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Sequences

Sequence NM_021056

GGTGCGTCCTGGTCCACCATGGCCAAACCAACAAGCAAAGATTCAGGCTTGAAGGAGAAGTTTAAGATTCTGTTGGGACTGGGAACACCGAGGCCAAATC CCAGGTCTGCAGAGGGTAAACAGACGGAGTTTATCATCACCGCGGAAATACTGAGAGAACTGAGCATGGAATGTGGCCTCAACAATCGCATCCGGATGAT AGGGCAGATTTGTGAAGTCGCAAAAACCAAGAAATTTGAAGAGCACGCAGTGGAAGCACTCTGGAAGGCGGTCGCGGATCTGTTGCAGCCGGAGCGGCCG CTGGAGGCCCGGCACGCGGTGCTGGCTCTGCTGAAGGCCATCGTGCAGGGGCAGGGCGAGCGTTTGGGGGTCCTCAGAGCCCTCTTCTTTAAGGTCATCA AGGATTACCCTTCCAACGAAGACCTTCACGAAAGGCTGGAGGTTTTCAAGGCCCTCACAGACAATGGGAGACACATCACCTACTTGGAGGAAGAGCTGGC TGACTTTGTCCTGCAGTGGATGGATGTTGGCTTGTCCTCGGAATTCCTTCTGGTGCTGGTGAACTTGGTCAAATTCAATAGCTGTTACCTCGACGAGTAC ATCGCAAGGATGGTTCAGATGATCTGTCTGCTGTGCGTCCGGACCGCGTCCTCTGTGGACATAGAGGTCTCCCTGCAGGTGCTGGACGCCGTGGTCTGCT ACAACTGCCTGCCGGCTGAGAGCCTCCCGCTGTTCATCGTTACCCTCTGTCGCACCATCAACGTCAAGGAGCTCTGCGAGCCTTGCTGGAAGCTGATGCG GAACCTCCTTGGCACCCACCTGGGCCACAGCGCCATCTACAACATGTGCCACCTCATGGAGGACAGAGCCTACATGGAGGACGCGCCCCTGCTGAGAGGA GCCGTGTTTTTTGTGGGCATGGCTCTCTGGGGAGCCCACCGGCTCTATTCTCTCAGGAACTCGCCGACATCTGTGTTGCCATCATTTTACCAGGCCATGG CATGTCCGAACGAGGTGGTGTCCTATGAGATCGTCCTGTCCATCACCAGGCTCATCAAGAAGTATAGGAAGGAGCTCCAGGTGGTGGCGTGGGACATTCT GCTGAACATCATCGAACGGCTCCTTCAGCAGCTCCAGACCTTGGACAGCCCGGAGCTCAGGACCATCGTCCATGACCTGTTGACCACGGTGGAGGAGCTG TGTGACCAGAACGAGTTCCACGGGTCTCAGGAGAGATACTTTGAACTGGTGGAGAGATGTGCGGACCAGAGGCCTGAGTCCTCCCTCCTGAACCTGATCT CCTATAGAGCGCAGTCCATCCACCCGGCCAAGGACGGCTGGATTCAGAACCTGCAGGCGCTGATGGAGAGATTCTTCAGGAGCGAGTCCCGAGGCGCCGT GCGCATCAAGGTGCTGGACGTGCTGTCCTTTGTGCTGCTCATCAACAGGCAGTTCTATGAGGAGGAGCTGATTAACTCAGTGGTCATCTCGCAGCTCTCC CACATCCCCGAGGATAAAGACCACCAGGTCCGAAAGCTGGCCACCCAGTTGCTGGTGGACCTGGCAGAGGGCTGCCACACACACCACTTCAACAGCCTGC TGGACATCATCGAGAAGGTGATGGCCCGCTCCCTCTCCCCACCCCCGGAGCTGGAAGAAAGGGATGTGGCCGCATACTCGGCCTCCTTGGAGGATGTGAA GACAGCCGTCCTGGGGCTTCTGGTCATCCTTCAGACCAAGCTGTACACCCTGCCTGCAAGCCACGCCACGCGTGTGTATGAGATGCTGGTCAGCCACATT CAGCTCCACTACAAGCACAGCTACACCCTGCCAATCGCGAGCAGCATCCGGCTGCAGGCCTTTGACTTCCTGTTGCTGCTGCGGGCCGACTCACTGCACC GCCTGGGCCTGCCCAACAAGGATGGAGTCGTGCGGTTCAGCCCCTACTGCGTCTGCGACTACATGGAGCCAGAGAGAGGCTCTGAGAAGAAGACCAGCGG CCCCCTTTCTCCTCCCACAGGGCCTCCTGGCCCGGCGCCTGCAGGCCCCGCCGTGCGGCTGGGGTCCGTGCCCTACTCCCTGCTCTTCCGCGTCCTGCTG CAGTGCTTGAAGCAGGAGTCTGACTGGAAGGTGCTGAAGCTGGTTCTGGGCAGGCTGCCTGAGTCCCTGCGCTATAAAGTGCTCATCTTTACTTCCCCTT GCAGTGTGGACCAGCTGTGCTCTGCTCTCTGCTCCATGCTTTCAGGCCCAAAGACACTGGAGCGGCTCCGAGGCGCCCCAGAAGGCTTCTCCAGAACTGA CTTGCACCTGGCCGTGGTTCCAGTGCTGACAGCATTAATCTCTTACCATAACTACCTGGACAAAACCAAACAGCGCGAGATGGTCTACTGCCTGGAGCAG GGCCTCATCCACCGCTGTGCCAGCCAGTGCGTCGTGGCCTTGTCCATCTGCAGCGTGGAGATGCCTGACATCATCATCAAGGCGCTGCCTGTTCTGGTGG TGAAGCTCACGCACATCTCAGCCACAGCCAGCATGGCCGTCCCACTGCTGGAGTTCCTGTCCACTCTGGCCAGGCTGCCGCACCTCTACAGGAACTTTGC CGCGGAGCAGTATGCCAGTGTGTTCGCCATCTCCCTGCCGTACACCAACCCCTCCAAGTTTAATCAGTACATCGTGTGTCTGGCCCATCACGTCATAGCC ATGTGGTTCATCAGGTGCCGCCTGCCCTTCCGGAAGGATTTTGTCCCTTTCATCACTAAGGGCCTGCGGTCCAATGTCCTCTTGTCTTTTGATGACACCC CCGAGAAGGACAGCTTCAGGGCCCGGAGTACTAGTCTCAACGAGAGACCCAAGAGGATACAGACGTCCCTCACCAGTGCCAGCTTGGGGTCTGCAGATGA GAACTCCGTGGCCCAGGCTGACGATAGCCTGAAAAACCTCCACCTGGAGCTCACGGAAACCTGTCTGGACATGATGGCTCGATACGTCTTCTCCAACTTC ACGGCTGTCCCGAAGAGGTCTCCTGTGGGCGAGTTCCTCCTAGCGGGTGGCAGGACCAAAACCTGGCTGGTTGGGAACAAGCTTGTCACTGTGACGACAA GCGTGGGAACCGGGACCCGGTCGTTACTAGGCCTGGACTCGGGGGAGCTGCAGTCCGGCCCGGAGTCGAGCTCCAGCCCCGGGGTGCATGTGAGACAGAC CAAGGAGGCGCCGGCCAAGCTGGAGTCCCAGGCTGGGCAGCAGGTGTCCCGTGGGGCCCGGGATCGGGTCCGTTCCATGTCGGGGGGCCATGGTCTTCGA GTTGGCGCCCTGGACGTGCCGGCCTCCCAGTTCCTGGGCAGTGCCACTTCTCCAGGACCACGGACTGCACCAGCCGCGAAACCTGAGAAGGCCTCAGCTG GCACCCGGGTTCCTGTGCAGGAGAAGACGAACCTGGCGGCCTATGTGCCCCTGCTGACCCAGGGCTGGGCGGAGATCCTGGTCCGGAGGCCCACAGGGAA CACCAGCTGGCTGATGAGCCTGGAGAACCCGCTCAGCCCTTTCTCCTCGGACATCAACAACATGCCCCTGCAGGAGCTGTCTAACGCCCTCATGGCGGCT GAGCGCTTCAAGGAGCACCGGGACACAGCCCTGTACAAGTCACTGTCGGTGCCGGCAGCCAGCACGGCCAAACCCCCTCCTCTGCCTCGCTCCAACACAG TGGCCTCTTTCTCCTCCCTGTACCAGTCCAGCTGCCAAGGACAGCTGCACAGGAGCGTTTCCTGGGCAGACTCCGCCGTGGTCATGGAGGAGGGAAGTCC GGGCGAGGTTCCTGTGCTGGTGGAGCCCCCAGGGTTGGAGGACGTTGAGGCAGCGCTAGGCATGGACAGGCGCACGGATGCCTACAGCAGGTCGTCCTCA GTCTCCAGCCAGGAGGAGAAGTCGCTCCACGCGGAGGAGCTGGTTGGCAGGGGCATCCCCATCGAGCGAGTCGTCTCCTCGGAGGGTGGCCGGCCCTCTG TGGACCTCTCCTTCCAGCCCTCGCAGCCCCTGAGCAAGTCCAGCTCCTCTCCCGAGCTGCAGACTCTGCAGGACATCCTCGGGGACCCTGGGGACAAGGC CGACGTGGGCCGGCTGAGCCCTGAGGTTAAGGCCCGGTCACAGTCAGGGACCCTGGACGGGGAAAGTGCTGCCTGGTCGGCCTCGGGCGAAGACAGTCGG GGCCAGCCCGAGGGTCCCTTGCCTTCCAGCTCCCCCCGCTCGCCCAGTGGCCTCCGGCCCCGAGGTTACACCATCTCCGACTCGGCCCCATCACGCAGGG GCAAGAGAGTAGAGAGGGACGCCTTAAAGAGCAGAGCCACAGCCTCCAATGCAGAGAAAGTGCCAGGCATCAACCCCAGTTTCGTGTTCCTGCAGCTCTA CCATTCCCCCTTCTTTGGCGACGAGTCAAACAAGCCAATCCTGCTGCCCAATGAGTCACAGTCCTTTGAGCGGTCGGTGCAGCTCCTCGACCAGATCCCA TCATACGACACCCACAAGATCGCCGTCCTGTATGTTGGAGAAGGCCAGAGCAACAGCGAGCTCGCCATCCTGTCCAATGAGCATGGCTCCTACAGGTACA CGGAGTTCCTGACGGGCCTGGGCCGGCTCATCGAGCTGAAGGACTGCCAGCCGGACAAGGTGTACCTGGGAGGCCTGGACGTGTGTGGTGAGGACGGCCA GTTCACCTACTGCTGGCACGATGACATCATGCAAGCCGTCTTCCACATCGCCACCCTGATGCCCACCAAGGACGTGGACAAGCACCGCTGCGACAAGAAG CGCCACCTGGGCAACGACTTTGTGTCCATTGTCTACAATGACTCCGGTGAGGACTTCAAGCTTGGCACCATCAAGGGCCAGTTCAACTTTGTCCACGTGA TCGTCACCCCGCTGGACTACGAGTGCAACCTGGTGTCCCTGCAGTGCAGGAAAGACATGGAGGGCCTTGTGGACACCAGCGTGGCCAAGATCGTGTCTGA CCGCAACCTGCCCTTCGTGGCCCGCCAGATGGCCCTGCACGCAAATATGGCCTCACAGGTGCATCATAGCCGCTCCAACCCCACCGATATCTACCCCTCC AAGTGGATTGCCCGGCTCCGCCACATCAAGCGGCTCCGCCAGCGGATCTGCGAGGAAGCCGCCTACTCCAACCCCAGCCTACCTCTGGTGCACCCTCCGT CCCATAGCAAAGCCCCTGCACAGACTCCAGCCGAGCCCACACCTGGCTATGAGGTGGGCCAGCGGAAGCGCCTCATCTCCTCGGTGGAGGACTTCACCGA GTTTGTGTGAGGCCGGGGCCCTCCCTCCTGCACTGGCCTTGGACGGTATTGCCTGTCAGTGAAATAAATAAAGTCCTGACCCCAGTGCACAGACATAGAG GCACAGATTGC

refseq_TSC2.F2 (forward primer)
refseq_TSC2.R2 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

GASWSTMAKPTSKDSGLKEKFKILLGLGTPRPN PRSAEGKQTEFIITAEILRELSMECGLNNRIRMI GQICEVAKTKKFEEHAVEALWKAVADLLQPERP LEARHAVLALLKAIVQGQGERLGVLRALFFKVI KDYPSNEDLHERLEVFKALTDNGRHITYLEEELA DFVLQWMDVGLSSEFLLVLVNLVKFNSCYLDEY IARMVQMICLLCVRTASSVDIEVSLQVLDAVVC YNCLPAESLPLFIVTLCRTINVKELCEPCWKLMR NLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRG AVFFVGMALWGAHRLYSLRNSPTSVLPSFYQAM ACPNEVVSYEIVLSITRLIKKYRKELQVVAWDIL LNIIERLLQQLQTLDSPELRTIVHDLLTTVEEL CDQNEFHGSQERYFELVERCADQRPESSLLNLI SYRAQSIHPAKDGWIQNLQALMERFFRSESRGAV RIKVLDVLSFVLLINRQFYEEELINSVVISQLS HIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSL LDIIEKVMARSLSPPPELEERDVAAYSASLEDVK TAVLGLLVILQTKLYTLPASHATRVYEMLVSHI QLHYKHSYTLPIASSIRLQAFDFLLLLRADSLH RLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTSG PLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLL QCLKQESDWKVLKLVLGRLPESLRYKVLIFTSP CSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTD LHLAVVPVLTALISYHNYLDKTKQREMVYCLEQ GLIHRCASQCVVALSICSVEMPDIIIKALPVLV VKLTHISATASMAVPLLEFLSTLARLPHLYRNFA AEQYASVFAISLPYTNPSKFNQYIVCLAHHVIA MWFIRCRLPFRKDFVPFITKGLRSNVLLSFDDT PEKDSFRARSTSLNERPKRIQTSLTSASLGSADE NSVAQADDSLKNLHLELTETCLDMMARYVFSNF TAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTT SVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQT KEAPAKLESQAGQQVSRGARDRVRSMSGGHGLR VGALDVPASQFLGSATSPGPRTAPAAKPEKASA GTRVPVQEKTNLAAYVPLLTQGWAEILVRRPTGN TSWLMSLENPLSPFSSDINNMPLQELSNALMAA ERFKEHRDTALYKSLSVPAASTAKPPPLPRSNT VASFSSLYQSSCQGQLHRSVSWADSAVVMEEGSP GEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSS VSSQEEKSLHAEELVGRGIPIERVVSSEGGRPS VDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKA DVGRLSPEVKARSQSGTLDGESAAWSASGEDSR GQPEGPLPSSSPRSPSGLRPRGYTISDSAPSRR GKRVERDALKSRATASNAEKVPGINPSFVFLQLY HSPFFGDESNKPILLPNESQSFERSVQLLDQIP SYDTHKIAVLYVGEGQSNSELAILSNEHGSYRY TEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQ FTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKK RHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHV IVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVSD RNLPFVARQMALHANMASQVHHSRSNPTDIYPS KWIARLRHIKRLRQRICEEAAYSNPSLPLVHPP SHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTE FV*GRGPPSCTGLGRYCLSVK*IKS*PQCTDIE AQI

Frame 1

VRPGPPWPNQQAKIQA*RRSLRFCWDWEHRGQI PGLQRVNRRSLSSPRKY*EN*AWNVASTIASG* *GRFVKSQKPRNLKSTQWKHSGRRSRICCSRSGR WRPGTRCWLC*RPSCRGRASVWGSSEPSSLRSS RITLPTKTFTKGWRFSRPSQTMGDTSPTWRKSW LTLSCSGWMLACPRNSFWCW*TWSNSIAVTSTST SQGWFR*SVCCASGPRPLWT*RSPCRCWTPWSA TTACRLRASRCSSLPSVAPSTSRSSASLAGS*C GTSLAPTWATAPSTTCATSWRTEPTWRTRPC*EE PCFLWAWLSGEPTGSILSGTRRHLCCHHFTRPW HVRTRWCPMRSSCPSPGSSRSIGRSSRWWRGTF C*TSSNGSFSSSRPWTARSSGPSSMTC*PRWRSC VTRTSSTGLRRDTLNWWRDVRTRGLSPPS*T*S PIERSPSTRPRTAGFRTCRR*WRDSSGASPEAP CASRCWTCCPLCCSSTGSSMRRS*LTQWSSRSSP TSPRIKTTRSESWPPSCWWTWQRAATHTTSTAC WTSSRR*WPAPSPHPRSWKKGMWPHTRPPWRM* RQPSWGFWSSFRPSCTPCLQATPRVCMRCWSATF SSTTSTATPCQSRAASGCRPLTSCCCCGPTHCT AWACPTRMESCGSAPTASATTWSQREALRRRPA APFLLPQGLLARRLQAPPCGWGPCPTPCSSASCC SA*SRSLTGRC*SWFWAGCLSPCAIKCSSLLPL AVWTSCALLSAPCFQAQRHWSGSEAPQKASPEL TCTWPWFQC*QH*SLTITTWTKPNSARWSTAWSR ASSTAVPASASWPCPSAAWRCLTSSSRRCLFWW *SSRTSQPQPAWPSHCWSSCPLWPGCRTSTGTL PRSSMPVCSPSPCRTPTPPSLISTSCVWPITS*P CGSSGAACPSGRILSLSSLRACGPMSSCLLMTP PRRTASGPGVLVSTRDPRGYRRPSPVPAWGLQM RTPWPRLTIA*KTSTWSSRKPVWT*WLDTSSPTS RLSRRGLLWASSS*RVAGPKPGWLGTSLSL*RQ AWEPGPGRY*AWTRGSCSPARSRAPAPGCM*DR PRRRRPSWSPRLGSRCPVGPGIGSVPCRGAMVFE LAPWTCRPPSSWAVPLLQDHGLHQPRNLRRPQL APGFLCRRRRTWRPMCPC*PRAGRRSWSGGPQG TPAG**AWRTRSALSPRTSTTCPCRSCLTPSWRL SASRSTGTQPCTSHCRCRQPARPNPLLCLAPTQ WPLSPPCTSPAAKDSCTGAFPGQTPPWSWRREV RARFLCWWSPQGWRTLRQR*AWTGARMPTAGRPQ SPARRRSRSTRRSWLAGASPSSESSPRRVAGPL WTSPSSPRSP*ASPAPLPSCRLCRTSSGTLGTR PTWAG*ALRLRPGHSQGPWTGKVLPGRPRAKTVG ASPRVPCLPAPPARPVASGPEVTPSPTRPHHAG ARE*RGTP*RAEPQPPMQRKCQASTPVSCSCSS TIPPSLATSQTSQSCCPMSHSPLSGRCSSSTRSH HTTPTRSPSCMLEKARATASSPSCPMSMAPTGT RSS*RAWAGSSS*RTASRTRCTWEAWTCVVRTA SSPTAGTMTSCKPSSTSPP*CPPRTWTSTAATRS ATWATTLCPLSTMTPVRTSSLAPSRASSTLST* SSPRWTTSATWCPCSAGKTWRALWTPAWPRSCL TATCPSWPARWPCTQIWPHRCIIAAPTPPISTPP SGLPGSATSSGSASGSARKPPTPTPAYLWCTLR PIAKPLHRLQPSPHLAMRWASGSASSPRWRTSP SLCEAGALPPALALDGIACQ*NK*SPDPSAQT*R HRL

Frame 2

CVLVHHGQTNKQRFRLEGEV*DSVGTGNTEAKS QVCRG*TDGVYHHRGNTERTEHGMWPQQSHPDD RADL*SRKNQEI*RARSGSTLEGGRGSVAAGAA AGGPARGAGSAEGHRAGAGRAFGGPQSPLL*GHQ GLPFQRRPSRKAGGFQGPHRQWETHHLLGGRAG *LCPAVDGCWLVLGIPSGAGELGQIQ*LLPRRV HRKDGSDDLSAVRPDRVLCGHRGLPAGAGRRGLL QLPAG*EPPAVHRYPLSHHQRQGALRALLEADA EPPWHPPGPQRHLQHVPPHGGQSLHGGRAPAER SRVFCGHGSLGSPPALFSQELADICVAIILPGHG MSERGGVL*DRPVHHQAHQEV*EGAPGGGVGHS AEHHRTAPSAAPDLGQPGAQDHRP*PVDHGGGA V*PERVPRVSGEIL*TGGEMCGPEA*VLPPEPDL L*SAVHPPGQGRLDSEPAGADGEILQERVPRRR AHQGAGRAVLCAAHQQAVL*GGAD*LSGHLAAL PHPRG*RPPGPKAGHPVAGGPGRGLPHTPLQQPA GHHREGDGPLPLPTPGAGRKGCGRILGLLGGCE DSRPGASGHPSDQAVHPACKPRHACV*DAGQPH SAPLQAQLHPANREQHPAAGL*LPVAAAGRLTAP PGPAQQGWSRAVQPLLRLRLHGARERL*EEDQR PPFSSHRASWPGACRPRRAAGVRALLPALPRPA AVLEAGV*LEGAEAGSGQAA*VPAL*SAHLYFPL QCGPAVLCSLLHAFRPKDTGAAPRRPRRLLQN* LAPGRGSSADSINLLP*LPGQNQTARDGLLPGA GPHPPLCQPVRRGLVHLQRGDA*HHHQGAACSGG EAHAHLSHSQHGRPTAGVPVHSGQAAAPLQELC RGAVCQCVRHLPAVHQPLQV*SVHRVSGPSRHS HVVHQVPPALPEGFCPFHH*GPAVQCPLVF**HP REGQLQGPEY*SQRETQEDTDVPHQCQLGVCR* ELRGPG*R*PEKPPPGAHGNLSGHDGSIRLLQL HGCPEEVSCGRVPPSGWQDQNLAGWEQACHCDDK RGNRDPVVTRPGLGGAAVRPGVELQPRGACETD QGGAGQAGVPGWAAGVPWGPGSGPFHVGGPWSS SWRPGRAGLPVPGQCHFSRTTDCTSRET*EGLSW HPGSCAGEDEPGGLCAPADPGLGGDPGPEAHRE HQLADEPGEPAQPFLLGHQQHAPAGAV*RPHGG *ALQGAPGHSPVQVTVGAGSQHGQTPSSASLQHS GLFLLPVPVQLPRTAAQERFLGRLRRGHGGGKS GRGSCAGGAPRVGGR*GSARHGQAHGCLQQVVL SLQPGGEVAPRGGAGWQGHPHRASRLLGGWPALC GPLLPALAAPEQVQLLSRAADSAGHPRGPWGQG RRGPAEP*G*GPVTVRDPGRGKCCLVGLGRRQS GPARGSLAFQLPPLAQWPPAPRLHHLRLGPITQG QESREGRLKEQSHSLQCRESARHQPQFRVPAAL PFPLLWRRVKQANPAAQ*VTVL*AVGAAPRPDP IIRHPQDRRPVCWRRPEQQRARHPVQ*AWLLQVH GVPDGPGPAHRAEGLPAGQGVPGRPGRVW*GRP VHLLLAR*HHASRLPHRHPDAHQGRGQAPLRQE APPGQRLCVHCLQ*LR*GLQAWHHQGPVQLCPRD RHPAGLRVQPGVPAVQERHGGPCGHQRGQDRV* PQPALRGPPDGPARKYGLTGAS*PLQPHRYLPL QVDCPAPPHQAAPPADLRGSRLLQPQPTSGAPSV P*QSPCTDSSRAHTWL*GGPAEAPHLLGGGLHR VCVRPGPSLLHWPWTVLPVSEINKVLTPVHRHR GTDC

Sequence NM_000548

GGTGCGTCCTGGTCCACCATGGCCAAACCAACAAGCAAAGATTCAGGCTTGAAGGAGAAGTTTAAGATTCTGTTGGGACTGGGAACACCGAGGCCAAATC CCAGGTCTGCAGAGGGTAAACAGACGGAGTTTATCATCACCGCGGAAATACTGAGAGAACTGAGCATGGAATGTGGCCTCAACAATCGCATCCGGATGAT AGGGCAGATTTGTGAAGTCGCAAAAACCAAGAAATTTGAAGAGCACGCAGTGGAAGCACTCTGGAAGGCGGTCGCGGATCTGTTGCAGCCGGAGCGGCCG CTGGAGGCCCGGCACGCGGTGCTGGCTCTGCTGAAGGCCATCGTGCAGGGGCAGGGCGAGCGTTTGGGGGTCCTCAGAGCCCTCTTCTTTAAGGTCATCA AGGATTACCCTTCCAACGAAGACCTTCACGAAAGGCTGGAGGTTTTCAAGGCCCTCACAGACAATGGGAGACACATCACCTACTTGGAGGAAGAGCTGGC TGACTTTGTCCTGCAGTGGATGGATGTTGGCTTGTCCTCGGAATTCCTTCTGGTGCTGGTGAACTTGGTCAAATTCAATAGCTGTTACCTCGACGAGTAC ATCGCAAGGATGGTTCAGATGATCTGTCTGCTGTGCGTCCGGACCGCGTCCTCTGTGGACATAGAGGTCTCCCTGCAGGTGCTGGACGCCGTGGTCTGCT ACAACTGCCTGCCGGCTGAGAGCCTCCCGCTGTTCATCGTTACCCTCTGTCGCACCATCAACGTCAAGGAGCTCTGCGAGCCTTGCTGGAAGCTGATGCG GAACCTCCTTGGCACCCACCTGGGCCACAGCGCCATCTACAACATGTGCCACCTCATGGAGGACAGAGCCTACATGGAGGACGCGCCCCTGCTGAGAGGA GCCGTGTTTTTTGTGGGCATGGCTCTCTGGGGAGCCCACCGGCTCTATTCTCTCAGGAACTCGCCGACATCTGTGTTGCCATCATTTTACCAGGCCATGG CATGTCCGAACGAGGTGGTGTCCTATGAGATCGTCCTGTCCATCACCAGGCTCATCAAGAAGTATAGGAAGGAGCTCCAGGTGGTGGCGTGGGACATTCT GCTGAACATCATCGAACGGCTCCTTCAGCAGCTCCAGACCTTGGACAGCCCGGAGCTCAGGACCATCGTCCATGACCTGTTGACCACGGTGGAGGAGCTG TGTGACCAGAACGAGTTCCACGGGTCTCAGGAGAGATACTTTGAACTGGTGGAGAGATGTGCGGACCAGAGGCCTGAGTCCTCCCTCCTGAACCTGATCT CCTATAGAGCGCAGTCCATCCACCCGGCCAAGGACGGCTGGATTCAGAACCTGCAGGCGCTGATGGAGAGATTCTTCAGGAGCGAGTCCCGAGGCGCCGT GCGCATCAAGGTGCTGGACGTGCTGTCCTTTGTGCTGCTCATCAACAGGCAGTTCTATGAGGAGGAGCTGATTAACTCAGTGGTCATCTCGCAGCTCTCC CACATCCCCGAGGATAAAGACCACCAGGTCCGAAAGCTGGCCACCCAGTTGCTGGTGGACCTGGCAGAGGGCTGCCACACACACCACTTCAACAGCCTGC TGGACATCATCGAGAAGGTGATGGCCCGCTCCCTCTCCCCACCCCCGGAGCTGGAAGAAAGGGATGTGGCCGCATACTCGGCCTCCTTGGAGGATGTGAA GACAGCCGTCCTGGGGCTTCTGGTCATCCTTCAGACCAAGCTGTACACCCTGCCTGCAAGCCACGCCACGCGTGTGTATGAGATGCTGGTCAGCCACATT CAGCTCCACTACAAGCACAGCTACACCCTGCCAATCGCGAGCAGCATCCGGCTGCAGGCCTTTGACTTCCTGTTGCTGCTGCGGGCCGACTCACTGCACC GCCTGGGCCTGCCCAACAAGGATGGAGTCGTGCGGTTCAGCCCCTACTGCGTCTGCGACTACATGGAGCCAGAGAGAGGCTCTGAGAAGAAGACCAGCGG CCCCCTTTCTCCTCCCACAGGGCCTCCTGGCCCGGCGCCTGCAGGCCCCGCCGTGCGGCTGGGGTCCGTGCCCTACTCCCTGCTCTTCCGCGTCCTGCTG CAGTGCTTGAAGCAGGAGTCTGACTGGAAGGTGCTGAAGCTGGTTCTGGGCAGGCTGCCTGAGTCCCTGCGCTATAAAGTGCTCATCTTTACTTCCCCTT GCAGTGTGGACCAGCTGTGCTCTGCTCTCTGCTCCATGCTTTCAGGCCCAAAGACACTGGAGCGGCTCCGAGGCGCCCCAGAAGGCTTCTCCAGAACTGA CTTGCACCTGGCCGTGGTTCCAGTGCTGACAGCATTAATCTCTTACCATAACTACCTGGACAAAACCAAACAGCGCGAGATGGTCTACTGCCTGGAGCAG GGCCTCATCCACCGCTGTGCCAGCCAGTGCGTCGTGGCCTTGTCCATCTGCAGCGTGGAGATGCCTGACATCATCATCAAGGCGCTGCCTGTTCTGGTGG TGAAGCTCACGCACATCTCAGCCACAGCCAGCATGGCCGTCCCACTGCTGGAGTTCCTGTCCACTCTGGCCAGGCTGCCGCACCTCTACAGGAACTTTGC CGCGGAGCAGTATGCCAGTGTGTTCGCCATCTCCCTGCCGTACACCAACCCCTCCAAGTTTAATCAGTACATCGTGTGTCTGGCCCATCACGTCATAGCC ATGTGGTTCATCAGGTGCCGCCTGCCCTTCCGGAAGGATTTTGTCCCTTTCATCACTAAGGGCCTGCGGTCCAATGTCCTCTTGTCTTTTGATGACACCC CCGAGAAGGACAGCTTCAGGGCCCGGAGTACTAGTCTCAACGAGAGACCCAAGAGTCTGAGGATAGCCAGACCCCCCAAACAAGGCTTGAATAACTCTCC ACCCGTGAAAGAATTCAAGGAGAGCTCTGCAGCCGAGGCCTTCCGGTGCCGCAGCATCAGTGTGTCTGAACATGTGGTCCGCAGCAGGATACAGACGTCC CTCACCAGTGCCAGCTTGGGGTCTGCAGATGAGAACTCCGTGGCCCAGGCTGACGATAGCCTGAAAAACCTCCACCTGGAGCTCACGGAAACCTGTCTGG ACATGATGGCTCGATACGTCTTCTCCAACTTCACGGCTGTCCCGAAGAGGTCTCCTGTGGGCGAGTTCCTCCTAGCGGGTGGCAGGACCAAAACCTGGCT GGTTGGGAACAAGCTTGTCACTGTGACGACAAGCGTGGGAACCGGGACCCGGTCGTTACTAGGCCTGGACTCGGGGGAGCTGCAGTCCGGCCCGGAGTCG AGCTCCAGCCCCGGGGTGCATGTGAGACAGACCAAGGAGGCGCCGGCCAAGCTGGAGTCCCAGGCTGGGCAGCAGGTGTCCCGTGGGGCCCGGGATCGGG TCCGTTCCATGTCGGGGGGCCATGGTCTTCGAGTTGGCGCCCTGGACGTGCCGGCCTCCCAGTTCCTGGGCAGTGCCACTTCTCCAGGACCACGGACTGC ACCAGCCGCGAAACCTGAGAAGGCCTCAGCTGGCACCCGGGTTCCTGTGCAGGAGAAGACGAACCTGGCGGCCTATGTGCCCCTGCTGACCCAGGGCTGG GCGGAGATCCTGGTCCGGAGGCCCACAGGGAACACCAGCTGGCTGATGAGCCTGGAGAACCCGCTCAGCCCTTTCTCCTCGGACATCAACAACATGCCCC TGCAGGAGCTGTCTAACGCCCTCATGGCGGCTGAGCGCTTCAAGGAGCACCGGGACACAGCCCTGTACAAGTCACTGTCGGTGCCGGCAGCCAGCACGGC CAAACCCCCTCCTCTGCCTCGCTCCAACACAGTGGCCTCTTTCTCCTCCCTGTACCAGTCCAGCTGCCAAGGACAGCTGCACAGGAGCGTTTCCTGGGCA GACTCCGCCGTGGTCATGGAGGAGGGAAGTCCGGGCGAGGTTCCTGTGCTGGTGGAGCCCCCAGGGTTGGAGGACGTTGAGGCAGCGCTAGGCATGGACA GGCGCACGGATGCCTACAGCAGGTCGTCCTCAGTCTCCAGCCAGGAGGAGAAGTCGCTCCACGCGGAGGAGCTGGTTGGCAGGGGCATCCCCATCGAGCG AGTCGTCTCCTCGGAGGGTGGCCGGCCCTCTGTGGACCTCTCCTTCCAGCCCTCGCAGCCCCTGAGCAAGTCCAGCTCCTCTCCCGAGCTGCAGACTCTG CAGGACATCCTCGGGGACCCTGGGGACAAGGCCGACGTGGGCCGGCTGAGCCCTGAGGTTAAGGCCCGGTCACAGTCAGGGACCCTGGACGGGGAAAGTG CTGCCTGGTCGGCCTCGGGCGAAGACAGTCGGGGCCAGCCCGAGGGTCCCTTGCCTTCCAGCTCCCCCCGCTCGCCCAGTGGCCTCCGGCCCCGAGGTTA CACCATCTCCGACTCGGCCCCATCACGCAGGGGCAAGAGAGTAGAGAGGGACGCCTTAAAGAGCAGAGCCACAGCCTCCAATGCAGAGAAAGTGCCAGGC ATCAACCCCAGTTTCGTGTTCCTGCAGCTCTACCATTCCCCCTTCTTTGGCGACGAGTCAAACAAGCCAATCCTGCTGCCCAATGAGTCACAGTCCTTTG AGCGGTCGGTGCAGCTCCTCGACCAGATCCCATCATACGACACCCACAAGATCGCCGTCCTGTATGTTGGAGAAGGCCAGAGCAACAGCGAGCTCGCCAT CCTGTCCAATGAGCATGGCTCCTACAGGTACACGGAGTTCCTGACGGGCCTGGGCCGGCTCATCGAGCTGAAGGACTGCCAGCCGGACAAGGTGTACCTG GGAGGCCTGGACGTGTGTGGTGAGGACGGCCAGTTCACCTACTGCTGGCACGATGACATCATGCAAGCCGTCTTCCACATCGCCACCCTGATGCCCACCA AGGACGTGGACAAGCACCGCTGCGACAAGAAGCGCCACCTGGGCAACGACTTTGTGTCCATTGTCTACAATGACTCCGGTGAGGACTTCAAGCTTGGCAC CATCAAGGGCCAGTTCAACTTTGTCCACGTGATCGTCACCCCGCTGGACTACGAGTGCAACCTGGTGTCCCTGCAGTGCAGGAAAGACATGGAGGGCCTT GTGGACACCAGCGTGGCCAAGATCGTGTCTGACCGCAACCTGCCCTTCGTGGCCCGCCAGATGGCCCTGCACGCAAATATGGCCTCACAGGTGCATCATA GCCGCTCCAACCCCACCGATATCTACCCCTCCAAGTGGATTGCCCGGCTCCGCCACATCAAGCGGCTCCGCCAGCGGATCTGCGAGGAAGCCGCCTACTC CAACCCCAGCCTACCTCTGGTGCACCCTCCGTCCCATAGCAAAGCCCCTGCACAGACTCCAGCCGAGCCCACACCTGGCTATGAGGTGGGCCAGCGGAAG CGCCTCATCTCCTCGGTGGAGGACTTCACCGAGTTTGTGTGAGGCCGGGGCCCTCCCTCCTGCACTGGCCTTGGACGGTATTGCCTGTCAGTGAAATAAA TAAAGTCCTGACCCCAGTGCACAGACATAGAGGCACAGATTGC

refseq_TSC2.F2 (forward primer)
refseq_TSC2.R2 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

GASWSTMAKPTSKDSGLKEKFKILLGLGTPRPN PRSAEGKQTEFIITAEILRELSMECGLNNRIRMI GQICEVAKTKKFEEHAVEALWKAVADLLQPERP LEARHAVLALLKAIVQGQGERLGVLRALFFKVI KDYPSNEDLHERLEVFKALTDNGRHITYLEEELA DFVLQWMDVGLSSEFLLVLVNLVKFNSCYLDEY IARMVQMICLLCVRTASSVDIEVSLQVLDAVVC YNCLPAESLPLFIVTLCRTINVKELCEPCWKLMR NLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRG AVFFVGMALWGAHRLYSLRNSPTSVLPSFYQAM ACPNEVVSYEIVLSITRLIKKYRKELQVVAWDIL LNIIERLLQQLQTLDSPELRTIVHDLLTTVEEL CDQNEFHGSQERYFELVERCADQRPESSLLNLI SYRAQSIHPAKDGWIQNLQALMERFFRSESRGAV RIKVLDVLSFVLLINRQFYEEELINSVVISQLS HIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSL LDIIEKVMARSLSPPPELEERDVAAYSASLEDVK TAVLGLLVILQTKLYTLPASHATRVYEMLVSHI QLHYKHSYTLPIASSIRLQAFDFLLLLRADSLH RLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTSG PLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLL QCLKQESDWKVLKLVLGRLPESLRYKVLIFTSP CSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTD LHLAVVPVLTALISYHNYLDKTKQREMVYCLEQ GLIHRCASQCVVALSICSVEMPDIIIKALPVLV VKLTHISATASMAVPLLEFLSTLARLPHLYRNFA AEQYASVFAISLPYTNPSKFNQYIVCLAHHVIA MWFIRCRLPFRKDFVPFITKGLRSNVLLSFDDT PEKDSFRARSTSLNERPKSLRIARPPKQGLNNSP PVKEFKESSAAEAFRCRSISVSEHVVRSRIQTS LTSASLGSADENSVAQADDSLKNLHLELTETCL DMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWL VGNKLVTVTTSVGTGTRSLLGLDSGELQSGPES SSSPGVHVRQTKEAPAKLESQAGQQVSRGARDR VRSMSGGHGLRVGALDVPASQFLGSATSPGPRTA PAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGW AEILVRRPTGNTSWLMSLENPLSPFSSDINNMP LQELSNALMAAERFKEHRDTALYKSLSVPAASTA KPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWA DSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMD RRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIER VVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTL QDILGDPGDKADVGRLSPEVKARSQSGTLDGES AAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGY TISDSAPSRRGKRVERDALKSRATASNAEKVPG INPSFVFLQLYHSPFFGDESNKPILLPNESQSF ERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAI LSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYL GGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPT KDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGT IKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGL VDTSVAKIVSDRNLPFVARQMALHANMASQVHH SRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYS NPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRK RLISSVEDFTEFV*GRGPPSCTGLGRYCLSVK* IKS*PQCTDIEAQI

Frame 1

VRPGPPWPNQQAKIQA*RRSLRFCWDWEHRGQI PGLQRVNRRSLSSPRKY*EN*AWNVASTIASG* *GRFVKSQKPRNLKSTQWKHSGRRSRICCSRSGR WRPGTRCWLC*RPSCRGRASVWGSSEPSSLRSS RITLPTKTFTKGWRFSRPSQTMGDTSPTWRKSW LTLSCSGWMLACPRNSFWCW*TWSNSIAVTSTST SQGWFR*SVCCASGPRPLWT*RSPCRCWTPWSA TTACRLRASRCSSLPSVAPSTSRSSASLAGS*C GTSLAPTWATAPSTTCATSWRTEPTWRTRPC*EE PCFLWAWLSGEPTGSILSGTRRHLCCHHFTRPW HVRTRWCPMRSSCPSPGSSRSIGRSSRWWRGTF C*TSSNGSFSSSRPWTARSSGPSSMTC*PRWRSC VTRTSSTGLRRDTLNWWRDVRTRGLSPPS*T*S PIERSPSTRPRTAGFRTCRR*WRDSSGASPEAP CASRCWTCCPLCCSSTGSSMRRS*LTQWSSRSSP TSPRIKTTRSESWPPSCWWTWQRAATHTTSTAC WTSSRR*WPAPSPHPRSWKKGMWPHTRPPWRM* RQPSWGFWSSFRPSCTPCLQATPRVCMRCWSATF SSTTSTATPCQSRAASGCRPLTSCCCCGPTHCT AWACPTRMESCGSAPTASATTWSQREALRRRPA APFLLPQGLLARRLQAPPCGWGPCPTPCSSASCC SA*SRSLTGRC*SWFWAGCLSPCAIKCSSLLPL AVWTSCALLSAPCFQAQRHWSGSEAPQKASPEL TCTWPWFQC*QH*SLTITTWTKPNSARWSTAWSR ASSTAVPASASWPCPSAAWRCLTSSSRRCLFWW *SSRTSQPQPAWPSHCWSSCPLWPGCRTSTGTL PRSSMPVCSPSPCRTPTPPSLISTSCVWPITS*P CGSSGAACPSGRILSLSSLRACGPMSSCLLMTP PRRTASGPGVLVSTRDPRV*G*PDPPNKA*ITL HP*KNSRRALQPRPSGAAASVCLNMWSAAGYRRP SPVPAWGLQMRTPWPRLTIA*KTSTWSSRKPVW T*WLDTSSPTSRLSRRGLLWASSS*RVAGPKPG WLGTSLSL*RQAWEPGPGRY*AWTRGSCSPARSR APAPGCM*DRPRRRRPSWSPRLGSRCPVGPGIG SVPCRGAMVFELAPWTCRPPSSWAVPLLQDHGL HQPRNLRRPQLAPGFLCRRRRTWRPMCPC*PRAG RRSWSGGPQGTPAG**AWRTRSALSPRTSTTCP CRSCLTPSWRLSASRSTGTQPCTSHCRCRQPAR PNPLLCLAPTQWPLSPPCTSPAAKDSCTGAFPGQ TPPWSWRREVRARFLCWWSPQGWRTLRQR*AWT GARMPTAGRPQSPARRRSRSTRRSWLAGASPSS ESSPRRVAGPLWTSPSSPRSP*ASPAPLPSCRLC RTSSGTLGTRPTWAG*ALRLRPGHSQGPWTGKV LPGRPRAKTVGASPRVPCLPAPPARPVASGPEV TPSPTRPHHAGARE*RGTP*RAEPQPPMQRKCQA STPVSCSCSSTIPPSLATSQTSQSCCPMSHSPL SGRCSSSTRSHHTTPTRSPSCMLEKARATASSP SCPMSMAPTGTRSS*RAWAGSSS*RTASRTRCTW EAWTCVVRTASSPTAGTMTSCKPSSTSPP*CPP RTWTSTAATRSATWATTLCPLSTMTPVRTSSLA PSRASSTLST*SSPRWTTSATWCPCSAGKTWRAL WTPAWPRSCLTATCPSWPARWPCTQIWPHRCII AAPTPPISTPPSGLPGSATSSGSASGSARKPPT PTPAYLWCTLRPIAKPLHRLQPSPHLAMRWASGS ASSPRWRTSPSLCEAGALPPALALDGIACQ*NK *SPDPSAQT*RHRL

Frame 2

CVLVHHGQTNKQRFRLEGEV*DSVGTGNTEAKS QVCRG*TDGVYHHRGNTERTEHGMWPQQSHPDD RADL*SRKNQEI*RARSGSTLEGGRGSVAAGAA AGGPARGAGSAEGHRAGAGRAFGGPQSPLL*GHQ GLPFQRRPSRKAGGFQGPHRQWETHHLLGGRAG *LCPAVDGCWLVLGIPSGAGELGQIQ*LLPRRV HRKDGSDDLSAVRPDRVLCGHRGLPAGAGRRGLL QLPAG*EPPAVHRYPLSHHQRQGALRALLEADA EPPWHPPGPQRHLQHVPPHGGQSLHGGRAPAER SRVFCGHGSLGSPPALFSQELADICVAIILPGHG MSERGGVL*DRPVHHQAHQEV*EGAPGGGVGHS AEHHRTAPSAAPDLGQPGAQDHRP*PVDHGGGA V*PERVPRVSGEIL*TGGEMCGPEA*VLPPEPDL L*SAVHPPGQGRLDSEPAGADGEILQERVPRRR AHQGAGRAVLCAAHQQAVL*GGAD*LSGHLAAL PHPRG*RPPGPKAGHPVAGGPGRGLPHTPLQQPA GHHREGDGPLPLPTPGAGRKGCGRILGLLGGCE DSRPGASGHPSDQAVHPACKPRHACV*DAGQPH SAPLQAQLHPANREQHPAAGL*LPVAAAGRLTAP PGPAQQGWSRAVQPLLRLRLHGARERL*EEDQR PPFSSHRASWPGACRPRRAAGVRALLPALPRPA AVLEAGV*LEGAEAGSGQAA*VPAL*SAHLYFPL QCGPAVLCSLLHAFRPKDTGAAPRRPRRLLQN* LAPGRGSSADSINLLP*LPGQNQTARDGLLPGA GPHPPLCQPVRRGLVHLQRGDA*HHHQGAACSGG EAHAHLSHSQHGRPTAGVPVHSGQAAAPLQELC RGAVCQCVRHLPAVHQPLQV*SVHRVSGPSRHS HVVHQVPPALPEGFCPFHH*GPAVQCPLVF**HP REGQLQGPEY*SQRETQESEDSQTPQTRLE*LS TRERIQGELCSRGLPVPQHQCV*TCGPQQDTDV PHQCQLGVCR*ELRGPG*R*PEKPPPGAHGNLSG HDGSIRLLQLHGCPEEVSCGRVPPSGWQDQNLA GWEQACHCDDKRGNRDPVVTRPGLGGAAVRPGV ELQPRGACETDQGGAGQAGVPGWAAGVPWGPGSG PFHVGGPWSSSWRPGRAGLPVPGQCHFSRTTDC TSRET*EGLSWHPGSCAGEDEPGGLCAPADPGL GGDPGPEAHREHQLADEPGEPAQPFLLGHQQHAP AGAV*RPHGG*ALQGAPGHSPVQVTVGAGSQHG QTPSSASLQHSGLFLLPVPVQLPRTAAQERFLG RLRRGHGGGKSGRGSCAGGAPRVGGR*GSARHGQ AHGCLQQVVLSLQPGGEVAPRGGAGWQGHPHRA SRLLGGWPALCGPLLPALAAPEQVQLLSRAADS AGHPRGPWGQGRRGPAEP*G*GPVTVRDPGRGKC CLVGLGRRQSGPARGSLAFQLPPLAQWPPAPRL HHLRLGPITQGQESREGRLKEQSHSLQCRESAR HQPQFRVPAALPFPLLWRRVKQANPAAQ*VTVL* AVGAAPRPDPIIRHPQDRRPVCWRRPEQQRARH PVQ*AWLLQVHGVPDGPGPAHRAEGLPAGQGVP GRPGRVW*GRPVHLLLAR*HHASRLPHRHPDAHQ GRGQAPLRQEAPPGQRLCVHCLQ*LR*GLQAWH HQGPVQLCPRDRHPAGLRVQPGVPAVQERHGGP CGHQRGQDRV*PQPALRGPPDGPARKYGLTGAS* PLQPHRYLPLQVDCPAPPHQAAPPADLRGSRLL QPQPTSGAPSVP*QSPCTDSSRAHTWL*GGPAE APHLLGGGLHRVCVRPGPSLLHWPWTVLPVSEIN KVLTPVHRHRGTDC