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Sequences

Sequence NM_199462

GCCGCAAAGACAGAGCGGGCAGAGGCGATGGAGGGCGACGGGGTGCCATGGGGCAGCGAGCCCGTCTCGGGTCCCGGCCCCGGCGGCGGCGGAATGATCC GCGAGCTGTGCCGGGGCTTCGGCCGCTACCGCCGCTACCTGGGACGGCTGCGACAGAACCTGCGCGAGACCCAGAAGTTCTTCCGCGACATCAAGTGCTC CCACAACCACACTTGTCTCTCCTCCCTCACGGGCGGCGGCGGGGCCGAGCGCGGCCCTGCAGGCGATGTCGCCGAAACCGGGCTGCAGGCGGGCCAACTG AGCTGCATTTCCTTCCCACCTAAGGAAGAGAAGTACCTCCAGCAGATTGTGGACTGCCTCCCTTGCATACTGATCCTCGGCCAGGATTGTAACGTCAAGT GCCAGCTGTTGAATCTGCTGTTGGGGGTGCAGGTGCTTCCCACCACCAAGCTGGGCAGTGAGGAGAGCTGTAAGCTTCGGCGCCTCCGCTTCACCTATGG GACTCAGACTCGGGTCAGCCTGGCGCTCCCTGGACAGTATGAACTAGTGCACACGCTGGTTGCTCATCAGGGCAACTGGGAGACCATCCCTGAGGAGGAT CTGGAGGTCCAAGAGAACAATGAGGATGCTGCTCATGTTTTAGCGGAACTGGAGGTAACGATGCACCATGCTCTCTTACAGGAAGTGGACGTTGTGGTAG CACCATGCCAAGGCCTCCGGCCCACAGTGGATGTTCTGGGTGACTTGGTGAATGATTTCTTGCCTGTGATAACCTATGCACTCCACAAAGATGAACTCTC TGAGAGGGATGAGCAAGAGCTTCAGGAAATCCGAAAGTATTTCTCCTTTCCTGTATTCTTTTTCAAAGTGCCGAAACTGGGCTCGGAGATAATAGACTCC TCAACCAGGAGAATGGAGAGCGAAAGATCACCGCTTTATCGCCAGCTAATTGACCTGGGCTATCTGAGCAGCAGTCACTGGAACTGTGGGGCTCCTGGCC AGGATACTAAAGCTCAGAGCATGTTGGTGGAACAGAGTGAAAAGCTGAGACACTTGAGCACATTTTCTCACCAGGTGTTACAGACTCGCCTGGTGGATGC AGCCAAGGCCCTGAACCTGGTGCACTGCCACTGCCTTGACATCTTTATTAACCAGGCATTTGACATGCAGCGGGACCTGCAGATCACTCCCAAACGTCTG GAATATACTCGAAAAAAGGAGAATGAGTTGTATGAATCATTGATGAATATTGCCAACCGAAAGCAGGAGGAAATGAAGGATATGATTGTTGAGACACTTA ATACCATGAAGGAGGAACTTCTGGATGATGCTACTAACATGGAGTTTAAAGACGTCATTGTCCCTGAGAATGGAGAACCAGTAGGCACCAGAGAGATCAA ATGCTGCATCCGACAGATCCAGGAACTCATCATCTCCCGACTTAATCAGGCAGTGGCTAATAAGCTGATCAGCTCAGTGGATTACCTGAGGGAAAGCTTC GTCGGAACCCTGGAACGATGTCTGCAGAGCCTGGAGAAGTCTCAGGATGTCTCAGTTCACATCACCAGTAATTATCTCAAACAGATCTTAAATGCTGCCT ATCATGTTGAAGTCACGTTTCACTCAGGGTCGTCAGTTACAAGGATGCTATGGGAGCAAATCAAACAGATCATCCAGCGCATCACATGGGTGAGCCCACC TGCCATCACTCTGGAATGGAAGAGGAAGGTGGCCCAGGAAGCCATTGAGAGCCTCAGCGCCTCCAAATTGGCTAAGAGCATTTGCAGCCAATTCCGGACT CGGCTCAATAGTTCCCACGAGGCTTTTGCAGCCTCCTTGCGGCAGCTGGAAGCTGGCCACTCAGGCCGGTTAGAGAAAACGGAAGATCTATGGCTGAGGG TTCGGAAAGATCATGCTCCCCGCCTGGCCCGCCTTTCTCTGGAAAGCTGTTCTTTACAGGATGTCTTGCTTCATCGTAAACCTAAACTGGGACAGGAACT GGGCCGGGGCCAGTATGGTGTGGTATACCTGTGTGACAACTGGGGAGGACACTTCCCTTGTGCCCTCAAATCAGTTGTCCCTCCAGATGAGAAGCACTGG AATGATCTGGCTTTGGAATTTCACTATATGAGGTCTCTGCCGAAGCATGAGCGATTGGTGGATCTCCATGGTTCAGTCATTGACTACAACTATGGTGGTG GCTCCAGCATTGCTGTGCTCCTCATTATGGAGCGGCTACACCGGGATCTCTACACAGGGCTGAAGGCTGGGCTGACCCTGGAGACACGTTTGCAGATAGC ACTAGATGTGGTGGAGGGAATCCGCTTCCTGCACAGCCAGGGACTTGTCCATCGTGATATCAAACTGAAAAATGTGCTGCTGGATAAGCAGAACCGTGCC AAGATCACTGACTTAGGATTCTGCAAGCCAGAGGCCATGATGTCAGGCAGCATTGTGGGGACACCAATCCATATGGCCCCTGAACTTTTCACAGGGGCTC GCCCAGAACGTCTTCCTGTGTTTGATGAGGAGTGCTGGCAGTTGATGGAAGCCTGTTGGGATGGCGACCCCTTGAAGAGGCCTCTCTTGGGCATTGTCCA GCCCATGCTCCAGGGCATCATGAATCGGCTCTGCAAGTCCAATTCTGAGCAGCCAAACAGAGGACTAGATGATTCTACTTGAAAGCAAAGACCTTTCTCT TTCACTCTCTAGTTATTTCCTTCCCCCTCACCTTTTGGCCATGGGGAGAATTTGACATTTATTCACTATAGGACACACTCCCAAGGGAACTGGTGCTTGC TGGGAAACTTGGAACCTTCCCAGGCAGGGATGACTCCTGGACAGTGAAGAGTTGAATGACTGAGCATATTCAGCAGCTCACTGAAGCGCCAAGCTATCCC TTTAGCAAAAAAGTGTCTCAGATGTGTAAAAGCTGAGGAATGTGGTGTTCTGGCTTCACAAATGAAAAGGAGGCAGATGTTACCATTGTCTTTTCACTGT ATATACTTCTAAGACAGCAAGCGGGACACTGCAGTGGCAATAGTGTTAAAAAATCTCATTCTCATGATTTTTGGCTCTAGCTAGGAATAGTTTAGTCAGG ACTCAGAAAATTTGAGCTTAGTTCTGGGATTATGAAAACATGGGGACAAAAACAATAACTTGTGGATGTCTGGTTCCTGCTGTCTGCAGCCAGGTATCTC AGGTTGCAATGGTCAGAAGTCCCAGTGAGGGAGCTAGAAACAGAGCTATCTGTTCCTCATAGTGCCAGTGTGTTTACATTTATAGGACCACATATCCCTG GTTTCTGGGGGAGGGTTTCACTGTTACATCACCAAGAGGCCCTGAAAAGAGGAAAAAAAAAAAAAAAGAGGCCAGGCATGGTGGCTCACGCCTGTAATCT CAGCACTTTGGGAGGCTGAGGCGGGCGGATCACAAGGTCCAGAGTTCAAGAGCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAGATACAAAAA ATTAGCCGGGCGTGGTGGTGCATGCCTGTAATCCAAGATACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCCG AGATCATGCCATTGCACTCCAGCCTGGGCGACAGAGTGAGACTCTGTCTCAAAAAAAAAAAAAAAATAGAATGTGTATGCATATATTTGTGTGTATATGT ATATATGTGTGTGTGTCTATATCTCTATCTATATAGACATACACACAGGAGTTATTGGATTTAGAGTTACTGCTAACCCCAGAACAGAATCTGTTCTTTT ACCTTTGAGTCTTTTCTTTTGTTTACCTCTTTTCATCTCAAAGTGGGAAAGCTCCAGATAACATGGTACTTAGGAGTGAGTGTCTAAGCAAAACCAACCC AATGCGAAGTATTTGGGTGAGAACTGAGAGGTGGGAGATGATTGGAGGCCATGGCCTATGTACAAACATACTGGAAGAAAACCAGCTTGTTTTTAAAACT TAACACAATCAGAAATTTTTCTTTTTGTGTTTGAATCTAACACACTGACGTTTGGAAAACTTGATCAATGAGCTTTTAACCACGATTTCTCCCGCAATTT GTTCCTTCTTTTTACCTTTTTAAAAATCTGTTAGAAGAAAAAAAGCAGCAGACGAAAGAGAAAAACCCTCCTCTGGTAGTTCTGTGTGTGCCCCTCACCC CTGTGTGCTAGTGTCTGGGAAGTTTCCCTGAAAGGTGGGAGGCGGGTGGGTGGTCTTTTGGAGGGTTCCTCATGAAGTGTGCTTGAGGAAAGAAATTCTG ATTCTAGGCAGAGGAAGGGGAACAATTTAAATATTGGTGCATCTCAGATGCACTTGACTTCAAGCCTTCCTCAACCAAACTGGTCCATTAGATTCCGAAA AACAGGTAGACGAGGAAGTAGACAGTGGAAGTGAGTAGTCTCCCTCCATCTGCCTAATCCCCAATAACTGTGGTCTGGCCCCTGTGTTCAGCCCGAGAGT TTGTAAAACAGGTCCCCAGGTAGGTGTATAAGATGAGTTGCAAATTAGCCGGGCATGCTGGCACGCACCAGTAATCCCAGCTACTTGGGAGGCTGAGGCA GGAGAATCACTTGAACCCGGGAGGCAGAGGTCATGGTGAGCCGAGATCACGCCACTGCACTCCAGCCTGGGCAACAGAGCGAGACTCTATCTCAAAAAAA AACAAAAAAAAAAACAAAAAACAAAGATGAGTCGCACATCTGCTGCTGGGATTTTCTAGGGTTGTCTATGACAGAATGACCATCTTTTAAATATTAATGG AGTATAAATGGAGTCTATAATGGGTCTTTCATATAACTTTTAACTCTTTGGCTATCCTGGGCTCTGATCATGATATGTTTGAGCATAGTAGCTCCCTAAA CTCTTGGAGCCTTTCAGAAATTCCATGTAGTGCTAATAACCTTTTTACTTGCAAATGATAAAGTAACTGACTCAGTGTCTTTGGGCTCTGCAGGCTTTAG CCTTGTTTTGGTAGGATGTTCAGTATATTCTCAGAATTTTTACCACCTATTTAGCTATACTTCAAGTACTCTATTCTCTGCACTAACTTACTGTCCTTCT GGGAACTATGATGGGGCTTCAAGGGAGTCAGGTGTCAAGAAAGGAGGGGTAAGTACTCTCTACTTGCTGGAAAATCATTGTAAGTCTGTTGTGTATGAAA TTTTAGGAAAAGTCTTATATAGTTCCCTTTCCAGACTGTTTTCTTTTGACTCTAACTATAATCATAAGTCTGTGCTTCCATTATGAAGGTCACATTCCTA GCATTCTTGGGAAGTATTAGCTCATACTCTCATTCACATATGGGAGGTTAGATTTTTTTCCTCTACCCAGAGTCCCTTTTTAGTTTACCCCACGGCTTAG TTTGCTGTCAGATACCAGTTCTCTAGCAGATTCCCCAACAGTTTTTTCCCCAGTGGGGAGGGTGGAAGGGAGGGACTGATATAAGTAAGGAGATGAGTAG TTGTGTTACAGTTCATTTTCTTTAAAAAAAAGTATTTTGAGAAAAGGTGCAAAATATTCTTGAAAGTCTCTAGGCCAGCCAAAGTCCACATATGGATATT TGGGGATGTTATTTAAATACTCAGCAGGCTGAGTGCAGGTATACGTGTGTATAGAGTGTGTATACTTTGCTTTTGTTTTATAACATTGTCAGCTAATTTT GGCTTTGTTCTTTGGCATCCATTCTTATTATAAGTGATGGAATGCCATGAAATGTACTGTATTGTATATTACTTGGGAGGACACTAGGTTTTCAAAGAAG TCTGGCAGCACTTGGGTTATAGAGGGCTCAGCATGACCAAAGTCCTAAAGATTTTACCTCCCAGCTTTGGTTGTATGTGTTCCCAAGTGGTGAGGTGAGA TTGTGGCTGGAGGAAGAAAAAGGATGGCATGAAAGAATGACCCTTATTGTGGTCTGTCCTTCTAATCAACATAATTAGGGCAGCTTACCCCAACATGAAA ATGATGACCTGGCCATTTTTAATGGCCAGAGCTTGAAGTCTGGTCTCTCATTTTGTTTCAGAAATGAGTGAGAGGCCTTCCTGCAGAGCAGTCAGGAGAA ATGGTGGAGCCTGGGGCCCTGGAATGGCTGACCCTGTGCCTAGAGAGCTGATGGCAAGGGCTGTCTGGCATGGCTCATTTGGGTGGGGTTTCCCCAGGCA TACCTTAGTTCCCTGATCCTCTGCAAAGAGTAGCTCATTGACTGAGCAAGCGCTTCAGGAGGACTGTGCTGGTTGTTCCCAGACCAAAGAGAGTCACTTT TGACTCCATCAACTTCAAGGGGACAGAGCCTAGGCAGCAGATTCTCCTAATTTTTAACACTAAAATTCAAGGAAGCAGTGGAGGAAAGAATGCATTACTA CCACAGATAGAAATAGGGGACTCATAGAACTCTCGACTAGTACCTGTCAGCTCTCAAATGCATTCTTGTGTCTTTGCTTGAGCTGCCAAAGAAGGGTCAC AAAGTGTTCTTCCTCATGGAAGAAGTGCCTCGGGGTTGCAGGGCTGCAAAGTGACAACTGCACTGAATGACACTTTATTTTTTGGCTTTGGCTTATTATT TAGCACTGGGAGGCCCAGGGGAATTGGTGATTACAGTAGCACTTTGGGAAGTTAAAGCCCCCTTTGGGCTTGCTTTGGAGAGATGATGGCATGCTTGGTA TTCCATTTGGATAATCAGGAAGCCTCCCTAGTCCATCCATATTGTGTCAGAGTGGGATTAACAACCCTGGAAGAGTCCACTGCCAAAAGAGTAGTTGCTT TCCTGGAATTTCCAAAGCTTTTGGATTTTCTGGATCAAGTAACCCACTTTTTAAAACCTGAGGTCAGGAGTTCGAGACCAGCCTGGTAACATGGTGAAAC CCCGTCTCTATTAAAAATAGAAAAAATTAGCCAGGCATGGTGGCGGGCACCTATAGTCCCAGCTACTCAGGAGGCTGAGGTAGGAGAATTGCTTGAACCC AGGAGACAGAGGCTGCATTGAGCCAAGATCACACCACTGCACTCCAGCCTGGGCAGCAGAGCAAGACTCCATCTCAAAAAAAAAAAAAAGAAAAAGAAAA AGAAGGTTAATCCTTCAGTTATGGAGGTGGGATGAATAGAGCTTGTTTGATGTTAAAGTGGGTAAGGAGGGAGTGGCCTTGAGACACTTGTATTCCAAAC TCTCCTGGAGGTTTCCAGTAGCACTACTGTTCCTAAAAGGGTTTCATTTTTAACTTCATCTGTTTTGTTAACATCCAGTCCAATTGAGGTGATCTCAGAG GTGCATCAGGACATCTAGCACTGGGGAGGCCACCTTGCCCAGATAGTTGAAAAGAAAATTGGTCTGGGCAGCCTGTTGTCTTTTGTCTTCATGTAATGTT TTTTCTTTGTTTTAAAGGACTAATGTTTATTACAGTGTTAAATAAAAGTGTAAGATACTAAGTGTGTAGAATAAAAGTGCAATAACAAAAGACAATGACT TTGGCACACACTTCAGTCTTTATCCTCTCTCCTTTCTTGTGCTACCTGGCTCTTTCCATAATATTGTTACAGCAGGACCGTCTTAATTGTGTGCATTTTG AAGAGATGCGACTCTGGGTTAATCTTCATTAGTGTAATATTGAAGGGTTGGGTTTGGTTTTATAGAGTATTCTGTATACTTGTTGGGATACACAAATACC AGATGTGCTGTATAATAAAGATCACATTAACGTTT

refseq_RIPK5.F1 (forward primer)
refseq_RIPK5.R1 (reverse primer)
Single exon skipping

Frame 0

AAKTERAEAMEGDGVPWGSEPVSGPGPGGGGMI RELCRGFGRYRRYLGRLRQNLRETQKFFRDIKCS HNHTCLSSLTGGGGAERGPAGDVAETGLQAGQL SCISFPPKEEKYLQQIVDCLPCILILGQDCNVK CQLLNLLLGVQVLPTTKLGSEESCKLRRLRFTYG TQTRVSLALPGQYELVHTLVAHQGNWETIPEED LEVQENNEDAAHVLAELEVTMHHALLQEVDVVV APCQGLRPTVDVLGDLVNDFLPVITYALHKDELS ERDEQELQEIRKYFSFPVFFFKVPKLGSEIIDS STRRMESERSPLYRQLIDLGYLSSSHWNCGAPG QDTKAQSMLVEQSEKLRHLSTFSHQVLQTRLVDA AKALNLVHCHCLDIFINQAFDMQRDLQITPKRL EYTRKKENELYESLMNIANRKQEEMKDMIVETL NTMKEELLDDATNMEFKDVIVPENGEPVGTREIK CCIRQIQELIISRLNQAVANKLISSVDYLRESF VGTLERCLQSLEKSQDVSVHITSNYLKQILNAA YHVEVTFHSGSSVTRMLWEQIKQIIQRITWVSPP AITLEWKRKVAQEAIESLSASKLAKSICSQFRT RLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLR VRKDHAPRLARLSLESCSLQDVLLHRKPKLGQEL GRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHW NDLALEFHYMRSLPKHERLVDLHGSVIDYNYGG GSSIAVLLIMERLHRDLYTGLKAGLTLETRLQIA LDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRA KITDLGFCKPEAMMSGSIVGTPIHMAPELFTGA RPERLPVFDEECWQLMEACWDGDPLKRPLLGIVQ PMLQGIMNRLCKSNSEQPNRGLDDST*KQRPFS FTL*LFPSPSPFGHGENLTFIHYRTHSQGNWCL LGNLEPSQAGMTPGQ*RVE*LSIFSSSLKRQAIP LAKKCLRCVKAEECGVLASQMKRRQMLPLSFHC IYF*DSKRDTAVAIVLKNLILMIFGSS*E*FSQ DSENLSLVLGL*KHGDKNNNLWMSGSCCLQPGIS GCNGQKSQ*GS*KQSYLFLIVPVCLHL*DHISL VSGGGFHCYITKRP*KEEKKKKRGQAWWLTPVI SALWEAEAGGSQGPEFKSSLANMVKPRLY*RYKK LAGRGGACL*SKILRRLRQENRLNLGGGGCSEP RSCHCTPAWATE*DSVSKKKKK*NVYAYICVYM YICVCVYISIYIDIHTGVIGFRVTANPRTESVLL PLSLFFCLPLFISKWESSR*HGT*E*VSKQNQP NAKYLGEN*EVGDDWRPWPMYKHTGRKPACF*N LTQSEIFLFVFESNTLTFGKLDQ*AFNHDFSRNL FLLFTFLKIC*KKKSSRRKRKTLLW*FCVCPSP LCASVWEVSLKGGRRVGGLLEGSS*SVLEERNS DSRQRKGNNLNIGASQMHLTSSLPQPNWSIRFRK TGRRGSRQWK*VVSLHLPNPQ*LWSGPCVQPES L*NRSPGRCIR*VAN*PGMLARTSNPSYLGG*G RRIT*TREAEVMVSRDHATALQPGQQSETLSQKK TKKKTKNKDESHICCWDFLGLSMTE*PSFKY*W SINGVYNGSFI*LLTLWLSWALIMICLSIVAP* TLGAFQKFHVVLITFLLANDKVTDSVSLGSAGFS LVLVGCSVYSQNFYHLFSYTSSTLFSALTYCPS GNYDGASRESGVKKGGVSTLYLLENHCKSVVYE ILGKVLYSSLSRLFSFDSNYNHKSVLPL*RSHS* HSWEVLAHTLIHIWEVRFFSSTQSPFLVYPTA* FAVRYQFSSRFPNSFFPSGEGGREGLI*VRR*V VVLQFIFFKKKYFEKRCKIFLKVSRPAKVHIWIF GDVI*ILSRLSAGIRVYRVCILCFCFITLSANF GFVLWHPFLL*VMECHEMYCIVYYLGGH*VFKE VWQHLGYRGLSMTKVLKILPPSFGCMCSQVVR*D CGWRKKKDGMKE*PLLWSVLLINIIRAAYPNMK MMTWPFLMARA*SLVSHFVSEMSERPSCRAVRR NGGAWGPGMADPVPRELMARAVWHGSFGWGFPRH TLVP*SSAKSSSLTEQALQEDCAGCSQTKESHF *LHQLQGDRA*AADSPNF*H*NSRKQWRKECIT TTDRNRGLIELSTSTCQLSNAFLCLCLSCQRRVT KCSSSWKKCLGVAGLQSDNCTE*HFIFWLWLII *HWEAQGNW*LQ*HFGKLKPPLGLLWRDDGMLG IPFG*SGSLPSPSILCQSGINNPGRVHCQKSSCF PGISKAFGFSGSSNPLFKT*GQEFETSLVTW*N PVSIKNRKN*PGMVAGTYSPSYSGG*GRRIA*T QETEAALSQDHTTALQPGQQSKTPSQKKKKEKEK EG*SFSYGGGMNRACLMLKWVRREWP*DTCIPN SPGGFQ*HYCS*KGFIFNFICFVNIQSN*GDLR GASGHLALGRPPCPDS*KENWSGQPVVFCLHVMF FLCFKGLMFITVLNKSVRY*VCRIKVQ*QKTMT LAHTSVFILSPFLCYLALSIILLQQDRLNCVHF EEMRLWVNLH*CNIEGLGLVL*SILYTCWDTQIP DVLYNKDHINV

Frame 1

PQRQSGQRRWRATGCHGAASPSRVPAPAAAE*S ASCAGASAATAATWDGCDRTCARPRSSSATSSA PTTTLVSPPSRAAAGPSAALQAMSPKPGCRRAN* AAFPSHLRKRSTSSRLWTASLAY*SSARIVTSS ASC*ICCWGCRCFPPPSWAVRRAVSFGASASPM GLRLGSAWRSLDSMN*CTRWLLIRATGRPSLRRI WRSKRTMRMLLMF*RNWR*RCTMLSYRKWTLW* HHAKASGPQWMFWVTW*MISCL**PMHSTKMNS LRGMSKSFRKSESISPFLYSFSKCRNWARR**TP QPGEWRAKDHRFIAS*LTWAI*AAVTGTVGLLA RILKLRACWWNRVKS*DT*AHFLTRCYRLAWWM QPRP*TWCTATALTSLLTRHLTCSGTCRSLPNVW NILEKRRMSCMNH**ILPTESRRK*RI*LLRHL IP*RRNFWMMLLTWSLKTSLSLRMENQ*APERS NAASDRSRNSSSPDLIRQWLIS*SAQWIT*GKAS SEPWNDVCRAWRSLRMSQFTSPVIISNRS*MLP IMLKSRFTQGRQLQGCYGSKSNRSSSASHG*AH LPSLWNGRGRWPRKPLRASAPPNWLRAFAANSGL GSIVPTRLLQPPCGSWKLATQAG*RKRKIYG*G FGKIMLPAWPAFLWKAVLYRMSCFIVNLNWDRN WAGASMVWYTCVTTGEDTSLVPSNQLSLQMRSTG MIWLWNFTI*GLCRSMSDWWISMVQSLTTTMVV APALLCSSLWSGYTGISTQG*RLG*PWRHVCR* H*MWWRESASCTARDLSIVISN*KMCCWISRTVP RSLT*DSASQRP*CQAALWGHQSIWPLNFSQGL AQNVFLCLMRSAGS*WKPVGMATP*RGLSWALS SPCSRAS*IGSASPILSSQTED*MILLESKDLSL SLSSYFLPPHLLAMGRI*HLFTIGHTPKGTGAC WETWNLPRQG*LLDSEELND*AYSAAH*SAKLS L*QKSVSDV*KLRNVVFWLHK*KGGRCYHCLFTV YTSKTASGTLQWQ*C*KISFS*FLALARNSLVR TQKI*A*FWDYENMGTKTITCGCLVPAVCSQVS QVAMVRSPSEGARNRAICSS*CQCVYIYRTTYPW FLGEGFTVTSPRGPEKRKKKKKEARHGGSRL*S QHFGRLRRADHKVQSSRAAWPTW*NPVSTKDTK N*PGVVVHACNPRYSGG*GRRIA*TWEAEVAVSR DHAIALQPGRQSETLSQKKKKNRMCMHIFVCIC IYVCVSISLSI*TYTQELLDLELLLTPEQNLFF YL*VFSFVYLFSSQSGKAPDNMVLRSECLSKTNP MRSIWVRTERWEMIGGHGLCTNILEENQLVFKT *HNQKFFFLCLNLTH*RLENLINELLTTISPAI CSFFLPF*KSVRRKKAADEREKPSSGSSVCAPHP CVLVSGKFP*KVGGGWVVFWRVPHEVCLRKEIL ILGRGRGTI*ILVHLRCT*LQAFLNQTGPLDSE KQVDEEVDSGSE*SPSICLIPNNCGLAPVFSPRV CKTGPQVGV*DELQISRACWHAPVIPATWEAEA GESLEPGRQRSW*AEITPLHSSLGNRARLYLKK KQKKKQKTKMSRTSAAGIF*GCL*QNDHLLNING V*MESIMGLSYNF*LFGYPGL*S*YV*A**LPK LLEPFRNSM*C**PFYLQMIK*LTQCLWALQAL ALFW*DVQYILRIFTTYLAILQVLYSLH*LTVLL GTMMGLQGSQVSRKEG*VLSTCWKIIVSLLCMK F*EKSYIVPFPDCFLLTLTIIISLCFHYEGHIP SILGKY*LILSFTYGRLDFFPLPRVPF*FTPRLS LLSDTSSLADSPTVFSPVGRVEGRD*YK*GDE* LCYSSFSLKKSILRKGAKYS*KSLGQPKSTYGY LGMLFKYSAG*VQVYVCIECVYFAFVL*HCQLIL ALFFGIHSYYK*WNAMKCTVLYITWEDTRFSKK SGSTWVIEGSA*PKS*RFYLPALVVCVPKW*GE IVAGGRKRMA*KNDPYCGLSF*ST*LGQLTPT*K **PGHF*WPELEVWSLILFQK*VRGLPAEQSGE MVEPGALEWLTLCLES*WQGLSGMAHLGGVSPG IP*FPDPLQRVAH*LSKRFRRTVLVVPRPKRVTF DSINFKGTEPRQQILLIFNTKIQGSSGGKNALL PQIEIGDS*NSRLVPVSSQMHSCVFA*AAKEGS QSVLPHGRSASGLQGCKVTTALNDTLFFGFGLLF STGRPRGIGDYSSTLGS*SPLWACFGEMMACLV FHLDNQEASLVHPYCVRVGLTTLEESTAKRVVA FLEFPKLLDFLDQVTHFLKPEVRSSRPAW*HGET PSLLKIEKISQAWWRAPIVPATQEAEVGELLEP RRQRLH*AKITPLHSSLGSRARLHLKKKKKKKK KKVNPSVMEVG*IELV*C*SG*GGSGLETLVFQT LLEVSSSTTVPKRVSFLTSSVLLTSSPIEVISE VHQDI*HWGGHLAQIVEKKIGLGSLLSFVFM*C FFFVLKD*CLLQC*IKV*DTKCVE*KCNNKRQ*L WHTLQSLSSLLSCATWLFP*YCYSRTVLIVCIL KRCDSGLIFISVILKGWVWFYRVFCILVGIHKY QMCCIIKITLTF

Frame 2

RKDRAGRGDGGRRGAMGQRARLGSRPRRRRNDP RAVPGLRPLPPLPGTAATEPARDPEVLPRHQVL PQPHLSLLPHGRRRGRARPCRRCRRNRAAGGPT ELHFLPT*GREVPPADCGLPPLHTDPRPGL*RQV PAVESAVGGAGASHHQAGQ*GEL*ASAPPLHLW DSDSGQPGAPWTV*TSAHAGCSSGQLGDHP*GG SGGPREQ*GCCSCFSGTGGNDAPCSLTGSGRCGS TMPRPPAHSGCSG*LGE*FLACDNLCTPQR*TL *EG*ARASGNPKVFLLSCILFQSAETGLGDNRL LNQENGERKITALSPAN*PGLSEQQSLELWGSWP GY*SSEHVGGTE*KAETLEHIFSPGVTDSPGGC SQGPEPGALPLP*HLY*PGI*HAAGPADHSQTS GIYSKKGE*VV*IIDEYCQPKAGGNEGYDC*DT* YHEGGTSG*CY*HGV*RRHCP*EWRTSRHQRDQ MLHPTDPGTHHLPT*SGSG**ADQLSGLPEGKL RRNPGTMSAEPGEVSGCLSSHHQ*LSQTDLKCCL SC*SHVSLRVVSYKDAMGANQTDHPAHHMGEPT CHHSGMEEEGGPGSH*EPQRLQIG*EHLQPIPD SAQ*FPRGFCSLLAAAGSWPLRPVRENGRSMAEG SERSCSPPGPPFSGKLFFTGCLASS*T*TGTGT GPGPVWCGIPV*QLGRTLPLCPQISCPSR*EAL E*SGFGISLYEVSAEA*AIGGSPWFSH*LQLWWW LQHCCAPHYGAATPGSLHRAEGWADPGDTFADS TRCGGGNPLPAQPGTCPS*YQTEKCAAG*AEPC QDH*LRILQARGHDVRQHCGDTNPYGP*TFHRGS PRTSSCV**GVLAVDGSLLGWRPLEEASLGHCP AHAPGHHESALQVQF*AAKQRTR*FYLKAKTFL FHSLVISFPLTFWPWGEFDIYSL*DTLPRELVLA GKLGTFPGRDDSWTVKS*MTEHIQQLTEAPSYP FSKKVSQMCKS*GMWCSGFTNEKEADVTIVFSL YILLRQQAGHCSGNSVKKSHSHDFWL*LGIV*SG LRKFELSSGIMKTWGQKQ*LVDVWFLLSAARYL RLQWSEVPVRELETELSVPHSASVFTFIGPHIP GFWGRVSLLHHQEALKRGKKKKKRPGMVAHACNL STLGG*GGRITRSRVQEQPGQHGETPSLLKIQK ISRAWWCMPVIQDTQEAEAGESLEPGRRRLQ*A EIMPLHSSLGDRVRLCLKKKKKIECVCIYLCVYV YMCVCLYLYLYRHTHRSYWI*SYC*PQNRICSF TFESFLLFTSFHLKVGKLQITWYLGVSV*AKPT QCEVFG*ELRGGR*LEAMAYVQTYWKKTSLFLKL NTIRNFSFCV*I*HTDVWKT*SMSF*PRFLPQF VPSFYLFKNLLEEKKQQTKEKNPPLVVLCVPLT PVC*CLGSFPERWEAGGWSFGGFLMKCA*GKKF* F*AEEGEQFKYWCISDALDFKPSSTKLVH*IPK NR*TRK*TVEVSSLPPSA*SPITVVWPLCSARE FVKQVPR*VYKMSCKLAGHAGTHQ*SQLLGRLRQ ENHLNPGGRGHGEPRSRHCTPAWATERDSISKK NKKKNKKQR*VAHLLLGFSRVVYDRMTIF*ILM EYKWSL*WVFHITFNSLAILGSDHDMFEHSSSLN SWSLSEIPCSANNLFTCK**SN*LSVFGLCRL* PCFGRMFSIFSEFLPPI*LYFKYSILCTNLLSF WEL*WGFKGVRCQERRGKYSLLAGKSL*VCCV*N FRKSLI*FPFQTVFF*L*L*S*VCASIMKVTFL AFLGSISSYSHSHMGG*IFFLYPESLFSLPHGL VCCQIPVL*QIPQQFFPQWGGWKGGTDISKEMSS CVTVHFL*KKVF*EKVQNILESL*ASQSPHMDI WGCYLNTQQAECRYTCV*SVYTLLLFYNIVS*F WLCSLASILIISDGMP*NVLYCILLGRTLGFQRS LAALGL*RAQHDQSPKDFTSQLWLYVFPSGEVR LWLEEEKGWHERMTLIVVCPSNQHN*GSLPQHE NDDLAIFNGQSLKSGLSFCFRNE*EAFLQSSQEK WWSLGPWNG*PCA*RADGKGCLAWLIWVGFPQA YLSSLILCKE*LID*ASASGGLCWLFPDQRESL LTPSTSRGQSLGSRFS*FLTLKFKEAVEERMHYY HR*K*GTHRTLD*YLSALKCILVSLLELPKKGH KVFFLMEEVPRGCRAAK*QLH*MTLYFLALAYY LALGGPGELVITVALWEVKAPFGLALER*WHAWY SIWIIRKPP*SIHIVSEWD*QPWKSPLPKE*LL SWNFQSFWIFWIK*PTF*NLRSGVRDQPGNMVK PRLY*K*KKLARHGGGHL*SQLLRRLR*ENCLNP GDRGCIEPRSHHCTPAWAAEQDSISKKKKRKRK RRLILQLWRWDE*SLFDVKVGKEGVALRHLYSK LSWRFPVALLFLKGFHF*LHLFC*HPVQLR*SQR CIRTSSTGEATLPR*LKRKLVWAACCLLSSCNV FSLF*RTNVYYSVK*KCKILSV*NKSAITKDND FGTHFSLYPLSFLVLPGSFHNIVTAGPS*LCAF* RDATLG*SSLV*Y*RVGFGFIEYSVYLLGYTNT RCAV**RSH*R

Sequence NM_015375

GCCGCAAAGACAGAGCGGGCAGAGGCGATGGAGGGCGACGGGGTGCCATGGGGCAGCGAGCCCGTCTCGGGTCCCGGCCCCGGCGGCGGCGGAATGATCC GCGAGCTGTGCCGGGGCTTCGGCCGCTACCGCCGCTACCTGGGACGGCTGCGACAGAACCTGCGCGAGACCCAGAAGTTCTTCCGCGACATCAAGTGCTC CCACAACCACACTTGTCTCTCCTCCCTCACGGGCGGCGGCGGGGCCGAGCGCGGCCCTGCAGGCGATGTCGCCGAAACCGGGCTGCAGGCGGGCCAACTG AGCTGCATTTCCTTCCCACCTAAGGAAGAGAAGTACCTCCAGCAGATTGTGGACTGCCTCCCTTGCATACTGATCCTCGGCCAGGATTGTAACGTCAAGT GCCAGCTGTTGAATCTGCTGTTGGGGGTGCAGGTGCTTCCCACCACCAAGCTGGGCAGTGAGGAGAGCTGTAAGCTTCGGCGCCTCCGCTTCACCTATGG GACTCAGACTCGGGTCAGCCTGGCGCTCCCTGGACAGTATGAACTAGTGCACACGCTGGTTGCTCATCAGGGCAACTGGGAGACCATCCCTGAGGAGGAT CTGGAGGTCCAAGAGAACAATGAGGATGCTGCTCATGTTTTAGCGGAACTGGAGGTAACGATGCACCATGCTCTCTTACAGGAAGTGGACGTTGTGGTAG CACCATGCCAAGGCCTCCGGCCCACAGTGGATGTTCTGGGTGACTTGGTGAATGATTTCTTGCCTGTGATAACCTATGCACTCCACAAAGATGAACTCTC TGAGAGGGATGAGCAAGAGCTTCAGGAAATCCGAAAGTATTTCTCCTTTCCTGTATTCTTTTTCAAAGTGCCGAAACTGGGCTCGGAGATAATAGACTCC TCAACCAGGAGAATGGAGAGCGAAAGATCACCGCTTTATCGCCAGCTAATTGACCTGGGCTATCTGAGCAGCAGTCACTGGAACTGTGGGGCTCCTGGCC AGGATACTAAAGCTCAGAGCATGTTGGTGGAACAGAGTGAAAAGCTGAGACACTTGAGCACATTTTCTCACCAGGTGTTACAGACTCGCCTGGTGGATGC AGCCAAGGCCCTGAACCTGGTGCACTGCCACTGCCTTGACATCTTTATTAACCAGGCATTTGACATGCAGCGGGACCTGCAGATCACTCCCAAACGTCTG GAATATACTCGAAAAAAGGAGAATGAGTTGTATGAATCATTGATGAATATTGCCAACCGAAAGCAGGAGGAAATGAAGGATATGATTGTTGAGACACTTA ATACCATGAAGGAGGAACTTCTGGATGATGCTACTAACATGGAGTTTAAAGACGTCATTGTCCCTGAGAATGGAGAACCAGTAGGCACCAGAGAGATCAA ATGCTGCATCCGACAGATCCAGGAACTCATCATCTCCCGACTTAATCAGGCAGTGGCTAATAAGCTGATCAGCTCAGTGGATTACCTGAGGGAAAGCTTC GTCGGAACCCTGGAACGATGTCTGCAGAGCCTGGAGAAGTCTCAGGATGTCTCAGTTCACATCACCAGTAATTATCTCAAACAGATCTTAAATGCTGCCT ATCATGTTGAAGTCACGTTTCACTCAGGGTCGTCAGTTACAAGGATGCTATGGGAGCAAATCAAACAGATCATCCAGCGCATCACATGGGTGAGCCCACC TGCCATCACTCTGGAATGGAAGAGGAAGGTGGCCCAGGAAGCCATTGAGAGCCTCAGCGCCTCCAAATTGGCTAAGAGCATTTGCAGCCAATTCCGGACT CGGCTCAATAGTTCCCACGAGGCTTTTGCAGCCTCCTTGCGGCAGCTGGAAGCTGGCCACTCAGGCCGGTTAGAGAAAACGGAAGATCTATGGCTGAGGG TTCGGAAAGATCATGCTCCCCGCCTGGCCCGCCTTTCTCTGGAAAGCTGTTCTTTACAGGATGTCTTGCTTCATCGTAAACCTAAACTGGGACAGGAACT GGGCCGGGGCCAGTATGGTGTGGTATACCTGTGTGACAACTGGGGAGGACACTTCCCTTGTGCCCTCAAATCAGTTGTCCCTCCAGATGAGAAGCACTGG AATGATCTGGCTTTGGAATTTCACTATATGAGGTCTCTGCCGAAGCATGAGCGATTGGTGGATCTCCATGGTTCAGTCATTGACTACAACTATGGTGGTG GCTCCAGCATTGCTGTGCTCCTCATTATGGAGCGGCTACACCGGGATCTCTACACAGGGCTGAAGGCTGGGCTGACCCTGGAGACACGTTTGCAGATAGC ACTAGATGTGGTGGAGGGAATCCGCTTCCTGCACAGCCAGGGACTTGTCCATCGTGATATCAAACTGAAAAATGTGCTGCTGGATAAGCAGAACCGTGCC AAGATCACTGACTTAGGATTCTGCAAGCCAGAGGCCATGATGTCAGGCAGCATTGTGGGGACACCAATCCATATGGCCCCTGAACTTTTCACAGGGAAGT ACGATAATTCCGTGGATGTCTACGCTTTTGGAATTCTTTTCTGGTATATCTGCTCAGGCTCTGTCAAGCTCCCTGAGGCATTTGAGAGGTGTGCTAGCAA AGACCATCTCTGGAACAATGTGCGGAGGGGGGCTCGCCCAGAACGTCTTCCTGTGTTTGATGAGGAGTGCTGGCAGTTGATGGAAGCCTGTTGGGATGGC GACCCCTTGAAGAGGCCTCTCTTGGGCATTGTCCAGCCCATGCTCCAGGGCATCATGAATCGGCTCTGCAAGTCCAATTCTGAGCAGCCAAACAGAGGAC TAGATGATTCTACTTGAAAGCAAAGACCTTTCTCTTTCACTCTCTAGTTATTTCCTTCCCCCTCACCTTTTGGCCATGGGGAGAATTTGACATTTATTCA CTATAGGACACACTCCCAAGGGAACTGGTGCTTGCTGGGAAACTTGGAACCTTCCCAGGCAGGGATGACTCCTGGACAGTGAAGAGTTGAATGACTGAGC ATATTCAGCAGCTCACTGAAGCGCCAAGCTATCCCTTTAGCAAAAAAGTGTCTCAGATGTGTAAAAGCTGAGGAATGTGGTGTTCTGGCTTCACAAATGA AAAGGAGGCAGATGTTACCATTGTCTTTTCACTGTATATACTTCTAAGACAGCAAGCGGGACACTGCAGTGGCAATAGTGTTAAAAAATCTCATTCTCAT GATTTTTGGCTCTAGCTAGGAATAGTTTAGTCAGGACTCAGAAAATTTGAGCTTAGTTCTGGGATTATGAAAACATGGGGACAAAAACAATAACTTGTGG ATGTCTGGTTCCTGCTGTCTGCAGCCAGGTATCTCAGGTTGCAATGGTCAGAAGTCCCAGTGAGGGAGCTAGAAACAGAGCTATCTGTTCCTCATAGTGC CAGTGTGTTTACATTTATAGGACCACATATCCCTGGTTTCTGGGGGAGGGTTTCACTGTTACATCACCAAGAGGCCCTGAAAAGAGGAAAAAAAAAAAAA AAGAGGCCAGGCATGGTGGCTCACGCCTGTAATCTCAGCACTTTGGGAGGCTGAGGCGGGCGGATCACAAGGTCCAGAGTTCAAGAGCAGCCTGGCCAAC ATGGTGAAACCCCGTCTCTACTAAAGATACAAAAAATTAGCCGGGCGTGGTGGTGCATGCCTGTAATCCAAGATACTCAGGAGGCTGAGGCAGGAGAATC GCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCCGAGATCATGCCATTGCACTCCAGCCTGGGCGACAGAGTGAGACTCTGTCTCAAAAAAAAAAAAAAA ATAGAATGTGTATGCATATATTTGTGTGTATATGTATATATGTGTGTGTGTCTATATCTCTATCTATATAGACATACACACAGGAGTTATTGGATTTAGA GTTACTGCTAACCCCAGAACAGAATCTGTTCTTTTACCTTTGAGTCTTTTCTTTTGTTTACCTCTTTTCATCTCAAAGTGGGAAAGCTCCAGATAACATG GTACTTAGGAGTGAGTGTCTAAGCAAAACCAACCCAATGCGAAGTATTTGGGTGAGAACTGAGAGGTGGGAGATGATTGGAGGCCATGGCCTATGTACAA ACATACTGGAAGAAAACCAGCTTGTTTTTAAAACTTAACACAATCAGAAATTTTTCTTTTTGTGTTTGAATCTAACACACTGACGTTTGGAAAACTTGAT CAATGAGCTTTTAACCACGATTTCTCCCGCAATTTGTTCCTTCTTTTTACCTTTTTAAAAATCTGTTAGAAGAAAAAAAGCAGCAGACGAAAGAGAAAAA CCCTCCTCTGGTAGTTCTGTGTGTGCCCCTCACCCCTGTGTGCTAGTGTCTGGGAAGTTTCCCTGAAAGGTGGGAGGCGGGTGGGTGGTCTTTTGGAGGG TTCCTCATGAAGTGTGCTTGAGGAAAGAAATTCTGATTCTAGGCAGAGGAAGGGGAACAATTTAAATATTGGTGCATCTCAGATGCACTTGACTTCAAGC CTTCCTCAACCAAACTGGTCCATTAGATTCCGAAAAACAGGTAGACGAGGAAGTAGACAGTGGAAGTGAGTAGTCTCCCTCCATCTGCCTAATCCCCAAT AACTGTGGTCTGGCCCCTGTGTTCAGCCCGAGAGTTTGTAAAACAGGTCCCCAGGTAGGTGTATAAGATGAGTTGCAAATTAGCCGGGCATGCTGGCACG CACCAGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGCAGAGGTCATGGTGAGCCGAGATCACGCCACTGCACTCCAG CCTGGGCAACAGAGCGAGACTCTATCTCAAAAAAAAACAAAAAAAAAAACAAAAAACAAAGATGAGTCGCACATCTGCTGCTGGGATTTTCTAGGGTTGT CTATGACAGAATGACCATCTTTTAAATATTAATGGAGTATAAATGGAGTCTATAATGGGTCTTTCATATAACTTTTAACTCTTTGGCTATCCTGGGCTCT GATCATGATATGTTTGAGCATAGTAGCTCCCTAAACTCTTGGAGCCTTTCAGAAATTCCATGTAGTGCTAATAACCTTTTTACTTGCAAATGATAAAGTA ACTGACTCAGTGTCTTTGGGCTCTGCAGGCTTTAGCCTTGTTTTGGTAGGATGTTCAGTATATTCTCAGAATTTTTACCACCTATTTAGCTATACTTCAA GTACTCTATTCTCTGCACTAACTTACTGTCCTTCTGGGAACTATGATGGGGCTTCAAGGGAGTCAGGTGTCAAGAAAGGAGGGGTAAGTACTCTCTACTT GCTGGAAAATCATTGTAAGTCTGTTGTGTATGAAATTTTAGGAAAAGTCTTATATAGTTCCCTTTCCAGACTGTTTTCTTTTGACTCTAACTATAATCAT AAGTCTGTGCTTCCATTATGAAGGTCACATTCCTAGCATTCTTGGGAAGTATTAGCTCATACTCTCATTCACATATGGGAGGTTAGATTTTTTTCCTCTA CCCAGAGTCCCTTTTTAGTTTACCCCACGGCTTAGTTTGCTGTCAGATACCAGTTCTCTAGCAGATTCCCCAACAGTTTTTTCCCCAGTGGGGAGGGTGG AAGGGAGGGACTGATATAAGTAAGGAGATGAGTAGTTGTGTTACAGTTCATTTTCTTTAAAAAAAAGTATTTTGAGAAAAGGTGCAAAATATTCTTGAAA GTCTCTAGGCCAGCCAAAGTCCACATATGGATATTTGGGGATGTTATTTAAATACTCAGCAGGCTGAGTGCAGGTATACGTGTGTATAGAGTGTGTATAC TTTGCTTTTGTTTTATAACATTGTCAGCTAATTTTGGCTTTGTTCTTTGGCATCCATTCTTATTATAAGTGATGGAATGCCATGAAATGTACTGTATTGT ATATTACTTGGGAGGACACTAGGTTTTCAAAGAAGTCTGGCAGCACTTGGGTTATAGAGGGCTCAGCATGACCAAAGTCCTAAAGATTTTACCTCCCAGC TTTGGTTGTATGTGTTCCCAAGTGGTGAGGTGAGATTGTGGCTGGAGGAAGAAAAAGGATGGCATGAAAGAATGACCCTTATTGTGGTCTGTCCTTCTAA TCAACATAATTAGGGCAGCTTACCCCAACATGAAAATGATGACCTGGCCATTTTTAATGGCCAGAGCTTGAAGTCTGGTCTCTCATTTTGTTTCAGAAAT GAGTGAGAGGCCTTCCTGCAGAGCAGTCAGGAGAAATGGTGGAGCCTGGGGCCCTGGAATGGCTGACCCTGTGCCTAGAGAGCTGATGGCAAGGGCTGTC TGGCATGGCTCATTTGGGTGGGGTTTCCCCAGGCATACCTTAGTTCCCTGATCCTCTGCAAAGAGTAGCTCATTGACTGAGCAAGCGCTTCAGGAGGACT GTGCTGGTTGTTCCCAGACCAAAGAGAGTCACTTTTGACTCCATCAACTTCAAGGGGACAGAGCCTAGGCAGCAGATTCTCCTAATTTTTAACACTAAAA TTCAAGGAAGCAGTGGAGGAAAGAATGCATTACTACCACAGATAGAAATAGGGGACTCATAGAACTCTCGACTAGTACCTGTCAGCTCTCAAATGCATTC TTGTGTCTTTGCTTGAGCTGCCAAAGAAGGGTCACAAAGTGTTCTTCCTCATGGAAGAAGTGCCTCGGGGTTGCAGGGCTGCAAAGTGACAACTGCACTG AATGACACTTTATTTTTTGGCTTTGGCTTATTATTTAGCACTGGGAGGCCCAGGGGAATTGGTGATTACAGTAGCACTTTGGGAAGTTAAAGCCCCCTTT GGGCTTGCTTTGGAGAGATGATGGCATGCTTGGTATTCCATTTGGATAATCAGGAAGCCTCCCTAGTCCATCCATATTGTGTCAGAGTGGGATTAACAAC CCTGGAAGAGTCCACTGCCAAAAGAGTAGTTGCTTTCCTGGAATTTCCAAAGCTTTTGGATTTTCTGGATCAAGTAACCCACTTTTTAAAACCTGAGGTC AGGAGTTCGAGACCAGCCTGGTAACATGGTGAAACCCCGTCTCTATTAAAAATAGAAAAAATTAGCCAGGCATGGTGGCGGGCACCTATAGTCCCAGCTA CTCAGGAGGCTGAGGTAGGAGAATTGCTTGAACCCAGGAGACAGAGGCTGCATTGAGCCAAGATCACACCACTGCACTCCAGCCTGGGCAGCAGAGCAAG ACTCCATCTCAAAAAAAAAAAAAAGAAAAAGAAAAAGAAGGTTAATCCTTCAGTTATGGAGGTGGGATGAATAGAGCTTGTTTGATGTTAAAGTGGGTAA GGAGGGAGTGGCCTTGAGACACTTGTATTCCAAACTCTCCTGGAGGTTTCCAGTAGCACTACTGTTCCTAAAAGGGTTTCATTTTTAACTTCATCTGTTT TGTTAACATCCAGTCCAATTGAGGTGATCTCAGAGGTGCATCAGGACATCTAGCACTGGGGAGGCCACCTTGCCCAGATAGTTGAAAAGAAAATTGGTCT GGGCAGCCTGTTGTCTTTTGTCTTCATGTAATGTTTTTTCTTTGTTTTAAAGGACTAATGTTTATTACAGTGTTAAATAAAAGTGTAAGATACTAAGTGT GTAGAATAAAAGTGCAATAACAAAAGACAATGACTTTGGCACACACTTCAGTCTTTATCCTCTCTCCTTTCTTGTGCTACCTGGCTCTTTCCATAATATT GTTACAGCAGGACCGTCTTAATTGTGTGCATTTTGAAGAGATGCGACTCTGGGTTAATCTTCATTAGTGTAATATTGAAGGGTTGGGTTTGGTTTTATAG AGTATTCTGTATACTTGTTGGGATACACAAATACCAGATGTGCTGTATAATAAAGATCACATTAACGTTT

refseq_RIPK5.F1 (forward primer)
refseq_RIPK5.R1 (reverse primer)
Single exon skipping

Frame 0

AAKTERAEAMEGDGVPWGSEPVSGPGPGGGGMI RELCRGFGRYRRYLGRLRQNLRETQKFFRDIKCS HNHTCLSSLTGGGGAERGPAGDVAETGLQAGQL SCISFPPKEEKYLQQIVDCLPCILILGQDCNVK CQLLNLLLGVQVLPTTKLGSEESCKLRRLRFTYG TQTRVSLALPGQYELVHTLVAHQGNWETIPEED LEVQENNEDAAHVLAELEVTMHHALLQEVDVVV APCQGLRPTVDVLGDLVNDFLPVITYALHKDELS ERDEQELQEIRKYFSFPVFFFKVPKLGSEIIDS STRRMESERSPLYRQLIDLGYLSSSHWNCGAPG QDTKAQSMLVEQSEKLRHLSTFSHQVLQTRLVDA AKALNLVHCHCLDIFINQAFDMQRDLQITPKRL EYTRKKENELYESLMNIANRKQEEMKDMIVETL NTMKEELLDDATNMEFKDVIVPENGEPVGTREIK CCIRQIQELIISRLNQAVANKLISSVDYLRESF VGTLERCLQSLEKSQDVSVHITSNYLKQILNAA YHVEVTFHSGSSVTRMLWEQIKQIIQRITWVSPP AITLEWKRKVAQEAIESLSASKLAKSICSQFRT RLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLR VRKDHAPRLARLSLESCSLQDVLLHRKPKLGQEL GRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHW NDLALEFHYMRSLPKHERLVDLHGSVIDYNYGG GSSIAVLLIMERLHRDLYTGLKAGLTLETRLQIA LDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRA KITDLGFCKPEAMMSGSIVGTPIHMAPELFTGK YDNSVDVYAFGILFWYICSGSVKLPEAFERCASK DHLWNNVRRGARPERLPVFDEECWQLMEACWDG DPLKRPLLGIVQPMLQGIMNRLCKSNSEQPNRG LDDST*KQRPFSFTL*LFPSPSPFGHGENLTFIH YRTHSQGNWCLLGNLEPSQAGMTPGQ*RVE*LS IFSSSLKRQAIPLAKKCLRCVKAEECGVLASQM KRRQMLPLSFHCIYF*DSKRDTAVAIVLKNLILM IFGSS*E*FSQDSENLSLVLGL*KHGDKNNNLW MSGSCCLQPGISGCNGQKSQ*GS*KQSYLFLIV PVCLHL*DHISLVSGGGFHCYITKRP*KEEKKKK RGQAWWLTPVISALWEAEAGGSQGPEFKSSLAN MVKPRLY*RYKKLAGRGGACL*SKILRRLRQEN RLNLGGGGCSEPRSCHCTPAWATE*DSVSKKKKK *NVYAYICVYMYICVCVYISIYIDIHTGVIGFR VTANPRTESVLLPLSLFFCLPLFISKWESSR*H GT*E*VSKQNQPNAKYLGEN*EVGDDWRPWPMYK HTGRKPACF*NLTQSEIFLFVFESNTLTFGKLD Q*AFNHDFSRNLFLLFTFLKIC*KKKSSRRKRK TLLW*FCVCPSPLCASVWEVSLKGGRRVGGLLEG SS*SVLEERNSDSRQRKGNNLNIGASQMHLTSS LPQPNWSIRFRKTGRRGSRQWK*VVSLHLPNPQ *LWSGPCVQPESL*NRSPGRCIR*VAN*PGMLAR TSNPSYLGG*GRRIT*TREAEVMVSRDHATALQ PGQQSETLSQKKTKKKTKNKDESHICCWDFLGL SMTE*PSFKY*WSINGVYNGSFI*LLTLWLSWAL IMICLSIVAP*TLGAFQKFHVVLITFLLANDKV TDSVSLGSAGFSLVLVGCSVYSQNFYHLFSYTS STLFSALTYCPSGNYDGASRESGVKKGGVSTLYL LENHCKSVVYEILGKVLYSSLSRLFSFDSNYNH KSVLPL*RSHS*HSWEVLAHTLIHIWEVRFFSS TQSPFLVYPTA*FAVRYQFSSRFPNSFFPSGEGG REGLI*VRR*VVVLQFIFFKKKYFEKRCKIFLK VSRPAKVHIWIFGDVI*ILSRLSAGIRVYRVCI LCFCFITLSANFGFVLWHPFLL*VMECHEMYCIV YYLGGH*VFKEVWQHLGYRGLSMTKVLKILPPS FGCMCSQVVR*DCGWRKKKDGMKE*PLLWSVLL INIIRAAYPNMKMMTWPFLMARA*SLVSHFVSEM SERPSCRAVRRNGGAWGPGMADPVPRELMARAV WHGSFGWGFPRHTLVP*SSAKSSSLTEQALQED CAGCSQTKESHF*LHQLQGDRA*AADSPNF*H*N SRKQWRKECITTTDRNRGLIELSTSTCQLSNAF LCLCLSCQRRVTKCSSSWKKCLGVAGLQSDNCT E*HFIFWLWLII*HWEAQGNW*LQ*HFGKLKPPL GLLWRDDGMLGIPFG*SGSLPSPSILCQSGINN PGRVHCQKSSCFPGISKAFGFSGSSNPLFKT*G QEFETSLVTW*NPVSIKNRKN*PGMVAGTYSPSY SGG*GRRIA*TQETEAALSQDHTTALQPGQQSK TPSQKKKKEKEKEG*SFSYGGGMNRACLMLKWV RREWP*DTCIPNSPGGFQ*HYCS*KGFIFNFICF VNIQSN*GDLRGASGHLALGRPPCPDS*KENWS GQPVVFCLHVMFFLCFKGLMFITVLNKSVRY*V CRIKVQ*QKTMTLAHTSVFILSPFLCYLALSIIL LQQDRLNCVHFEEMRLWVNLH*CNIEGLGLVL* SILYTCWDTQIPDVLYNKDHINV

Frame 1

PQRQSGQRRWRATGCHGAASPSRVPAPAAAE*S ASCAGASAATAATWDGCDRTCARPRSSSATSSA PTTTLVSPPSRAAAGPSAALQAMSPKPGCRRAN* AAFPSHLRKRSTSSRLWTASLAY*SSARIVTSS ASC*ICCWGCRCFPPPSWAVRRAVSFGASASPM GLRLGSAWRSLDSMN*CTRWLLIRATGRPSLRRI WRSKRTMRMLLMF*RNWR*RCTMLSYRKWTLW* HHAKASGPQWMFWVTW*MISCL**PMHSTKMNS LRGMSKSFRKSESISPFLYSFSKCRNWARR**TP QPGEWRAKDHRFIAS*LTWAI*AAVTGTVGLLA RILKLRACWWNRVKS*DT*AHFLTRCYRLAWWM QPRP*TWCTATALTSLLTRHLTCSGTCRSLPNVW NILEKRRMSCMNH**ILPTESRRK*RI*LLRHL IP*RRNFWMMLLTWSLKTSLSLRMENQ*APERS NAASDRSRNSSSPDLIRQWLIS*SAQWIT*GKAS SEPWNDVCRAWRSLRMSQFTSPVIISNRS*MLP IMLKSRFTQGRQLQGCYGSKSNRSSSASHG*AH LPSLWNGRGRWPRKPLRASAPPNWLRAFAANSGL GSIVPTRLLQPPCGSWKLATQAG*RKRKIYG*G FGKIMLPAWPAFLWKAVLYRMSCFIVNLNWDRN WAGASMVWYTCVTTGEDTSLVPSNQLSLQMRSTG MIWLWNFTI*GLCRSMSDWWISMVQSLTTTMVV APALLCSSLWSGYTGISTQG*RLG*PWRHVCR* H*MWWRESASCTARDLSIVISN*KMCCWISRTVP RSLT*DSASQRP*CQAALWGHQSIWPLNFSQGS TIIPWMSTLLEFFSGISAQALSSSLRHLRGVLA KTISGTMCGGGLAQNVFLCLMRSAGS*WKPVGMA TP*RGLSWALSSPCSRAS*IGSASPILSSQTED *MILLESKDLSLSLSSYFLPPHLLAMGRI*HLF TIGHTPKGTGACWETWNLPRQG*LLDSEELND*A YSAAH*SAKLSL*QKSVSDV*KLRNVVFWLHK* KGGRCYHCLFTVYTSKTASGTLQWQ*C*KISFS *FLALARNSLVRTQKI*A*FWDYENMGTKTITCG CLVPAVCSQVSQVAMVRSPSEGARNRAICSS*C QCVYIYRTTYPWFLGEGFTVTSPRGPEKRKKKK KEARHGGSRL*SQHFGRLRRADHKVQSSRAAWPT W*NPVSTKDTKN*PGVVVHACNPRYSGG*GRRI A*TWEAEVAVSRDHAIALQPGRQSETLSQKKKK NRMCMHIFVCICIYVCVSISLSI*TYTQELLDLE LLLTPEQNLFFYL*VFSFVYLFSSQSGKAPDNM VLRSECLSKTNPMRSIWVRTERWEMIGGHGLCT NILEENQLVFKT*HNQKFFFLCLNLTH*RLENLI NELLTTISPAICSFFLPF*KSVRRKKAADEREK PSSGSSVCAPHPCVLVSGKFP*KVGGGWVVFWR VPHEVCLRKEILILGRGRGTI*ILVHLRCT*LQA FLNQTGPLDSEKQVDEEVDSGSE*SPSICLIPN NCGLAPVFSPRVCKTGPQVGV*DELQISRACWH APVIPATWEAEAGESLEPGRQRSW*AEITPLHSS LGNRARLYLKKKQKKKQKTKMSRTSAAGIF*GC L*QNDHLLNINGV*MESIMGLSYNF*LFGYPGL *S*YV*A**LPKLLEPFRNSM*C**PFYLQMIK* LTQCLWALQALALFW*DVQYILRIFTTYLAILQ VLYSLH*LTVLLGTMMGLQGSQVSRKEG*VLST CWKIIVSLLCMKF*EKSYIVPFPDCFLLTLTIII SLCFHYEGHIPSILGKY*LILSFTYGRLDFFPL PRVPF*FTPRLSLLSDTSSLADSPTVFSPVGRV EGRD*YK*GDE*LCYSSFSLKKSILRKGAKYS*K SLGQPKSTYGYLGMLFKYSAG*VQVYVCIECVY FAFVL*HCQLILALFFGIHSYYK*WNAMKCTVL YITWEDTRFSKKSGSTWVIEGSA*PKS*RFYLPA LVVCVPKW*GEIVAGGRKRMA*KNDPYCGLSF* ST*LGQLTPT*K**PGHF*WPELEVWSLILFQK *VRGLPAEQSGEMVEPGALEWLTLCLES*WQGLS GMAHLGGVSPGIP*FPDPLQRVAH*LSKRFRRT VLVVPRPKRVTFDSINFKGTEPRQQILLIFNTK IQGSSGGKNALLPQIEIGDS*NSRLVPVSSQMHS CVFA*AAKEGSQSVLPHGRSASGLQGCKVTTAL NDTLFFGFGLLFSTGRPRGIGDYSSTLGS*SPL WACFGEMMACLVFHLDNQEASLVHPYCVRVGLTT LEESTAKRVVAFLEFPKLLDFLDQVTHFLKPEV RSSRPAW*HGETPSLLKIEKISQAWWRAPIVPA TQEAEVGELLEPRRQRLH*AKITPLHSSLGSRAR LHLKKKKKKKKKKVNPSVMEVG*IELV*C*SG* GGSGLETLVFQTLLEVSSSTTVPKRVSFLTSSV LLTSSPIEVISEVHQDI*HWGGHLAQIVEKKIGL GSLLSFVFM*CFFFVLKD*CLLQC*IKV*DTKC VE*KCNNKRQ*LWHTLQSLSSLLSCATWLFP*Y CYSRTVLIVCILKRCDSGLIFISVILKGWVWFYR VFCILVGIHKYQMCCIIKITLTF

Frame 2

RKDRAGRGDGGRRGAMGQRARLGSRPRRRRNDP RAVPGLRPLPPLPGTAATEPARDPEVLPRHQVL PQPHLSLLPHGRRRGRARPCRRCRRNRAAGGPT ELHFLPT*GREVPPADCGLPPLHTDPRPGL*RQV PAVESAVGGAGASHHQAGQ*GEL*ASAPPLHLW DSDSGQPGAPWTV*TSAHAGCSSGQLGDHP*GG SGGPREQ*GCCSCFSGTGGNDAPCSLTGSGRCGS TMPRPPAHSGCSG*LGE*FLACDNLCTPQR*TL *EG*ARASGNPKVFLLSCILFQSAETGLGDNRL LNQENGERKITALSPAN*PGLSEQQSLELWGSWP GY*SSEHVGGTE*KAETLEHIFSPGVTDSPGGC SQGPEPGALPLP*HLY*PGI*HAAGPADHSQTS GIYSKKGE*VV*IIDEYCQPKAGGNEGYDC*DT* YHEGGTSG*CY*HGV*RRHCP*EWRTSRHQRDQ MLHPTDPGTHHLPT*SGSG**ADQLSGLPEGKL RRNPGTMSAEPGEVSGCLSSHHQ*LSQTDLKCCL SC*SHVSLRVVSYKDAMGANQTDHPAHHMGEPT CHHSGMEEEGGPGSH*EPQRLQIG*EHLQPIPD SAQ*FPRGFCSLLAAAGSWPLRPVRENGRSMAEG SERSCSPPGPPFSGKLFFTGCLASS*T*TGTGT GPGPVWCGIPV*QLGRTLPLCPQISCPSR*EAL E*SGFGISLYEVSAEA*AIGGSPWFSH*LQLWWW LQHCCAPHYGAATPGSLHRAEGWADPGDTFADS TRCGGGNPLPAQPGTCPS*YQTEKCAAG*AEPC QDH*LRILQARGHDVRQHCGDTNPYGP*TFHREV R*FRGCLRFWNSFLVYLLRLCQAP*GI*EVC*Q RPSLEQCAEGGSPRTSSCV**GVLAVDGSLLGW RPLEEASLGHCPAHAPGHHESALQVQF*AAKQRT R*FYLKAKTFLFHSLVISFPLTFWPWGEFDIYS L*DTLPRELVLAGKLGTFPGRDDSWTVKS*MTE HIQQLTEAPSYPFSKKVSQMCKS*GMWCSGFTNE KEADVTIVFSLYILLRQQAGHCSGNSVKKSHSH DFWL*LGIV*SGLRKFELSSGIMKTWGQKQ*LV DVWFLLSAARYLRLQWSEVPVRELETELSVPHSA SVFTFIGPHIPGFWGRVSLLHHQEALKRGKKKK KRPGMVAHACNLSTLGG*GGRITRSRVQEQPGQ HGETPSLLKIQKISRAWWCMPVIQDTQEAEAGES LEPGRRRLQ*AEIMPLHSSLGDRVRLCLKKKKK IECVCIYLCVYVYMCVCLYLYLYRHTHRSYWI* SYC*PQNRICSFTFESFLLFTSFHLKVGKLQITW YLGVSV*AKPTQCEVFG*ELRGGR*LEAMAYVQ TYWKKTSLFLKLNTIRNFSFCV*I*HTDVWKT* SMSF*PRFLPQFVPSFYLFKNLLEEKKQQTKEKN PPLVVLCVPLTPVC*CLGSFPERWEAGGWSFGG FLMKCA*GKKF*F*AEEGEQFKYWCISDALDFK PSSTKLVH*IPKNR*TRK*TVEVSSLPPSA*SPI TVVWPLCSAREFVKQVPR*VYKMSCKLAGHAGT HQ*SQLLGRLRQENHLNPGGRGHGEPRSRHCTP AWATERDSISKKNKKKNKKQR*VAHLLLGFSRVV YDRMTIF*ILMEYKWSL*WVFHITFNSLAILGS DHDMFEHSSSLNSWSLSEIPCSANNLFTCK**S N*LSVFGLCRL*PCFGRMFSIFSEFLPPI*LYFK YSILCTNLLSFWEL*WGFKGVRCQERRGKYSLL AGKSL*VCCV*NFRKSLI*FPFQTVFF*L*L*S *VCASIMKVTFLAFLGSISSYSHSHMGG*IFFLY PESLFSLPHGLVCCQIPVL*QIPQQFFPQWGGW KGGTDISKEMSSCVTVHFL*KKVF*EKVQNILE SL*ASQSPHMDIWGCYLNTQQAECRYTCV*SVYT LLLFYNIVS*FWLCSLASILIISDGMP*NVLYC ILLGRTLGFQRSLAALGL*RAQHDQSPKDFTSQ LWLYVFPSGEVRLWLEEEKGWHERMTLIVVCPSN QHN*GSLPQHENDDLAIFNGQSLKSGLSFCFRN E*EAFLQSSQEKWWSLGPWNG*PCA*RADGKGC LAWLIWVGFPQAYLSSLILCKE*LID*ASASGGL CWLFPDQRESLLTPSTSRGQSLGSRFS*FLTLK FKEAVEERMHYYHR*K*GTHRTLD*YLSALKCI LVSLLELPKKGHKVFFLMEEVPRGCRAAK*QLH* MTLYFLALAYYLALGGPGELVITVALWEVKAPF GLALER*WHAWYSIWIIRKPP*SIHIVSEWD*Q PWKSPLPKE*LLSWNFQSFWIFWIK*PTF*NLRS GVRDQPGNMVKPRLY*K*KKLARHGGGHL*SQL LRRLR*ENCLNPGDRGCIEPRSHHCTPAWAAEQ DSISKKKKRKRKRRLILQLWRWDE*SLFDVKVGK EGVALRHLYSKLSWRFPVALLFLKGFHF*LHLF C*HPVQLR*SQRCIRTSSTGEATLPR*LKRKLV WAACCLLSSCNVFSLF*RTNVYYSVK*KCKILSV *NKSAITKDNDFGTHFSLYPLSFLVLPGSFHNI VTAGPS*LCAF*RDATLG*SSLV*Y*RVGFGFI EYSVYLLGYTNTRCAV**RSH*R