFQTQRMYLQWAYWPLRQTPRLKRRRTIQ*RFH RSKRVSLQRDISHQERRRGDPLVV*ISKRNSSS HRLHPLSPHRYQKVLQMESQSQKNRGKGGREGS LGPSRGSEKPNKQFPLWNPKNLRSN*NMPPSHWI KLMPRTSLFTLTSM**ISVNLEPFVQSSMLRKK NRPN**GAGRVRGH*PLHLAALKARRSRPRPLC CRDLL*QSLRLWGTWFAVCVASGPVTGTWVTSLD LFIPKIMQPLSRRIHLLRGPQKCRAKLRYGTKV LLMAPRRTLRRRKSSSSSRRSREAWPHTPGLSG ATARKTVVEALGPCPGGSLVKKQPLRAAVKRLFW TRSPPCPPLQKVALSWSYKSLNYLLTAMNFGSM RVVFSGPMESTWFVAGSMACRKRWK*PER*NVP TARRQAPPWAATTKAAPSDTITRVPLMQIVCYMR RTSR*GALSTR*DCGDEKVVDTRDGMEIVLPCS HTLPCPAPPRPRACPCQHFLKFSHHTQTSDTTG KKDPRRWNGCFHGHNLHSDNVGGGGRGGMMGKGW GELKGRDKYIYINLFLVWKDFV*MKGALSLLIL F*NYLVKDLQICSDDK*NLNVRLN*TNPHLMKD GVCVWR*SLACLTPVQKTLDPGLKKQTTAEPSFC H*FVSKWEGFGGGGNTGMVHVFKSRGMMFKHKN KFFFISRNTIYLWFFFFNFFFLGVKLADA*GHS CVLGHCGW*GPQGPHQVYTAAAKSRDDPPLGPPV LSTFQAAVP*PTGTRGDGRRSRPVLPELAV*AV GRDGEGLSL*SEWVKLTRNTHLTPFSFCFHFYK GKEDLSDRQPHAT*FFMLCCFVL*IV*FLNI*VL KKEKSTKKSCYGLKKGLVHLSGVTLPWG*NSCF TNSFI*KNKKQKKSKNQKNNKLHFNL

Frame 1

GL*FIFIPSII*T*FYLYQGDACLMFFFLLFLG GLLACCCAAEQYAVLSGAKQLPRKPAKLPTGGT RLIPARRVQPSSGPDVPEFWRYRWQ*WQQWQWQW WWTTRSSSCCGSDG*RDLWPSRLPGFQERGWRF LLHGRQQRPRDYRNPTASSAKAFWACAELWTPP GEQLWQSVWE*GSCGPVSSTALWPWRCVTLSAGL HWAFLSRECSVPTAGFQPAAAAASPAVETTALP VPSAPATGHWPTSIQLIPSTANAAALNSAILCC WLPVKSGSVWPTLSVFCFLLLLLLLPFTTAF*PV WTEL*WQLQCECWISV*RTQCGF*CTGLWNTIQ LQLSASIYEEF*TGKDSTRDPTGAAAAATAATT TPFSACDAVY*RCHQAAPAKPSGAVQPA*GSCEV PHAVSPELQPHF*PFSSCLCGSVSKL*FYPISS HADWGESPVWARQCAYGFQKQNFTVNASTQSNP INDAQS*FSCCRLQRVWTRRGTRKATDRSWVE*F ECSEYSSGQSS*HCPAHVTF*CPDSSEEDLQEA LIFQESR*LHKF*RLLTT*RTAEVPYGRVIRWR LLQQFRGSRRESAATKWPEHQL*HHLQGWSL*ES WLLTGTRCSE*TPQTQC*SCRKRRGHLTRR*GH AIVIRREPKG**EDCWGDCLPGSHDRSGRKAWW TR*RLPRG*SCSHSKAT*QWWGKGNQSCITSPAR ASRRRREQRKQEWR*QLQP*WRRKWPEWPLCSG PWFYEQN*A*QISWKSAL*LQR*FRVSRATKCQ WLSSVSYRARKGRFHWPWGTKG*K*KIPKPPAGS ASGLPPPP*QEIF*EYSRASGDGW*PRRNHKAQ CLG*SNQ*IS*QGPSEQKHWVSIRKSPLGPLGK EIKQHSS*NETDQFD*LSNSQKV*NRASVIST*A WGFPL*KKISDL*YFSTKTDCQGPRGSLTGTHE CRHQNWEE*PSQSNFKSVGHSSWWFGVHGNQAE IPERADKRGRL*TV*ISS*FQQQEIWRPLPSS*H QA*VLPRQCQPWSSNP*FPFRLWPARQQTHANA AGPWQSWWSGGHEGSVPFSIS*LCRKIENVSWA EQRPRGRPSSHESTHDLFREG*PEFFTHSLFSQL RNPGLCLSCKYSGSCLWGP*RRFEFSAAL*ETD VPTATRGV*RLEQRFCSGSNCCSTAQAGGATEE SKAAAVS*QSTEPSEK*QRWYDVWPTSGDLP*PQ CPGGWALPNV**WSA*QGHGIKAWLPEVTRILL GSFSANFSSQKQRSSRNVQSKKVWAAP*D*WTW TS*GYTVIQTW*CYAETSRPGGSFFSKPLNHEEA CSFFYLSHSQ*ETVTRCKEQ*H*R*RSPPSLIK RRR**SIQFLCPSFSQSGYQVYP*ERFLQGPSK SR**KLPCCYPHKPC*DQNTAPTERTGIEIGSYS SEDYIPKY*EERIFEQCGGWGRHGYA**YTVFE EWSS*RWECCCSGC*HREEKR*GGFGPSQSSKP GVARRETSSKVFRRVAWQRG*QSEDRDTCRNSYC RKGTPWCHDIHNLTEAW**PRETRWFPGWNSTF NLSRLKECTSSGHIGP*GKPQG*REGERYSDDF TEARGFPSKGIFPIRKEEGETHW*CE*AKETAAA TASTPSAPTDTRRFCRWRAKAKKTEAKEGEKEA WGPAEEAKNQTSSSHCGTPRT*DQTKICHPATG *N*CQEQVFLPLHPCSK*V*TWSRLYNHQC*GRR TDQISEGQEGSEVTDPST*QH*KQGAPGLVLYA AGTCCDRVFGYGAPGLLSVWQVGQLPEHG*PLW TFLSPRLCSHSPEESTS*EGHRNAEQS*GTAQKC F*WLQDGH*GGGRAAAAAEGAEKPGRTPQV*AA PPLGRLWWRPSVPVQGAPL*KSSH*GQQ*KDCF GLEALRAHHFRRWP*AGVTNP*TTS*QQ*ILGP* GLYSLGQWNLPGLWQALWPAGSAGNSQRDEMFP LPGGRRHLGLLQQRLLLPIPLPVCH*CRLFAT* GELLGEVP*AQGETVEMRRWWTLVMEWKSSYRAA TPCPAPPRPARVPAHASTSLSSHITLKPVTPQE RKTQDVGMAVSMDTISIVTMWGEGGGVG*WGKG GGN*KGGINIYI*IYF*SGKTLFK*KVRYPF*FC FKIISLKISKFVPMTSEI*M*D*TEQTLIS*RT GCVCGVDL*PVSHQFRKH*TQD*KSKPQQNHPF VINLSQSGKVLGEGEIQGWSMFSRVGE*CLNTKI NFFSFPETLFIYGFFFLIFSFWG*NWQMPEVIA VSWVTVAGEDLKDPIKCTQQQQNQGMTLLWGPL SSAHSRQLCPDPQGPVGMGGGPGLCCQSWQCEL* AGTGRDCRCDQSGLS*PGTPI*PLFLFAFIFIK EKRTCQIGSPMLRDSLCCVVLFCKLYNF*ISEF *KKKKVQKNLVMALRRG*CIFQGSLCHGDKIAVS QTVLFKKTKNKKNQKIKKIINFILTL

Frame 2

ASDSSLFPPSSRLDFICTKEMRV*CFSFFYF*E GCWPAAVLLNSMQSFREQSSYHGNQQSYPQEVH GSSRLEEFSPRQAQMFQNFGGTGGSSGSSGSGS GGGRRGAAAAAAAMASETSGHQGYQGFRKEAGDF YYMAGNKDPVTTGTPQPPQRRPSGPVQSYGPPQ GSSFGNQYGSEGHVGQFQAQHSGLGGVSHYQQD YTGPFSPGSAQYQQQASSQQQQQQVQQLRQQLYQ SHQPLPQATGQPASSSSHLQPMQRPSTLPSSAA GYQLRVGQFGQHYQSSASSSSSSSFPSPQRFSQ SGQSYDGSYNVNAGSQYEGHNVGSNAQAYGTQSN YSYQPQSMKNFEQAKIPQGTQQGQQQQQPQQQQ HPSQHVMQYTNAATKLPLQSQVGQYNQPEVPVR SPMQFHQNFSPISNPSPAASVVQSPSCSSTPSPL MQTGENLQCGQGSVPMGSRNRILQLMPQLSPTP SMMPSPNSHAAGFKGFGLEGVPEKRLTDPGLSS LSALSTQVANLPNTVQHMLLSDALTPQKKTSKRP SSSKKADSCTNSEGSSQPEEQLKSPMAESLDGG CSSSSEDQGERVRQLSGQSTSSDTTYKGGASEK AGSSPAQGAQNEPPRLNASPAAREEATSPGAKDM PLSSDGNPKVNEKTVGVIVSREAMTGRVEKPGG QDKGSQEDDPAATQRPPSNGGAKETSHASLPQP EPPGGGGSKGNKNGDNNSNHNGEGNGQSGHSAAG PGFTSRTEPSKSPGSLRYSYKDSFGSAVPRNVS GFPQYPTGQEKGDFTGHGERKGRNEKFPSLLQE VLQGYHHHPDRRYSRSTQEHQGMAGSLEGTTRPN VLVSQTNELASRGLLNKSIGSLLENPHWGPWER KSSSTAPEMKQINLTDYPIPRKFEIEPQSSAHE PGGSLSERRSVICDISPLRQIVRDPGAHSLGHMS ADTRIGRNDRLNPTLSQSVILPGGLVSMETKLK SQSGQIKEEDFEQSKSQASFNNKKSGDHCHPPS IKHESYRGNASPGAATHDSLSDYGPQDSRPTPMR RVPGRVGGREGMRGRSPSQYHDFAEKLKMSPGR SRGPGGDPHHMNPHMTFSERANRSSLHTPFSPN SETLASAYHANTRAHAYGDPNAGLNSQLHYKRQM YQQQPEEYKDWSSGSAQGVIAAAQHRQEGPRKS PRQQQFLDRVRSPLKNDKDGMMYGPPVGTYHDP SAQEAGRCLMSSDGLPNKGMELKHGSQKLQESCW DLSRQTSPAKSSGPPGMSSQKRYGPPHETDGHG LAEATQSSKPGSVMLRLPGQEDHSSQNPLIMRR RVRSFISPIPSKRQSQDVKNSSTEDKGRLLHSSK EGADKAFNSYAHLSHSQDIKSIPKRDSSKDLPS PDSRNCPAVTLTSPAKTKILPPRKGRGLKLEAI VQKITSPNIRRSASSNSAEAGGDTVTLDDILSLK SGPPEGGSVAVQDADIEKRKGEVASDLVSPANQ ELHVEKPLPRSSEEWRGSVDDKVKTETHAETVT AGKEPPGAMTSTTSQKPGSNQGRPDGSLGGTAPL IFPDSKNVPPVGILAPEANPKAEEKENDTVTIS PKQEGFPPKGYFPSGKKKGRPIGSVNKQKKQQQ PPPPPPQPPQIPEGSADGEPKPKKQRQRRERRKP GAQPRKRKTKQAVPIVEPQEPEIKLKYATQPLD KTDAKNKSFYPYIHVVNKCELGAVCTIINAEEE EQTKLVRGRKGQRSLTPPPSSTESKALPASSFML QGPVVTESSVMGHLVCCLCGKWASYRNMGDLFG PFYPQDYAATLPKNPPPKRATEMQSKVKVRHKS ASNGSKTDTEEEEEQQQQQKEQRSLAAHPRFKRR HRSEDCGGGPRSLSRGLPCKKAATEGSSEKTVL DSKPSVPTTSEGGPELELQIPELPLDSNEFWVH EGCILWANGIYLVCGRLYGLQEALEIAREMKCSH CQEAGATLGCYNKGCSFRYHYPCAIDADCLLHE ENFSVRCPKHKVRLWR*EGGGHS*WNGNRPTVQ PHPALPRPAPPACLPMPALP*VLTSHSNQ*HHRK ERPKTLEWLFPWTQSP**QCGGRGEGWDDGERV GGIKREG*IYIYKSIFSLERLCLNERCAIPFDS VLKLSR*RSPNLFR*QVKFKCEIELNKPSSHEGR GVCVALIFSLSHTSSENTRPRIEKANHSRTILL SLICLKVGRFWGRGKYRDGPCFQE*GNDV*TQK *IFFHFQKHYLFMVFFF*FFLFGGEIGRCLRS*L CPGSLWLVRTSRTPSSVHSSSKIKG*PSSGAPC PQHIPGSCALTHRDPWGWEEVQACVARAGSVSC RQGRGGTVAVIRVG*ADQEHPFNPFFFLLSFL*R KRGPVR*AAPCYVILYVVLFCFVNCIIFKYLSF KKRKKYKKILLWP*EGVSASFRGHSAMGIK*LF HKQFYLKKQKTKKIKKSKK**TSF*P

Sequence NM_005650

GGGCCTCTGATTCATCTTTATTCCCTCCATCATCTAGACTTGATTTTATTTGTACCAAGGAGATGCGTGTCTAATGTTTTTCTTTCTTCTATTTCTAGGA GGGCTGTTGGCCTGCTGCTGTGCTGCTGAACAGTATGCAGTCCTTTCGGGAGCAAAGCAGTTACCACGGAAACCAGCAAAGCTACCCACAGGAGGTACAC GGCTCATCCCGGCTAGAAGAGTTCAGCCCTCGTCAGGCCCAGATGTTCCAGAATTTTGGAGGTACAGGTGGCAGTAGTGGCAGCAGTGGCAGTGGCAGTG GTGGTGGACGACGAGGAGCAGCAGCTGCTGCGGCAGCGATGGCTAGCGAGACCTCTGGCCATCAAGGTTACCAGGGTTTCAGGAAAGAGGCTGGAGATTT TTACTACATGGCAGGCAACAAAGACCCCGTGACTACAGGAACCCCACAGCCTCCTCAGCGAAGGCCTTCTGGGCCTGTGCAGAGCTATGGACCCCCCCAG GGGAGCAGCTTTGGCAATCAGTATGGGAGTGAGGGTCATGTGGGCCAGTTTCAAGCACAGCACTCTGGCCTTGGCGGTGTGTCACATTATCAGCAGGATT ACACTGGGCCTTTCTCTCCAGGGAGTGCTCAGTACCAACAGCAGGCTTCCAGCCAGCAGCAGCAGCAGCAAGTCCAGCAGTTGAGACAACAGCTTTACCA GTCCCATCAGCCCCTGCCACAGGCCACTGGCCAACCAGCATCCAGCTCATCCCATCTACAGCCAATGCAGCGGCCCTCAACTCTGCCATCCTCTGCTGCT GGTTACCAGTTAAGAGTGGGTCAGTTTGGCCAACACTATCAGTCTTCTGCTTCCTCCTCCTCCTCCTCCTCCTTCCCTTCACCACAGCGTTTTAGCCAGT CTGGACAGAGCTATGATGGCAGTTACAATGTGAATGCTGGATCTCAGTATGAAGGACACAATGTGGGTTCTAATGCACAGGCTTATGGAACACAATCCAA TTACAGCTATCAGCCTCAATCTATGAAGAATTTTGAACAGGCAAAGATTCCACAAGGGACCCAACAGGGGCAGCAGCAGCAGCAACCGCAGCAACAACAA CACCCTTCTCAGCATGTGATGCAGTATACTAACGCTGCCACCAAGCTGCCCCTGCAAAGCCAAGTGGGGCAGTACAACCAGCCTGAGGTTCCTGTGAGGT CCCCCATGCAGTTTCACCAGAACTTCAGCCCCATTTCTAACCCTTCTCCAGCTGCCTCTGTGGTTCAGTCTCCAAGCTGTAGTTCTACCCCATCTCCTCT CATGCAGACTGGGGAGAATCTCCAGTGTGGGCAAGGCAGTGTGCCTATGGGTTCCAGAAACAGAATTTTACAGTTAATGCCTCAACTCAGTCCAACCCCA TCAATGATGCCCAGTCCTAATTCTCATGCTGCAGGCTTCAAAGGGTTTGGACTAGAAGGGGTACCAGAAAAGCGACTGACAGATCCTGGGTTGAGTAGTT TGAGTGCTCTGAGTACTCAAGTGGCCAATCTTCCTAACACTGTCCAGCACATGTTACTTTCTGATGCCCTGACTCCTCAGAAGAAGACCTCCAAGAGGCC CTCATCTTCCAAGAAAGCAGATAGCTGCACAAATTCTGAAGGCTCCTCACAACCTGAAGAACAGCTGAAGTCCCCTATGGCAGAGTCATTAGATGGAGGC TGCTCCAGCAGTTCAGAGGATCAAGGCGAGAGAGTGCGGCAACTAAGTGGCCAGAGCACCAGCTCTGACACCACCTACAAGGGTGGAGCCTCTGAGAAAG CTGGCTCCTCACCGGCACAAGGTGCTCAGAATGAACCCCCCAGACTCAATGCTAGTCCTGCCGCAAGAGAAGAGGCCACCTCACCAGGCGCTAAGGACAT GCCATTGTCATCCGACGGGAACCCAAAGGTTAATGAGAAGACTGTTGGGGTGATTGTCTCCCGGGAAGCCATGACAGGTCGGGTAGAAAAGCCTGGTGGA CAAGATAAAGGCTCCCAAGAGGATGATCCTGCAGCCACTCAAAGGCCACCTAGCAATGGTGGGGCAAAGGAAACCAGTCATGCATCACTTCCCCAGCCAG AGCCTCCAGGAGGAGGAGGGAGCAAAGGAAACAAGAATGGCGATAACAACTCCAACCATAATGGAGAAGGAAATGGCCAGAGTGGCCACTCTGCAGCGGG CCCTGGTTTTACGAGCAGAACTGAGCCTAGCAAATCTCCTGGAAGTCTGCGCTATAGTTACAAAGATAGTTTCGGGTCAGCCGTGCCACGAAATGTCAGT GGCTTTCCTCAGTATCCTACAGGGCAAGAAAAGGGAGATTTCACTGGCCATGGGGAACGAAAGGGTAGAAATGAAAAATTCCCAAGCCTCCTGCAGGAAG TGCTTCAGGGTTACCACCACCACCCTGACAGGAGATATTCTAGGAGTACTCAAGAGCATCAGGGGATGGCTGGTAGCCTAGAAGGAACCACAAGGCCCAA TGTCTTGGTTAGTCAAACCAATGAATTAGCTAGCAGGGGCCTTCTGAACAAAAGCATTGGGTCTCTATTAGAAAATCCCCACTGGGGCCCCTGGGAAAGG AAATCAAGCAGCACAGCTCCTGAAATGAAACAGATCAATTTGACTGACTATCCAATTCCCAGAAAGTTTGAAATAGAGCCTCAGTCATCAGCACATGAGC CTGGGGGTTCCCTCTCTGAAAGAAGATCAGTGATCTGTGATATTTCTCCACTAAGACAGATTGTCAGGGACCCAGGGGCTCACTCACTGGGACACATGAG TGCCGACACCAGAATTGGGAGGAATGACCGTCTCAATCCAACTTTAAGTCAGTCGGTCATTCTTCCTGGTGGTTTGGTGTCCATGGAAACCAAGCTGAAA TCCCAGAGCGGGCAGATAAAAGAGGAAGACTTTGAACAGTCTAAATCTCAAGCTAGTTTCAACAACAAGAAATCTGGAGACCACTGCCATCCTCCTAGCA TCAAGCATGAGTCTTACCGCGGCAATGCCAGCCCTGGAGCAGCAACCCATGATTCCCTTTCAGACTATGGCCCGCAAGACAGCAGACCCACGCCAATGCG GCGGGTCCCTGGCAGAGTTGGTGGTCGGGAGGGCATGAGGGGTCGGTCCCCTTCTCAATATCATGACTTTGCAGAAAAATTGAAAATGTCTCCTGGGCGG AGCAGAGGCCCAGGGGGAGACCCTCATCACATGAATCCACACATGACCTTTTCAGAGAGGGCTAACCGGAGTTCTTTACACACTCCCTTTTCTCCCAACT CAGAAACCCTGGCCTCTGCTTATCATGCAAATACTCGGGCTCATGCTTATGGGGACCCTAACGCAGGTTTGAATTCTCAGCTGCATTATAAGAGACAGAT GTACCAACAGCAACCAGAGGAGTATAAAGACTGGAGCAGCGGTTCTGCTCAGGGAGTAATTGCTGCAGCACAGCACAGGCAGGAGGGGCCACGGAAGAGT CCAAGGCAGCAGCAGTTTCTTGACAGAGTACGGAGCCCTCTGAAAAATGACAAAGATGGTATGATGTATGGCCCACCAGTGGGGACTTACCATGACCCCA GTGCCCAGGAGGCTGGGCGCTGCCTAATGTCTAGTGATGGTCTGCCTAACAAGGGCATGGAATTAAAGCATGGCTCCCAGAAGTTACAAGAATCCTGTTG GGATCTTTCTCGGCAAACTTCTCCAGCCAAAAGCAGCGGTCCTCCAGGAATGTCCAGTCAAAAAAGGTATGGGCCGCCCCATGAGACTGATGGACATGGA CTAGCTGAGGCTACACAGTCATCCAAACCTGGTAGTGTTATGCTGAGACTTCCAGGCCAGGAGGATCATTCTTCTCAAAACCCCTTAATCATGAGGAGGC GTGTTCGTTCTTTTATCTCTCCCATTCCCAGTAAGAGACAGTCACAAGATGTAAAGAACAGTAGCACTGAAGATAAAGGTCGCCTCCTTCACTCATCAAA AGAAGGCGCTGATAAAGCATTCAATTCCTATGCCCATCTTTCTCACAGTCAGGATATCAAGTCTATCCCTAAGAGAGATTCCTCCAAGGACCTTCCAAGT CCAGATAGTAGAAACTGCCCTGCTGTTACCCTCACAAGCCCTGCTAAGACCAAAATACTGCCCCCACGGAAAGGACGGGGATTGAAATTGGAAGCTATAG TTCAGAAGATTACATCCCCAAATATTAGGAGGAGCGCATCTTCGAACAGTGCGGAGGCTGGGGGAGACACGGTTACGCTTGATGATATACTGTCTTTGAA GAGTGGTCCTCCTGAAGGTGGGAGTGTTGCTGTTCAGGATGCTGACATAGAGAAGAGAAAAGGTGAGGTGGCTTCGGACCTAGTCAGTCCAGCAAACCAG GAGTTGCACGTAGAGAAACCTCTTCCAAGGTCTTCAGAAGAGTGGCGTGGCAGCGTGGATGACAAAGTGAAGACAGAGACACATGCAGAAACAGTTACTG CCGGAAAGGAACCCCCTGGTGCCATGACATCCACAACCTCACAGAAGCCTGGTAGTAACCAAGGGAGACCAGATGGTTCCCTGGGTGGAACAGCACCTTT AATCTTTCCAGACTCAAAGAATGTACCTCCAGTGGGCATATTGGCCCCTGAGGCAAACCCCAAGGCTGAAGAGAAGGAGAACGATACAGTGACGATTTCA CCGAAGCAAGAGGGTTTCCCTCCAAAGGGATATTTCCCATCAGGAAAGAAGAAGGGGAGACCCATTGGTAGTGTGAATAAGCAAAAGAAACAGCAGCAGC CACCGCCTCCACCCCCTCAGCCCCCACAGATACCAGAAGGTTCTGCAGATGGAGAGCCAAAGCCAAAAAAACAGAGGCAAAGGAGGGAGAGAAGGAAGCC TGGGGCCCAGCCGAGGAAGCGAAAAACCAAACAAGCAGTTCCCATTGTGGAACCCCAAGAACCTGAGATCAAACTAAAATATGCCACCCAGCCACTGGAT AAAACTGATGCCAAGAACAAGTCTTTTTACCCTTACATCCATGTAGTAAATAAGTGTGAACTTGGAGCCGTTTGTACAATCATCAATGCTGAGGAAGAAG AACAGACCAAATTAGTGAGGGGCAGGAAGGGTCAGAGGTCACTGACCCCTCCACCTAGCAGCACTGAAAGCAAGGCGCTCCCGGCCTCGTCCTTTATGCT GCAGGGACCTGTTGTGACAGAGTCTTCGGTTATGGGGCACCTGGTTTGCTGTCTGTGTGGCAAGTGGGCCAGTTACCGGAACATGGGTGACCTCTTTGGA CCTTTTTATCCCCAAGATTATGCAGCCACTCTCCCGAAGAATCCACCTCCTAAGAGGGCCACAGAAATGCAGAGCAAAGTTAAGGTACGGCACAAAAGTG CTTCTAATGGCTCCAAGACGGACACTGAGGAGGAGGAAGAGCAGCAGCAGCAGCAGAAGGAGCAGAGAAGCCTGGCCGCACACCCCAGGTTTAAGCGGCG CCACCGCTCGGAAGACTGTGGTGGAGGCCCTCGGTCCCTGTCCAGGGGGCTCCCTTGTAAAAAAGCAGCCACTGAGGGCAGCAGTGAAAAGACTGTTTTG GACTCGAAGCCCTCCGTGCCCACCACTTCAGAAGGTGGCCCTGAGCTGGAGTTACAAATCCCTGAACTACCTCTTGACAGCAATGAATTTTGGGTCCATG AGGGTTGTATTCTCTGGGCCAATGGAATCTACCTGGTTTGTGGCAGGCTCTATGGCCTGCAGGAAGCGCTGGAAATAGCCAGAGAGATGAAATGTTCCCA CTGCCAGGAGGCAGGCGCCACCTTGGGCTGCTACAACAAAGGCTGCTCCTTCCGATACCATTACCCGTGTGCCATTGATGCAGATTGTTTGCTACATGAG GAGAACTTCTCGGTGAGGTGCCCTAAGCACAAGCCTCCCCTTCCGTGCCCTCTCCCCCCCTTGCAGAACAAGACCGCGAAAGGCAGCCTCAGCACAGAGC AGTCGGAGCGGGGGTGAGGGGGGCAGTGTGCTCGTGGGAATGGAAAGGACAGCAAGCACAGGTGAGACTGTGGAGATGAGAAGGTGGTGGACACTCGTGA TGGAATGGAAATCGTCCTACCGTGCAGCCACACCCTGCCCTGCCCCGCCCCGCCCCGCCCGCGTGCCTGCCCATGCCAGCACTTCCTTAAGTTCTCACAT CACACTCAAACCAGTGACACCACAGGAAAGAAAGACCCAAGACGTTGGAATGGCTGTTTCCATGGACACAATCTCCATAGTGACAATGTGGGGGGAGGGG GGAGGGGTGGGATGATGGGGAAAGGGTGGGGGGAATTAAAAGGGAGGGATAAATATATATATATAAATCTATTTTTAGTCTGGAAAGACTTTGTTTAAAT GAAAGGTGCGCTATCCCTTTTGATTCTGTTTTAAAATTATCTCGTTAAAGATCTCCAAATTTGTTCCGATGACAAGTGAAATTTAAATGTGAGATTGAAC TGAACAAACCCTCATCTCATGAAGGACGGGGTGTGTGTGTGGCGTTGATCTTTAGCCTGTCTCACACCAGTTCAGAAAACACTAGACCCAGGATTGAAAA AGCAAACCACAGCAGAACCATCCTTTTGTCATTAATTTGTCTCAAAGTGGGAAGGTTTTGGGGGAGGGGGAAATACAGGGATGGTCCATGTTTTCAAGAG TAGGGGAATGATGTTTAAACACAAAAATAAATTTTTTTTCATTTCCAGAAACACTATTTATTTATGGTTTTTTTTTTTTAATTTTTTCTTTTTGGGGGTG AAATTGGCAGATGCCTGAGGTCATAGCTGTGTCCTGGGTCACTGTGGCTGGTGAGGACCTCAAGGACCCCATCAAGTGTACACAGCAGCAGCAAAATCAA GGGATGACCCTCCTCTGGGGCCCCCTGTCCTCAGCACATTCCAGGCAGCTGTGCCCTGACCCACAGGGACCCGTGGGGATGGGAGGAGGTCCAGGCCTGT GTTGCCAGAGCTGGCAGTGTGAGCTGTAGGCAGGGACGGGGAGGGACTGTCGCTGTGATCAGAGTGGGTTAAGCTGACCAGGAACACCCATTTAACCCCT TTTTCTTTTTGCTTTCATTTTTATAAAGGAAAAGAGGACCTGTCAGATAGGCAGCCCCATGCTACGTGATTCTTTATGTTGTGTTGTTTTGTTTTGTAAA TTGTATAATTTTTAAATATCTGAGTTTTAAAAAAAGAAAAAAGTACAAAAAAATCTTGTTATGGCCTTAAGAAGGGGTTAGTGCATCTTTCAGGGGTCAC TCTGCCATGGGGATAAAATAGCTGTTTCACAAACAGTTTTATTTAAAAAAACAAAAAACAAAAAAAATCAAAAAATCAAAAAAATAATAAACTTCATTTT AACCTTG

refseq_TCF20.F2 (forward primer)
refseq_TCF20.R2 (reverse primer)
Single exon skipping

Frame 0

GPLIHLYSLHHLDLILFVPRRCVSNVFLSSISR RAVGLLLCC*TVCSPFGSKAVTTETSKATHRRYT AHPG*KSSALVRPRCSRILEVQVAVVAAVAVAV VVDDEEQQLLRQRWLARPLAIKVTRVSGKRLEI FTTWQATKTP*LQEPHSLLSEGLLGLCRAMDPPR GAALAISMGVRVMWASFKHSTLALAVCHIISRI TLGLSLQGVLSTNSRLPASSSSSKSSS*DNSFT SPISPCHRPLANQHPAHPIYSQCSGPQLCHPLLL VTS*EWVSLANTISLLLPPPPPPPSLHHSVLAS LDRAMMAVTM*MLDLSMKDTMWVLMHRLMEHNP ITAISLNL*RILNRQRFHKGPNRGSSSSNRSNNN TLLSM*CSILTLPPSCPCKAKWGSTTSLRFL*G PPCSFTRTSAPFLTLLQLPLWFSLQAVVLPHLL SCRLGRISSVGKAVCLWVPETEFYS*CLNSVQPH Q*CPVLILMLQASKGLD*KGYQKSD*QILG*VV *VL*VLKWPIFLTLSSTCYFLMP*LLRRRPPRG PHLPRKQIAAQILKAPHNLKNS*SPLWQSH*MEA APAVQRIKARECGN*VARAPALTPPTRVEPLRK LAPHRHKVLRMNPPDSMLVLPQEKRPPHQALRT CHCHPTGTQRLMRRLLG*LSPGKP*QVG*KSLVD KIKAPKRMILQPLKGHLAMVGQRKPVMHHFPSQ SLQEEEGAKETRMAITTPTIMEKEMARVATLQR ALVLRAELSLANLLEVCAIVTKIVSGQPCHEMSV AFLSILQGKKREISLAMGNERVEMKNSQASCRK CFRVTTTTLTGDILGVLKSIRGWLVA*KEPQGP MSWLVKPMN*LAGAF*TKALGLY*KIPTGAPGKG NQAAQLLK*NRSI*LTIQFPESLK*SLSHQHMS LGVPSLKEDQ*SVIFLH*DRLSGTQGLTHWDT* VPTPELGGMTVSIQL*VSRSFFLVVWCPWKPS*N PRAGR*KRKTLNSLNLKLVSTTRNLETTAILLA SSMSLTAAMPALEQQPMIPFQTMARKTADPRQC GGSLAELVVGRA*GVGPLLNIMTLQKN*KCLLGG AEAQGETLIT*IHT*PFQRGLTGVLYTLPFLPT QKPWPLLIMQILGLMLMGTLTQV*ILSCIIRDR CTNSNQRSIKTGAAVLLRE*LLQHSTGRRGHGRV QGSSSFLTEYGAL*KMTKMV*CMAHQWGLTMTP VPRRLGAA*CLVMVCLTRAWN*SMAPRSYKNPV GIFLGKLLQPKAAVLQECPVKKGMGRPMRLMDMD *LRLHSHPNLVVLC*DFQARRIILLKTP*S*GG VFVLLSLPFPVRDSHKM*RTVALKIKVASFTHQ KKALIKHSIPMPIFLTVRISSLSLREIPPRTFQV QIVETALLLPSQALLRPKYCPHGKDGD*NWKL* FRRLHPQILGGAHLRTVRRLGETRLRLMIYCL* RVVLLKVGVLLFRMLT*RREKVRWLRT*SVQQTR SCT*RNLFQGLQKSGVAAWMTK*RQRHMQKQLL PERNPLVP*HPQPHRSLVVTKGDQMVPWVEQHL *SFQTQRMYLQWAYWPLRQTPRLKRRRTIQ*RFH RSKRVSLQRDISHQERRRGDPLVV*ISKRNSSS HRLHPLSPHRYQKVLQMESQSQKNRGKGGREGS LGPSRGSEKPNKQFPLWNPKNLRSN*NMPPSHWI KLMPRTSLFTLTSM**ISVNLEPFVQSSMLRKK NRPN**GAGRVRGH*PLHLAALKARRSRPRPLC CRDLL*QSLRLWGTWFAVCVASGPVTGTWVTSLD LFIPKIMQPLSRRIHLLRGPQKCRAKLRYGTKV LLMAPRRTLRRRKSSSSSRRSREAWPHTPGLSG ATARKTVVEALGPCPGGSLVKKQPLRAAVKRLFW TRSPPCPPLQKVALSWSYKSLNYLLTAMNFGSM RVVFSGPMESTWFVAGSMACRKRWK*PER*NVP TARRQAPPWAATTKAAPSDTITRVPLMQIVCYMR RTSR*GALSTSLPFRALSPPCRTRPRKAASAQS SRSGGEGGSVLVGMERTASTGETVEMRRWWTLV MEWKSSYRAATPCPAPPRPARVPAHASTSLSSHI TLKPVTPQERKTQDVGMAVSMDTISIVTMWGEG GGVG*WGKGGGN*KGGINIYI*IYF*SGKTLFK *KVRYPF*FCFKIISLKISKFVPMTSEI*M*D*T EQTLIS*RTGCVCGVDL*PVSHQFRKH*TQD*K SKPQQNHPFVINLSQSGKVLGEGEIQGWSMFSR VGE*CLNTKINFFSFPETLFIYGFFFLIFSFWG* NWQMPEVIAVSWVTVAGEDLKDPIKCTQQQQNQ GMTLLWGPLSSAHSRQLCPDPQGPVGMGGGPGL CCQSWQCEL*AGTGRDCRCDQSGLS*PGTPI*PL FLFAFIFIKEKRTCQIGSPMLRDSLCCVVLFCK LYNF*ISEF*KKKKVQKNLVMALRRG*CIFQGS LCHGDKIAVSQTVLFKKTKNKKNQKIKKIINFIL TL

Frame 1

GL*FIFIPSII*T*FYLYQGDACLMFFFLLFLG GLLACCCAAEQYAVLSGAKQLPRKPAKLPTGGT RLIPARRVQPSSGPDVPEFWRYRWQ*WQQWQWQW WWTTRSSSCCGSDG*RDLWPSRLPGFQERGWRF LLHGRQQRPRDYRNPTASSAKAFWACAELWTPP GEQLWQSVWE*GSCGPVSSTALWPWRCVTLSAGL HWAFLSRECSVPTAGFQPAAAAASPAVETTALP VPSAPATGHWPTSIQLIPSTANAAALNSAILCC WLPVKSGSVWPTLSVFCFLLLLLLLPFTTAF*PV WTEL*WQLQCECWISV*RTQCGF*CTGLWNTIQ LQLSASIYEEF*TGKDSTRDPTGAAAAATAATT TPFSACDAVY*RCHQAAPAKPSGAVQPA*GSCEV PHAVSPELQPHF*PFSSCLCGSVSKL*FYPISS HADWGESPVWARQCAYGFQKQNFTVNASTQSNP INDAQS*FSCCRLQRVWTRRGTRKATDRSWVE*F ECSEYSSGQSS*HCPAHVTF*CPDSSEEDLQEA LIFQESR*LHKF*RLLTT*RTAEVPYGRVIRWR LLQQFRGSRRESAATKWPEHQL*HHLQGWSL*ES WLLTGTRCSE*TPQTQC*SCRKRRGHLTRR*GH AIVIRREPKG**EDCWGDCLPGSHDRSGRKAWW TR*RLPRG*SCSHSKAT*QWWGKGNQSCITSPAR ASRRRREQRKQEWR*QLQP*WRRKWPEWPLCSG PWFYEQN*A*QISWKSAL*LQR*FRVSRATKCQ WLSSVSYRARKGRFHWPWGTKG*K*KIPKPPAGS ASGLPPPP*QEIF*EYSRASGDGW*PRRNHKAQ CLG*SNQ*IS*QGPSEQKHWVSIRKSPLGPLGK EIKQHSS*NETDQFD*LSNSQKV*NRASVIST*A WGFPL*KKISDL*YFSTKTDCQGPRGSLTGTHE CRHQNWEE*PSQSNFKSVGHSSWWFGVHGNQAE IPERADKRGRL*TV*ISS*FQQQEIWRPLPSS*H QA*VLPRQCQPWSSNP*FPFRLWPARQQTHANA AGPWQSWWSGGHEGSVPFSIS*LCRKIENVSWA EQRPRGRPSSHESTHDLFREG*PEFFTHSLFSQL RNPGLCLSCKYSGSCLWGP*RRFEFSAAL*ETD VPTATRGV*RLEQRFCSGSNCCSTAQAGGATEE SKAAAVS*QSTEPSEK*QRWYDVWPTSGDLP*PQ CPGGWALPNV**WSA*QGHGIKAWLPEVTRILL GSFSANFSSQKQRSSRNVQSKKVWAAP*D*WTW TS*GYTVIQTW*CYAETSRPGGSFFSKPLNHEEA CSFFYLSHSQ*ETVTRCKEQ*H*R*RSPPSLIK RRR**SIQFLCPSFSQSGYQVYP*ERFLQGPSK SR**KLPCCYPHKPC*DQNTAPTERTGIEIGSYS SEDYIPKY*EERIFEQCGGWGRHGYA**YTVFE EWSS*RWECCCSGC*HREEKR*GGFGPSQSSKP GVARRETSSKVFRRVAWQRG*QSEDRDTCRNSYC RKGTPWCHDIHNLTEAW**PRETRWFPGWNSTF NLSRLKECTSSGHIGP*GKPQG*REGERYSDDF TEARGFPSKGIFPIRKEEGETHW*CE*AKETAAA TASTPSAPTDTRRFCRWRAKAKKTEAKEGEKEA WGPAEEAKNQTSSSHCGTPRT*DQTKICHPATG *N*CQEQVFLPLHPCSK*V*TWSRLYNHQC*GRR TDQISEGQEGSEVTDPST*QH*KQGAPGLVLYA AGTCCDRVFGYGAPGLLSVWQVGQLPEHG*PLW TFLSPRLCSHSPEESTS*EGHRNAEQS*GTAQKC F*WLQDGH*GGGRAAAAAEGAEKPGRTPQV*AA PPLGRLWWRPSVPVQGAPL*KSSH*GQQ*KDCF GLEALRAHHFRRWP*AGVTNP*TTS*QQ*ILGP* GLYSLGQWNLPGLWQALWPAGSAGNSQRDEMFP LPGGRRHLGLLQQRLLLPIPLPVCH*CRLFAT* GELLGEVP*AQASPSVPSPPLAEQDRERQPQHRA VGAGVRGAVCSWEWKGQQAQVRLWR*EGGGHS* WNGNRPTVQPHPALPRPAPPACLPMPALP*VLT SHSNQ*HHRKERPKTLEWLFPWTQSP**QCGGRG EGWDDGERVGGIKREG*IYIYKSIFSLERLCLN ERCAIPFDSVLKLSR*RSPNLFR*QVKFKCEIE LNKPSSHEGRGVCVALIFSLSHTSSENTRPRIEK ANHSRTILLSLICLKVGRFWGRGKYRDGPCFQE *GNDV*TQK*IFFHFQKHYLFMVFFF*FFLFGG EIGRCLRS*LCPGSLWLVRTSRTPSSVHSSSKIK G*PSSGAPCPQHIPGSCALTHRDPWGWEEVQAC VARAGSVSCRQGRGGTVAVIRVG*ADQEHPFNP FFFLLSFL*RKRGPVR*AAPCYVILYVVLFCFVN CIIFKYLSFKKRKKYKKILLWP*EGVSASFRGH SAMGIK*LFHKQFYLKKQKTKKIKKSKK**TSF *P

Frame 2

ASDSSLFPPSSRLDFICTKEMRV*CFSFFYF*E GCWPAAVLLNSMQSFREQSSYHGNQQSYPQEVH GSSRLEEFSPRQAQMFQNFGGTGGSSGSSGSGS GGGRRGAAAAAAAMASETSGHQGYQGFRKEAGDF YYMAGNKDPVTTGTPQPPQRRPSGPVQSYGPPQ GSSFGNQYGSEGHVGQFQAQHSGLGGVSHYQQD YTGPFSPGSAQYQQQASSQQQQQQVQQLRQQLYQ SHQPLPQATGQPASSSSHLQPMQRPSTLPSSAA GYQLRVGQFGQHYQSSASSSSSSSFPSPQRFSQ SGQSYDGSYNVNAGSQYEGHNVGSNAQAYGTQSN YSYQPQSMKNFEQAKIPQGTQQGQQQQQPQQQQ HPSQHVMQYTNAATKLPLQSQVGQYNQPEVPVR SPMQFHQNFSPISNPSPAASVVQSPSCSSTPSPL MQTGENLQCGQGSVPMGSRNRILQLMPQLSPTP SMMPSPNSHAAGFKGFGLEGVPEKRLTDPGLSS LSALSTQVANLPNTVQHMLLSDALTPQKKTSKRP SSSKKADSCTNSEGSSQPEEQLKSPMAESLDGG CSSSSEDQGERVRQLSGQSTSSDTTYKGGASEK AGSSPAQGAQNEPPRLNASPAAREEATSPGAKDM PLSSDGNPKVNEKTVGVIVSREAMTGRVEKPGG QDKGSQEDDPAATQRPPSNGGAKETSHASLPQP EPPGGGGSKGNKNGDNNSNHNGEGNGQSGHSAAG PGFTSRTEPSKSPGSLRYSYKDSFGSAVPRNVS GFPQYPTGQEKGDFTGHGERKGRNEKFPSLLQE VLQGYHHHPDRRYSRSTQEHQGMAGSLEGTTRPN VLVSQTNELASRGLLNKSIGSLLENPHWGPWER KSSSTAPEMKQINLTDYPIPRKFEIEPQSSAHE PGGSLSERRSVICDISPLRQIVRDPGAHSLGHMS ADTRIGRNDRLNPTLSQSVILPGGLVSMETKLK SQSGQIKEEDFEQSKSQASFNNKKSGDHCHPPS IKHESYRGNASPGAATHDSLSDYGPQDSRPTPMR RVPGRVGGREGMRGRSPSQYHDFAEKLKMSPGR SRGPGGDPHHMNPHMTFSERANRSSLHTPFSPN SETLASAYHANTRAHAYGDPNAGLNSQLHYKRQM YQQQPEEYKDWSSGSAQGVIAAAQHRQEGPRKS PRQQQFLDRVRSPLKNDKDGMMYGPPVGTYHDP SAQEAGRCLMSSDGLPNKGMELKHGSQKLQESCW DLSRQTSPAKSSGPPGMSSQKRYGPPHETDGHG LAEATQSSKPGSVMLRLPGQEDHSSQNPLIMRR RVRSFISPIPSKRQSQDVKNSSTEDKGRLLHSSK EGADKAFNSYAHLSHSQDIKSIPKRDSSKDLPS PDSRNCPAVTLTSPAKTKILPPRKGRGLKLEAI VQKITSPNIRRSASSNSAEAGGDTVTLDDILSLK SGPPEGGSVAVQDADIEKRKGEVASDLVSPANQ ELHVEKPLPRSSEEWRGSVDDKVKTETHAETVT AGKEPPGAMTSTTSQKPGSNQGRPDGSLGGTAPL IFPDSKNVPPVGILAPEANPKAEEKENDTVTIS PKQEGFPPKGYFPSGKKKGRPIGSVNKQKKQQQ PPPPPPQPPQIPEGSADGEPKPKKQRQRRERRKP GAQPRKRKTKQAVPIVEPQEPEIKLKYATQPLD KTDAKNKSFYPYIHVVNKCELGAVCTIINAEEE EQTKLVRGRKGQRSLTPPPSSTESKALPASSFML QGPVVTESSVMGHLVCCLCGKWASYRNMGDLFG PFYPQDYAATLPKNPPPKRATEMQSKVKVRHKS ASNGSKTDTEEEEEQQQQQKEQRSLAAHPRFKRR HRSEDCGGGPRSLSRGLPCKKAATEGSSEKTVL DSKPSVPTTSEGGPELELQIPELPLDSNEFWVH EGCILWANGIYLVCGRLYGLQEALEIAREMKCSH CQEAGATLGCYNKGCSFRYHYPCAIDADCLLHE ENFSVRCPKHKPPLPCPLPPLQNKTAKGSLSTE QSERG*GGQCARGNGKDSKHR*DCGDEKVVDTRD GMEIVLPCSHTLPCPAPPRPRACPCQHFLKFSH HTQTSDTTGKKDPRRWNGCFHGHNLHSDNVGGG GRGGMMGKGWGELKGRDKYIYINLFLVWKDFV*M KGALSLLILF*NYLVKDLQICSDDK*NLNVRLN *TNPHLMKDGVCVWR*SLACLTPVQKTLDPGLK KQTTAEPSFCH*FVSKWEGFGGGGNTGMVHVFKS RGMMFKHKNKFFFISRNTIYLWFFFFNFFFLGV KLADA*GHSCVLGHCGW*GPQGPHQVYTAAAKS RDDPPLGPPVLSTFQAAVP*PTGTRGDGRRSRPV LPELAV*AVGRDGEGLSL*SEWVKLTRNTHLTP FSFCFHFYKGKEDLSDRQPHAT*FFMLCCFVL* IV*FLNI*VLKKEKSTKKSCYGLKKGLVHLSGVT LPWG*NSCFTNSFI*KNKKQKKSKNQKNNKLHF NL