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Sequences

Sequence NM_032166

GCGCTGTCGGATACTTGGGGTGAGCGGAAAGCATGGCGGGGACCTCCGCGCCAGGCAGCAAGAGGCGGAGCGAGCCCCCGGCGCCTCGCCCCGGCCCGCC GCCGGGCACCGGGCACCCCCCGAGCAAGCGGGCCCGGGGCTTCTCCGCAGCCGCTGCCCCGGACCCTGACGACCCGTTCGGCGCGCATGGGGACTTCACT GCCGACGACCTGGAGGAGCTTGACACCCTCGCGTCACAGGCCCTGAGCCAATGTCCGGCCGCGGCTCGGGACGTGTCCAGTGATCATAAGGTCCACAGAT TATTAGATGGCATGTCAAAAAATCCTTCAGGGAAAAACAGAGAAACTGTTCCAATTAAAGATAATTTCGAATTAGAGGTACTTCAGGCACAATACAAAGA ACTTAAAGAAAAGATGAAAGTAATGGAAGAAGAAGTTCTCATTAAGAATGGAGAAATTAAAATTTTGCGAGACTCACTACATCAGACGGAATCCGTTCTA GAGGAACAGAGAAGATCACATTTTCTTCTTGAGCAAGAGAAAACCCAAGCACTCAGTGACAAGGAAAAGGAATTCTCCAAAAAGCTCCAATCATTGCAGT CTGAACTCCAGTTTAAAGATGCAGAGATGAATGAATTAAGGACAAAGCTCCAGACCAGTGAACGAGCAAATAAACTGGCTGCTCCCTCTGTTTCCCATGT CAGTCCTAGGAAAAACCCTTCTGTGGTTATAAAGCCAGAAGCATGTTCTCCACAATTTGGAAAAACATCTTTTCCTACAAAGGAGTCTTTTAGTGCTAAC ATGTCCCTTCCCCACCCCTGCCAGACGGAGTCAGGATACAAGCCTCTGGTGGGCAGAGAGGATAGTAAGCCCCACAGTCTGAGAGGTGACTCCATAAAAC AAGAAGAGGCCCAGAAAAGCTTTGTTGACAGCTGGAGACAGAGATCAAACACTCAAGGTTCCATTTTGATAAACCTGCTCCTGAAGCAGCCTTTGATCCC AGGGTCATCCCTAAGCCTTTGCCACCTCCTGAGTAGTAGTTCTGAGTCTCCTGCTGGCACCCCCCTGCAGCCACCAGGGTTTGGCAGTACCTTGGCTGGA ATGTCAGGCCTCAGGACCACAGGTTCTTATGATGGGTCATTTTCCCTCTCAGCCCTGAGAGAAGCACAGAACCTGGCATTCACTGGACTGAATCTGGTTG CCCGGAATGAGTGCTCACGTGATGGAGACCCAGCAGAGGGAGGCAGAAGGGCCTTCCCACTCTGCCAGCTTCCTGGAGCCGTGCATTTCCTCCCCCTTGT ACAGTTCTTCATCGGCTTACACTGCCAGGCCCTGCAGGACTTGGCAGCTGCTAAGAGAAGCGGAGCACCTGGGGACTCACCGACACATTCCTCCTGCGTG AGCTCTGGGGTAGAGACCAACCCTGAGGACTCAGTGTGCATCCTGGAAGGCTTCTCTGTGACTGCACTTAGCATTCTTCAGCACCTGGTGTGCCACAGCG GAGCAGTCGTCTCCCTATTACTGTCAGGAGTGGGGGCAGATTCTGCTGCTGGGGAAGGAAACAGGAGCCTGGTTCACAGGCTTAGTGATGGAGATATGAC CTCAGCCCTAAGGGGGGTTGCTGATGACCAAGGACAGCACCCACTGTTGAAGATGCTTCTTCACCTGTTGGCTTTCTCTTCTGCAGCAACAGGTCACCTT CAAGCCAGTGTCCTGACCCAGTGCCTTAAGGTTTTGGTGAAATTAGCCGAAAACACTTCCTGTGATTTCTTGCCCAGGTTCCAGTGTGTGTTCCAAGTGC TGCCAAAGTGCCTCAGCCCAGAGACACCCCTGCCTAGCGTGCTGCTGGCTGTTGAGCTCCTCTCCCTGCTGGCGGACCACGACCAGCTGGCACCTCAGCT CTGTTCCCACTCAGAAGGCTGCCTCCTGCTGCTGCTGTACATGTACATCACATCACGGCCTGACAGAGTGGCCTTGGAGACACAATGGCTCCAGCTGGAA CAAGAGGTGGTCAGAGCGCTCACGGTGATGTTGCACAGACAGTGGCTGACAGTGCGGAGGGCAGGGGGACCCCCAAGGACCGACCAGCAGAGGCGGACAG TGCGCTGTCTGCGGGACACGGTGCTGCTGCTGCACGGCCTATCGCAGAAGGACAAGCTCTTCATGATGCACTGCGTGGAGGTCCTGCATCAGTTTGACCA GGTGATGCCGGGGGTCAGCATGCTCATCCGAGGGCTTCCTGATGTGACGGACTGTGAAGAGGCAGCCCTGGATGACCTCTGTGCCGCGGAAACCGATGTG GAAGACCCCGAGGTGGAGTGTGGCTGAGGCCCTGAGTGTCCAGCCACATGGTGGCACCAGCACCACTCCTTTCCTTACCACATCAACTGATTAAAGCAGT GACCAGCAGGAACTGCCCAGAGAACTGGCTGGCCTTGTTTCCTGAGTCTGATCTGTTTGGCGGAGTGGGAGGGGTGGAGCAGGACCCGGACCCTGAGTGG CTGGGATCCTTCTTCCTGTCCCTGGCTGTTGCTGAGCCCGTCCCCATGGTAACTGATCTGCCTTGAGGAAGGAGCCCTGCCCTGCCTGTGGAATTGTCCT GAGTCATTGCTTTGGGCTGGGGCCATGGGAAGAAACCATTGTGTGGCAGGGAAGGAGGTGGCTCTTGGCCCAGGCCTAAACCAGGAAAGCCTGGGAAACT GGGACCCACAGGTGGGCATGAAAGGGCCGCAGCAGGGGCTCCCAGCAGTGTGTAAGACCGGGAGCTGGTCTGGCACCACTGCCCTGGTCCTTCCAGCTGC CTGTCACTGGTATGATGGCCCCGGTGCATTGTGCCACCAGCAGGCCACAGCTGTGGATCTTGGAAGGCCTCTGGGGTCCCCCGGGAGCAGGGGAGTGGGT GTGGGGGGGAACGGATGGTGGTGAGAGGGACAGACCAGGCAGGCTGACGAGCAGGGCGGGCCTGGCTCACGTGGGCCTGTAGGCGGGCCCACGCCAAGTT TCACTTCCCGCCACTGCTGCCAGCGAGAGCCGCGGGAGAGTGTGCAGCCGAGTCACTACTGCCTGCCTGCCTGCCTGCTACGGTGAGTGTGGCCCCCACA ATGGGATGGCGCAGGGCAGGAGGGCCATGGGTTCCCCCACCCCAGACTAAGGGGGCACTAGGGGAGGGGCCGAGTCATGTGAAGAGGGAGACCCTCTCAG ACAGTCGAATGTGCTGGTCCCACTAAGGAAACCACCTCACCCTCTCCAACTTCCTGCCTGAAAATGGGCCCTGGAGCTCGCAGACAGGGCAGGATTGTGC AGGGAAGGCCTGAGATGTGCTTCTGCCCACCCCCTACCCCACTCCCTCCCCTTCGGATCTTAACACTGGGCACTCACACACCCACCCCATGCTCCTCTCC AGGCTCAGCAGCAGGTACGTACCCAACCATGGGCTCGCAGGCCCTGCCCCCGGGGCCCATGCAGACCCTCATCTTTTTCGACATGGAGGCCACTGGCTTG CCCTTCTCCCAGCCCAAGGTCACGGAGCTGTGCCTGCTGGCTGTCCACAGATGTGCCCTGGAGAGCCCCCCCACCTCTCAGGGGCCACCTCCCACAGTTC CTCCACCACCGCGTGTGGTAGACAAGCTCTCCCTGTGTGTGGCTCCGGGGAAGGCCTGCAGCCCTGCAGCCAGCGAGATCACAGGTCTGAGCACAGCTGT GCTGGCAGCGCATGGGCGTCAATGTTTTGATGACAACCTGGCCAACCTGCTCCTAGCCTTCCTGCGGCGCCAGCCACAGCCCTGGTGCCTGGTGGCACAC AATGGTGACCGCTACGACTTCCCCCTGCTCCAAGCAGAGCTGGCTATGCTGGGCCTCACCAGTGCTCTGGATGGTGCCTTCTGTGTGGATAGCATCACTG CGCTGAAGGCCCTGGAGCGAGCAAGCAGCCCCTCAGAACACGGCCCAAGGAAGAGCTACAGCCTAGGCAGCATCTACACTCGCCTGTATGGGCAGTCCCC TCCAGACTCGCACACGGCTGAGGGTGATGTCCTGGCCCTGCTCAGCATCTGTCAGTGGAGACCACAGGCCCTGCTGCGGTGGGTGGATGCTCACGCCAGG CCTTTCGGCACCATCAGGCCCATGTATGGGGTCACAGCCTCTGCTAGGACCAAGCCAAGACCATCTGCTGTCACAACCACTGCACACCTGGCCACAACCA GGAACACTAGTCCCAGCCTTGGAGAGAGCAGGGGTACCAAGGATCTTCCTCCAGTGAAGGACCCTGGAGCCCTATCCAGGGAGGGGCTGCTGGCCCCACT GGGTCTGCTGGCCATCCTGACCTTGGCAGTAGCCACACTGTATGGACTATCCCTGGCCACACCTGGGGAGTAGGCCAAGAAGGAAAATCTGACGAATAAA GACCCCCGCTGCCCCATA

refseq_TREX1.F4 (forward primer)
refseq_TREX1.R4 (reverse primer)
Single exon skipping

Frame 0

ALSDTWGERKAWRGPPRQAARGGASPRRLAPAR RRAPGTPRASGPGASPQPLPRTLTTRSARMGTSL PTTWRSLTPSRHRP*ANVRPRLGTCPVIIRSTD Y*MACQKILQGKTEKLFQLKIISN*RYFRHNTK NLKKR*K*WKKKFSLRMEKLKFCETHYIRRNPF* RNREDHIFFLSKRKPKHSVTRKRNSPKSSNHCS LNSSLKMQR*MN*GQSSRPVNEQINWLLPLFPM SVLGKTLLWL*SQKHVLHNLEKHLFLQRSLLVLT CPFPTPARRSQDTSLWWAERIVSPTV*EVTP*N KKRPRKALLTAGDRDQTLKVPF**TCS*SSL*S QGHP*AFATS*VVVLSLLLAPPCSHQGLAVPWLE CQASGPQVLMMGHFPSQP*EKHRTWHSLD*IWL PGMSAHVMETQQREAEGPSHSASFLEPCISSPL YSSSSAYTARPCRTWQLLREAEHLGTHRHIPPA* ALG*RPTLRTQCASWKASL*LHLAFFSTWCATA EQSSPYYCQEWGQILLLGKETGAWFTGLVMEI* PQP*GGLLMTKDSTHC*RCFFTCWLSLLQQQVTF KPVS*PSALRFW*N*PKTLPVISCPGSSVCSKC CQSASAQRHPCLACCWLLSSSPCWRTTTSWHLS SVPTQKAASCCCCTCTSHHGLTEWPWRHNGSSWN KRWSERSR*CCTDSG*QCGGQGDPQGPTSRGGQ CAVCGTRCCCCTAYRRRTSSS*CTAWRSCISLT R*CRGSACSSEGFLM*RTVKRQPWMTSVPRKPMW KTPRWSVAEALSVQPHGGTSTTPFLTTSTD*SS DQQELPRELAGLVS*V*SVWRSGRGGAGPGP*V AGILLPVPGCC*ARPHGN*SALRKEPCPACGIVL SHCFGLGPWEETIVWQGRRWLLAQA*TRKAWET GTHRWA*KGRSRGSQQCVRPGAGLAPLPWSFQL PVTGMMAPVHCATSRPQLWILEGLWGPPGAGEWV WGGTDGGERDRPGRLTSRAGLAHVGL*AGPRQV SLPATAASESRGRVCSRVTTACLPACYGECGPH NGMAQGRRAMGSPTPD*GGTRGGAESCEEGDPLR QSNVLVPLRKPPHPLQLPA*KWALELADRAGLC REGLRCASAHPLPHSLPFGS*HWALTHPPHAPL QAQQQVRTQPWARRPCPRGPCRPSSFSTWRPLAC PSPSPRSRSCACWLSTDVPWRAPPPLRGHLPQF LHHRVW*TSSPCVWLRGRPAALQPARSQV*AQL CWQRMGVNVLMTTWPTCS*PSCGASHSPGAWWHT MVTATTSPCSKQSWLCWASPVLWMVPSVWIASL R*RPWSEQAAPQNTAQGRATA*AASTLACMGSP LQTRTRLRVMSWPCSASVSGDHRPCCGGWMLTPG LSAPSGPCMGSQPLLGPSQDHLLSQPLHTWPQP GTLVPALERAGVPRIFLQ*RTLEPYPGRGCWPH WVCWPS*PWQ*PHCMDYPWPHLGSRPRRKI*RIK TPAAP

Frame 1

RCRILGVSGKHGGDLRARQQEAERAPGASPRPA AGHRAPPEQAGPGLLRSRCPGP*RPVRRAWGLH CRRPGGA*HPRVTGPEPMSGRGSGRVQ*S*GPQI IRWHVKKSFREKQRNCSN*R*FRIRGTSGTIQR T*RKDESNGRRSSH*EWRN*NFARLTTSDGIRS RGTEKITFSS*ARENPSTQ*QGKGILQKAPIIAV *TPV*RCRDE*IKDKAPDQ*TSK*TGCSLCFPC QS*EKPFCGYKARSMFSTIWKNIFSYKGVF*C* HVPSPPLPDGVRIQASGGQRG**APQSER*LHKT RRGPEKLC*QLETEIKHSRFHFDKPAPEAAFDP RVIPKPLPPPE**F*VSCWHPPAATRVWQYLGW NVRPQDHRFL*WVIFPLSPERSTEPGIHWTESGC PE*VLT*WRPSRGRQKGLPTLPASWSRAFPPPC TVLHRLTLPGPAGLGSC*EKRSTWGLTDTFLLR ELWGRDQP*GLSVHPGRLLCDCT*HSSAPGVPQR SSRLPITVRSGGRFCCWGRKQEPGSQA**WRYD LSPKGGC**PRTAPTVEDASSPVGFLFCSNRSP SSQCPDPVP*GFGEISRKHFL*FLAQVPVCVPSA AKVPQPRDTPA*RAAGC*APLPAGGPRPAGTSA LFPLRRLPPAAAVHVHHITA*QSGLGDTMAPAG TRGGQSAHGDVAQTVADSAEGRGTPKDRPAEADS ALSAGHGAAAARPIAEGQALHDALRGGPASV*P GDAGGQHAHPRAS*CDGL*RGSPG*PLCRGNRC GRPRGGVWLRP*VSSHMVAPAPLLSLPHQLIKAV TSRNCPENWLALFPESDLFGGVGGVEQDPDPEW LGSFFLSLAVAEPVPMVTDLP*GRSPALPVELS *VIALGWGHGKKPLCGREGGGSWPRPKPGKPGKL GPTGGHERAAAGAPSSV*DRELVWHHCPGPSSC LSLV*WPRCIVPPAGHSCGSWKASGVPREQGSG CGGERMVVRGTDQAG*RAGRAWLTWACRRAHAKF HFPPLLPARAAGECAAESLLPACLPATVSVAPT MGWRRAGGPWVPPPQTKGALGEGPSHVKRETLS DSRMCWSH*GNHLTLSNFLPENGPWSSQTGQDCA GKA*DVLLPTPYPTPSPSDLNTGHSHTHPMLLS RLSSRYVPNHGLAGPAPGAHADPHLFRHGGHWL ALLPAQGHGAVPAGCPQMCPGEPPHLSGATSHSS STTACGRQALPVCGSGEGLQPCSQRDHRSEHSC AGSAWASMF**QPGQPAPSLPAAPATALVPGGT QW*PLRLPPAPSRAGYAGPHQCSGWCLLCG*HHC AEGPGASKQPLRTRPKEELQPRQHLHSPVWAVP SRLAHG*G*CPGPAQHLSVETTGPAAVGGCSRQ AFRHHQAHVWGHSLC*DQAKTICCHNHCTPGHNQ EH*SQPWREQGYQGSSSSEGPWSPIQGGAAGPT GSAGHPDLGSSHTVWTIPGHTWGVGQEGKSDE* RPPLPH

Frame 2

AVGYLG*AESMAGTSAPGSKRRSEPPAPRPGPP PGTGHPPSKRARGFSAAAAPDPDDPFGAHGDFT ADDLEELDTLASQALSQCPAAARDVSSDHKVHR LLDGMSKNPSGKNRETVPIKDNFELEVLQAQYKE LKEKMKVMEEEVLIKNGEIKILRDSLHQTESVL EEQRRSHFLLEQEKTQALSDKEKEFSKKLQSLQ SELQFKDAEMNELRTKLQTSERANKLAAPSVSHV SPRKNPSVVIKPEACSPQFGKTSFPTKESFSAN MSLPHPCQTESGYKPLVGREDSKPHSLRGDSIK QEEAQKSFVDSWRQRSNTQGSILINLLLKQPLIP GSSLSLCHLLSSSSESPAGTPLQPPGFGSTLAG MSGLRTTGSYDGSFSLSALREAQNLAFTGLNLV ARNECSRDGDPAEGGRRAFPLCQLPGAVHFLPLV QFFIGLHCQALQDLAAAKRSGAPGDSPTHSSCV SSGVETNPEDSVCILEGFSVTALSILQHLVCHS GAVVSLLLSGVGADSAAGEGNRSLVHRLSDGDMT SALRGVADDQGQHPLLKMLLHLLAFSSAATGHL QASVLTQCLKVLVKLAENTSCDFLPRFQCVFQV LPKCLSPETPLPSVLLAVELLSLLADHDQLAPQL CSHSEGCLLLLLYMYITSRPDRVALETQWLQLE QEVVRALTVMLHRQWLTVRRAGGPPRTDQQRRT VRCLRDTVLLLHGLSQKDKLFMMHCVEVLHQFDQ VMPGVSMLIRGLPDVTDCEEAALDDLCAAETDV EDPEVECG*GPECPATWWHQHHSFPYHIN*LKQ *PAGTAQRTGWPCFLSLICLAEWEGWSRTRTLSG WDPSSCPWLLLSPSPW*LICLEEGALPCLWNCP ESLLWAGAMGRNHCVAGKEVALGPGLNQESLGN WDPQVGMKGPQQGLPAVCKTGSWSGTTALVLPAA CHWYDGPGALCHQQATAVDLGRPLGSPGSRGVG VGGNGWW*EGQTRQADEQGGPGSRGPVGGPTPS FTSRHCCQREPRESVQPSHYCLPACLLR*VWPPQ WDGAGQEGHGFPHPRLRGH*GRGRVM*RGRPSQ TVECAGPTKETTSPSPTSCLKMGPGARRQGRIV QGRPEMCFCPPPTPLPPLRILTLGTHTPTPCSSP GSAAGTYPTMGSQALPPGPMQTLIFFDMEATGL PFSQPKVTELCLLAVHRCALESPPTSQGPPPTV PPPPRVVDKLSLCVAPGKACSPAASEITGLSTAV LAAHGRQCFDDNLANLLLAFLRRQPQPWCLVAH NGDRYDFPLLQAELAMLGLTSALDGAFCVDSIT ALKALERASSPSEHGPRKSYSLGSIYTRLYGQSP PDSHTAEGDVLALLSICQWRPQALLRWVDAHAR PFGTIRPMYGVTASARTKPRPSAVTTTAHLATT RNTSPSLGESRGTKDLPPVKDPGALSREGLLAPL GLLAILTLAVATLYGLSLATPGE*AKKENLTNK DPRCPI

Sequence NM_033628

TGCAGTCTGAACTCCAGTTTAAAGATGCAGAGATGAATGAATTAAGGACAAAGCTCCAGACCAGTGAACGAGCAAATAAACTGGCTGCTCCCTCTGTTTC CCATGTCAGTCCTAGGAAAAACCCTTCTGTGGTTATAAAGCCAGAAGCATGTTCTCCACAATTTGGAAAAACATCTTTTCCTACAAAGGAGTCTTTTAGT GCTAACATGTCCCTTCCCCACCCCTGCCAGACGGAGTCAGGATACAAGCCTCTGGTGGGCAGAGAGGATAGTAAGCCCCACAGTCTGAGAGGTGACTCCA TAAAACAAGAAGAGGCCCAGAAAAGCTTTGTTGACAGCTGGAGACAGAGATCAAACACTCAAGGTTCCATTTTGATAAACCTGCTCCTGAAGCAGCCTTT GATCCCAGGGTCATCCCTAAGCCTTTGCCACCTCCTGAGTAGTAGTTCTGAGTCTCCTGCTGGCACCCCCCTGCAGCCACCAGGGTTTGGCAGTACCTTG GCTGGAATGTCAGGCCTCAGGACCACAGGTTCTTATGATGGGTCATTTTCCCTCTCAGCCCTGAGAGAAGCACAGAACCTGGCATTCACTGGACTGAATC TGGTTGCCCGGAATGAGTGCTCACGTGATGGAGACCCAGCAGAGGGAGGCAGAAGGGCCTTCCCACTCTGCCAGCTTCCTGGAGCCGTGCATTTCCTCCC CCTTGTACAGTTCTTCATCGGCTTACACTGCCAGGCCCTGCAGGACTTGGCAGCTGCTAAGAGAAGCGGAGCACCTGGGGACTCACCGACACATTCCTCC TGCGTGAGCTCTGGGGTAGAGACCAACCCTGAGGACTCAGTGTGCATCCTGGAAGGCTTCTCTGTGACTGCACTTAGCATTCTTCAGCACCTGGTGTGCC ACAGCGGAGCAGTCGTCTCCCTATTACTGTCAGGAGTGGGGGCAGATTCTGCTGCTGGGGAAGGAAACAGGAGCCTGGTTCACAGGCTTAGTGATGGAGA TATGACCTCAGCCCTAAGGGGGGTTGCTGATGACCAAGGACAGCACCCACTGTTGAAGATGCTTCTTCACCTGTTGGCTTTCTCTTCTGCAGCAACAGGT CACCTTCAAGCCAGTGTCCTGACCCAGTGCCTTAAGGTTTTGGTGAAATTAGCCGAAAACACTTCCTGTGATTTCTTGCCCAGGTTCCAGTGTGTGTTCC AAGTGCTGCCAAAGTGCCTCAGCCCAGAGACACCCCTGCCTAGCGTGCTGCTGGCTGTTGAGCTCCTCTCCCTGCTGGCGGACCACGACCAGCTGGCACC TCAGCTCTGTTCCCACTCAGAAGGCTGCCTCCTGCTGCTGCTGTACATGTACATCACATCACGGCCTGACAGAGTGGCCTTGGAGACACAATGGCTCCAG CTGGAACAAGAGGTGGTGTGGCTCCTGGCTAAGCTTGGTGTGCAGAGCCCCTTGCCCCCAGTCACTGGCTCCAACTGCCAGTGTAATGTGGAGGTGGTCA GAGCGCTCACGGTGATGTTGCACAGACAGTGGCTGACAGTGCGGAGGGCAGGGGGACCCCCAAGGACCGACCAGCAGAGGCGGACAGTGCGCTGTCTGCG GGACACGGTGCTGCTGCTGCACGGCCTATCGCAGAAGGACAAGCTCTTCATGATGCACTGCGTGGAGGTCCTGCATCAGTTTGACCAGGTGATGCCGGGG GTCAGCATGCTCATCCGAGGGCTTCCTGATGTGACGGACTGTGAAGAGGCAGCCCTGGATGACCTCTGTGCCGCGGAAACCGATGTGGAAGACCCCGAGG TGGAGTGTGGCTGAGGCCCTGAGTGTCCAGCCACATGGTGGCACCAGCACCACTCCTTTCCTTACCACATCAACTGATTAAAGCAGTGACCAGCAGGAAC TGCCCAGAGAACTGGCTGGCCTTGTTTCCTGAGTCTGATCTGTTTGGCGGAGTGGGAGGGGTGGAGCAGGACCCGGACCCTGAGTGGCTGGGATCCTTCT TCCTGTCCCTGGCTGTTGCTGAGCCCGTCCCCATGGTAACTGATCTGCCTTGAGGAAGGAGCCCTGCCCTGCCTGTGGAATTGTCCTGAGTCATTGCTTT GGGCTGGGGCCATGGGAAGAAACCATTGTGTGGCAGGGAAGGAGGTGGCTCTTGGCCCAGGCCTAAACCAGGAAAGCCTGGGAAACTGGGACCCACAGGT GGGCATGAAAGGGCCGCAGCAGGGGCTCCCAGCAGTGTGTAAGACCGGGAGCTGGTCTGGCACCACTGCCCTGGTCCTTCCAGCTGCCTGTCACTGGTAT GATGGCCCCGGTGCATTGTGCCACCAGCAGGCCACAGCTGTGGATCTTGGAAGGCCTCTGGGGTCCCCCGGGAGCAGGGGAGTGGGTGTGGGGGGGAACG GATGGTGGTGAGAGGGACAGACCAGGCAGGCTGACGAGCAGGGCGGGCCTGGCTCACGTGGGCCTGTAGGCGGGCCCACGCCAAGTTTCACTTCCCGCCA CTGCTGCCAGCGAGAGCCGCGGGAGAGTGTGCAGCCGAGTCACTACTGCCTGCCTGCCTGCCTGCTACGGCTCAGCAGCAGGTACGTACCCAACCATGGG CTCGCAGGCCCTGCCCCCGGGGCCCATGCAGACCCTCATCTTTTTCGACATGGAGGCCACTGGCTTGCCCTTCTCCCAGCCCAAGGTCACGGAGCTGTGC CTGCTGGCTGTCCACAGATGTGCCCTGGAGAGCCCCCCCACCTCTCAGGGGCCACCTCCCACAGTTCCTCCACCACCGCGTGTGGTAGACAAGCTCTCCC TGTGTGTGGCTCCGGGGAAGGCCTGCAGCCCTGCAGCCAGCGAGATCACAGGTCTGAGCACAGCTGTGCTGGCAGCGCATGGGCGTCAATGTTTTGATGA CAACCTGGCCAACCTGCTCCTAGCCTTCCTGCGGCGCCAGCCACAGCCCTGGTGCCTGGTGGCACACAATGGTGACCGCTACGACTTCCCCCTGCTCCAA GCAGAGCTGGCTATGCTGGGCCTCACCAGTGCTCTGGATGGTGCCTTCTGTGTGGATAGCATCACTGCGCTGAAGGCCCTGGAGCGAGCAAGCAGCCCCT CAGAACACGGCCCAAGGAAGAGCTACAGCCTAGGCAGCATCTACACTCGCCTGTATGGGCAGTCCCCTCCAGACTCGCACACGGCTGAGGGTGATGTCCT GGCCCTGCTCAGCATCTGTCAGTGGAGACCACAGGCCCTGCTGCGGTGGGTGGATGCTCACGCCAGGCCTTTCGGCACCATCAGGCCCATGTATGGGGTC ACAGCCTCTGCTAGGACCAAGCCAAGACCATCTGCTGTCACAACCACTGCACACCTGGCCACAACCAGGAACACTAGTCCCAGCCTTGGAGAGAGCAGGG GTACCAAGGATCTTCCTCCAGTGAAGGACCCTGGAGCCCTATCCAGGGAGGGGCTGCTGGCCCCACTGGGTCTGCTGGCCATCCTGACCTTGGCAGTAGC CACACTGTATGGACTATCCCTGGCCACACCTGGGGAGTAGGCCAAGAAGGAAAATCTGACGAATAAAGACCCCCGCTGCCCCATA

refseq_TREX1.F4 (forward primer)
refseq_TREX1.R4 (reverse primer)
Single exon skipping

Frame 0

CSLNSSLKMQR*MN*GQSSRPVNEQINWLLPLF PMSVLGKTLLWL*SQKHVLHNLEKHLFLQRSLLV LTCPFPTPARRSQDTSLWWAERIVSPTV*EVTP *NKKRPRKALLTAGDRDQTLKVPF**TCS*SSL *SQGHP*AFATS*VVVLSLLLAPPCSHQGLAVPW LECQASGPQVLMMGHFPSQP*EKHRTWHSLD*I WLPGMSAHVMETQQREAEGPSHSASFLEPCISS PLYSSSSAYTARPCRTWQLLREAEHLGTHRHIPP A*ALG*RPTLRTQCASWKASL*LHLAFFSTWCA TAEQSSPYYCQEWGQILLLGKETGAWFTGLVME I*PQP*GGLLMTKDSTHC*RCFFTCWLSLLQQQV TFKPVS*PSALRFW*N*PKTLPVISCPGSSVCS KCCQSASAQRHPCLACCWLLSSSPCWRTTTSWH LSSVPTQKAASCCCCTCTSHHGLTEWPWRHNGSS WNKRWCGSWLSLVCRAPCPQSLAPTASVMWRWS ERSR*CCTDSG*QCGGQGDPQGPTSRGGQCAVC GTRCCCCTAYRRRTSSS*CTAWRSCISLTR*CRG SACSSEGFLM*RTVKRQPWMTSVPRKPMWKTPR WSVAEALSVQPHGGTSTTPFLTTSTD*SSDQQE LPRELAGLVS*V*SVWRSGRGGAGPGP*VAGILL PVPGCC*ARPHGN*SALRKEPCPACGIVLSHCF GLGPWEETIVWQGRRWLLAQA*TRKAWETGTHR WA*KGRSRGSQQCVRPGAGLAPLPWSFQLPVTGM MAPVHCATSRPQLWILEGLWGPPGAGEWVWGGT DGGERDRPGRLTSRAGLAHVGL*AGPRQVSLPA TAASESRGRVCSRVTTACLPACYGSAAGTYPTMG SQALPPGPMQTLIFFDMEATGLPFSQPKVTELC LLAVHRCALESPPTSQGPPPTVPPPPRVVDKLS LCVAPGKACSPAASEITGLSTAVLAAHGRQCFDD NLANLLLAFLRRQPQPWCLVAHNGDRYDFPLLQ AELAMLGLTSALDGAFCVDSITALKALERASSP SEHGPRKSYSLGSIYTRLYGQSPPDSHTAEGDVL ALLSICQWRPQALLRWVDAHARPFGTIRPMYGV TASARTKPRPSAVTTTAHLATTRNTSPSLGESR GTKDLPPVKDPGALSREGLLAPLGLLAILTLAVA TLYGLSLATPGE*AKKENLTNKDPRCPI

Frame 1

AV*TPV*RCRDE*IKDKAPDQ*TSK*TGCSLCF PCQS*EKPFCGYKARSMFSTIWKNIFSYKGVF* C*HVPSPPLPDGVRIQASGGQRG**APQSER*LH KTRRGPEKLC*QLETEIKHSRFHFDKPAPEAAF DPRVIPKPLPPPE**F*VSCWHPPAATRVWQYL GWNVRPQDHRFL*WVIFPLSPERSTEPGIHWTES GCPE*VLT*WRPSRGRQKGLPTLPASWSRAFPP PCTVLHRLTLPGPAGLGSC*EKRSTWGLTDTFL LRELWGRDQP*GLSVHPGRLLCDCT*HSSAPGVP QRSSRLPITVRSGGRFCCWGRKQEPGSQA**WR YDLSPKGGC**PRTAPTVEDASSPVGFLFCSNR SPSSQCPDPVP*GFGEISRKHFL*FLAQVPVCVP SAAKVPQPRDTPA*RAAGC*APLPAGGPRPAGT SALFPLRRLPPAAAVHVHHITA*QSGLGDTMAP AGTRGGVAPG*AWCAEPLAPSHWLQLPV*CGGGQ SAHGDVAQTVADSAEGRGTPKDRPAEADSALSA GHGAAAARPIAEGQALHDALRGGPASV*PGDAG GQHAHPRAS*CDGL*RGSPG*PLCRGNRCGRPRG GVWLRP*VSSHMVAPAPLLSLPHQLIKAVTSRN CPENWLALFPESDLFGGVGGVEQDPDPEWLGSF FLSLAVAEPVPMVTDLP*GRSPALPVELS*VIAL GWGHGKKPLCGREGGGSWPRPKPGKPGKLGPTG GHERAAAGAPSSV*DRELVWHHCPGPSSCLSLV *WPRCIVPPAGHSCGSWKASGVPREQGSGCGGER MVVRGTDQAG*RAGRAWLTWACRRAHAKFHFPP LLPARAAGECAAESLLPACLPATAQQQVRTQPW ARRPCPRGPCRPSSFSTWRPLACPSPSPRSRSCA CWLSTDVPWRAPPPLRGHLPQFLHHRVW*TSSP CVWLRGRPAALQPARSQV*AQLCWQRMGVNVLM TTWPTCS*PSCGASHSPGAWWHTMVTATTSPCSK QSWLCWASPVLWMVPSVWIASLR*RPWSEQAAP QNTAQGRATA*AASTLACMGSPLQTRTRLRVMS WPCSASVSGDHRPCCGGWMLTPGLSAPSGPCMGS QPLLGPSQDHLLSQPLHTWPQPGTLVPALERAG VPRIFLQ*RTLEPYPGRGCWPHWVCWPS*PWQ* PHCMDYPWPHLGSRPRRKI*RIKTPAAP

Frame 2

QSELQFKDAEMNELRTKLQTSERANKLAAPSVS HVSPRKNPSVVIKPEACSPQFGKTSFPTKESFS ANMSLPHPCQTESGYKPLVGREDSKPHSLRGDS IKQEEAQKSFVDSWRQRSNTQGSILINLLLKQPL IPGSSLSLCHLLSSSSESPAGTPLQPPGFGSTL AGMSGLRTTGSYDGSFSLSALREAQNLAFTGLN LVARNECSRDGDPAEGGRRAFPLCQLPGAVHFLP LVQFFIGLHCQALQDLAAAKRSGAPGDSPTHSS CVSSGVETNPEDSVCILEGFSVTALSILQHLVC HSGAVVSLLLSGVGADSAAGEGNRSLVHRLSDGD MTSALRGVADDQGQHPLLKMLLHLLAFSSAATG HLQASVLTQCLKVLVKLAENTSCDFLPRFQCVF QVLPKCLSPETPLPSVLLAVELLSLLADHDQLAP QLCSHSEGCLLLLLYMYITSRPDRVALETQWLQ LEQEVVWLLAKLGVQSPLPPVTGSNCQCNVEVV RALTVMLHRQWLTVRRAGGPPRTDQQRRTVRCLR DTVLLLHGLSQKDKLFMMHCVEVLHQFDQVMPG VSMLIRGLPDVTDCEEAALDDLCAAETDVEDPE VECG*GPECPATWWHQHHSFPYHIN*LKQ*PAGT AQRTGWPCFLSLICLAEWEGWSRTRTLSGWDPS SCPWLLLSPSPW*LICLEEGALPCLWNCPESLL WAGAMGRNHCVAGKEVALGPGLNQESLGNWDPQV GMKGPQQGLPAVCKTGSWSGTTALVLPAACHWY DGPGALCHQQATAVDLGRPLGSPGSRGVGVGGN GWW*EGQTRQADEQGGPGSRGPVGGPTPSFTSRH CCQREPRESVQPSHYCLPACLLRLSSRYVPNHG LAGPAPGAHADPHLFRHGGHWLALLPAQGHGAV PAGCPQMCPGEPPHLSGATSHSSSTTACGRQALP VCGSGEGLQPCSQRDHRSEHSCAGSAWASMF** QPGQPAPSLPAAPATALVPGGTQW*PLRLPPAP SRAGYAGPHQCSGWCLLCG*HHCAEGPGASKQPL RTRPKEELQPRQHLHSPVWAVPSRLAHG*G*CP GPAQHLSVETTGPAAVGGCSRQAFRHHQAHVWG HSLC*DQAKTICCHNHCTPGHNQEH*SQPWREQG YQGSSSSEGPWSPIQGGAAGPTGSAGHPDLGSS HTVWTIPGHTWGVGQEGKSDE*RPPLPH

Sequence NM_130384

GCGCTGTCGGATACTTGGGGTGAGCGGAAAGCATGGCGGGGACCTCCGCGCCAGGCAGCAAGAGGCGGAGCGAGCCCCCGGCGCCTCGCCCCGGCCCGCC GCCGGGCACCGGGCACCCCCCGAGCAAGCGGGCCCGGGGCTTCTCCGCAGCCGCTGCCCCGGACCCTGACGACCCGTTCGGCGCGCATGGGGACTTCACT GCCGACGACCTGGAGGAGCTTGACACCCTCGCGTCACAGGCCCTGAGCCAATGTCCGGCCGCGGCTCGGGACGTGTCCAGTGATCATAAGGTCCACAGAT TATTAGATGGCATGTCAAAAAATCCTTCAGGGAAAAACAGAGAAACTGTTCCAATTAAAGATAATTTCGAATTAGAGGTACTTCAGGCACAATACAAAGA ACTTAAAGAAAAGATGAAAGTAATGGAAGAAGAAGTTCTCATTAAGAATGGAGAAATTAAAATTTTGCGAGACTCACTACATCAGACGGAATCCGTTCTA GAGGAACAGAGAAGATCACATTTTCTTCTTGAGCAAGAGAAAACCCAAGCACTCAGTGACAAGGAAAAGGAATTCTCCAAAAAGCTCCAATCATTGCAGT CTGAACTCCAGTTTAAAGATGCAGAGATGAATGAATTAAGGACAAAGCTCCAGACCAGTGAACGAGCAAATAAACTGGCTGCTCCCTCTGTTTCCCATGT CAGTCCTAGGAAAAACCCTTCTGTGGTTATAAAGCCAGAAGCATGTTCTCCACAATTTGGAAAAACATCTTTTCCTACAAAGGAGTCTTTTAGTGCTAAC ATGTCCCTTCCCCACCCCTGCCAGACGGAGTCAGGATACAAGCCTCTGGTGGGCAGAGAGGATAGTAAGCCCCACAGTCTGAGAGGTGACTCCATAAAAC AAGAAGAGGCCCAGAAAAGCTTTGTTGACAGCTGGAGACAGAGATCAAACACTCAAGGTTCCATTTTGATAAACCTGCTCCTGAAGCAGCCTTTGATCCC AGGGTCATCCCTAAGCCTTTGCCACCTCCTGAGTAGTAGTTCTGAGTCTCCTGCTGGCACCCCCCTGCAGCCACCAGGGTTTGGCAGTACCTTGGCTGGA ATGTCAGGCCTCAGGACCACAGGTTCTTATGATGGGTCATTTTCCCTCTCAGCCCTGAGAGAAGCACAGAACCTGGCATTCACTGGACTGAATCTGGTTG CCCGGAATGAGTGCTCACGTGATGGAGACCCAGCAGAGGGAGGCAGAAGGGCCTTCCCACTCTGCCAGCTTCCTGGAGCCGTGCATTTCCTCCCCCTTGT ACAGTTCTTCATCGGCTTACACTGCCAGGCCCTGCAGGACTTGGCAGCTGCTAAGAGAAGCGGAGCACCTGGGGACTCACCGACACATTCCTCCTGCGTG AGCTCTGGGGTAGAGACCAACCCTGAGGACTCAGTGTGCATCCTGGAAGGCTTCTCTGTGACTGCACTTAGCATTCTTCAGCACCTGGTGTGCCACAGCG GAGCAGTCGTCTCCCTATTACTGTCAGGAGTGGGGGCAGATTCTGCTGCTGGGGAAGGAAACAGGAGCCTGGTTCACAGGCTTAGTGATGGAGATATGAC CTCAGCCCTAAGGGGGGTTGCTGATGACCAAGGACAGCACCCACTGTTGAAGATGCTTCTTCACCTGTTGGCTTTCTCTTCTGCAGCAACAGGTCACCTT CAAGCCAGTGTCCTGACCCAGTGCCTTAAGGTTTTGGTGAAATTAGCCGAAAACACTTCCTGTGATTTCTTGCCCAGGTTCCAGTGTGTGTTCCAAGTGC TGCCAAAGTGCCTCAGCCCAGAGACACCCCTGCCTAGCGTGCTGCTGGCTGTTGAGCTCCTCTCCCTGCTGGCGGACCACGACCAGCTGGCACCTCAGCT CTGTTCCCACTCAGAAGGCTGCCTCCTGCTGCTGCTGTACATGTACATCACATCACGGCCTGACAGAGTGGCCTTGGAGACACAATGGCTCCAGCTGGAA CAAGAGGTGGTGTGGCTCCTGGCTAAGCTTGGTGTGCAGAGCCCCTTGCCCCCAGTCACTGGCTCCAACTGCCAGTGTAATGTGGAGGTGGTCAGAGCGC TCACGGTGATGTTGCACAGACAGTGGCTGACAGTGCGGAGGGCAGGGGGACCCCCAAGGACCGACCAGCAGAGGCGGACAGTGCGCTGTCTGCGGGACAC GGTGCTGCTGCTGCACGGCCTATCGCAGAAGGACAAGCTCTTCATGATGCACTGCGTGGAGGTCCTGCATCAGTTTGACCAGGTGATGCCGGGGGTCAGC ATGCTCATCCGAGGGCTTCCTGATGTGACGGACTGTGAAGAGGCAGCCCTGGATGACCTCTGTGCCGCGGAAACCGATGTGGAAGACCCCGAGGTGGAGT GTGGCTGAGGCCCTGAGTGTCCAGCCACATGGTGGCACCAGCACCACTCCTTTCCTTACCACATCAACTGATTAAAGCAGTGACCAGCAGGAACTGCCCA GAGAACTGGCTGGCCTTGTTTCCTGAGTCTGATCTGTTTGGCGGAGTGGGAGGGGTGGAGCAGGACCCGGACCCTGAGTGGCTGGGATCCTTCTTCCTGT CCCTGGCTGTTGCTGAGCCCGTCCCCATGGTAACTGATCTGCCTTGAGGAAGGAGCCCTGCCCTGCCTGTGGAATTGTCCTGAGTCATTGCTTTGGGCTG GGGCCATGGGAAGAAACCATTGTGTGGCAGGGAAGGAGGTGGCTCTTGGCCCAGGCCTAAACCAGGAAAGCCTGGGAAACTGGGACCCACAGGTGGGCAT GAAAGGGCCGCAGCAGGGGCTCCCAGCAGTGTGTAAGACCGGGAGCTGGTCTGGCACCACTGCCCTGGTCCTTCCAGCTGCCTGTCACTGGTATGATGGC CCCGGTGCATTGTGCCACCAGCAGGCCACAGCTGTGGATCTTGGAAGGCCTCTGGGGTCCCCCGGGAGCAGGGGAGTGGGTGTGGGGGGGAACGGATGGT GGTGAGAGGGACAGACCAGGCAGGCTGACGAGCAGGGCGGGCCTGGCTCACGTGGGCCTGTAGGCGGGCCCACGCCAAGTTTCACTTCCCGCCACTGCTG CCAGCGAGAGCCGCGGGAGAGTGTGCAGCCGAGTCACTACTGCCTGCCTGCCTGCCTGCTACGGTGAGTGTGGCCCCCACAATGGGATGGCGCAGGGCAG GAGGGCCATGGGTTCCCCCACCCCAGACTAAGGGGGCACTAGGGGAGGGGCCGAGTCATGTGAAGAGGGAGACCCTCTCAGACAGTCGAATGTGCTGGTC CCACTAAGGAAACCACCTCACCCTCTCCAACTTCCTGCCTGAAAATGGGCCCTGGAGCTCGCAGACAGGGCAGGATTGTGCAGGGAAGGCCTGAGATGTG CTTCTGCCCACCCCCTACCCCACTCCCTCCCCTTCGGATCTTAACACTGGGCACTCACACACCCACCCCATGCTCCTCTCCAGGCTCAGCAGCAGGTACG TACCCAACCATGGGCTCGCAGGCCCTGCCCCCGGGGCCCATGCAGACCCTCATCTTTTTCGACATGGAGGCCACTGGCTTGCCCTTCTCCCAGCCCAAGG TCACGGAGCTGTGCCTGCTGGCTGTCCACAGATGTGCCCTGGAGAGCCCCCCCACCTCTCAGGGGCCACCTCCCACAGTTCCTCCACCACCGCGTGTGGT AGACAAGCTCTCCCTGTGTGTGGCTCCGGGGAAGGCCTGCAGCCCTGCAGCCAGCGAGATCACAGGTCTGAGCACAGCTGTGCTGGCAGCGCATGGGCGT CAATGTTTTGATGACAACCTGGCCAACCTGCTCCTAGCCTTCCTGCGGCGCCAGCCACAGCCCTGGTGCCTGGTGGCACACAATGGTGACCGCTACGACT TCCCCCTGCTCCAAGCAGAGCTGGCTATGCTGGGCCTCACCAGTGCTCTGGATGGTGCCTTCTGTGTGGATAGCATCACTGCGCTGAAGGCCCTGGAGCG AGCAAGCAGCCCCTCAGAACACGGCCCAAGGAAGAGCTACAGCCTAGGCAGCATCTACACTCGCCTGTATGGGCAGTCCCCTCCAGACTCGCACACGGCT GAGGGTGATGTCCTGGCCCTGCTCAGCATCTGTCAGTGGAGACCACAGGCCCTGCTGCGGTGGGTGGATGCTCACGCCAGGCCTTTCGGCACCATCAGGC CCATGTATGGGGTCACAGCCTCTGCTAGGACCAAGCCAAGACCATCTGCTGTCACAACCACTGCACACCTGGCCACAACCAGGAACACTAGTCCCAGCCT TGGAGAGAGCAGGGGTACCAAGGATCTTCCTCCAGTGAAGGACCCTGGAGCCCTATCCAGGGAGGGGCTGCTGGCCCCACTGGGTCTGCTGGCCATCCTG ACCTTGGCAGTAGCCACACTGTATGGACTATCCCTGGCCACACCTGGGGAGTAGGCCAAGAAGGAAAATCTGACGAATAAAGACCCCCGCTGCCCCATA

refseq_TREX1.F4 (forward primer)
refseq_TREX1.R4 (reverse primer)
Single exon skipping

Frame 0

ALSDTWGERKAWRGPPRQAARGGASPRRLAPAR RRAPGTPRASGPGASPQPLPRTLTTRSARMGTSL PTTWRSLTPSRHRP*ANVRPRLGTCPVIIRSTD Y*MACQKILQGKTEKLFQLKIISN*RYFRHNTK NLKKR*K*WKKKFSLRMEKLKFCETHYIRRNPF* RNREDHIFFLSKRKPKHSVTRKRNSPKSSNHCS LNSSLKMQR*MN*GQSSRPVNEQINWLLPLFPM SVLGKTLLWL*SQKHVLHNLEKHLFLQRSLLVLT CPFPTPARRSQDTSLWWAERIVSPTV*EVTP*N KKRPRKALLTAGDRDQTLKVPF**TCS*SSL*S QGHP*AFATS*VVVLSLLLAPPCSHQGLAVPWLE CQASGPQVLMMGHFPSQP*EKHRTWHSLD*IWL PGMSAHVMETQQREAEGPSHSASFLEPCISSPL YSSSSAYTARPCRTWQLLREAEHLGTHRHIPPA* ALG*RPTLRTQCASWKASL*LHLAFFSTWCATA EQSSPYYCQEWGQILLLGKETGAWFTGLVMEI* PQP*GGLLMTKDSTHC*RCFFTCWLSLLQQQVTF KPVS*PSALRFW*N*PKTLPVISCPGSSVCSKC CQSASAQRHPCLACCWLLSSSPCWRTTTSWHLS SVPTQKAASCCCCTCTSHHGLTEWPWRHNGSSWN KRWCGSWLSLVCRAPCPQSLAPTASVMWRWSER SR*CCTDSG*QCGGQGDPQGPTSRGGQCAVCGT RCCCCTAYRRRTSSS*CTAWRSCISLTR*CRGSA CSSEGFLM*RTVKRQPWMTSVPRKPMWKTPRWS VAEALSVQPHGGTSTTPFLTTSTD*SSDQQELP RELAGLVS*V*SVWRSGRGGAGPGP*VAGILLPV PGCC*ARPHGN*SALRKEPCPACGIVLSHCFGL GPWEETIVWQGRRWLLAQA*TRKAWETGTHRWA *KGRSRGSQQCVRPGAGLAPLPWSFQLPVTGMMA PVHCATSRPQLWILEGLWGPPGAGEWVWGGTDG GERDRPGRLTSRAGLAHVGL*AGPRQVSLPATA ASESRGRVCSRVTTACLPACYGECGPHNGMAQGR RAMGSPTPD*GGTRGGAESCEEGDPLRQSNVLV PLRKPPHPLQLPA*KWALELADRAGLCREGLRC ASAHPLPHSLPFGS*HWALTHPPHAPLQAQQQVR TQPWARRPCPRGPCRPSSFSTWRPLACPSPSPR SRSCACWLSTDVPWRAPPPLRGHLPQFLHHRVW *TSSPCVWLRGRPAALQPARSQV*AQLCWQRMGV NVLMTTWPTCS*PSCGASHSPGAWWHTMVTATT SPCSKQSWLCWASPVLWMVPSVWIASLR*RPWS EQAAPQNTAQGRATA*AASTLACMGSPLQTRTRL RVMSWPCSASVSGDHRPCCGGWMLTPGLSAPSG PCMGSQPLLGPSQDHLLSQPLHTWPQPGTLVPA LERAGVPRIFLQ*RTLEPYPGRGCWPHWVCWPS* PWQ*PHCMDYPWPHLGSRPRRKI*RIKTPAAP

Frame 1

RCRILGVSGKHGGDLRARQQEAERAPGASPRPA AGHRAPPEQAGPGLLRSRCPGP*RPVRRAWGLH CRRPGGA*HPRVTGPEPMSGRGSGRVQ*S*GPQI IRWHVKKSFREKQRNCSN*R*FRIRGTSGTIQR T*RKDESNGRRSSH*EWRN*NFARLTTSDGIRS RGTEKITFSS*ARENPSTQ*QGKGILQKAPIIAV *TPV*RCRDE*IKDKAPDQ*TSK*TGCSLCFPC QS*EKPFCGYKARSMFSTIWKNIFSYKGVF*C* HVPSPPLPDGVRIQASGGQRG**APQSER*LHKT RRGPEKLC*QLETEIKHSRFHFDKPAPEAAFDP RVIPKPLPPPE**F*VSCWHPPAATRVWQYLGW NVRPQDHRFL*WVIFPLSPERSTEPGIHWTESGC PE*VLT*WRPSRGRQKGLPTLPASWSRAFPPPC TVLHRLTLPGPAGLGSC*EKRSTWGLTDTFLLR ELWGRDQP*GLSVHPGRLLCDCT*HSSAPGVPQR SSRLPITVRSGGRFCCWGRKQEPGSQA**WRYD LSPKGGC**PRTAPTVEDASSPVGFLFCSNRSP SSQCPDPVP*GFGEISRKHFL*FLAQVPVCVPSA AKVPQPRDTPA*RAAGC*APLPAGGPRPAGTSA LFPLRRLPPAAAVHVHHITA*QSGLGDTMAPAG TRGGVAPG*AWCAEPLAPSHWLQLPV*CGGGQSA HGDVAQTVADSAEGRGTPKDRPAEADSALSAGH GAAAARPIAEGQALHDALRGGPASV*PGDAGGQ HAHPRAS*CDGL*RGSPG*PLCRGNRCGRPRGGV WLRP*VSSHMVAPAPLLSLPHQLIKAVTSRNCP ENWLALFPESDLFGGVGGVEQDPDPEWLGSFFL SLAVAEPVPMVTDLP*GRSPALPVELS*VIALGW GHGKKPLCGREGGGSWPRPKPGKPGKLGPTGGH ERAAAGAPSSV*DRELVWHHCPGPSSCLSLV*W PRCIVPPAGHSCGSWKASGVPREQGSGCGGERMV VRGTDQAG*RAGRAWLTWACRRAHAKFHFPPLL PARAAGECAAESLLPACLPATVSVAPTMGWRRA GGPWVPPPQTKGALGEGPSHVKRETLSDSRMCWS H*GNHLTLSNFLPENGPWSSQTGQDCAGKA*DV LLPTPYPTPSPSDLNTGHSHTHPMLLSRLSSRY VPNHGLAGPAPGAHADPHLFRHGGHWLALLPAQG HGAVPAGCPQMCPGEPPHLSGATSHSSSTTACG RQALPVCGSGEGLQPCSQRDHRSEHSCAGSAWA SMF**QPGQPAPSLPAAPATALVPGGTQW*PLRL PPAPSRAGYAGPHQCSGWCLLCG*HHCAEGPGA SKQPLRTRPKEELQPRQHLHSPVWAVPSRLAHG *G*CPGPAQHLSVETTGPAAVGGCSRQAFRHHQA HVWGHSLC*DQAKTICCHNHCTPGHNQEH*SQP WREQGYQGSSSSEGPWSPIQGGAAGPTGSAGHP DLGSSHTVWTIPGHTWGVGQEGKSDE*RPPLPH

Frame 2

AVGYLG*AESMAGTSAPGSKRRSEPPAPRPGPP PGTGHPPSKRARGFSAAAAPDPDDPFGAHGDFT ADDLEELDTLASQALSQCPAAARDVSSDHKVHR LLDGMSKNPSGKNRETVPIKDNFELEVLQAQYKE LKEKMKVMEEEVLIKNGEIKILRDSLHQTESVL EEQRRSHFLLEQEKTQALSDKEKEFSKKLQSLQ SELQFKDAEMNELRTKLQTSERANKLAAPSVSHV SPRKNPSVVIKPEACSPQFGKTSFPTKESFSAN MSLPHPCQTESGYKPLVGREDSKPHSLRGDSIK QEEAQKSFVDSWRQRSNTQGSILINLLLKQPLIP GSSLSLCHLLSSSSESPAGTPLQPPGFGSTLAG MSGLRTTGSYDGSFSLSALREAQNLAFTGLNLV ARNECSRDGDPAEGGRRAFPLCQLPGAVHFLPLV QFFIGLHCQALQDLAAAKRSGAPGDSPTHSSCV SSGVETNPEDSVCILEGFSVTALSILQHLVCHS GAVVSLLLSGVGADSAAGEGNRSLVHRLSDGDMT SALRGVADDQGQHPLLKMLLHLLAFSSAATGHL QASVLTQCLKVLVKLAENTSCDFLPRFQCVFQV LPKCLSPETPLPSVLLAVELLSLLADHDQLAPQL CSHSEGCLLLLLYMYITSRPDRVALETQWLQLE QEVVWLLAKLGVQSPLPPVTGSNCQCNVEVVRA LTVMLHRQWLTVRRAGGPPRTDQQRRTVRCLRDT VLLLHGLSQKDKLFMMHCVEVLHQFDQVMPGVS MLIRGLPDVTDCEEAALDDLCAAETDVEDPEVE CG*GPECPATWWHQHHSFPYHIN*LKQ*PAGTAQ RTGWPCFLSLICLAEWEGWSRTRTLSGWDPSSC PWLLLSPSPW*LICLEEGALPCLWNCPESLLWA GAMGRNHCVAGKEVALGPGLNQESLGNWDPQVGM KGPQQGLPAVCKTGSWSGTTALVLPAACHWYDG PGALCHQQATAVDLGRPLGSPGSRGVGVGGNGW W*EGQTRQADEQGGPGSRGPVGGPTPSFTSRHCC QREPRESVQPSHYCLPACLLR*VWPPQWDGAGQ EGHGFPHPRLRGH*GRGRVM*RGRPSQTVECAG PTKETTSPSPTSCLKMGPGARRQGRIVQGRPEMC FCPPPTPLPPLRILTLGTHTPTPCSSPGSAAGT YPTMGSQALPPGPMQTLIFFDMEATGLPFSQPK VTELCLLAVHRCALESPPTSQGPPPTVPPPPRVV DKLSLCVAPGKACSPAASEITGLSTAVLAAHGR QCFDDNLANLLLAFLRRQPQPWCLVAHNGDRYD FPLLQAELAMLGLTSALDGAFCVDSITALKALER ASSPSEHGPRKSYSLGSIYTRLYGQSPPDSHTA EGDVLALLSICQWRPQALLRWVDAHARPFGTIR PMYGVTASARTKPRPSAVTTTAHLATTRNTSPSL GESRGTKDLPPVKDPGALSREGLLAPLGLLAIL TLAVATLYGLSLATPGE*AKKENLTNKDPRCPI

Sequence NM_033627

GCGCTGTCGGATACTTGGGGTGAGCGGAAAGCATGGCGGGGACCTCCGCGCCAGGCAGCAAGAGGCGGAGCGAGCCCCCGGCGCCTCGCCCCGGCCCGCC GCCGGGCACCGGGCACCCCCCGAGCAAGCGGGCCCGGGGCTTCTCCGCAGCCGCTGCCCCGGACCCTGACGACCCGTTCGGCGCGCATGGGGACTTCACT GCCGACGACCTGGAGGAGCTTGACACCCTCGCGTCACAGGCCCTGAGCCAATGTCCGGCCGCGGCTCGGGACGTGTCCAGTGATCATAAGGTCCACAGAT TATTAGATGGCATGTCAAAAAATCCTTCAGGGAAAAACAGAGAAACTGTTCCAATTAAAGATAATTTCGAATTAGAGGTACTTCAGGCACAATACAAAGA ACTTAAAGAAAAGATGAAAGTAATGGAAGAAGAAGTTCTCATTAAGAATGGAGAAATTAAAATTTTGCGAGACTCACTACATCAGACGGAATCCGTTCTA GAGGAACAGAGAAGATCACATTTTCTTCTTGAGCAAGAGAAAACCCAAGCACTCAGTGACAAGGAAAAGGAATTCTCCAAAAAGCTCCAATCATTGCAGT CTGAACTCCAGTTTAAAGATGCAGAGATGAATGAATTAAGGACAAAGCTCCAGACCAGTGAACGAGCAAATAAACTGGCTGCTCCCTCTGTTTCCCATGT CAGTCCTAGGAAAAACCCTTCTGTGGTTATAAAGCCAGAAGCATGTTCTCCACAATTTGGAAAAACATCTTTTCCTACAAAGGAGTCTTTTAGTGCTAAC ATGTCCCTTCCCCACCCCTGCCAGACGGAGTCAGGATACAAGCCTCTGGTGGGCAGAGAGGATAGTAAGCCCCACAGTCTGAGAGGTGACTCCATAAAAC AAGAAGAGGCCCAGAAAAGCTTTGTTGACAGCTGGAGACAGAGATCAAACACTCAAGGTTCCATTTTGATAAACCTGCTCCTGAAGCAGCCTTTGATCCC AGGGTCATCCCTAAGCCTTTGCCACCTCCTGAGTAGTAGTTCTGAGTCTCCTGCTGGCACCCCCCTGCAGCCACCAGGGTTTGGCAGTACCTTGGCTGGA ATGTCAGGCCTCAGGACCACAGGTTCTTATGATGGGTCATTTTCCCTCTCAGCCCTGAGAGAAGCACAGAACCTGGCATTCACTGGACTGAATCTGGTTG CCCGGAATGAGTGCTCACGTGATGGAGACCCAGCAGAGGGAGGCAGAAGGGCCTTCCCACTCTGCCAGCTTCCTGGAGCCGTGCATTTCCTCCCCCTTGT ACAGTTCTTCATCGGCTTACACTGCCAGGCCCTGCAGGACTTGGCAGCTGCTAAGAGAAGCGGAGCACCTGGGGACTCACCGACACATTCCTCCTGCCAA CAGGTCACCTTCAAGCCAGTGTCCTGACCCAGTGCCTTAAGGTTTTGGTGAAATTAGCCGAAAACACTTCCTGTGATTTCTTGCCCAGAGCCGCAAGATT GGGGAGAACTGTGAACACAACCAGCCCACCCCCTCATCCAGTAATCCAGTCTCCCTCAGCACTCTACCAAAGGGTTCCAGTGTGTGTTCCAAGTGCTGCC AAAGTGCCTCAGCCCAGAGACACCCCTGCCTAGCGTGCTGCTGGCTGTTGAGCTCCTCTCCCTGCTGGCGGACCACGACCAGCTGGCACCTCAGCTCTGT TCCCACTCAGAAGGCTGCCTCCTGCTGCTGCTGTACATGTACATCACATCACGGCCTGACAGAGTGGCCTTGGAGACACAATGGCTCCAGCTGGAACAAG AGGTGGTGTGGCTCCTGGCTAAGCTTGGTGTGCAGAGCCCCTTGCCCCCAGTCACTGGCTCCAACTGCCAGTGTAATGTGGAGGTGGTCAGAGCGCTCAC GGTGATGTTGCACAGACAGTGGCTGACAGTGCGGAGGGCAGGGGGACCCCCAAGGACCGACCAGCAGAGGCGGACAGTGCGCTGTCTGCGGGACACGGTG CTGCTGCTGCACGGCCTATCGCAGAAGGACAAGCTCTTCATGATGCACTGCGTGGAGGTCCTGCATCAGTTTGACCAGGTGATGCCGGGGGTCAGCATGC TCATCCGAGGGCTTCCTGATGTGACGGACTGTGAAGAGGCAGCCCTGGATGACCTCTGTGCCGCGGAAACCGATGTGGAAGACCCCGAGGTGGAGTGTGG CTGAGGCCCTGAGTGTCCAGCCACATGGTGGCACCAGCACCACTCCTTTCCTTACCACATCAACTGATTAAAGCAGTGACCAGCAGGAACTGCCCAGAGA ACTGGCTGGCCTTGTTTCCTGAGTCTGATCTGTTTGGCGGAGTGGGAGGGGTGGAGCAGGACCCGGACCCTGAGTGGCTGGGATCCTTCTTCCTGTCCCT GGCTGTTGCTGAGCCCGTCCCCATGGTAACTGATCTGCCTTGAGGAAGGAGCCCTGCCCTGCCTGTGGAATTGTCCTGAGTCATTGCTTTGGGCTGGGGC CATGGGAAGAAACCATTGTGTGGCAGGGAAGGAGGTGGCTCTTGGCCCAGGCCTAAACCAGGAAAGCCTGGGAAACTGGGACCCACAGGTGGGCATGAAA GGGCCGCAGCAGGGGCTCCCAGCAGTGTGTAAGACCGGGAGCTGGTCTGGCACCACTGCCCTGGTCCTTCCAGCTGCCTGTCACTGGTATGATGGCCCCG GTGCATTGTGCCACCAGCAGGCCACAGCTGTGGATCTTGGAAGGCCTCTGGGGTCCCCCGGGAGCAGGGGAGTGGGTGTGGGGGGGAACGGATGGTGGTG AGAGGGACAGACCAGGCAGGCTGACGAGCAGGGCGGGCCTGGCTCACGTGGGCCTGTAGGCGGGCCCACGCCAAGTTTCACTTCCCGCCACTGCTGCCAG CGAGAGCCGCGGGAGAGTGTGCAGCCGAGTCACTACTGCCTGCCTGCCTGCCTGCTACGGCTCAGCAGCAGGTACGTACCCAACCATGGGCTCGCAGGCC CTGCCCCCGGGGCCCATGCAGACCCTCATCTTTTTCGACATGGAGGCCACTGGCTTGCCCTTCTCCCAGCCCAAGGTCACGGAGCTGTGCCTGCTGGCTG TCCACAGATGTGCCCTGGAGAGCCCCCCCACCTCTCAGGGGCCACCTCCCACAGTTCCTCCACCACCGCGTGTGGTAGACAAGCTCTCCCTGTGTGTGGC TCCGGGGAAGGCCTGCAGCCCTGCAGCCAGCGAGATCACAGGTCTGAGCACAGCTGTGCTGGCAGCGCATGGGCGTCAATGTTTTGATGACAACCTGGCC AACCTGCTCCTAGCCTTCCTGCGGCGCCAGCCACAGCCCTGGTGCCTGGTGGCACACAATGGTGACCGCTACGACTTCCCCCTGCTCCAAGCAGAGCTGG CTATGCTGGGCCTCACCAGTGCTCTGGATGGTGCCTTCTGTGTGGATAGCATCACTGCGCTGAAGGCCCTGGAGCGAGCAAGCAGCCCCTCAGAACACGG CCCAAGGAAGAGCTACAGCCTAGGCAGCATCTACACTCGCCTGTATGGGCAGTCCCCTCCAGACTCGCACACGGCTGAGGGTGATGTCCTGGCCCTGCTC AGCATCTGTCAGTGGAGACCACAGGCCCTGCTGCGGTGGGTGGATGCTCACGCCAGGCCTTTCGGCACCATCAGGCCCATGTATGGGGTCACAGCCTCTG CTAGGACCAAGCCAAGACCATCTGCTGTCACAACCACTGCACACCTGGCCACAACCAGGAACACTAGTCCCAGCCTTGGAGAGAGCAGGGGTACCAAGGA TCTTCCTCCAGTGAAGGACCCTGGAGCCCTATCCAGGGAGGGGCTGCTGGCCCCACTGGGTCTGCTGGCCATCCTGACCTTGGCAGTAGCCACACTGTAT GGACTATCCCTGGCCACACCTGGGGAGTAGGCCAAGAAGGAAAATCTGACGAATAAAGACCCCCGCTGCCCCATA

refseq_TREX1.F4 (forward primer)
refseq_TREX1.R4 (reverse primer)
Single exon skipping

Frame 0

ALSDTWGERKAWRGPPRQAARGGASPRRLAPAR RRAPGTPRASGPGASPQPLPRTLTTRSARMGTSL PTTWRSLTPSRHRP*ANVRPRLGTCPVIIRSTD Y*MACQKILQGKTEKLFQLKIISN*RYFRHNTK NLKKR*K*WKKKFSLRMEKLKFCETHYIRRNPF* RNREDHIFFLSKRKPKHSVTRKRNSPKSSNHCS LNSSLKMQR*MN*GQSSRPVNEQINWLLPLFPM SVLGKTLLWL*SQKHVLHNLEKHLFLQRSLLVLT CPFPTPARRSQDTSLWWAERIVSPTV*EVTP*N KKRPRKALLTAGDRDQTLKVPF**TCS*SSL*S QGHP*AFATS*VVVLSLLLAPPCSHQGLAVPWLE CQASGPQVLMMGHFPSQP*EKHRTWHSLD*IWL PGMSAHVMETQQREAEGPSHSASFLEPCISSPL YSSSSAYTARPCRTWQLLREAEHLGTHRHIPPAN RSPSSQCPDPVP*GFGEISRKHFL*FLAQSRKI GENCEHNQPTPSSSNPVSLSTLPKGSSVCSKCC QSASAQRHPCLACCWLLSSSPCWRTTTSWHLSSV PTQKAASCCCCTCTSHHGLTEWPWRHNGSSWNK RWCGSWLSLVCRAPCPQSLAPTASVMWRWSERS R*CCTDSG*QCGGQGDPQGPTSRGGQCAVCGTRC CCCTAYRRRTSSS*CTAWRSCISLTR*CRGSAC SSEGFLM*RTVKRQPWMTSVPRKPMWKTPRWSV AEALSVQPHGGTSTTPFLTTSTD*SSDQQELPRE LAGLVS*V*SVWRSGRGGAGPGP*VAGILLPVP GCC*ARPHGN*SALRKEPCPACGIVLSHCFGLG PWEETIVWQGRRWLLAQA*TRKAWETGTHRWA*K GRSRGSQQCVRPGAGLAPLPWSFQLPVTGMMAP VHCATSRPQLWILEGLWGPPGAGEWVWGGTDGG ERDRPGRLTSRAGLAHVGL*AGPRQVSLPATAAS ESRGRVCSRVTTACLPACYGSAAGTYPTMGSQA LPPGPMQTLIFFDMEATGLPFSQPKVTELCLLA VHRCALESPPTSQGPPPTVPPPPRVVDKLSLCVA PGKACSPAASEITGLSTAVLAAHGRQCFDDNLA NLLLAFLRRQPQPWCLVAHNGDRYDFPLLQAEL AMLGLTSALDGAFCVDSITALKALERASSPSEHG PRKSYSLGSIYTRLYGQSPPDSHTAEGDVLALL SICQWRPQALLRWVDAHARPFGTIRPMYGVTAS ARTKPRPSAVTTTAHLATTRNTSPSLGESRGTKD LPPVKDPGALSREGLLAPLGLLAILTLAVATLY GLSLATPGE*AKKENLTNKDPRCPI

Frame 1

RCRILGVSGKHGGDLRARQQEAERAPGASPRPA AGHRAPPEQAGPGLLRSRCPGP*RPVRRAWGLH CRRPGGA*HPRVTGPEPMSGRGSGRVQ*S*GPQI IRWHVKKSFREKQRNCSN*R*FRIRGTSGTIQR T*RKDESNGRRSSH*EWRN*NFARLTTSDGIRS RGTEKITFSS*ARENPSTQ*QGKGILQKAPIIAV *TPV*RCRDE*IKDKAPDQ*TSK*TGCSLCFPC QS*EKPFCGYKARSMFSTIWKNIFSYKGVF*C* HVPSPPLPDGVRIQASGGQRG**APQSER*LHKT RRGPEKLC*QLETEIKHSRFHFDKPAPEAAFDP RVIPKPLPPPE**F*VSCWHPPAATRVWQYLGW NVRPQDHRFL*WVIFPLSPERSTEPGIHWTESGC PE*VLT*WRPSRGRQKGLPTLPASWSRAFPPPC TVLHRLTLPGPAGLGSC*EKRSTWGLTDTFLLP TGHLQASVLTQCLKVLVKLAENTSCDFLPRAARL GRTVNTTSPPPHPVIQSPSALYQRVPVCVPSAA KVPQPRDTPA*RAAGC*APLPAGGPRPAGTSAL FPLRRLPPAAAVHVHHITA*QSGLGDTMAPAGTR GGVAPG*AWCAEPLAPSHWLQLPV*CGGGQSAH GDVAQTVADSAEGRGTPKDRPAEADSALSAGHG AAAARPIAEGQALHDALRGGPASV*PGDAGGQHA HPRAS*CDGL*RGSPG*PLCRGNRCGRPRGGVW LRP*VSSHMVAPAPLLSLPHQLIKAVTSRNCPE NWLALFPESDLFGGVGGVEQDPDPEWLGSFFLSL AVAEPVPMVTDLP*GRSPALPVELS*VIALGWG HGKKPLCGREGGGSWPRPKPGKPGKLGPTGGHE RAAAGAPSSV*DRELVWHHCPGPSSCLSLV*WPR CIVPPAGHSCGSWKASGVPREQGSGCGGERMVV RGTDQAG*RAGRAWLTWACRRAHAKFHFPPLLP ARAAGECAAESLLPACLPATAQQQVRTQPWARRP CPRGPCRPSSFSTWRPLACPSPSPRSRSCACWL STDVPWRAPPPLRGHLPQFLHHRVW*TSSPCVW LRGRPAALQPARSQV*AQLCWQRMGVNVLMTTWP TCS*PSCGASHSPGAWWHTMVTATTSPCSKQSW LCWASPVLWMVPSVWIASLR*RPWSEQAAPQNT AQGRATA*AASTLACMGSPLQTRTRLRVMSWPCS ASVSGDHRPCCGGWMLTPGLSAPSGPCMGSQPL LGPSQDHLLSQPLHTWPQPGTLVPALERAGVPR IFLQ*RTLEPYPGRGCWPHWVCWPS*PWQ*PHCM DYPWPHLGSRPRRKI*RIKTPAAP

Frame 2

AVGYLG*AESMAGTSAPGSKRRSEPPAPRPGPP PGTGHPPSKRARGFSAAAAPDPDDPFGAHGDFT ADDLEELDTLASQALSQCPAAARDVSSDHKVHR LLDGMSKNPSGKNRETVPIKDNFELEVLQAQYKE LKEKMKVMEEEVLIKNGEIKILRDSLHQTESVL EEQRRSHFLLEQEKTQALSDKEKEFSKKLQSLQ SELQFKDAEMNELRTKLQTSERANKLAAPSVSHV SPRKNPSVVIKPEACSPQFGKTSFPTKESFSAN MSLPHPCQTESGYKPLVGREDSKPHSLRGDSIK QEEAQKSFVDSWRQRSNTQGSILINLLLKQPLIP GSSLSLCHLLSSSSESPAGTPLQPPGFGSTLAG MSGLRTTGSYDGSFSLSALREAQNLAFTGLNLV ARNECSRDGDPAEGGRRAFPLCQLPGAVHFLPLV QFFIGLHCQALQDLAAAKRSGAPGDSPTHSSCQ QVTFKPVS*PSALRFW*N*PKTLPVISCPEPQD WGEL*TQPAHPLIQ*SSLPQHSTKGFQCVFQVLP KCLSPETPLPSVLLAVELLSLLADHDQLAPQLC SHSEGCLLLLLYMYITSRPDRVALETQWLQLEQ EVVWLLAKLGVQSPLPPVTGSNCQCNVEVVRALT VMLHRQWLTVRRAGGPPRTDQQRRTVRCLRDTV LLLHGLSQKDKLFMMHCVEVLHQFDQVMPGVSM LIRGLPDVTDCEEAALDDLCAAETDVEDPEVECG *GPECPATWWHQHHSFPYHIN*LKQ*PAGTAQR TGWPCFLSLICLAEWEGWSRTRTLSGWDPSSCP WLLLSPSPW*LICLEEGALPCLWNCPESLLWAGA MGRNHCVAGKEVALGPGLNQESLGNWDPQVGMK GPQQGLPAVCKTGSWSGTTALVLPAACHWYDGP GALCHQQATAVDLGRPLGSPGSRGVGVGGNGWW* EGQTRQADEQGGPGSRGPVGGPTPSFTSRHCCQ REPRESVQPSHYCLPACLLRLSSRYVPNHGLAG PAPGAHADPHLFRHGGHWLALLPAQGHGAVPAGC PQMCPGEPPHLSGATSHSSSTTACGRQALPVCG SGEGLQPCSQRDHRSEHSCAGSAWASMF**QPG QPAPSLPAAPATALVPGGTQW*PLRLPPAPSRAG YAGPHQCSGWCLLCG*HHCAEGPGASKQPLRTR PKEELQPRQHLHSPVWAVPSRLAHG*G*CPGPA QHLSVETTGPAAVGGCSRQAFRHHQAHVWGHSLC *DQAKTICCHNHCTPGHNQEH*SQPWREQGYQG SSSSEGPWSPIQGGAAGPTGSAGHPDLGSSHTV WTIPGHTWGVGQEGKSDE*RPPLPH