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Sequences

Sequence NM_032943

AACAAGCGACCTGTTTGGCAAGGAATACAGCATCCTTCTGAGAGCCTCTTCTCGACACTATCCCACAGACCAGGACTTCCTCATGGGAAAGAGCACTTAG GATCTTGCTATCAGCTGCCCTAAACTTTTGCTGAGCCAAAATAAGACTTTGATGCAGAACTGAACAAGATATTTCATTTTTGTGTGTTTTAATCTTCCTG GTTGCAGTCTTAGTTGTTCAGCCCTGAGAATTTTGAGCCACATTTGTTGCTATTATTTTTGCATGCACTTTTCAAAATGATTGACTTAAGCTTCCTGACT GAAGAGGAACAAGAGGCCATCATGAAGGTTTTGCAGCGGGATGCTGCTCTGAAGAGGGCCGAAGAAGAGAGAGTCAGACATTTGCCTGAAAAAATTAAGG ATGACCAGCAGCTGAAGAATATGAGTGGCCAATGGTTTTATGAAGCCAAGGCAAAAAGGCACAGGGACAAAATCCATGGCGCAGATATCATCAGAGCATC TATGAGAAAGAAGAGGCCCCAGATAGCAGCTGAGCAGAGTAAAGACAGAGAAAATGGGGCAAAGGAAAGCTGGGTGAATAATGTCAACAAAGATGCTTTC CTTCCTCCAGAGCTGGCTGGCGTTGTAGAAGAGCCAGAAGAAGATGCAGCACCAGCAAGCCCGAGTTCCAGTGTGGTAAATCCAGCTTCCAGTGTGATTG ATATGTCCCAGGAAAACACAAGGAAACCAAATGTGTCTCCAGAGAAGAGGAAGAATCCGTTTAATAGCTCCAAGTTGCCAGAAGGTCACTCATCACAACA AACTAAAAATGAACAGTCAAAAAATGGAAGAACTGGTTTATTTCAGACTTCAAAAGAGGATGAATTGTCAGAGTCAAAAGAAAAGTCAACTGTCGCAGAT ACTTCAATCCAAAAGTTAGAGAAATCAAAGCAGACTTTGCCAGGCCTTTCAAATGGGTCCCAAATCAAGGCTCCAATCCCCAAAGCCAGGAAGATGATCT ACAAATCAACTGATTTAAACAAAGATGATAACCAGTCTTTTCCTAGACAAAGGACAGACTCCCTGAAAGCGAGAGGGGCTCCGAGAGGGATCCTCAAGCG CAACTCCAGTTCCAGTAGCACAGACTCAGAAACCCTTCGTTATAATCACAACTTTGAACCCAAAAGCAAAATTGTGTCACCTGGCCTAACCATCCATGAG AGAATTTCTGAGAAGGAGCATTCTTTAGAAGACAACTCTTCCCCAAACTCCCTGGAGCCATTAAAGCATGTGAGATTCTCTGCAGTGAAGGATGAGCTTC CACAGAGTCCTGGGCTAATCCATGGTCGGGAAGTAGGAGAATTTAGTGTTTTAGAATCTGACAGATTGAAAAATGGAATGGAAGATGCAGGGGACACAGA AGAGTTTCAGAGTGACCCTAAGCCTTCTCAATACAGAAAGCCTTCGCTTTTTCATCAATCAACCTCAAGCCCATATGTATCAAAAAGTGAAACACATCAG CCAATGACTTCTGGTTCTTTTCCAATTAATGGGCTGCATTCTCATTCAGAAGTTTTAACTGCAAGACCACAGTCTATGGAGAATTCACCAACCATCAATG AACCCAAAGATAAATCATCAGAATTAACAAGGCTTGAATCTGTATTACCCAGAAGCCCTGCTGATGAACTGTCTCATTGTGTTGAGCCTGAGCCATCTCA GGTGCCAGGTGGCAGTTCTAGAGACCGTCAGCAAGGTTCAGAAGAAGAACCCAGTCCTGTTTTGAAAACTTTGGAAAGGAGTGCCGCTAGGAAAATGCCT TCCAAAAGTCTAGAAGACATTTCATCAGATTCATCAAATCAAGCAAAAGTAGATAATCAGCCAGAAGAATTAGTGCGTAGTGCTGAAGATGATGAGAAAC CAGATCAGAAGCCAGTTACAAATGAATGCGTACCAAGAATTTCCACAGTGCCTACACAACCTGATAATCCATTTTCTCACCCTGACAAACTCAAAAGGAT GAGCAAGTCTGTTCCAGCATTTCTCCAAGATGAGGTGAGTGGCAGTGTGATGAGTGTTTATAGTGGAGACTTTGGCAATCTGGAAGTTAAAGGAAATATT CAGTTTGCAATTGAATATGTGGAGTCACTGAAGGAGTTGCATGTTTTTGTGGCCCAGTGTAAGGACTTAGCAGCAGCGGATGTAAAAAAACAGCGTTCAG ACCCATATGTAAAGGCCTATTTGCTACCAGACAAAGGCAAAATGGGCAAGAAGAAAACACTCGTAGTGAAGAAAACCTTGAATCCTGTGTATAACGAAAT ACTGCGGTATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAG GTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAG CAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAA GGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACA AGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTG TCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTC TACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATT TCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTT TCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATG TGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAA CATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGA CCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAG AAACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGT TAAAACAAGCCTCAAATGTATTTTAGTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCT GTATTTTTATGAGTTTATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATG TTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAAACCCTTAGAATAAAT TATCATTTGATTTAAATTGTATTAGAAAATTAGCGTGACTTCTCATTTTAAATAAAATATTTTAGGAATTCTAAACATCTAAA

refseq_SYTL2.F1 (forward primer)
refseq_SYTL2.R1 (reverse primer)
Single exon skipping

Sequence Tools

Translations

Frame 0

NKRPVWQGIQHPSESLFSTLSHRPGLPHGKEHL GSCYQLP*TFAEPK*DFDAELNKIFHFCVF*SSW LQS*LFSPENFEPHLLLLFLHALFKMIDLSFLT EEEQEAIMKVLQRDAALKRAEEERVRHLPEKIK DDQQLKNMSGQWFYEAKAKRHRDKIHGADIIRAS MRKKRPQIAAEQSKDRENGAKESWVNNVNKDAF LPPELAGVVEEPEEDAAPASPSSSVVNPASSVI DMSQENTRKPNVSPEKRKNPFNSSKLPEGHSSQQ TKNEQSKNGRTGLFQTSKEDELSESKEKSTVAD TSIQKLEKSKQTLPGLSNGSQIKAPIPKARKMI YKSTDLNKDDNQSFPRQRTDSLKARGAPRGILKR NSSSSSTDSETLRYNHNFEPKSKIVSPGLTIHE RISEKEHSLEDNSSPNSLEPLKHVRFSAVKDEL PQSPGLIHGREVGEFSVLESDRLKNGMEDAGDTE EFQSDPKPSQYRKPSLFHQSTSSPYVSKSETHQ PMTSGSFPINGLHSHSEVLTARPQSMENSPTIN EPKDKSSELTRLESVLPRSPADELSHCVEPEPSQ VPGGSSRDRQQGSEEEPSPVLKTLERSAARKMP SKSLEDISSDSSNQAKVDNQPEELVRSAEDDEK PDQKPVTNECVPRISTVPTQPDNPFSHPDKLKRM SKSVPAFLQDEVSGSVMSVYSGDFGNLEVKGNI QFAIEYVESLKELHVFVAQCKDLAAADVKKQRS DPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEI LRYKIEKQILKTQKLNLSIWHRDTFKRNSFLGE VELDLETWDWDNKQNKQLRWYPLKRKTAPVALE AENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVK ECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKT RAVGKTTNPIFNHTMVYDGFRPEDLMEACVELT VWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDS TSEEVALWEKMVNSPNTWIEATLPLRMLLIAKI SK*AQIPLAPPLKTTKPVESDLENLSRWTNILT FYLLHLRNTTQHVKVNLHVLL*LQGPRDLNITKC VICDSNIK*DI*TS*EN*ISAAASKKKLPQSIK HGVLLRSKMFLFAIMCFTPQFCATVKRVWYPCR TFVGCGKKSQKDTQSGAGNGDRHQ***KKKWTLR NYLLCNL**NMEFHIRAMRLKLLVFFCLEKTNS *NKPQMYFSATHWP*VQFSCWLVLT*F*NRSQA CIFMSLFF*NPAYI*LFFL*LYYMKAA*E*SQTC FATKF*LECKLLSYTVLLMYVKFSYFVKTLRIN YHLI*IVLEN*RDFSF*IKYFRNSKHL

Frame 1

TSDLFGKEYSILLRASSRHYPTDQDFLMGKST* DLAISCPKLLLSQNKTLMQN*TRYFIFVCFNLP GCSLSCSALRILSHICCYYFCMHFSK*LT*AS*L KRNKRPS*RFCSGMLL*RGPKKRESDICLKKLR MTSS*RI*VANGFMKPRQKGTGTKSMAQISSEH L*ERRGPR*QLSRVKTEKMGQRKAG*IMSTKMLS FLQSWLAL*KSQKKMQHQQARVPVW*IQLPV*L ICPRKTQGNQMCLQRRGRIRLIAPSCQKVTHHN KLKMNSQKMEELVYFRLQKRMNCQSQKKSQLSQI LQSKS*RNQSRLCQAFQMGPKSRLQSPKPGR*S TNQLI*TKMITSLFLDKGQTP*KREGLREGSSS ATPVPVAQTQKPFVIITTLNPKAKLCHLA*PSMR EFLRRSIL*KTTLPQTPWSH*SM*DSLQ*RMSF HRVLG*SMVGK*ENLVF*NLTD*KMEWKMQGTQ KSFRVTLSLLNTESLRFFINQPQAHMYQKVKHIS Q*LLVLFQLMGCILIQKF*LQDHSLWRIHQPSM NPKINHQN*QGLNLYYPEALLMNCLIVLSLSHL RCQVAVLETVSKVQKKNPVLF*KLWKGVPLGKCL PKV*KTFHQIHQIKQK*IISQKN*CVVLKMMRN QIRSQLQMNAYQEFPQCLHNLIIHFLTLTNSKG *ASLFQHFSKMR*VAV**VFIVETLAIWKLKEIF SLQLNMWSH*RSCMFLWPSVRT*QQRM*KNSVQ THM*RPICYQTKAKWARRKHS**RKP*ILCITK YCGIKLKNKS*RHRN*TCPFGIGIHLSAIVS*GR WNLIWKHGTGITNRINN*DGTL*SGRQHQLPLK QKTEVK*N*LSSMSQSQSLVKSFLQLEKCTSG* RNALIYHC*GEVI*ILLLNVPSFQIQVGKVARRQ EL*GKPPTLSSTTLWCMMGSGLKI*WKPV*SLL SGTITN*PTNFWEVFVLALEQVKVMGLKWTGWT LLQRKLLSGRRW*TPPILGLKQHCLSECF*LPRF PNEPKFHWLLH*KLLNRWNLILKI*VGGQISSL SIYCT*GILHSM*KSICMCFFDYKAQGI*I*QN V*FVTLILNKIFEQARKIEFLLLLQRKSCPRALN MGYC*EAKCSCLPSCVSHHNSVPQLRGSGTLAG PL*VVGKSRRKILKVEQGMETDISDDKKKNGP* ETIYSVISNKIWNSILGQ*D*NYWCFSALRKQTV KTSLKCILVPPTGHRYNSVVGLF*LNSKIGLKP VFL*VYFFKTLHIYDCFSYNFTI*KQHKSSHKH VLQQSFN*NVSCSVILFFLCM*NFRIL*KPLE*I II*FKLY*KISVTSHFK*NILGILNI*

Frame 2

QATCLARNTASF*EPLLDTIPQTRTSSWERALR ILLSAALNFC*AKIRL*CRTEQDISFLCVLIFL VAVLVVQP*EF*ATFVAIIFACTFQND*LKLPD *RGTRGHHEGFAAGCCSEEGRRRESQTFA*KN*G *PAAEEYEWPMVL*SQGKKAQGQNPWRRYHQSI YEKEEAPDSS*AE*RQRKWGKGKLGE*CQQRCF PSSRAGWRCRRARRRCSTSKPEFQCGKSSFQCD* YVPGKHKETKCVSREEEESV**LQVARRSLITT N*K*TVKKWKNWFISDFKRG*IVRVKRKVNCRR YFNPKVREIKADFARPFKWVPNQGSNPQSQEDDL QIN*FKQR**PVFS*TKDRLPESERGSERDPQA QLQFQ*HRLRNPSL*SQL*TQKQNCVTWPNHP* ENF*EGAFFRRQLFPKLPGAIKACEILCSEG*AS TESWANPWSGSRRI*CFRI*QIEKWNGRCRGHR RVSE*P*AFSIQKAFAFSSINLKPICIKK*NTS ANDFWFFSN*WAAFSFRSFNCKTTVYGEFTNHQ* TQR*IIRINKA*ICITQKPC**TVSLC*A*AIS GARWQF*RPSARFRRRTQSCFENFGKECR*ENA FQKSRRHFIRFIKSSKSR*SARRISA*C*R**ET RSEASYK*MRTKNFHSAYTT**SIFSP*QTQKD EQVCSSISPR*GEWQCDECL*WRLWQSGS*RKY SVCN*ICGVTEGVACFCGPV*GLSSSGCKKTAFR PICKGLFATRQRQNGQEENTRSEENLESCV*RN TAV*N*KTNLKDTEIEPVHLASGYI*AQ*FPRG GGT*FGNMGLG*QTE*TIEMVPSEAEDSTSCP*S RKQR*NETSSPVCPRASPW*KASYNWRSAHLGE GMP*STTAKGKSSKFFC*MYHPSRYK*EKSPED KSCRENHQPYLQPHYGV*WVQA*RSDGSLCRAYC LGPLQINQPIFGRSSYWLWNR*KLWD*SGLDGL YFRGSCSLGEDGKLPQYLD*SNTASQNAFDCQD FQMSPNSTGSSTENY*TGGI*S*KSE*VDKYPHF LSIAPKEYYTACKSQSACASLITRPKGFKYNKM CNL*L*Y*IRYLNKLGKLNFCCCFKEKAAPEH* TWGIVKKQNVLVCHHVFHTTILCHS*EGLVPLQD LCRLWEKVAERYSKWSREWRQTSVMIKKKMDLK KLFTL*SLIKYGIPY*GNETETTGVFLP*ENKQ LKQASNVF*CHPLAIGTIQLLACFDLILK*VSSL YFYEFIFLKPCIYMIVFLITLLYESSIRVVTNM FCNKVLIRM*VAQLYCSSYVCKIFVFCKNP*NK LSFDLNCIRKLA*LLILNKIF*EF*TSK

Sequence NM_206928

CTAAAAGAAAGAATGGATGAACCCAATGCAGAACAGGTCTATAATCCCTCTCAGTTTGAGAATTTGAGAAAGTTTTGGGACTTAGAAGCTAATTCAAACA GTAAGGATAATGACAAGAATATTACCACCACAAGCCAAAAAAATTCTGCACCTTTTAATAGGCAGAAACACAAGGAATTCAGCGACATTAAATTATCAGG TAAAAATACCCATGAAGCAGAGGTGCTTCTAAGCCCAAAAAAAGTTATGGCAAGAGAGGAAATGGAGAAATTAAATTCAAAGGGCATACTCCAGGTGCTA CCAGATGAAATCACATTTCCTTTGAGTCCACTTAGAAAGTATACTTATCAGTTGCCAGGAAATGAGTCATCAAAGGAAAATGTGGAAAAGAATACGGAAG GGATTGTTACTCCAGTGTTTAAGGAAGAAAAGGATTACTCAGAACAAGAGATTCAAGAATCCATAATAAAAACCAATGTTTTGTCTAAAGACTGCAAAGA CACTTTTAATGACAGCTTGCAGAAACTGCTTTCAGAAACCTCAACACCAGCAATTCAACCCTCTGGTGGAAAAGTTCATGGAAAACAAGTGCTTGAACCA AGTGTTTCTGAAAATAGGACATGGCCTCAAAAAACAGATTTTGCTGATACTGAGGAAGAAGTCAAAGGACCTGAGAAGATCATTAATGAGCATGTTGACA AAACAGTAGTTCATCCAAAGGTTAAACGGAACTCTTTGACTGCTAGTCTAGACAAACTCCTGAAGGAAGCAACTGGAACTTCACCCTCTCCCTTGCAAGC CAAGTTGGCGCCTGTTATCACTGGAACCAACTCTAAGCTGGAAGAGGGGAGATTTTTTGGAAAAGGGATAGAACAGAGTCACAATACTTCAGCTGATAAG AGAGAAATACTAGCTCCTTTTCCAGTGAGAGATGAAACTTTTGGAAATACAGCTCTCCTCAAGAAAGCTGAAAGTGGTGAGTGCCAGCTAAGCACACAGA ATTTGATTCAGATGGCTGCAGAAGATTCTCATCCATTGGATCCAACTTCCCAGCTTTCCAGAAAGGGTTCTTTTGGGGATGTGGCCAGCCCTCCCCAAGA TATGCTTTTTCCCCAGGATGCTCATCTTGTTCCCCAGGCTAGGGTACACCCTTCTCAAACGGAAATTTCGGAGACTGTAGAGAAAGTCATTCTTCCACCC AGACCTGTATTGAATGATGTAAGTGCTGCATTACAGAAGCTGTGTGGAGAAGTATGGTTAAGTTATCCAGCTGGAAGGGAAGTAGGTCCTGGAGAAGTGA ACCCAGAATTTCCTGAAGCAGTACAGCCAGTATGTAGCCCCCTAAATCCTCCAGGAGTGATATCACCATGGGCTACGATGGACACCATAGTTCCAGACAG GAAGGATTTTTATTCCTCCAATGTAGTTCCTGATAAAACTCATGAAGTTGGATCTTATTTAGCTGCCCAAATGTCTCCATCAGACCAGACGCTTAGCTCA TTTGCTTCCATTGTTGCTCAATATGGCAAAGGCCTCCCTCAGGAAGTGGAAGAAATTGTGAGGGAAACAATTGTTCAACCCAAATCAGAGTTCCTCGAAT TCAGTGCTGGCTTAGAAAAACTACTGAAGGAAGAAACTGAAACCTTCCCCTCAAAATATGAAAGTGATACAGGGAATCTTTCTCCATCAAAGTTAATAGG TAGTACAGAGGAGCCCAGGCGAGCCACTTCTGAATGCCATCCTGAGGAATTAAAAGAAACAGTAGAAAAGGCCGAGGCTCCGTTAATAACTGAGAGTGCT TTTGATGCTGGTTTTGAGAAACTTCTTAAAGAAATAACTGAAGCTCCTCCTTATCAGCCCCAGGTGTCAGTGAGAGAAGAAACTCACGAGAAGGAGTCCT CACAGTCAGAGCAGACCAGGTTCTTGGGGACAGTGCCCCATTTTTACAGGGCAGCCTCACAGACCTCTGAAATGAAGGATAAAAGTAATGGTTTGGAATC TCAAGTCAACCAATGTGATAAAATGTTGGGAGGAGACGCACTTGTGACTGATTTATTGGTAGATTTTTGTGGTTCCAGAAGTGGAGTTGAGATCCCTAGA ACCCCACAACTTTATGTGGCTCATGAAATAGGGACCATTAAAACTGTAACCCCCCCAGAGGACAGGGACAGTGAAAGTGGGGTTGCAGGGGGACAAGGGA CTCTTCAGGAACCTGGCTTTGGAGAGGCTTCTGAAGCAATTAGTGTGTCCAGAAATAGGCAACCCATTCCTCTCCTGATGAACAAAGAAAACTCTACAAA AACAAGTAAAGTTGAATTGACTCTAGCATCGCCATATATGAAACAAGAGAAAGAGGAAGAAAAAGAAGGTTTCTCTGAGTCTGATTTTTCAGATGGAAAC ACCAGTTCTAATGCAGAGAGCTGGAGAAATCCTTCCAGTTCAGAAGAAGAACCCAGTCCTGTTTTGAAAACTTTGGAAAGGAGTGCCGCTAGGAAAATGC CTTCCAAAAGTCTAGAAGACATTTCATCAGATTCATCAAATCAAGCAAAAGTAGATAATCAGCCAGAAGAATTAGTGCGTAGTGCTGAAGATGTTTCCAC AGTGCCTACACAACCTGATAATCCATTTTCTCACCCTGACAAACTCAAAAGGATGAGCAAGTCTGTTCCAGCATTTCTCCAAGATGAGAGTGATGACAGA GAAACAGATACAGCATCAGAAAGCAGTTACCAGCTCAGCAGACACAAGAAGAGCCCGAGCTCTTTAACCAATCTTAGCAGCTCCTCTGGCATGACGTCCT TGTCTTCTGTGAGTGGCAGTGTGATGAGTGTTTATAGTGGAGACTTTGGCAATCTGGAAGTTAAAGGAAATATTCAGTTTGCAATTGAATATGTGGAGTC ACTGAAGGAGTTGCATGTTTTTGTGGCCCAGTGTAAGGACTTAGCAGCAGCGGATGTAAAAAAACAGCGTTCAGACCCATATGTAAAGGCCTATTTGCTA CCAGACAAAGGCAAAATGGGCAAGAAGAAAACACTCGTAGTGAAGAAAACCTTGAATCCTGTGTATAACGAAATACTGCGGTATAAAATTGAAAAACAAA TCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGA CTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTA GCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAA GGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCC TATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAAC CAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGG AGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGC TCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACT ACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAAT AAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAAT GTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCG CAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAAT AAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTAG TGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTTTTAA AACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAAT GTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAAACCCTTAGAATAAATTATCATTTGATTTAAATTGTATTAGA AAATTAGCGTGACTTCTCATTTTAAATAAAATATTTTAGGAATTCTAAACATCTAAA

refseq_SYTL2.F1 (forward primer)
refseq_SYTL2.R1 (reverse primer)
Single exon skipping

Sequence Tools

Translations

Frame 0

LKERMDEPNAEQVYNPSQFENLRKFWDLEANSN SKDNDKNITTTSQKNSAPFNRQKHKEFSDIKLSG KNTHEAEVLLSPKKVMAREEMEKLNSKGILQVL PDEITFPLSPLRKYTYQLPGNESSKENVEKNTE GIVTPVFKEEKDYSEQEIQESIIKTNVLSKDCKD TFNDSLQKLLSETSTPAIQPSGGKVHGKQVLEP SVSENRTWPQKTDFADTEEEVKGPEKIINEHVD KTVVHPKVKRNSLTASLDKLLKEATGTSPSPLQA KLAPVITGTNSKLEEGRFFGKGIEQSHNTSADK REILAPFPVRDETFGNTALLKKAESGECQLSTQ NLIQMAAEDSHPLDPTSQLSRKGSFGDVASPPQD MLFPQDAHLVPQARVHPSQTEISETVEKVILPP RPVLNDVSAALQKLCGEVWLSYPAGREVGPGEV NPEFPEAVQPVCSPLNPPGVISPWATMDTIVPDR KDFYSSNVVPDKTHEVGSYLAAQMSPSDQTLSS FASIVAQYGKGLPQEVEEIVRETIVQPKSEFLE FSAGLEKLLKEETETFPSKYESDTGNLSPSKLIG STEEPRRATSECHPEELKETVEKAEAPLITESA FDAGFEKLLKEITEAPPYQPQVSVREETHEKES SQSEQTRFLGTVPHFYRAASQTSEMKDKSNGLES QVNQCDKMLGGDALVTDLLVDFCGSRSGVEIPR TPQLYVAHEIGTIKTVTPPEDRDSESGVAGGQG TLQEPGFGEASEAISVSRNRQPIPLLMNKENSTK TSKVELTLASPYMKQEKEEEKEGFSESDFSDGN TSSNAESWRNPSSSEEEPSPVLKTLERSAARKM PSKSLEDISSDSSNQAKVDNQPEELVRSAEDVST VPTQPDNPFSHPDKLKRMSKSVPAFLQDESDDR ETDTASESSYQLSRHKKSPSSLTNLSSSSGMTS LSSVSGSVMSVYSGDFGNLEVKGNIQFAIEYVES LKELHVFVAQCKDLAAADVKKQRSDPYVKAYLL PDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQ ILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWD WDNKQNKQLRWYPLKRKTAPVALEAENRGEMKL ALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLL RGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNP IFNHTMVYDGFRPEDLMEACVELTVWDHYKLTN QFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALW EKMVNSPNTWIEATLPLRMLLIAKISK*AQIPLA PPLKTTKPVESDLENLSRWTNILTFYLLHLRNT TQHVKVNLHVLL*LQGPRDLNITKCVICDSNIK *DI*TS*EN*ISAAASKKKLPQSIKHGVLLRSKM FLFAIMCFTPQFCATVKRVWYPCRTFVGCGKKS QKDTQSGAGNGDRHQ***KKKWTLRNYLLCNL* *NMEFHIRAMRLKLLVFFCLEKTNS*NKPQMYFS ATHWP*VQFSCWLVLT*F*NRSQACIFMSLFF* NPAYI*LFFL*LYYMKAA*E*SQTCFATKF*LE CKLLSYTVLLMYVKFSYFVKTLRINYHLI*IVLE N*RDFSF*IKYFRNSKHL

Frame 1

*KKEWMNPMQNRSIIPLSLRI*ESFGT*KLIQT VRIMTRILPPQAKKILHLLIGRNTRNSATLNYQ VKIPMKQRCF*AQKKLWQERKWRN*IQRAYSRCY QMKSHFL*VHLESILISCQEMSHQRKMWKRIRK GLLLQCLRKKRITQNKRFKNP**KPMFCLKTAK TLLMTACRNCFQKPQHQQFNPLVEKFMENKCLNQ VFLKIGHGLKKQILLILRKKSKDLRRSLMSMLT KQ*FIQRLNGTL*LLV*TNS*RKQLELHPLPCK PSWRLLSLEPTLSWKRGDFLEKG*NRVTILQLIR EKY*LLFQ*EMKLLEIQLSSRKLKVVSAS*AHR I*FRWLQKILIHWIQLPSFPERVLLGMWPALPK ICFFPRMLILFPRLGYTLLKRKFRRL*RKSFFHP DLY*MM*VLHYRSCVEKYG*VIQLEGK*VLEK* TQNFLKQYSQYVAP*ILQE*YHHGLRWTP*FQT GRIFIPPM*FLIKLMKLDLI*LPKCLHQTRRLAH LLPLLLNMAKASLRKWKKL*GKQLFNPNQSSSN SVLA*KNY*RKKLKPSPQNMKVIQGIFLHQS** VVQRSPGEPLLNAILRN*KKQ*KRPRLR**LRVL LMLVLRNFLKK*LKLLLISPRCQ*EKKLTRRSP HSQSRPGSWGQCPIFTGQPHRPLK*RIKVMVWN LKSTNVIKCWEETHL*LIYW*IFVVPEVELRSLE PHNFMWLMK*GPLKL*PPQRTGTVKVGLQGDKG LFRNLALERLLKQLVCPEIGNPFLS**TKKTLQ KQVKLN*L*HRHI*NKRKRKKKKVSLSLIFQMET PVLMQRAGEILPVQKKNPVLF*KLWKGVPLGKC LPKV*KTFHQIHQIKQK*IISQKN*CVVLKMFP QCLHNLIIHFLTLTNSKG*ASLFQHFSKMRVMTE KQIQHQKAVTSSADTRRARAL*PILAAPLA*RP CLL*VAV**VFIVETLAIWKLKEIFSLQLNMWS H*RSCMFLWPSVRT*QQRM*KNSVQTHM*RPICY QTKAKWARRKHS**RKP*ILCITKYCGIKLKNK S*RHRN*TCPFGIGIHLSAIVS*GRWNLIWKHG TGITNRINN*DGTL*SGRQHQLPLKQKTEVK*N* LSSMSQSQSLVKSFLQLEKCTSG*RNALIYHC* GEVI*ILLLNVPSFQIQVGKVARRQEL*GKPPT LSSTTLWCMMGSGLKI*WKPV*SLLSGTITN*PT NFWEVFVLALEQVKVMGLKWTGWTLLQRKLLSG RRW*TPPILGLKQHCLSECF*LPRFPNEPKFHW LLH*KLLNRWNLILKI*VGGQISSLSIYCT*GIL HSM*KSICMCFFDYKAQGI*I*QNV*FVTLILN KIFEQARKIEFLLLLQRKSCPRALNMGYC*EAK CSCLPSCVSHHNSVPQLRGSGTLAGPL*VVGKSR RKILKVEQGMETDISDDKKKNGP*ETIYSVISN KIWNSILGQ*D*NYWCFSALRKQTVKTSLKCIL VPPTGHRYNSVVGLF*LNSKIGLKPVFL*VYFFK TLHIYDCFSYNFTI*KQHKSSHKHVLQQSFN*N VSCSVILFFLCM*NFRIL*KPLE*III*FKLY* KISVTSHFK*NILGILNI*

Frame 2

KRKNG*TQCRTGL*SLSV*EFEKVLGLRS*FKQ *G**QEYYHHKPKKFCTF**AETQGIQRH*IIR *KYP*SRGASKPKKSYGKRGNGEIKFKGHTPGA TR*NHISFEST*KVYLSVARK*VIKGKCGKEYGR DCYSSV*GRKGLLRTRDSRIHNKNQCFV*RLQR HF**QLAETAFRNLNTSNSTLWWKSSWKTSA*T KCF*K*DMASKNRFC*Y*GRSQRT*EDH**AC*Q NSSSSKG*TELFDC*SRQTPEGSNWNFTLSLAS QVGACYHWNQL*AGRGEIFWKRDRTESQYFS** ERNTSSFSSER*NFWKYSSPQES*KW*VPAKHTE FDSDGCRRFSSIGSNFPAFQKGFFWGCGQPSPR YAFSPGCSSCSPG*GTPFSNGNFGDCRESHSST QTCIE*CKCCITEAVWRSMVKLSSWKGSRSWRSE PRIS*SSTASM*PPKSSRSDITMGYDGHHSSRQ EGFLFLQCSS**NS*SWILFSCPNVSIRPDA*L ICFHCCSIWQRPPSGSGRNCEGNNCSTQIRVPRI QCWLRKTTEGRN*NLPLKI*K*YRESFSIKVNR *YRGAQASHF*MPS*GIKRNSRKGRGSVNN*EC F*CWF*ETS*RNN*SSSLSAPGVSERRNSREGVL TVRADQVLGDSAPFLQGSLTDL*NEG*K*WFGI SSQPM**NVGRRRTCD*FIGRFLWFQKWS*DP* NPTTLCGS*NRDH*NCNPPRGQGQ*KWGCRGTRD SSGTWLWRGF*SN*CVQK*ATHSSPDEQRKLYK NK*S*IDSSIAIYETRERGRKRRFL*V*FFRWK HQF*CRELEKSFQFRRRTQSCFENFGKECR*ENA FQKSRRHFIRFIKSSKSR*SARRISA*C*RCFH SAYTT**SIFSP*QTQKDEQVCSSISPR*E**Q RNRYSIRKQLPAQQTQEEPELFNQS*QLLWHDVL VFCEWQCDECL*WRLWQSGS*RKYSVCN*ICGV TEGVACFCGPV*GLSSSGCKKTAFRPICKGLFA TRQRQNGQEENTRSEENLESCV*RNTAV*N*KTN LKDTEIEPVHLASGYI*AQ*FPRGGGT*FGNMG LG*QTE*TIEMVPSEAEDSTSCP*SRKQR*NET SSPVCPRASPW*KASYNWRSAHLGEGMP*STTAK GKSSKFFC*MYHPSRYK*EKSPEDKSCRENHQP YLQPHYGV*WVQA*RSDGSLCRAYCLGPLQINQ PIFGRSSYWLWNR*KLWD*SGLDGLYFRGSCSLG EDGKLPQYLD*SNTASQNAFDCQDFQMSPNSTG SSTENY*TGGI*S*KSE*VDKYPHFLSIAPKEY YTACKSQSACASLITRPKGFKYNKMCNL*L*Y*I RYLNKLGKLNFCCCFKEKAAPEH*TWGIVKKQN VLVCHHVFHTTILCHS*EGLVPLQDLCRLWEKV AERYSKWSREWRQTSVMIKKKMDLKKLFTL*SLI KYGIPY*GNETETTGVFLP*ENKQLKQASNVF* CHPLAIGTIQLLACFDLILK*VSSLYFYEFIFL KPCIYMIVFLITLLYESSIRVVTNMFCNKVLIRM *VAQLYCSSYVCKIFVFCKNP*NKLSFDLNCIR KLA*LLILNKIF*EF*TSK

Sequence NM_032379

GTTTTTAAAATTAACTTTGTTTTGTATTTGGTTCAACTCCTTGCTAGTTCTCTCTCTATATAATTTATAAAAACTGCATGTTGCTAATCTCATGATCCTG TGCATGTGGACTACTCTGCCTTTAACTTTTTTACAAAAACATGTTTGTTCATAGATTAAATAAAAGTATGTTTTCAACTTAATGTCTAATGTTTTCTGAC AATTGTAAGAATAATTTTGAAATGGAAATGCTGCTGTTTAGTTTCCACAGTGCCTACACAACCTGATAATCCATTTTCTCACCCTGACAAACTCAAAAGG ATGAGCAAGTCTGTTCCAGCATTTCTCCAAGATGAGAGTGATGACAGAGAAACAGATACAGCATCAGAAAGCAGTTACCAGCTCAGCAGACACAAGAAGA GCCCGAGCTCTTTAACCAATCTTAGCAGCTCCTCTGGCATGACGTCCTTGTCTTCTGTGAGTGGCAGTGTGATGAGTGTTTATAGTGGAGACTTTGGCAA TCTGGAAGTTAAAGGAAATATTCAGTTTGCAATTGAATATGTGGAGTCACTGAAGGAGTTGCATGTTTTTGTGGCCCAGTGTAAGGACTTAGCAGCAGCG GATGTAAAAAAACAGCGTTCAGACCCATATGTAAAGGCCTATTTGCTACCAGACAAAGGCAAAATGGGCAAGAAGAAAACACTCGTAGTGAAGAAAACCT TGAATCCTGTGTATAACGAAATACTGCGGTATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAA GCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAG ACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTG GAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAG TAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATG GAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGA CTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAG AATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGT AGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAA GGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAA AAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAG AGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGAT AAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTT CTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAA TTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAG CATAAGAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTT TGTAAAAACCCTTAGAATAAATTATCATTTGATTTAAATTGTATTAGAAAATTAGCGTGACTTCTCATTTTAAATAAAATATTTTAGGAATTCTAAACAT CTAAA

refseq_SYTL2.F1 (forward primer)
refseq_SYTL2.R1 (reverse primer)
Single exon skipping

Sequence Tools

Translations

Frame 0

VFKINFVLYLVQLLASSLSI*FIKTACC*SHDP VHVDYSAFNFFTKTCLFID*IKVCFQLNV*CFLT IVRIILKWKCCCLVSTVPTQPDNPFSHPDKLKR MSKSVPAFLQDESDDRETDTASESSYQLSRHKK SPSSLTNLSSSSGMTSLSSVSGSVMSVYSGDFGN LEVKGNIQFAIEYVESLKELHVFVAQCKDLAAA DVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKT LNPVYNEILRYKIEKQILKTQKLNLSIWHRDTFK RNSFLGEVELDLETWDWDNKQNKQLRWYPLKRK TAPVALEAENRGEMKLALQYVPEPVPGKKLPTT GEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTS RKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLM EACVELTVWDHYKLTNQFLGGLRIGFGTGKSYG TEVDWMDSTSEEVALWEKMVNSPNTWIEATLPLR MLLIAKISK*AQIPLAPPLKTTKPVESDLENLS RWTNILTFYLLHLRNTTQHVKVNLHVLL*LQGP RDLNITKCVICDSNIK*DI*TS*EN*ISAAASKK KLPQSIKHGVLLRSKMFLFAIMCFTPQFCATVK RVWYPCRTFVGCGKKSQKDTQSGAGNGDRHQ** *KKKWTLRNYLLCNL**NMEFHIRAMRLKLLVFF CLEKTNS*NKPQMYFSATHWP*VQFSCWLVLT* F*NRSQACIFMSLFF*NPAYI*LFFL*LYYMKA A*E*SQTCFATKF*LECKLLSYTVLLMYVKFSYF VKTLRINYHLI*IVLEN*RDFSF*IKYFRNSKH L

Frame 1

FLKLTLFCIWFNSLLVLSLYNL*KLHVANLMIL CMWTTLPLTFLQKHVCS*IK*KYVFNLMSNVF* QL*E*F*NGNAAV*FPQCLHNLIIHFLTLTNSKG *ASLFQHFSKMRVMTEKQIQHQKAVTSSADTRR ARAL*PILAAPLA*RPCLL*VAV**VFIVETLA IWKLKEIFSLQLNMWSH*RSCMFLWPSVRT*QQR M*KNSVQTHM*RPICYQTKAKWARRKHS**RKP *ILCITKYCGIKLKNKS*RHRN*TCPFGIGIHL SAIVS*GRWNLIWKHGTGITNRINN*DGTL*SGR QHQLPLKQKTEVK*N*LSSMSQSQSLVKSFLQL EKCTSG*RNALIYHC*GEVI*ILLLNVPSFQIQ VGKVARRQEL*GKPPTLSSTTLWCMMGSGLKI*W KPV*SLLSGTITN*PTNFWEVFVLALEQVKVMG LKWTGWTLLQRKLLSGRRW*TPPILGLKQHCLS ECF*LPRFPNEPKFHWLLH*KLLNRWNLILKI*V GGQISSLSIYCT*GILHSM*KSICMCFFDYKAQ GI*I*QNV*FVTLILNKIFEQARKIEFLLLLQR KSCPRALNMGYC*EAKCSCLPSCVSHHNSVPQLR GSGTLAGPL*VVGKSRRKILKVEQGMETDISDD KKKNGP*ETIYSVISNKIWNSILGQ*D*NYWCF SALRKQTVKTSLKCILVPPTGHRYNSVVGLF*LN SKIGLKPVFL*VYFFKTLHIYDCFSYNFTI*KQ HKSSHKHVLQQSFN*NVSCSVILFFLCM*NFRI L*KPLE*III*FKLY*KISVTSHFK*NILGILNI *

Frame 2

F*N*LCFVFGSTPC*FSLYIIYKNCMLLIS*SC ACGLLCL*LFYKNMFVHRLNKSMFST*CLMFSD NCKNNFEMEMLLFSFHSAYTT**SIFSP*QTQK DEQVCSSISPR*E**QRNRYSIRKQLPAQQTQEE PELFNQS*QLLWHDVLVFCEWQCDECL*WRLWQ SGS*RKYSVCN*ICGVTEGVACFCGPV*GLSSS GCKKTAFRPICKGLFATRQRQNGQEENTRSEENL ESCV*RNTAV*N*KTNLKDTEIEPVHLASGYI* AQ*FPRGGGT*FGNMGLG*QTE*TIEMVPSEAE DSTSCP*SRKQR*NETSSPVCPRASPW*KASYNW RSAHLGEGMP*STTAKGKSSKFFC*MYHPSRYK *EKSPEDKSCRENHQPYLQPHYGV*WVQA*RSD GSLCRAYCLGPLQINQPIFGRSSYWLWNR*KLWD *SGLDGLYFRGSCSLGEDGKLPQYLD*SNTASQ NAFDCQDFQMSPNSTGSSTENY*TGGI*S*KSE *VDKYPHFLSIAPKEYYTACKSQSACASLITRPK GFKYNKMCNL*L*Y*IRYLNKLGKLNFCCCFKE KAAPEH*TWGIVKKQNVLVCHHVFHTTILCHS* EGLVPLQDLCRLWEKVAERYSKWSREWRQTSVMI KKKMDLKKLFTL*SLIKYGIPY*GNETETTGVF LP*ENKQLKQASNVF*CHPLAIGTIQLLACFDL ILK*VSSLYFYEFIFLKPCIYMIVFLITLLYESS IRVVTNMFCNKVLIRM*VAQLYCSSYVCKIFVF CKNP*NKLSFDLNCIRKLA*LLILNKIF*EF*T SK

Sequence NM_206929

ACAGAAGAATAGAGAGGCTGTTGCAGCCCCGTGCTTTCTCCTGCTGCTGGCCGATTGCTTGCTCTGAACTAACCCTCTAACCCTTGGGAGTCTGTGTGCA GCAGTGATGTGAGCTGCATCCGGGCTGAAATGGGAGCTCCCGCTATGGCACTGGCTCAAGGAGCTAATCTAAAGAGAAAATCAAGCAAAAGTAGATAATC AGCCAGAAGAATTAGTGCGTAGTGCTGAAGATGATGAGAAACCAGATCAGAAGCCAGTTACAAATGAATGCGTACCAAGAATTTCCACAGTGCCTACACA ACCTGATAATCCATTTTCTCACCCTGACAAACTCAAAAGGATGAGCAAGTCTGTTCCAGCATTTCTCCAAGATGAGAGTGATGACAGAGAAACAGATACA GCATCAGAAAGCAGTTACCAGCTCAGCAGACACAAGAAGAGCCCGAGCTCTTTAACCAATCTTAGCAGCTCCTCTGGCATGACGTCCTTGTCTTCTGTGA GTGGCAGTGTGATGAGTGTTTATAGTGGAGACTTTGGCAATCTGGAAGTTAAAGGAAATATTCAGTTTGCAATTGAATATGTGGAGTCACTGAAGGAGTT GCATGTTTTTGTGGCCCAGTGTAAGGACTTAGCAGCAGCGGATGTAAAAAAACAGCGTTCAGACCCATATGTAAAGGCCTATTTGCTACCAGACAAAGGC AAAATGGGCAAGAAGAAAACACTCGTAGTGAAGAAAACCTTGAATCCTGTGTATAACGAAATACTGCGGTATAAAATTGAAAAACAAATCTTAAAGACAC AGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAA ACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTAT GTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATC TAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCA CACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGA GGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAA ACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAA AACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTA AAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAA CAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGC CATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACT CAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGGAAT TCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCACCCACTG GCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTTTTAAAACCCTGCATAT ATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCA GTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAAACCCTTAGAATAAATTATCATTTGATTTAAATTGTATTAGAAAATTAGCGTGA CTTCTCATTTTAAATAAAATATTTTAGGAATTCTAAACATCTAAA

refseq_SYTL2.F1 (forward primer)
refseq_SYTL2.R1 (reverse primer)
Single exon skipping

Sequence Tools

Translations

Frame 0

TEE*RGCCSPVLSPAAGRLLALN*PSNPWESVC SSDVSCIRAEMGAPAMALAQGANLKRKSSKSR*S ARRISA*C*R**ETRSEASYK*MRTKNFHSAYT T**SIFSP*QTQKDEQVCSSISPR*E**QRNRY SIRKQLPAQQTQEEPELFNQS*QLLWHDVLVFCE WQCDECL*WRLWQSGS*RKYSVCN*ICGVTEGV ACFCGPV*GLSSSGCKKTAFRPICKGLFATRQR QNGQEENTRSEENLESCV*RNTAV*N*KTNLKDT EIEPVHLASGYI*AQ*FPRGGGT*FGNMGLG*Q TE*TIEMVPSEAEDSTSCP*SRKQR*NETSSPV CPRASPW*KASYNWRSAHLGEGMP*STTAKGKSS KFFC*MYHPSRYK*EKSPEDKSCRENHQPYLQP HYGV*WVQA*RSDGSLCRAYCLGPLQINQPIFG RSSYWLWNR*KLWD*SGLDGLYFRGSCSLGEDGK LPQYLD*SNTASQNAFDCQDFQMSPNSTGSSTE NY*TGGI*S*KSE*VDKYPHFLSIAPKEYYTAC KSQSACASLITRPKGFKYNKMCNL*L*Y*IRYLN KLGKLNFCCCFKEKAAPEH*TWGIVKKQNVLVC HHVFHTTILCHS*EGLVPLQDLCRLWEKVAERY SKWSREWRQTSVMIKKKMDLKKLFTL*SLIKYGI PY*GNETETTGVFLP*ENKQLKQASNVF*CHPL AIGTIQLLACFDLILK*VSSLYFYEFIFLKPCI YMIVFLITLLYESSIRVVTNMFCNKVLIRM*VAQ LYCSSYVCKIFVFCKNP*NKLSFDLNCIRKLA* LLILNKIF*EF*TSK

Frame 1

QKNREAVAAPCFLLLLADCLL*TNPLTLGSLCA AVM*AASGLKWELPLWHWLKELI*RENQAKVDN QPEELVRSAEDDEKPDQKPVTNECVPRISTVPTQ PDNPFSHPDKLKRMSKSVPAFLQDESDDRETDT ASESSYQLSRHKKSPSSLTNLSSSSGMTSLSSV SGSVMSVYSGDFGNLEVKGNIQFAIEYVESLKEL HVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKG KMGKKKTLVVKKTLNPVYNEILRYKIEKQILKT QKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNK QNKQLRWYPLKRKTAPVALEAENRGEMKLALQY VPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSH LNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNH TMVYDGFRPEDLMEACVELTVWDHYKLTNQFLG GLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMV NSPNTWIEATLPLRMLLIAKISK*AQIPLAPPLK TTKPVESDLENLSRWTNILTFYLLHLRNTTQHV KVNLHVLL*LQGPRDLNITKCVICDSNIK*DI* TS*EN*ISAAASKKKLPQSIKHGVLLRSKMFLFA IMCFTPQFCATVKRVWYPCRTFVGCGKKSQKDT QSGAGNGDRHQ***KKKWTLRNYLLCNL**NME FHIRAMRLKLLVFFCLEKTNS*NKPQMYFSATHW P*VQFSCWLVLT*F*NRSQACIFMSLFF*NPAY I*LFFL*LYYMKAA*E*SQTCFATKF*LECKLL SYTVLLMYVKFSYFVKTLRINYHLI*IVLEN*RD FSF*IKYFRNSKHL

Frame 2

RRIERLLQPRAFSCCWPIACSELTL*PLGVCVQ Q*CELHPG*NGSSRYGTGSRS*SKEKIKQK*II SQKN*CVVLKMMRNQIRSQLQMNAYQEFPQCLH NLIIHFLTLTNSKG*ASLFQHFSKMRVMTEKQIQ HQKAVTSSADTRRARAL*PILAAPLA*RPCLL* VAV**VFIVETLAIWKLKEIFSLQLNMWSH*RS CMFLWPSVRT*QQRM*KNSVQTHM*RPICYQTKA KWARRKHS**RKP*ILCITKYCGIKLKNKS*RH RN*TCPFGIGIHLSAIVS*GRWNLIWKHGTGIT NRINN*DGTL*SGRQHQLPLKQKTEVK*N*LSSM SQSQSLVKSFLQLEKCTSG*RNALIYHC*GEVI *ILLLNVPSFQIQVGKVARRQEL*GKPPTLSST TLWCMMGSGLKI*WKPV*SLLSGTITN*PTNFWE VFVLALEQVKVMGLKWTGWTLLQRKLLSGRRW* TPPILGLKQHCLSECF*LPRFPNEPKFHWLLH* KLLNRWNLILKI*VGGQISSLSIYCT*GILHSM* KSICMCFFDYKAQGI*I*QNV*FVTLILNKIFE QARKIEFLLLLQRKSCPRALNMGYC*EAKCSCL PSCVSHHNSVPQLRGSGTLAGPL*VVGKSRRKIL KVEQGMETDISDDKKKNGP*ETIYSVISNKIWN SILGQ*D*NYWCFSALRKQTVKTSLKCILVPPT GHRYNSVVGLF*LNSKIGLKPVFL*VYFFKTLHI YDCFSYNFTI*KQHKSSHKHVLQQSFN*NVSCS VILFFLCM*NFRIL*KPLE*III*FKLY*KISV TSHFK*NILGILNI*

Sequence NM_206927

CTAAAAGAAAGAATGGATGAACCCAATGCAGAACAGGTCTATAATCCCTCTCAGTTTGAGAATTTGAGAAAGTTTTGGGACTTAGAAGCTAATTCAAACA GTAAGGATAATGACAAGAATATTACCACCACAAGCCAAAAAAATTCTGCACCTTTTAATAGGCAGAAACACAAGGAATTCAGCGACATTAAATTATCAGG TAAAAATACCCATGAAGCAGAGGTGCTTCTAAGCCCAAAAAAAGTTATGGCAAGAGAGGAAATGGAGAAATTAAATTCAAAGGGCATACTCCAGGTGCTA CCAGATGAAATCACATTTCCTTTGAGTCCACTTAGAAAGTATACTTATCAGTTGCCAGGAAATGAGTCATCAAAGGAAAATGTGGAAAAGAATACGGAAG GGATTGTTACTCCAGTGTTTAAGGAAGAAAAGGATTACTCAGAACAAGAGATTCAAGAATCCATAATAAAAACCAATGTTTTGTCTAAAGACTGCAAAGA CACTTTTAATGACAGCTTGCAGAAACTGCTTTCAGAAACCTCAACACCAGCAATTCAACCCTCTGGTGGAAAAGTTCATGGAAAACAAGTGCTTGAACCA AGTGTTTCTGAAAATAGGACATGGCCTCAAAAAACAGATTTTGCTGATACTGAGGAAGAAGTCAAAGGACCTGAGAAGATCATTAATGAGCATGTTGACA AAACAGTAGTTCATCCAAAGGTTAAACGGAACTCTTTGACTGCTAGTCTAGACAAACTCCTGAAGGAAGCAACTGGAACTTCACCCTCTCCCTTGCAAGC CAAGTTGGCGCCTGTTATCACTGGAACCAACTCTAAGCTGGAAGAGGGGAGATTTTTTGGAAAAGGGATAGAACAGAGTCACAATACTTCAGCTGATAAG AGAGAAATACTAGCTCCTTTTCCAGTGAGAGATGAAACTTTTGGAAATACAGCTCTCCTCAAGAAAGCTGAAAGTGGTGAGTGCCAGCTAAGCACACAGA ATTTGATTCAGATGGCTGCAGAAGATTCTCATCCATTGGATCCAACTTCCCAGCTTTCCAGAAAGGGTTCTTTTGGGGATGTGGCCAGCCCTCCCCAAGA TATGCTTTTTCCCCAGGATGCTCATCTTGTTCCCCAGGCTAGGGTACACCCTTCTCAAACGGAAATTTCGGAGACTGTAGAGAAAGTCATTCTTCCACCC AGACCTGTATTGAATGATGTAAGTGCTGCATTACAGAAGCTGTGTGGAGAAGTATGGTTAAGTTATCCAGCTGGAAGGGAAGTAGGTCCTGGAGAAGTGA ACCCAGAATTTCCTGAAGCAGTACAGCCAGTATGTAGCCCCCTAAATCCTCCAGGAGTGATATCACCATGGGCTACGATGGACACCATAGTTCCAGACAG GAAGGATTTTTATTCCTCCAATGTAGTTCCTGATAAAACTCATGAAGTTGGATCTTATTTAGCTGCCCAAATGTCTCCATCAGACCAGACGCTTAGCTCA TTTGCTTCCATTGTTGCTCAATATGGCAAAGGCCTCCCTCAGGAAGTGGAAGAAATTGTGAGGGAAACAATTGTTCAACCCAAATCAGAGTTCCTCGAAT TCAGTGCTGGCTTAGAAAAACTACTGAAGGAAGAAACTGAAACCTTCCCCTCAAAATATGAAAGTGATACAGGGAATCTTTCTCCATCAAAGTTAATAGG TAGTACAGAGGAGCCCAGGCGAGCCACTTCTGAATGCCATCCTGAGGAATTAAAAGAAACAGTAGAAAAGGCCGAGGCTCCGTTAATAACTGAGAGTGCT TTTGATGCTGGTTTTGAGAAACTTCTTAAAGAAATAACTGAAGCTCCTCCTTATCAGCCCCAGGTGTCAGTGAGAGAAGAAACTCACGAGAAGGAGTCCT CACAGTCAGAGCAGACCAGGTTCTTGGGGACAGTGCCCCATTTTTACAGGGCAGCCTCACAGACCTCTGAAATGAAGGATAAAAGTAATGGTTTGGAATC TCAAGTCAACCAATGTGATAAAATGTTGGGAGGAGACGCACTTGTGACTGATTTATTGGTAGATTTTTGTGGTTCCAGAAGTGGAGTTGAGATCCCTAGA ACCCCACAACTTTATGTGGCTCATGAAATAGGGACCATTAAAACTGTAACCCCCCCAGAGGACAGGGACAGTGAAAGTGGGGTTGCAGGGGGACAAGGGA CTCTTCAGGAACCTGGCTTTGGAGAGGCTTCTGAAGCAATTAGTGTGTCCAGAAATAGGCAACCCATTCCTCTCCTGATGAACAAAGAAAACTCTACAAA AACAAGTAAAGTTGAATTGACTCTAGCATCGCCATATATGAAACAAGAGAAAGAGGAAGAAAAAGAAGGTTTCTCTGAGTCTGATTTTTCAGATGGAAAC ACCAGTTCTAATGCAGAGAGCTGGAGAAATCCTTCCAGTTCAGAAGAAGAACCCAGTCCTGTTTTGAAAACTTTGGAAAGGAGTGCCGCTAGGAAAATGC CTTCCAAAAGTCTAGAAGACATTTCATCAGATTCATCAAATCAAGCAAAAGTAGATAATCAGCCAGAAGAATTAGTGCGTAGTGCTGAAGATGATGAGAA ACCAGATCAGAAGCCAGTTACAAATGAATGCGTACCAAGAATTTCCACAGTGCCTACACAACCTGATAATCCATTTTCTCACCCTGACAAACTCAAAAGG ATGAGCAAGTCTGTTCCAGCATTTCTCCAAGATGAGAGTGATGACAGAGAAACAGATACAGCATCAGAAAGCAGTTACCAGCTCAGCAGACACAAGAAGA GCCCGAGCTCTTTAACCAATCTTAGCAGCTCCTCTGGCATGACGTCCTTGTCTTCTGTGAGTGGCAGTGTGATGAGTGTTTATAGTGGAGACTTTGGCAA TCTGGAAGTTAAAGGAAATATTCAGTTTGCAATTGAATATGTGGAGTCACTGAAGGAGTTGCATGTTTTTGTGGCCCAGTGTAAGGACTTAGCAGCAGCG GATGTAAAAAAACAGCGTTCAGACCCATATGTAAAGGCCTATTTGCTACCAGACAAAGGCAAAATGGGCAAGAAGAAAACACTCGTAGTGAAGAAAACCT TGAATCCTGTGTATAACGAAATACTGCGGTATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAA GCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAG ACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTG GAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAG TAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATG GAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGA CTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAG AATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGT AGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAA GGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAA AAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAG AGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGAT AAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTT CTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAA TTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAG CATAAGAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTT TGTAAAAACCCTTAGAATAAATTATCATTTGATTTAAATTGTATTAGAAAATTAGCGTGACTTCTCATTTTAAATAAAATATTTTAGGAATTCTAAACAT CTAAA

refseq_SYTL2.F1 (forward primer)
refseq_SYTL2.R1 (reverse primer)
Single exon skipping

Sequence Tools

Translations

Frame 0

LKERMDEPNAEQVYNPSQFENLRKFWDLEANSN SKDNDKNITTTSQKNSAPFNRQKHKEFSDIKLSG KNTHEAEVLLSPKKVMAREEMEKLNSKGILQVL PDEITFPLSPLRKYTYQLPGNESSKENVEKNTE GIVTPVFKEEKDYSEQEIQESIIKTNVLSKDCKD TFNDSLQKLLSETSTPAIQPSGGKVHGKQVLEP SVSENRTWPQKTDFADTEEEVKGPEKIINEHVD KTVVHPKVKRNSLTASLDKLLKEATGTSPSPLQA KLAPVITGTNSKLEEGRFFGKGIEQSHNTSADK REILAPFPVRDETFGNTALLKKAESGECQLSTQ NLIQMAAEDSHPLDPTSQLSRKGSFGDVASPPQD MLFPQDAHLVPQARVHPSQTEISETVEKVILPP RPVLNDVSAALQKLCGEVWLSYPAGREVGPGEV NPEFPEAVQPVCSPLNPPGVISPWATMDTIVPDR KDFYSSNVVPDKTHEVGSYLAAQMSPSDQTLSS FASIVAQYGKGLPQEVEEIVRETIVQPKSEFLE FSAGLEKLLKEETETFPSKYESDTGNLSPSKLIG STEEPRRATSECHPEELKETVEKAEAPLITESA FDAGFEKLLKEITEAPPYQPQVSVREETHEKES SQSEQTRFLGTVPHFYRAASQTSEMKDKSNGLES QVNQCDKMLGGDALVTDLLVDFCGSRSGVEIPR TPQLYVAHEIGTIKTVTPPEDRDSESGVAGGQG TLQEPGFGEASEAISVSRNRQPIPLLMNKENSTK TSKVELTLASPYMKQEKEEEKEGFSESDFSDGN TSSNAESWRNPSSSEEEPSPVLKTLERSAARKM PSKSLEDISSDSSNQAKVDNQPEELVRSAEDDEK PDQKPVTNECVPRISTVPTQPDNPFSHPDKLKR MSKSVPAFLQDESDDRETDTASESSYQLSRHKK SPSSLTNLSSSSGMTSLSSVSGSVMSVYSGDFGN LEVKGNIQFAIEYVESLKELHVFVAQCKDLAAA DVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKT LNPVYNEILRYKIEKQILKTQKLNLSIWHRDTFK RNSFLGEVELDLETWDWDNKQNKQLRWYPLKRK TAPVALEAENRGEMKLALQYVPEPVPGKKLPTT GEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTS RKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLM EACVELTVWDHYKLTNQFLGGLRIGFGTGKSYG TEVDWMDSTSEEVALWEKMVNSPNTWIEATLPLR MLLIAKISK*AQIPLAPPLKTTKPVESDLENLS RWTNILTFYLLHLRNTTQHVKVNLHVLL*LQGP RDLNITKCVICDSNIK*DI*TS*EN*ISAAASKK KLPQSIKHGVLLRSKMFLFAIMCFTPQFCATVK RVWYPCRTFVGCGKKSQKDTQSGAGNGDRHQ** *KKKWTLRNYLLCNL**NMEFHIRAMRLKLLVFF CLEKTNS*NKPQMYFSATHWP*VQFSCWLVLT* F*NRSQACIFMSLFF*NPAYI*LFFL*LYYMKA A*E*SQTCFATKF*LECKLLSYTVLLMYVKFSYF VKTLRINYHLI*IVLEN*RDFSF*IKYFRNSKH L

Frame 1

*KKEWMNPMQNRSIIPLSLRI*ESFGT*KLIQT VRIMTRILPPQAKKILHLLIGRNTRNSATLNYQ VKIPMKQRCF*AQKKLWQERKWRN*IQRAYSRCY QMKSHFL*VHLESILISCQEMSHQRKMWKRIRK GLLLQCLRKKRITQNKRFKNP**KPMFCLKTAK TLLMTACRNCFQKPQHQQFNPLVEKFMENKCLNQ VFLKIGHGLKKQILLILRKKSKDLRRSLMSMLT KQ*FIQRLNGTL*LLV*TNS*RKQLELHPLPCK PSWRLLSLEPTLSWKRGDFLEKG*NRVTILQLIR EKY*LLFQ*EMKLLEIQLSSRKLKVVSAS*AHR I*FRWLQKILIHWIQLPSFPERVLLGMWPALPK ICFFPRMLILFPRLGYTLLKRKFRRL*RKSFFHP DLY*MM*VLHYRSCVEKYG*VIQLEGK*VLEK* TQNFLKQYSQYVAP*ILQE*YHHGLRWTP*FQT GRIFIPPM*FLIKLMKLDLI*LPKCLHQTRRLAH LLPLLLNMAKASLRKWKKL*GKQLFNPNQSSSN SVLA*KNY*RKKLKPSPQNMKVIQGIFLHQS** VVQRSPGEPLLNAILRN*KKQ*KRPRLR**LRVL LMLVLRNFLKK*LKLLLISPRCQ*EKKLTRRSP HSQSRPGSWGQCPIFTGQPHRPLK*RIKVMVWN LKSTNVIKCWEETHL*LIYW*IFVVPEVELRSLE PHNFMWLMK*GPLKL*PPQRTGTVKVGLQGDKG LFRNLALERLLKQLVCPEIGNPFLS**TKKTLQ KQVKLN*L*HRHI*NKRKRKKKKVSLSLIFQMET PVLMQRAGEILPVQKKNPVLF*KLWKGVPLGKC LPKV*KTFHQIHQIKQK*IISQKN*CVVLKMMR NQIRSQLQMNAYQEFPQCLHNLIIHFLTLTNSKG *ASLFQHFSKMRVMTEKQIQHQKAVTSSADTRR ARAL*PILAAPLA*RPCLL*VAV**VFIVETLA IWKLKEIFSLQLNMWSH*RSCMFLWPSVRT*QQR M*KNSVQTHM*RPICYQTKAKWARRKHS**RKP *ILCITKYCGIKLKNKS*RHRN*TCPFGIGIHL SAIVS*GRWNLIWKHGTGITNRINN*DGTL*SGR QHQLPLKQKTEVK*N*LSSMSQSQSLVKSFLQL EKCTSG*RNALIYHC*GEVI*ILLLNVPSFQIQ VGKVARRQEL*GKPPTLSSTTLWCMMGSGLKI*W KPV*SLLSGTITN*PTNFWEVFVLALEQVKVMG LKWTGWTLLQRKLLSGRRW*TPPILGLKQHCLS ECF*LPRFPNEPKFHWLLH*KLLNRWNLILKI*V GGQISSLSIYCT*GILHSM*KSICMCFFDYKAQ GI*I*QNV*FVTLILNKIFEQARKIEFLLLLQR KSCPRALNMGYC*EAKCSCLPSCVSHHNSVPQLR GSGTLAGPL*VVGKSRRKILKVEQGMETDISDD KKKNGP*ETIYSVISNKIWNSILGQ*D*NYWCF SALRKQTVKTSLKCILVPPTGHRYNSVVGLF*LN SKIGLKPVFL*VYFFKTLHIYDCFSYNFTI*KQ HKSSHKHVLQQSFN*NVSCSVILFFLCM*NFRI L*KPLE*III*FKLY*KISVTSHFK*NILGILNI *

Frame 2

KRKNG*TQCRTGL*SLSV*EFEKVLGLRS*FKQ *G**QEYYHHKPKKFCTF**AETQGIQRH*IIR *KYP*SRGASKPKKSYGKRGNGEIKFKGHTPGA TR*NHISFEST*KVYLSVARK*VIKGKCGKEYGR DCYSSV*GRKGLLRTRDSRIHNKNQCFV*RLQR HF**QLAETAFRNLNTSNSTLWWKSSWKTSA*T KCF*K*DMASKNRFC*Y*GRSQRT*EDH**AC*Q NSSSSKG*TELFDC*SRQTPEGSNWNFTLSLAS QVGACYHWNQL*AGRGEIFWKRDRTESQYFS** ERNTSSFSSER*NFWKYSSPQES*KW*VPAKHTE FDSDGCRRFSSIGSNFPAFQKGFFWGCGQPSPR YAFSPGCSSCSPG*GTPFSNGNFGDCRESHSST QTCIE*CKCCITEAVWRSMVKLSSWKGSRSWRSE PRIS*SSTASM*PPKSSRSDITMGYDGHHSSRQ EGFLFLQCSS**NS*SWILFSCPNVSIRPDA*L ICFHCCSIWQRPPSGSGRNCEGNNCSTQIRVPRI QCWLRKTTEGRN*NLPLKI*K*YRESFSIKVNR *YRGAQASHF*MPS*GIKRNSRKGRGSVNN*EC F*CWF*ETS*RNN*SSSLSAPGVSERRNSREGVL TVRADQVLGDSAPFLQGSLTDL*NEG*K*WFGI SSQPM**NVGRRRTCD*FIGRFLWFQKWS*DP* NPTTLCGS*NRDH*NCNPPRGQGQ*KWGCRGTRD SSGTWLWRGF*SN*CVQK*ATHSSPDEQRKLYK NK*S*IDSSIAIYETRERGRKRRFL*V*FFRWK HQF*CRELEKSFQFRRRTQSCFENFGKECR*ENA FQKSRRHFIRFIKSSKSR*SARRISA*C*R**E TRSEASYK*MRTKNFHSAYTT**SIFSP*QTQK DEQVCSSISPR*E**QRNRYSIRKQLPAQQTQEE PELFNQS*QLLWHDVLVFCEWQCDECL*WRLWQ SGS*RKYSVCN*ICGVTEGVACFCGPV*GLSSS GCKKTAFRPICKGLFATRQRQNGQEENTRSEENL ESCV*RNTAV*N*KTNLKDTEIEPVHLASGYI* AQ*FPRGGGT*FGNMGLG*QTE*TIEMVPSEAE DSTSCP*SRKQR*NETSSPVCPRASPW*KASYNW RSAHLGEGMP*STTAKGKSSKFFC*MYHPSRYK *EKSPEDKSCRENHQPYLQPHYGV*WVQA*RSD GSLCRAYCLGPLQINQPIFGRSSYWLWNR*KLWD *SGLDGLYFRGSCSLGEDGKLPQYLD*SNTASQ NAFDCQDFQMSPNSTGSSTENY*TGGI*S*KSE *VDKYPHFLSIAPKEYYTACKSQSACASLITRPK GFKYNKMCNL*L*Y*IRYLNKLGKLNFCCCFKE KAAPEH*TWGIVKKQNVLVCHHVFHTTILCHS* EGLVPLQDLCRLWEKVAERYSKWSREWRQTSVMI KKKMDLKKLFTL*SLIKYGIPY*GNETETTGVF LP*ENKQLKQASNVF*CHPLAIGTIQLLACFDL ILK*VSSLYFYEFIFLKPCIYMIVFLITLLYESS IRVVTNMFCNKVLIRM*VAQLYCSSYVCKIFVF CKNP*NKLSFDLNCIRKLA*LLILNKIF*EF*T SK