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Sequences

Sequence NM_199438

AGCCCTCCCAGGTGTGGGACAGAAGGGGCAGAGGGAGGGCAGAGGCTTAAAGGCTGTGAGCAGTCAGATCAAAAATGAAGCCAGCTCTTCCTCACAGCCG GTAGATGGAAGTCATTTTTCCAGGGCCTGGAAGGAGTTGGTAGGAAGACTAGATTTCAGCCAGCCCTTGCGCCCTGTTTGTGCCAGCAGGCACCAGCGAA CCAAAAGCAGGTGTCCATGTCTGCTTACTCTGTGCCTTCAACTTTTGCCCAGGCCTCATTGCCAGTTCATAACCAGGTGCTGCCTTCCATCGAGAGTGTA GATGGGTCCGACCCTTTGGCAACTCTGCAGACCCCTCTAGGCAGACTGGAGGCCAAAGAGGAAGAGGATGAGGATGAGGACGAGGACACTGAGGAAGATG AGGAAGAAGACGGTGAGGACACGGATCTGGATGACTGGGAGCCAGACCCGCCCCGGCCCTTCGACCCACACGACTTGTGGTGTGAGGAGTGCAATAACGC GCATGCTTCAGTGTGTCCGAAGCACGGCCCCTTGCACCCGATCCCCAACCGGCCGGTGCTCACCCGGGCCAGGGCGAGCCTCCCCCTGGTGCTCTACATA GACAGGTTTCTGGGCGGGGTGTTCTCCAAGCGGCGCATCCCCAAGCGCACCCAGTTTGGCCCCGTGGAGGGGCCTCTCGTCAGGGGCTCGGAGCTGAAAG ACTGTTACATTCACCTCAAGGTTTCTCTTGATAAAGGGGACAGGAAAGAAAGGGATTTACATGAAGACCTATGGTTTGAGTTGTCTGATGAGACGCTTTG TAACTGGATGATGTTTGTACGGCCAGCCCAGAATCACCTGGAGCAGAACCTGGTGGCTTACCAGTATGGCCACCATGTGTATTATACAACCATAAAAAAT GTGGAGCCCAAGCAGGAACTGAAGGTGTGGTATGCCGCATCCTATGCTGAGTTCGTGAACCAGAAAATTCATGACATTTCTGAGGAAGAAAGGAAAGTTC TTCGAGAGCAAGAGAAGAATTGGCCCTGCTATGAATGTAACCGCCGATTTATAAGCTCGGAGCAGTTGCAACAGCATCTCAATTCTCATGATGAGAAACT AGATGTGTTTAGCAGAACAAGAGGCAGAGGAAGGGGACGAGGCAAGAGGCGATTCGGTCCAGGTCGACGGCCGGGGCGTCCTCCAAAATTTATCCGCCTG GAAATCACCAGCGAAAATGGGGAAAAGAGTGACGATGGGACACAGGACTTGCTACATTTTCCCACAAAGGAGCAATTTGATGAGGCTGAACCAGCCACTC TGAATGGGCTGGATCAACCAGAACAGACCACTATCCCAATCCCTCAGCTGCCACAGGAAACCCAGTCTTCCCTGGAACATGAACCAGAAACTCACACCCT GCACCTGCAGCCGCAGCATGAAGAGAGCGTGGTGCCCACCCAGAGCACGCTGACAGCCGACGACATGCGCAGAGCCAAGCGCATCCGATTGGAGCTGCAG AATGCAGCTCTTCAGCATCTGTTTATTCGGAAGTCCTTCCGGCCTTTTAAATGCTTGCAGTGTGGGAAGGCCTTCCGGGAAAAGGACAAACTGGACCAGC ACTTACGCTTCCATGGGCGGGAGGGGAACTGCCCACTGACCTGTGATCTCTGTAACAAGGGCTTCATCAGCAGCACATCCTTGGAGAGCCACATGAAGCT CCACTCAGACCAGAAGACTTACTCTTGCATTTTTTGCCCAGAATCCTTTGACCGCCTTGATTTGTTGAAAGATCATGTGGCCATTCATATCAATGATGGC TACTTCACCTGCCCAACTTGTAAGAAACGGTTCCCAGATTTTATCCAGGTGAAAAAACACGTGCGCAGCTTCCACTCAGAAAAGATCTACCAGTGCACAG AGTGTGACAAGGCCTTCTGTCGCCCCGATAAACTGCGACTCCACATGCTCCGGCATTCGGACCGCAAAGACTTCCTGTGTTCCACCTGTGGGAAGCAATT TAAGCGAAAAGACAAACTACGGGAACACATGCAGAGGATGCATAATCCTGAGAGGGAGGCCAAGAAAGCCGACCGCATCAGCCGCTCCAAGACGTTCAAG CCCCGCATCACGTCCACAGACTACGACAGCTTCACGTTCAAGTGCCGCCTGTGCATGATGGGCTTCCGGCGGCGCGGCATGCTGGTAAATCACTTATCGA AGAGACACCCAGACATGAAGATAGAAGAGGTGCCAGAGTTAACTCTACCCATCATAAAACCCAATCGTGATTACTTTTGTCAGTATTGCGATAAGGTTTA TAAAAGTGCCAGCAAGCGCAAAGCCCACATTCTGAAGAACCACCCAGGAGCAGAGCTCCCACCGAGCATTCGGAAGCTCCGACCCGCTGGTCCTGGAGAG CCAGACCCCATGCTGAGCACACACACCCAGCTGACGGGCACCATCGCCACCCCTCCCGTCTGCTGTCCCCACTGCTCCAAGCAGTACAGCAGCAAGACCA AGATGGTCCAGCACATTCGAAAGAAGCATCCAGAGTTCGCCCAGCTCTCCAACACCATACACACACCACTGACGACAGCTGTGATCAGTGCCACCCCAGC GGTTTTGACTACAGACAGCGCCACTGGAGAGACTGTGGTGACGACGGACCTGCTCACCCAAGCAATGACAGAACTGTCCCAGACCTTAACGACAGACTAC CGAACGCCACAAGGGGATTACCAGAGAATTCAGTACATCCCTGTGTCGCAGTCGGCGTCTGGCCTCCAGCAGCCTCAGCACATACAGCTGCAAGTGGTTC AAGTGGCCTCGGCCACTTCCCCTCACCAGTCACAGCAGTCCACTGTGGATGTTGGCCAGCTCCATGATCCTCAGCCCTACCCCCAGCACGCCATCCAGGT GCAGCACATCCAGGTATCTGGGCAGCCGTTGAGTCCCTCAGCCCAGCAGGCTCAGCAGGGGCTCAGCCCCTCCCACATCCAGGGCAGTTCTTCCACACAG GGGCAGGCTCTGCAGCAGCAGCAGCAGCAGCAGCAGAATTCCTCTGTGCAGCACACGTACCTGCCCAGTGCTTGGAATTCCTTCCGTGGCTATTCATCTG AGATTCAAATGATGACGCTTCCTCCGGGTCAGTTTGTGATTACAGACAGTGGTGTGGCAACTCCAGTTACTACTGGCCAGGTGAAGGCGGTTACTTCGGG TCATTATGTGTTATCAGAAAGTCAATCAGAATTGGAAGAAAAGCAAACTTCTGCCCTCTCTGGTGGAGTCCAGGTCGAGCCACCTGCACACAGTGACTCC CTGGACCCCCAGACCAACAGCCAACAGCAGACCACACAGTACATCATCACCACCACCACCAACGGGAACGGAAGCAGCGAAGTGCATATCACCAAACCAT GACTTCCACCCTGGAGCTTGAATCCAGCACCCACCTCATGTCTGTTCTCATAAGTCTGAAAGCTCTGACACGTAGAGCTCTTTTGTAAGATTTATTATTC ACTCAAGAGTTCGGAAACCACAGTTTTGTCTCTCATCCATACACTGGGGTTTATTTTGCCAAGGTCATCTTTATCAAATTGACTCTTCAAACCCTCGGTT TTTGCCACAGAACAGAGATCTTTCAGGGGAAAGTAGATTTCGAGGTGGAGAGAATTTGCCTTGCTCTTGAGCTGGTCTTTTAACATACTGACGAGCCTTA CTTTTCCTTTGTGGAAATATTAAGTGGCATATTGTGTTCATACCAAAGGTGGAGACAGGATGTGCCAAGTTCATGGTTACTGGACTTCTTATTCCAAGCC ATGGCACCAAAGGAGAAGGGGCATTTTGTGGGTGTGCATTAGGTCTGAACTGCTTTATCTTGTTTTAGTTTTCAGTAATTTAACAAAGGGAGCCTGCTGA ATAACAAAATTAAAATGATGAAACAAAAGTTTGACAGTGATATTCTGAAGCAAAAACTGTCATCTAAATTTTTCTTGCTGATTTTTTTTAACTTCCCTAT TTTAGAAAACTATTGTTGGGCTGTTGGTAGTGCTTTCCACAGATGCTGGTCCTCAGTGGATTAGGTCAGAAGCTCATGTTCTGATAGTTCTTCATTATTT CACAAAGGTGGACAACCTGAAAGAGAAAAGGCTGCTTGATGTCAGCAGAATCTAAACCCCTACATTAAAGCTTTGCCTCCCATTCTGTGGTTGTGGTGGT GGTAAGAAGGAGATATTGGTACCAAGAAAAATTTCCAAAACTATTGAGAGAGAGAGAGAGAAAGTATTGAAATTTTGTTCTGCCTTGCAGGATCCATTTA TCATTCATTGGTAAAGGATATATTCCTTGTTCTTACCAAGTGTACATTTAACTCTTGCTGACATGTTCAGTGTATTTTATTACTTTTAATGCTGTCTTAA AATGAACATTCTTTAAAGTTGGACAGGAAGGTGGCATTTCTTATTTATTAACATTTTTAACTTTAAACATATTGTGACTCATCTAGACCTTTTAATAAGA CGGTCAACTTCACACTTAGGGAAAAAATTAAAATGTGATGGCCACTTCTAATAATTCAGGTAGTTATAAGGGATCTGGAAGAAATCCAGTCTTTATGAAT ATACTATTAGTTGGGCATTAAAAAATCAGTATATATTTTAACTTTTTGTGACATGCTAACACATTTTCAGAATAATTATTGCATAGTAGAATTTATTACT CCAGAACAGAAAGACCTTACTTCATTTCAAATGAAGTTAATTAATTTACATTTCTGGGTAAAAACTGGTTCTATAAATTAAGTAGAGTAGCTTCTTTATG ATAAAGACAATTTTCTGAAAAGTGAACAATTCTGTTAAAAGAACTTTATTGATGTGTAGATTTCGCACTTTATTTCTGAGACTGCGTTCATGTAGTTGTT CCCCAATGTTTGAGTACTAAGAGAACTTGAGAAAATTACTTCATAAACATATGGAAACTGAAAATGGACTCTCTTTGTGACAAAGATATTCAACAGAAAA TATTGACCCTGCATTGCAAAACACAGGTTCGGGTTCCCTAAGTCCCACAGTGTAATGATTACAAATATCCTAGTGTCCGGTCTAGAAAGACTTTCTAGGA GAAGACTAGTGGAATTTTCTAAAGGTTCAGTTTTAGCTTTTATAACTTAAATTTGGCCCTGTTACGTTCTTTTTAATTTGAACCATAAGGTATCTCCCCT CCCTTCAGGAATAACTTATTGGAAAACTGAAAAGAATCACTGAATGGAATGTTCATTTTATGGCAGTTGTTTTAAGTTTTAAAATACACAGAGGAAAATA TTGTGGAAGGACCTCTTTGTTGCTTTCCCTTCTAAGTTGTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTTGGTCCTTAAGTGAAATAAAGACTCTAAAA CTAATTTGTATATTATCAGCCAGAGATGCGGATGGCAGTCGAGCCAAATCGCATGGCTTTCAGATCAGGTATTCTGCACATTCATTCCAAGGTCATAGAT TTTTAAAAGGACCTGGATTTGAAGAGATGGCAAATGATGAGCCATCAGAAAACTTAATTTGGAAAACATGTATGTAGCCAGTGTGGATATTGTGGCCTCT CTCAAGACACATTGACACTGTAGACTTCATTCAGTCCAGTGTGAGTATTTTGGAGTAGGTTGGATGTAGATTTTGTTTTTATCATTGATTTGTACCGACA GAAATAGACATTTCATCATGTAAAATTCCTGTTATTCTGGAAAAACCTATTGTTTTGATCTTCTTGTTTTCTGACTTGGAAGTATCCTTTCAAAAAAACT CTTAAGATATCTAGGTCTAAAAAGCACTTCATGAGATGCTAAAGCTGACCCACTGGTTGAAAATGTTGACCCTATCCTGTTATTTAAATGTGAACATTTA TTGTACATTCAGTGAGTTATAGTGTTAATAGTCTTGTGCTATGCAGCAGGTGTAAAAATTAATAAATATATTTTTTAATAAACATGTTTGTATGTGTGAA GCTACAAGA

refseq_PRDM10.F1 (forward primer)
refseq_PRDM10.R1 (reverse primer)
Alternative donor

Frame 0

SPPRCGTEGAEGGQRLKGCEQSDQK*SQLFLTA GRWKSFFQGLEGVGRKTRFQPALAPCLCQQAPAN QKQVSMSAYSVPSTFAQASLPVHNQVLPSIESV DGSDPLATLQTPLGRLEAKEEEDEDEDEDTEED EEEDGEDTDLDDWEPDPPRPFDPHDLWCEECNNA HASVCPKHGPLHPIPNRPVLTRARASLPLVLYI DRFLGGVFSKRRIPKRTQFGPVEGPLVRGSELK DCYIHLKVSLDKGDRKERDLHEDLWFELSDETLC NWMMFVRPAQNHLEQNLVAYQYGHHVYYTTIKN VEPKQELKVWYAASYAEFVNQKIHDISEEERKV LREQEKNWPCYECNRRFISSEQLQQHLNSHDEKL DVFSRTRGRGRGRGKRRFGPGRRPGRPPKFIRL EITSENGEKSDDGTQDLLHFPTKEQFDEAEPAT LNGLDQPEQTTIPIPQLPQETQSSLEHEPETHTL HLQPQHEESVVPTQSTLTADDMRRAKRIRLELQ NAALQHLFIRKSFRPFKCLQCGKAFREKDKLDQ HLRFHGREGNCPLTCDLCNKGFISSTSLESHMKL HSDQKTYSCIFCPESFDRLDLLKDHVAIHINDG YFTCPTCKKRFPDFIQVKKHVRSFHSEKIYQCT ECDKAFCRPDKLRLHMLRHSDRKDFLCSTCGKQF KRKDKLREHMQRMHNPEREAKKADRISRSKTFK PRITSTDYDSFTFKCRLCMMGFRRRGMLVNHLS KRHPDMKIEEVPELTLPIIKPNRDYFCQYCDKVY KSASKRKAHILKNHPGAELPPSIRKLRPAGPGE PDPMLSTHTQLTGTIATPPVCCPHCSKQYSSKT KMVQHIRKKHPEFAQLSNTIHTPLTTAVISATPA VLTTDSATGETVVTTDLLTQAMTELSQTLTTDY RTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVV QVASATSPHQSQQSTVDVGQLHDPQPYPQHAIQV QHIQVSGQPLSPSAQQAQQGLSPSHIQGSSSTQ GQALQQQQQQQQNSSVQHTYLPSAWNSFRGYSS EIQMMTLPPGQFVITDSGVATPVTTGQVKAVTSG HYVLSESQSELEEKQTSALSGGVQVEPPAHSDS LDPQTNSQQQTTQYIITTTTNGNGSSEVHITKP *LPPWSLNPAPTSCLFS*V*KL*HVELFCKIYYS LKSSETTVLSLIHTLGFILPRSSLSN*LFKPSV FATEQRSFRGK*ISRWREFALLLSWSFNILTSL TFPLWKY*VAYCVHTKGGDRMCQVHGYWTSYSKP WHQRRRGILWVCIRSELLYLVLVFSNLTKGAC* ITKLK**NKSLTVIF*SKNCHLNFSC*FFLTSL F*KTIVGLLVVLSTDAGPQWIRSEAHVLIVLHYF TKVDNLKEKRLLDVSRI*TPTLKLCLPFCGCGG GKKEILVPRKISKTIEREREKVLKFCSALQDPF IIHW*RIYSLFLPSVHLTLADMFSVFYYF*CCLK MNIL*SWTGRWHFLFINIFNFKHIVTHLDLLIR RSTSHLGKKLKCDGHF**FR*L*GIWKKSSLYE YTISWALKNQYIF*LFVTC*HIFRIIIA**NLLL QNRKTLLHFK*S*LIYISG*KLVL*IK*SSFFM IKTIF*KVNNSVKRTLLMCRFRTLFLRLRSCSC SPMFEY*ENLRKLLHKHMETENGLSL*QRYSTEN IDPALQNTGSGSLSPTV**LQIS*CPV*KDFLG ED*WNFLKVQF*LL*LKFGPVTFFLI*TIRYLP SLQE*LIGKLKRITEWNVHFMAVVLSFKIHRGKY CGRTSLLLSLLSCLLLLLLLLLLWSLSEIKTLK LICILSARDADGSRAKSHGFQIRYSAHSFQGHR FLKGPGFEEMANDEPSENLIWKTCM*PVWILWPL SRHIDTVDFIQSSVSILE*VGCRFCFYH*FVPT EIDISSCKIPVILEKPIVLIFLFSDLEVSFQKN S*DI*V*KALHEMLKLTHWLKMLTLSCYLNVNIY CTFSEL*C**SCAMQQV*KLINIFFNKHVCMCE ATR

Frame 1

ALPGVGQKGQREGRGLKAVSSQIKNEASSSSQP VDGSHFSRAWKELVGRLDFSQPLRPVCASRHQR TKSRCPCLLTLCLQLLPRPHCQFITRCCLPSRV* MGPTLWQLCRPL*ADWRPKRKRMRMRTRTLRKM RKKTVRTRIWMTGSQTRPGPSTHTTCGVRSAIT RMLQCVRSTAPCTRSPTGRCSPGPGRASPWCST* TGFWAGCSPSGASPSAPSLAPWRGLSSGARS*K TVTFTSRFLLIKGTGKKGIYMKTYGLSCLMRRF VTG*CLYGQPRITWSRTWWLTSMATMCIIQP*KM WSPSRN*RCGMPHPMLSS*TRKFMTFLRKKGKF FESKRRIGPAMNVTADL*ARSSCNSISILMMRN *MCLAEQEAEEGDEARGDSVQVDGRGVLQNLSAW KSPAKMGKRVTMGHRTCYIFPQRSNLMRLNQPL *MGWINQNRPLSQSLSCHRKPSLPWNMNQKLTP CTCSRSMKRAWCPPRAR*QPTTCAEPSASDWSCR MQLFSICLFGSPSGLLNACSVGRPSGKRTNWTS TYASMGGRGTAH*PVISVTRASSAAHPWRAT*S STQTRRLTLAFFAQNPLTALIC*KIMWPFISMMA TSPAQLVRNGSQILSR*KNTCAASTQKRSTSAQ SVTRPSVAPINCDSTCSGIRTAKTSCVPPVGSN LSEKTNYGNTCRGCIILRGRPRKPTASAAPRRSS PASRPQTTTASRSSAACA*WASGGAACW*ITYR RDTQT*R*KRCQS*LYPS*NPIVITFVSIAIRF IKVPASAKPTF*RTTQEQSSHRAFGSSDPLVLES QTPC*AHTPS*RAPSPPLPSAVPTAPSSTAARP RWSSTFERSIQSSPSSPTPYTHH*RQL*SVPPQ RF*LQTAPLERLW*RRTCSPKQ*QNCPRP*RQTT ERHKGITREFSTSLCRSRRLASSSLSTYSCKWF KWPRPLPLTSHSSPLWMLASSMILSPTPSTPSR CSTSRYLGSR*VPQPSRLSRGSAPPTSRAVLPHR GRLCSSSSSSSRIPLCSTRTCPVLGIPSVAIHL RFK**RFLRVSL*LQTVVWQLQLLLAR*RRLLR VIMCYQKVNQNWKKSKLLPSLVESRSSHLHTVTP WTPRPTANSRPHSTSSPPPPTGTEAAKCISPNH DFHPGA*IQHPPHVCSHKSESSDT*SSFVRFII HSRVRKPQFCLSSIHWGLFCQGHLYQIDSSNPRF LPQNRDLSGESRFRGGENLPCS*AGLLTY*RAL LFLCGNIKWHIVFIPKVETGCAKFMVTGLLIPS HGTKGEGAFCGCALGLNCFILF*FSVI*QREPAE *QN*NDETKV*Q*YSEAKTVI*IFLADFF*LPY FRKLLLGCW*CFPQMLVLSGLGQKLMF**FFII SQRWTT*KRKGCLMSAESKPLH*SFASHSVVVVV VRRRYWYQEKFPKLLRERERKY*NFVLPCRIHL SFIGKGYIPCSYQVYI*LLLTCSVYFITFNAVL K*TFFKVGQEGGISYLLTFLTLNIL*LI*TF**D GQLHT*GKN*NVMATSNNSGSYKGSGRNPVFMN ILLVGH*KISIYFNFL*HANTFSE*LLHSRIYY SRTERPYFISNEVN*FTFLGKNWFYKLSRVASL* *RQFSEK*TILLKELY*CVDFALYF*DCVHVVV PQCLSTKRT*ENYFINIWKLKMDSLCDKDIQQK ILTLHCKTQVRVP*VPQCNDYKYPSVRSRKTF*E KTSGIF*RFSFSFYNLNLALLRSF*FEP*GISP PFRNNLLEN*KESLNGMFILWQLF*VLKYTEEN IVEGPLCCFPF*VVFFFFFFFFFFGP*VK*RL*N *FVYYQPEMRMAVEPNRMAFRSGILHIHSKVID F*KDLDLKRWQMMSHQKT*FGKHVCSQCGYCGL SQDTLTL*TSFSPV*VFWSRLDVDFVFIIDLYRQ K*TFHHVKFLLFWKNLLF*SSCFLTWKYPFKKT LKISRSKKHFMRC*S*PTG*KC*PYPVI*M*TF IVHSVSYSVNSLVLCSRCKN**IYFLINMFVCVK LQ

Frame 2

PSQVWDRRGRGRAEA*RL*AVRSKMKPALPHSR *MEVIFPGPGRSW*ED*ISASPCALFVPAGTSE PKAGVHVCLLCAFNFCPGLIASS*PGAAFHREC RWVRPFGNSADPSRQTGGQRGRG*G*GRGH*GR* GRRR*GHGSG*LGARPAPALRPTRLVV*GVQ*R ACFSVSEARPLAPDPQPAGAHPGQGEPPPGALH RQVSGRGVLQAAHPQAHPVWPRGGASRQGLGAER LLHSPQGFS**RGQERKGFT*RPMV*VV**DAL *LDDVCTASPESPGAEPGGLPVWPPCVLYNHKK CGAQAGTEGVVCRILC*VREPENS*HF*GRKESS SRAREELALL*M*PPIYKLGAVATASQFS**ET RCV*QNKRQRKGTRQEAIRSRSTAGASSKIYPP GNHQRKWGKE*RWDTGLATFSHKGAI**G*TSHS EWAGSTRTDHYPNPSAATGNPVFPGT*TRNSHP APAAAA*RERGAHPEHADSRRHAQSQAHPIGAA ECSSSASVYSEVLPAF*MLAVWEGLPGKGQTGPA LTLPWAGGELPTDL*SL*QGLHQQHILGEPHEA PLRPEDLLLHFLPRIL*PP*FVERSCGHSYQ*W LLHLPNL*ETVPRFYPGEKTRAQLPLRKDLPVHR V*QGLLSPR*TATPHAPAFGPQRLPVFHLWEAI *AKRQTTGTHAEDA*S*EGGQESRPHQPLQDVQ APHHVHRLRQLHVQVPPVHDGLPAARHAGKSLIE ETPRHEDRRGARVNSTHHKTQS*LLLSVLR*GL *KCQQAQSPHSEEPPRSRAPTEHSEAPTRWSWR ARPHAEHTHPADGHHRHPSRLLSPLLQAVQQQDQ DGPAHSKEASRVRPALQHHTHTTDDSCDQCHPS GFDYRQRHWRDCGDDGPAHPSNDRTVPDLNDRL PNATRGLPENSVHPCVAVGVWPPAASAHTAASGS SGLGHFPSPVTAVHCGCWPAP*SSALPPARHPG AAHPGIWAAVESLSPAGSAGAQPLPHPGQFFHT GAGSAAAAAAAAEFLCAAHVPAQCLEFLPWLFI* DSNDDASSGSVCDYRQWCGNSSYYWPGEGGYFG SLCVIRKSIRIGRKANFCPLWWSPGRATCTQ*L PGPPDQQPTADHTVHHHHHHQRERKQRSAYHQTM TSTLELESSTHLMSVLISLKALTRRALL*DLLF TQEFGNHSFVSHPYTGVYFAKVIFIKLTLQTLG FCHRTEIFQGKVDFEVERICLALELVF*HTDEPY FSFVEILSGILCSYQRWRQDVPSSWLLDFLFQA MAPKEKGHFVGVH*V*TALSCFSFQ*FNKGSLL NNKIKMMKQKFDSDILKQKLSSKFFLLIFFNFPI LENYCWAVGSAFHRCWSSVD*VRSSCSDSSSLF HKGGQPEREKAA*CQQNLNPYIKALPPILWLWW W*EGDIGTKKNFQNY*ERERESIEILFCLAGSIY HSLVKDIFLVLTKCTFNSC*HVQCILLLLMLS* NEHSLKLDRKVAFLIY*HF*L*TYCDSSRPFNK TVNFTLREKIKM*WPLLIIQVVIRDLEEIQSL*I YY*LGIKKSVYILTFCDMLTHFQNNYCIVEFIT PEQKDLTSFQMKLINLHFWVKTGSIN*VE*LLY DKDNFLKSEQFC*KNFIDV*ISHFISETAFM*LF PNV*VLRELEKITS*TYGN*KWTLFVTKIFNRK Y*PCIAKHRFGFPKSHSVMITNILVSGLERLSR RRLVEFSKGSVLAFIT*IWPCYVLFNLNHKVSPL PSGITYWKTEKNH*MECSFYGSCFKF*NTQRKI LWKDLFVAFPSKLSSSSSSSSSSLVLK*NKDSK TNLYIISQRCGWQSSQIAWLSDQVFCTFIPRS*I FKRTWI*RDGK**AIRKLNLENMYVASVDIVAS LKTH*HCRLHSVQCEYFGVGWM*ILFLSLICTD RNRHFIM*NSCYSGKTYCFDLLVF*LGSILSKKL LRYLGLKSTS*DAKADPLVENVDPILLFKCEHL LYIQ*VIVLIVLCYAAGVKINKYIF**TCLYV* SYK

Sequence NM_199437

ACTCTGCGGCGGGAAGAACCACCTGGAGGTGGCGGGGGGGGTTGATTTCTATCACCCCTAGGGAGAGAGGATCGGGGACCCGCTGATCTTCCAGCTCCCC TCACCCAACGTCGTGCATGCTGCAGACAGACCTTTCCGTCCTTCATGAACACACGTGTGGTAGACAGATGACTGTCCTGTACCCTGTGCTGCTCTAGGTG TGCCAGACGTGGAGCTGTCCAGTTGGGAGAAGATGGATTCCAAAGATGAAAGCTCGCATGTGTGGCCGACATCTGCAGAGCATGAACAGAATGCCGCACA GGTGCACTTTGTTCCGGACACAGGAACAGTGGCTCAGATTGTCTATACCGATGACCAGGTTCGCCCCCCACAGCAGGTGGTGTACACGGCAGATGGTGCC TCCTACACATCAGTGGATGGTCCAGAGCACACGCTGGTGTACATCCACCCGGTGGAAGCTGCACAGACTCTGTTTACAGACCCCGGCCAGGTAGCTTATG TCCAACAGGATGCTACAGCTCAGCAGGCCTCATTGCCAGTTCATAACCAGGTGCTGCCTTCCATCGAGAGTGTAGATGGGTCCGACCCTTTGGCAACTCT GCAGACCCCTCTAGGCAGACTGGAGGCCAAAGAGGAAGAGGATGAGGATGAGGACGAGGACACTGAGGAAGATGAGGAAGAAGACGGTGAGGACACGGAT CTGGATGACTGGGAGCCAGACCCGCCCCGGCCCTTCGACCCACACGACTTGTGGTGTGAGGAGTGCAATAACGCGCATGCTTCAGTGTGTCCGAAGCACG GCCCCTTGCACCCGATCCCCAACCGGCCGGTGCTCACCCGGGCCAGGGCGAGCCTCCCCCTGGTGCTCTACATAGACAGGTTTCTGGGCGGGGTGTTCTC CAAGCGGCGCATCCCCAAGCGCACCCAGTTTGGCCCCGTGGAGGGGCCTCTCGTCAGGGGCTCGGAGCTGAAAGACTGTTACATTCACCTCAAGGTTTCT CTTGATAAAGGGGACAGGAAAGAAAGGGATTTACATGAAGACCTATGGTTTGAGTTGTCTGATGAGACGCTTTGTAACTGGATGATGTTTGTACGGCCAG CCCAGAATCACCTGGAGCAGAACCTGGTGGCTTACCAGTATGGCCACCATGTGTATTATACAACCATAAAAAATGTGGAGCCCAAGCAGGAACTGAAGGT GTGGTATGCCGCATCCTATGCTGAGTTCGTGAACCAGAAAATTCATGACATTTCTGAGGAAGAAAGGAAAGTTCTTCGAGAGCAAGAGAAGAATTGGCCC TGCTATGAATGTAACCGCCGATTTATAAGCTCGGAGCAGTTGCAACAGCATCTCAATTCTCATGATGAGAAACTAGATGTGTTTAGCAGAACAAGAGGCA GAGGAAGGGGACGAGGCAAGAGGCGATTCGGTCCAGGTCGACGGCCGGGGCGTCCTCCAAAATTTATCCGCCTGGAAATCACCAGCGAAAATGGGGAAAA GAGTGACGATGGGACACAGGACTTGCTACATTTTCCCACAAAGGAGCAATTTGATGAGGCTGAACCAGCCACTCTGAATGGGCTGGATCAACCAGAACAG ACCACTATCCCAATCCCTCAGCTGCCACAGGAAACCCAGTCTTCCCTGGAACATGAACCAGAAACTCACACCCTGCACCTGCAGCCGCAGCATGAAGAGA GCGTGGTGCCCACCCAGAGCACGCTGACAGCCGACGACATGCGCAGAGCCAAGCGCATCCGAAATGCAGCTCTTCAGCATCTGTTTATTCGGAAGTCCTT CCGGCCTTTTAAATGCTTGCAGTGTGGGAAGGCCTTCCGGGAAAAGGACAAACTGGACCAGCACTTACGCTTCCATGGGCGGGAGGGGAACTGCCCACTG ACCTGTGATCTCTGTAACAAGGGCTTCATCAGCAGCACATCCTTGGAGAGCCACATGAAGCTCCACTCAGACCAGAAGACTTACTCTTGCATTTTTTGCC CAGAATCCTTTGACCGCCTTGATTTGTTGAAAGATCATGTGGCCATTCATATCAATGATGGCTACTTCACCTGCCCAACTTGTAAGAAACGGTTCCCAGA TTTTATCCAGGTGAAAAAACACGTGCGCAGCTTCCACTCAGAAAAGATCTACCAGTGCACAGAGTGTGACAAGGCCTTCTGTCGCCCCGATAAACTGCGA CTCCACATGCTCCGGCATTCGGACCGCAAAGACTTCCTGTGTTCCACCTGTGGGAAGCAATTTAAGCGAAAAGACAAACTACGGGAACACATGCAGAGGA TGCATAATCCTGAGAGGGAGGCCAAGAAAGCCGACCGCATCAGCCGCTCCAAGACGTTCAAGCCCCGCATCACGTCCACAGACTACGACAGCTTCACGTT CAAGTGCCGCCTGTGCATGATGGGCTTCCGGCGGCGCGGCATGCTGGTAAATCACTTATCGAAGAGACACCCAGACATGAAGATAGAAGAGGTGCCAGAG TTAACTCTACCCATCATAAAACCCAATCGTGATTACTTTTGTCAGTATTGCGATAAGGTTTATAAAAGTGCCAGCAAGCGCAAAGCCCACATTCTGAAGA ACCACCCAGGAGCAGAGCTCCCACCGAGCATTCGGAAGCTCCGACCCGCTGGTCCTGGAGAGCCAGACCCCATGCTGAGCACACACACCCAGCTGACGGG CACCATCGCCACCCCTCCCGTCTGCTGTCCCCACTGCTCCAAGCAGTACAGCAGCAAGACCAAGATGGTCCAGCACATTCGAAAGAAGCATCCAGAGTTC GCCCAGCTCTCCAACACCATACACACACCACTGACGACAGCTGTGATCAGTGCCACCCCAGCGGTTTTGACTACAGACAGCGCCACTGGAGAGACTGTGG TGACGACGGACCTGCTCACCCAAGCAATGACAGAACTGTCCCAGACCTTAACGACAGACTACCGAACGCCACAAGGGGATTACCAGAGAATTCAGTACAT CCCTGTGTCGCAGTCGGCGTCTGGCCTCCAGCAGCCTCAGCACATACAGCTGCAAGTGGTTCAAGTGGCCTCGGCCACTTCCCCTCACCAGTCACAGCAG TCCACTGTGGATGTTGGCCAGCTCCATGATCCTCAGCCCTACCCCCAGCACGCCATCCAGGTGCAGCACATCCAGGTCAGCGAGCCTACCGCCTCGGCCC CGTCCTCCGCCCAGGTATCTGGGCAGCCGTTGAGTCCCTCAGCCCAGCAGGCTCAGCAGGGGCTCAGCCCCTCCCACATCCAGGGCAGTTCTTCCACACA GGGGCAGGCTCTGCAGCAGCAGCAGCAGCAGCAGCAGAATTCCTCTGTGCAGCACACGTACCTGCCCAGTGCTTGGAATTCCTTCCGTGGCTATTCATCT GAGATTCAAATGATGACGCTTCCTCCGGGTCAGTTTGTGATTACAGACAGTGGTGTGGCAACTCCAGTTACTACTGGCCAGGTGAAGGCGGTTACTTCGG GTCATTATGTGTTATCAGAAAGTCAATCAGAATTGGAAGAAAAGCAAACTTCTGCCCTCTCTGGTGGAGTCCAGGTCGAGCCACCTGCACACAGTGACTC CCTGGACCCCCAGACCAACAGCCAACAGCAGACCACACAGTACATCATCACCACCACCACCAACGGGAACGGAAGCAGCGAAGTGCATATCACCAAACCA TGACTTCCACCCTGGAGCTTGAATCCAGCACCCACCTCATGTCTGTTCTCATAAGTCTGAAAGCTCTGACACGTAGAGCTCTTTTGTAAGATTTATTATT CACTCAAGAGTTCGGAAACCACAGTTTTGTCTCTCATCCATACACTGGGGTTTATTTTGCCAAGGTCATCTTTATCAAATTGACTCTTCAAACCCTCGGT TTTTGCCACAGAACAGAGATCTTTCAGGGGAAAGTAGATTTCGAGGTGGAGAGAATTTGCCTTGCTCTTGAGCTGGTCTTTTAACATACTGACGAGCCTT ACTTTTCCTTTGTGGAAATATTAAGTGGCATATTGTGTTCATACCAAAGGTGGAGACAGGATGTGCCAAGTTCATGGTTACTGGACTTCTTATTCCAAGC CATGGCACCAAAGGAGAAGGGGCATTTTGTGGGTGTGCATTAGGTCTGAACTGCTTTATCTTGTTTTAGTTTTCAGTAATTTAACAAAGGGAGCCTGCTG AATAACAAAATTAAAATGATGAAACAAAAGTTTGACAGTGATATTCTGAAGCAAAAACTGTCATCTAAATTTTTCTTGCTGATTTTTTTTAACTTCCCTA TTTTAGAAAACTATTGTTGGGCTGTTGGTAGTGCTTTCCACAGATGCTGGTCCTCAGTGGATTAGGTCAGAAGCTCATGTTCTGATAGTTCTTCATTATT TCACAAAGGTGGACAACCTGAAAGAGAAAAGGCTGCTTGATGTCAGCAGAATCTAAACCCCTACATTAAAGCTTTGCCTCCCATTCTGTGGTTGTGGTGG TGGTAAGAAGGAGATATTGGTACCAAGAAAAATTTCCAAAACTATTGAGAGAGAGAGAGAGAAAGTATTGAAATTTTGTTCTGCCTTGCAGGATCCATTT ATCATTCATTGGTAAAGGATATATTCCTTGTTCTTACCAAGTGTACATTTAACTCTTGCTGACATGTTCAGTGTATTTTATTACTTTTAATGCTGTCTTA AAATGAACATTCTTTAAAGTTGGACAGGAAGGTGGCATTTCTTATTTATTAACATTTTTAACTTTAAACATATTGTGACTCATCTAGACCTTTTAATAAG ACGGTCAACTTCACACTTAGGGAAAAAATTAAAATGTGATGGCCACTTCTAATAATTCAGGTAGTTATAAGGGATCTGGAAGAAATCCAGTCTTTATGAA TATACTATTAGTTGGGCATTAAAAAATCAGTATATATTTTAACTTTTTGTGACATGCTAACACATTTTCAGAATAATTATTGCATAGTAGAATTTATTAC TCCAGAACAGAAAGACCTTACTTCATTTCAAATGAAGTTAATTAATTTACATTTCTGGGTAAAAACTGGTTCTATAAATTAAGTAGAGTAGCTTCTTTAT GATAAAGACAATTTTCTGAAAAGTGAACAATTCTGTTAAAAGAACTTTATTGATGTGTAGATTTCGCACTTTATTTCTGAGACTGCGTTCATGTAGTTGT TCCCCAATGTTTGAGTACTAAGAGAACTTGAGAAAATTACTTCATAAACATATGGAAACTGAAAATGGACTCTCTTTGTGACAAAGATATTCAACAGAAA ATATTGACCCTGCATTGCAAAACACAGGTTCGGGTTCCCTAAGTCCCACAGTGTAATGATTACAAATATCCTAGTGTCCGGTCTAGAAAGACTTTCTAGG AGAAGACTAGTGGAATTTTCTAAAGGTTCAGTTTTAGCTTTTATAACTTAAATTTGGCCCTGTTACGTTCTTTTTAATTTGAACCATAAGGTATCTCCCC TCCCTTCAGGAATAACTTATTGGAAAACTGAAAAGAATCACTGAATGGAATGTTCATTTTATGGCAGTTGTTTTAAGTTTTAAAATACACAGAGGAAAAT ATTGTGGAAGGACCTCTTTGTTGCTTTCCCTTCTAAGTTGTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTTGGTCCTTAAGTGAAATAAAGACTCTAAA ACTAATTTGTATATTATCAGCCAGAGATGCGGATGGCAGTCGAGCCAAATCGCATGGCTTTCAGATCAGGTATTCTGCACATTCATTCCAAGGTCATAGA TTTTTAAAAGGACCTGGATTTGAAGAGATGGCAAATGATGAGCCATCAGAAAACTTAATTTGGAAAACATGTATGTAGCCAGTGTGGATATTGTGGCCTC TCTCAAGACACATTGACACTGTAGACTTCATTCAGTCCAGTGTGAGTATTTTGGAGTAGGTTGGATGTAGATTTTGTTTTTATCATTGATTTGTACCGAC AGAAATAGACATTTCATCATGTAAAATTCCTGTTATTCTGGAAAAACCTATTGTTTTGATCTTCTTGTTTTCTGACTTGGAAGTATCCTTTCAAAAAAAC TCTTAAGATATCTAGGTCTAAAAAGCACTTCATGAGATGCTAAAGCTGACCCACTGGTTGAAAATGTTGACCCTATCCTGTTATTTAAATGTGAACATTT ATTGTACATTCAGTGAGTTATAGTGTTAATAGTCTTGTGCTATGCAGCAGGTGTAAAAATTAATAAATATATTTTTTAATAAACATGTTTGTATGTGTGA AGCTACAAGA

refseq_PRDM10.F1 (forward primer)
refseq_PRDM10.R1 (reverse primer)
Alternative donor

Frame 0

TLRREEPPGGGGGG*FLSPLGREDRGPADLPAP LTQRRACCRQTFPSFMNTRVVDR*LSCTLCCSRC ARRGAVQLGEDGFQR*KLACVADICRA*TECRT GALCSGHRNSGSDCLYR*PGSPPTAGGVHGRWC LLHISGWSRAHAGVHPPGGSCTDSVYRPRPGSLC PTGCYSSAGLIASS*PGAAFHRECRWVRPFGNS ADPSRQTGGQRGRG*G*GRGH*GR*GRRR*GHG SG*LGARPAPALRPTRLVV*GVQ*RACFSVSEAR PLAPDPQPAGAHPGQGEPPPGALHRQVSGRGVL QAAHPQAHPVWPRGGASRQGLGAERLLHSPQGF S**RGQERKGFT*RPMV*VV**DAL*LDDVCTAS PESPGAEPGGLPVWPPCVLYNHKKCGAQAGTEG VVCRILC*VREPENS*HF*GRKESSSRAREELA LL*M*PPIYKLGAVATASQFS**ETRCV*QNKRQ RKGTRQEAIRSRSTAGASSKIYPPGNHQRKWGK E*RWDTGLATFSHKGAI**G*TSHSEWAGSTRT DHYPNPSAATGNPVFPGT*TRNSHPAPAAAA*RE RGAHPEHADSRRHAQSQAHPKCSSSASVYSEVL PAF*MLAVWEGLPGKGQTGPALTLPWAGGELPT DL*SL*QGLHQQHILGEPHEAPLRPEDLLLHFLP RIL*PP*FVERSCGHSYQ*WLLHLPNL*ETVPR FYPGEKTRAQLPLRKDLPVHRV*QGLLSPR*TA TPHAPAFGPQRLPVFHLWEAI*AKRQTTGTHAED A*S*EGGQESRPHQPLQDVQAPHHVHRLRQLHV QVPPVHDGLPAARHAGKSLIEETPRHEDRRGAR VNSTHHKTQS*LLLSVLR*GL*KCQQAQSPHSEE PPRSRAPTEHSEAPTRWSWRARPHAEHTHPADG HHRHPSRLLSPLLQAVQQQDQDGPAHSKEASRV RPALQHHTHTTDDSCDQCHPSGFDYRQRHWRDCG DDGPAHPSNDRTVPDLNDRLPNATRGLPENSVH PCVAVGVWPPAASAHTAASGSSGLGHFPSPVTA VHCGCWPAP*SSALPPARHPGAAHPGQRAYRLGP VLRPGIWAAVESLSPAGSAGAQPLPHPGQFFHT GAGSAAAAAAAAEFLCAAHVPAQCLEFLPWLFI *DSNDDASSGSVCDYRQWCGNSSYYWPGEGGYFG SLCVIRKSIRIGRKANFCPLWWSPGRATCTQ*L PGPPDQQPTADHTVHHHHHHQRERKQRSAYHQT MTSTLELESSTHLMSVLISLKALTRRALL*DLLF TQEFGNHSFVSHPYTGVYFAKVIFIKLTLQTLG FCHRTEIFQGKVDFEVERICLALELVF*HTDEP YFSFVEILSGILCSYQRWRQDVPSSWLLDFLFQA MAPKEKGHFVGVH*V*TALSCFSFQ*FNKGSLL NNKIKMMKQKFDSDILKQKLSSKFFLLIFFNFP ILENYCWAVGSAFHRCWSSVD*VRSSCSDSSSLF HKGGQPEREKAA*CQQNLNPYIKALPPILWLWW W*EGDIGTKKNFQNY*ERERESIEILFCLAGSI YHSLVKDIFLVLTKCTFNSC*HVQCILLLLMLS* NEHSLKLDRKVAFLIY*HF*L*TYCDSSRPFNK TVNFTLREKIKM*WPLLIIQVVIRDLEEIQSL* IYY*LGIKKSVYILTFCDMLTHFQNNYCIVEFIT PEQKDLTSFQMKLINLHFWVKTGSIN*VE*LLY DKDNFLKSEQFC*KNFIDV*ISHFISETAFM*L FPNV*VLRELEKITS*TYGN*KWTLFVTKIFNRK Y*PCIAKHRFGFPKSHSVMITNILVSGLERLSR RRLVEFSKGSVLAFIT*IWPCYVLFNLNHKVSP LPSGITYWKTEKNH*MECSFYGSCFKF*NTQRKI LWKDLFVAFPSKLSSSSSSSSSSLVLK*NKDSK TNLYIISQRCGWQSSQIAWLSDQVFCTFIPRS* IFKRTWI*RDGK**AIRKLNLENMYVASVDIVAS LKTH*HCRLHSVQCEYFGVGWM*ILFLSLICTD RNRHFIM*NSCYSGKTYCFDLLVF*LGSILSKK LLRYLGLKSTS*DAKADPLVENVDPILLFKCEHL LYIQ*VIVLIVLCYAAGVKINKYIF**TCLYV* SYK

Frame 1

LCGGKNHLEVAGGVDFYHP*GERIGDPLIFQLP SPNVVHAADRPFRPS*THVW*TDDCPVPCAALG VPDVELSSWEKMDSKDESSHVWPTSAEHEQNAAQ VHFVPDTGTVAQIVYTDDQVRPPQQVVYTADGA SYTSVDGPEHTLVYIHPVEAAQTLFTDPGQVAY VQQDATAQQASLPVHNQVLPSIESVDGSDPLATL QTPLGRLEAKEEEDEDEDEDTEEDEEEDGEDTD LDDWEPDPPRPFDPHDLWCEECNNAHASVCPKH GPLHPIPNRPVLTRARASLPLVLYIDRFLGGVFS KRRIPKRTQFGPVEGPLVRGSELKDCYIHLKVS LDKGDRKERDLHEDLWFELSDETLCNWMMFVRP AQNHLEQNLVAYQYGHHVYYTTIKNVEPKQELKV WYAASYAEFVNQKIHDISEEERKVLREQEKNWP CYECNRRFISSEQLQQHLNSHDEKLDVFSRTRG RGRGRGKRRFGPGRRPGRPPKFIRLEITSENGEK SDDGTQDLLHFPTKEQFDEAEPATLNGLDQPEQ TTIPIPQLPQETQSSLEHEPETHTLHLQPQHEE SVVPTQSTLTADDMRRAKRIRNAALQHLFIRKSF RPFKCLQCGKAFREKDKLDQHLRFHGREGNCPL TCDLCNKGFISSTSLESHMKLHSDQKTYSCIFC PESFDRLDLLKDHVAIHINDGYFTCPTCKKRFPD FIQVKKHVRSFHSEKIYQCTECDKAFCRPDKLR LHMLRHSDRKDFLCSTCGKQFKRKDKLREHMQR MHNPEREAKKADRISRSKTFKPRITSTDYDSFTF KCRLCMMGFRRRGMLVNHLSKRHPDMKIEEVPE LTLPIIKPNRDYFCQYCDKVYKSASKRKAHILK NHPGAELPPSIRKLRPAGPGEPDPMLSTHTQLTG TIATPPVCCPHCSKQYSSKTKMVQHIRKKHPEF AQLSNTIHTPLTTAVISATPAVLTTDSATGETV VTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYI PVSQSASGLQQPQHIQLQVVQVASATSPHQSQQ STVDVGQLHDPQPYPQHAIQVQHIQVSEPTASA PSSAQVSGQPLSPSAQQAQQGLSPSHIQGSSSTQ GQALQQQQQQQQNSSVQHTYLPSAWNSFRGYSS EIQMMTLPPGQFVITDSGVATPVTTGQVKAVTS GHYVLSESQSELEEKQTSALSGGVQVEPPAHSDS LDPQTNSQQQTTQYIITTTTNGNGSSEVHITKP *LPPWSLNPAPTSCLFS*V*KL*HVELFCKIYY SLKSSETTVLSLIHTLGFILPRSSLSN*LFKPSV FATEQRSFRGK*ISRWREFALLLSWSFNILTSL TFPLWKY*VAYCVHTKGGDRMCQVHGYWTSYSK PWHQRRRGILWVCIRSELLYLVLVFSNLTKGAC* ITKLK**NKSLTVIF*SKNCHLNFSC*FFLTSL F*KTIVGLLVVLSTDAGPQWIRSEAHVLIVLHY FTKVDNLKEKRLLDVSRI*TPTLKLCLPFCGCGG GKKEILVPRKISKTIEREREKVLKFCSALQDPF IIHW*RIYSLFLPSVHLTLADMFSVFYYF*CCL KMNIL*SWTGRWHFLFINIFNFKHIVTHLDLLIR RSTSHLGKKLKCDGHF**FR*L*GIWKKSSLYE YTISWALKNQYIF*LFVTC*HIFRIIIA**NLL LQNRKTLLHFK*S*LIYISG*KLVL*IK*SSFFM IKTIF*KVNNSVKRTLLMCRFRTLFLRLRSCSC SPMFEY*ENLRKLLHKHMETENGLSL*QRYSTE NIDPALQNTGSGSLSPTV**LQIS*CPV*KDFLG ED*WNFLKVQF*LL*LKFGPVTFFLI*TIRYLP SLQE*LIGKLKRITEWNVHFMAVVLSFKIHRGK YCGRTSLLLSLLSCLLLLLLLLLLWSLSEIKTLK LICILSARDADGSRAKSHGFQIRYSAHSFQGHR FLKGPGFEEMANDEPSENLIWKTCM*PVWILWP LSRHIDTVDFIQSSVSILE*VGCRFCFYH*FVPT EIDISSCKIPVILEKPIVLIFLFSDLEVSFQKN S*DI*V*KALHEMLKLTHWLKMLTLSCYLNVNI YCTFSEL*C**SCAMQQV*KLINIFFNKHVCMCE ATR

Frame 2

SAAGRTTWRWRGGLISITPRERGSGTR*SSSSP HPTSCMLQTDLSVLHEHTCGRQMTVLYPVLL*V CQTWSCPVGRRWIPKMKARMCGRHLQSMNRMPH RCTLFRTQEQWLRLSIPMTRFAPHSRWCTRQMVP PTHQWMVQSTRWCTSTRWKLHRLCLQTPAR*LM SNRMLQLSRPHCQFITRCCLPSRV*MGPTLWQL CRPL*ADWRPKRKRMRMRTRTLRKMRKKTVRTRI WMTGSQTRPGPSTHTTCGVRSAITRMLQCVRST APCTRSPTGRCSPGPGRASPWCST*TGFWAGCS PSGASPSAPSLAPWRGLSSGARS*KTVTFTSRFL LIKGTGKKGIYMKTYGLSCLMRRFVTG*CLYGQ PRITWSRTWWLTSMATMCIIQP*KMWSPSRN*R CGMPHPMLSS*TRKFMTFLRKKGKFFESKRRIGP AMNVTADL*ARSSCNSISILMMRN*MCLAEQEA EEGDEARGDSVQVDGRGVLQNLSAWKSPAKMGK RVTMGHRTCYIFPQRSNLMRLNQPL*MGWINQNR PLSQSLSCHRKPSLPWNMNQKLTPCTCSRSMKR AWCPPRAR*QPTTCAEPSASEMQLFSICLFGSP SGLLNACSVGRPSGKRTNWTSTYASMGGRGTAH* PVISVTRASSAAHPWRAT*SSTQTRRLTLAFFA QNPLTALIC*KIMWPFISMMATSPAQLVRNGSQ ILSR*KNTCAASTQKRSTSAQSVTRPSVAPINCD STCSGIRTAKTSCVPPVGSNLSEKTNYGNTCRG CIILRGRPRKPTASAAPRRSSPASRPQTTTASR SSAACA*WASGGAACW*ITYRRDTQT*R*KRCQS *LYPS*NPIVITFVSIAIRFIKVPASAKPTF*R TTQEQSSHRAFGSSDPLVLESQTPC*AHTPS*R APSPPLPSAVPTAPSSTAARPRWSSTFERSIQSS PSSPTPYTHH*RQL*SVPPQRF*LQTAPLERLW *RRTCSPKQ*QNCPRP*RQTTERHKGITREFST SLCRSRRLASSSLSTYSCKWFKWPRPLPLTSHSS PLWMLASSMILSPTPSTPSRCSTSRSASLPPRP RPPPRYLGSR*VPQPSRLSRGSAPPTSRAVLPH RGRLCSSSSSSSRIPLCSTRTCPVLGIPSVAIHL RFK**RFLRVSL*LQTVVWQLQLLLAR*RRLLR VIMCYQKVNQNWKKSKLLPSLVESRSSHLHTVT PWTPRPTANSRPHSTSSPPPPTGTEAAKCISPNH DFHPGA*IQHPPHVCSHKSESSDT*SSFVRFII HSRVRKPQFCLSSIHWGLFCQGHLYQIDSSNPR FLPQNRDLSGESRFRGGENLPCS*AGLLTY*RAL LFLCGNIKWHIVFIPKVETGCAKFMVTGLLIPS HGTKGEGAFCGCALGLNCFILF*FSVI*QREPA E*QN*NDETKV*Q*YSEAKTVI*IFLADFF*LPY FRKLLLGCW*CFPQMLVLSGLGQKLMF**FFII SQRWTT*KRKGCLMSAESKPLH*SFASHSVVVV VVRRRYWYQEKFPKLLRERERKY*NFVLPCRIHL SFIGKGYIPCSYQVYI*LLLTCSVYFITFNAVL K*TFFKVGQEGGISYLLTFLTLNIL*LI*TF** DGQLHT*GKN*NVMATSNNSGSYKGSGRNPVFMN ILLVGH*KISIYFNFL*HANTFSE*LLHSRIYY SRTERPYFISNEVN*FTFLGKNWFYKLSRVASL **RQFSEK*TILLKELY*CVDFALYF*DCVHVVV PQCLSTKRT*ENYFINIWKLKMDSLCDKDIQQK ILTLHCKTQVRVP*VPQCNDYKYPSVRSRKTF* EKTSGIF*RFSFSFYNLNLALLRSF*FEP*GISP PFRNNLLEN*KESLNGMFILWQLF*VLKYTEEN IVEGPLCCFPF*VVFFFFFFFFFFGP*VK*RL* N*FVYYQPEMRMAVEPNRMAFRSGILHIHSKVID F*KDLDLKRWQMMSHQKT*FGKHVCSQCGYCGL SQDTLTL*TSFSPV*VFWSRLDVDFVFIIDLYR QK*TFHHVKFLLFWKNLLF*SSCFLTWKYPFKKT LKISRSKKHFMRC*S*PTG*KC*PYPVI*M*TF IVHSVSYSVNSLVLCSRCKN**IYFLINMFVCV KLQ

Sequence NM_020228

ACTCTGCGGCGGGAAGAACCACCTGGAGGTGGCGGGGGGGGTTGATTTCTATCACCCCTAGGGAGAGAGGATCGGGGACCCGCTGATCTTCCAGCTCCCC TCACCCAACGTCGTGCATGCTGCAGACAGACCTTTCCGTCCTTCATGAACACACGTGTGGTAGACAGATGACTGTCCTGTACCCTGTGCTGCTCTAGGTG TGCCAGACGTGGAGCTGTCCAGTTGGGAGAAGATGGATTCCAAAGATGAAAGCTCGCATGTGTGGCCGACATCTGCAGAGCATGAACAGAATGCCGCACA GGTGCACTTTGTTCCGGACACAGGAACAGTGGCTCAGATTGTCTATACCGATGACCAGGTTCGCCCCCCACAGCAGGTGGTGTACACGGCAGATGGTGCC TCCTACACATCAGTGGATGGTCCAGAGCACACGCTGGTGTACATCCACCCGGTGGAAGCTGCACAGACTCTGTTTACAGACCCCGGCCAGGTAGCTTATG TCCAACAGGATGCTACAGCTCAGCAGGCCTCATTGCCAGTTCATAACCAGGTGCTGCCTTCCATCGAGAGTGTAGATGGGTCCGACCCTTTGGCAACTCT GCAGACCCCTCTAGGCAGACTGGAGGCCAAAGAGGAAGAGGATGAGGATGAGGACGAGGACACTGAGGAAGATGAGGAAGAAGACGGTGAGGACACGGAT CTGGATGACTGGGAGCCAGACCCGCCCCGGCCCTTCGACCCACACGACTTGTGGTGTGAGGAGTGCAATAACGCGCATGCTTCAGTGTGTCCGAAGCACG GCCCCTTGCACCCGATCCCCAACCGGCCGGTGCTCACCCGGGCCAGGGCGAGCCTCCCCCTGGTGCTCTACATAGACAGGTTTCTGGGCGGGGTGTTCTC CAAGCGGCGCATCCCCAAGCGCACCCAGTTTGGCCCCGTGGAGGGGCCTCTCGTCAGGGGCTCGGAGCTGAAAGACTGTTACATTCACCTCAAGGTTTCT CTTGATAAAGGGGACAGGAAAGAAAGGGATTTACATGAAGACCTATGGTTTGAGTTGTCTGATGAGACGCTTTGTAACTGGATGATGTTTGTACGGCCAG CCCAGAATCACCTGGAGCAGAACCTGGTGGCTTACCAGTATGGCCACCATGTGTATTATACAACCATAAAAAATGTGGAGCCCAAGCAGGAACTGAAGGT GTGGTATGCCGCATCCTATGCTGAGTTCGTGAACCAGAAAATTCATGACATTTCTGAGGAAGAAAGGAAAGTTCTTCGAGAGCAAGAGAAGAATTGGCCC TGCTATGAATGTAACCGCCGATTTATAAGCTCGGAGCAGTTGCAACAGCATCTCAATTCTCATGATGAGAAACTAGATGTGTTTAGCAGAACAAGAGGCA GAGGAAGGGGACGAGGCAAGAGGCGATTCGGTCCAGGTCGACGGCCGGGGCGTCCTCCAAAATTTATCCGCCTGGAAATCACCAGCGAAAATGGGGAAAA GAGTGACGATGGGACACAGGACTTGCTACATTTTCCCACAAAGGAGCAATTTGATGAGGCTGAACCAGCCACTCTGAATGGGCTGGATCAACCAGAACAG ACCACTATCCCAATCCCTCAGCTGCCACAGGAAACCCAGTCTTCCCTGGAACATGAACCAGAAACTCACACCCTGCACCTGCAGCCGCAGCATGAAGAGA GCGTGGTGCCCACCCAGAGCACGCTGACAGCCGACGACATGCGCAGAGCCAAGCGCATCCGATTGGAGCTGCAGAATGCAGCTCTTCAGCATCTGTTTAT TCGGAAGTCCTTCCGGCCTTTTAAATGCTTGCAGTGTGGGAAGGCCTTCCGGGAAAAGGACAAACTGGACCAGCACTTACGCTTCCATGGGCGGGAGGGG AACTGCCCACTGACCTGTGATCTCTGTAACAAGGGCTTCATCAGCAGCACATCCTTGGAGAGCCACATGAAGCTCCACTCAGACCAGAAGACTTACTCTT GCATTTTTTGCCCAGAATCCTTTGACCGCCTTGATTTGTTGAAAGATCATGTGGCCATTCATATCAATGATGGCTACTTCACCTGCCCAACTTGTAAGAA ACGGTTCCCAGATTTTATCCAGGTGAAAAAACACGTGCGCAGCTTCCACTCAGAAAAGATCTACCAGTGCACAGAGTGTGACAAGGCCTTCTGTCGCCCC GATAAACTGCGACTCCACATGCTCCGGCATTCGGACCGCAAAGACTTCCTGTGTTCCACCTGTGGGAAGCAATTTAAGCGAAAAGACAAACTACGGGAAC ACATGCAGAGGATGCATAATCCTGAGAGGGAGGCCAAGAAAGCCGACCGCATCAGCCGCTCCAAGACGTTCAAGCCCCGCATCACGTCCACAGACTACGA CAGCTTCACGTTCAAGTGCCGCCTGTGCATGATGGGCTTCCGGCGGCGCGGCATGCTGGTAAATCACTTATCGAAGAGACACCCAGACATGAAGATAGAA GAGGTGCCAGAGTTAACTCTACCCATCATAAAACCCAATCGTGATTACTTTTGTCAGTATTGCGATAAGGTTTATAAAAGTGCCAGCAAGCGCAAAGCCC ACATTCTGAAGAACCACCCAGGAGCAGAGCTCCCACCGAGCATTCGGAAGCTCCGACCCGCTGGTCCTGGAGAGCCAGACCCCATGCTGAGCACACACAC CCAGCTGACGGGCACCATCGCCACCCCTCCCGTCTGCTGTCCCCACTGCTCCAAGCAGTACAGCAGCAAGACCAAGATGGTCCAGCACATTCGAAAGAAG CATCCAGAGTTCGCCCAGCTCTCCAACACCATACACACACCACTGACGACAGCTGTGATCAGTGCCACCCCAGCGGTTTTGACTACAGACAGCGCCACTG GAGAGACTGTGGTGACGACGGACCTGCTCACCCAAGCAATGACAGAACTGTCCCAGACCTTAACGACAGACTACCGAACGCCACAAGGGGATTACCAGAG AATTCAGTACATCCCTGTGTCGCAGTCGGCGTCTGGCCTCCAGCAGCCTCAGCACATACAGCTGCAAGTGGTTCAAGTGGCCTCGGCCACTTCCCCTCAC CAGTCACAGCAGTCCACTGTGGATGTTGGCCAGCTCCATGATCCTCAGCCCTACCCCCAGCACGCCATCCAGGTGCAGCACATCCAGGTCAGCGAGCCTA CCGCCTCGGCCCCGTCCTCCGCCCAGGTATCTGGGCAGCCGTTGAGTCCCTCAGCCCAGCAGGCTCAGCAGGGGCTCAGCCCCTCCCACATCCAGGGCAG TTCTTCCACACAGGGGCAGGCTCTGCAGCAGCAGCAGCAGCAGCAGCAGAATTCCTCTGTGCAGCACACGTACCTGCCCAGTGCTTGGAATTCCTTCCGT GGCTATTCATCTGAGATTCAAATGATGACGCTTCCTCCGGGTCAGTTTGTGATTACAGACAGTGGTGTGGCAACTCCAGTTACTACTGGCCAGGTGAAGG CGGTTACTTCGGGTCATTATGTGTTATCAGAAAGTCAATCAGAATTGGAAGAAAAGCAAACTTCTGCCCTCTCTGGTGGAGTCCAGGTCGAGCCACCTGC ACACAGTGACTCCCTGGACCCCCAGACCAACAGCCAACAGCAGACCACACAGTACATCATCACCACCACCACCAACGGGAACGGAAGCAGCGAAGTGCAT ATCACCAAACCATGACTTCCACCCTGGAGCTTGAATCCAGCACCCACCTCATGTCTGTTCTCATAAGTCTGAAAGCTCTGACACGTAGAGCTCTTTTGTA AGATTTATTATTCACTCAAGAGTTCGGAAACCACAGTTTTGTCTCTCATCCATACACTGGGGTTTATTTTGCCAAGGTCATCTTTATCAAATTGACTCTT CAAACCCTCGGTTTTTGCCACAGAACAGAGATCTTTCAGGGGAAAGTAGATTTCGAGGTGGAGAGAATTTGCCTTGCTCTTGAGCTGGTCTTTTAACATA CTGACGAGCCTTACTTTTCCTTTGTGGAAATATTAAGTGGCATATTGTGTTCATACCAAAGGTGGAGACAGGATGTGCCAAGTTCATGGTTACTGGACTT CTTATTCCAAGCCATGGCACCAAAGGAGAAGGGGCATTTTGTGGGTGTGCATTAGGTCTGAACTGCTTTATCTTGTTTTAGTTTTCAGTAATTTAACAAA GGGAGCCTGCTGAATAACAAAATTAAAATGATGAAACAAAAGTTTGACAGTGATATTCTGAAGCAAAAACTGTCATCTAAATTTTTCTTGCTGATTTTTT TTAACTTCCCTATTTTAGAAAACTATTGTTGGGCTGTTGGTAGTGCTTTCCACAGATGCTGGTCCTCAGTGGATTAGGTCAGAAGCTCATGTTCTGATAG TTCTTCATTATTTCACAAAGGTGGACAACCTGAAAGAGAAAAGGCTGCTTGATGTCAGCAGAATCTAAACCCCTACATTAAAGCTTTGCCTCCCATTCTG TGGTTGTGGTGGTGGTAAGAAGGAGATATTGGTACCAAGAAAAATTTCCAAAACTATTGAGAGAGAGAGAGAGAAAGTATTGAAATTTTGTTCTGCCTTG CAGGATCCATTTATCATTCATTGGTAAAGGATATATTCCTTGTTCTTACCAAGTGTACATTTAACTCTTGCTGACATGTTCAGTGTATTTTATTACTTTT AATGCTGTCTTAAAATGAACATTCTTTAAAGTTGGACAGGAAGGTGGCATTTCTTATTTATTAACATTTTTAACTTTAAACATATTGTGACTCATCTAGA CCTTTTAATAAGACGGTCAACTTCACACTTAGGGAAAAAATTAAAATGTGATGGCCACTTCTAATAATTCAGGTAGTTATAAGGGATCTGGAAGAAATCC AGTCTTTATGAATATACTATTAGTTGGGCATTAAAAAATCAGTATATATTTTAACTTTTTGTGACATGCTAACACATTTTCAGAATAATTATTGCATAGT AGAATTTATTACTCCAGAACAGAAAGACCTTACTTCATTTCAAATGAAGTTAATTAATTTACATTTCTGGGTAAAAACTGGTTCTATAAATTAAGTAGAG TAGCTTCTTTATGATAAAGACAATTTTCTGAAAAGTGAACAATTCTGTTAAAAGAACTTTATTGATGTGTAGATTTCGCACTTTATTTCTGAGACTGCGT TCATGTAGTTGTTCCCCAATGTTTGAGTACTAAGAGAACTTGAGAAAATTACTTCATAAACATATGGAAACTGAAAATGGACTCTCTTTGTGACAAAGAT ATTCAACAGAAAATATTGACCCTGCATTGCAAAACACAGGTTCGGGTTCCCTAAGTCCCACAGTGTAATGATTACAAATATCCTAGTGTCCGGTCTAGAA AGACTTTCTAGGAGAAGACTAGTGGAATTTTCTAAAGGTTCAGTTTTAGCTTTTATAACTTAAATTTGGCCCTGTTACGTTCTTTTTAATTTGAACCATA AGGTATCTCCCCTCCCTTCAGGAATAACTTATTGGAAAACTGAAAAGAATCACTGAATGGAATGTTCATTTTATGGCAGTTGTTTTAAGTTTTAAAATAC ACAGAGGAAAATATTGTGGAAGGACCTCTTTGTTGCTTTCCCTTCTAAGTTGTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTTGGTCCTTAAGTGAAAT AAAGACTCTAAAACTAATTTGTATATTATCAGCCAGAGATGCGGATGGCAGTCGAGCCAAATCGCATGGCTTTCAGATCAGGTATTCTGCACATTCATTC CAAGGTCATAGATTTTTAAAAGGACCTGGATTTGAAGAGATGGCAAATGATGAGCCATCAGAAAACTTAATTTGGAAAACATGTATGTAGCCAGTGTGGA TATTGTGGCCTCTCTCAAGACACATTGACACTGTAGACTTCATTCAGTCCAGTGTGAGTATTTTGGAGTAGGTTGGATGTAGATTTTGTTTTTATCATTG ATTTGTACCGACAGAAATAGACATTTCATCATGTAAAATTCCTGTTATTCTGGAAAAACCTATTGTTTTGATCTTCTTGTTTTCTGACTTGGAAGTATCC TTTCAAAAAAACTCTTAAGATATCTAGGTCTAAAAAGCACTTCATGAGATGCTAAAGCTGACCCACTGGTTGAAAATGTTGACCCTATCCTGTTATTTAA ATGTGAACATTTATTGTACATTCAGTGAGTTATAGTGTTAATAGTCTTGTGCTATGCAGCAGGTGTAAAAATTAATAAATATATTTTTTAATAAACATGT TTGTATGTGTGAAGCTACAAGA

refseq_PRDM10.F1 (forward primer)
refseq_PRDM10.R1 (reverse primer)
Alternative donor

Frame 0

TLRREEPPGGGGGG*FLSPLGREDRGPADLPAP LTQRRACCRQTFPSFMNTRVVDR*LSCTLCCSRC ARRGAVQLGEDGFQR*KLACVADICRA*TECRT GALCSGHRNSGSDCLYR*PGSPPTAGGVHGRWC LLHISGWSRAHAGVHPPGGSCTDSVYRPRPGSLC PTGCYSSAGLIASS*PGAAFHRECRWVRPFGNS ADPSRQTGGQRGRG*G*GRGH*GR*GRRR*GHG SG*LGARPAPALRPTRLVV*GVQ*RACFSVSEAR PLAPDPQPAGAHPGQGEPPPGALHRQVSGRGVL QAAHPQAHPVWPRGGASRQGLGAERLLHSPQGF S**RGQERKGFT*RPMV*VV**DAL*LDDVCTAS PESPGAEPGGLPVWPPCVLYNHKKCGAQAGTEG VVCRILC*VREPENS*HF*GRKESSSRAREELA LL*M*PPIYKLGAVATASQFS**ETRCV*QNKRQ RKGTRQEAIRSRSTAGASSKIYPPGNHQRKWGK E*RWDTGLATFSHKGAI**G*TSHSEWAGSTRT DHYPNPSAATGNPVFPGT*TRNSHPAPAAAA*RE RGAHPEHADSRRHAQSQAHPIGAAECSSSASVY SEVLPAF*MLAVWEGLPGKGQTGPALTLPWAGG ELPTDL*SL*QGLHQQHILGEPHEAPLRPEDLLL HFLPRIL*PP*FVERSCGHSYQ*WLLHLPNL*E TVPRFYPGEKTRAQLPLRKDLPVHRV*QGLLSP R*TATPHAPAFGPQRLPVFHLWEAI*AKRQTTGT HAEDA*S*EGGQESRPHQPLQDVQAPHHVHRLR QLHVQVPPVHDGLPAARHAGKSLIEETPRHEDR RGARVNSTHHKTQS*LLLSVLR*GL*KCQQAQSP HSEEPPRSRAPTEHSEAPTRWSWRARPHAEHTH PADGHHRHPSRLLSPLLQAVQQQDQDGPAHSKE ASRVRPALQHHTHTTDDSCDQCHPSGFDYRQRHW RDCGDDGPAHPSNDRTVPDLNDRLPNATRGLPE NSVHPCVAVGVWPPAASAHTAASGSSGLGHFPS PVTAVHCGCWPAP*SSALPPARHPGAAHPGQRAY RLGPVLRPGIWAAVESLSPAGSAGAQPLPHPGQ FFHTGAGSAAAAAAAAEFLCAAHVPAQCLEFLP WLFI*DSNDDASSGSVCDYRQWCGNSSYYWPGEG GYFGSLCVIRKSIRIGRKANFCPLWWSPGRATC TQ*LPGPPDQQPTADHTVHHHHHHQRERKQRSA YHQTMTSTLELESSTHLMSVLISLKALTRRALL* DLLFTQEFGNHSFVSHPYTGVYFAKVIFIKLTL QTLGFCHRTEIFQGKVDFEVERICLALELVF*H TDEPYFSFVEILSGILCSYQRWRQDVPSSWLLDF LFQAMAPKEKGHFVGVH*V*TALSCFSFQ*FNK GSLLNNKIKMMKQKFDSDILKQKLSSKFFLLIF FNFPILENYCWAVGSAFHRCWSSVD*VRSSCSDS SSLFHKGGQPEREKAA*CQQNLNPYIKALPPIL WLWWW*EGDIGTKKNFQNY*ERERESIEILFCL AGSIYHSLVKDIFLVLTKCTFNSC*HVQCILLLL MLS*NEHSLKLDRKVAFLIY*HF*L*TYCDSSR PFNKTVNFTLREKIKM*WPLLIIQVVIRDLEEI QSL*IYY*LGIKKSVYILTFCDMLTHFQNNYCIV EFITPEQKDLTSFQMKLINLHFWVKTGSIN*VE *LLYDKDNFLKSEQFC*KNFIDV*ISHFISETA FM*LFPNV*VLRELEKITS*TYGN*KWTLFVTKI FNRKY*PCIAKHRFGFPKSHSVMITNILVSGLE RLSRRRLVEFSKGSVLAFIT*IWPCYVLFNLNH KVSPLPSGITYWKTEKNH*MECSFYGSCFKF*NT QRKILWKDLFVAFPSKLSSSSSSSSSSLVLK*N KDSKTNLYIISQRCGWQSSQIAWLSDQVFCTFI PRS*IFKRTWI*RDGK**AIRKLNLENMYVASVD IVASLKTH*HCRLHSVQCEYFGVGWM*ILFLSL ICTDRNRHFIM*NSCYSGKTYCFDLLVF*LGSI LSKKLLRYLGLKSTS*DAKADPLVENVDPILLFK CEHLLYIQ*VIVLIVLCYAAGVKINKYIF**TC LYV*SYK

Frame 1

LCGGKNHLEVAGGVDFYHP*GERIGDPLIFQLP SPNVVHAADRPFRPS*THVW*TDDCPVPCAALG VPDVELSSWEKMDSKDESSHVWPTSAEHEQNAAQ VHFVPDTGTVAQIVYTDDQVRPPQQVVYTADGA SYTSVDGPEHTLVYIHPVEAAQTLFTDPGQVAY VQQDATAQQASLPVHNQVLPSIESVDGSDPLATL QTPLGRLEAKEEEDEDEDEDTEEDEEEDGEDTD LDDWEPDPPRPFDPHDLWCEECNNAHASVCPKH GPLHPIPNRPVLTRARASLPLVLYIDRFLGGVFS KRRIPKRTQFGPVEGPLVRGSELKDCYIHLKVS LDKGDRKERDLHEDLWFELSDETLCNWMMFVRP AQNHLEQNLVAYQYGHHVYYTTIKNVEPKQELKV WYAASYAEFVNQKIHDISEEERKVLREQEKNWP CYECNRRFISSEQLQQHLNSHDEKLDVFSRTRG RGRGRGKRRFGPGRRPGRPPKFIRLEITSENGEK SDDGTQDLLHFPTKEQFDEAEPATLNGLDQPEQ TTIPIPQLPQETQSSLEHEPETHTLHLQPQHEE SVVPTQSTLTADDMRRAKRIRLELQNAALQHLFI RKSFRPFKCLQCGKAFREKDKLDQHLRFHGREG NCPLTCDLCNKGFISSTSLESHMKLHSDQKTYS CIFCPESFDRLDLLKDHVAIHINDGYFTCPTCKK RFPDFIQVKKHVRSFHSEKIYQCTECDKAFCRP DKLRLHMLRHSDRKDFLCSTCGKQFKRKDKLRE HMQRMHNPEREAKKADRISRSKTFKPRITSTDYD SFTFKCRLCMMGFRRRGMLVNHLSKRHPDMKIE EVPELTLPIIKPNRDYFCQYCDKVYKSASKRKA HILKNHPGAELPPSIRKLRPAGPGEPDPMLSTHT QLTGTIATPPVCCPHCSKQYSSKTKMVQHIRKK HPEFAQLSNTIHTPLTTAVISATPAVLTTDSAT GETVVTTDLLTQAMTELSQTLTTDYRTPQGDYQR IQYIPVSQSASGLQQPQHIQLQVVQVASATSPH QSQQSTVDVGQLHDPQPYPQHAIQVQHIQVSEP TASAPSSAQVSGQPLSPSAQQAQQGLSPSHIQGS SSTQGQALQQQQQQQQNSSVQHTYLPSAWNSFR GYSSEIQMMTLPPGQFVITDSGVATPVTTGQVK AVTSGHYVLSESQSELEEKQTSALSGGVQVEPPA HSDSLDPQTNSQQQTTQYIITTTTNGNGSSEVH ITKP*LPPWSLNPAPTSCLFS*V*KL*HVELFC KIYYSLKSSETTVLSLIHTLGFILPRSSLSN*LF KPSVFATEQRSFRGK*ISRWREFALLLSWSFNI LTSLTFPLWKY*VAYCVHTKGGDRMCQVHGYWT SYSKPWHQRRRGILWVCIRSELLYLVLVFSNLTK GAC*ITKLK**NKSLTVIF*SKNCHLNFSC*FF LTSLF*KTIVGLLVVLSTDAGPQWIRSEAHVLI VLHYFTKVDNLKEKRLLDVSRI*TPTLKLCLPFC GCGGGKKEILVPRKISKTIEREREKVLKFCSAL QDPFIIHW*RIYSLFLPSVHLTLADMFSVFYYF *CCLKMNIL*SWTGRWHFLFINIFNFKHIVTHLD LLIRRSTSHLGKKLKCDGHF**FR*L*GIWKKS SLYEYTISWALKNQYIF*LFVTC*HIFRIIIA* *NLLLQNRKTLLHFK*S*LIYISG*KLVL*IK*S SFFMIKTIF*KVNNSVKRTLLMCRFRTLFLRLR SCSCSPMFEY*ENLRKLLHKHMETENGLSL*QR YSTENIDPALQNTGSGSLSPTV**LQIS*CPV*K DFLGED*WNFLKVQF*LL*LKFGPVTFFLI*TI RYLPSLQE*LIGKLKRITEWNVHFMAVVLSFKI HRGKYCGRTSLLLSLLSCLLLLLLLLLLWSLSEI KTLKLICILSARDADGSRAKSHGFQIRYSAHSF QGHRFLKGPGFEEMANDEPSENLIWKTCM*PVW ILWPLSRHIDTVDFIQSSVSILE*VGCRFCFYH* FVPTEIDISSCKIPVILEKPIVLIFLFSDLEVS FQKNS*DI*V*KALHEMLKLTHWLKMLTLSCYL NVNIYCTFSEL*C**SCAMQQV*KLINIFFNKHV CMCEATR

Frame 2

SAAGRTTWRWRGGLISITPRERGSGTR*SSSSP HPTSCMLQTDLSVLHEHTCGRQMTVLYPVLL*V CQTWSCPVGRRWIPKMKARMCGRHLQSMNRMPH RCTLFRTQEQWLRLSIPMTRFAPHSRWCTRQMVP PTHQWMVQSTRWCTSTRWKLHRLCLQTPAR*LM SNRMLQLSRPHCQFITRCCLPSRV*MGPTLWQL CRPL*ADWRPKRKRMRMRTRTLRKMRKKTVRTRI WMTGSQTRPGPSTHTTCGVRSAITRMLQCVRST APCTRSPTGRCSPGPGRASPWCST*TGFWAGCS PSGASPSAPSLAPWRGLSSGARS*KTVTFTSRFL LIKGTGKKGIYMKTYGLSCLMRRFVTG*CLYGQ PRITWSRTWWLTSMATMCIIQP*KMWSPSRN*R CGMPHPMLSS*TRKFMTFLRKKGKFFESKRRIGP AMNVTADL*ARSSCNSISILMMRN*MCLAEQEA EEGDEARGDSVQVDGRGVLQNLSAWKSPAKMGK RVTMGHRTCYIFPQRSNLMRLNQPL*MGWINQNR PLSQSLSCHRKPSLPWNMNQKLTPCTCSRSMKR AWCPPRAR*QPTTCAEPSASDWSCRMQLFSICL FGSPSGLLNACSVGRPSGKRTNWTSTYASMGGRG TAH*PVISVTRASSAAHPWRAT*SSTQTRRLTL AFFAQNPLTALIC*KIMWPFISMMATSPAQLVR NGSQILSR*KNTCAASTQKRSTSAQSVTRPSVAP INCDSTCSGIRTAKTSCVPPVGSNLSEKTNYGN TCRGCIILRGRPRKPTASAAPRRSSPASRPQTT TASRSSAACA*WASGGAACW*ITYRRDTQT*R*K RCQS*LYPS*NPIVITFVSIAIRFIKVPASAKP TF*RTTQEQSSHRAFGSSDPLVLESQTPC*AHT PS*RAPSPPLPSAVPTAPSSTAARPRWSSTFERS IQSSPSSPTPYTHH*RQL*SVPPQRF*LQTAPL ERLW*RRTCSPKQ*QNCPRP*RQTTERHKGITR EFSTSLCRSRRLASSSLSTYSCKWFKWPRPLPLT SHSSPLWMLASSMILSPTPSTPSRCSTSRSASL PPRPRPPPRYLGSR*VPQPSRLSRGSAPPTSRA VLPHRGRLCSSSSSSSRIPLCSTRTCPVLGIPSV AIHLRFK**RFLRVSL*LQTVVWQLQLLLAR*R RLLRVIMCYQKVNQNWKKSKLLPSLVESRSSHL HTVTPWTPRPTANSRPHSTSSPPPPTGTEAAKCI SPNHDFHPGA*IQHPPHVCSHKSESSDT*SSFV RFIIHSRVRKPQFCLSSIHWGLFCQGHLYQIDS SNPRFLPQNRDLSGESRFRGGENLPCS*AGLLTY *RALLFLCGNIKWHIVFIPKVETGCAKFMVTGL LIPSHGTKGEGAFCGCALGLNCFILF*FSVI*Q REPAE*QN*NDETKV*Q*YSEAKTVI*IFLADFF *LPYFRKLLLGCW*CFPQMLVLSGLGQKLMF** FFIISQRWTT*KRKGCLMSAESKPLH*SFASHS VVVVVVRRRYWYQEKFPKLLRERERKY*NFVLPC RIHLSFIGKGYIPCSYQVYI*LLLTCSVYFITF NAVLK*TFFKVGQEGGISYLLTFLTLNIL*LI* TF**DGQLHT*GKN*NVMATSNNSGSYKGSGRNP VFMNILLVGH*KISIYFNFL*HANTFSE*LLHS RIYYSRTERPYFISNEVN*FTFLGKNWFYKLSR VASL**RQFSEK*TILLKELY*CVDFALYF*DCV HVVVPQCLSTKRT*ENYFINIWKLKMDSLCDKD IQQKILTLHCKTQVRVP*VPQCNDYKYPSVRSR KTF*EKTSGIF*RFSFSFYNLNLALLRSF*FEP* GISPPFRNNLLEN*KESLNGMFILWQLF*VLKY TEENIVEGPLCCFPF*VVFFFFFFFFFFGP*VK *RL*N*FVYYQPEMRMAVEPNRMAFRSGILHIHS KVIDF*KDLDLKRWQMMSHQKT*FGKHVCSQCG YCGLSQDTLTL*TSFSPV*VFWSRLDVDFVFII DLYRQK*TFHHVKFLLFWKNLLF*SSCFLTWKYP FKKTLKISRSKKHFMRC*S*PTG*KC*PYPVI* M*TFIVHSVSYSVNSLVLCSRCKN**IYFLINM FVCVKLQ