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Sequences

Sequence NM_014381

AACAACTGGTGCGCATGCGCACTGGTGTCTCGCGGCCTGGCGCGCCCCCTCCGAAGCGCATGCTCGTGGGCACGCACGAGCCTCAAGATCCAAGGTGCGC GCGTCGGCGTCCGAGGCGGTTGGTGTCGGAGAATTTGTTAAGCGGGACTCCAGGCAATTATTTCCAGTCAGAGAAGGAAACCAGTGCCTGGCATTCTCAC CATCTTTCTACCTACCATGATCAAGTGCTTGTCAGTTGAAGTACAAGCCAAATTGCGTTCTGGTTTGGCCATAAGCTCCTTGGGCCAATGTGTTGAGGAA CTTGCCCTCAACAGTATTGATGCTGAAGCAAAATGTGTGGCTGTCAGGGTGAATATGGAAACCTTCCAAGTTCAAGTGATAGACAATGGATTTGGGATGG GGAGTGATGATGTAGAGAAAGTGGGAAATCGTTATTTCACCAGTAAATGCCACTCGGTACAGGACTTGGAGAATCCAAGGTTTTATGGTTTCCGAGGAGA GGCCTTGGCAAATATTGCTGACATGGCCAGTGCTGTGGAAATTTCGTCCAAGAAAAACAGGACAATGAAAACTTTTGTGAAACTGTTTCAGAGTGGAAAA GCCCTGAAAGCTTGTGAAGCTGATGTGACTAGAGCAAGCGCTGGGACTACTGTAACAGTGTATAACCTATTTTACCAGCTTCCTGTAAGGAGGAAATGCA TGGACCCTAGACTGGAGTTTGAGAAGGTTAGGCAGAGAATAGAAGCTCTCTCACTCATGCACCCTTCCATTTCTTTCTCTTTGAGAAATGATGTTTCTGG TTCCATGGTTCTTCAGCTCCCTAAAACCAAAGACGTATGTTCCCGATTTTGTCAAATTTATGGATTGGGAAAGTCCCAAAAGCTAAGAGAAATAAGTTTT AAATATAAAGAGTTTGAGCTTAGTGGCTATATCAGCTCTGAAGCACATTACAACAAGAATATGCAGTTTTTGTTTGTGAACAAAAGACTAGTTTTAAGGA CAAAGCTACATAAACTCATTGACTTTTTATTAAGGAAAGAAAGTATTATATGCAAGCCAAAGAATGGTCCCACCAGTAGGCAAATGAATTCAAGTCTTCG GCACCGGTCTACCCCAGAACTCTATGGCATATATGTAATTAATGTGCAGTGCCAATTCTGTGAGTATGATGTGTGCATGGAGCCAGCCAAAACTCTGATT GAATTTCAGAACTGGGACACTCTCTTGTTTTGCATTCAGGAAGGAGTGAAAATGTTTTTAAAGCAAGAAAAATTATTTGTGGAATTATCAGGTGAGGATA TTAAGGAATTTAGTGAAGATAATGGTTTTAGTTTATTTGATGCTACTCTTCAGAAGCGTGTGACTTCCGATGAGAGGAGCAATTTCCAGGAAGCATGTAA TAATATTTTAGATTCCTATGAGATGTTTAATTTGCAGTCAAAAGCTGTGAAAAGAAAAACTACTGCAGAAAACGTAAACACACAGAGTTCTAGGGATTCA GAAGCTACCAGAAAAAATACAAATGATGCATTTTTGTACATTTATGAATCAGGTGGTCCAGGCCATAGCAAAATGACAGAGCCATCTTTACAAAACAAAG ACAGCTCTTGCTCAGAATCAAAGATGTTAGAACAAGAGACAATTGTAGCATCAGAAGCTGGAGAAAATGAGAAACATAAAAAATCTTTCCTGGAACATAG CTCTTTAGAAAATCCGTGTGGAACCAGTTTAGAAATGTTTTTAAGCCCTTTTCAGACACCATGTCACTTTGAGGAGAGTGGGCAGGATCTAGAAATATGG AAAGAAAGTACTACTGTTAATGGCATGGCTGCCAACATCTTGAAAAATAATAGAATTCAGAATCAACCAAAGAGATTTAAAGATGCTACTGAAGTGGGAT GCCAGCCTCTGCCTTTTGCAACAACATTATGGGGAGTACATAGTGCTCAGACAGAGAAAGAGAAAAAAAAAGAATCTAGCAATTGTGGAAGAAGAAATGT TTTTAGTTATGGGCGAGTTAAATTATGTTCCACTGGCTTTATAACTCATGTAGTACAAAATGAAAAAACTAAATCAACTGAAACAGAACATTCATTTAAA AATTATGTTAGACCTGGTCCCACACGTGCCCAAGAAACATTTGGAAATAGAACACGTCATTCAGTTGAAACTCCAGACATCAAAGATTTAGCCAGCACTT TAAGTAAAGAATCTGGTCAATTGCCCAACAAAAAAAATTGCAGAACGAATATAAGTTATGGGCTAGAGAATGAACCTACAGCAACTTATACAATGTTTTC TGCTTTTCAGGAAGGTAGCAAAAAATCACAAACAGATTGCATATTATCTGATACATCCCCCTCTTTCCCCTGGTATAGACACGTTTCCAATGATAGTAGG AAAACAGATAAATTAATTGGTTTCTCCAAACCAATCGTCCGTAAGAAGCTAAGCTTGAGTTCACAGCTAGGATCTTTAGAGAAGTTTAAGAGGCAATATG GGAAGGTTGAAAATCCTCTGGATACAGAAGTAGAGGAAAGTAATGGAGTCACTACCAATCTCAGTCTTCAAGTTGAACCTGACATTCTGCTGAAGGACAA GAACCGCTTAGAGAACTCTGATGTTTGTAAAATCACTACTATGGAGCATAGTGATTCAGATAGTAGTTGTCAACCAGCAAGCCACATCCTTAACTCAGAG AAGTTTCCATTCTCCAAGGATGAAGATTGTTTAGAACAACAGATGCCTAGTTTGAGAGAAAGTCCTATGACCCTGAAGGAGTTATCTCTCTTTAATAGAA AACCTTTGGACCTTGAGAAGTCATCTGAATCACTAGCCTCTAAATTATCCAGACTGAAGGGTTCCGAAAGAGAAACTCAAACAATGGGGATGATGAGTCG TTTTAATGAACTTCCAAATTCAGATTCCAGTAGGAAAGACAGCAAGTTGTGCAGTGTGTTAACACAAGATTTTTGTATGTTATTTAACAACAAGCATGAA AAAACAGAGAATGGTGTCATCCCAACATCAGATTCTGCCACACAGGATAATTCCTTTAATAAAAATAGTAAAACACATTCTAACAGCAATACAACAGAGA ACTGTGTGATATCAGAAACTCCTTTGGTATTGCCCTATAATAATTCTAAAGTTACCGGTAAAGATTCAGATGTTCTTATCAGAGCCTCAGAACAACAGAT AGGAAGTCTTGACTCTCCCAGTGGAATGTTAATGAATCCGGTAGAAGATGCCACAGGTGACCAAAATGGAATTTGTTTTCAGAGTGAGGAATCTAAAGCA AGAGCTTGTTCTGAAACTGAAGAGTCAAACACGTGTTGTTCAGATTGGCAGCGGCATTTCGATGTAGCCCTGGGAAGAATGGTTTATGTCAACAAAATGA CTGGACTCAGCACATTCATTGCCCCAACTGAGGACATTCAGGCTGCTTGTACTAAAGACCTGACAACTGTGGCTGTGGATGTTGTACTTGAGAATGGGTC TCAGTACAGGTGTCAACCTTTTAGAAGCGACCTTGTTCTTCCTTTCCTTCCGAGAGCTCGAGCAGAGAGGACTGTGATGAGACAGGATAACAGAGATACT GTGGATGATACTGTTAGTAGCGAATCGCTTCAGTCTTTGTTCTCAGAATGGGACAATCCAGTATTTGCCCGTTATCCAGAGGTTGCTGTTGATGTAAGCA GTGGCCAGGCTGAGAGCTTAGCAGTTAAAATTCACAACATCTTGTATCCCTATCGTTTCACCAAAGGAATGATTCATTCAATGCAGGTTCTCCAGCAAGT AGATAACAAGTTTATTGCCTGTTTGATGAGCACTAAGACTGAAGAGAATGGCGAGGCAGATTCCTACGAGAAGCAACAGGCACAAGGCTCTGGTCGGAAA AAATTACTGTCTTCTACTCTAATTCCTCCGCTAGAGATAACAGTGACAGAGGAACAAAGGAGACTCTTATGGTGTTACCACAAAAATCTGGAAGATCTGG GCCTTGAATTTGTATTTCCAGACACTAGTGATTCTCTGGTCCTTGTGGGAAAAGTACCACTATGTTTTGTGGAAAGAGAAGCCAATGAACTTCGGAGAGG AAGATCTACTGTGACCAAGAGTATTGTGGAGGAATTTATCCGAGAACAACTGGAGCTACTCCAGACCACCGGAGGCATCCAAGGGACATTGCCACTGACT GTCCAGAAGGTGTTGGCATCCCAAGCCTGCCATGGGGCCATTAAGTTTAATGATGGCCTGAGCTTACAGGAAAGTTGCCGCCTTATTGAAGCTCTGTCCT CATGCCAGCTGCCATTCCAGTGTGCTCACGGGAGACCTTCTATGCTGCCGTTAGCTGACATAGACCACTTGGAACAGGAAAAACAGATTAAACCCAACCT CACTAAACTTCGCAAAATGGCCCAGGCCTGGCGTCTCTTTGGAAAAGCAGAGTGTGATACAAGGCAGAGCCTGCAGCAATCCATGCCTCCCTGTGAGCCA CCATGAGAACAGAATCACTGGTCTAAAAGGAACAAAGGGATGTTCACTGTATGCCTCTGAGCAGAGAGCAGCAGCAGCAGGTACCAGCACGGCCCTGACT GAATCAGCCCAGTGTCCCTGAGCAGCTTAGACAGCAGGGCTCTCTGTATCAGTCTTTCTTGAGCAGATGATTCCCCTAGTTGAGTAGCCAGATGAAATTC AAGCCTAAAGACAATTCATTCATTTGCATCCATGGGCACAGAAGGTTGCTATATAGTATCTACCTTTTGCTACTTATTTAATGATAAAATTTAATGACAG TTTGATTGGTTGCTTGGTTTGTTATTTGAAGGGTGTGATTTTTGTTTTTGTACAGTTTTTTTTCAAGCTTCACATTTGCGTGTATCTAATTCAGCTGATG CTCAAGTCCAAGGGGTAGTCTGCCTTCCCAGGCTGCCCCCAGGGTTTCTGCACTGGTCCCCTCTTTTCCCTTCAGTCTTCTTCACTTCCCTATGCTGCTG CTTCATGTGCTACATCTCAGACTTAAAGAGTTTCTCTACTACAGTGAAAACATTCTCTAGGGTCTTTCATCAGGCCTTTAGTTATTTTAGGGATAAAAAC TATTGATAAAAAGGACAAGGATAGAACAGAGAAAATTTAAAGTCCTGTTCCGGGTTTTTTGTTATGTTTTCTTTAAAAACTCAGAGACTGATGTTCAATA TCCCAAACCAGTAAAATGGTGAAAATACTATGAGCTTGTTTTTTAAAATATGATTTTTTTTGGTACTTTATAAAGTATCTCTTTATGTGAAAGCAATTGT CATATCAAAACACAGCATACATACGTTCAACCTAACCAAATATCTTTACACTTTTTCTTTCAGGAGACAAGGGTTCTTTGGGTCCCTTTCAAACGGTATC TTGGTGTTATTACATTATGCCTATCTATTGCCCTTATAATATCACTTGGGACCAGGACTGATCGTTCTGCAAATGCTTGTTATGCCATTCTCAATCTATT TTTCCCGCACCTTTTCACATGATTTGTGGTTAATAGGACTCAACAGACTAAAATTGCATAGTAGAAAAAAAATGCAAAAAGCCAGCTGGTAATGTTTATT GCAACTGGGGTGCTATACAATTAGTAAGATGATGCAATGAGAATTTCTACTTTTGTATTTCCTGACCAGCCTGCTCAAAGTGGCTTTTATATCAATTGAA TGATTTTCCTCATTTTTTAATACAGGAAACCAATTCGTGCTCATGGAAGAAAAGTTCCTTTGCCAGCAGCCTTGAAGTGAATCTTACAGGAGCAATGAAA GTATTGCATTCATTAGCGTCTGCCCCAGAGAAGGTTCAGAGAAAACCTTCACTTGTTTTCAAGGGGATCCTTGTAGATTTACGTAATTGGAATCCTGAAG AACAGGCCCTACTGTCTAAAAAATGGCTTTTATTCTTCTAAATACATATAAACGGATGTTTTATAGATGGGAAGACATGACCTTAGAAAGGAGAGAGTTT TCAGAGGATTTGCCAGGCTGTCAGGGGCTCTGCCTCCAGGCCCAGTGTGGCAGTGTGGCCTCAGGGCCTCCGCCTCCCTGCTTGAGGGCTGCATGGAGGC CAACTGTCCTGGGAGTTGTAAAAATCTTTTAAGGCCAGACCAATTTGAGGGATTTTAAAAAGTGTCTCAGTGCCTCTTATGATTTCAGAAGGTTTTGCTA TATGTAATCCCAACTACTGTTTTCTTGAGAGTAGCAGAGGATTAGAAAAAGTCCTCCATAAATTATGTAACCGGCCTTCCTGACTAGCCTGACTCAAGCA ATGTAAGAGATAATTATTCTGTTTTCATAATTTATAAGTGTGGGGGCATGCCTCAGCATAAAAACAACCTATTAGGGAAAAATATCTAATAGATTACCTT TATCGCCTGTTAGGGTTTTATGTTGTTTTTAACTCAGATGCCATAAGAACAAAGATACATGTAATTTATAATAGTAATCATTAATACCTATATTGTGCTT TAAGGTTTACAAAATAATTTTTCTCATACTTTATCTTAGTTTAGTTTCTTGACAGTCCATGAGGTAAGGTGGTAGCTTTATCACCATTTTACAAAGTGGG AAACGAAGGTTCCTCTTAGGAACCTAGTTGTCACCTTTGTATAATAAAACTTCGAAGCTCGGAGCTGTTAACTGGTTTGCTGAAGGCTTAGCTGTAAGAG CCAGAATTCAGACCCAGGTCTGAGTGACTTCAAACTGCACAGTCCTTCCCATTATTACCCATATGCTATCCCTTATATTTTTAATTTATTAGGAATTCAT TCATTTATAAACTTGGTGATTCACCTTTATTAGATTCTGGTCGCTGAAGGCTTTAGTAACTTCAGAGTAAAACTTGAGAGATGAGATGTAAAATGCAGCC ATTCTTGAGAGTTCCTTTTTCTGTAACATTCATCAACACTTCATTGAGAAGTGAAGGTTCCTATGGCTGTCTCTACCTTCAAGAGGCTTAGCTTTAGTCA CTGAGAAAGACAAGGAAACTAATGATAGAATATAGTAGCTTCTTCTGGCGTTAGGTATCACAGAGTCACAGCTAGTTACAGCTAGCCCTTTATTATTGAA AGAAGAGGAGCTAGCAGTCCCACTATCAGAATTAAGACTAGAGATGGTAATAGGAGCTAGTATCAGAAAAGCTTAAGGCAAAGCATAAAGTGTAGGCTAG AATGAAGCTGGAGAATGGGGAGGGGGCTTGGGTAACATCCAGAACCTGGCTGGGGACCTGGAACTACATGAGATGTAAGAATGGAGAGGTTCTAGCAGTC AGAGGTCAGGTACAAATGAACAGCTGGGATCTGCGCATGGCAGACAGTGAAAAAACCCAGGCAAGCAAAATGGTCAGAGCAGAAAGGGGCCCAAGGCCAC GTTCTTGAGATGTGGAGGGGGCTGAGGAAGCCACGCCAAGTAAGGACAGATGCAGCTCAGCAGTTCCTAGCGAGCCCTGACAAGCCAGCTCAGCTGAAGC TTCGGGTGGGAGCCAGTCATGGCACAGTGGAGTGAAGGAAGAGCAGTTTCAGGCACCCAAAACCTGACCCCCACGACCTGTTTTCCACCTGAAGAGCCAC CCATTCCATCCAAACCCTTGGCAAAAGTCTGCTAACAGAGAGAACCGGCCAGTATGCTGGCCAGTCGCGATCATGCCTGTCTTTACCCTCTAAGCTGAAG CTGCTCATCAACGGTGAGATGGCAAAAAGGTGGGTCCAGAAGAGGGGAAAAGAAGGGAGTCTGTGAAAACAAAATGCTGAAGAATCTGCATCAAATAAAC CCTTCCTTCCTTCCTTTTTCCTTC

refseq_MLH3.F1 (forward primer)
refseq_MLH3.R1 (reverse primer)
Single exon skipping

Frame 0

NNWCACALVSRGLARPLRSACSWARTSLKIQGA RVGVRGGWCRRIC*AGLQAIISSQRRKPVPGILT IFLPTMIKCLSVEVQAKLRSGLAISSLGQCVEE LALNSIDAEAKCVAVRVNMETFQVQVIDNGFGM GSDDVEKVGNRYFTSKCHSVQDLENPRFYGFRGE ALANIADMASAVEISSKKNRTMKTFVKLFQSGK ALKACEADVTRASAGTTVTVYNLFYQLPVRRKC MDPRLEFEKVRQRIEALSLMHPSISFSLRNDVSG SMVLQLPKTKDVCSRFCQIYGLGKSQKLREISF KYKEFELSGYISSEAHYNKNMQFLFVNKRLVLR TKLHKLIDFLLRKESIICKPKNGPTSRQMNSSLR HRSTPELYGIYVINVQCQFCEYDVCMEPAKTLI EFQNWDTLLFCIQEGVKMFLKQEKLFVELSGED IKEFSEDNGFSLFDATLQKRVTSDERSNFQEACN NILDSYEMFNLQSKAVKRKTTAENVNTQSSRDS EATRKNTNDAFLYIYESGGPGHSKMTEPSLQNK DSSCSESKMLEQETIVASEAGENEKHKKSFLEHS SLENPCGTSLEMFLSPFQTPCHFEESGQDLEIW KESTTVNGMAANILKNNRIQNQPKRFKDATEVG CQPLPFATTLWGVHSAQTEKEKKKESSNCGRRNV FSYGRVKLCSTGFITHVVQNEKTKSTETEHSFK NYVRPGPTRAQETFGNRTRHSVETPDIKDLAST LSKESGQLPNKKNCRTNISYGLENEPTATYTMFS AFQEGSKKSQTDCILSDTSPSFPWYRHVSNDSR KTDKLIGFSKPIVRKKLSLSSQLGSLEKFKRQY GKVENPLDTEVEESNGVTTNLSLQVEPDILLKDK NRLENSDVCKITTMEHSDSDSSCQPASHILNSE KFPFSKDEDCLEQQMPSLRESPMTLKELSLFNR KPLDLEKSSESLASKLSRLKGSERETQTMGMMSR FNELPNSDSSRKDSKLCSVLTQDFCMLFNNKHE KTENGVIPTSDSATQDNSFNKNSKTHSNSNTTE NCVISETPLVLPYNNSKVTGKDSDVLIRASEQQI GSLDSPSGMLMNPVEDATGDQNGICFQSEESKA RACSETEESNTCCSDWQRHFDVALGRMVYVNKM TGLSTFIAPTEDIQAACTKDLTTVAVDVVLENGS QYRCQPFRSDLVLPFLPRARAERTVMRQDNRDT VDDTVSSESLQSLFSEWDNPVFARYPEVAVDVS SGQAESLAVKIHNILYPYRFTKGMIHSMQVLQQV DNKFIACLMSTKTEENGEADSYEKQQAQGSGRK KLLSSTLIPPLEITVTEEQRRLLWCYHKNLEDL GLEFVFPDTSDSLVLVGKVPLCFVEREANELRRG RSTVTKSIVEEFIREQLELLQTTGGIQGTLPLT VQKVLASQACHGAIKFNDGLSLQESCRLIEALS SCQLPFQCAHGRPSMLPLADIDHLEQEKQIKPNL TKLRKMAQAWRLFGKAECDTRQSLQQSMPPCEP P*EQNHWSKRNKGMFTVCL*AESSSSRYQHGPD *ISPVSLSSLDSRALCISLS*ADDSPS*VAR*NS SLKTIHSFASMGTEGCYIVSTFCYLFNDKI**Q FDWLLGLLFEGCDFCFCTVFFQASHLRVSNSAD AQVQGVVCLPRLPPGFLHWSPLFPSVFFTSLCCC FMCYISDLKSFSTTVKTFSRVFHQAFSYFRDKN Y**KGQG*NRENLKSCSGFFVMFSLKTQRLMFN IPNQ*NGENTMSLFFKI*FFLVLYKVSLYVKAIV ISKHSIHTFNLTKYLYTFSFRRQGFFGSLSNGI LVLLHYAYLLPL*YHLGPGLIVLQMLVMPFSIY FSRTFSHDLWLIGLNRLKLHSRKKMQKASW*CLL QLGCYTISKMMQ*EFLLLYFLTSLLKVAFISIE *FSSFFNTGNQFVLMEEKFLCQQP*SESYRSNE SIAFISVCPREGSEKTFTCFQGDPCRFT*LES*R TGPTV*KMAFILLNTYKRMFYRWEDMTLERREF SEDLPGCQGLCLQAQCGSVASGPPPPCLRAAWR PTVLGVVKIF*GQTNLRDFKKCLSASYDFRRFCY M*SQLLFS*E*QRIRKSPP*IM*PAFLTSLTQA M*EIIILFS*FISVGACLSIKTTY*GKISNRLP LSPVRVLCCF*LRCHKNKDTCNL***SLIPILCF KVYKIIFLILYLSLVS*QSMR*GGSFITILQSG KRRFLLGT*LSPLYNKTSKLGAVNWFAEGLAVR ARIQTQV*VTSNCTVLPIITHMLSLIFLIY*EFI HL*TW*FTFIRFWSLKALVTSE*NLRDEM*NAA ILESSFFCNIHQHFIEK*RFLWLSLPSRGLALV TEKDKETNDRI**LLLALGITESQLVTASPLLLK EEELAVPLSELRLEMVIGASIRKA*GKA*SVG* NEAGEWGGGLGNIQNLAGDLELHEM*EWRGSSS QRSGTNEQLGSAHGRQ*KNPGKQNGQSRKGPKAT FLRCGGG*GSHAK*GQMQLSSS*RALTSQLS*S FGWEPVMAQWSEGRAVSGTQNLTPTTCFPPEEP PIPSKPLAKVC*QREPASMLASRDHACLYPLS*S CSSTVRWQKGGSRRGEKKGVCENKMLKNLHQIN PSFLPFSF

Frame 1

TTGAHAHWCLAAWRAPSEAHARGHARASRSKVR ASASEAVGVGEFVKRDSRQLFPVREGNQCLAFS PSFYLP*SSACQLKYKPNCVLVWP*APWANVLRN LPSTVLMLKQNVWLSG*IWKPSKFK**TMDLGW GVMM*RKWEIVISPVNATRYRTWRIQGFMVSEE RPWQILLTWPVLWKFRPRKTGQ*KLL*NCFRVEK P*KLVKLM*LEQALGLL*QCITYFTSFL*GGNA WTLDWSLRRLGRE*KLSHSCTLPFLSL*EMMFL VPWFFSSLKPKTYVPDFVKFMDWESPKS*EK*VL NIKSLSLVAISALKHITTRICSFCL*TKD*F*G QSYINSLTFY*GKKVLYASQRMVPPVGK*IQVF GTGLPQNSMAYM*LMCSANSVSMMCAWSQPKL*L NFRTGTLSCFAFRKE*KCF*SKKNYLWNYQVRI LRNLVKIMVLVYLMLLFRSV*LPMRGAISRKHV IIF*IPMRCLICSQKL*KEKLLQKT*THRVLGIQ KLPEKIQMMHFCTFMNQVVQAIAK*QSHLYKTK TALAQNQRC*NKRQL*HQKLEKMRNIKNLSWNI AL*KIRVEPV*KCF*ALFRHHVTLRRVGRI*KYG KKVLLLMAWLPTS*KIIEFRINQRDLKMLLKWD ASLCLLQQHYGEYIVLRQRKRKKKNLAIVEEEM FLVMGELNYVPLAL*LM*YKMKKLNQLKQNIHLK IMLDLVPHVPKKHLEIEHVIQLKLQTSKI*PAL *VKNLVNCPTKKIAERI*VMG*RMNLQQLIQCF LLFRKVAKNHKQIAYYLIHPPLSPGIDTFPMIVG KQIN*LVSPNQSSVRS*A*VHS*DL*RSLRGNM GRLKILWIQK*RKVMESLPISVFKLNLTFC*RT RTA*RTLMFVKSLLWSIVIQIVVVNQQATSLTQR SFHSPRMKIV*NNRCLV*EKVL*P*RSYLSLIE NLWTLRSHLNH*PLNYPD*RVPKEKLKQWG**V VLMNFQIQIPVGKTASCAVC*HKIFVCYLTTSMK KQRMVSSQHQILPHRIIPLIKIVKHILTAIQQR TV*YQKLLWYCPIIILKLPVKIQMFLSEPQNNR *EVLTLPVEC**IR*KMPQVTKMEFVFRVRNLKQ ELVLKLKSQTRVVQIGSGISM*PWEEWFMSTK* LDSAHSLPQLRTFRLLVLKT*QLWLWMLYLRMG LSTGVNLLEATLFFLSFRELEQRGL**DRITEIL WMILLVANRFSLCSQNGTIQYLPVIQRLLLM*A VARLRA*QLKFTTSCIPIVSPKE*FIQCRFSSK *ITSLLPV**ALRLKRMARQIPTRSNRHKALVGK NYCLLL*FLR*R*Q*QRNKGDSYGVTTKIWKIW ALNLYFQTLVILWSLWEKYHYVLWKEKPMNFGE EDLL*PRVLWRNLSENNWSYSRPPEASKGHCH*L SRRCWHPKPAMGPLSLMMA*AYRKVAALLKLCP HASCHSSVLTGDLLCCR*LT*TTWNRKNRLNPT SLNFAKWPRPGVSLEKQSVIQGRACSNPCLPVSH HENRITGLKGTKGCSLYASEQRAAAAGTSTALT ESAQCP*AA*TAGLSVSVFLEQMIPLVE*PDEI QA*RQFIHLHPWAQKVAI*YLPFATYLMIKFNDS LIGCLVCYLKGVIFVFVQFFFKLHICVYLIQLM LKSKG*SAFPGCPQGFCTGPLFSLQSSSLPYAA ASCATSQT*RVSLLQ*KHSLGSFIRPLVILGIKT IDKKDKDRTEKI*SPVPGFLLCFL*KLRD*CSI SQTSKMVKIL*ACFLKYDFFWYFIKYLFM*KQL SYQNTAYIRST*PNIFTLFLSGDKGSLGPFQTVS WCYYIMPIYCPYNITWDQD*SFCKCLLCHSQSI FPAPFHMICG**DSTD*NCIVEKKCKKPAGNVY CNWGAIQLVR*CNENFYFCIS*PACSKWLLYQLN DFPHFLIQETNSCSWKKSSFASSLEVNLTGAMK VLHSLASAPEKVQRKPSLVFKGILVDLRNWNPE EQALLSKKWLLFF*IHINGCFIDGKT*P*KGESF QRICQAVRGSASRPSVAVWPQGLRLPA*GLHGG QLSWEL*KSFKARPI*GILKSVSVPLMISEGFA ICNPNYCFLESSRGLEKVLHKLCNRPS*LA*LKQ CKR*LFCFHNL*VWGHASA*KQPIREKYLIDYL YRLLGFYVVFNSDAIRTKIHVIYNSNH*YLYCA LRFTK*FFSYFILV*FLDSP*GKVVALSPFYKVG NEGSS*EPSCHLCIIKLRSSELLTGLLKA*L*E PEFRPRSE*LQTAQSFPLLPICYPLYF*FIRNS FIYKLGDSPLLDSGR*RL**LQSKT*EMRCKMQP FLRVPFSVTFINTSLRSEGSYGCLYLQEA*L*S LRKTRKLMIEYSSFFWR*VSQSHS*LQLALYY* KKRS*QSHYQN*D*RW**ELVSEKLKAKHKV*AR MKLENGEGAWVTSRTWLGTWNYMRCKNGEVLAV RGQVQMNSWDLRMADSEKTQASKMVRAERGPRP RS*DVEGAEEATPSKDRCSSAVPSEP*QASSAEA SGGSQSWHSGVKEEQFQAPKT*PPRPVFHLKSH PFHPNPWQKSANRENRPVCWPVAIMPVFTL*AE AAHQR*DGKKVGPEEGKRRESVKTKC*RICIK*T LPSFLFP

Frame 2

QLVRMRTGVSRPGAPPPKRMLVGTHEPQDPRCA RRRPRRLVSENLLSGTPGNYFQSEKETSAWHSH HLSTYHDQVLVS*STSQIAFWFGHKLLGPMC*G TCPQQY*C*SKMCGCQGEYGNLPSSSDRQWIWDG E**CRESGKSLFHQ*MPLGTGLGESKVLWFPRR GLGKYC*HGQCCGNFVQEKQDNENFCETVSEWK SPESL*S*CD*SKRWDYCNSV*PILPASCKEEMH GP*TGV*EG*AENRSSLTHAPFHFFLFEK*CFW FHGSSAP*NQRRMFPILSNLWIGKVPKAKRNKF *I*RV*A*WLYQL*STLQQEYAVFVCEQKTSFKD KAT*TH*LFIKERKYYMQAKEWSHQ*ANEFKSS APVYPRTLWHICN*CAVPIL*V*CVHGASQNSD *ISELGHSLVLHSGRSENVFKARKIICGIIR*GY *GI**R*WF*FI*CYSSEACDFR*EEQFPGSM* *YFRFL*DV*FAVKSCEKKNYCRKRKHTEF*GF RSYQKKYK*CIFVHL*IRWSRP*QNDRAIFTKQR QLLLRIKDVRTRDNCSIRSWRK*ET*KIFPGT* LFRKSVWNQFRNVFKPFSDTMSL*GEWAGSRNM ERKYYC*WHGCQHLEK**NSESTKEI*RCY*SGM PASAFCNNIMGST*CSDREREKKRI*QLWKKKC F*LWAS*IMFHWLYNSCSTK*KN*IN*NRTFI* KLC*TWSHTCPRNIWK*NTSFS*NSRHQRFSQHF K*RIWSIAQQKKLQNEYKLWARE*TYSNLYNVF CFSGR*QKITNRLHII*YIPLFPLV*TRFQ*** ENR*INWFLQTNRP*EAKLEFTARIFREV*EAIW EG*KSSGYRSRGK*WSHYQSQSSS*T*HSAEGQ EPLREL*CL*NHYYGA**FR**LSTSKPHP*LR EVSILQG*RLFRTTDA*FERKSYDPEGVISL**K TFGP*EVI*ITSL*IIQTEGFRKRNSNNGDDES F**TSKFRFQ*ERQQVVQCVNTRFLYVI*QQA* KNREWCHPNIRFCHTG*FL**K**NTF*QQYNRE LCDIRNSFGIAL**F*SYR*RFRCSYQSLRTTD RKS*LSQWNVNESGRRCHR*PKWNLFSE*GI*S KSLF*N*RVKHVLFRLAAAFRCSPGKNGLCQQND WTQHIHCPN*GHSGCLY*RPDNCGCGCCT*EWV SVQVSTF*KRPCSSFPSESSSREDCDETG*QRY CG*YC**RIASVFVLRMGQSSICPLSRGCC*CKQ WPG*ELSS*NSQHLVSLSFHQRNDSFNAGSPAS R*QVYCLFDEH*D*REWRGRFLREATGTRLWSE KITVFYSNSSARDNSDRGTKETLMVLPQKSGRSG P*ICISRH**FSGPCGKSTTMFCGKRSQ*TSER KIYCDQEYCGGIYPRTTGATPDHRRHPRDIATD CPEGVGIPSLPWGH*V**WPELTGKLPPY*SSVL MPAAIPVCSRETFYAAVS*HRPLGTGKTD*TQP H*TSQNGPGLASLWKSRV*YKAEPAAIHASL*A TMRTESLV*KEQRDVHCMPLSREQQQQVPARP*L NQPSVPEQLRQQGSLYQSFLSR*FP*LSSQMKF KPKDNSFICIHGHRRLLYSIYLLLLI***NLMT V*LVAWFVI*RV*FLFLYSFFSSFTFACI*FS*C SSPRGSLPSQAAPRVSALVPSFPFSLLHFPMLL LHVLHLRLKEFLYYSENIL*GLSSGL*LF*G*K LLIKRTRIEQRKFKVLFRVFCYVFFKNSETDVQY PKPVKW*KYYELVF*NMIFFGTL*SISLCESNC HIKTQHTYVQPNQISLHFFFQETRVLWVPFKRY LGVITLCLSIALIISLGTRTDRSANACYAILNLF FPHLFT*FVVNRTQQTKIA**KKNAKSQLVMFI ATGVLYN**DDAMRISTFVFPDQPAQSGFYIN* MIFLIF*YRKPIRAHGRKVPLPAALK*ILQEQ*K YCIH*RLPQRRFRENLHLFSRGSL*IYVIGILK NRPYCLKNGFYSSKYI*TDVL*MGRHDLRKERV FRGFARLSGALPPGPVWQCGLRASASLLEGCMEA NCPGSCKNLLRPDQFEGF*KVSQCLL*FQKVLL YVIPTTVFLRVAED*KKSSINYVTGLPD*PDSS NVRDNYSVFIIYKCGGMPQHKNNLLGKNI**ITF IAC*GFMLFLTQMP*EQRYM*FIIVIINTYIVL *GLQNNFSHTLS*FSFLTVHEVRW*LYHHFTKW ETKVPLRNLVVTFV**NFEARSC*LVC*RLSCKS QNSDPGLSDFKLHSPSHYYPYAIPYIFNLLGIH SFINLVIHLY*ILVAEGFSNFRVKLER*DVKCS HS*EFLFL*HSSTLH*EVKVPMAVSTFKRLSFSH *ERQGN***NIVASSGVRYHRVTASYS*PFIIE RRGASSPTIRIKTRDGNRS*YQKSLRQSIKCRL E*SWRMGRGLG*HPEPGWGPGTT*DVRMERF*QS EVRYK*TAGICAWQTVKKPRQAKWSEQKGAQGH VLEMWRGLRKPRQVRTDAAQQFLASPDKPAQLK LRVGASHGTVE*RKSSFRHPKPDPHDLFST*RAT HSIQTLGKSLLTERTGQYAGQSRSCLSLPSKLK LLINGEMAKRWVQKRGKEGSL*KQNAEESASNK PFLPSFFL

Sequence NM_001040108

AACAACTGGTGCGCATGCGCACTGGTGTCTCGCGGCCTGGCGCGCCCCCTCCGAAGCGCATGCTCGTGGGCACGCACGAGCCTCAAGATCCAAGGTGCGC GCGTCGGCGTCCGAGGCGGTTGGTGTCGGAGAATTTGTTAAGCGGGACTCCAGGCAATTATTTCCAGTCAGAGAAGGAAACCAGTGCCTGGCATTCTCAC CATCTTTCTACCTACCATGATCAAGTGCTTGTCAGTTGAAGTACAAGCCAAATTGCGTTCTGGTTTGGCCATAAGCTCCTTGGGCCAATGTGTTGAGGAA CTTGCCCTCAACAGTATTGATGCTGAAGCAAAATGTGTGGCTGTCAGGGTGAATATGGAAACCTTCCAAGTTCAAGTGATAGACAATGGATTTGGGATGG GGAGTGATGATGTAGAGAAAGTGGGAAATCGTTATTTCACCAGTAAATGCCACTCGGTACAGGACTTGGAGAATCCAAGGTTTTATGGTTTCCGAGGAGA GGCCTTGGCAAATATTGCTGACATGGCCAGTGCTGTGGAAATTTCGTCCAAGAAAAACAGGACAATGAAAACTTTTGTGAAACTGTTTCAGAGTGGAAAA GCCCTGAAAGCTTGTGAAGCTGATGTGACTAGAGCAAGCGCTGGGACTACTGTAACAGTGTATAACCTATTTTACCAGCTTCCTGTAAGGAGGAAATGCA TGGACCCTAGACTGGAGTTTGAGAAGGTTAGGCAGAGAATAGAAGCTCTCTCACTCATGCACCCTTCCATTTCTTTCTCTTTGAGAAATGATGTTTCTGG TTCCATGGTTCTTCAGCTCCCTAAAACCAAAGACGTATGTTCCCGATTTTGTCAAATTTATGGATTGGGAAAGTCCCAAAAGCTAAGAGAAATAAGTTTT AAATATAAAGAGTTTGAGCTTAGTGGCTATATCAGCTCTGAAGCACATTACAACAAGAATATGCAGTTTTTGTTTGTGAACAAAAGACTAGTTTTAAGGA CAAAGCTACATAAACTCATTGACTTTTTATTAAGGAAAGAAAGTATTATATGCAAGCCAAAGAATGGTCCCACCAGTAGGCAAATGAATTCAAGTCTTCG GCACCGGTCTACCCCAGAACTCTATGGCATATATGTAATTAATGTGCAGTGCCAATTCTGTGAGTATGATGTGTGCATGGAGCCAGCCAAAACTCTGATT GAATTTCAGAACTGGGACACTCTCTTGTTTTGCATTCAGGAAGGAGTGAAAATGTTTTTAAAGCAAGAAAAATTATTTGTGGAATTATCAGGTGAGGATA TTAAGGAATTTAGTGAAGATAATGGTTTTAGTTTATTTGATGCTACTCTTCAGAAGCGTGTGACTTCCGATGAGAGGAGCAATTTCCAGGAAGCATGTAA TAATATTTTAGATTCCTATGAGATGTTTAATTTGCAGTCAAAAGCTGTGAAAAGAAAAACTACTGCAGAAAACGTAAACACACAGAGTTCTAGGGATTCA GAAGCTACCAGAAAAAATACAAATGATGCATTTTTGTACATTTATGAATCAGGTGGTCCAGGCCATAGCAAAATGACAGAGCCATCTTTACAAAACAAAG ACAGCTCTTGCTCAGAATCAAAGATGTTAGAACAAGAGACAATTGTAGCATCAGAAGCTGGAGAAAATGAGAAACATAAAAAATCTTTCCTGGAACATAG CTCTTTAGAAAATCCGTGTGGAACCAGTTTAGAAATGTTTTTAAGCCCTTTTCAGACACCATGTCACTTTGAGGAGAGTGGGCAGGATCTAGAAATATGG AAAGAAAGTACTACTGTTAATGGCATGGCTGCCAACATCTTGAAAAATAATAGAATTCAGAATCAACCAAAGAGATTTAAAGATGCTACTGAAGTGGGAT GCCAGCCTCTGCCTTTTGCAACAACATTATGGGGAGTACATAGTGCTCAGACAGAGAAAGAGAAAAAAAAAGAATCTAGCAATTGTGGAAGAAGAAATGT TTTTAGTTATGGGCGAGTTAAATTATGTTCCACTGGCTTTATAACTCATGTAGTACAAAATGAAAAAACTAAATCAACTGAAACAGAACATTCATTTAAA AATTATGTTAGACCTGGTCCCACACGTGCCCAAGAAACATTTGGAAATAGAACACGTCATTCAGTTGAAACTCCAGACATCAAAGATTTAGCCAGCACTT TAAGTAAAGAATCTGGTCAATTGCCCAACAAAAAAAATTGCAGAACGAATATAAGTTATGGGCTAGAGAATGAACCTACAGCAACTTATACAATGTTTTC TGCTTTTCAGGAAGGTAGCAAAAAATCACAAACAGATTGCATATTATCTGATACATCCCCCTCTTTCCCCTGGTATAGACACGTTTCCAATGATAGTAGG AAAACAGATAAATTAATTGGTTTCTCCAAACCAATCGTCCGTAAGAAGCTAAGCTTGAGTTCACAGCTAGGATCTTTAGAGAAGTTTAAGAGGCAATATG GGAAGGTTGAAAATCCTCTGGATACAGAAGTAGAGGAAAGTAATGGAGTCACTACCAATCTCAGTCTTCAAGTTGAACCTGACATTCTGCTGAAGGACAA GAACCGCTTAGAGAACTCTGATGTTTGTAAAATCACTACTATGGAGCATAGTGATTCAGATAGTAGTTGTCAACCAGCAAGCCACATCCTTAACTCAGAG AAGTTTCCATTCTCCAAGGATGAAGATTGTTTAGAACAACAGATGCCTAGTTTGAGAGAAAGTCCTATGACCCTGAAGGAGTTATCTCTCTTTAATAGAA AACCTTTGGACCTTGAGAAGTCATCTGAATCACTAGCCTCTAAATTATCCAGACTGAAGGGTTCCGAAAGAGAAACTCAAACAATGGGGATGATGAGTCG TTTTAATGAACTTCCAAATTCAGATTCCAGTAGGAAAGACAGCAAGTTGTGCAGTGTGTTAACACAAGATTTTTGTATGTTATTTAACAACAAGCATGAA AAAACAGAGAATGGTGTCATCCCAACATCAGATTCTGCCACACAGGATAATTCCTTTAATAAAAATAGTAAAACACATTCTAACAGCAATACAACAGAGA ACTGTGTGATATCAGAAACTCCTTTGGTATTGCCCTATAATAATTCTAAAGTTACCGGTAAAGATTCAGATGTTCTTATCAGAGCCTCAGAACAACAGAT AGGAAGTCTTGACTCTCCCAGTGGAATGTTAATGAATCCGGTAGAAGATGCCACAGGTGACCAAAATGGAATTTGTTTTCAGAGTGAGGAATCTAAAGCA AGAGCTTGTTCTGAAACTGAAGAGTCAAACACGTGTTGTTCAGATTGGCAGCGGCATTTCGATGTAGCCCTGGGAAGAATGGTTTATGTCAACAAAATGA CTGGACTCAGCACATTCATTGCCCCAACTGAGGACATTCAGGCTGCTTGTACTAAAGACCTGACAACTGTGGCTGTGGATGTTGTACTTGAGAATGGGTC TCAGTACAGGTGTCAACCTTTTAGAAGCGACCTTGTTCTTCCTTTCCTTCCGAGAGCTCGAGCAGAGAGGACTGTGATGAGACAGGATAACAGAGATACT GTGGATGATACTGTTAGTAGCGAATCGCTTCAGTCTTTGTTCTCAGAATGGGACAATCCAGTATTTGCCCGTTATCCAGAGGTTGCTGTTGATGTAAGCA GTGGCCAGGCTGAGAGCTTAGCAGTTAAAATTCACAACATCTTGTATCCCTATCGTTTCACCAAAGGAATGATTCATTCAATGCAGGTTCTCCAGCAAGT AGATAACAAGTTTATTGCCTGTTTGATGAGCACTAAGACTGAAGAGAATGGCGAGGCAGGTGGGAACCTGCTCGTGCTGGTGGATCAGCACGCTGCCCAT GAGCGTATACGTCTGGAGCAGCTTATCATTGATTCCTACGAGAAGCAACAGGCACAAGGCTCTGGTCGGAAAAAATTACTGTCTTCTACTCTAATTCCTC CGCTAGAGATAACAGTGACAGAGGAACAAAGGAGACTCTTATGGTGTTACCACAAAAATCTGGAAGATCTGGGCCTTGAATTTGTATTTCCAGACACTAG TGATTCTCTGGTCCTTGTGGGAAAAGTACCACTATGTTTTGTGGAAAGAGAAGCCAATGAACTTCGGAGAGGAAGATCTACTGTGACCAAGAGTATTGTG GAGGAATTTATCCGAGAACAACTGGAGCTACTCCAGACCACCGGAGGCATCCAAGGGACATTGCCACTGACTGTCCAGAAGGTGTTGGCATCCCAAGCCT GCCATGGGGCCATTAAGTTTAATGATGGCCTGAGCTTACAGGAAAGTTGCCGCCTTATTGAAGCTCTGTCCTCATGCCAGCTGCCATTCCAGTGTGCTCA CGGGAGACCTTCTATGCTGCCGTTAGCTGACATAGACCACTTGGAACAGGAAAAACAGATTAAACCCAACCTCACTAAACTTCGCAAAATGGCCCAGGCC TGGCGTCTCTTTGGAAAAGCAGAGTGTGATACAAGGCAGAGCCTGCAGCAATCCATGCCTCCCTGTGAGCCACCATGAGAACAGAATCACTGGTCTAAAA GGAACAAAGGGATGTTCACTGTATGCCTCTGAGCAGAGAGCAGCAGCAGCAGGTACCAGCACGGCCCTGACTGAATCAGCCCAGTGTCCCTGAGCAGCTT AGACAGCAGGGCTCTCTGTATCAGTCTTTCTTGAGCAGATGATTCCCCTAGTTGAGTAGCCAGATGAAATTCAAGCCTAAAGACAATTCATTCATTTGCA TCCATGGGCACAGAAGGTTGCTATATAGTATCTACCTTTTGCTACTTATTTAATGATAAAATTTAATGACAGTTTGATTGGTTGCTTGGTTTGTTATTTG AAGGGTGTGATTTTTGTTTTTGTACAGTTTTTTTTCAAGCTTCACATTTGCGTGTATCTAATTCAGCTGATGCTCAAGTCCAAGGGGTAGTCTGCCTTCC CAGGCTGCCCCCAGGGTTTCTGCACTGGTCCCCTCTTTTCCCTTCAGTCTTCTTCACTTCCCTATGCTGCTGCTTCATGTGCTACATCTCAGACTTAAAG AGTTTCTCTACTACAGTGAAAACATTCTCTAGGGTCTTTCATCAGGCCTTTAGTTATTTTAGGGATAAAAACTATTGATAAAAAGGACAAGGATAGAACA GAGAAAATTTAAAGTCCTGTTCCGGGTTTTTTGTTATGTTTTCTTTAAAAACTCAGAGACTGATGTTCAATATCCCAAACCAGTAAAATGGTGAAAATAC TATGAGCTTGTTTTTTAAAATATGATTTTTTTTGGTACTTTATAAAGTATCTCTTTATGTGAAAGCAATTGTCATATCAAAACACAGCATACATACGTTC AACCTAACCAAATATCTTTACACTTTTTCTTTCAGGAGACAAGGGTTCTTTGGGTCCCTTTCAAACGGTATCTTGGTGTTATTACATTATGCCTATCTAT TGCCCTTATAATATCACTTGGGACCAGGACTGATCGTTCTGCAAATGCTTGTTATGCCATTCTCAATCTATTTTTCCCGCACCTTTTCACATGATTTGTG GTTAATAGGACTCAACAGACTAAAATTGCATAGTAGAAAAAAAATGCAAAAAGCCAGCTGGTAATGTTTATTGCAACTGGGGTGCTATACAATTAGTAAG ATGATGCAATGAGAATTTCTACTTTTGTATTTCCTGACCAGCCTGCTCAAAGTGGCTTTTATATCAATTGAATGATTTTCCTCATTTTTTAATACAGGAA ACCAATTCGTGCTCATGGAAGAAAAGTTCCTTTGCCAGCAGCCTTGAAGTGAATCTTACAGGAGCAATGAAAGTATTGCATTCATTAGCGTCTGCCCCAG AGAAGGTTCAGAGAAAACCTTCACTTGTTTTCAAGGGGATCCTTGTAGATTTACGTAATTGGAATCCTGAAGAACAGGCCCTACTGTCTAAAAAATGGCT TTTATTCTTCTAAATACATATAAACGGATGTTTTATAGATGGGAAGACATGACCTTAGAAAGGAGAGAGTTTTCAGAGGATTTGCCAGGCTGTCAGGGGC TCTGCCTCCAGGCCCAGTGTGGCAGTGTGGCCTCAGGGCCTCCGCCTCCCTGCTTGAGGGCTGCATGGAGGCCAACTGTCCTGGGAGTTGTAAAAATCTT TTAAGGCCAGACCAATTTGAGGGATTTTAAAAAGTGTCTCAGTGCCTCTTATGATTTCAGAAGGTTTTGCTATATGTAATCCCAACTACTGTTTTCTTGA GAGTAGCAGAGGATTAGAAAAAGTCCTCCATAAATTATGTAACCGGCCTTCCTGACTAGCCTGACTCAAGCAATGTAAGAGATAATTATTCTGTTTTCAT AATTTATAAGTGTGGGGGCATGCCTCAGCATAAAAACAACCTATTAGGGAAAAATATCTAATAGATTACCTTTATCGCCTGTTAGGGTTTTATGTTGTTT TTAACTCAGATGCCATAAGAACAAAGATACATGTAATTTATAATAGTAATCATTAATACCTATATTGTGCTTTAAGGTTTACAAAATAATTTTTCTCATA CTTTATCTTAGTTTAGTTTCTTGACAGTCCATGAGGTAAGGTGGTAGCTTTATCACCATTTTACAAAGTGGGAAACGAAGGTTCCTCTTAGGAACCTAGT TGTCACCTTTGTATAATAAAACTTCGAAGCTCGGAGCTGTTAACTGGTTTGCTGAAGGCTTAGCTGTAAGAGCCAGAATTCAGACCCAGGTCTGAGTGAC TTCAAACTGCACAGTCCTTCCCATTATTACCCATATGCTATCCCTTATATTTTTAATTTATTAGGAATTCATTCATTTATAAACTTGGTGATTCACCTTT ATTAGATTCTGGTCGCTGAAGGCTTTAGTAACTTCAGAGTAAAACTTGAGAGATGAGATGTAAAATGCAGCCATTCTTGAGAGTTCCTTTTTCTGTAACA TTCATCAACACTTCATTGAGAAGTGAAGGTTCCTATGGCTGTCTCTACCTTCAAGAGGCTTAGCTTTAGTCACTGAGAAAGACAAGGAAACTAATGATAG AATATAGTAGCTTCTTCTGGCGTTAGGTATCACAGAGTCACAGCTAGTTACAGCTAGCCCTTTATTATTGAAAGAAGAGGAGCTAGCAGTCCCACTATCA GAATTAAGACTAGAGATGGTAATAGGAGCTAGTATCAGAAAAGCTTAAGGCAAAGCATAAAGTGTAGGCTAGAATGAAGCTGGAGAATGGGGAGGGGGCT TGGGTAACATCCAGAACCTGGCTGGGGACCTGGAACTACATGAGATGTAAGAATGGAGAGGTTCTAGCAGTCAGAGGTCAGGTACAAATGAACAGCTGGG ATCTGCGCATGGCAGACAGTGAAAAAACCCAGGCAAGCAAAATGGTCAGAGCAGAAAGGGGCCCAAGGCCACGTTCTTGAGATGTGGAGGGGGCTGAGGA AGCCACGCCAAGTAAGGACAGATGCAGCTCAGCAGTTCCTAGCGAGCCCTGACAAGCCAGCTCAGCTGAAGCTTCGGGTGGGAGCCAGTCATGGCACAGT GGAGTGAAGGAAGAGCAGTTTCAGGCACCCAAAACCTGACCCCCACGACCTGTTTTCCACCTGAAGAGCCACCCATTCCATCCAAACCCTTGGCAAAAGT CTGCTAACAGAGAGAACCGGCCAGTATGCTGGCCAGTCGCGATCATGCCTGTCTTTACCCTCTAAGCTGAAGCTGCTCATCAACGGTGAGATGGCAAAAA GGTGGGTCCAGAAGAGGGGAAAAGAAGGGAGTCTGTGAAAACAAAATGCTGAAGAATCTGCATCAAATAAACCCTTCCTTCCTTCCTTTTTCCTTC

refseq_MLH3.F1 (forward primer)
refseq_MLH3.R1 (reverse primer)
Single exon skipping

Frame 0

NNWCACALVSRGLARPLRSACSWARTSLKIQGA RVGVRGGWCRRIC*AGLQAIISSQRRKPVPGILT IFLPTMIKCLSVEVQAKLRSGLAISSLGQCVEE LALNSIDAEAKCVAVRVNMETFQVQVIDNGFGM GSDDVEKVGNRYFTSKCHSVQDLENPRFYGFRGE ALANIADMASAVEISSKKNRTMKTFVKLFQSGK ALKACEADVTRASAGTTVTVYNLFYQLPVRRKC MDPRLEFEKVRQRIEALSLMHPSISFSLRNDVSG SMVLQLPKTKDVCSRFCQIYGLGKSQKLREISF KYKEFELSGYISSEAHYNKNMQFLFVNKRLVLR TKLHKLIDFLLRKESIICKPKNGPTSRQMNSSLR HRSTPELYGIYVINVQCQFCEYDVCMEPAKTLI EFQNWDTLLFCIQEGVKMFLKQEKLFVELSGED IKEFSEDNGFSLFDATLQKRVTSDERSNFQEACN NILDSYEMFNLQSKAVKRKTTAENVNTQSSRDS EATRKNTNDAFLYIYESGGPGHSKMTEPSLQNK DSSCSESKMLEQETIVASEAGENEKHKKSFLEHS SLENPCGTSLEMFLSPFQTPCHFEESGQDLEIW KESTTVNGMAANILKNNRIQNQPKRFKDATEVG CQPLPFATTLWGVHSAQTEKEKKKESSNCGRRNV FSYGRVKLCSTGFITHVVQNEKTKSTETEHSFK NYVRPGPTRAQETFGNRTRHSVETPDIKDLAST LSKESGQLPNKKNCRTNISYGLENEPTATYTMFS AFQEGSKKSQTDCILSDTSPSFPWYRHVSNDSR KTDKLIGFSKPIVRKKLSLSSQLGSLEKFKRQY GKVENPLDTEVEESNGVTTNLSLQVEPDILLKDK NRLENSDVCKITTMEHSDSDSSCQPASHILNSE KFPFSKDEDCLEQQMPSLRESPMTLKELSLFNR KPLDLEKSSESLASKLSRLKGSERETQTMGMMSR FNELPNSDSSRKDSKLCSVLTQDFCMLFNNKHE KTENGVIPTSDSATQDNSFNKNSKTHSNSNTTE NCVISETPLVLPYNNSKVTGKDSDVLIRASEQQI GSLDSPSGMLMNPVEDATGDQNGICFQSEESKA RACSETEESNTCCSDWQRHFDVALGRMVYVNKM TGLSTFIAPTEDIQAACTKDLTTVAVDVVLENGS QYRCQPFRSDLVLPFLPRARAERTVMRQDNRDT VDDTVSSESLQSLFSEWDNPVFARYPEVAVDVS SGQAESLAVKIHNILYPYRFTKGMIHSMQVLQQV DNKFIACLMSTKTEENGEAGGNLLVLVDQHAAH ERIRLEQLIIDSYEKQQAQGSGRKKLLSSTLIP PLEITVTEEQRRLLWCYHKNLEDLGLEFVFPDTS DSLVLVGKVPLCFVEREANELRRGRSTVTKSIV EEFIREQLELLQTTGGIQGTLPLTVQKVLASQA CHGAIKFNDGLSLQESCRLIEALSSCQLPFQCAH GRPSMLPLADIDHLEQEKQIKPNLTKLRKMAQA WRLFGKAECDTRQSLQQSMPPCEPP*EQNHWSK RNKGMFTVCL*AESSSSRYQHGPD*ISPVSLSSL DSRALCISLS*ADDSPS*VAR*NSSLKTIHSFA SMGTEGCYIVSTFCYLFNDKI**QFDWLLGLLF EGCDFCFCTVFFQASHLRVSNSADAQVQGVVCLP RLPPGFLHWSPLFPSVFFTSLCCCFMCYISDLK SFSTTVKTFSRVFHQAFSYFRDKNY**KGQG*N RENLKSCSGFFVMFSLKTQRLMFNIPNQ*NGENT MSLFFKI*FFLVLYKVSLYVKAIVISKHSIHTF NLTKYLYTFSFRRQGFFGSLSNGILVLLHYAYL LPL*YHLGPGLIVLQMLVMPFSIYFSRTFSHDLW LIGLNRLKLHSRKKMQKASW*CLLQLGCYTISK MMQ*EFLLLYFLTSLLKVAFISIE*FSSFFNTG NQFVLMEEKFLCQQP*SESYRSNESIAFISVCPR EGSEKTFTCFQGDPCRFT*LES*RTGPTV*KMA FILLNTYKRMFYRWEDMTLERREFSEDLPGCQG LCLQAQCGSVASGPPPPCLRAAWRPTVLGVVKIF *GQTNLRDFKKCLSASYDFRRFCYM*SQLLFS* E*QRIRKSPP*IM*PAFLTSLTQAM*EIIILFS *FISVGACLSIKTTY*GKISNRLPLSPVRVLCCF *LRCHKNKDTCNL***SLIPILCFKVYKIIFLI LYLSLVS*QSMR*GGSFITILQSGKRRFLLGT* LSPLYNKTSKLGAVNWFAEGLAVRARIQTQV*VT SNCTVLPIITHMLSLIFLIY*EFIHL*TW*FTF IRFWSLKALVTSE*NLRDEM*NAAILESSFFCN IHQHFIEK*RFLWLSLPSRGLALVTEKDKETNDR I**LLLALGITESQLVTASPLLLKEEELAVPLS ELRLEMVIGASIRKA*GKA*SVG*NEAGEWGGG LGNIQNLAGDLELHEM*EWRGSSSQRSGTNEQLG SAHGRQ*KNPGKQNGQSRKGPKATFLRCGGG*G SHAK*GQMQLSSS*RALTSQLS*SFGWEPVMAQ WSEGRAVSGTQNLTPTTCFPPEEPPIPSKPLAKV C*QREPASMLASRDHACLYPLS*SCSSTVRWQK GGSRRGEKKGVCENKMLKNLHQINPSFLPFSF

Frame 1

TTGAHAHWCLAAWRAPSEAHARGHARASRSKVR ASASEAVGVGEFVKRDSRQLFPVREGNQCLAFS PSFYLP*SSACQLKYKPNCVLVWP*APWANVLRN LPSTVLMLKQNVWLSG*IWKPSKFK**TMDLGW GVMM*RKWEIVISPVNATRYRTWRIQGFMVSEE RPWQILLTWPVLWKFRPRKTGQ*KLL*NCFRVEK P*KLVKLM*LEQALGLL*QCITYFTSFL*GGNA WTLDWSLRRLGRE*KLSHSCTLPFLSL*EMMFL VPWFFSSLKPKTYVPDFVKFMDWESPKS*EK*VL NIKSLSLVAISALKHITTRICSFCL*TKD*F*G QSYINSLTFY*GKKVLYASQRMVPPVGK*IQVF GTGLPQNSMAYM*LMCSANSVSMMCAWSQPKL*L NFRTGTLSCFAFRKE*KCF*SKKNYLWNYQVRI LRNLVKIMVLVYLMLLFRSV*LPMRGAISRKHV IIF*IPMRCLICSQKL*KEKLLQKT*THRVLGIQ KLPEKIQMMHFCTFMNQVVQAIAK*QSHLYKTK TALAQNQRC*NKRQL*HQKLEKMRNIKNLSWNI AL*KIRVEPV*KCF*ALFRHHVTLRRVGRI*KYG KKVLLLMAWLPTS*KIIEFRINQRDLKMLLKWD ASLCLLQQHYGEYIVLRQRKRKKKNLAIVEEEM FLVMGELNYVPLAL*LM*YKMKKLNQLKQNIHLK IMLDLVPHVPKKHLEIEHVIQLKLQTSKI*PAL *VKNLVNCPTKKIAERI*VMG*RMNLQQLIQCF LLFRKVAKNHKQIAYYLIHPPLSPGIDTFPMIVG KQIN*LVSPNQSSVRS*A*VHS*DL*RSLRGNM GRLKILWIQK*RKVMESLPISVFKLNLTFC*RT RTA*RTLMFVKSLLWSIVIQIVVVNQQATSLTQR SFHSPRMKIV*NNRCLV*EKVL*P*RSYLSLIE NLWTLRSHLNH*PLNYPD*RVPKEKLKQWG**V VLMNFQIQIPVGKTASCAVC*HKIFVCYLTTSMK KQRMVSSQHQILPHRIIPLIKIVKHILTAIQQR TV*YQKLLWYCPIIILKLPVKIQMFLSEPQNNR *EVLTLPVEC**IR*KMPQVTKMEFVFRVRNLKQ ELVLKLKSQTRVVQIGSGISM*PWEEWFMSTK* LDSAHSLPQLRTFRLLVLKT*QLWLWMLYLRMG LSTGVNLLEATLFFLSFRELEQRGL**DRITEIL WMILLVANRFSLCSQNGTIQYLPVIQRLLLM*A VARLRA*QLKFTTSCIPIVSPKE*FIQCRFSSK *ITSLLPV**ALRLKRMARQVGTCSCWWISTLPM SVYVWSSLSLIPTRSNRHKALVGKNYCLLL*FL R*R*Q*QRNKGDSYGVTTKIWKIWALNLYFQTL VILWSLWEKYHYVLWKEKPMNFGEEDLL*PRVLW RNLSENNWSYSRPPEASKGHCH*LSRRCWHPKP AMGPLSLMMA*AYRKVAALLKLCPHASCHSSVL TGDLLCCR*LT*TTWNRKNRLNPTSLNFAKWPRP GVSLEKQSVIQGRACSNPCLPVSHHENRITGLK GTKGCSLYASEQRAAAAGTSTALTESAQCP*AA *TAGLSVSVFLEQMIPLVE*PDEIQA*RQFIHLH PWAQKVAI*YLPFATYLMIKFNDSLIGCLVCYL KGVIFVFVQFFFKLHICVYLIQLMLKSKG*SAF PGCPQGFCTGPLFSLQSSSLPYAAASCATSQT*R VSLLQ*KHSLGSFIRPLVILGIKTIDKKDKDRT EKI*SPVPGFLLCFL*KLRD*CSISQTSKMVKI L*ACFLKYDFFWYFIKYLFM*KQLSYQNTAYIRS T*PNIFTLFLSGDKGSLGPFQTVSWCYYIMPIY CPYNITWDQD*SFCKCLLCHSQSIFPAPFHMIC G**DSTD*NCIVEKKCKKPAGNVYCNWGAIQLVR *CNENFYFCIS*PACSKWLLYQLNDFPHFLIQE TNSCSWKKSSFASSLEVNLTGAMKVLHSLASAP EKVQRKPSLVFKGILVDLRNWNPEEQALLSKKWL LFF*IHINGCFIDGKT*P*KGESFQRICQAVRG SASRPSVAVWPQGLRLPA*GLHGGQLSWEL*KS FKARPI*GILKSVSVPLMISEGFAICNPNYCFLE SSRGLEKVLHKLCNRPS*LA*LKQCKR*LFCFH NL*VWGHASA*KQPIREKYLIDYLYRLLGFYVV FNSDAIRTKIHVIYNSNH*YLYCALRFTK*FFSY FILV*FLDSP*GKVVALSPFYKVGNEGSS*EPS CHLCIIKLRSSELLTGLLKA*L*EPEFRPRSE* LQTAQSFPLLPICYPLYF*FIRNSFIYKLGDSPL LDSGR*RL**LQSKT*EMRCKMQPFLRVPFSVT FINTSLRSEGSYGCLYLQEA*L*SLRKTRKLMI EYSSFFWR*VSQSHS*LQLALYY*KKRS*QSHYQ N*D*RW**ELVSEKLKAKHKV*ARMKLENGEGA WVTSRTWLGTWNYMRCKNGEVLAVRGQVQMNSW DLRMADSEKTQASKMVRAERGPRPRS*DVEGAEE ATPSKDRCSSAVPSEP*QASSAEASGGSQSWHS GVKEEQFQAPKT*PPRPVFHLKSHPFHPNPWQK SANRENRPVCWPVAIMPVFTL*AEAAHQR*DGKK VGPEEGKRRESVKTKC*RICIK*TLPSFLFP

Frame 2

QLVRMRTGVSRPGAPPPKRMLVGTHEPQDPRCA RRRPRRLVSENLLSGTPGNYFQSEKETSAWHSH HLSTYHDQVLVS*STSQIAFWFGHKLLGPMC*G TCPQQY*C*SKMCGCQGEYGNLPSSSDRQWIWDG E**CRESGKSLFHQ*MPLGTGLGESKVLWFPRR GLGKYC*HGQCCGNFVQEKQDNENFCETVSEWK SPESL*S*CD*SKRWDYCNSV*PILPASCKEEMH GP*TGV*EG*AENRSSLTHAPFHFFLFEK*CFW FHGSSAP*NQRRMFPILSNLWIGKVPKAKRNKF *I*RV*A*WLYQL*STLQQEYAVFVCEQKTSFKD KAT*TH*LFIKERKYYMQAKEWSHQ*ANEFKSS APVYPRTLWHICN*CAVPIL*V*CVHGASQNSD *ISELGHSLVLHSGRSENVFKARKIICGIIR*GY *GI**R*WF*FI*CYSSEACDFR*EEQFPGSM* *YFRFL*DV*FAVKSCEKKNYCRKRKHTEF*GF RSYQKKYK*CIFVHL*IRWSRP*QNDRAIFTKQR QLLLRIKDVRTRDNCSIRSWRK*ET*KIFPGT* LFRKSVWNQFRNVFKPFSDTMSL*GEWAGSRNM ERKYYC*WHGCQHLEK**NSESTKEI*RCY*SGM PASAFCNNIMGST*CSDREREKKRI*QLWKKKC F*LWAS*IMFHWLYNSCSTK*KN*IN*NRTFI* KLC*TWSHTCPRNIWK*NTSFS*NSRHQRFSQHF K*RIWSIAQQKKLQNEYKLWARE*TYSNLYNVF CFSGR*QKITNRLHII*YIPLFPLV*TRFQ*** ENR*INWFLQTNRP*EAKLEFTARIFREV*EAIW EG*KSSGYRSRGK*WSHYQSQSSS*T*HSAEGQ EPLREL*CL*NHYYGA**FR**LSTSKPHP*LR EVSILQG*RLFRTTDA*FERKSYDPEGVISL**K TFGP*EVI*ITSL*IIQTEGFRKRNSNNGDDES F**TSKFRFQ*ERQQVVQCVNTRFLYVI*QQA* KNREWCHPNIRFCHTG*FL**K**NTF*QQYNRE LCDIRNSFGIAL**F*SYR*RFRCSYQSLRTTD RKS*LSQWNVNESGRRCHR*PKWNLFSE*GI*S KSLF*N*RVKHVLFRLAAAFRCSPGKNGLCQQND WTQHIHCPN*GHSGCLY*RPDNCGCGCCT*EWV SVQVSTF*KRPCSSFPSESSSREDCDETG*QRY CG*YC**RIASVFVLRMGQSSICPLSRGCC*CKQ WPG*ELSS*NSQHLVSLSFHQRNDSFNAGSPAS R*QVYCLFDEH*D*REWRGRWEPARAGGSARCP *AYTSGAAYH*FLREATGTRLWSEKITVFYSNSS ARDNSDRGTKETLMVLPQKSGRSGP*ICISRH* *FSGPCGKSTTMFCGKRSQ*TSERKIYCDQEYC GGIYPRTTGATPDHRRHPRDIATDCPEGVGIPSL PWGH*V**WPELTGKLPPY*SSVLMPAAIPVCS RETFYAAVS*HRPLGTGKTD*TQPH*TSQNGPG LASLWKSRV*YKAEPAAIHASL*ATMRTESLV*K EQRDVHCMPLSREQQQQVPARP*LNQPSVPEQL RQQGSLYQSFLSR*FP*LSSQMKFKPKDNSFIC IHGHRRLLYSIYLLLLI***NLMTV*LVAWFVI* RV*FLFLYSFFSSFTFACI*FS*CSSPRGSLPS QAAPRVSALVPSFPFSLLHFPMLLLHVLHLRLK EFLYYSENIL*GLSSGL*LF*G*KLLIKRTRIEQ RKFKVLFRVFCYVFFKNSETDVQYPKPVKW*KY YELVF*NMIFFGTL*SISLCESNCHIKTQHTYV QPNQISLHFFFQETRVLWVPFKRYLGVITLCLSI ALIISLGTRTDRSANACYAILNLFFPHLFT*FV VNRTQQTKIA**KKNAKSQLVMFIATGVLYN** DDAMRISTFVFPDQPAQSGFYIN*MIFLIF*YRK PIRAHGRKVPLPAALK*ILQEQ*KYCIH*RLPQ RRFRENLHLFSRGSL*IYVIGILKNRPYCLKNG FYSSKYI*TDVL*MGRHDLRKERVFRGFARLSGA LPPGPVWQCGLRASASLLEGCMEANCPGSCKNL LRPDQFEGF*KVSQCLL*FQKVLLYVIPTTVFL RVAED*KKSSINYVTGLPD*PDSSNVRDNYSVFI IYKCGGMPQHKNNLLGKNI**ITFIAC*GFMLF LTQMP*EQRYM*FIIVIINTYIVL*GLQNNFSH TLS*FSFLTVHEVRW*LYHHFTKWETKVPLRNLV VTFV**NFEARSC*LVC*RLSCKSQNSDPGLSD FKLHSPSHYYPYAIPYIFNLLGIHSFINLVIHL Y*ILVAEGFSNFRVKLER*DVKCSHS*EFLFL*H SSTLH*EVKVPMAVSTFKRLSFSH*ERQGN*** NIVASSGVRYHRVTASYS*PFIIERRGASSPTI RIKTRDGNRS*YQKSLRQSIKCRLE*SWRMGRGL G*HPEPGWGPGTT*DVRMERF*QSEVRYK*TAG ICAWQTVKKPRQAKWSEQKGAQGHVLEMWRGLR KPRQVRTDAAQQFLASPDKPAQLKLRVGASHGTV E*RKSSFRHPKPDPHDLFST*RATHSIQTLGKS LLTERTGQYAGQSRSCLSLPSKLKLLINGEMAK RWVQKRGKEGSL*KQNAEESASNKPFLPSFFL