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Sequences

Sequence NM_002955

TTCAGACACCTGAGAGCATCCTGTTCTGGGTACAGTGTGTGTATGTATATGTTTGTTTGAAGCCGCTGGTCCTCGCCTTTTACTCCTTAGCTGGACAGCG GGTTCGGGATCTGCCCCATGACTAAGGCTGAAGTGGAAAGTTGCGAAGATAGAACAAGAGTTGTTCCTTAGGGTGGTGTCCCTAAACTTGAAAGTGGACT TGGTCCTGCTCGCAGGTTGCTCCGACTGTGTGTTCCAGGAGTGGTGGCTCTGAGGTGTGACCCTGCCCACGTTTGGGCCCAGCCAGGTTCAGCCCCCCAA TAAGGAGGGCAGCTTGATAACACAAAGAAAACAGTGTCAACGAGTACTACCAAGAGAAGAAGACAAGAGGTCAACACAGACTCATTTTCTACTCCGTGTG AATGATAGCTACAGCAGGGGAAAGTTTCATAGTCTATCAGTGGGTCAGAAAATGGAGTTTTATAGCAGAGGCTTCTTAGAAGCTTAAACCCCTGTCCCAA TGACGTCAAGTTCGCCCGCTGGCTTGGAAGGTTCAGACCTATCTTCCATCAACACCATGATGTCGGCGGTCATGAGTGTAGGGAAGGTCACAGAGAATGG CGGGAGCCCCCAGGGGATCAAGTCCCCCTCGAAGCCTCCAGGACCAAATCGGATTGGCAGAAGGAACCAGGAAACGAAAGAGGAGAAGTCTTCCTATAAC TGCCCCCTGTGTGAGAAGATTTGCACTACCCAGCACCAGCTGACCATGCACATTCGCCAGCACAACACAGACACTGGAGGAGCCGACCACTCATGCAGCA TCTGCGGAAAGTCACTGAGCTCGGCCAGCTCCCTCGATCGCCACATGCTGGTGCACTCTGGCGAGAGGCCTTACAAGTGCACTGTGTGTGGCCAGTCATT TACCACCAATGGGAACATGCACAGACATATGAAGATCCATGAGAAGGACCCTAACAGTGCCACAGCCACAGCCCCTCCATCTCCTCTGAAACGTAGGCGA TTGTCCTCCAAGAGGAAACTGAGTCACGATGCCGAGTCAGAGAGAGAAGACCCAGCACCAGCTAAAAAGATGGTAGAAGACGGGCAGTCAGGTGACTTGG AGAAGAAAGCTGATGAAGTCTTTCACTGCCCAGTATGTTTCAAGGAGTTTGTTTGCAAGTATGGACTGGAGACCCACATGGAGACCCATTCAGATAACCC ACTAAGATGTGACATTTGTTGTGTCACCTTTCGAACACATCGAGGACTGCTGCGTCACAACGCGCTTGTCCACAAACAACTTCCCAGGGATGCAATGGGC AGACCTTTCATACAGAACAACCCTTCAATTCCTGCTGGCTTCCACGACTTAGGATTCACGGACTTCTCCTGTAGGAAGTTTCCTCGCATTTCTCAGGCCT GGTGCGAAACAAACCTGCGGAGGTGCATCAGCGAGCAACACCGTTTTGTCTGCGACACCTGTGACAAGGCGTTCCCCATGCTCTGCTCACTGGCTCTGCA CAAGCAGACCCATGTGGCGGCAGACCAGGGTCAAGAAAAGCCGCAGGCCACGCCCCTGCCTGGTGACGCCCTGGACCAGAAGGGCTTCCTGGCCTTGCTT GGCCTGCAGCACACCAAAGACGTCAGGCCTGCCCCCGCCGAGGAGCCCCTGCCGGATGACAACCAGGCAATTCAGCTCCAGACACTCAAGTGTCAGCTAC CTCAGGACCCCGGCTGCACCAACCTGCTGAGCCTGTCACCTTTCGAAGCTGCTTCCCTAGGCGGTTCTCTCACAGTTCTCCCCGCGACCAAGGACAGCAT AAAGCACCTGTCCCTGCAGCCCTTCCAGAAGGGCTTCATCATCCAGCCTGACAGCAGCATTGTGGTCAAGCCCATCTCTGGCGAGTCGGCCATCGAGCTG GCAGACATCCAGCAAATTCTGAAGATGGCAGCCTCGGCTCCCCCTCAGATCAGTCTTCCGCCCTTCTCCAAGGCCCCTGCCGCCCCACTGCAGGCGATCT TCAAGCACATGCCCCCTCTGAAGCCAAAGCCCCTGGTCACACCACGGACGGTGGTGGCCACCTCCACGCCCCCGCCTCTCATCAACGCCCAGCAGGCTTC CCCGGGCTGTATCAGCCCCAGCCTGCCGCCACCGCCCCTGAAGCTCCTCAAAGGCTCAGTGGAGGCGGCCTCCAACGCCCACCTGCTGCAGTCCAAGTCC GGGACCCAGCCCCACGCGGCCACGCGGCTCTCCCTGCAGCAGCCGCGGGCGGAGCTGCCGGGCCAGCCTGAGATGAAGACGCAGCTGGAGCAGGACAGCA TCATCGAGGCCCTGCTGCCGCTGAGCATGGAGGCCAAGATCAAGCAGGAGATCACAGAGGGGGAACTCAAGGCCTTCATGACAGCGCCCGGCGGCAAGAA GACGCCCGCCATGCGCAAGGTGCTCTACCCCTGCCGCTTCTGCAACCAGGTGTTTGCCTTCTCGGGGGTCTTGCGTGCCCACGTGCGCTCCCACCTGGGC ATCTCGCCATACCAGTGCAACATCTGCGACTACATCGCCGCCGACAAGGCCGCGCTCATCCGCCACCTGCGCACGCACAGTGGGGAGCGGCCCTACATTT GCAAGATCTGCCACTACCCCTTCACTGTCAAAGCCAACTGCGAGCGGCACCTGCGCAAGAAGCACCTCAAGGCCACCCGCAAGGATATCGAGAAGAACAT CGAGTATGTGAGTAGCAGCGCGGCCGAGCTGGTGGACGCCTTCTGCGCCCCGGACACCGTGTGCCGGCTGTGCGGCGAGGACCTCAAGCACTATCGTGCC CTGCGCATCCACATGCGCACGCACTGCGGCCGCGGCCTGGGCGGGGGCCACAAGGGCCGCAAGCCCTTCGAGTGCAAGGAGTGCAGCGCCGCGTTCGCGG CCAAGCGCAACTGCATCCACCACATCCTCAAGCAGCACCTGCACGTGCCCGAGCAGGACATCGAGAGCTACGTGCTGGCCGCCGACGGCCTGGGCCCCGC AGAGGCGCCGGCCGCTGAGGCGTCGGGGCGCGGGGAGGACAGTGGCTGCGCTGCCCTTGGTGACTGCAAGCCCCTCACTGCCTTCCTGGAACCCCAGAAC GGCTTTCTTCACAGGGGCCCCACCCAGCCTCCACCTCCCCATGTCTCGATCAAGTTGGAGCCCGCCAGTAGCTTTGCGGTGGACTTCAATGAGCCCCTGG ACTTCTCGCAGAAGGGCCTGGCCCTGGTCCAAGTGAAGCAGGAAAACATCTCCTTTCTGAGCCCTTCTTCCCTGGTCCCCTATGACTGCTCCATGGAGCC CATCGACCTGTCCATCCCCAAGAACTTCAGGAAAGGGGACAAGGATTTGGCCACTCCCAGCGAAGCCAAGAAGCCTGAGGAGGAGGCGGGGAGCAGCGAG CAGCCCTCTCCCTGCCCAGCACCCGGCCCTTCTCTTCCTGTAACTTTGGGGCCCAGCGGAATCCTGGAAAGCCCCATGGCCCCTGCTCCGGCGGCCACCC CGGAACCCCCAGCACAGCCCCTGCAGGGCCCTGTTCAGCTGGCGGTCCCAATCTACTCCTCAGCCCTGGTCAGCAGCCCTCCACTCGTGGGCAGCTCAGC CCTCCTGAGTGGCACAGCCTTGCTGCGTCCACTGCGGCCCAAGCCCCCGCTGCTTTTGCCAAAGCCCCCCGTGACAGAAGAGCTGCCCCCGCTGGCCTCC ATTGCCCAGATCATCTCATCTGTATCCTCGGCCCCCACCCTGCTGAAAACCAAGGTGGCGGACCCAGGGCCCGCAAGCACTGGCAGTAACACCACGGCTT CAGACAGCTTAGGAGGTTCTGTCCCCAAAGCCGCCACCACCGCCACCCCCGCTGCCACCACCAGCCCAAAAGAGTCTAGTGAGCCTCCCGCTCCAGCCAG CAGCCCAGAGGCTGCCTCTCCCACCGAGCAGGGCCCAGCGGGCACGTCGAAGAAGAGGGGCCGGAAAAGGGGGATGAGGAGCCGACCCCGCGCCAACAGC GGCGGGGTGGACCTGGACTCCAGCGGGGAGTTTGCCAGCATCGAGAAGATGCTGGCCACCACAGACACCAACAAGTTCAGTCCGTTTCTGCAGACAGCGG AGGACAACACTCAGGATGAGGTGGCCGGAGCCCCTGCCGACCACCATGGGCCCAGTGATGAAGAGCAGGGCAGTCCCCCAGAAGACAAGCTGCTGAGGGC CAAGCGGAACTCGTACACCAACTGCCTGCAGAAGATCACCTGTCCCCACTGTCCCCGGGTTTTCCCTTGGGCCAGCTCCCTACAGAGGCACATGCTCACA CACACTGACAGTCAGTCGGATGCGGAGACTGCAGCCGCCGCGGGCGAAGTGCTAGACCTCACCTCACGGGACAGAGAGCAGCCGTCGGAGGGCGCCACTG AGCTCCGCCAGGTCGCAGGGGATGCGCCTGTGGAGCAGGCCACGGCGGAAACGGCCTCGCCGGTGCACCGGGAAGAGCACGGGCGTGGGGAGAGCCATGA GCCGGAGGAGGAGCATGGCACTGAGGAGAGCACTGGGGACGCCGACGGCGCGGAAGAGGACGCGTCGAGCAACCAGAGCCTGGACCTGGACTTCGCCACC AAGCTCATGGACTTCAAGCTGGCGGAGGGCGACGGCGAGGCAGGCGCCGGGGGCGCGGCCTCGCAGGAGCAGAAGCTCGCCTGCGACACCTGTGGGAAGA GCTTCAAGTTCCTGGGCACCCTGAGCCGCCACCGGAAGGCGCACGGCCGCCAGGAGCCCAAGGACGAGAAGGGAGATGGCGCCAGCACTGCAGAGGAGGG GCCCCAGCCCGCCCCTGAACAGGAGGAGAAGCCCCCCGAGACCCCGGCAGAGGTGGTGGAGTCGGCCCCGGGTGCCGGGGAGGCCCCGGCGGAAAAGCTC GCGGAGGAGACGGAGGGCCCCTCCGACGGGGAGAGCGCGGCCGAGAAAAGGTCCTCAGAGAAGAGCGACGATGACAAGAAACCAAAGACAGACTCCCCCA AAAGCGTGGCCAGCAAGGCAGACAAGAGGAAGAAGGTCTGCAGCGTGTGCAACAAGCGGTTCTGGTCGCTGCAGGACCTGACCCGGCACATGCGCTCCCA CACAGGGGAAAGGCCATACAAATGTCAGACCTGCGAGCGAACCTTCACCTTGAAGCACAGCCTGGTTCGCCACCAGCGGATCCACCAGAAAGCCAGGCAT GCCAAACACCACGGGAAGGACAGCGACAAGGAAGAGCGGGGTGAGGAGGACAGCGAGAATGAGTCCACCCACAGCGGCAACAACGCCGTCTCAGAGAACG AGGCTGAGCTGGCTCCCAATGCCAGCAACCACATGGCTGTCACCCGGAGCCGGAAGGAGGGCTTGGCCAGTGCCACCAAGGACTGCAGCCACAGGGAGGA GAAGGTCACGGCAGGGTGGCCGTCTGAGCCTGGCCAGGGTGACCTTAACCCAGAGAGCCCGGCGGCCCTGGGGCAGGACCTGCTGGAGCCGCGCAGCAAG AGGCCTGCCCACCCAATCCTGGCCACAGCTGATGGCGCCTCCCAGCTCGTGGGGATGGAGTGACAGCCTCAGTCCCCCTCAGCACAGACAAAAGCCAGCA GAGCAAAGCGTCTATACTTCATGGGGTTTCCTCAGTGCCCTTTGGCTGTTGAGGAGTGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAC AAGCAGGAGCGTGGCTGCTCGCTCAGTGCCATAGCCTTACCGCAGCCTGCGCGGGAGGCCACAGCCCGTGCCGATTCCAGTGCCTTAACTACTTACCGGA TCCCTCCATATTATCATGGGTGTTGTATTTTTCCAAAATGACTTCTTAAACAAAACAAATATTATAATGAATTGTCTGGAGAGGACCTCTTCATTTGAGC ATTAGCGTTATTTTGTATTGGTGTGTGTGAGCTTGTTCTTGTGAATCTGTGATAGCACCGTTTGTTCTGTGAGCTGGAAACAGAAGGAAAAAACATACCC TTGGGTACCCATAGCCAATAACTGGAAGAAAATGATGTGAATTTCATGTAAATGACCAGAGGAAAGATGGATAAGATGATAATTTCTTAAATAGACATTT TCCTTTTTTCTTTGTGCTTCATGGTGGAGCTGTCATCTGGTCCTTGGTATTACAGGATGTGGTTGATGAAGGTTTCCAATATGGTTTCAGGCCAAAACCA GGGAAGATTCTAGCTTCAGCCTCATGTCCATTTCCAGTCTGTCAGCATTAGACATGGTCACTGTTCAAGTTTCAAGACATCCATTCTTAACTATAGAGAA GAGTTACTCCCCTGGCGTCTTAACCTATGGAAAACATGCACGGATAGGATATATTTGATTGCCTCCTCTTCCCTTTCAGTATATGTATTATTAATATTAT TATTATTATTATTATTATTAGTTCATCAGTTTGCTGTTCTCTGCAGTGAGCAGAATCAAATGGGCAATATTTGTCCTGGGAGACCTGTGCCGCACCCAGG TCCCCGTGTTAACGTGTGCCTGCGGTTGTGGTTGGCACCCTCGGGTGGTAGCTCTTCTACTGTAATGAGACAAGCCTTTCTTCTGTCACTGCAGAATTTA GAAGGGGCCGTGAGCAGTCTTCCCAAGCATGGTCCAGGAGCAGCTCAGAGAGGGTGGAGTGAGGATGCATGCATCCAGGGAACAGGCATCAAGAAGCCAG GGCCGTGCCTGGAGCACTGCAGAGATGACTTTGGAGAAAGCAAAGCAGTGACCCAGTGACCAGGCACATTACTCGTGAGCGAGGTATTCCCAGTCTTCCT GCTAAGCCTAATCCAAGCCTTACCCAGCTGTGCTACTGTCATTTGCAAAGCAAGGAAATACTACTACTGGTAATAAAACTACACATGCAAGATGTCAGAT AAGAAATAGGTTTATATTTACCTTCCTGCGATGTGGGGTTGGTGCTTGAAGATAAATGTGCTGTTTCTAGTTTCTTAAATAGCCCACACCCCTGGATGCA AAAAGGCAGGGTTATTTTTACCCATGAGCATCCTGTGCAGGCAATAGACTTCCCTCACTGTCTCCGCCTGCAGGGAGGAGAATGTACCCCACTGCACCTG AGCTCCTGGTCCCTCAGCCAAGACCTCAGGGGTCCCCAGCCAGCCTGCTGCTGGGGACCCCTGTGCTTGCTGCAGTGTATGGAGCCTCTTGCCTTCCCCT GGGGAGGCACCCCTGTACCCCAGCTTCCTTCCCCTGGCCTTTTCTGGCCCCAGTGCTCCTCCTTTACATAGACTTGTTCACACAGAAACGTGCACGCCCC CTTTTCTCCGCCACTTCACCAGTTTCTGAAATCCAACCTCCCAGACTTCACAGGAAGATAGATATTCTTGAGATAATGAAAAGTGATATCTTCGCATACG AAAGGAAAAAAGGTTGAGGTATATATGATTTTTAACTGTATTAGGGGTGTATGAACCAGTTTAAAAACGAGGTTTTATTTACTGTAGAGATGAATGCAAA TCAGAACCAATGATCCCTTGGCCTACTTAGTTAAAACCAGTTCATACATCCCTTAGG

refseq_RREB1.F1 (forward primer)
refseq_RREB1.R1 (reverse primer)
Single exon skipping

Frame 0

FRHLRASCSGYSVCMYMFV*SRWSSPFTP*LDS GFGICPMTKAEVESCEDRTRVVP*GGVPKLESGL GPARRLLRLCVPGVVALRCDPAHVWAQPGSAPQ *GGQLDNTKKTVSTSTTKRRRQEVNTDSFSTPC E**LQQGKVS*SISGSENGVL*QRLLRSLNPCPN DVKFARWLGRFRPIFHQHHDVGGHECREGHREW REPPGDQVPLEASRTKSDWQKEPGNERGEVFL* LPPV*EDLHYPAPADHAHSPAQHRHWRSRPLMQH LRKVTELGQLPRSPHAGALWREALQVHCVWPVI YHQWEHAQTYEDP*EGP*QCHSHSPSISSET*A IVLQEETESRCRVRERRPSTS*KDGRRRAVR*LG EES**SLSLPSMFQGVCLQVWTGDPHGDPFR*P TKM*HLLCHLSNTSRTAASQRACPQTTSQGCNG QTFHTEQPFNSCWLPRLRIHGLLL*EVSSHFSGL VRNKPAEVHQRATPFCLRHL*QGVPHALLTGSA QADPCGGRPGSRKAAGHAPAW*RPGPEGLPGLA WPAAHQRRQACPRRGAPAG*QPGNSAPDTQVSAT SGPRLHQPAEPVTFRSCFPRRFSHSSPRDQGQH KAPVPAALPEGLHHPA*QQHCGQAHLWRVGHRA GRHPANSEDGSLGSPSDQSSALLQGPCRPTAGDL QAHAPSEAKAPGHTTDGGGHLHAPASHQRPAGF PGLYQPQPAATAPEAPQRLSGGGLQRPPAAVQV RDPAPRGHAALPAAAAGGAAGPA*DEDAAGAGQH HRGPAAAEHGGQDQAGDHRGGTQGLHDSARRQE DARHAQGALPLPLLQPGVCLLGGLACPRALPPG HLAIPVQHLRLHRRRQGRAHPPPAHAQWGAALHL QDLPLPLHCQSQLRAAPAQEAPQGHPQGYREEH RVCE*QRGRAGGRLLRPGHRVPAVRRGPQALSC PAHPHAHALRPRPGRGPQGPQALRVQGVQRRVRG QAQLHPPHPQAAPARARAGHRELRAGRRRPGPR RGAGR*GVGARGGQWLRCPW*LQAPHCLPGTPE RLSSQGPHPASTSPCLDQVGARQ*LCGGLQ*APG LLAEGPGPGPSEAGKHLLSEPFFPGPL*LLHGA HRPVHPQELQERGQGFGHSQRSQEA*GGGGEQR AALSLPSTRPFSSCNFGAQRNPGKPHGPCSGGHP GTPSTAPAGPCSAGGPNLLLSPGQQPSTRGQLS PPEWHSLAASTAAQAPAAFAKAPRDRRAAPAGL HCPDHLICILGPHPAENQGGGPRARKHWQ*HHGF RQLRRFCPQSRHHRHPRCHHQPKRV**ASRSSQ QPRGCLSHRAGPSGHVEEEGPEKGDEEPTPRQQ RRGGPGLQRGVCQHREDAGHHRHQQVQSVSADSG GQHSG*GGRSPCRPPWAQ**RAGQSPRRQAAEG QAELVHQLPAEDHLSPLSPGFPLGQLPTEAHAH TH*QSVGCGDCSRRGRSARPHLTGQRAAVGGRH* APPGRRGCACGAGHGGNGLAGAPGRARAWGEP* AGGGAWH*GEHWGRRRRGRGRVEQPEPGPGLRH QAHGLQAGGGRRRGRRRGRGLAGAEARLRHLWEE LQVPGHPEPPPEGARPPGAQGREGRWRQHCRGG APARP*TGGEAPRDPGRGGGVGPGCRGGPGGKA RGGDGGPLRRGERGREKVLREERR*QETKDRLPQ KRGQQGRQEEEGLQRVQQAVLVAAGPDPAHALP HRGKAIQMSDLRANLHLEAQPGSPPADPPESQA CQTPREGQRQGRAG*GGQRE*VHPQRQQRRLRER G*AGSQCQQPHGCHPEPEGGLGQCHQGLQPQGG EGHGRVAV*AWPG*P*PREPGGPGAGPAGAAQQ EACPPNPGHS*WRLPARGDGVTASVPLSTDKSQQ SKASILHGVSSVPFGC*GVRERERERERERERD KQERGCSLSAIALPQPAREATARADSSALTTYR IPPYYHGCCIFPK*LLKQNKYYNELSGEDLFI*A LALFCIGVCELVLVNL**HRLFCELETEGKNIP LGTHSQ*LEENDVNFM*MTRGKMDKMIIS*IDI FLFSLCFMVELSSGPWYYRMWLMKVSNMVSGQNQ GRF*LQPHVHFQSVSIRHGHCSSFKTSILNYRE ELLPWRLNLWKTCTDRIYLIASSSLSVYVLLIL LLLLLLLVHQFAVLCSEQNQMGNICPGRPVPHPG PRVNVCLRLWLAPSGGSSSTVMRQAFLLSLQNL EGAVSSLPKHGPGAAQRGWSEDACIQGTGIKKP GPCLEHCRDDFGESKAVTQ*PGTLLVSEVFPVFL LSLIQALPSCATVICKARKYYYW**NYTCKMSD KK*VYIYLPAMWGWCLKINVLFLVS*IAHTPGC KKAGLFLPMSILCRQ*TSLTVSACREENVPHCT* APGPSAKTSGVPSQPAAGDPCACCSVWSLLPSP GEAPLYPSFLPLAFSGPSAPPLHRLVHTETCTP PFLRHFTSF*NPTSQTSQEDRYS*DNEK*YLRIR KEKRLRYI*FLTVLGVYEPV*KRGFIYCRDECK SEPMIPWPT*LKPVHTSLR

Frame 1

SDT*EHPVLGTVCVCICLFEAAGPRLLLLSWTA GSGSAP*LRLKWKVAKIEQELFLRVVSLNLKVD LVLLAGCSDCVFQEWWL*GVTLPTFGPSQVQPPN KEGSLITQRKQCQRVLPREEDKRSTQTHFLLRV NDSYSRGKFHSLSVGQKMEFYSRGFLEA*TPVP MTSSSPAGLEGSDLSSINTMMSAVMSVGKVTENG GSPQGIKSPSKPPGPNRIGRRNQETKEEKSSYN CPLCEKICTTQHQLTMHIRQHNTDTGGADHSCS ICGKSLSSASSLDRHMLVHSGERPYKCTVCGQSF TTNGNMHRHMKIHEKDPNSATATAPPSPLKRRR LSSKRKLSHDAESEREDPAPAKKMVEDGQSGDL EKKADEVFHCPVCFKEFVCKYGLETHMETHSDNP LRCDICCVTFRTHRGLLRHNALVHKQLPRDAMG RPFIQNNPSIPAGFHDLGFTDFSCRKFPRISQA WCETNLRRCISEQHRFVCDTCDKAFPMLCSLALH KQTHVAADQGQEKPQATPLPGDALDQKGFLALL GLQHTKDVRPAPAEEPLPDDNQAIQLQTLKCQL PQDPGCTNLLSLSPFEAASLGGSLTVLPATKDSI KHLSLQPFQKGFIIQPDSSIVVKPISGESAIEL ADIQQILKMAASAPPQISLPPFSKAPAAPLQAI FKHMPPLKPKPLVTPRTVVATSTPPPLINAQQAS PGCISPSLPPPPLKLLKGSVEAASNAHLLQSKS GTQPHAATRLSLQQPRAELPGQPEMKTQLEQDS IIEALLPLSMEAKIKQEITEGELKAFMTAPGGKK TPAMRKVLYPCRFCNQVFAFSGVLRAHVRSHLG ISPYQCNICDYIAADKAALIRHLRTHSGERPYI CKICHYPFTVKANCERHLRKKHLKATRKDIEKNI EYVSSSAAELVDAFCAPDTVCRLCGEDLKHYRA LRIHMRTHCGRGLGGGHKGRKPFECKECSAAFA AKRNCIHHILKQHLHVPEQDIESYVLAADGLGPA EAPAAEASGRGEDSGCAALGDCKPLTAFLEPQN GFLHRGPTQPPPPHVSIKLEPASSFAVDFNEPL DFSQKGLALVQVKQENISFLSPSSLVPYDCSMEP IDLSIPKNFRKGDKDLATPSEAKKPEEEAGSSE QPSPCPAPGPSLPVTLGPSGILESPMAPAPAAT PEPPAQPLQGPVQLAVPIYSSALVSSPPLVGSSA LLSGTALLRPLRPKPPLLLPKPPVTEELPPLAS IAQIISSVSSAPTLLKTKVADPGPASTGSNTTA SDSLGGSVPKAATTATPAATTSPKESSEPPAPAS SPEAASPTEQGPAGTSKKRGRKRGMRSRPRANS GGVDLDSSGEFASIEKMLATTDTNKFSPFLQTA EDNTQDEVAGAPADHHGPSDEEQGSPPEDKLLRA KRNSYTNCLQKITCPHCPRVFPWASSLQRHMLT HTDSQSDAETAAAAGEVLDLTSRDREQPSEGAT ELRQVAGDAPVEQATAETASPVHREEHGRGESHE PEEEHGTEESTGDADGAEEDASSNQSLDLDFAT KLMDFKLAEGDGEAGAGGAASQEQKLACDTCGK SFKFLGTLSRHRKAHGRQEPKDEKGDGASTAEEG PQPAPEQEEKPPETPAEVVESAPGAGEAPAEKL AEETEGPSDGESAAEKRSSEKSDDDKKPKTDSP KSVASKADKRKKVCSVCNKRFWSLQDLTRHMRSH TGERPYKCQTCERTFTLKHSLVRHQRIHQKARH AKHHGKDSDKEERGEEDSENESTHSGNNAVSEN EAELAPNASNHMAVTRSRKEGLASATKDCSHREE KVTAGWPSEPGQGDLNPESPAALGQDLLEPRSK RPAHPILATADGASQLVGME*QPQSPSAQTKAS RAKRLYFMGFPQCPLAVEE*ERERERERERERET SRSVAARSVP*PYRSLRGRPQPVPIPVP*LLTG SLHIIMGVVFFQNDFLNKTNIIMNCLERTSSFE H*RYFVLVCVSLFL*ICDSTVCSVSWKQKEKTYP WVPIANNWKKMM*ISCK*PEERWIR**FLK*TF SFFLCASWWSCHLVLGITGCG**RFPIWFQAKT REDSSFSLMSISSLSALDMVTVQVSRHPFLTIEK SYSPGVLTYGKHARIGYI*LPPLPFQYMYY*YY YYYYYY*FISLLFSAVSRIKWAIFVLGDLCRTQ VPVLTCACGCGWHPRVVALLL**DKPFFCHCRI* KGP*AVFPSMVQEQLREGGVRMHASREQASRSQ GRAWSTAEMTLEKAKQ*PSDQAHYS*ARYSQSS C*A*SKPYPAVLLSFAKQGNTTTGNKTTHARCQI RNRFIFTFLRCGVGA*R*MCCF*FLK*PTPLDA KRQGYFYP*ASCAGNRLPSLSPPAGRRMYPTAP ELLVPQPRPQGSPASLLLGTPVLAAVYGASCLPL GRHPCTPASFPWPFLAPVLLLYIDLFTQKRARP LFSATSPVSEIQPPRLHRKIDILEIMKSDIFAY ERKKG*GIYDF*LY*GCMNQFKNEVLFTVEMNAN QNQ*SLGLLS*NQFIHPL

Frame 2

QTPESILFWVQCVYVYVCLKPLVLAFYSLAGQR VRDLPHD*G*SGKLRR*NKSCSLGWCP*T*KWT WSCSQVAPTVCSRSGGSEV*PCPRLGPARFSPP IRRAA**HKENSVNEYYQEKKTRGQHRLIFYSV* MIATAGESFIVYQWVRKWSFIAEAS*KLKPLSQ *RQVRPLAWKVQTYLPSTP*CRRS*V*GRSQRM AGAPRGSSPPRSLQDQIGLAEGTRKRKRRSLPIT APCVRRFALPSTS*PCTFASTTQTLEEPTTHAA SAESH*ARPAPSIATCWCTLARGLTSALCVASH LPPMGTCTDI*RSMRRTLTVPQPQPLHLL*NVGD CPPRGN*VTMPSQREKTQHQLKRW*KTGSQVTW RRKLMKSFTAQYVSRSLFASMDWRPTWRPIQIT H*DVTFVVSPFEHIEDCCVTTRLSTNNFPGMQWA DLSYRTTLQFLLASTT*DSRTSPVGSFLAFLRP GAKQTCGGASASNTVLSATPVTRRSPCSAHWLC TSRPMWRQTRVKKSRRPRPCLVTPWTRRASWPCL ACSTPKTSGLPPPRSPCRMTTRQFSSRHSSVSY LRTPAAPTC*ACHLSKLLP*AVLSQFSPRPRTA *STCPCSPSRRASSSSLTAALWSSPSLASRPSSW QTSSKF*RWQPRLPLRSVFRPSPRPLPPHCRRS SSTCPL*SQSPWSHHGRWWPPPRPRLSSTPSRL PRAVSAPACRHRP*SSSKAQWRRPPTPTCCSPSP GPSPTRPRGSPCSSRGRSCRASLR*RRSWSRTA SSRPCCR*AWRPRSSRRSQRGNSRPS*QRPAAR RRPPCARCSTPAASATRCLPSRGSCVPTCAPTWA SRHTSATSATTSPPTRPRSSATCARTVGSGPTF ARSATTPSLSKPTASGTCARSTSRPPARISRRT SSM*VAARPSWWTPSAPRTPCAGCAARTSSTIVP CASTCARTAAAAWAGATRAASPSSARSAAPRSR PSATASTTSSSSTCTCPSRTSRATCWPPTAWAP QRRRPLRRRGAGRTVAALPLVTASPSLPSWNPRT AFFTGAPPSLHLPMSRSSWSPPVALRWTSMSPW TSRRRAWPWSK*SRKTSPF*ALLPWSPMTAPWS PSTCPSPRTSGKGTRIWPLPAKPRSLRRRRGAAS SPLPAQHPALLFL*LWGPAESWKAPWPLLRRPP RNPQHSPCRALFSWRSQSTPQPWSAALHSWAAQ PS*VAQPCCVHCGPSPRCFCQSPP*QKSCPRWPP LPRSSHLYPRPPPC*KPRWRTQGPQALAVTPRL QTA*EVLSPKPPPPPPPLPPPAQKSLVSLPLQP AAQRLPLPPSRAQRARRRRGAGKGG*GADPAPTA AGWTWTPAGSLPASRRCWPPQTPTSSVRFCRQR RTTLRMRWPEPLPTTMGPVMKSRAVPQKTSC*G PSGTRTPTACRRSPVPTVPGFSLGPAPYRGTCSH TLTVSRMRRLQPPRAKC*TSPHGTESSRRRAPL SSARSQGMRLWSRPRRKRPRRCTGKSTGVGRAM SRRRSMALRRALGTPTARKRTRRATRAWTWTSPP SSWTSSWRRATARQAPGARPRRSRSSPATPVGR ASSSWAP*AATGRRTAARSPRTRREMAPALQRR GPSPPLNRRRSPPRPRQRWWSRPRVPGRPRRKSS RRRRRAPPTGRARPRKGPQRRATMTRNQRQTPP KAWPARQTRGRRSAACATSGSGRCRT*PGTCAP TQGKGHTNVRPASEPSP*STAWFATSGSTRKPGM PNTTGRTATRKSGVRRTARMSPPTAATTPSQRT RLSWLPMPATTWLSPGAGRRAWPVPPRTAATGR RRSRQGGRLSLARVTLTQRARRPWGRTCWSRAAR GLPTQSWPQLMAPPSSWGWSDSLSPPQHRQKPA EQSVYTSWGFLSALWLLRSERERERERERERER QAGAWLLAQCHSLTAACAGGHSPCRFQCLNYLPD PSILSWVLYFSKMTS*TKQIL**IVWRGPLHLS ISVILYWCV*ACSCESVIAPFVL*AGNRRKKHT LGYP*PITGRK*CEFHVNDQRKDG*DDNFLNRHF PFFFVLHGGAVIWSLVLQDVVDEGFQYGFRPKP GKILASASCPFPVCQH*TWSLFKFQDIHS*L*R RVTPLAS*PMENMHG*DIFDCLLFPFSICIINII IIIIIISSSVCCSLQ*AESNGQYLSWETCAAPR SPC*RVPAVVVGTLGW*LFYCNETSLSSVTAEF RRGREQSSQAWSRSSSERVE*GCMHPGNRHQEAR AVPGALQR*LWRKQSSDPVTRHITRERGIPSLP AKPNPSLTQLCYCHLQSKEILLLVIKLHMQDVR *EIGLYLPSCDVGLVLEDKCAVSSFLNSPHPWMQ KGRVIFTHEHPVQAIDFPHCLRLQGGECTPLHL SSWSLSQDLRGPQPACCWGPLCLLQCMEPLAFP WGGTPVPQLPSPGLFWPQCSSFT*TCSHRNVHAP FSPPLHQFLKSNLPDFTGR*IFLR**KVISSHT KGKKVEVYMIFNCIRGV*TSLKTRFYLL*R*MQ IRTNDPLAYLVKTSSYIP*

Sequence NM_001003698

ATGCCAGGGAGCCAAGCGTCCTGCCCGGCCGTTGCTCCGACTGTGTGTTCCAGGAGTGGTGGCTCTGAGGTGTGACCCTGCCCACGTTTGGGCCCAGCCA GGTTCAGCCCCCCAATAAGGAGGGCAGCTTGATAACACAAAGAAAACAGTGTCAACGAGTACTACCAAGAGAAGAAGACAAGAGGTCAACACAGACTCAT TTTCTACTCCGTGTGAATGATAGCTACAGCAGGGGAAAGTTTCATAGTCTATCAGTGGGTCAGAAAATGGAGTTTTATAGCAGAGGCTTCTTAGAAGCTT AAACCCCTGTCCCAATGACGTCAAGTTCGCCCGCTGGCTTGGAAGGTTCAGACCTATCTTCCATCAACACCATGATGTCGGCGGTCATGAGTGTAGGGAA GGTCACAGAGAATGGCGGGAGCCCCCAGGGGATCAAGTCCCCCTCGAAGCCTCCAGGACCAAATCGGATTGGCAGAAGGAACCAGGAAACGAAAGAGGAG AAGTCTTCCTATAACTGCCCCCTGTGTGAGAAGATTTGCACTACCCAGCACCAGCTGACCATGCACATTCGCCAGCACAACACAGACACTGGAGGAGCCG ACCACTCATGCAGCATCTGCGGAAAGTCACTGAGCTCGGCCAGCTCCCTCGATCGCCACATGCTGGTGCACTCTGGCGAGAGGCCTTACAAGTGCACTGT GTGTGGCCAGTCATTTACCACCAATGGGAACATGCACAGACATATGAAGATCCATGAGAAGGACCCTAACAGTGCCACAGCCACAGCCCCTCCATCTCCT CTGAAACGTAGGCGATTGTCCTCCAAGAGGAAACTGAGTCACGATGCCGAGTCAGAGAGAGAAGACCCAGCACCAGCTAAAAAGATGGTAGAAGACGGGC AGTCAGGTGACTTGGAGAAGAAAGCTGATGAAGTCTTTCACTGCCCAGTATGTTTCAAGGAGTTTGTTTGCAAGTATGGACTGGAGACCCACATGGAGAC CCATTCAGATAACCCACTAAGATGTGACATTTGTTGTGTCACCTTTCGAACACATCGAGGACTGCTGCGTCACAACGCGCTTGTCCACAAACAACTTCCC AGGGATGCAATGGGCAGACCTTTCATACAGAACAACCCTTCAATTCCTGCTGGCTTCCACGACTTAGGATTCACGGACTTCTCCTGTAGGAAGTTTCCTC GCATTTCTCAGGCCTGGTGCGAAACAAACCTGCGGAGGTGCATCAGCGAGCAACACCGTTTTGTCTGCGACACCTGTGACAAGGCGTTCCCCATGCTCTG CTCACTGGCTCTGCACAAGCAGACCCATGTGGCGGCAGACCAGGGTCAAGAAAAGCCGCAGGCCACGCCCCTGCCTGGTGACGCCCTGGACCAGAAGGGC TTCCTGGCCTTGCTTGGCCTGCAGCACACCAAAGACGTCAGGCCTGCCCCCGCCGAGGAGCCCCTGCCGGATGACAACCAGGCAATTCAGCTCCAGACAC TCAAGTGTCAGCTACCTCAGGACCCCGGCTGCACCAACCTGCTGAGCCTGTCACCTTTCGAAGCTGCTTCCCTAGGCGGTTCTCTCACAGTTCTCCCCGC GACCAAGGACAGCATAAAGCACCTGTCCCTGCAGCCCTTCCAGAAGGGCTTCATCATCCAGCCTGACAGCAGCATTGTGGTCAAGCCCATCTCTGGCGAG TCGGCCATCGAGCTGGCAGACATCCAGCAAATTCTGAAGATGGCAGCCTCGGCTCCCCCTCAGATCAGTCTTCCGCCCTTCTCCAAGGCCCCTGCCGCCC CACTGCAGGCGATCTTCAAGCACATGCCCCCTCTGAAGCCAAAGCCCCTGGTCACACCACGGACGGTGGTGGCCACCTCCACGCCCCCGCCTCTCATCAA CGCCCAGCAGGCTTCCCCGGGCTGTATCAGCCCCAGCCTGCCGCCACCGCCCCTGAAGCTCCTCAAAGGCTCAGTGGAGGCGGCCTCCAACGCCCACCTG CTGCAGTCCAAGTCCGGGACCCAGCCCCACGCGGCCACGCGGCTCTCCCTGCAGCAGCCGCGGGCGGAGCTGCCGGGCCAGCCTGAGATGAAGACGCAGC TGGAGCAGGACAGCATCATCGAGGCCCTGCTGCCGCTGAGCATGGAGGCCAAGATCAAGCAGGAGATCACAGAGGGGGAACTCAAGGCCTTCATGACAGC GCCCGGCGGCAAGAAGACGCCCGCCATGCGCAAGGTGCTCTACCCCTGCCGCTTCTGCAACCAGGTGTTTGCCTTCTCGGGGGTCTTGCGTGCCCACGTG CGCTCCCACCTGGGCATCTCGCCATACCAGTGCAACATCTGCGACTACATCGCCGCCGACAAGGCCGCGCTCATCCGCCACCTGCGCACGCACAGTGGGG AGCGGCCCTACATTTGCAAGATCTGCCACTACCCCTTCACTGTCAAAGCCAACTGCGAGCGGCACCTGCGCAAGAAGCACCTCAAGGCCACCCGCAAGGA TATCGAGAAGAACATCGAGTATGTGAGTAGCAGCGCGGCCGAGCTGGTGGACGCCTTCTGCGCCCCGGACACCGTGTGCCGGCTGTGCGGCGAGGACCTC AAGCACTATCGTGCCCTGCGCATCCACATGCGCACGCACTGCGGCCGCGGCCTGGGCGGGGGCCACAAGGGCCGCAAGCCCTTCGAGTGCAAGGAGTGCA GCGCCGCGTTCGCGGCCAAGCGCAACTGCATCCACCACATCCTCAAGCAGCACCTGCACGTGCCCGAGCAGGACATCGAGAGCTACGTGCTGGCCGCCGA CGGCCTGGGCCCCGCAGAGGCGCCGGCCGCTGAGGCGTCGGGGCGCGGGGAGGACAGTGGCTGCGCTGCCCTTGGTGACTGCAAGCCCCTCACTGCCTTC CTGGAACCCCAGAACGGCTTTCTTCACAGGGGCCCCACCCAGCCTCCACCTCCCCATGTCTCGATCAAGTTGGAGCCCGCCAGTAGCTTTGCGGTGGACT TCAATGAGCCCCTGGACTTCTCGCAGAAGGGCCTGGCCCTGGTCCAAGTGAAGCAGGAAAACATCTCCTTTCTGAGCCCTTCTTCCCTGGTCCCCTATGA CTGCTCCATGGAGCCCATCGACCTGTCCATCCCCAAGAACTTCAGGAAAGGGGACAAGGATTTGGCCACTCCCAGCGAAGCCAAGAAGCCTGAGGAGGAG GCGGGGAGCAGCGAGCAGCCCTCTCCCTGCCCAGCACCCGGCCCTTCTCTTCCTGTAACTTTGGGGCCCAGCGGAATCCTGGAAAGCCCCATGGCCCCTG CTCCGGCGGCCACCCCGGAACCCCCAGCACAGCCCCTGCAGGGCCCTGTTCAGCTGGCGGTCCCAATCTACTCCTCAGCCCTGGTCAGCAGCCCTCCACT CGTGGGCAGCTCAGCCCTCCTGAGTGGCACAGCCTTGCTGCGTCCACTGCGGCCCAAGCCCCCGCTGCTTTTGCCAAAGCCCCCCGTGACAGAAGAGCTG CCCCCGCTGGCCTCCATTGCCCAGATCATCTCATCTGTATCCTCGGCCCCCACCCTGCTGAAAACCAAGGTGGCGGACCCAGGGCCCGCAAGCACTGGCA GTAACACCACGGCTTCAGACAGCTTAGGAGGTTCTGTCCCCAAAGCCGCCACCACCGCCACCCCCGCTGCCACCACCAGCCCAAAAGAGTCTAGTGAGCC TCCCGCTCCAGCCAGCAGCCCAGAGGCTGCCTCTCCCACCGAGCAGGGCCCAGCGGGCACGTCGAAGAAGAGGGGCCGGAAAAGGGGGATGAGGAGCCGA CCCCGCGCCAACAGCGGCGGGGTGGACCTGGACTCCAGCGGGGAGTTTGCCAGCATCGAGAAGATGCTGGCCACCACAGACACCAACAAGTTCAGTCCGT TTCTGCAGACAGCGGAGGACAACACTCAGGATGAGGTGGCCGGAGCCCCTGCCGACCACCATGGGCCCAGTGATGAAGAGCAGGGCAGTCCCCCAGAAGA CAAGCTGCTGAGGGCCAAGCGGAACTCGTACACCAACTGCCTGCAGAAGATCACCTGTCCCCACTGTCCCCGGGTTTTCCCTTGGGCCAGCTCCCTACAG AGGCACATGCTCACACACACTGACAGTCAGTCGGATGCGGAGACTGCAGCCGCCGCGGGCGAAGTGCTAGACCTCACCTCACGGGACAGAGAGCAGCCGT CGGAGGGCGCCACTGAGCTCCGCCAGGTCGCAGGGGATGCGCCTGTGGAGCAGGCCACGGCGGAAACGGCCTCGCCGGTGCACCGGGAAGAGCACGGGCG TGGGGAGAGCCATGAGCCGGAGGAGGAGCATGGCACTGAGGAGAGCACTGGGGACGCCGACGGCGCGGAAGAGGACGCGTCGAGCAACCAGAGCCTGGAC CTGGACTTCGCCACCAAGCTCATGGACTTCAAGCTGGCGGAGGGCGACGGCGAGGCAGGCGCCGGGGGCGCGGCCTCGCAGGAGCAGAAGCTCGCCTGCG ACACCTGTGGGAAGAGCTTCAAGTTCCTGGGCACCCTGAGCCGCCACCGGAAGGCGCACGGCCGCCAGGAGCCCAAGGACGAGAAGGGAGATGGCGCCAG CACTGCAGAGGAGGGGCCCCAGCCCGCCCCTGAACAGGAGGAGAAGCCCCCCGAGACCCCGGCAGAGGTGGTGGAGTCGGCCCCGGGTGCCGGGGAGGCC CCGGCGGAAAAGCTCGCGGAGGAGACGGAGGGCCCCTCCGACGGGGAGAGCGCGGCCGAGAAAAGGTCCTCAGAGAAGAGCGACGATGACAAGAAACCAA AGACAGACTCCCCCAAAAGCGTGGCCAGCAAGGCAGACAAGAGGAAGAAGGTCTGCAGCGTGTGCAACAAGCGGTTCTGGTCGCTGCAGGACCTGACCCG GCACATGCGCTCCCACACAGGGGAAAGGCCATACAAATGTCAGACCTGCGAGCGAACCTTCACCTTGAAGCACAGCCTGGTTCGCCACCAGCGGATCCAC CAGAAAGCCAGGCATGCCAAACACCACGGGAAGGACAGCGACAAGGAAGAGCGGGGTGAGGAGGACAGCGAGAATGAGTCCACCCACAGCGGCAACAACG CCGTCTCAGAGAACGAGGCTGAGCTGGCTCCCAATGCCAGCAACCACATGGCTGTCACCCGGAGCCGGAAGGAGGGCTTGGCCAGTGCCACCAAGGACTG CAGCCACAGGGAGGAGAAGGTCACGGCAGGGTGGCCGTCTGAGCCTGGCCAGGGTGACCTTAACCCAGAGAGCCCGGCGGCCCTGGGGCAGGACCTGCTG GAGCCGCGCAGCAAGAGGCCTGCCCACCCAATCCTGGCCACAGCTGATGGCGCCTCCCAGCTCGTGGGGATGGAGTGACAGCCTCAGTCCCCCTCAGCAC AGACAAAAGCCAGCAGAGCAAAGCGTCTATACTTCATGGGGTTTCCTCAGTGCCCTTTGGCTGTTGAGGAGTGAGAGAGAGAGAGAGAGAGAGAGAGAGA GAGAGAGAGAGAGACAAGCAGGAGCGTGGCTGCTCGCTCAGTGCCATAGCCTTACCGCAGCCTGCGCGGGAGGCCACAGCCCGTGCCGATTCCAGTGCCT TAACTACTTACCGGATCCCTCCATATTATCATGGGTGTTGTATTTTTCCAAAATGACTTCTTAAACAAAACAAATATTATAATGAATTGTCTGGAGAGGA CCTCTTCATTTGAGCATTAGCGTTATTTTGTATTGGTGTGTGTGAGCTTGTTCTTGTGAATCTGTGATAGCACCGTTTGTTCTGTGAGCTGGAAACAGAA GGAAAAAACATACCCTTGGGTACCCATAGCCAATAACTGGAAGAAAATGATGTGAATTTCATGTAAATGACCAGAGGAAAGATGGATAAGATGATAATTT CTTAAATAGACATTTTCCTTTTTTCTTTGTGCTTCATGGTGGAGCTGTCATCTGGTCCTTGGTATTACAGGATGTGGTTGATGAAGGTTTCCAATATGGT TTCAGGCCAAAACCAGGGAAGATTCTAGCTTCAGCCTCATGTCCATTTCCAGTCTGTCAGCATTAGACATGGTCACTGTTCAAGTTTCAAGACATCCATT CTTAACTATAGAGAAGAGTTACTCCCCTGGCGTCTTAACCTATGGAAAACATGCACGGATAGGATATATTTGATTGCCTCCTCTTCCCTTTCAGTATATG TATTATTAATATTATTATTATTATTATTATTATTAGTTCATCAGTTTGCTGTTCTCTGCAGTGAGCAGAATCAAATGGGCAATATTTGTCCTGGGAGACC TGTGCCGCACCCAGGTCCCCGTGTTAACGTGTGCCTGCGGTTGTGGTTGGCACCCTCGGGTGGTAGCTCTTCTACTGTAATGAGACAAGCCTTTCTTCTG TCACTGCAGAATTTAGAAGGGGCCGTGAGCAGTCTTCCCAAGCATGGTCCAGGAGCAGCTCAGAGAGGGTGGAGTGAGGATGCATGCATCCAGGGAACAG GCATCAAGAAGCCAGGGCCGTGCCTGGAGCACTGCAGAGATGACTTTGGAGAAAGCAAAGCAGTGACCCAGTGACCAGGCACATTACTCGTGAGCGAGGT ATTCCCAGTCTTCCTGCTAAGCCTAATCCAAGCCTTACCCAGCTGTGCTACTGTCATTTGCAAAGCAAGGAAATACTACTACTGGTAATAAAACTACACA TGCAAGATGTCAGATAAGAAATAGGTTTATATTTACCTTCCTGCGATGTGGGGTTGGTGCTTGAAGATAAATGTGCTGTTTCTAGTTTCTTAAATAGCCC ACACCCCTGGATGCAAAAAGGCAGGGTTATTTTTACCCATGAGCATCCTGTGCAGGCAATAGACTTCCCTCACTGTCTCCGCCTGCAGGGAGGAGAATGT ACCCCACTGCACCTGAGCTCCTGGTCCCTCAGCCAAGACCTCAGGGGTCCCCAGCCAGCCTGCTGCTGGGGACCCCTGTGCTTGCTGCAGTGTATGGAGC CTCTTGCCTTCCCCTGGGGAGGCACCCCTGTACCCCAGCTTCCTTCCCCTGGCCTTTTCTGGCCCCAGTGCTCCTCCTTTACATAGACTTGTTCACACAG AAACGTGCACGCCCCCTTTTCTCCGCCACTTCACCAGTTTCTGAAATCCAACCTCCCAGACTTCACAGGAAGATAGATATTCTTGAGATAATGAAAAGTG ATATCTTCGCATACGAAAGGAAAAAAGGTTGAGGTATATATGATTTTTAACTGTATTAGGGGTGTATGAACCAGTTTAAAAACGAGGTTTTATTTACTGT AGAGATGAATGCAAATCAGAACCAATGATCCCTTGGCCTACTTAGTTAAAACCAGTTCATACATCCCTTAGG

refseq_RREB1.F1 (forward primer)
refseq_RREB1.R1 (reverse primer)
Single exon skipping

Frame 0

MPGSQASCPAVAPTVCSRSGGSEV*PCPRLGPA RFSPPIRRAA**HKENSVNEYYQEKKTRGQHRLI FYSV*MIATAGESFIVYQWVRKWSFIAEAS*KL KPLSQ*RQVRPLAWKVQTYLPSTP*CRRS*V*G RSQRMAGAPRGSSPPRSLQDQIGLAEGTRKRKRR SLPITAPCVRRFALPSTS*PCTFASTTQTLEEP TTHAASAESH*ARPAPSIATCWCTLARGLTSAL CVASHLPPMGTCTDI*RSMRRTLTVPQPQPLHLL *NVGDCPPRGN*VTMPSQREKTQHQLKRW*KTG SQVTWRRKLMKSFTAQYVSRSLFASMDWRPTWR PIQITH*DVTFVVSPFEHIEDCCVTTRLSTNNFP GMQWADLSYRTTLQFLLASTT*DSRTSPVGSFL AFLRPGAKQTCGGASASNTVLSATPVTRRSPCS AHWLCTSRPMWRQTRVKKSRRPRPCLVTPWTRRA SWPCLACSTPKTSGLPPPRSPCRMTTRQFSSRH SSVSYLRTPAAPTC*ACHLSKLLP*AVLSQFSP RPRTA*STCPCSPSRRASSSSLTAALWSSPSLAS RPSSWQTSSKF*RWQPRLPLRSVFRPSPRPLPP HCRRSSSTCPL*SQSPWSHHGRWWPPPRPRLSS TPSRLPRAVSAPACRHRP*SSSKAQWRRPPTPTC CSPSPGPSPTRPRGSPCSSRGRSCRASLR*RRS WSRTASSRPCCR*AWRPRSSRRSQRGNSRPS*Q RPAARRRPPCARCSTPAASATRCLPSRGSCVPTC APTWASRHTSATSATTSPPTRPRSSATCARTVG SGPTFARSATTPSLSKPTASGTCARSTSRPPAR ISRRTSSM*VAARPSWWTPSAPRTPCAGCAARTS STIVPCASTCARTAAAAWAGATRAASPSSARSA APRSRPSATASTTSSSSTCTCPSRTSRATCWPP TAWAPQRRRPLRRRGAGRTVAALPLVTASPSLPS WNPRTAFFTGAPPSLHLPMSRSSWSPPVALRWT SMSPWTSRRRAWPWSK*SRKTSPF*ALLPWSPM TAPWSPSTCPSPRTSGKGTRIWPLPAKPRSLRRR RGAASSPLPAQHPALLFL*LWGPAESWKAPWPL LRRPPRNPQHSPCRALFSWRSQSTPQPWSAALH SWAAQPS*VAQPCCVHCGPSPRCFCQSPP*QKSC PRWPPLPRSSHLYPRPPPC*KPRWRTQGPQALA VTPRLQTA*EVLSPKPPPPPPPLPPPAQKSLVS LPLQPAAQRLPLPPSRAQRARRRRGAGKGG*GAD PAPTAAGWTWTPAGSLPASRRCWPPQTPTSSVR FCRQRRTTLRMRWPEPLPTTMGPVMKSRAVPQK TSC*GPSGTRTPTACRRSPVPTVPGFSLGPAPYR GTCSHTLTVSRMRRLQPPRAKC*TSPHGTESSR RRAPLSSARSQGMRLWSRPRRKRPRRCTGKSTG VGRAMSRRRSMALRRALGTPTARKRTRRATRAWT WTSPPSSWTSSWRRATARQAPGARPRRSRSSPA TPVGRASSSWAP*AATGRRTAARSPRTRREMAP ALQRRGPSPPLNRRRSPPRPRQRWWSRPRVPGRP RRKSSRRRRRAPPTGRARPRKGPQRRATMTRNQ RQTPPKAWPARQTRGRRSAACATSGSGRCRT*P GTCAPTQGKGHTNVRPASEPSP*STAWFATSGST RKPGMPNTTGRTATRKSGVRRTARMSPPTAATT PSQRTRLSWLPMPATTWLSPGAGRRAWPVPPRT AATGRRRSRQGGRLSLARVTLTQRARRPWGRTCW SRAARGLPTQSWPQLMAPPSSWGWSDSLSPPQH RQKPAEQSVYTSWGFLSALWLLRSERERERERE RERERQAGAWLLAQCHSLTAACAGGHSPCRFQCL NYLPDPSILSWVLYFSKMTS*TKQIL**IVWRG PLHLSISVILYWCV*ACSCESVIAPFVL*AGNR RKKHTLGYP*PITGRK*CEFHVNDQRKDG*DDNF LNRHFPFFFVLHGGAVIWSLVLQDVVDEGFQYG FRPKPGKILASASCPFPVCQH*TWSLFKFQDIH S*L*RRVTPLAS*PMENMHG*DIFDCLLFPFSIC IINIIIIIIIISSSVCCSLQ*AESNGQYLSWET CAAPRSPC*RVPAVVVGTLGW*LFYCNETSLSS VTAEFRRGREQSSQAWSRSSSERVE*GCMHPGNR HQEARAVPGALQR*LWRKQSSDPVTRHITRERG IPSLPAKPNPSLTQLCYCHLQSKEILLLVIKLH MQDVR*EIGLYLPSCDVGLVLEDKCAVSSFLNSP HPWMQKGRVIFTHEHPVQAIDFPHCLRLQGGEC TPLHLSSWSLSQDLRGPQPACCWGPLCLLQCME PLAFPWGGTPVPQLPSPGLFWPQCSSFT*TCSHR NVHAPFSPPLHQFLKSNLPDFTGR*IFLR**KV ISSHTKGKKVEVYMIFNCIRGV*TSLKTRFYLL *R*MQIRTNDPLAYLVKTSSYIP*

Frame 1

CQGAKRPARPLLRLCVPGVVALRCDPAHVWAQP GSAPQ*GGQLDNTKKTVSTSTTKRRRQEVNTDS FSTPCE**LQQGKVS*SISGSENGVL*QRLLRSL NPCPNDVKFARWLGRFRPIFHQHHDVGGHECRE GHREWREPPGDQVPLEASRTKSDWQKEPGNERG EVFL*LPPV*EDLHYPAPADHAHSPAQHRHWRSR PLMQHLRKVTELGQLPRSPHAGALWREALQVHC VWPVIYHQWEHAQTYEDP*EGP*QCHSHSPSIS SET*AIVLQEETESRCRVRERRPSTS*KDGRRRA VR*LGEES**SLSLPSMFQGVCLQVWTGDPHGD PFR*PTKM*HLLCHLSNTSRTAASQRACPQTTS QGCNGQTFHTEQPFNSCWLPRLRIHGLLL*EVSS HFSGLVRNKPAEVHQRATPFCLRHL*QGVPHAL LTGSAQADPCGGRPGSRKAAGHAPAW*RPGPEG LPGLAWPAAHQRRQACPRRGAPAG*QPGNSAPDT QVSATSGPRLHQPAEPVTFRSCFPRRFSHSSPR DQGQHKAPVPAALPEGLHHPA*QQHCGQAHLWR VGHRAGRHPANSEDGSLGSPSDQSSALLQGPCRP TAGDLQAHAPSEAKAPGHTTDGGGHLHAPASHQ RPAGFPGLYQPQPAATAPEAPQRLSGGGLQRPP AAVQVRDPAPRGHAALPAAAAGGAAGPA*DEDAA GAGQHHRGPAAAEHGGQDQAGDHRGGTQGLHDS ARRQEDARHAQGALPLPLLQPGVCLLGGLACPR ALPPGHLAIPVQHLRLHRRRQGRAHPPPAHAQWG AALHLQDLPLPLHCQSQLRAAPAQEAPQGHPQG YREEHRVCE*QRGRAGGRLLRPGHRVPAVRRGP QALSCPAHPHAHALRPRPGRGPQGPQALRVQGVQ RRVRGQAQLHPPHPQAAPARARAGHRELRAGRR RPGPRRGAGR*GVGARGGQWLRCPW*LQAPHCL PGTPERLSSQGPHPASTSPCLDQVGARQ*LCGGL Q*APGLLAEGPGPGPSEAGKHLLSEPFFPGPL* LLHGAHRPVHPQELQERGQGFGHSQRSQEA*GG GGEQRAALSLPSTRPFSSCNFGAQRNPGKPHGPC SGGHPGTPSTAPAGPCSAGGPNLLLSPGQQPST RGQLSPPEWHSLAASTAAQAPAAFAKAPRDRRA APAGLHCPDHLICILGPHPAENQGGGPRARKHWQ *HHGFRQLRRFCPQSRHHRHPRCHHQPKRV**A SRSSQQPRGCLSHRAGPSGHVEEEGPEKGDEEP TPRQQRRGGPGLQRGVCQHREDAGHHRHQQVQSV SADSGGQHSG*GGRSPCRPPWAQ**RAGQSPRR QAAEGQAELVHQLPAEDHLSPLSPGFPLGQLPT EAHAHTH*QSVGCGDCSRRGRSARPHLTGQRAAV GGRH*APPGRRGCACGAGHGGNGLAGAPGRARA WGEP*AGGGAWH*GEHWGRRRRGRGRVEQPEPG PGLRHQAHGLQAGGGRRRGRRRGRGLAGAEARLR HLWEELQVPGHPEPPPEGARPPGAQGREGRWRQ HCRGGAPARP*TGGEAPRDPGRGGGVGPGCRGG PGGKARGGDGGPLRRGERGREKVLREERR*QETK DRLPQKRGQQGRQEEEGLQRVQQAVLVAAGPDP AHALPHRGKAIQMSDLRANLHLEAQPGSPPADP PESQACQTPREGQRQGRAG*GGQRE*VHPQRQQR RLRERG*AGSQCQQPHGCHPEPEGGLGQCHQGL QPQGGEGHGRVAV*AWPG*P*PREPGGPGAGPA GAAQQEACPPNPGHS*WRLPARGDGVTASVPLST DKSQQSKASILHGVSSVPFGC*GVRERERERER ERERDKQERGCSLSAIALPQPAREATARADSSA LTTYRIPPYYHGCCIFPK*LLKQNKYYNELSGED LFI*ALALFCIGVCELVLVNL**HRLFCELETE GKNIPLGTHSQ*LEENDVNFM*MTRGKMDKMII S*IDIFLFSLCFMVELSSGPWYYRMWLMKVSNMV SGQNQGRF*LQPHVHFQSVSIRHGHCSSFKTSI LNYREELLPWRLNLWKTCTDRIYLIASSSLSVY VLLILLLLLLLLVHQFAVLCSEQNQMGNICPGRP VPHPGPRVNVCLRLWLAPSGGSSSTVMRQAFLL SLQNLEGAVSSLPKHGPGAAQRGWSEDACIQGT GIKKPGPCLEHCRDDFGESKAVTQ*PGTLLVSEV FPVFLLSLIQALPSCATVICKARKYYYW**NYT CKMSDKK*VYIYLPAMWGWCLKINVLFLVS*IA HTPGCKKAGLFLPMSILCRQ*TSLTVSACREENV PHCT*APGPSAKTSGVPSQPAAGDPCACCSVWS LLPSPGEAPLYPSFLPLAFSGPSAPPLHRLVHT ETCTPPFLRHFTSF*NPTSQTSQEDRYS*DNEK* YLRIRKEKRLRYI*FLTVLGVYEPV*KRGFIYC RDECKSEPMIPWPT*LKPVHTSLR

Frame 2

AREPSVLPGRCSDCVFQEWWL*GVTLPTFGPSQ VQPPNKEGSLITQRKQCQRVLPREEDKRSTQTH FLLRVNDSYSRGKFHSLSVGQKMEFYSRGFLEA *TPVPMTSSSPAGLEGSDLSSINTMMSAVMSVGK VTENGGSPQGIKSPSKPPGPNRIGRRNQETKEE KSSYNCPLCEKICTTQHQLTMHIRQHNTDTGGA DHSCSICGKSLSSASSLDRHMLVHSGERPYKCTV CGQSFTTNGNMHRHMKIHEKDPNSATATAPPSP LKRRRLSSKRKLSHDAESEREDPAPAKKMVEDG QSGDLEKKADEVFHCPVCFKEFVCKYGLETHMET HSDNPLRCDICCVTFRTHRGLLRHNALVHKQLP RDAMGRPFIQNNPSIPAGFHDLGFTDFSCRKFP RISQAWCETNLRRCISEQHRFVCDTCDKAFPMLC SLALHKQTHVAADQGQEKPQATPLPGDALDQKG FLALLGLQHTKDVRPAPAEEPLPDDNQAIQLQT LKCQLPQDPGCTNLLSLSPFEAASLGGSLTVLPA TKDSIKHLSLQPFQKGFIIQPDSSIVVKPISGE SAIELADIQQILKMAASAPPQISLPPFSKAPAA PLQAIFKHMPPLKPKPLVTPRTVVATSTPPPLIN AQQASPGCISPSLPPPPLKLLKGSVEAASNAHL LQSKSGTQPHAATRLSLQQPRAELPGQPEMKTQ LEQDSIIEALLPLSMEAKIKQEITEGELKAFMTA PGGKKTPAMRKVLYPCRFCNQVFAFSGVLRAHV RSHLGISPYQCNICDYIAADKAALIRHLRTHSG ERPYICKICHYPFTVKANCERHLRKKHLKATRKD IEKNIEYVSSSAAELVDAFCAPDTVCRLCGEDL KHYRALRIHMRTHCGRGLGGGHKGRKPFECKEC SAAFAAKRNCIHHILKQHLHVPEQDIESYVLAAD GLGPAEAPAAEASGRGEDSGCAALGDCKPLTAF LEPQNGFLHRGPTQPPPPHVSIKLEPASSFAVD FNEPLDFSQKGLALVQVKQENISFLSPSSLVPYD CSMEPIDLSIPKNFRKGDKDLATPSEAKKPEEE AGSSEQPSPCPAPGPSLPVTLGPSGILESPMAP APAATPEPPAQPLQGPVQLAVPIYSSALVSSPPL VGSSALLSGTALLRPLRPKPPLLLPKPPVTEEL PPLASIAQIISSVSSAPTLLKTKVADPGPASTG SNTTASDSLGGSVPKAATTATPAATTSPKESSEP PAPASSPEAASPTEQGPAGTSKKRGRKRGMRSR PRANSGGVDLDSSGEFASIEKMLATTDTNKFSP FLQTAEDNTQDEVAGAPADHHGPSDEEQGSPPED KLLRAKRNSYTNCLQKITCPHCPRVFPWASSLQ RHMLTHTDSQSDAETAAAAGEVLDLTSRDREQP SEGATELRQVAGDAPVEQATAETASPVHREEHGR GESHEPEEEHGTEESTGDADGAEEDASSNQSLD LDFATKLMDFKLAEGDGEAGAGGAASQEQKLAC DTCGKSFKFLGTLSRHRKAHGRQEPKDEKGDGAS TAEEGPQPAPEQEEKPPETPAEVVESAPGAGEA PAEKLAEETEGPSDGESAAEKRSSEKSDDDKKP KTDSPKSVASKADKRKKVCSVCNKRFWSLQDLTR HMRSHTGERPYKCQTCERTFTLKHSLVRHQRIH QKARHAKHHGKDSDKEERGEEDSENESTHSGNN AVSENEAELAPNASNHMAVTRSRKEGLASATKDC SHREEKVTAGWPSEPGQGDLNPESPAALGQDLL EPRSKRPAHPILATADGASQLVGME*QPQSPSA QTKASRAKRLYFMGFPQCPLAVEE*ERERERERE RERETSRSVAARSVP*PYRSLRGRPQPVPIPVP *LLTGSLHIIMGVVFFQNDFLNKTNIIMNCLER TSSFEH*RYFVLVCVSLFL*ICDSTVCSVSWKQK EKTYPWVPIANNWKKMM*ISCK*PEERWIR**F LK*TFSFFLCASWWSCHLVLGITGCG**RFPIW FQAKTREDSSFSLMSISSLSALDMVTVQVSRHPF LTIEKSYSPGVLTYGKHARIGYI*LPPLPFQYM YY*YYYYYYYY*FISLLFSAVSRIKWAIFVLGD LCRTQVPVLTCACGCGWHPRVVALLL**DKPFFC HCRI*KGP*AVFPSMVQEQLREGGVRMHASREQ ASRSQGRAWSTAEMTLEKAKQ*PSDQAHYS*AR YSQSSC*A*SKPYPAVLLSFAKQGNTTTGNKTTH ARCQIRNRFIFTFLRCGVGA*R*MCCF*FLK*P TPLDAKRQGYFYP*ASCAGNRLPSLSPPAGRRM YPTAPELLVPQPRPQGSPASLLLGTPVLAAVYGA SCLPLGRHPCTPASFPWPFLAPVLLLYIDLFTQ KRARPLFSATSPVSEIQPPRLHRKIDILEIMKS DIFAYERKKG*GIYDF*LY*GCMNQFKNEVLFTV EMNANQNQ*SLGLLS*NQFIHPL

Sequence NM_001003699

ATGCCAGGGAGCCAAGCGTCCTGCCCGGCCGTTGCTCCGACTGTGTGTTCCAGGAGTGGTGGCTCTGAGGTGTGACCCTGCCCACGTTTGGGCCCAGCCA GGTTCAGCCCCCCAATAAGGAGGGCAGCTTGATAACACAAAGAAAACAGTGTCAACGAGTACTACCAAGAGAAGAAGACAAGAGGTCAACACAGACTCAT TTTCTACTCCGTGTGAATGATAGCTACAGCAGGGGAAAGTTTCATAGTCTATCAGTGGGTCAGAAAATGGAGTTTTATAGCAGAGGCTTCTTAGAAGCTT AAACCCCTGTCCCAATGACGTCAAGTTCGCCCGCTGGCTTGGAAGGTTCAGACCTATCTTCCATCAACACCATGATGTCGGCGGTCATGAGTGTAGGGAA GGTCACAGAGAATGGCGGGAGCCCCCAGGGGATCAAGTCCCCCTCGAAGCCTCCAGGACCAAATCGGATTGGCAGAAGGAACCAGGAAACGAAAGAGGAG AAGTCTTCCTATAACTGCCCCCTGTGTGAGAAGATTTGCACTACCCAGCACCAGCTGACCATGCACATTCGCCAGCACAACACAGACACTGGAGGAGCCG ACCACTCATGCAGCATCTGCGGAAAGTCACTGAGCTCGGCCAGCTCCCTCGATCGCCACATGCTGGTGCACTCTGGCGAGAGGCCTTACAAGTGCACTGT GTGTGGCCAGTCATTTACCACCAATGGGAACATGCACAGACATATGAAGATCCATGAGAAGGACCCTAACAGTGCCACAGCCACAGCCCCTCCATCTCCT CTGAAACGTAGGCGATTGTCCTCCAAGAGGAAACTGAGTCACGATGCCGAGTCAGAGAGAGAAGACCCAGCACCAGCTAAAAAGATGGTAGAAGACGGGC AGTCAGGTGACTTGGAGAAGAAAGCTGATGAAGTCTTTCACTGCCCAGTATGTTTCAAGGAGTTTGTTTGCAAGTATGGACTGGAGACCCACATGGAGAC CCATTCAGATAACCCACTAAGATGTGACATTTGTTGTGTCACCTTTCGAACACATCGAGGACTGCTGCGTCACAACGCGCTTGTCCACAAACAACTTCCC AGGGATGCAATGGGCAGACCTTTCATACAGAACAACCCTTCAATTCCTGCTGGCTTCCACGACTTAGGATTCACGGACTTCTCCTGTAGGAAGTTTCCTC GCATTTCTCAGGCCTGGTGCGAAACAAACCTGCGGAGGTGCATCAGCGAGCAACACCGTTTTGTCTGCGACACCTGTGACAAGGCGTTCCCCATGCTCTG CTCACTGGCTCTGCACAAGCAGACCCATGTGGCGGCAGACCAGGGTCAAGAAAAGCCGCAGGCCACGCCCCTGCCTGGTGACGCCCTGGACCAGAAGGGC TTCCTGGCCTTGCTTGGCCTGCAGCACACCAAAGACGTCAGGCCTGCCCCCGCCGAGGAGCCCCTGCCGGATGACAACCAGGCAATTCAGCTCCAGACAC TCAAGTGTCAGCTACCTCAGGACCCCGGCTGCACCAACCTGCTGAGCCTGTCACCTTTCGAAGCTGCTTCCCTAGGCGGTTCTCTCACAGTTCTCCCCGC GACCAAGGACAGCATAAAGCACCTGTCCCTGCAGCCCTTCCAGAAGGGCTTCATCATCCAGCCTGACAGCAGCATTGTGGTCAAGCCCATCTCTGGCGAG TCGGCCATCGAGCTGGCAGACATCCAGCAAATTCTGAAGATGGCAGCCTCGGCTCCCCCTCAGATCAGTCTTCCGCCCTTCTCCAAGGCCCCTGCCGCCC CACTGCAGGCGATCTTCAAGCACATGCCCCCTCTGAAGCCAAAGCCCCTGGTCACACCACGGACGGTGGTGGCCACCTCCACGCCCCCGCCTCTCATCAA CGCCCAGCAGGCTTCCCCGGGCTGTATCAGCCCCAGCCTGCCGCCACCGCCCCTGAAGCTCCTCAAAGGCTCAGTGGAGGCGGCCTCCAACGCCCACCTG CTGCAGTCCAAGTCCGGGACCCAGCCCCACGCGGCCACGCGGCTCTCCCTGCAGCAGCCGCGGGCGGAGCTGCCGGGCCAGCCTGAGATGAAGACGCAGC TGGAGCAGGACAGCATCATCGAGGCCCTGCTGCCGCTGAGCATGGAGGCCAAGATCAAGCAGGAGATCACAGAGGGGGAACTCAAGGCCTTCATGACAGC GCCCGGCGGCAAGAAGACGCCCGCCATGCGCAAGGTGCTCTACCCCTGCCGCTTCTGCAACCAGGTGTTTGCCTTCTCGGGGGTCTTGCGTGCCCACGTG CGCTCCCACCTGGGCATCTCGCCATACCAGTGCAACATCTGCGACTACATCGCCGCCGACAAGGCCGCGCTCATCCGCCACCTGCGCACGCACAGTGGGG AGCGGCCCTACATTTGCAAGATCTGCCACTACCCCTTCACTGTCAAAGCCAACTGCGAGCGGCACCTGCGCAAGAAGCACCTCAAGGCCACCCGCAAGGA TATCGAGAAGAACATCGAGTATGTGAGTAGCAGCGCGGCCGAGCTGGTGGACGCCTTCTGCGCCCCGGACACCGTGTGCCGGCTGTGCGGCGAGGACCTC AAGCACTATCGTGCCCTGCGCATCCACATGCGCACGCACTGCGGCCGCGGCCTGGGCGGGGGCCACAAGGGCCGCAAGCCCTTCGAGTGCAAGGAGTGCA GCGCCGCGTTCGCGGCCAAGCGCAACTGCATCCACCACATCCTCAAGCAGCACCTGCACGTGCCCGAGCAGGACATCGAGAGCTACGTGCTGGCCGCCGA CGGCCTGGGCCCCGCAGAGGCGCCGGCCGCTGAGGCGTCGGGGCGCGGGGAGGACAGTGGCTGCGCTGCCCTTGGTGACTGCAAGCCCCTCACTGCCTTC CTGGAACCCCAGAACGGCTTTCTTCACAGGGGCCCCACCCAGCCTCCACCTCCCCATGTCTCGATCAAGTTGGAGCCCGCCAGTAGCTTTGCGGTGGACT TCAATGAGCCCCTGGACTTCTCGCAGAAGGGCCTGGCCCTGGTCCAAGTGAAGCAGGAAAACATCTCCTTTCTGAGCCCTTCTTCCCTGGTCCCCTATGA CTGCTCCATGGAGCCCATCGACCTGTCCATCCCCAAGAACTTCAGGAAAGGGGACAAGGATTTGGCCACTCCCAGCGAAGCCAAGAAGCCTGAGGAGGAG GCGGGGAGCAGCGAGCAGCCCTCTCCCTGCCCAGCACCCGGCCCTTCTCTTCCTGTAACTTTGGGGCCCAGCGGAATCCTGGAAAGCCCCATGGCCCCTG CTCCGGCGGCCACCCCGGAACCCCCAGCACAGCCCCTGCAGGGCCCTGTTCAGCTGGCGGTCCCAATCTACTCCTCAGCCCTGGTCAGCAGCCCTCCACT CGTGGGCAGCTCAGCCCTCCTGAGTGGCACAGCCTTGCTGCGTCCACTGCGGCCCAAGCCCCCGCTGCTTTTGCCAAAGCCCCCCGTGACAGAAGAGCTG CCCCCGCTGGCCTCCATTGCCCAGATCATCTCATCTGTATCCTCGGCCCCCACCCTGCTGAAAACCAAGGTGGCGGACCCAGGGCCCGCAAGCACTGGCA GTAACACCACGGCTTCAGACAGCTTAGGAGGTTCTGTCCCCAAAGCCGCCACCACCGCCACCCCCGCTGCCACCACCAGCCCAAAAGAGTCTAGTGAGCC TCCCGCTCCAGCCAGCAGCCCAGAGGCTGCCTCTCCCACCGAGCAGGGCCCAGCGGGCACGTCGAAGAAGAGGGGCCGGAAAAGGGGGATGAGGAGCCGA CCCCGCGCCAACAGCGGCGGGGTGGACCTGGACTCCAGCGGGGAGTTTGCCAGCATCGAGAAGATGCTGGCCACCACAGACACCAACAAGTTCAGTCCGT TTCTGCAGACAGCGGAGGACAACACTCAGGATGAGGTGGCCGGAGCCCCTGCCGACCACCATGGGCCCAGTGATGAAGAGCAGGGCAGTCCCCCAGAAGA CAAGCTGCTGAGGGCCAAGCGGAACTCGTACACCAACTGCCTGCAGAAGATCACCTGTCCCCACTGTCCCCGGGTTTTCCCTTGGGCCAGCTCCCTACAG AGGCACATGCTCACACACACTGGTCAGAAACCCTTCCCTTGTCAAAAATGCGATGCCTTCTTTTCTACCAAATCTAACTGTGAACGCCACCAGTTGCGCA AACACGGAGTTACCACCTGTTCCCTGAGAAGAAACGGGCTTATCCCCCAGTCAAAAGAGAGTGATGTTGGATCCCATGATAGCACAGACAGTCAGTCGGA TGCGGAGACTGCAGCCGCCGCGGGCGAAGTGCTAGACCTCACCTCACGGGACAGAGAGCAGCCGTCGGAGGGCGCCACTGAGCTCCGCCAGGTCGCAGGG GATGCGCCTGTGGAGCAGGCCACGGCGGAAACGGCCTCGCCGGTGCACCGGGAAGAGCACGGGCGTGGGGAGAGCCATGAGCCGGAGGAGGAGCATGGCA CTGAGGAGAGCACTGGGGACGCCGACGGCGCGGAAGAGGACGCGTCGAGCAACCAGAGCCTGGACCTGGACTTCGCCACCAAGCTCATGGACTTCAAGCT GGCGGAGGGCGACGGCGAGGCAGGCGCCGGGGGCGCGGCCTCGCAGGAGCAGAAGCTCGCCTGCGACACCTGTGGGAAGAGCTTCAAGTTCCTGGGCACC CTGAGCCGCCACCGGAAGGCGCACGGCCGCCAGGAGCCCAAGGACGAGAAGGGAGATGGCGCCAGCACTGCAGAGGAGGGGCCCCAGCCCGCCCCTGAAC AGGAGGAGAAGCCCCCCGAGACCCCGGCAGAGGTGGTGGAGTCGGCCCCGGGTGCCGGGGAGGCCCCGGCGGAAAAGCTCGCGGAGGAGACGGAGGGCCC CTCCGACGGGGAGAGCGCGGCCGAGAAAAGGTCCTCAGAGAAGAGCGACGATGACAAGAAACCAAAGACAGACTCCCCCAAAAGCGTGGCCAGCAAGGCA GACAAGAGGAAGAAGGTCTGCAGCGTGTGCAACAAGCGGTTCTGGTCGCTGCAGGACCTGACCCGGCACATGCGCTCCCACACAGGGGAAAGGCCATACA AATGTCAGACCTGCGAGCGAACCTTCACCTTGAAGCACAGCCTGGTTCGCCACCAGCGGATCCACCAGAAAGCCAGGCATGCCAAACACCACGGGAAGGA CAGCGACAAGGAAGAGCGGGGTGAGGAGGACAGCGAGAATGAGTCCACCCACAGCGGCAACAACGCCGTCTCAGAGAACGAGGCTGAGCTGGCTCCCAAT GCCAGCAACCACATGGCTGTCACCCGGAGCCGGAAGGAGGGCTTGGCCAGTGCCACCAAGGACTGCAGCCACAGGGAGGAGAAGGTCACGGCAGGGTGGC CGTCTGAGCCTGGCCAGGGTGACCTTAACCCAGAGAGCCCGGCGGCCCTGGGGCAGGACCTGCTGGAGCCGCGCAGCAAGAGGCCTGCCCACCCAATCCT GGCCACAGCTGATGGCGCCTCCCAGCTCGTGGGGATGGAGTGACAGCCTCAGTCCCCCTCAGCACAGACAAAAGCCAGCAGAGCAAAGCGTCTATACTTC ATGGGGTTTCCTCAGTGCCCTTTGGCTGTTGAGGAGTGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGACAAGCAGGAGCGTGGCTGCTC GCTCAGTGCCATAGCCTTACCGCAGCCTGCGCGGGAGGCCACAGCCCGTGCCGATTCCAGTGCCTTAACTACTTACCGGATCCCTCCATATTATCATGGG TGTTGTATTTTTCCAAAATGACTTCTTAAACAAAACAAATATTATAATGAATTGTCTGGAGAGGACCTCTTCATTTGAGCATTAGCGTTATTTTGTATTG GTGTGTGTGAGCTTGTTCTTGTGAATCTGTGATAGCACCGTTTGTTCTGTGAGCTGGAAACAGAAGGAAAAAACATACCCTTGGGTACCCATAGCCAATA ACTGGAAGAAAATGATGTGAATTTCATGTAAATGACCAGAGGAAAGATGGATAAGATGATAATTTCTTAAATAGACATTTTCCTTTTTTCTTTGTGCTTC ATGGTGGAGCTGTCATCTGGTCCTTGGTATTACAGGATGTGGTTGATGAAGGTTTCCAATATGGTTTCAGGCCAAAACCAGGGAAGATTCTAGCTTCAGC CTCATGTCCATTTCCAGTCTGTCAGCATTAGACATGGTCACTGTTCAAGTTTCAAGACATCCATTCTTAACTATAGAGAAGAGTTACTCCCCTGGCGTCT TAACCTATGGAAAACATGCACGGATAGGATATATTTGATTGCCTCCTCTTCCCTTTCAGTATATGTATTATTAATATTATTATTATTATTATTATTATTA GTTCATCAGTTTGCTGTTCTCTGCAGTGAGCAGAATCAAATGGGCAATATTTGTCCTGGGAGACCTGTGCCGCACCCAGGTCCCCGTGTTAACGTGTGCC TGCGGTTGTGGTTGGCACCCTCGGGTGGTAGCTCTTCTACTGTAATGAGACAAGCCTTTCTTCTGTCACTGCAGAATTTAGAAGGGGCCGTGAGCAGTCT TCCCAAGCATGGTCCAGGAGCAGCTCAGAGAGGGTGGAGTGAGGATGCATGCATCCAGGGAACAGGCATCAAGAAGCCAGGGCCGTGCCTGGAGCACTGC AGAGATGACTTTGGAGAAAGCAAAGCAGTGACCCAGTGACCAGGCACATTACTCGTGAGCGAGGTATTCCCAGTCTTCCTGCTAAGCCTAATCCAAGCCT TACCCAGCTGTGCTACTGTCATTTGCAAAGCAAGGAAATACTACTACTGGTAATAAAACTACACATGCAAGATGTCAGATAAGAAATAGGTTTATATTTA CCTTCCTGCGATGTGGGGTTGGTGCTTGAAGATAAATGTGCTGTTTCTAGTTTCTTAAATAGCCCACACCCCTGGATGCAAAAAGGCAGGGTTATTTTTA CCCATGAGCATCCTGTGCAGGCAATAGACTTCCCTCACTGTCTCCGCCTGCAGGGAGGAGAATGTACCCCACTGCACCTGAGCTCCTGGTCCCTCAGCCA AGACCTCAGGGGTCCCCAGCCAGCCTGCTGCTGGGGACCCCTGTGCTTGCTGCAGTGTATGGAGCCTCTTGCCTTCCCCTGGGGAGGCACCCCTGTACCC CAGCTTCCTTCCCCTGGCCTTTTCTGGCCCCAGTGCTCCTCCTTTACATAGACTTGTTCACACAGAAACGTGCACGCCCCCTTTTCTCCGCCACTTCACC AGTTTCTGAAATCCAACCTCCCAGACTTCACAGGAAGATAGATATTCTTGAGATAATGAAAAGTGATATCTTCGCATACGAAAGGAAAAAAGGTTGAGGT ATATATGATTTTTAACTGTATTAGGGGTGTATGAACCAGTTTAAAAACGAGGTTTTATTTACTGTAGAGATGAATGCAAATCAGAACCAATGATCCCTTG GCCTACTTAGTTAAAACCAGTTCATACATCCCTTAGG

refseq_RREB1.F1 (forward primer)
refseq_RREB1.R1 (reverse primer)
Single exon skipping

Frame 0

MPGSQASCPAVAPTVCSRSGGSEV*PCPRLGPA RFSPPIRRAA**HKENSVNEYYQEKKTRGQHRLI FYSV*MIATAGESFIVYQWVRKWSFIAEAS*KL KPLSQ*RQVRPLAWKVQTYLPSTP*CRRS*V*G RSQRMAGAPRGSSPPRSLQDQIGLAEGTRKRKRR SLPITAPCVRRFALPSTS*PCTFASTTQTLEEP TTHAASAESH*ARPAPSIATCWCTLARGLTSAL CVASHLPPMGTCTDI*RSMRRTLTVPQPQPLHLL *NVGDCPPRGN*VTMPSQREKTQHQLKRW*KTG SQVTWRRKLMKSFTAQYVSRSLFASMDWRPTWR PIQITH*DVTFVVSPFEHIEDCCVTTRLSTNNFP GMQWADLSYRTTLQFLLASTT*DSRTSPVGSFL AFLRPGAKQTCGGASASNTVLSATPVTRRSPCS AHWLCTSRPMWRQTRVKKSRRPRPCLVTPWTRRA SWPCLACSTPKTSGLPPPRSPCRMTTRQFSSRH SSVSYLRTPAAPTC*ACHLSKLLP*AVLSQFSP RPRTA*STCPCSPSRRASSSSLTAALWSSPSLAS RPSSWQTSSKF*RWQPRLPLRSVFRPSPRPLPP HCRRSSSTCPL*SQSPWSHHGRWWPPPRPRLSS TPSRLPRAVSAPACRHRP*SSSKAQWRRPPTPTC CSPSPGPSPTRPRGSPCSSRGRSCRASLR*RRS WSRTASSRPCCR*AWRPRSSRRSQRGNSRPS*Q RPAARRRPPCARCSTPAASATRCLPSRGSCVPTC APTWASRHTSATSATTSPPTRPRSSATCARTVG SGPTFARSATTPSLSKPTASGTCARSTSRPPAR ISRRTSSM*VAARPSWWTPSAPRTPCAGCAARTS STIVPCASTCARTAAAAWAGATRAASPSSARSA APRSRPSATASTTSSSSTCTCPSRTSRATCWPP TAWAPQRRRPLRRRGAGRTVAALPLVTASPSLPS WNPRTAFFTGAPPSLHLPMSRSSWSPPVALRWT SMSPWTSRRRAWPWSK*SRKTSPF*ALLPWSPM TAPWSPSTCPSPRTSGKGTRIWPLPAKPRSLRRR RGAASSPLPAQHPALLFL*LWGPAESWKAPWPL LRRPPRNPQHSPCRALFSWRSQSTPQPWSAALH SWAAQPS*VAQPCCVHCGPSPRCFCQSPP*QKSC PRWPPLPRSSHLYPRPPPC*KPRWRTQGPQALA VTPRLQTA*EVLSPKPPPPPPPLPPPAQKSLVS LPLQPAAQRLPLPPSRAQRARRRRGAGKGG*GAD PAPTAAGWTWTPAGSLPASRRCWPPQTPTSSVR FCRQRRTTLRMRWPEPLPTTMGPVMKSRAVPQK TSC*GPSGTRTPTACRRSPVPTVPGFSLGPAPYR GTCSHTLVRNPSLVKNAMPSFLPNLTVNATSCA NTELPPVP*EETGLSPSQKRVMLDPMIAQTVSR MRRLQPPRAKC*TSPHGTESSRRRAPLSSARSQG MRLWSRPRRKRPRRCTGKSTGVGRAMSRRRSMA LRRALGTPTARKRTRRATRAWTWTSPPSSWTSS WRRATARQAPGARPRRSRSSPATPVGRASSSWAP *AATGRRTAARSPRTRREMAPALQRRGPSPPLN RRRSPPRPRQRWWSRPRVPGRPRRKSSRRRRRA PPTGRARPRKGPQRRATMTRNQRQTPPKAWPARQ TRGRRSAACATSGSGRCRT*PGTCAPTQGKGHT NVRPASEPSP*STAWFATSGSTRKPGMPNTTGR TATRKSGVRRTARMSPPTAATTPSQRTRLSWLPM PATTWLSPGAGRRAWPVPPRTAATGRRRSRQGG RLSLARVTLTQRARRPWGRTCWSRAARGLPTQS WPQLMAPPSSWGWSDSLSPPQHRQKPAEQSVYTS WGFLSALWLLRSERERERERERERERQAGAWLL AQCHSLTAACAGGHSPCRFQCLNYLPDPSILSW VLYFSKMTS*TKQIL**IVWRGPLHLSISVILYW CV*ACSCESVIAPFVL*AGNRRKKHTLGYP*PI TGRK*CEFHVNDQRKDG*DDNFLNRHFPFFFVL HGGAVIWSLVLQDVVDEGFQYGFRPKPGKILASA SCPFPVCQH*TWSLFKFQDIHS*L*RRVTPLAS *PMENMHG*DIFDCLLFPFSICIINIIIIIIII SSSVCCSLQ*AESNGQYLSWETCAAPRSPC*RVP AVVVGTLGW*LFYCNETSLSSVTAEFRRGREQS SQAWSRSSSERVE*GCMHPGNRHQEARAVPGAL QR*LWRKQSSDPVTRHITRERGIPSLPAKPNPSL TQLCYCHLQSKEILLLVIKLHMQDVR*EIGLYL PSCDVGLVLEDKCAVSSFLNSPHPWMQKGRVIF THEHPVQAIDFPHCLRLQGGECTPLHLSSWSLSQ DLRGPQPACCWGPLCLLQCMEPLAFPWGGTPVP QLPSPGLFWPQCSSFT*TCSHRNVHAPFSPPLH QFLKSNLPDFTGR*IFLR**KVISSHTKGKKVEV YMIFNCIRGV*TSLKTRFYLL*R*MQIRTNDPL AYLVKTSSYIP*

Frame 1

CQGAKRPARPLLRLCVPGVVALRCDPAHVWAQP GSAPQ*GGQLDNTKKTVSTSTTKRRRQEVNTDS FSTPCE**LQQGKVS*SISGSENGVL*QRLLRSL NPCPNDVKFARWLGRFRPIFHQHHDVGGHECRE GHREWREPPGDQVPLEASRTKSDWQKEPGNERG EVFL*LPPV*EDLHYPAPADHAHSPAQHRHWRSR PLMQHLRKVTELGQLPRSPHAGALWREALQVHC VWPVIYHQWEHAQTYEDP*EGP*QCHSHSPSIS SET*AIVLQEETESRCRVRERRPSTS*KDGRRRA VR*LGEES**SLSLPSMFQGVCLQVWTGDPHGD PFR*PTKM*HLLCHLSNTSRTAASQRACPQTTS QGCNGQTFHTEQPFNSCWLPRLRIHGLLL*EVSS HFSGLVRNKPAEVHQRATPFCLRHL*QGVPHAL LTGSAQADPCGGRPGSRKAAGHAPAW*RPGPEG LPGLAWPAAHQRRQACPRRGAPAG*QPGNSAPDT QVSATSGPRLHQPAEPVTFRSCFPRRFSHSSPR DQGQHKAPVPAALPEGLHHPA*QQHCGQAHLWR VGHRAGRHPANSEDGSLGSPSDQSSALLQGPCRP TAGDLQAHAPSEAKAPGHTTDGGGHLHAPASHQ RPAGFPGLYQPQPAATAPEAPQRLSGGGLQRPP AAVQVRDPAPRGHAALPAAAAGGAAGPA*DEDAA GAGQHHRGPAAAEHGGQDQAGDHRGGTQGLHDS ARRQEDARHAQGALPLPLLQPGVCLLGGLACPR ALPPGHLAIPVQHLRLHRRRQGRAHPPPAHAQWG AALHLQDLPLPLHCQSQLRAAPAQEAPQGHPQG YREEHRVCE*QRGRAGGRLLRPGHRVPAVRRGP QALSCPAHPHAHALRPRPGRGPQGPQALRVQGVQ RRVRGQAQLHPPHPQAAPARARAGHRELRAGRR RPGPRRGAGR*GVGARGGQWLRCPW*LQAPHCL PGTPERLSSQGPHPASTSPCLDQVGARQ*LCGGL Q*APGLLAEGPGPGPSEAGKHLLSEPFFPGPL* LLHGAHRPVHPQELQERGQGFGHSQRSQEA*GG GGEQRAALSLPSTRPFSSCNFGAQRNPGKPHGPC SGGHPGTPSTAPAGPCSAGGPNLLLSPGQQPST RGQLSPPEWHSLAASTAAQAPAAFAKAPRDRRA APAGLHCPDHLICILGPHPAENQGGGPRARKHWQ *HHGFRQLRRFCPQSRHHRHPRCHHQPKRV**A SRSSQQPRGCLSHRAGPSGHVEEEGPEKGDEEP TPRQQRRGGPGLQRGVCQHREDAGHHRHQQVQSV SADSGGQHSG*GGRSPCRPPWAQ**RAGQSPRR QAAEGQAELVHQLPAEDHLSPLSPGFPLGQLPT EAHAHTHWSETLPLSKMRCLLFYQI*L*TPPVAQ TRSYHLFPEKKRAYPPVKRE*CWIP**HRQSVG CGDCSRRGRSARPHLTGQRAAVGGRH*APPGRR GCACGAGHGGNGLAGAPGRARAWGEP*AGGGAWH *GEHWGRRRRGRGRVEQPEPGPGLRHQAHGLQA GGGRRRGRRRGRGLAGAEARLRHLWEELQVPGH PEPPPEGARPPGAQGREGRWRQHCRGGAPARP*T GGEAPRDPGRGGGVGPGCRGGPGGKARGGDGGP LRRGERGREKVLREERR*QETKDRLPQKRGQQG RQEEEGLQRVQQAVLVAAGPDPAHALPHRGKAIQ MSDLRANLHLEAQPGSPPADPPESQACQTPREG QRQGRAG*GGQRE*VHPQRQQRRLRERG*AGSQ CQQPHGCHPEPEGGLGQCHQGLQPQGGEGHGRVA V*AWPG*P*PREPGGPGAGPAGAAQQEACPPNP GHS*WRLPARGDGVTASVPLSTDKSQQSKASIL HGVSSVPFGC*GVRERERERERERERDKQERGCS LSAIALPQPAREATARADSSALTTYRIPPYYHG CCIFPK*LLKQNKYYNELSGEDLFI*ALALFCI GVCELVLVNL**HRLFCELETEGKNIPLGTHSQ* LEENDVNFM*MTRGKMDKMIIS*IDIFLFSLCF MVELSSGPWYYRMWLMKVSNMVSGQNQGRF*LQ PHVHFQSVSIRHGHCSSFKTSILNYREELLPWRL NLWKTCTDRIYLIASSSLSVYVLLILLLLLLLL VHQFAVLCSEQNQMGNICPGRPVPHPGPRVNVC LRLWLAPSGGSSSTVMRQAFLLSLQNLEGAVSSL PKHGPGAAQRGWSEDACIQGTGIKKPGPCLEHC RDDFGESKAVTQ*PGTLLVSEVFPVFLLSLIQA LPSCATVICKARKYYYW**NYTCKMSDKK*VYIY LPAMWGWCLKINVLFLVS*IAHTPGCKKAGLFL PMSILCRQ*TSLTVSACREENVPHCT*APGPSA KTSGVPSQPAAGDPCACCSVWSLLPSPGEAPLYP SFLPLAFSGPSAPPLHRLVHTETCTPPFLRHFT SF*NPTSQTSQEDRYS*DNEK*YLRIRKEKRLR YI*FLTVLGVYEPV*KRGFIYCRDECKSEPMIPW PT*LKPVHTSLR

Frame 2

AREPSVLPGRCSDCVFQEWWL*GVTLPTFGPSQ VQPPNKEGSLITQRKQCQRVLPREEDKRSTQTH FLLRVNDSYSRGKFHSLSVGQKMEFYSRGFLEA *TPVPMTSSSPAGLEGSDLSSINTMMSAVMSVGK VTENGGSPQGIKSPSKPPGPNRIGRRNQETKEE KSSYNCPLCEKICTTQHQLTMHIRQHNTDTGGA DHSCSICGKSLSSASSLDRHMLVHSGERPYKCTV CGQSFTTNGNMHRHMKIHEKDPNSATATAPPSP LKRRRLSSKRKLSHDAESEREDPAPAKKMVEDG QSGDLEKKADEVFHCPVCFKEFVCKYGLETHMET HSDNPLRCDICCVTFRTHRGLLRHNALVHKQLP RDAMGRPFIQNNPSIPAGFHDLGFTDFSCRKFP RISQAWCETNLRRCISEQHRFVCDTCDKAFPMLC SLALHKQTHVAADQGQEKPQATPLPGDALDQKG FLALLGLQHTKDVRPAPAEEPLPDDNQAIQLQT LKCQLPQDPGCTNLLSLSPFEAASLGGSLTVLPA TKDSIKHLSLQPFQKGFIIQPDSSIVVKPISGE SAIELADIQQILKMAASAPPQISLPPFSKAPAA PLQAIFKHMPPLKPKPLVTPRTVVATSTPPPLIN AQQASPGCISPSLPPPPLKLLKGSVEAASNAHL LQSKSGTQPHAATRLSLQQPRAELPGQPEMKTQ LEQDSIIEALLPLSMEAKIKQEITEGELKAFMTA PGGKKTPAMRKVLYPCRFCNQVFAFSGVLRAHV RSHLGISPYQCNICDYIAADKAALIRHLRTHSG ERPYICKICHYPFTVKANCERHLRKKHLKATRKD IEKNIEYVSSSAAELVDAFCAPDTVCRLCGEDL KHYRALRIHMRTHCGRGLGGGHKGRKPFECKEC SAAFAAKRNCIHHILKQHLHVPEQDIESYVLAAD GLGPAEAPAAEASGRGEDSGCAALGDCKPLTAF LEPQNGFLHRGPTQPPPPHVSIKLEPASSFAVD FNEPLDFSQKGLALVQVKQENISFLSPSSLVPYD CSMEPIDLSIPKNFRKGDKDLATPSEAKKPEEE AGSSEQPSPCPAPGPSLPVTLGPSGILESPMAP APAATPEPPAQPLQGPVQLAVPIYSSALVSSPPL VGSSALLSGTALLRPLRPKPPLLLPKPPVTEEL PPLASIAQIISSVSSAPTLLKTKVADPGPASTG SNTTASDSLGGSVPKAATTATPAATTSPKESSEP PAPASSPEAASPTEQGPAGTSKKRGRKRGMRSR PRANSGGVDLDSSGEFASIEKMLATTDTNKFSP FLQTAEDNTQDEVAGAPADHHGPSDEEQGSPPED KLLRAKRNSYTNCLQKITCPHCPRVFPWASSLQ RHMLTHTGQKPFPCQKCDAFFSTKSNCERHQLR KHGVTTCSLRRNGLIPQSKESDVGSHDSTDSQSD AETAAAAGEVLDLTSRDREQPSEGATELRQVAG DAPVEQATAETASPVHREEHGRGESHEPEEEHG TEESTGDADGAEEDASSNQSLDLDFATKLMDFKL AEGDGEAGAGGAASQEQKLACDTCGKSFKFLGT LSRHRKAHGRQEPKDEKGDGASTAEEGPQPAPE QEEKPPETPAEVVESAPGAGEAPAEKLAEETEGP SDGESAAEKRSSEKSDDDKKPKTDSPKSVASKA DKRKKVCSVCNKRFWSLQDLTRHMRSHTGERPY KCQTCERTFTLKHSLVRHQRIHQKARHAKHHGKD SDKEERGEEDSENESTHSGNNAVSENEAELAPN ASNHMAVTRSRKEGLASATKDCSHREEKVTAGW PSEPGQGDLNPESPAALGQDLLEPRSKRPAHPIL ATADGASQLVGME*QPQSPSAQTKASRAKRLYF MGFPQCPLAVEE*ERERERERERERETSRSVAA RSVP*PYRSLRGRPQPVPIPVP*LLTGSLHIIMG VVFFQNDFLNKTNIIMNCLERTSSFEH*RYFVL VCVSLFL*ICDSTVCSVSWKQKEKTYPWVPIAN NWKKMM*ISCK*PEERWIR**FLK*TFSFFLCAS WWSCHLVLGITGCG**RFPIWFQAKTREDSSFS LMSISSLSALDMVTVQVSRHPFLTIEKSYSPGV LTYGKHARIGYI*LPPLPFQYMYY*YYYYYYYY* FISLLFSAVSRIKWAIFVLGDLCRTQVPVLTCA CGCGWHPRVVALLL**DKPFFCHCRI*KGP*AV FPSMVQEQLREGGVRMHASREQASRSQGRAWSTA EMTLEKAKQ*PSDQAHYS*ARYSQSSC*A*SKP YPAVLLSFAKQGNTTTGNKTTHARCQIRNRFIF TFLRCGVGA*R*MCCF*FLK*PTPLDAKRQGYFY P*ASCAGNRLPSLSPPAGRRMYPTAPELLVPQP RPQGSPASLLLGTPVLAAVYGASCLPLGRHPCT PASFPWPFLAPVLLLYIDLFTQKRARPLFSATSP VSEIQPPRLHRKIDILEIMKSDIFAYERKKG*G IYDF*LY*GCMNQFKNEVLFTVEMNANQNQ*SL GLLS*NQFIHPL