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Sequences

Sequence NM_130854

ATTCCATCCCATCACCCCATGATCCTTCCCCATTGTCCCATGACCAGCCCCCGCAGGACCCTCCCCTGCTCCATGTGACCCTCCCTCTGCCTCCTCCATG AAGGTCTCCTGGATTTCCCCACTCGCCTCTCACAGCCCTCCATTGTCTCTGCAGACGTTGCCCCATCTGACGCTCGGCTCGAGGCCTCTCTGTGAGGGAC CGGGGGGCCATCCCCCTCCAGGGCGGAGATCGGAGGTCGCTGCCAAGCATGGCGCCCACCTGGGGCCCTGGCATGGTGTCTGTGGTTGGTCCCATGGGCC TCCTTGTGGTCCTGCTCGTTGGAGGCTGTGCAGCAGAAGAGCCCCCCAGGTTTATCAAAGAACCCAAGGACCAGATCGGCGTGTCGGGGGGTGTGGCCTC TTTCGTGTGTCAGGCCACGGGTGACCCCAAGCCACGAGTGACCTGGAACAAGAAGGGCAAGAAGGTCAACTCTCAGCGCTTTGAGACGATTGAGTTTGAT GAGAGTGCAGGGGCAGTGCTGAGGATCCAGCCGCTGAGGACACCGCGGGATGAAAACGTGTACGAGTGTGTGGCCCAGAACTCGGTTGGGGAGATCACAG TCCATGCCAAGCTTACTGTCCTCCGAGAGGACCAGCTGCCCTCTGGCTTCCCCAACATCGACATGGGCCCACAGTTGAAGGTGGTGGAGCGGACACGGAC AGCCACCATGCTCTGTGCAGCCAGCGGCAACCCTGACCCTGAGATCACCTGGTTCAAGGACTTCCTGCCTGTGGATCCTAGTGCCAGCAATGGACGCATC AAACAGCTGCGATCAGGAGCCCTGCAGATTGAAAGCAGTGAGGAAACCGACCAGGGCAAATATGAGTGTGTGGCCACCAACAGCGCCGGCGTGCGCTACT CCTCACCTGCCAACCTCTACGTGCGAGTCCGCCGCGTGGCCCCGCGCTTCTCCATCCTGCCCATGAGCCACGAGATCATGCCAGGGGGCAACGTGAACAT CACCTGCGTGGCCGTGGGCTCGCCCATGCCATACGTGAAGTGGATGCAGGGGGCCGAGGACCTGACCCCCGAGGATGACATGCCCGTGGGTCGGAACGTG CTGGAACTCACAGATGTCAAGGACTCGGCCAACTACACCTGCGTGGCCATGTCCAGCCTGGGCGTCATTGAGGCGGTTGCTCAGATCACGGTGAAATCTC TCCCCAAAGCTCCCGGGACTCCCATGGTGACTGAGAACACAGCCACCAGCATCACCATCACGTGGGACTCGGGCAACCCAGATCCTGTGTCCTATTACGT CATCGAATATAAATCCAAGAGCCAAGACGGGCCGTATCAGATTAAAGAGGACATCACCACCACACGTTACAGCATCGGCGGCCTGAGCCCCAACTCGGAG TACGAGATCTGGGTGTCGGCCGTCAACTCCATCGGCCAGGGGCCCCCCAGCGAGTCCGTGGTCACCCGCACAGGCGAGCAGGCCCCGGCCAGCGCGCCGC GGAACGTGCAAGCCCGGATGCTCAGCGCGACCACCATGATTGTGCAGTGGGAGGAGCCGGTGGAGCCCAACGGCCTGATCCGCGGCTACCGCGTCTACTA CACCATGGAACCGGAGCACCCCGTGGGCAACTGGCAGAAGCACAACGTGGACGACAGCCTGCTGACCACCGTGGGCAGCCTGCTGGAGGACGAGACCTAC ACCGTGCGGGTGCTCGCCTTCACCTCCGTCGGCGACGGGCCCCTCTCGGACCCCATCCAGGTCAAGACGCAGCAGGGAGTGCCGGGCCAGCCCATGAACC TGCGGGCCGAGGCCAGGTCGGAGACCAGCATCACGCTGTCCTGGAGCCCCCCGCGGCAGGAGAGTATCATCAAGTACGAGCTCCTCTTCCGGGAAGGCGA CCATGGCCGGGAGGTGGGAAGGACCTTCGACCCGACGACTTCCTACGTGGTGGAGGACCTGAAGCCCAACACGGAGTACGCCTTCCGCCTGGCGGCCCGC TCGCCGCAGGGCCTGGGCGCCTTCACCCCCGTGGTGCGGCAGCGCACGCTGCAGTCCAAACCGTCAGCCCCCCCTCAAGACGTTAAATGTGTCAGCGTGC GCTCCACGGCCATTTTGGTAAGTTGGCGCCCGCCGCCGCCGGAAACGCACAACGGGGCCCTGGTGGGCTACAGCGTCCGCTACCGACCGCTGGGCTCAGA GGACCCGGAACCCAAGGAGGTGAACGGCATCCCCCCGACCACCACTCAGATCCTGCTGGAGGCCTTGGAGAAGTGGACCCAGTACCGCATCACGACTGTC GCTCACACAGAGGTGGGACCAGGGCCCGAGAGCTCGCCCGTGGTCGTCCGCACCGACGAGGATGTGCCCAGCGCGCCGCCGCGGAAGGTGGAGGCGGAGG CGCTCAACGCCACGGCCATCCGCGTGCTGTGGCGCTCGCCCGCGCCCGGCCGGCAGCACGGCCAGATCCGCGGCTACCAGGTCCACTACGTGCGCATGGA GGGCGCCGAGGCCCGCGGGCCGCCGCGCATCAAGGACGTCATGCTGGCCGATGCCCAGGAGATGGTCATCACAAACTTGCAGCCTGAGACCGCGTACTCC ATCACGGTAGCCGCCTACACCATGAAGGGCGATGGCGCTCGCAGCAAACCCAAGGTGGTTGTGACCAAGGGAGCAGTGCTGGGCCGCCCAACCCTGTCGG TGCAGCAGACCCCCGAGGGCAGCCTGCTGGCACGCTGGGAGCCCCCGGCTGGCACCGCGGAGGACCAGGTGCTGGGCTACCGCCTGCAGTTTGGCCGTGA GGACTCGACGCCCCTGGCCACCCTGGAGTTCCCGCCCTCCGAGGACCGCTACACGGCATCAGGCGTGCACAAGGGGGCCACGTATGTGTTCCGGCTTGCG GCCCGGAGCCGCGGCGGCCTGGGCGAGGAGGCAGCCGAGGTCCTGAGCATCCCGGAGGACACGCCCCGTGGCCACCCGCAGATTCTGGAGGCGGCCGGCA ACGCCTCGGCCGGGACCGTCCTTCTCCGCTGGCTGCCACCCGTGCCCGCCGAGCGCAACGGGGCCATCGTCAAATACACGGTGGCCGTGCGGGAGGCCGG TGCCCTGGGCCCTGCCCGAGAGACTGAGCTGCCGGCAGCGGCTGAGCCGGGCGCGGAGAACGCGCTCACGCTGCAGGGCCTGAAGCCCGACACGGCCTAT GACCTCCAAGTGCGAGCCCACACGCGCCGGGGCCCTGGCCCCTTCAGCCCCCCCGTCCGCTACCGGACGTTCCTGCGGGACCAAGTCTCGCCCAAGAACT TCAAGGTGAAAATGATCATGAAGACATCAGTTCTGCTCAGCTGGGAGTTCCCTGACAACTACAACTCACCCACACCCTACAAGATCCAGTACAATGGGCT CACACTGGATGTGGATGGCCGTACCACCAAGAAGCTCATCACGCACCTCAAGCCCCACACCTTCTACAACTTTGTGCTGACCAATCGCGGCAGCAGCCTG GGCGGCCTCCAGCAGACGGTCACCGCCTGGACTGCCTTCAACCTGCTCAACGGCAAGCCCAGCGTCGCCCCCAAGCCTGATGCTGACGGCTTCATCATGG TGTATCTTCCTGACGGCCAGAGCCCCGTGCCTGTCCAGAGCTATTTCATTGTGATGGTGCCACTGCGCAAGTCTCGTGGAGGCCAATTCCTGACCCCGCT GGGTAGCCCAGAGGACATGGATCTGGAAGAGCTCATCCAGGACATCTCACGGCTACAGAGGCGCAGCCTGCGGCACTCGCGTCAGCTGGAGGTGCCCCGG CCCTATATTGCAGCTCGCTTCTCTGTGCTGCCACCCACGTTCCATCCCGGCGACCAGAAGCAGTATGGCGGCTTCGATAACCGGGGCCTGGAGCCCGGCC ACCGCTATGTCCTCTTCGTGCTTGCCGTGCTTCAGAAGAGCGAGCCTACCTTTGCAGCCAGTCCCTTCTCAGACCCCTTCCAGCTGGATAACCCGGACCC CCAGCCCATCGTGGATGGCGAGGAGGGGCTTATCTGGGTGATCGGGCCTGTGCTGGCCGTGGTCTTCATAATCTGCATTGTCATTGCTATCCTGCTCTAC AAGAACAAACCCGACAGTAAACGCAAGGACTCAGAACCCCGCACCAAATGCCTCCTGAACAATGCCGACCTCGCCCCTCACCACCCCAAGGACCCTGTGG AAATGAGACGCATTAACTTCCAGACTCCAGGCATGCTTAGCCACCCGCCAATTCCCATCGCAGACATGGCGGAGCACACGGAGCGGCTCAAGGCCAACGA CAGCCTCAAGCTCTCCCAGGAGTATGAGTCCATCGACCCTGGACAGCAGTTCACATGGGAACATTCCAACCTGGAAGTGAACAAGCCGAAGAACCGCTAT GCCAACGTCATCGCCTATGACCACTCCCGTGTCATCCTCCAGCCCATTGAAGGCATCATGGGCAGTGATTACATCAATGCCAACTACGTGGACGGCTACC GGTGTCAGAACGCGTACATTGCCACGCAGGGGCCGCTGCCTGAGACCTTTGGGGACTTCTGGCGTATGGTGTGGGAGCAGCGGTCGGCGACCATCGTCAT GATGACGCGGCTGGAGGAGAAGTCACGGATCAAGTGTGATCAGTATTGGCCCAACAGAGGCACGGAGACCTACGGCTTCATCCAGGTCACGTTGCTAGAT ACCATCGAGCTGGCCACATTCTGCGTCAGGACATTCTCTCTGCACAAGAATGGCTCCAGTGAGAAACGCGAGGTCCGCCAGTTCCAGTTTACGGCGTGGC CGGACCATGGCGTGCCCGAATACCCAACGCCCTTCCTGGCTTTCCTGCGGAGAGTCAAGACCTGCAACCCGCCAGATGCCGGCCCCATCGTGGTTCACTG CAGTGCCGGTGTGGGCCGCACAGGCTGCTTTATCGTCATCGACGCCATGCTTGAGCGGATCAAGCCAGAGAAGACAGTCGATGTCTATGGCCACGTGACG CTCATGAGGTCCCAGCGCAACTACATGGTGCAGACGGAGGACCAGTACAGCTTCATCCACGAGGCCCTGCTGGAGGCCGTGGGCTGTGGCAACACAGAAG TGCCCGCACGCAGCCTCTATGCCTACATCCAGAAGCTGGCCCAGGTGGAGCCTGGCGAACACGTCACTGGCATGGAACTCGAGTTCAAGCGGCTGGCTAA CTCCAAGGCCCACACGTCACGCTTCATCAGTGCCAATCTGCCTTGTAACAAGTTCAAGAACCGCCTGGTGAACATCATGCCCTATGAGAGCACACGGGTC TGTCTGCAACCCATCCGGGGTGTGGAGGGCTCTGACTACATCAACGCCAGCTTCATTGATGGCTACAGGCAGCAGAAGGCCTACATCGCGACACAGGGGC CGCTGGCGGAGACCACGGAAGACTTCTGGCGCATGCTGTGGGAGAACAATTCGACGATCGTGGTGATGCTGACCAAGCTGCGGGAGATGGGCCGGGAGAA GTGTCACCAGTACTGGCCGGCCGAGCGCTCTGCCCGCTACCAGTACTTTGTGGTAGATCCGATGGCAGAATACAACATGCCTCAGTATATCCTGCGAGAG TTCAAGGTCACAGATGCCCGGGATGGCCAGTCCCGGACTGTCCGGCAGTTCCAGTTCACAGACTGGCCGGAACAGGGTGTGCCAAAGTCGGGGGAGGGCT TCATCGACTTCATTGGCCAAGTGCATAAGACTAAGGAGCAGTTTGGCCAGGACGGCCCCATCTCTGTCCACTGCAGTGCCGGCGTGGGCAGGACGGGCGT CTTCATCACGCTTAGCATCGTGCTGGAGCGGATGCGGTATGAAGGCGTGGTGGACATCTTTCAGACGGTGAAGATGCTACGAACCCAGCGGCCGGCCATG GTGCAGACAGAGGATGAGTACCAGTTCTGTTACCAGGCGGCACTGGAGTACCTCGGAAGCTTTGACCACTATGCAACCTAAAGCCATGGTTCCCCCCAGG CCCGACACCACTGGCCCCGGATGCCTCTGCCCCTCCCGGGCGGACCTCCTGAGGCCTGGACCCCCAGTGGGCAGGGCAGGAGGTGGCAGCGGCAGCAGCT GTGTTTCTGCACCATTTCCGAGGACGACGCAGCCCCTCGAGCCCCCCCACCGGCCCCGGCCGCCCCAGCGACCTCCCTGGCACCGGCCGCCGCCTTCAAA TACTTGGCACATTCCTCCTTTCCTTCCAATTCCAAAACCAGATTCCGGGGTGGGGGGTGGGGGGATGGTGAGCAAATAGGAGTGCTCCCCAGAACCAGAG GAGGGTGGGGCACAGACCATAGACGGACCCCTCGTCCTCCCCCAGCGGTGGTAGGGGGACCCGGGGGGCTCCTCCCCGCTCTGCAGC

refseq_PTPRS.F2 (forward primer)
refseq_PTPRS.R2 (reverse primer)
Single exon skipping

Frame 0

IPSHHPMILPHCPMTSPRRTLPCSM*PSLCLLH EGLLDFPTRLSQPSIVSADVAPSDARLEASL*GT GGPSPSRAEIGGRCQAWRPPGALAWCLWLVPWA SLWSCSLEAVQQKSPPGLSKNPRTRSACRGVWP LSCVRPRVTPSHE*PGTRRARRSTLSALRRLSLM RVQGQC*GSSR*GHRGMKTCTSVWPRTRLGRSQ SMPSLLSSERTSCPLASPTSTWAHS*RWWSGHG QPPCSVQPAATLTLRSPGSRTSCLWILVPAMDAS NSCDQEPCRLKAVRKPTRANMSVWPPTAPACAT PHLPTSTCESAAWPRASPSCP*ATRSCQGAT*T SPAWPWARPCHT*SGCRGPRT*PPRMTCPWVGTC WNSQMSRTRPTTPAWPCPAWASLRRLLRSR*NL SPKLPGLPW*LRTQPPASPSRGTRATQILCPIT SSNINPRAKTGRIRLKRTSPPHVTASAA*APTRS TRSGCRPSTPSARGPPASPWSPAQASRPRPARR GTCKPGCSARPP*LCSGRSRWSPTA*SAATAST TPWNRSTPWATGRSTTWTTAC*PPWAACWRTRPT PCGCSPSPPSATGPSRTPSRSRRSRECRASP*T CGPRPGRRPASRCPGAPRGRRVSSSTSSSSGKA TMAGRWEGPSTRRLPTWWRT*SPTRSTPSAWRPA RRRAWAPSPPWCGSARCSPNRQPPLKTLNVSAC APRPFW*VGARRRRKRTTGPWWATASATDRWAQ RTRNPRR*TASPRPPLRSCWRPWRSGPSTASRLS LTQRWDQGPRARPWSSAPTRMCPARRRGRWRRR RSTPRPSACCGARPRPAGSTARSAATRSTTCAW RAPRPAGRRASRTSCWPMPRRWSSQTCSLRPRTP SR*PPTP*RAMALAANPRWL*PREQCWAAQPCR CSRPPRAACWHAGSPRLAPRRTRCWATACSLAV RTRRPWPPWSSRPPRTATRHQACTRGPRMCSGLR PGAAAAWARRQPRS*ASRRTRPVATRRFWRRPA TPRPGPSFSAGCHPCPPSATGPSSNTRWPCGRP VPWALPERLSCRQRLSRARRTRSRCRA*SPTRPM TSKCEPTRAGALAPSAPPSATGRSCGTKSRPRT SR*K*S*RHQFCSAGSSLTTTTHPHPTRSSTMG SHWMWMAVPPRSSSRTSSPTPSTTLC*PIAAAAW AASSRRSPPGLPSTCSTASPASPPSLMLTASSW CIFLTARAPCLSRAISL*WCHCASLVEANS*PR WVAQRTWIWKSSSRTSHGYRGAACGTRVSWRCPG PILQLASLCCHPRSIPATRSSMAASITGAWSPA TAMSSSCLPCFRRASLPLQPVPSQTPSSWITRT PSPSWMARRGLSG*SGLCWPWSS*SALSLLSCST RTNPTVNARTQNPAPNAS*TMPTSPLTTPRTLW K*DALTSRLQACLATRQFPSQTWRSTRSGSRPT TASSSPRSMSPSTLDSSSHGNIPTWK*TSRRTAM PTSSPMTTPVSSSSPLKASWAVITSMPTTWTAT GVRTRTLPRRGRCLRPLGTSGVWCGSSGRRPSS **RGWRRSHGSSVISIGPTEARRPTASSRSRC*I PSSWPHSASGHSLCTRMAPVRNARSASSSLRRG RTMACPNTQRPSWLSCGESRPATRQMPAPSWFT AVPVWAAQAALSSSTPCLSGSSQRRQSMSMAT*R S*GPSATTWCRRRTSTASSTRPCWRPWAVATQK CPHAASMPTSRSWPRWSLANTSLAWNSSSSGWL TPRPTRHASSVPICLVTSSRTAW*TSCPMRAHGS VCNPSGVWRALTTSTPASLMATGSRRPTSRHRG RWRRPRKTSGACCGRTIRRSW*C*PSCGRWAGR SVTSTGRPSALPATSTLW*IRWQNTTCLSISCES SRSQMPGMASPGLSGSSSSQTGRNRVCQSRGRA SSTSLAKCIRLRSSLARTAPSLSTAVPAWAGRA SSSRLASCWSGCGMKAWWTSFRR*RCYEPSGRPW CRQRMSTSSVTRRHWSTSEALTTMQPKAMVPPR PDTTGPGCLCPSRADLLRPGPPVGRAGGGSGSS CVSAPFPRTTQPLEPPHRPRPPQRPPWHRPPPSN TWHIPPFLPIPKPDSGVGGGGMVSK*ECSPEPE EGGAQTIDGPLVLPQRW*GDPGGSSPLCS

Frame 1

FHPITP*SFPIVP*PAPAGPSPAPCDPPSASSM KVSWISPLASHSPPLSLQTLPHLTLGSRPLCEG PGGHPPPGRRSEVAAKHGAHLGPWHGVCGWSHGP PCGPARWRLCSRRAPQVYQRTQGPDRRVGGCGL FRVSGHG*PQATSDLEQEGQEGQLSAL*DD*V* *ECRGSAEDPAAEDTAG*KRVRVCGPELGWGDHS PCQAYCPPRGPAALWLPQHRHGPTVEGGGADTD SHHALCSQRQP*P*DHLVQGLPACGS*CQQWTH QTAAIRSPAD*KQ*GNRPGQI*VCGHQQRRRALL LTCQPLRASPPRGPALLHPAHEPRDHARGQREH HLRGRGLAHAIREVDAGGRGPDPRG*HARGSER AGTHRCQGLGQLHLRGHVQPGRH*GGCSDHGEIS PQSSRDSHGD*EHSHQHHHHVGLGQPRSCVLLR HRI*IQEPRRAVSD*RGHHHHTLQHRRPEPQLG VRDLGVGRQLHRPGAPQRVRGHPHRRAGPGQRAA ERASPDAQRDHHDCAVGGAGGAQRPDPRLPRLL HHGTGAPRGQLAEAQRGRQPADHRGQPAGGRDL HRAGARLHLRRRRAPLGPHPGQDAAGSAGPAHEP AGRGQVGDQHHAVLEPPAAGEYHQVRAPLPGRR PWPGGGKDLRPDDFLRGGGPEAQHGVRLPPGGP LAAGPGRLHPRGAAAHAAVQTVSPPSRR*MCQRA LHGHFGKLAPAAAGNAQRGPGGLQRPLPTAGLR GPGTQGGERHPPDHHSDPAGGLGEVDPVPHHDC RSHRGGTRARELARGRPHRRGCAQRAAAEGGGGG AQRHGHPRAVALARARPAARPDPRLPGPLRAHG GRRGPRAAAHQGRHAGRCPGDGHHKLAA*DRVL HHGSRLHHEGRWRSQQTQGGCDQGSSAGPPNPVG AADPRGQPAGTLGAPGWHRGGPGAGLPPAVWP* GLDAPGHPGVPALRGPLHGIRRAQGGHVCVPAC GPEPRRPGRGGSRGPEHPGGHAPWPPADSGGGRQ RLGRDRPSPLAATRARRAQRGHRQIHGGRAGGR CPGPCPRD*AAGSG*AGRGERAHAAGPEARHGL *PPSASPHAPGPWPLQPPRPLPDVPAGPSLAQEL QGENDHEDISSAQLGVP*QLQLTHTLQDPVQWA HTGCGWPYHQEAHHAPQAPHLLQLCADQSRQQP GRPPADGHRLDCLQPAQRQAQRRPQA*C*RLHHG VSS*RPEPRACPELFHCDGATAQVSWRPIPDPA G*PRGHGSGRAHPGHLTATEAQPAALASAGGAP ALYCSSLLCAATHVPSRRPEAVWRLR*PGPGARP PLCPLRACRASEERAYLCSQSLLRPLPAG*PGP PAHRGWRGGAYLGDRACAGRGLHNLHCHCYPAL QEQTRQ*TQGLRTPHQMPPEQCRPRPSPPQGPCG NETH*LPDSRHA*PPANSHRRHGGAHGAAQGQR QPQALPGV*VHRPWTAVHMGTFQPGSEQAEEPL CQRHRL*PLPCHPPAH*RHHGQ*LHQCQLRGRLP VSERVHCHAGAAA*DLWGLLAYGVGAAVGDHRH DDAAGGEVTDQV*SVLAQQRHGDLRLHPGHVAR YHRAGHILRQDILSAQEWLQ*ETRGPPVPVYGVA GPWRARIPNALPGFPAESQDLQPARCRPHRGSL QCRCGPHRLLYRHRRHA*ADQAREDSRCLWPRD AHEVPAQLHGADGGPVQLHPRGPAGGRGLWQHRS ARTQPLCLHPEAGPGGAWRTRHWHGTRVQAAG* LQGPHVTLHQCQSAL*QVQEPPGEHHAL*EHTG LSATHPGCGGL*LHQRQLH*WLQAAEGLHRDTGA AGGDHGRLLAHAVGEQFDDRGDADQAAGDGPGE VSPVLAGRALCPLPVLCGRSDGRIQHASVYPAR VQGHRCPGWPVPDCPAVPVHRLAGTGCAKVGGGL HRLHWPSA*D*GAVWPGRPHLCPLQCRRGQDGR LHHA*HRAGADAV*RRGGHLSDGEDATNPAAGH GADRG*VPVLLPGGTGVPRKL*PLCNLKPWFPPG PTPLAPDASAPPGRTS*GLDPQWAGQEVAAAAA VFLHHFRGRRSPSSPPTGPGRPSDLPGTGRRLQ ILGTFLLSFQFQNQIPGWGVGGW*ANRSAPQNQR RVGHRP*TDPSSSPSGGRGTRGAPPRSA

Frame 2

SIPSPHDPSPLSHDQPPQDPPLLHVTLPLPPP* RSPGFPHSPLTALHCLCRRCPI*RSARGLSVRD RGAIPLQGGDRRSLPSMAPTWGPGMVSVVGPMG LLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVAS FVCQATGDPKPRVTWNKKGKKVNSQRFETIEFD ESAGAVLRIQPLRTPRDENVYECVAQNSVGEIT VHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRT ATMLCAASGNPDPEITWFKDFLPVDPSASNGRI KQLRSGALQIESSEETDQGKYECVATNSAGVRY SSPANLYVRVRRVAPRFSILPMSHEIMPGGNVNI TCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNV LELTDVKDSANYTCVAMSSLGVIEAVAQITVKS LPKAPGTPMVTENTATSITITWDSGNPDPVSYYV IEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSE YEIWVSAVNSIGQGPPSESVVTRTGEQAPASAP RNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYY TMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETY TVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMN LRAEARSETSITLSWSPPRQESIIKYELLFREGD HGREVGRTFDPTTSYVVEDLKPNTEYAFRLAAR SPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSV RSTAILVSWRPPPPETHNGALVGYSVRYRPLGSE DPEPKEVNGIPPTTTQILLEALEKWTQYRITTV AHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAE ALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRME GAEARGPPRIKDVMLADAQEMVITNLQPETAYS ITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLS VQQTPEGSLLARWEPPAGTAEDQVLGYRLQFGRE DSTPLATLEFPPSEDRYTASGVHKGATYVFRLA ARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAG NASAGTVLLRWLPPVPAERNGAIVKYTVAVREAG ALGPARETELPAAAEPGAENALTLQGLKPDTAY DLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKN FKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGL TLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSL GGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIM VYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPL GSPEDMDLEELIQDISRLQRRSLRHSRQLEVPR PYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPG HRYVLFVLAVLQKSEPTFAASPFSDPFQLDNPDP QPIVDGEEGLIWVIGPVLAVVFIICIVIAILLY KNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPV EMRRINFQTPGMLSHPPIPIADMAEHTERLKAND SLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRY ANVIAYDHSRVILQPIEGIMGSDYINANYVDGY RCQNAYIATQGPLPETFGDFWRMVWEQRSATIVM MTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLD TIELATFCVRTFSLHKNGSSEKREVRQFQFTAW PDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHC SAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVT LMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTE VPARSLYAYIQKLAQVEPGEHVTGMELEFKRLAN SKAHTSRFISANLPCNKFKNRLVNIMPYESTRV CLQPIRGVEGSDYINASFIDGYRQQKAYIATQG PLAETTEDFWRMLWENNSTIVVMLTKLREMGREK CHQYWPAERSARYQYFVVDPMAEYNMPQYILRE FKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEG FIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGV FITLSIVLERMRYEGVVDIFQTVKMLRTQRPAM VQTEDEYQFCYQAALEYLGSFDHYAT*SHGSPQ ARHHWPRMPLPLPGGPPEAWTPSGQGRRWQRQQL CFCTISEDDAAPRAPPPAPAAPATSLAPAAAFK YLAHSSFPSNSKTRFRGGGWGDGEQIGVLPRTR GGWGTDHRRTPRPPPAVVGGPGGLLPALQ

Sequence NM_130853

ATTCCATCCCATCACCCCATGATCCTTCCCCATTGTCCCATGACCAGCCCCCGCAGGACCCTCCCCTGCTCCATGTGACCCTCCCTCTGCCTCCTCCATG AAGGTCTCCTGGATTTCCCCACTCGCCTCTCACAGCCCTCCATTGTCTCTGCAGACGTTGCCCCATCTGACGCTCGGCTCGAGGCCTCTCTGTGAGGGAC CGGGGGGCCATCCCCCTCCAGGGCGGAGATCGGAGGTCGCTGCCAAGCATGGCGCCCACCTGGGGCCCTGGCATGGTGTCTGTGGTTGGTCCCATGGGCC TCCTTGTGGTCCTGCTCGTTGGAGGCTGTGCAGCAGAAGAGCCCCCCAGGTTTATCAAAGAACCCAAGGACCAGATCGGCGTGTCGGGGGGTGTGGCCTC TTTCGTGTGTCAGGCCACGGGTGACCCCAAGCCACGAGTGACCTGGAACAAGAAGGGCAAGAAGGTCAACTCTCAGCGCTTTGAGACGATTGAGTTTGAT GAGAGTGCAGGGGCAGTGCTGAGGATCCAGCCGCTGAGGACACCGCGGGATGAAAACGTGTACGAGTGTGTGGCCCAGAACTCGGTTGGGGAGATCACAG TCCATGCCAAGCTTACTGTCCTCCGAGAGGACCAGCTGCCCTCTGGCTTCCCCAACATCGACATGGGCCCACAGTTGAAGGTGGTGGAGCGGACACGGAC AGCCACCATGCTCTGTGCAGCCAGCGGCAACCCTGACCCTGAGATCACCTGGTTCAAGGACTTCCTGCCTGTGGATCCTAGTGCCAGCAATGGACGCATC AAACAGCTGCGATCAGGAGCCCTGCAGATTGAAAGCAGTGAGGAAACCGACCAGGGCAAATATGAGTGTGTGGCCACCAACAGCGCCGGCGTGCGCTACT CCTCACCTGCCAACCTCTACGTGCGAGTCCGCCGCGTGGCCCCGCGCTTCTCCATCCTGCCCATGAGCCACGAGATCATGCCAGGGGGCAACGTGAACAT CACCTGCGTGGCCGTGGGCTCGCCCATGCCATACGTGAAGTGGATGCAGGGGGCCGAGGACCTGACCCCCGAGGATGACATGCCCGTGGGTCGGAACGTG CTGGAACTCACAGATGTCAAGGACTCGGCCAACTACACCTGCGTGGCCATGTCCAGCCTGGGCGTCATTGAGGCGGTTGCTCAGATCACGGTGAAATCTC TCCCCAAAGCTCCCGGGACTCCCATGGTGACTGAGAACACAGCCACCAGCATCACCATCACGTGGGACTCGGGCAACCCAGATCCTGTGTCCTATTACGT CATCGAATATAAATCCAAGAGCCAAGACGGGCCGTATCAGATTAAAGAGGACATCACCACCACACGTTACAGCATCGGCGGCCTGAGCCCCAACTCGGAG TACGAGATCTGGGTGTCGGCCGTCAACTCCATCGGCCAGGGGCCCCCCAGCGAGTCCGTGGTCACCCGCACAGGCGAGCAGGCCCCGGCCAGCGCGCCGC GGAACGTGCAAGCCCGGATGCTCAGCGCGACCACCATGATTGTGCAGTGGGAGGAGCCGGTGGAGCCCAACGGCCTGATCCGCGGCTACCGCGTCTACTA CACCATGGAACCGGAGCACCCCGTGGGCAACTGGCAGAAGCACAACGTGGACGACAGCCTGCTGACCACCGTGGGCAGCCTGCTGGAGGACGAGACCTAC ACCGTGCGGGTGCTCGCCTTCACCTCCGTCGGCGACGGGCCCCTCTCGGACCCCATCCAGGTCAAGACGCAGCAGGGAGTGCCGGGCCAGCCCATGAACC TGCGGGCCGAGGCCAGGTCGGAGACCAGCATCACGCTGTCCTGGAGCCCCCCGCGGCAGGAGAGTATCATCAAGTACGAGCTCCTCTTCCGGGAAGGCGA CCATGGCCGGGAGGTGGGAAGGACCTTCGACCCGACGACTTCCTACGTGGTGGAGGACCTGAAGCCCAACACGGAGTACGCCTTCCGCCTGGCGGCCCGC TCGCCGCAGGGCCTGGGCGCCTTCACCCCCGTGGTGCGGCAGCGCACGCTGCAGTCCATCTCGCCCAAGAACTTCAAGGTGAAAATGATCATGAAGACAT CAGTTCTGCTCAGCTGGGAGTTCCCTGACAACTACAACTCACCCACACCCTACAAGATCCAGTACAATGGGCTCACACTGGATGTGGATGGCCGTACCAC CAAGAAGCTCATCACGCACCTCAAGCCCCACACCTTCTACAACTTTGTGCTGACCAATCGCGGCAGCAGCCTGGGCGGCCTCCAGCAGACGGTCACCGCC TGGACTGCCTTCAACCTGCTCAACGGCAAGCCCAGCGTCGCCCCCAAGCCTGATGCTGACGGCTTCATCATGGTGTATCTTCCTGACGGCCAGAGCCCCG TGCCTGTCCAGAGCTATTTCATTGTGATGGTGCCACTGCGCAAGTCTCGTGGAGGCCAATTCCTGACCCCGCTGGGTAGCCCAGAGGACATGGATCTGGA AGAGCTCATCCAGGACATCTCACGGCTACAGAGGCGCAGCCTGCGGCACTCGCGTCAGCTGGAGGTGCCCCGGCCCTATATTGCAGCTCGCTTCTCTGTG CTGCCACCCACGTTCCATCCCGGCGACCAGAAGCAGTATGGCGGCTTCGATAACCGGGGCCTGGAGCCCGGCCACCGCTATGTCCTCTTCGTGCTTGCCG TGCTTCAGAAGAGCGAGCCTACCTTTGCAGCCAGTCCCTTCTCAGACCCCTTCCAGCTGGATAACCCGGACCCCCAGCCCATCGTGGATGGCGAGGAGGG GCTTATCTGGGTGATCGGGCCTGTGCTGGCCGTGGTCTTCATAATCTGCATTGTCATTGCTATCCTGCTCTACAAGAACAAACCCGACAGTAAACGCAAG GACTCAGAACCCCGCACCAAATGCCTCCTGAACAATGCCGACCTCGCCCCTCACCACCCCAAGGACCCTGTGGAAATGAGACGCATTAACTTCCAGACTC CAGGCATGCTTAGCCACCCGCCAATTCCCATCGCAGACATGGCGGAGCACACGGAGCGGCTCAAGGCCAACGACAGCCTCAAGCTCTCCCAGGAGTATGA GTCCATCGACCCTGGACAGCAGTTCACATGGGAACATTCCAACCTGGAAGTGAACAAGCCGAAGAACCGCTATGCCAACGTCATCGCCTATGACCACTCC CGTGTCATCCTCCAGCCCATTGAAGGCATCATGGGCAGTGATTACATCAATGCCAACTACGTGGACGGCTACCGGTGTCAGAACGCGTACATTGCCACGC AGGGGCCGCTGCCTGAGACCTTTGGGGACTTCTGGCGTATGGTGTGGGAGCAGCGGTCGGCGACCATCGTCATGATGACGCGGCTGGAGGAGAAGTCACG GATCAAGTGTGATCAGTATTGGCCCAACAGAGGCACGGAGACCTACGGCTTCATCCAGGTCACGTTGCTAGATACCATCGAGCTGGCCACATTCTGCGTC AGGACATTCTCTCTGCACAAGAATGGCTCCAGTGAGAAACGCGAGGTCCGCCAGTTCCAGTTTACGGCGTGGCCGGACCATGGCGTGCCCGAATACCCAA CGCCCTTCCTGGCTTTCCTGCGGAGAGTCAAGACCTGCAACCCGCCAGATGCCGGCCCCATCGTGGTTCACTGCAGTGCCGGTGTGGGCCGCACAGGCTG CTTTATCGTCATCGACGCCATGCTTGAGCGGATCAAGCCAGAGAAGACAGTCGATGTCTATGGCCACGTGACGCTCATGAGGTCCCAGCGCAACTACATG GTGCAGACGGAGGACCAGTACAGCTTCATCCACGAGGCCCTGCTGGAGGCCGTGGGCTGTGGCAACACAGAAGTGCCCGCACGCAGCCTCTATGCCTACA TCCAGAAGCTGGCCCAGGTGGAGCCTGGCGAACACGTCACTGGCATGGAACTCGAGTTCAAGCGGCTGGCTAACTCCAAGGCCCACACGTCACGCTTCAT CAGTGCCAATCTGCCTTGTAACAAGTTCAAGAACCGCCTGGTGAACATCATGCCCTATGAGAGCACACGGGTCTGTCTGCAACCCATCCGGGGTGTGGAG GGCTCTGACTACATCAACGCCAGCTTCATTGATGGCTACAGGCAGCAGAAGGCCTACATCGCGACACAGGGGCCGCTGGCGGAGACCACGGAAGACTTCT GGCGCATGCTGTGGGAGAACAATTCGACGATCGTGGTGATGCTGACCAAGCTGCGGGAGATGGGCCGGGAGAAGTGTCACCAGTACTGGCCGGCCGAGCG CTCTGCCCGCTACCAGTACTTTGTGGTAGATCCGATGGCAGAATACAACATGCCTCAGTATATCCTGCGAGAGTTCAAGGTCACAGATGCCCGGGATGGC CAGTCCCGGACTGTCCGGCAGTTCCAGTTCACAGACTGGCCGGAACAGGGTGTGCCAAAGTCGGGGGAGGGCTTCATCGACTTCATTGGCCAAGTGCATA AGACTAAGGAGCAGTTTGGCCAGGACGGCCCCATCTCTGTCCACTGCAGTGCCGGCGTGGGCAGGACGGGCGTCTTCATCACGCTTAGCATCGTGCTGGA GCGGATGCGGTATGAAGGCGTGGTGGACATCTTTCAGACGGTGAAGATGCTACGAACCCAGCGGCCGGCCATGGTGCAGACAGAGGATGAGTACCAGTTC TGTTACCAGGCGGCACTGGAGTACCTCGGAAGCTTTGACCACTATGCAACCTAAAGCCATGGTTCCCCCCAGGCCCGACACCACTGGCCCCGGATGCCTC TGCCCCTCCCGGGCGGACCTCCTGAGGCCTGGACCCCCAGTGGGCAGGGCAGGAGGTGGCAGCGGCAGCAGCTGTGTTTCTGCACCATTTCCGAGGACGA CGCAGCCCCTCGAGCCCCCCCACCGGCCCCGGCCGCCCCAGCGACCTCCCTGGCACCGGCCGCCGCCTTCAAATACTTGGCACATTCCTCCTTTCCTTCC AATTCCAAAACCAGATTCCGGGGTGGGGGGTGGGGGGATGGTGAGCAAATAGGAGTGCTCCCCAGAACCAGAGGAGGGTGGGGCACAGACCATAGACGGA CCCCTCGTCCTCCCCCAGCGGTGGTAGGGGGACCCGGGGGGCTCCTCCCCGCTCTGCAGC

refseq_PTPRS.F2 (forward primer)
refseq_PTPRS.R2 (reverse primer)
Single exon skipping

Frame 0

IPSHHPMILPHCPMTSPRRTLPCSM*PSLCLLH EGLLDFPTRLSQPSIVSADVAPSDARLEASL*GT GGPSPSRAEIGGRCQAWRPPGALAWCLWLVPWA SLWSCSLEAVQQKSPPGLSKNPRTRSACRGVWP LSCVRPRVTPSHE*PGTRRARRSTLSALRRLSLM RVQGQC*GSSR*GHRGMKTCTSVWPRTRLGRSQ SMPSLLSSERTSCPLASPTSTWAHS*RWWSGHG QPPCSVQPAATLTLRSPGSRTSCLWILVPAMDAS NSCDQEPCRLKAVRKPTRANMSVWPPTAPACAT PHLPTSTCESAAWPRASPSCP*ATRSCQGAT*T SPAWPWARPCHT*SGCRGPRT*PPRMTCPWVGTC WNSQMSRTRPTTPAWPCPAWASLRRLLRSR*NL SPKLPGLPW*LRTQPPASPSRGTRATQILCPIT SSNINPRAKTGRIRLKRTSPPHVTASAA*APTRS TRSGCRPSTPSARGPPASPWSPAQASRPRPARR GTCKPGCSARPP*LCSGRSRWSPTA*SAATAST TPWNRSTPWATGRSTTWTTAC*PPWAACWRTRPT PCGCSPSPPSATGPSRTPSRSRRSRECRASP*T CGPRPGRRPASRCPGAPRGRRVSSSTSSSSGKA TMAGRWEGPSTRRLPTWWRT*SPTRSTPSAWRPA RRRAWAPSPPWCGSARCSPSRPRTSR*K*S*RH QFCSAGSSLTTTTHPHPTRSSTMGSHWMWMAVP PRSSSRTSSPTPSTTLC*PIAAAAWAASSRRSPP GLPSTCSTASPASPPSLMLTASSWCIFLTARAP CLSRAISL*WCHCASLVEANS*PRWVAQRTWIW KSSSRTSHGYRGAACGTRVSWRCPGPILQLASLC CHPRSIPATRSSMAASITGAWSPATAMSSSCLP CFRRASLPLQPVPSQTPSSWITRTPSPSWMARR GLSG*SGLCWPWSS*SALSLLSCSTRTNPTVNAR TQNPAPNAS*TMPTSPLTTPRTLWK*DALTSRL QACLATRQFPSQTWRSTRSGSRPTTASSSPRSM SPSTLDSSSHGNIPTWK*TSRRTAMPTSSPMTTP VSSSSPLKASWAVITSMPTTWTATGVRTRTLPR RGRCLRPLGTSGVWCGSSGRRPSS**RGWRRSH GSSVISIGPTEARRPTASSRSRC*IPSSWPHSAS GHSLCTRMAPVRNARSASSSLRRGRTMACPNTQ RPSWLSCGESRPATRQMPAPSWFTAVPVWAAQA ALSSSTPCLSGSSQRRQSMSMAT*RS*GPSATTW CRRRTSTASSTRPCWRPWAVATQKCPHAASMPT SRSWPRWSLANTSLAWNSSSSGWLTPRPTRHAS SVPICLVTSSRTAW*TSCPMRAHGSVCNPSGVWR ALTTSTPASLMATGSRRPTSRHRGRWRRPRKTS GACCGRTIRRSW*C*PSCGRWAGRSVTSTGRPS ALPATSTLW*IRWQNTTCLSISCESSRSQMPGMA SPGLSGSSSSQTGRNRVCQSRGRASSTSLAKCI RLRSSLARTAPSLSTAVPAWAGRASSSRLASCW SGCGMKAWWTSFRR*RCYEPSGRPWCRQRMSTSS VTRRHWSTSEALTTMQPKAMVPPRPDTTGPGCL CPSRADLLRPGPPVGRAGGGSGSSCVSAPFPRT TQPLEPPHRPRPPQRPPWHRPPPSNTWHIPPFLP IPKPDSGVGGGGMVSK*ECSPEPEEGGAQTIDG PLVLPQRW*GDPGGSSPLCS

Frame 1

FHPITP*SFPIVP*PAPAGPSPAPCDPPSASSM KVSWISPLASHSPPLSLQTLPHLTLGSRPLCEG PGGHPPPGRRSEVAAKHGAHLGPWHGVCGWSHGP PCGPARWRLCSRRAPQVYQRTQGPDRRVGGCGL FRVSGHG*PQATSDLEQEGQEGQLSAL*DD*V* *ECRGSAEDPAAEDTAG*KRVRVCGPELGWGDHS PCQAYCPPRGPAALWLPQHRHGPTVEGGGADTD SHHALCSQRQP*P*DHLVQGLPACGS*CQQWTH QTAAIRSPAD*KQ*GNRPGQI*VCGHQQRRRALL LTCQPLRASPPRGPALLHPAHEPRDHARGQREH HLRGRGLAHAIREVDAGGRGPDPRG*HARGSER AGTHRCQGLGQLHLRGHVQPGRH*GGCSDHGEIS PQSSRDSHGD*EHSHQHHHHVGLGQPRSCVLLR HRI*IQEPRRAVSD*RGHHHHTLQHRRPEPQLG VRDLGVGRQLHRPGAPQRVRGHPHRRAGPGQRAA ERASPDAQRDHHDCAVGGAGGAQRPDPRLPRLL HHGTGAPRGQLAEAQRGRQPADHRGQPAGGRDL HRAGARLHLRRRRAPLGPHPGQDAAGSAGPAHEP AGRGQVGDQHHAVLEPPAAGEYHQVRAPLPGRR PWPGGGKDLRPDDFLRGGGPEAQHGVRLPPGGP LAAGPGRLHPRGAAAHAAVHLAQELQGENDHEDI SSAQLGVP*QLQLTHTLQDPVQWAHTGCGWPYH QEAHHAPQAPHLLQLCADQSRQQPGRPPADGHR LDCLQPAQRQAQRRPQA*C*RLHHGVSS*RPEPR ACPELFHCDGATAQVSWRPIPDPAG*PRGHGSG RAHPGHLTATEAQPAALASAGGAPALYCSSLLC AATHVPSRRPEAVWRLR*PGPGARPPLCPLRACR ASEERAYLCSQSLLRPLPAG*PGPPAHRGWRGG AYLGDRACAGRGLHNLHCHCYPALQEQTRQ*TQ GLRTPHQMPPEQCRPRPSPPQGPCGNETH*LPDS RHA*PPANSHRRHGGAHGAAQGQRQPQALPGV* VHRPWTAVHMGTFQPGSEQAEEPLCQRHRL*PL PCHPPAH*RHHGQ*LHQCQLRGRLPVSERVHCHA GAAA*DLWGLLAYGVGAAVGDHRHDDAAGGEVT DQV*SVLAQQRHGDLRLHPGHVARYHRAGHILR QDILSAQEWLQ*ETRGPPVPVYGVAGPWRARIPN ALPGFPAESQDLQPARCRPHRGSLQCRCGPHRL LYRHRRHA*ADQAREDSRCLWPRDAHEVPAQLH GADGGPVQLHPRGPAGGRGLWQHRSARTQPLCLH PEAGPGGAWRTRHWHGTRVQAAG*LQGPHVTLH QCQSAL*QVQEPPGEHHAL*EHTGLSATHPGCG GL*LHQRQLH*WLQAAEGLHRDTGAAGGDHGRLL AHAVGEQFDDRGDADQAAGDGPGEVSPVLAGRA LCPLPVLCGRSDGRIQHASVYPARVQGHRCPGW PVPDCPAVPVHRLAGTGCAKVGGGLHRLHWPSA* D*GAVWPGRPHLCPLQCRRGQDGRLHHA*HRAG ADAV*RRGGHLSDGEDATNPAAGHGADRG*VPV LLPGGTGVPRKL*PLCNLKPWFPPGPTPLAPDAS APPGRTS*GLDPQWAGQEVAAAAAVFLHHFRGR RSPSSPPTGPGRPSDLPGTGRRLQILGTFLLSF QFQNQIPGWGVGGW*ANRSAPQNQRRVGHRP*TD PSSSPSGGRGTRGAPPRSA

Frame 2

SIPSPHDPSPLSHDQPPQDPPLLHVTLPLPPP* RSPGFPHSPLTALHCLCRRCPI*RSARGLSVRD RGAIPLQGGDRRSLPSMAPTWGPGMVSVVGPMG LLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVAS FVCQATGDPKPRVTWNKKGKKVNSQRFETIEFD ESAGAVLRIQPLRTPRDENVYECVAQNSVGEIT VHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRT ATMLCAASGNPDPEITWFKDFLPVDPSASNGRI KQLRSGALQIESSEETDQGKYECVATNSAGVRY SSPANLYVRVRRVAPRFSILPMSHEIMPGGNVNI TCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNV LELTDVKDSANYTCVAMSSLGVIEAVAQITVKS LPKAPGTPMVTENTATSITITWDSGNPDPVSYYV IEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSE YEIWVSAVNSIGQGPPSESVVTRTGEQAPASAP RNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYY TMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETY TVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMN LRAEARSETSITLSWSPPRQESIIKYELLFREGD HGREVGRTFDPTTSYVVEDLKPNTEYAFRLAAR SPQGLGAFTPVVRQRTLQSISPKNFKVKMIMKT SVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTT KKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTA WTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSP VPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLE ELIQDISRLQRRSLRHSRQLEVPRPYIAARFSV LPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLA VLQKSEPTFAASPFSDPFQLDNPDPQPIVDGEEG LIWVIGPVLAVVFIICIVIAILLYKNKPDSKRK DSEPRTKCLLNNADLAPHHPKDPVEMRRINFQT PGMLSHPPIPIADMAEHTERLKANDSLKLSQEYE SIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHS RVILQPIEGIMGSDYINANYVDGYRCQNAYIAT QGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSR IKCDQYWPNRGTETYGFIQVTLLDTIELATFCV RTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYP TPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGC FIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYM VQTEDQYSFIHEALLEAVGCGNTEVPARSLYAY IQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFI SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVE GSDYINASFIDGYRQQKAYIATQGPLAETTEDF WRMLWENNSTIVVMLTKLREMGREKCHQYWPAER SARYQYFVVDPMAEYNMPQYILREFKVTDARDG QSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVH KTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLE RMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQF CYQAALEYLGSFDHYAT*SHGSPQARHHWPRMP LPLPGGPPEAWTPSGQGRRWQRQQLCFCTISEDD AAPRAPPPAPAAPATSLAPAAAFKYLAHSSFPS NSKTRFRGGGWGDGEQIGVLPRTRGGWGTDHRR TPRPPPAVVGGPGGLLPALQ

Sequence NM_130855

ATTCCATCCCATCACCCCATGATCCTTCCCCATTGTCCCATGACCAGCCCCCGCAGGACCCTCCCCTGCTCCATGTGACCCTCCCTCTGCCTCCTCCATG AAGGTCTCCTGGATTTCCCCACTCGCCTCTCACAGCCCTCCATTGTCTCTGCAGACGTTGCCCCATCTGACGCTCGGCTCGAGGCCTCTCTGTGAGGGAC CGGGGGGCCATCCCCCTCCAGGGCGGAGATCGGAGGTCGCTGCCAAGCATGGCGCCCACCTGGGGCCCTGGCATGGTGTCTGTGGTTGGTCCCATGGGCC TCCTTGTGGTCCTGCTCGTTGGAGGCTGTGCAGCAGAAGAGCCCCCCAGGTTTATCAAAGAACCCAAGGACCAGATCGGCGTGTCGGGGGGTGTGGCCTC TTTCGTGTGTCAGGCCACGGGTGACCCCAAGCCACGAGTGACCTGGAACAAGAAGGGCAAGAAGGTCAACTCTCAGCGCTTTGAGACGATTGAGTTTGAT GAGAGTGCAGGGGCAGTGCTGAGGATCCAGCCGCTGAGGACACCGCGGGATGAAAACGTGTACGAGTGTGTGGCCCAGAACTCGGTTGGGGAGATCACAG TCCATGCCAAGCTTACTGTCCTCCGAGAGGACCAGCTGCCCTCTGGCTTCCCCAACATCGACATGGGCCCACAGTTGAAGGTGGTGGAGCGGACACGGAC AGCCACCATGCTCTGTGCAGCCAGCGGCAACCCTGACCCTGAGATCACCTGGTTCAAGGACTTCCTGCCTGTGGATCCTAGTGCCAGCAATGGACGCATC AAACAGCTGCGATCAGGAGCCCTGCAGATTGAAAGCAGTGAGGAAACCGACCAGGGCAAATATGAGTGTGTGGCCACCAACAGCGCCGGCGTGCGCTACT CCTCACCTGCCAACCTCTACGTGCGAGAGCTTCGAGAAGTCCGCCGCGTGGCCCCGCGCTTCTCCATCCTGCCCATGAGCCACGAGATCATGCCAGGGGG CAACGTGAACATCACCTGCGTGGCCGTGGGCTCGCCCATGCCATACGTGAAGTGGATGCAGGGGGCCGAGGACCTGACCCCCGAGGATGACATGCCCGTG GGTCGGAACGTGCTGGAACTCACAGATGTCAAGGACTCGGCCAACTACACCTGCGTGGCCATGTCCAGCCTGGGCGTCATTGAGGCGGTTGCTCAGATCA CGGTGAAATCTCTCCCCAAAGCTCCCGGGACTCCCATGGTGACTGAGAACACAGCCACCAGCATCACCATCACGTGGGACTCGGGCAACCCAGATCCTGT GTCCTATTACGTCATCGAATATAAATCCAAGAGCCAAGACGGGCCGTATCAGATTAAAGAGGACATCACCACCACACGTTACAGCATCGGCGGCCTGAGC CCCAACTCGGAGTACGAGATCTGGGTGTCGGCCGTCAACTCCATCGGCCAGGGGCCCCCCAGCGAGTCCGTGGTCACCCGCACAGGCGAGCAGGCCCCGG CCAGCGCGCCGCGGAACGTGCAAGCCCGGATGCTCAGCGCGACCACCATGATTGTGCAGTGGGAGGAGCCGGTGGAGCCCAACGGCCTGATCCGCGGCTA CCGCGTCTACTACACCATGGAACCGGAGCACCCCGTGGGCAACTGGCAGAAGCACAACGTGGACGACAGCCTGCTGACCACCGTGGGCAGCCTGCTGGAG GACGAGACCTACACCGTGCGGGTGCTCGCCTTCACCTCCGTCGGCGACGGGCCCCTCTCGGACCCCATCCAGGTCAAGACGCAGCAGGGAGTGCCGGGCC AGCCCATGAACCTGCGGGCCGAGGCCAGGTCGGAGACCAGCATCACGCTGTCCTGGAGCCCCCCGCGGCAGGAGAGTATCATCAAGTACGAGCTCCTCTT CCGGGAAGGCGACCATGGCCGGGAGGTGGGAAGGACCTTCGACCCGACGACTTCCTACGTGGTGGAGGACCTGAAGCCCAACACGGAGTACGCCTTCCGC CTGGCGGCCCGCTCGCCGCAGGGCCTGGGCGCCTTCACCCCCGTGGTGCGGCAGCGCACGCTGCAGTCCATCTCGCCCAAGAACTTCAAGGTGAAAATGA TCATGAAGACATCAGTTCTGCTCAGCTGGGAGTTCCCTGACAACTACAACTCACCCACACCCTACAAGATCCAGTACAATGGGCTCACACTGGATGTGGA TGGCCGTACCACCAAGAAGCTCATCACGCACCTCAAGCCCCACACCTTCTACAACTTTGTGCTGACCAATCGCGGCAGCAGCCTGGGCGGCCTCCAGCAG ACGGTCACCGCCTGGACTGCCTTCAACCTGCTCAACGGCAAGCCCAGCGTCGCCCCCAAGCCTGATGCTGACGGCTTCATCATGGTGTATCTTCCTGACG GCCAGAGCCCCGTGCCTGTCCAGAGCTATTTCATTGTGATGGTGCCACTGCGCAAGTCTCGTGGAGGCCAATTCCTGACCCCGCTGGGTAGCCCAGAGGA CATGGATCTGGAAGAGCTCATCCAGGACATCTCACGGCTACAGAGGCGCAGCCTGCGGCACTCGCGTCAGCTGGAGGTGCCCCGGCCCTATATTGCAGCT CGCTTCTCTGTGCTGCCACCCACGTTCCATCCCGGCGACCAGAAGCAGTATGGCGGCTTCGATAACCGGGGCCTGGAGCCCGGCCACCGCTATGTCCTCT TCGTGCTTGCCGTGCTTCAGAAGAGCGAGCCTACCTTTGCAGCCAGTCCCTTCTCAGACCCCTTCCAGCTGGATAACCCGGACCCCCAGCCCATCGTGGA TGGCGAGGAGGGGCTTATCTGGGTGATCGGGCCTGTGCTGGCCGTGGTCTTCATAATCTGCATTGTCATTGCTATCCTGCTCTACAAGAACAAACCCGAC AGTAAACGCAAGGACTCAGAACCCCGCACCAAATGCCTCCTGAACAATGCCGACCTCGCCCCTCACCACCCCAAGGACCCTGTGGAAATGAGACGCATTA ACTTCCAGACTCCAGGCATGCTTAGCCACCCGCCAATTCCCATCGCAGACATGGCGGAGCACACGGAGCGGCTCAAGGCCAACGACAGCCTCAAGCTCTC CCAGGAGTATGAGTCCATCGACCCTGGACAGCAGTTCACATGGGAACATTCCAACCTGGAAGTGAACAAGCCGAAGAACCGCTATGCCAACGTCATCGCC TATGACCACTCCCGTGTCATCCTCCAGCCCATTGAAGGCATCATGGGCAGTGATTACATCAATGCCAACTACGTGGACGGCTACCGGTGTCAGAACGCGT ACATTGCCACGCAGGGGCCGCTGCCTGAGACCTTTGGGGACTTCTGGCGTATGGTGTGGGAGCAGCGGTCGGCGACCATCGTCATGATGACGCGGCTGGA GGAGAAGTCACGGATCAAGTGTGATCAGTATTGGCCCAACAGAGGCACGGAGACCTACGGCTTCATCCAGGTCACGTTGCTAGATACCATCGAGCTGGCC ACATTCTGCGTCAGGACATTCTCTCTGCACAAGAATGGCTCCAGTGAGAAACGCGAGGTCCGCCAGTTCCAGTTTACGGCGTGGCCGGACCATGGCGTGC CCGAATACCCAACGCCCTTCCTGGCTTTCCTGCGGAGAGTCAAGACCTGCAACCCGCCAGATGCCGGCCCCATCGTGGTTCACTGCAGTGCCGGTGTGGG CCGCACAGGCTGCTTTATCGTCATCGACGCCATGCTTGAGCGGATCAAGCCAGAGAAGACAGTCGATGTCTATGGCCACGTGACGCTCATGAGGTCCCAG CGCAACTACATGGTGCAGACGGAGGACCAGTACAGCTTCATCCACGAGGCCCTGCTGGAGGCCGTGGGCTGTGGCAACACAGAAGTGCCCGCACGCAGCC TCTATGCCTACATCCAGAAGCTGGCCCAGGTGGAGCCTGGCGAACACGTCACTGGCATGGAACTCGAGTTCAAGCGGCTGGCTAACTCCAAGGCCCACAC GTCACGCTTCATCAGTGCCAATCTGCCTTGTAACAAGTTCAAGAACCGCCTGGTGAACATCATGCCCTATGAGAGCACACGGGTCTGTCTGCAACCCATC CGGGGTGTGGAGGGCTCTGACTACATCAACGCCAGCTTCATTGATGGCTACAGGCAGCAGAAGGCCTACATCGCGACACAGGGGCCGCTGGCGGAGACCA CGGAAGACTTCTGGCGCATGCTGTGGGAGAACAATTCGACGATCGTGGTGATGCTGACCAAGCTGCGGGAGATGGGCCGGGAGAAGTGTCACCAGTACTG GCCGGCCGAGCGCTCTGCCCGCTACCAGTACTTTGTGGTAGATCCGATGGCAGAATACAACATGCCTCAGTATATCCTGCGAGAGTTCAAGGTCACAGAT GCCCGGGATGGCCAGTCCCGGACTGTCCGGCAGTTCCAGTTCACAGACTGGCCGGAACAGGGTGTGCCAAAGTCGGGGGAGGGCTTCATCGACTTCATTG GCCAAGTGCATAAGACTAAGGAGCAGTTTGGCCAGGACGGCCCCATCTCTGTCCACTGCAGTGCCGGCGTGGGCAGGACGGGCGTCTTCATCACGCTTAG CATCGTGCTGGAGCGGATGCGGTATGAAGGCGTGGTGGACATCTTTCAGACGGTGAAGATGCTACGAACCCAGCGGCCGGCCATGGTGCAGACAGAGGAT GAGTACCAGTTCTGTTACCAGGCGGCACTGGAGTACCTCGGAAGCTTTGACCACTATGCAACCTAAAGCCATGGTTCCCCCCAGGCCCGACACCACTGGC CCCGGATGCCTCTGCCCCTCCCGGGCGGACCTCCTGAGGCCTGGACCCCCAGTGGGCAGGGCAGGAGGTGGCAGCGGCAGCAGCTGTGTTTCTGCACCAT TTCCGAGGACGACGCAGCCCCTCGAGCCCCCCCACCGGCCCCGGCCGCCCCAGCGACCTCCCTGGCACCGGCCGCCGCCTTCAAATACTTGGCACATTCC TCCTTTCCTTCCAATTCCAAAACCAGATTCCGGGGTGGGGGGTGGGGGGATGGTGAGCAAATAGGAGTGCTCCCCAGAACCAGAGGAGGGTGGGGCACAG ACCATAGACGGACCCCTCGTCCTCCCCCAGCGGTGGTAGGGGGACCCGGGGGGCTCCTCCCCGCTCTGCAGC

refseq_PTPRS.F2 (forward primer)
refseq_PTPRS.R2 (reverse primer)
Single exon skipping

Frame 0

IPSHHPMILPHCPMTSPRRTLPCSM*PSLCLLH EGLLDFPTRLSQPSIVSADVAPSDARLEASL*GT GGPSPSRAEIGGRCQAWRPPGALAWCLWLVPWA SLWSCSLEAVQQKSPPGLSKNPRTRSACRGVWP LSCVRPRVTPSHE*PGTRRARRSTLSALRRLSLM RVQGQC*GSSR*GHRGMKTCTSVWPRTRLGRSQ SMPSLLSSERTSCPLASPTSTWAHS*RWWSGHG QPPCSVQPAATLTLRSPGSRTSCLWILVPAMDAS NSCDQEPCRLKAVRKPTRANMSVWPPTAPACAT PHLPTSTCESFEKSAAWPRASPSCP*ATRSCQG AT*TSPAWPWARPCHT*SGCRGPRT*PPRMTCPW VGTCWNSQMSRTRPTTPAWPCPAWASLRRLLRS R*NLSPKLPGLPW*LRTQPPASPSRGTRATQIL CPITSSNINPRAKTGRIRLKRTSPPHVTASAA*A PTRSTRSGCRPSTPSARGPPASPWSPAQASRPR PARRGTCKPGCSARPP*LCSGRSRWSPTA*SAA TASTTPWNRSTPWATGRSTTWTTAC*PPWAACWR TRPTPCGCSPSPPSATGPSRTPSRSRRSRECRA SP*TCGPRPGRRPASRCPGAPRGRRVSSSTSSS SGKATMAGRWEGPSTRRLPTWWRT*SPTRSTPSA WRPARRRAWAPSPPWCGSARCSPSRPRTSR*K* S*RHQFCSAGSSLTTTTHPHPTRSSTMGSHWMW MAVPPRSSSRTSSPTPSTTLC*PIAAAAWAASSR RSPPGLPSTCSTASPASPPSLMLTASSWCIFLT ARAPCLSRAISL*WCHCASLVEANS*PRWVAQR TWIWKSSSRTSHGYRGAACGTRVSWRCPGPILQL ASLCCHPRSIPATRSSMAASITGAWSPATAMSS SCLPCFRRASLPLQPVPSQTPSSWITRTPSPSW MARRGLSG*SGLCWPWSS*SALSLLSCSTRTNPT VNARTQNPAPNAS*TMPTSPLTTPRTLWK*DAL TSRLQACLATRQFPSQTWRSTRSGSRPTTASSS PRSMSPSTLDSSSHGNIPTWK*TSRRTAMPTSSP MTTPVSSSSPLKASWAVITSMPTTWTATGVRTR TLPRRGRCLRPLGTSGVWCGSSGRRPSS**RGW RRSHGSSVISIGPTEARRPTASSRSRC*IPSSWP HSASGHSLCTRMAPVRNARSASSSLRRGRTMAC PNTQRPSWLSCGESRPATRQMPAPSWFTAVPVW AAQAALSSSTPCLSGSSQRRQSMSMAT*RS*GPS ATTWCRRRTSTASSTRPCWRPWAVATQKCPHAA SMPTSRSWPRWSLANTSLAWNSSSSGWLTPRPT RHASSVPICLVTSSRTAW*TSCPMRAHGSVCNPS GVWRALTTSTPASLMATGSRRPTSRHRGRWRRP RKTSGACCGRTIRRSW*C*PSCGRWAGRSVTST GRPSALPATSTLW*IRWQNTTCLSISCESSRSQM PGMASPGLSGSSSSQTGRNRVCQSRGRASSTSL AKCIRLRSSLARTAPSLSTAVPAWAGRASSSRL ASCWSGCGMKAWWTSFRR*RCYEPSGRPWCRQRM STSSVTRRHWSTSEALTTMQPKAMVPPRPDTTG PGCLCPSRADLLRPGPPVGRAGGGSGSSCVSAP FPRTTQPLEPPHRPRPPQRPPWHRPPPSNTWHIP PFLPIPKPDSGVGGGGMVSK*ECSPEPEEGGAQ TIDGPLVLPQRW*GDPGGSSPLCS

Frame 1

FHPITP*SFPIVP*PAPAGPSPAPCDPPSASSM KVSWISPLASHSPPLSLQTLPHLTLGSRPLCEG PGGHPPPGRRSEVAAKHGAHLGPWHGVCGWSHGP PCGPARWRLCSRRAPQVYQRTQGPDRRVGGCGL FRVSGHG*PQATSDLEQEGQEGQLSAL*DD*V* *ECRGSAEDPAAEDTAG*KRVRVCGPELGWGDHS PCQAYCPPRGPAALWLPQHRHGPTVEGGGADTD SHHALCSQRQP*P*DHLVQGLPACGS*CQQWTH QTAAIRSPAD*KQ*GNRPGQI*VCGHQQRRRALL LTCQPLRARASRSPPRGPALLHPAHEPRDHARG QREHHLRGRGLAHAIREVDAGGRGPDPRG*HAR GSERAGTHRCQGLGQLHLRGHVQPGRH*GGCSDH GEISPQSSRDSHGD*EHSHQHHHHVGLGQPRSC VLLRHRI*IQEPRRAVSD*RGHHHHTLQHRRPE PQLGVRDLGVGRQLHRPGAPQRVRGHPHRRAGPG QRAAERASPDAQRDHHDCAVGGAGGAQRPDPRL PRLLHHGTGAPRGQLAEAQRGRQPADHRGQPAG GRDLHRAGARLHLRRRRAPLGPHPGQDAAGSAGP AHEPAGRGQVGDQHHAVLEPPAAGEYHQVRAPL PGRRPWPGGGKDLRPDDFLRGGGPEAQHGVRLP PGGPLAAGPGRLHPRGAAAHAAVHLAQELQGEND HEDISSAQLGVP*QLQLTHTLQDPVQWAHTGCG WPYHQEAHHAPQAPHLLQLCADQSRQQPGRPPA DGHRLDCLQPAQRQAQRRPQA*C*RLHHGVSS*R PEPRACPELFHCDGATAQVSWRPIPDPAG*PRG HGSGRAHPGHLTATEAQPAALASAGGAPALYCS SLLCAATHVPSRRPEAVWRLR*PGPGARPPLCPL RACRASEERAYLCSQSLLRPLPAG*PGPPAHRG WRGGAYLGDRACAGRGLHNLHCHCYPALQEQTR Q*TQGLRTPHQMPPEQCRPRPSPPQGPCGNETH* LPDSRHA*PPANSHRRHGGAHGAAQGQRQPQAL PGV*VHRPWTAVHMGTFQPGSEQAEEPLCQRHR L*PLPCHPPAH*RHHGQ*LHQCQLRGRLPVSERV HCHAGAAA*DLWGLLAYGVGAAVGDHRHDDAAG GEVTDQV*SVLAQQRHGDLRLHPGHVARYHRAG HILRQDILSAQEWLQ*ETRGPPVPVYGVAGPWRA RIPNALPGFPAESQDLQPARCRPHRGSLQCRCG PHRLLYRHRRHA*ADQAREDSRCLWPRDAHEVP AQLHGADGGPVQLHPRGPAGGRGLWQHRSARTQP LCLHPEAGPGGAWRTRHWHGTRVQAAG*LQGPH VTLHQCQSAL*QVQEPPGEHHAL*EHTGLSATH PGCGGL*LHQRQLH*WLQAAEGLHRDTGAAGGDH GRLLAHAVGEQFDDRGDADQAAGDGPGEVSPVL AGRALCPLPVLCGRSDGRIQHASVYPARVQGHR CPGWPVPDCPAVPVHRLAGTGCAKVGGGLHRLHW PSA*D*GAVWPGRPHLCPLQCRRGQDGRLHHA* HRAGADAV*RRGGHLSDGEDATNPAAGHGADRG *VPVLLPGGTGVPRKL*PLCNLKPWFPPGPTPLA PDASAPPGRTS*GLDPQWAGQEVAAAAAVFLHH FRGRRSPSSPPTGPGRPSDLPGTGRRLQILGTF LLSFQFQNQIPGWGVGGW*ANRSAPQNQRRVGHR P*TDPSSSPSGGRGTRGAPPRSA

Frame 2

SIPSPHDPSPLSHDQPPQDPPLLHVTLPLPPP* RSPGFPHSPLTALHCLCRRCPI*RSARGLSVRD RGAIPLQGGDRRSLPSMAPTWGPGMVSVVGPMG LLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVAS FVCQATGDPKPRVTWNKKGKKVNSQRFETIEFD ESAGAVLRIQPLRTPRDENVYECVAQNSVGEIT VHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRT ATMLCAASGNPDPEITWFKDFLPVDPSASNGRI KQLRSGALQIESSEETDQGKYECVATNSAGVRY SSPANLYVRELREVRRVAPRFSILPMSHEIMPGG NVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPV GRNVLELTDVKDSANYTCVAMSSLGVIEAVAQI TVKSLPKAPGTPMVTENTATSITITWDSGNPDPV SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLS PNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAP ASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGY RVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLE DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPG QPMNLRAEARSETSITLSWSPPRQESIIKYELLF REGDHGREVGRTFDPTTSYVVEDLKPNTEYAFR LAARSPQGLGAFTPVVRQRTLQSISPKNFKVKM IMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVD GRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQ TVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPD GQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPED MDLEELIQDISRLQRRSLRHSRQLEVPRPYIAA RFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVL FVLAVLQKSEPTFAASPFSDPFQLDNPDPQPIVD GEEGLIWVIGPVLAVVFIICIVIAILLYKNKPD SKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRI NFQTPGMLSHPPIPIADMAEHTERLKANDSLKLS QEYESIDPGQQFTWEHSNLEVNKPKNRYANVIA YDHSRVILQPIEGIMGSDYINANYVDGYRCQNA YIATQGPLPETFGDFWRMVWEQRSATIVMMTRLE EKSRIKCDQYWPNRGTETYGFIQVTLLDTIELA TFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGV PEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVG RTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQ RNYMVQTEDQYSFIHEALLEAVGCGNTEVPARS LYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHT SRFISANLPCNKFKNRLVNIMPYESTRVCLQPI RGVEGSDYINASFIDGYRQQKAYIATQGPLAET TEDFWRMLWENNSTIVVMLTKLREMGREKCHQYW PAERSARYQYFVVDPMAEYNMPQYILREFKVTD ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFI GQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLS IVLERMRYEGVVDIFQTVKMLRTQRPAMVQTED EYQFCYQAALEYLGSFDHYAT*SHGSPQARHHW PRMPLPLPGGPPEAWTPSGQGRRWQRQQLCFCTI SEDDAAPRAPPPAPAAPATSLAPAAAFKYLAHS SFPSNSKTRFRGGGWGDGEQIGVLPRTRGGWGT DHRRTPRPPPAVVGGPGGLLPALQ

Sequence NM_002850

ATTCCATCCCATCACCCCATGATCCTTCCCCATTGTCCCATGACCAGCCCCCGCAGGACCCTCCCCTGCTCCATGTGACCCTCCCTCTGCCTCCTCCATG AAGGTCTCCTGGATTTCCCCACTCGCCTCTCACAGCCCTCCATTGTCTCTGCAGACGTTGCCCCATCTGACGCTCGGCTCGAGGCCTCTCTGTGAGGGAC CGGGGGGCCATCCCCCTCCAGGGCGGAGATCGGAGGTCGCTGCCAAGCATGGCGCCCACCTGGGGCCCTGGCATGGTGTCTGTGGTTGGTCCCATGGGCC TCCTTGTGGTCCTGCTCGTTGGAGGCTGTGCAGCAGAAGAGCCCCCCAGGTTTATCAAAGAACCCAAGGACCAGATCGGCGTGTCGGGGGGTGTGGCCTC TTTCGTGTGTCAGGCCACGGGTGACCCCAAGCCACGAGTGACCTGGAACAAGAAGGGCAAGAAGGTCAACTCTCAGCGCTTTGAGACGATTGAGTTTGAT GAGAGTGCAGGGGCAGTGCTGAGGATCCAGCCGCTGAGGACACCGCGGGATGAAAACGTGTACGAGTGTGTGGCCCAGAACTCGGTTGGGGAGATCACAG TCCATGCCAAGCTTACTGTCCTCCGAGAGGACCAGCTGCCCTCTGGCTTCCCCAACATCGACATGGGCCCACAGTTGAAGGTGGTGGAGCGGACACGGAC AGCCACCATGCTCTGTGCAGCCAGCGGCAACCCTGACCCTGAGATCACCTGGTTCAAGGACTTCCTGCCTGTGGATCCTAGTGCCAGCAATGGACGCATC AAACAGCTGCGATCAGAAACCTTTGAAAGCACTCCGATTCGAGGAGCCCTGCAGATTGAAAGCAGTGAGGAAACCGACCAGGGCAAATATGAGTGTGTGG CCACCAACAGCGCCGGCGTGCGCTACTCCTCACCTGCCAACCTCTACGTGCGAGAGCTTCGAGAAGTCCGCCGCGTGGCCCCGCGCTTCTCCATCCTGCC CATGAGCCACGAGATCATGCCAGGGGGCAACGTGAACATCACCTGCGTGGCCGTGGGCTCGCCCATGCCATACGTGAAGTGGATGCAGGGGGCCGAGGAC CTGACCCCCGAGGATGACATGCCCGTGGGTCGGAACGTGCTGGAACTCACAGATGTCAAGGACTCGGCCAACTACACCTGCGTGGCCATGTCCAGCCTGG GCGTCATTGAGGCGGTTGCTCAGATCACGGTGAAATCTCTCCCCAAAGCTCCCGGGACTCCCATGGTGACTGAGAACACAGCCACCAGCATCACCATCAC GTGGGACTCGGGCAACCCAGATCCTGTGTCCTATTACGTCATCGAATATAAATCCAAGAGCCAAGACGGGCCGTATCAGATTAAAGAGGACATCACCACC ACACGTTACAGCATCGGCGGCCTGAGCCCCAACTCGGAGTACGAGATCTGGGTGTCGGCCGTCAACTCCATCGGCCAGGGGCCCCCCAGCGAGTCCGTGG TCACCCGCACAGGCGAGCAGGCCCCGGCCAGCGCGCCGCGGAACGTGCAAGCCCGGATGCTCAGCGCGACCACCATGATTGTGCAGTGGGAGGAGCCGGT GGAGCCCAACGGCCTGATCCGCGGCTACCGCGTCTACTACACCATGGAACCGGAGCACCCCGTGGGCAACTGGCAGAAGCACAACGTGGACGACAGCCTG CTGACCACCGTGGGCAGCCTGCTGGAGGACGAGACCTACACCGTGCGGGTGCTCGCCTTCACCTCCGTCGGCGACGGGCCCCTCTCGGACCCCATCCAGG TCAAGACGCAGCAGGGAGTGCCGGGCCAGCCCATGAACCTGCGGGCCGAGGCCAGGTCGGAGACCAGCATCACGCTGTCCTGGAGCCCCCCGCGGCAGGA GAGTATCATCAAGTACGAGCTCCTCTTCCGGGAAGGCGACCATGGCCGGGAGGTGGGAAGGACCTTCGACCCGACGACTTCCTACGTGGTGGAGGACCTG AAGCCCAACACGGAGTACGCCTTCCGCCTGGCGGCCCGCTCGCCGCAGGGCCTGGGCGCCTTCACCCCCGTGGTGCGGCAGCGCACGCTGCAGTCCAAAC CGTCAGCCCCCCCTCAAGACGTTAAATGTGTCAGCGTGCGCTCCACGGCCATTTTGGTAAGTTGGCGCCCGCCGCCGCCGGAAACGCACAACGGGGCCCT GGTGGGCTACAGCGTCCGCTACCGACCGCTGGGCTCAGAGGACCCGGAACCCAAGGAGGTGAACGGCATCCCCCCGACCACCACTCAGATCCTGCTGGAG GCCTTGGAGAAGTGGACCCAGTACCGCATCACGACTGTCGCTCACACAGAGGTGGGACCAGGGCCCGAGAGCTCGCCCGTGGTCGTCCGCACCGACGAGG ATGTGCCCAGCGCGCCGCCGCGGAAGGTGGAGGCGGAGGCGCTCAACGCCACGGCCATCCGCGTGCTGTGGCGCTCGCCCGCGCCCGGCCGGCAGCACGG CCAGATCCGCGGCTACCAGGTCCACTACGTGCGCATGGAGGGCGCCGAGGCCCGCGGGCCGCCGCGCATCAAGGACGTCATGCTGGCCGATGCCCAGTGG GAGACGGATGACACGGCCGAATATGAGATGGTCATCACAAACTTGCAGCCTGAGACCGCGTACTCCATCACGGTAGCCGCCTACACCATGAAGGGCGATG GCGCTCGCAGCAAACCCAAGGTGGTTGTGACCAAGGGAGCAGTGCTGGGCCGCCCAACCCTGTCGGTGCAGCAGACCCCCGAGGGCAGCCTGCTGGCACG CTGGGAGCCCCCGGCTGGCACCGCGGAGGACCAGGTGCTGGGCTACCGCCTGCAGTTTGGCCGTGAGGACTCGACGCCCCTGGCCACCCTGGAGTTCCCG CCCTCCGAGGACCGCTACACGGCATCAGGCGTGCACAAGGGGGCCACGTATGTGTTCCGGCTTGCGGCCCGGAGCCGCGGCGGCCTGGGCGAGGAGGCAG CCGAGGTCCTGAGCATCCCGGAGGACACGCCCCGTGGCCACCCGCAGATTCTGGAGGCGGCCGGCAACGCCTCGGCCGGGACCGTCCTTCTCCGCTGGCT GCCACCCGTGCCCGCCGAGCGCAACGGGGCCATCGTCAAATACACGGTGGCCGTGCGGGAGGCCGGTGCCCTGGGCCCTGCCCGAGAGACTGAGCTGCCG GCAGCGGCTGAGCCGGGCGCGGAGAACGCGCTCACGCTGCAGGGCCTGAAGCCCGACACGGCCTATGACCTCCAAGTGCGAGCCCACACGCGCCGGGGCC CTGGCCCCTTCAGCCCCCCCGTCCGCTACCGGACGTTCCTGCGGGACCAAGTCTCGCCCAAGAACTTCAAGGTGAAAATGATCATGAAGACATCAGTTCT GCTCAGCTGGGAGTTCCCTGACAACTACAACTCACCCACACCCTACAAGATCCAGTACAATGGGCTCACACTGGATGTGGATGGCCGTACCACCAAGAAG CTCATCACGCACCTCAAGCCCCACACCTTCTACAACTTTGTGCTGACCAATCGCGGCAGCAGCCTGGGCGGCCTCCAGCAGACGGTCACCGCCTGGACTG CCTTCAACCTGCTCAACGGCAAGCCCAGCGTCGCCCCCAAGCCTGATGCTGACGGCTTCATCATGGTGTATCTTCCTGACGGCCAGAGCCCCGTGCCTGT CCAGAGCTATTTCATTGTGATGGTGCCACTGCGCAAGTCTCGTGGAGGCCAATTCCTGACCCCGCTGGGTAGCCCAGAGGACATGGATCTGGAAGAGCTC ATCCAGGACATCTCACGGCTACAGAGGCGCAGCCTGCGGCACTCGCGTCAGCTGGAGGTGCCCCGGCCCTATATTGCAGCTCGCTTCTCTGTGCTGCCAC CCACGTTCCATCCCGGCGACCAGAAGCAGTATGGCGGCTTCGATAACCGGGGCCTGGAGCCCGGCCACCGCTATGTCCTCTTCGTGCTTGCCGTGCTTCA GAAGAGCGAGCCTACCTTTGCAGCCAGTCCCTTCTCAGACCCCTTCCAGCTGGATAACCCGGACCCCCAGCCCATCGTGGATGGCGAGGAGGGGCTTATC TGGGTGATCGGGCCTGTGCTGGCCGTGGTCTTCATAATCTGCATTGTCATTGCTATCCTGCTCTACAAGAACAAACCCGACAGTAAACGCAAGGACTCAG AACCCCGCACCAAATGCCTCCTGAACAATGCCGACCTCGCCCCTCACCACCCCAAGGACCCTGTGGAAATGAGACGCATTAACTTCCAGACTCCAGATTC AGGCCTCAGGAGCCCCCTCAGGGAGCCGGGGTTTCACTTTGAAAGCATGCTTAGCCACCCGCCAATTCCCATCGCAGACATGGCGGAGCACACGGAGCGG CTCAAGGCCAACGACAGCCTCAAGCTCTCCCAGGAGTATGAGTCCATCGACCCTGGACAGCAGTTCACATGGGAACATTCCAACCTGGAAGTGAACAAGC CGAAGAACCGCTATGCCAACGTCATCGCCTATGACCACTCCCGTGTCATCCTCCAGCCCATTGAAGGCATCATGGGCAGTGATTACATCAATGCCAACTA CGTGGACGGCTACCGGTGTCAGAACGCGTACATTGCCACGCAGGGGCCGCTGCCTGAGACCTTTGGGGACTTCTGGCGTATGGTGTGGGAGCAGCGGTCG GCGACCATCGTCATGATGACGCGGCTGGAGGAGAAGTCACGGATCAAGTGTGATCAGTATTGGCCCAACAGAGGCACGGAGACCTACGGCTTCATCCAGG TCACGTTGCTAGATACCATCGAGCTGGCCACATTCTGCGTCAGGACATTCTCTCTGCACAAGAATGGCTCCAGTGAGAAACGCGAGGTCCGCCAGTTCCA GTTTACGGCGTGGCCGGACCATGGCGTGCCCGAATACCCAACGCCCTTCCTGGCTTTCCTGCGGAGAGTCAAGACCTGCAACCCGCCAGATGCCGGCCCC ATCGTGGTTCACTGCAGTGCCGGTGTGGGCCGCACAGGCTGCTTTATCGTCATCGACGCCATGCTTGAGCGGATCAAGCCAGAGAAGACAGTCGATGTCT ATGGCCACGTGACGCTCATGAGGTCCCAGCGCAACTACATGGTGCAGACGGAGGACCAGTACAGCTTCATCCACGAGGCCCTGCTGGAGGCCGTGGGCTG TGGCAACACAGAAGTGCCCGCACGCAGCCTCTATGCCTACATCCAGAAGCTGGCCCAGGTGGAGCCTGGCGAACACGTCACTGGCATGGAACTCGAGTTC AAGCGGCTGGCTAACTCCAAGGCCCACACGTCACGCTTCATCAGTGCCAATCTGCCTTGTAACAAGTTCAAGAACCGCCTGGTGAACATCATGCCCTATG AGAGCACACGGGTCTGTCTGCAACCCATCCGGGGTGTGGAGGGCTCTGACTACATCAACGCCAGCTTCATTGATGGCTACAGGCAGCAGAAGGCCTACAT CGCGACACAGGGGCCGCTGGCGGAGACCACGGAAGACTTCTGGCGCATGCTGTGGGAGAACAATTCGACGATCGTGGTGATGCTGACCAAGCTGCGGGAG ATGGGCCGGGAGAAGTGTCACCAGTACTGGCCGGCCGAGCGCTCTGCCCGCTACCAGTACTTTGTGGTAGATCCGATGGCAGAATACAACATGCCTCAGT ATATCCTGCGAGAGTTCAAGGTCACAGATGCCCGGGATGGCCAGTCCCGGACTGTCCGGCAGTTCCAGTTCACAGACTGGCCGGAACAGGGTGTGCCAAA GTCGGGGGAGGGCTTCATCGACTTCATTGGCCAAGTGCATAAGACTAAGGAGCAGTTTGGCCAGGACGGCCCCATCTCTGTCCACTGCAGTGCCGGCGTG GGCAGGACGGGCGTCTTCATCACGCTTAGCATCGTGCTGGAGCGGATGCGGTATGAAGGCGTGGTGGACATCTTTCAGACGGTGAAGATGCTACGAACCC AGCGGCCGGCCATGGTGCAGACAGAGGATGAGTACCAGTTCTGTTACCAGGCGGCACTGGAGTACCTCGGAAGCTTTGACCACTATGCAACCTAAAGCCA TGGTTCCCCCCAGGCCCGACACCACTGGCCCCGGATGCCTCTGCCCCTCCCGGGCGGACCTCCTGAGGCCTGGACCCCCAGTGGGCAGGGCAGGAGGTGG CAGCGGCAGCAGCTGTGTTTCTGCACCATTTCCGAGGACGACGCAGCCCCTCGAGCCCCCCCACCGGCCCCGGCCGCCCCAGCGACCTCCCTGGCACCGG CCGCCGCCTTCAAATACTTGGCACATTCCTCCTTTCCTTCCAATTCCAAAACCAGATTCCGGGGTGGGGGGTGGGGGGATGGTGAGCAAATAGGAGTGCT CCCCAGAACCAGAGGAGGGTGGGGCACAGACCATAGACGGACCCCTCGTCCTCCCCCAGCGGTGGTAGGGGGACCCGGGGGGCTCCTCCCCGCTCTGCAG C

refseq_PTPRS.F2 (forward primer)
refseq_PTPRS.R2 (reverse primer)
Single exon skipping

Frame 0

IPSHHPMILPHCPMTSPRRTLPCSM*PSLCLLH EGLLDFPTRLSQPSIVSADVAPSDARLEASL*GT GGPSPSRAEIGGRCQAWRPPGALAWCLWLVPWA SLWSCSLEAVQQKSPPGLSKNPRTRSACRGVWP LSCVRPRVTPSHE*PGTRRARRSTLSALRRLSLM RVQGQC*GSSR*GHRGMKTCTSVWPRTRLGRSQ SMPSLLSSERTSCPLASPTSTWAHS*RWWSGHG QPPCSVQPAATLTLRSPGSRTSCLWILVPAMDAS NSCDQKPLKALRFEEPCRLKAVRKPTRANMSVW PPTAPACATPHLPTSTCESFEKSAAWPRASPSC P*ATRSCQGAT*TSPAWPWARPCHT*SGCRGPRT *PPRMTCPWVGTCWNSQMSRTRPTTPAWPCPAW ASLRRLLRSR*NLSPKLPGLPW*LRTQPPASPS RGTRATQILCPITSSNINPRAKTGRIRLKRTSPP HVTASAA*APTRSTRSGCRPSTPSARGPPASPW SPAQASRPRPARRGTCKPGCSARPP*LCSGRSR WSPTA*SAATASTTPWNRSTPWATGRSTTWTTAC *PPWAACWRTRPTPCGCSPSPPSATGPSRTPSR SRRSRECRASP*TCGPRPGRRPASRCPGAPRGR RVSSSTSSSSGKATMAGRWEGPSTRRLPTWWRT* SPTRSTPSAWRPARRRAWAPSPPWCGSARCSPN RQPPLKTLNVSACAPRPFW*VGARRRRKRTTGP WWATASATDRWAQRTRNPRR*TASPRPPLRSCWR PWRSGPSTASRLSLTQRWDQGPRARPWSSAPTR MCPARRRGRWRRRRSTPRPSACCGARPRPAGST ARSAATRSTTCAWRAPRPAGRRASRTSCWPMPSG RRMTRPNMRWSSQTCSLRPRTPSR*PPTP*RAM ALAANPRWL*PREQCWAAQPCRCSRPPRAACWH AGSPRLAPRRTRCWATACSLAVRTRRPWPPWSSR PPRTATRHQACTRGPRMCSGLRPGAAAAWARRQ PRS*ASRRTRPVATRRFWRRPATPRPGPSFSAG CHPCPPSATGPSSNTRWPCGRPVPWALPERLSCR QRLSRARRTRSRCRA*SPTRPMTSKCEPTRAGA LAPSAPPSATGRSCGTKSRPRTSR*K*S*RHQF CSAGSSLTTTTHPHPTRSSTMGSHWMWMAVPPRS SSRTSSPTPSTTLC*PIAAAAWAASSRRSPPGL PSTCSTASPASPPSLMLTASSWCIFLTARAPCL SRAISL*WCHCASLVEANS*PRWVAQRTWIWKSS SRTSHGYRGAACGTRVSWRCPGPILQLASLCCH PRSIPATRSSMAASITGAWSPATAMSSSCLPCF RRASLPLQPVPSQTPSSWITRTPSPSWMARRGLS G*SGLCWPWSS*SALSLLSCSTRTNPTVNARTQ NPAPNAS*TMPTSPLTTPRTLWK*DALTSRLQI QASGAPSGSRGFTLKACLATRQFPSQTWRSTRSG SRPTTASSSPRSMSPSTLDSSSHGNIPTWK*TS RRTAMPTSSPMTTPVSSSSPLKASWAVITSMPT TWTATGVRTRTLPRRGRCLRPLGTSGVWCGSSGR RPSS**RGWRRSHGSSVISIGPTEARRPTASSR SRC*IPSSWPHSASGHSLCTRMAPVRNARSASS SLRRGRTMACPNTQRPSWLSCGESRPATRQMPAP SWFTAVPVWAAQAALSSSTPCLSGSSQRRQSMS MAT*RS*GPSATTWCRRRTSTASSTRPCWRPWA VATQKCPHAASMPTSRSWPRWSLANTSLAWNSSS SGWLTPRPTRHASSVPICLVTSSRTAW*TSCPM RAHGSVCNPSGVWRALTTSTPASLMATGSRRPT SRHRGRWRRPRKTSGACCGRTIRRSW*C*PSCGR WAGRSVTSTGRPSALPATSTLW*IRWQNTTCLS ISCESSRSQMPGMASPGLSGSSSSQTGRNRVCQ SRGRASSTSLAKCIRLRSSLARTAPSLSTAVPAW AGRASSSRLASCWSGCGMKAWWTSFRR*RCYEP SGRPWCRQRMSTSSVTRRHWSTSEALTTMQPKA MVPPRPDTTGPGCLCPSRADLLRPGPPVGRAGGG SGSSCVSAPFPRTTQPLEPPHRPRPPQRPPWHR PPPSNTWHIPPFLPIPKPDSGVGGGGMVSK*EC SPEPEEGGAQTIDGPLVLPQRW*GDPGGSSPLCS

Frame 1

FHPITP*SFPIVP*PAPAGPSPAPCDPPSASSM KVSWISPLASHSPPLSLQTLPHLTLGSRPLCEG PGGHPPPGRRSEVAAKHGAHLGPWHGVCGWSHGP PCGPARWRLCSRRAPQVYQRTQGPDRRVGGCGL FRVSGHG*PQATSDLEQEGQEGQLSAL*DD*V* *ECRGSAEDPAAEDTAG*KRVRVCGPELGWGDHS PCQAYCPPRGPAALWLPQHRHGPTVEGGGADTD SHHALCSQRQP*P*DHLVQGLPACGS*CQQWTH QTAAIRNL*KHSDSRSPAD*KQ*GNRPGQI*VCG HQQRRRALLLTCQPLRARASRSPPRGPALLHPA HEPRDHARGQREHHLRGRGLAHAIREVDAGGRG PDPRG*HARGSERAGTHRCQGLGQLHLRGHVQPG RH*GGCSDHGEISPQSSRDSHGD*EHSHQHHHH VGLGQPRSCVLLRHRI*IQEPRRAVSD*RGHHH HTLQHRRPEPQLGVRDLGVGRQLHRPGAPQRVRG HPHRRAGPGQRAAERASPDAQRDHHDCAVGGAG GAQRPDPRLPRLLHHGTGAPRGQLAEAQRGRQP ADHRGQPAGGRDLHRAGARLHLRRRRAPLGPHPG QDAAGSAGPAHEPAGRGQVGDQHHAVLEPPAAG EYHQVRAPLPGRRPWPGGGKDLRPDDFLRGGGP EAQHGVRLPPGGPLAAGPGRLHPRGAAAHAAVQT VSPPSRR*MCQRALHGHFGKLAPAAAGNAQRGP GGLQRPLPTAGLRGPGTQGGERHPPDHHSDPAG GLGEVDPVPHHDCRSHRGGTRARELARGRPHRRG CAQRAAAEGGGGGAQRHGHPRAVALARARPAAR PDPRLPGPLRAHGGRRGPRAAAHQGRHAGRCPV GDG*HGRI*DGHHKLAA*DRVLHHGSRLHHEGRW RSQQTQGGCDQGSSAGPPNPVGAADPRGQPAGT LGAPGWHRGGPGAGLPPAVWP*GLDAPGHPGVP ALRGPLHGIRRAQGGHVCVPACGPEPRRPGRGGS RGPEHPGGHAPWPPADSGGGRQRLGRDRPSPLA ATRARRAQRGHRQIHGGRAGGRCPGPCPRD*AA GSG*AGRGERAHAAGPEARHGL*PPSASPHAPGP WPLQPPRPLPDVPAGPSLAQELQGENDHEDISS AQLGVP*QLQLTHTLQDPVQWAHTGCGWPYHQE AHHAPQAPHLLQLCADQSRQQPGRPPADGHRLDC LQPAQRQAQRRPQA*C*RLHHGVSS*RPEPRAC PELFHCDGATAQVSWRPIPDPAG*PRGHGSGRA HPGHLTATEAQPAALASAGGAPALYCSSLLCAAT HVPSRRPEAVWRLR*PGPGARPPLCPLRACRAS EERAYLCSQSLLRPLPAG*PGPPAHRGWRGGAY LGDRACAGRGLHNLHCHCYPALQEQTRQ*TQGLR TPHQMPPEQCRPRPSPPQGPCGNETH*LPDSRF RPQEPPQGAGVSL*KHA*PPANSHRRHGGAHGA AQGQRQPQALPGV*VHRPWTAVHMGTFQPGSEQA EEPLCQRHRL*PLPCHPPAH*RHHGQ*LHQCQL RGRLPVSERVHCHAGAAA*DLWGLLAYGVGAAV GDHRHDDAAGGEVTDQV*SVLAQQRHGDLRLHPG HVARYHRAGHILRQDILSAQEWLQ*ETRGPPVP VYGVAGPWRARIPNALPGFPAESQDLQPARCRP HRGSLQCRCGPHRLLYRHRRHA*ADQAREDSRCL WPRDAHEVPAQLHGADGGPVQLHPRGPAGGRGL WQHRSARTQPLCLHPEAGPGGAWRTRHWHGTRV QAAG*LQGPHVTLHQCQSAL*QVQEPPGEHHAL* EHTGLSATHPGCGGL*LHQRQLH*WLQAAEGLH RDTGAAGGDHGRLLAHAVGEQFDDRGDADQAAG DGPGEVSPVLAGRALCPLPVLCGRSDGRIQHASV YPARVQGHRCPGWPVPDCPAVPVHRLAGTGCAK VGGGLHRLHWPSA*D*GAVWPGRPHLCPLQCRR GQDGRLHHA*HRAGADAV*RRGGHLSDGEDATNP AAGHGADRG*VPVLLPGGTGVPRKL*PLCNLKP WFPPGPTPLAPDASAPPGRTS*GLDPQWAGQEV AAAAAVFLHHFRGRRSPSSPPTGPGRPSDLPGTG RRLQILGTFLLSFQFQNQIPGWGVGGW*ANRSA PQNQRRVGHRP*TDPSSSPSGGRGTRGAPPRSA

Frame 2

SIPSPHDPSPLSHDQPPQDPPLLHVTLPLPPP* RSPGFPHSPLTALHCLCRRCPI*RSARGLSVRD RGAIPLQGGDRRSLPSMAPTWGPGMVSVVGPMG LLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVAS FVCQATGDPKPRVTWNKKGKKVNSQRFETIEFD ESAGAVLRIQPLRTPRDENVYECVAQNSVGEIT VHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRT ATMLCAASGNPDPEITWFKDFLPVDPSASNGRI KQLRSETFESTPIRGALQIESSEETDQGKYECV ATNSAGVRYSSPANLYVRELREVRRVAPRFSILP MSHEIMPGGNVNITCVAVGSPMPYVKWMQGAED LTPEDDMPVGRNVLELTDVKDSANYTCVAMSSL GVIEAVAQITVKSLPKAPGTPMVTENTATSITIT WDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITT TRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESV VTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV EPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSL LTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQ VKTQQGVPGQPMNLRAEARSETSITLSWSPPRQE SIIKYELLFREGDHGREVGRTFDPTTSYVVEDL KPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSK PSAPPQDVKCVSVRSTAILVSWRPPPPETHNGAL VGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLE ALEKWTQYRITTVAHTEVGPGPESSPVVVRTDE DVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHG QIRGYQVHYVRMEGAEARGPPRIKDVMLADAQW ETDDTAEYEMVITNLQPETAYSITVAAYTMKGD GARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLAR WEPPAGTAEDQVLGYRLQFGREDSTPLATLEFP PSEDRYTASGVHKGATYVFRLAARSRGGLGEEA AEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWL PPVPAERNGAIVKYTVAVREAGALGPARETELP AAAEPGAENALTLQGLKPDTAYDLQVRAHTRRG PGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVL LSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKK LITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWT AFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPV QSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEEL IQDISRLQRRSLRHSRQLEVPRPYIAARFSVLP PTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQ KSEPTFAASPFSDPFQLDNPDPQPIVDGEEGLI WVIGPVLAVVFIICIVIAILLYKNKPDSKRKDS EPRTKCLLNNADLAPHHPKDPVEMRRINFQTPDS GLRSPLREPGFHFESMLSHPPIPIADMAEHTER LKANDSLKLSQEYESIDPGQQFTWEHSNLEVNK PKNRYANVIAYDHSRVILQPIEGIMGSDYINANY VDGYRCQNAYIATQGPLPETFGDFWRMVWEQRS ATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQ VTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQ FTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGP IVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDV YGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGC GNTEVPARSLYAYIQKLAQVEPGEHVTGMELEF KRLANSKAHTSRFISANLPCNKFKNRLVNIMPY ESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYI ATQGPLAETTEDFWRMLWENNSTIVVMLTKLRE MGREKCHQYWPAERSARYQYFVVDPMAEYNMPQ YILREFKVTDARDGQSRTVRQFQFTDWPEQGVPK SGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGV GRTGVFITLSIVLERMRYEGVVDIFQTVKMLRT QRPAMVQTEDEYQFCYQAALEYLGSFDHYAT*SH GSPQARHHWPRMPLPLPGGPPEAWTPSGQGRRW QRQQLCFCTISEDDAAPRAPPPAPAAPATSLAP AAAFKYLAHSSFPSNSKTRFRGGGWGDGEQIGVL PRTRGGWGTDHRRTPRPPPAVVGGPGGLLPALQ