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Sequences

Sequence NM_032943

AACAAGCGACCTGTTTGGCAAGGAATACAGCATCCTTCTGAGAGCCTCTTCTCGACACTATCCCACAGACCAGGACTTCCTCATGGGAAAGAGCACTTAG
GATCTTGCTATCAGCTGCCCTAAACTTTTGCTGAGCCAAAATAAGACTTTGATGCAGAACTGAACAAGATATTTCATTTTTGTGTGTTTTAATCTTCCTG
GTTGCAGTCTTAGTTGTTCAGCCCTGAGAATTTTGAGCCACATTTGTTGCTATTATTTTTGCATGCACTTTTCAAAATGATTGACTTAAGCTTCCTGACT
GAAGAGGAACAAGAGGCCATCATGAAGGTTTTGCAGCGGGATGCTGCTCTGAAGAGGGCCGAAGAAGAGAGAGTCAGACATTTGCCTGAAAAAATTAAGG
ATGACCAGCAGCTGAAGAATATGAGTGGCCAATGGTTTTATGAAGCCAAGGCAAAAAGGCACAGGGACAAAATCCATGGCGCAGATATCATCAGAGCATC
TATGAGAAAGAAGAGGCCCCAGATAGCAGCTGAGCAGAGTAAAGACAGAGAAAATGGGGCAAAGGAAAGCTGGGTGAATAATGTCAACAAAGATGCTTTC
CTTCCTCCAGAGCTGGCTGGCGTTGTAGAAGAGCCAGAAGAAGATGCAGCACCAGCAAGCCCGAGTTCCAGTGTGGTAAATCCAGCTTCCAGTGTGATTG
ATATGTCCCAGGAAAACACAAGGAAACCAAATGTGTCTCCAGAGAAGAGGAAGAATCCGTTTAATAGCTCCAAGTTGCCAGAAGGTCACTCATCACAACA
AACTAAAAATGAACAGTCAAAAAATGGAAGAACTGGTTTATTTCAGACTTCAAAAGAGGATGAATTGTCAGAGTCAAAAGAAAAGTCAACTGTCGCAGAT
ACTTCAATCCAAAAGTTAGAGAAATCAAAGCAGACTTTGCCAGGCCTTTCAAATGGGTCCCAAATCAAGGCTCCAATCCCCAAAGCCAGGAAGATGATCT
ACAAATCAACTGATTTAAACAAAGATGATAACCAGTCTTTTCCTAGACAAAGGACAGACTCCCTGAAAGCGAGAGGGGCTCCGAGAGGGATCCTCAAGCG
CAACTCCAGTTCCAGTAGCACAGACTCAGAAACCCTTCGTTATAATCACAACTTTGAACCCAAAAGCAAAATTGTGTCACCTGGCCTAACCATCCATGAG
AGAATTTCTGAGAAGGAGCATTCTTTAGAAGACAACTCTTCCCCAAACTCCCTGGAGCCATTAAAGCATGTGAGATTCTCTGCAGTGAAGGATGAGCTTC
CACAGAGTCCTGGGCTAATCCATGGTCGGGAAGTAGGAGAATTTAGTGTTTTAGAATCTGACAGATTGAAAAATGGAATGGAAGATGCAGGGGACACAGA
AGAGTTTCAGAGTGACCCTAAGCCTTCTCAATACAGAAAGCCTTCGCTTTTTCATCAATCAACCTCAAGCCCATATGTATCAAAAAGTGAAACACATCAG
CCAATGACTTCTGGTTCTTTTCCAATTAATGGGCTGCATTCTCATTCAGAAGTTTTAACTGCAAGACCACAGTCTATGGAGAATTCACCAACCATCAATG
AACCCAAAGATAAATCATCAGAATTAACAAGGCTTGAATCTGTATTACCCAGAAGCCCTGCTGATGAACTGTCTCATTGTGTTGAGCCTGAGCCATCTCA
GGTGCCAGGTGGCAGTTCTAGAGACCGTCAGCAAGGTTCAGAAGAAGAACCCAGTCCTGTTTTGAAAACTTTGGAAAGGAGTGCCGCTAGGAAAATGCCT
TCCAAAAGTCTAGAAGACATTTCATCAGATTCATCAAATCAAGCAAAAGTAGATAATCAGCCAGAAGAATTAGTGCGTAGTGCTGAAGATGATGAGAAAC
CAGATCAGAAGCCAGTTACAAATGAATGCGTACCAAGAATTTCCACAGTGCCTACACAACCTGATAATCCATTTTCTCACCCTGACAAACTCAAAAGGAT
GAGCAAGTCTGTTCCAGCATTTCTCCAAGATGAGGTGAGTGGCAGTGTGATGAGTGTTTATAGTGGAGACTTTGGCAATCTGGAAGTTAAAGGAAATATT
CAGTTTGCAATTGAATATGTGGAGTCACTGAAGGAGTTGCATGTTTTTGTGGCCCAGTGTAAGGACTTAGCAGCAGCGGATGTAAAAAAACAGCGTTCAG
ACCCATATGTAAAGGCCTATTTGCTACCAGACAAAGGCAAAATGGGCAAGAAGAAAACACTCGTAGTGAAGAAAACCTTGAATCCTGTGTATAACGAAAT
ACTGCGGTATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAG
GTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAG
CAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAA
GGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACA
AGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTG
TCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTC
TACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATT
TCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTT
TCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATG
TGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAA
CATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGA
CCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAG
AAACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGT
TAAAACAAGCCTCAAATGTATTTTAGTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCT
GTATTTTTATGAGTTTATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATG
TTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAAACCCTTAGAATAAAT
TATCATTTGATTTAAATTGTATTAGAAAATTAGCGTGACTTCTCATTTTAAATAAAATATTTTAGGAATTCTAAACATCTAAA
  • refseq_SYTL2.F1 (forward primer)
  • refseq_SYTL2.R1 (reverse primer)
  • Single exon skipping

Frame 0

NKRPVWQGIQHPSESLFSTLSHRPGLPHGKEHL
GSCYQLP*TFAEPK*DFDAELNKIFHFCVF*SSW
LQS*LFSPENFEPHLLLLFLHALFKMIDLSFLT
EEEQEAIMKVLQRDAALKRAEEERVRHLPEKIK
DDQQLKNMSGQWFYEAKAKRHRDKIHGADIIRAS
MRKKRPQIAAEQSKDRENGAKESWVNNVNKDAF
LPPELAGVVEEPEEDAAPASPSSSVVNPASSVI
DMSQENTRKPNVSPEKRKNPFNSSKLPEGHSSQQ
TKNEQSKNGRTGLFQTSKEDELSESKEKSTVAD
TSIQKLEKSKQTLPGLSNGSQIKAPIPKARKMI
YKSTDLNKDDNQSFPRQRTDSLKARGAPRGILKR
NSSSSSTDSETLRYNHNFEPKSKIVSPGLTIHE
RISEKEHSLEDNSSPNSLEPLKHVRFSAVKDEL
PQSPGLIHGREVGEFSVLESDRLKNGMEDAGDTE
EFQSDPKPSQYRKPSLFHQSTSSPYVSKSETHQ
PMTSGSFPINGLHSHSEVLTARPQSMENSPTIN
EPKDKSSELTRLESVLPRSPADELSHCVEPEPSQ
VPGGSSRDRQQGSEEEPSPVLKTLERSAARKMP
SKSLEDISSDSSNQAKVDNQPEELVRSAEDDEK
PDQKPVTNECVPRISTVPTQPDNPFSHPDKLKRM
SKSVPAFLQDEVSGSVMSVYSGDFGNLEVKGNI
QFAIEYVESLKELHVFVAQCKDLAAADVKKQRS
DPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEI
LRYKIEKQILKTQKLNLSIWHRDTFKRNSFLGE
VELDLETWDWDNKQNKQLRWYPLKRKTAPVALE
AENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVK
ECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKT
RAVGKTTNPIFNHTMVYDGFRPEDLMEACVELT
VWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDS
TSEEVALWEKMVNSPNTWIEATLPLRMLLIAKI
SK*AQIPLAPPLKTTKPVESDLENLSRWTNILT
FYLLHLRNTTQHVKVNLHVLL*LQGPRDLNITKC
VICDSNIK*DI*TS*EN*ISAAASKKKLPQSIK
HGVLLRSKMFLFAIMCFTPQFCATVKRVWYPCR
TFVGCGKKSQKDTQSGAGNGDRHQ***KKKWTLR
NYLLCNL**NMEFHIRAMRLKLLVFFCLEKTNS
*NKPQMYFSATHWP*VQFSCWLVLT*F*NRSQA
CIFMSLFF*NPAYI*LFFL*LYYMKAA*E*SQTC
FATKF*LECKLLSYTVLLMYVKFSYFVKTLRIN
YHLI*IVLEN*RDFSF*IKYFRNSKHL

Frame 1

TSDLFGKEYSILLRASSRHYPTDQDFLMGKST*
DLAISCPKLLLSQNKTLMQN*TRYFIFVCFNLP
GCSLSCSALRILSHICCYYFCMHFSK*LT*AS*L
KRNKRPS*RFCSGMLL*RGPKKRESDICLKKLR
MTSS*RI*VANGFMKPRQKGTGTKSMAQISSEH
L*ERRGPR*QLSRVKTEKMGQRKAG*IMSTKMLS
FLQSWLAL*KSQKKMQHQQARVPVW*IQLPV*L
ICPRKTQGNQMCLQRRGRIRLIAPSCQKVTHHN
KLKMNSQKMEELVYFRLQKRMNCQSQKKSQLSQI
LQSKS*RNQSRLCQAFQMGPKSRLQSPKPGR*S
TNQLI*TKMITSLFLDKGQTP*KREGLREGSSS
ATPVPVAQTQKPFVIITTLNPKAKLCHLA*PSMR
EFLRRSIL*KTTLPQTPWSH*SM*DSLQ*RMSF
HRVLG*SMVGK*ENLVF*NLTD*KMEWKMQGTQ
KSFRVTLSLLNTESLRFFINQPQAHMYQKVKHIS
Q*LLVLFQLMGCILIQKF*LQDHSLWRIHQPSM
NPKINHQN*QGLNLYYPEALLMNCLIVLSLSHL
RCQVAVLETVSKVQKKNPVLF*KLWKGVPLGKCL
PKV*KTFHQIHQIKQK*IISQKN*CVVLKMMRN
QIRSQLQMNAYQEFPQCLHNLIIHFLTLTNSKG
*ASLFQHFSKMR*VAV**VFIVETLAIWKLKEIF
SLQLNMWSH*RSCMFLWPSVRT*QQRM*KNSVQ
THM*RPICYQTKAKWARRKHS**RKP*ILCITK
YCGIKLKNKS*RHRN*TCPFGIGIHLSAIVS*GR
WNLIWKHGTGITNRINN*DGTL*SGRQHQLPLK
QKTEVK*N*LSSMSQSQSLVKSFLQLEKCTSG*
RNALIYHC*GEVI*ILLLNVPSFQIQVGKVARRQ
EL*GKPPTLSSTTLWCMMGSGLKI*WKPV*SLL
SGTITN*PTNFWEVFVLALEQVKVMGLKWTGWT
LLQRKLLSGRRW*TPPILGLKQHCLSECF*LPRF
PNEPKFHWLLH*KLLNRWNLILKI*VGGQISSL
SIYCT*GILHSM*KSICMCFFDYKAQGI*I*QN
V*FVTLILNKIFEQARKIEFLLLLQRKSCPRALN
MGYC*EAKCSCLPSCVSHHNSVPQLRGSGTLAG
PL*VVGKSRRKILKVEQGMETDISDDKKKNGP*
ETIYSVISNKIWNSILGQ*D*NYWCFSALRKQTV
KTSLKCILVPPTGHRYNSVVGLF*LNSKIGLKP
VFL*VYFFKTLHIYDCFSYNFTI*KQHKSSHKH
VLQQSFN*NVSCSVILFFLCM*NFRIL*KPLE*I
II*FKLY*KISVTSHFK*NILGILNI*

Frame 2

QATCLARNTASF*EPLLDTIPQTRTSSWERALR
ILLSAALNFC*AKIRL*CRTEQDISFLCVLIFL
VAVLVVQP*EF*ATFVAIIFACTFQND*LKLPD
*RGTRGHHEGFAAGCCSEEGRRRESQTFA*KN*G
*PAAEEYEWPMVL*SQGKKAQGQNPWRRYHQSI
YEKEEAPDSS*AE*RQRKWGKGKLGE*CQQRCF
PSSRAGWRCRRARRRCSTSKPEFQCGKSSFQCD*
YVPGKHKETKCVSREEEESV**LQVARRSLITT
N*K*TVKKWKNWFISDFKRG*IVRVKRKVNCRR
YFNPKVREIKADFARPFKWVPNQGSNPQSQEDDL
QIN*FKQR**PVFS*TKDRLPESERGSERDPQA
QLQFQ*HRLRNPSL*SQL*TQKQNCVTWPNHP*
ENF*EGAFFRRQLFPKLPGAIKACEILCSEG*AS
TESWANPWSGSRRI*CFRI*QIEKWNGRCRGHR
RVSE*P*AFSIQKAFAFSSINLKPICIKK*NTS
ANDFWFFSN*WAAFSFRSFNCKTTVYGEFTNHQ*
TQR*IIRINKA*ICITQKPC**TVSLC*A*AIS
GARWQF*RPSARFRRRTQSCFENFGKECR*ENA
FQKSRRHFIRFIKSSKSR*SARRISA*C*R**ET
RSEASYK*MRTKNFHSAYTT**SIFSP*QTQKD
EQVCSSISPR*GEWQCDECL*WRLWQSGS*RKY
SVCN*ICGVTEGVACFCGPV*GLSSSGCKKTAFR
PICKGLFATRQRQNGQEENTRSEENLESCV*RN
TAV*N*KTNLKDTEIEPVHLASGYI*AQ*FPRG
GGT*FGNMGLG*QTE*TIEMVPSEAEDSTSCP*S
RKQR*NETSSPVCPRASPW*KASYNWRSAHLGE
GMP*STTAKGKSSKFFC*MYHPSRYK*EKSPED
KSCRENHQPYLQPHYGV*WVQA*RSDGSLCRAYC
LGPLQINQPIFGRSSYWLWNR*KLWD*SGLDGL
YFRGSCSLGEDGKLPQYLD*SNTASQNAFDCQD
FQMSPNSTGSSTENY*TGGI*S*KSE*VDKYPHF
LSIAPKEYYTACKSQSACASLITRPKGFKYNKM
CNL*L*Y*IRYLNKLGKLNFCCCFKEKAAPEH*
TWGIVKKQNVLVCHHVFHTTILCHS*EGLVPLQD
LCRLWEKVAERYSKWSREWRQTSVMIKKKMDLK
KLFTL*SLIKYGIPY*GNETETTGVFLP*ENKQ
LKQASNVF*CHPLAIGTIQLLACFDLILK*VSSL
YFYEFIFLKPCIYMIVFLITLLYESSIRVVTNM
FCNKVLIRM*VAQLYCSSYVCKIFVFCKNP*NK
LSFDLNCIRKLA*LLILNKIF*EF*TSK

Sequence NM_206928

CTAAAAGAAAGAATGGATGAACCCAATGCAGAACAGGTCTATAATCCCTCTCAGTTTGAGAATTTGAGAAAGTTTTGGGACTTAGAAGCTAATTCAAACA
GTAAGGATAATGACAAGAATATTACCACCACAAGCCAAAAAAATTCTGCACCTTTTAATAGGCAGAAACACAAGGAATTCAGCGACATTAAATTATCAGG
TAAAAATACCCATGAAGCAGAGGTGCTTCTAAGCCCAAAAAAAGTTATGGCAAGAGAGGAAATGGAGAAATTAAATTCAAAGGGCATACTCCAGGTGCTA
CCAGATGAAATCACATTTCCTTTGAGTCCACTTAGAAAGTATACTTATCAGTTGCCAGGAAATGAGTCATCAAAGGAAAATGTGGAAAAGAATACGGAAG
GGATTGTTACTCCAGTGTTTAAGGAAGAAAAGGATTACTCAGAACAAGAGATTCAAGAATCCATAATAAAAACCAATGTTTTGTCTAAAGACTGCAAAGA
CACTTTTAATGACAGCTTGCAGAAACTGCTTTCAGAAACCTCAACACCAGCAATTCAACCCTCTGGTGGAAAAGTTCATGGAAAACAAGTGCTTGAACCA
AGTGTTTCTGAAAATAGGACATGGCCTCAAAAAACAGATTTTGCTGATACTGAGGAAGAAGTCAAAGGACCTGAGAAGATCATTAATGAGCATGTTGACA
AAACAGTAGTTCATCCAAAGGTTAAACGGAACTCTTTGACTGCTAGTCTAGACAAACTCCTGAAGGAAGCAACTGGAACTTCACCCTCTCCCTTGCAAGC
CAAGTTGGCGCCTGTTATCACTGGAACCAACTCTAAGCTGGAAGAGGGGAGATTTTTTGGAAAAGGGATAGAACAGAGTCACAATACTTCAGCTGATAAG
AGAGAAATACTAGCTCCTTTTCCAGTGAGAGATGAAACTTTTGGAAATACAGCTCTCCTCAAGAAAGCTGAAAGTGGTGAGTGCCAGCTAAGCACACAGA
ATTTGATTCAGATGGCTGCAGAAGATTCTCATCCATTGGATCCAACTTCCCAGCTTTCCAGAAAGGGTTCTTTTGGGGATGTGGCCAGCCCTCCCCAAGA
TATGCTTTTTCCCCAGGATGCTCATCTTGTTCCCCAGGCTAGGGTACACCCTTCTCAAACGGAAATTTCGGAGACTGTAGAGAAAGTCATTCTTCCACCC
AGACCTGTATTGAATGATGTAAGTGCTGCATTACAGAAGCTGTGTGGAGAAGTATGGTTAAGTTATCCAGCTGGAAGGGAAGTAGGTCCTGGAGAAGTGA
ACCCAGAATTTCCTGAAGCAGTACAGCCAGTATGTAGCCCCCTAAATCCTCCAGGAGTGATATCACCATGGGCTACGATGGACACCATAGTTCCAGACAG
GAAGGATTTTTATTCCTCCAATGTAGTTCCTGATAAAACTCATGAAGTTGGATCTTATTTAGCTGCCCAAATGTCTCCATCAGACCAGACGCTTAGCTCA
TTTGCTTCCATTGTTGCTCAATATGGCAAAGGCCTCCCTCAGGAAGTGGAAGAAATTGTGAGGGAAACAATTGTTCAACCCAAATCAGAGTTCCTCGAAT
TCAGTGCTGGCTTAGAAAAACTACTGAAGGAAGAAACTGAAACCTTCCCCTCAAAATATGAAAGTGATACAGGGAATCTTTCTCCATCAAAGTTAATAGG
TAGTACAGAGGAGCCCAGGCGAGCCACTTCTGAATGCCATCCTGAGGAATTAAAAGAAACAGTAGAAAAGGCCGAGGCTCCGTTAATAACTGAGAGTGCT
TTTGATGCTGGTTTTGAGAAACTTCTTAAAGAAATAACTGAAGCTCCTCCTTATCAGCCCCAGGTGTCAGTGAGAGAAGAAACTCACGAGAAGGAGTCCT
CACAGTCAGAGCAGACCAGGTTCTTGGGGACAGTGCCCCATTTTTACAGGGCAGCCTCACAGACCTCTGAAATGAAGGATAAAAGTAATGGTTTGGAATC
TCAAGTCAACCAATGTGATAAAATGTTGGGAGGAGACGCACTTGTGACTGATTTATTGGTAGATTTTTGTGGTTCCAGAAGTGGAGTTGAGATCCCTAGA
ACCCCACAACTTTATGTGGCTCATGAAATAGGGACCATTAAAACTGTAACCCCCCCAGAGGACAGGGACAGTGAAAGTGGGGTTGCAGGGGGACAAGGGA
CTCTTCAGGAACCTGGCTTTGGAGAGGCTTCTGAAGCAATTAGTGTGTCCAGAAATAGGCAACCCATTCCTCTCCTGATGAACAAAGAAAACTCTACAAA
AACAAGTAAAGTTGAATTGACTCTAGCATCGCCATATATGAAACAAGAGAAAGAGGAAGAAAAAGAAGGTTTCTCTGAGTCTGATTTTTCAGATGGAAAC
ACCAGTTCTAATGCAGAGAGCTGGAGAAATCCTTCCAGTTCAGAAGAAGAACCCAGTCCTGTTTTGAAAACTTTGGAAAGGAGTGCCGCTAGGAAAATGC
CTTCCAAAAGTCTAGAAGACATTTCATCAGATTCATCAAATCAAGCAAAAGTAGATAATCAGCCAGAAGAATTAGTGCGTAGTGCTGAAGATGTTTCCAC
AGTGCCTACACAACCTGATAATCCATTTTCTCACCCTGACAAACTCAAAAGGATGAGCAAGTCTGTTCCAGCATTTCTCCAAGATGAGAGTGATGACAGA
GAAACAGATACAGCATCAGAAAGCAGTTACCAGCTCAGCAGACACAAGAAGAGCCCGAGCTCTTTAACCAATCTTAGCAGCTCCTCTGGCATGACGTCCT
TGTCTTCTGTGAGTGGCAGTGTGATGAGTGTTTATAGTGGAGACTTTGGCAATCTGGAAGTTAAAGGAAATATTCAGTTTGCAATTGAATATGTGGAGTC
ACTGAAGGAGTTGCATGTTTTTGTGGCCCAGTGTAAGGACTTAGCAGCAGCGGATGTAAAAAAACAGCGTTCAGACCCATATGTAAAGGCCTATTTGCTA
CCAGACAAAGGCAAAATGGGCAAGAAGAAAACACTCGTAGTGAAGAAAACCTTGAATCCTGTGTATAACGAAATACTGCGGTATAAAATTGAAAAACAAA
TCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGA
CTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTA
GCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAA
GGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCC
TATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAAC
CAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGG
AGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGC
TCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACT
ACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAAT
AAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAAT
GTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCG
CAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAAT
AAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTAG
TGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTTTTAA
AACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAAT
GTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAAACCCTTAGAATAAATTATCATTTGATTTAAATTGTATTAGA
AAATTAGCGTGACTTCTCATTTTAAATAAAATATTTTAGGAATTCTAAACATCTAAA
  • refseq_SYTL2.F1 (forward primer)
  • refseq_SYTL2.R1 (reverse primer)
  • Single exon skipping

Frame 0

LKERMDEPNAEQVYNPSQFENLRKFWDLEANSN
SKDNDKNITTTSQKNSAPFNRQKHKEFSDIKLSG
KNTHEAEVLLSPKKVMAREEMEKLNSKGILQVL
PDEITFPLSPLRKYTYQLPGNESSKENVEKNTE
GIVTPVFKEEKDYSEQEIQESIIKTNVLSKDCKD
TFNDSLQKLLSETSTPAIQPSGGKVHGKQVLEP
SVSENRTWPQKTDFADTEEEVKGPEKIINEHVD
KTVVHPKVKRNSLTASLDKLLKEATGTSPSPLQA
KLAPVITGTNSKLEEGRFFGKGIEQSHNTSADK
REILAPFPVRDETFGNTALLKKAESGECQLSTQ
NLIQMAAEDSHPLDPTSQLSRKGSFGDVASPPQD
MLFPQDAHLVPQARVHPSQTEISETVEKVILPP
RPVLNDVSAALQKLCGEVWLSYPAGREVGPGEV
NPEFPEAVQPVCSPLNPPGVISPWATMDTIVPDR
KDFYSSNVVPDKTHEVGSYLAAQMSPSDQTLSS
FASIVAQYGKGLPQEVEEIVRETIVQPKSEFLE
FSAGLEKLLKEETETFPSKYESDTGNLSPSKLIG
STEEPRRATSECHPEELKETVEKAEAPLITESA
FDAGFEKLLKEITEAPPYQPQVSVREETHEKES
SQSEQTRFLGTVPHFYRAASQTSEMKDKSNGLES
QVNQCDKMLGGDALVTDLLVDFCGSRSGVEIPR
TPQLYVAHEIGTIKTVTPPEDRDSESGVAGGQG
TLQEPGFGEASEAISVSRNRQPIPLLMNKENSTK
TSKVELTLASPYMKQEKEEEKEGFSESDFSDGN
TSSNAESWRNPSSSEEEPSPVLKTLERSAARKM
PSKSLEDISSDSSNQAKVDNQPEELVRSAEDVST
VPTQPDNPFSHPDKLKRMSKSVPAFLQDESDDR
ETDTASESSYQLSRHKKSPSSLTNLSSSSGMTS
LSSVSGSVMSVYSGDFGNLEVKGNIQFAIEYVES
LKELHVFVAQCKDLAAADVKKQRSDPYVKAYLL
PDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQ
ILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWD
WDNKQNKQLRWYPLKRKTAPVALEAENRGEMKL
ALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLL
RGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNP
IFNHTMVYDGFRPEDLMEACVELTVWDHYKLTN
QFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALW
EKMVNSPNTWIEATLPLRMLLIAKISK*AQIPLA
PPLKTTKPVESDLENLSRWTNILTFYLLHLRNT
TQHVKVNLHVLL*LQGPRDLNITKCVICDSNIK
*DI*TS*EN*ISAAASKKKLPQSIKHGVLLRSKM
FLFAIMCFTPQFCATVKRVWYPCRTFVGCGKKS
QKDTQSGAGNGDRHQ***KKKWTLRNYLLCNL*
*NMEFHIRAMRLKLLVFFCLEKTNS*NKPQMYFS
ATHWP*VQFSCWLVLT*F*NRSQACIFMSLFF*
NPAYI*LFFL*LYYMKAA*E*SQTCFATKF*LE
CKLLSYTVLLMYVKFSYFVKTLRINYHLI*IVLE
N*RDFSF*IKYFRNSKHL

Frame 1

*KKEWMNPMQNRSIIPLSLRI*ESFGT*KLIQT
VRIMTRILPPQAKKILHLLIGRNTRNSATLNYQ
VKIPMKQRCF*AQKKLWQERKWRN*IQRAYSRCY
QMKSHFL*VHLESILISCQEMSHQRKMWKRIRK
GLLLQCLRKKRITQNKRFKNP**KPMFCLKTAK
TLLMTACRNCFQKPQHQQFNPLVEKFMENKCLNQ
VFLKIGHGLKKQILLILRKKSKDLRRSLMSMLT
KQ*FIQRLNGTL*LLV*TNS*RKQLELHPLPCK
PSWRLLSLEPTLSWKRGDFLEKG*NRVTILQLIR
EKY*LLFQ*EMKLLEIQLSSRKLKVVSAS*AHR
I*FRWLQKILIHWIQLPSFPERVLLGMWPALPK
ICFFPRMLILFPRLGYTLLKRKFRRL*RKSFFHP
DLY*MM*VLHYRSCVEKYG*VIQLEGK*VLEK*
TQNFLKQYSQYVAP*ILQE*YHHGLRWTP*FQT
GRIFIPPM*FLIKLMKLDLI*LPKCLHQTRRLAH
LLPLLLNMAKASLRKWKKL*GKQLFNPNQSSSN
SVLA*KNY*RKKLKPSPQNMKVIQGIFLHQS**
VVQRSPGEPLLNAILRN*KKQ*KRPRLR**LRVL
LMLVLRNFLKK*LKLLLISPRCQ*EKKLTRRSP
HSQSRPGSWGQCPIFTGQPHRPLK*RIKVMVWN
LKSTNVIKCWEETHL*LIYW*IFVVPEVELRSLE
PHNFMWLMK*GPLKL*PPQRTGTVKVGLQGDKG
LFRNLALERLLKQLVCPEIGNPFLS**TKKTLQ
KQVKLN*L*HRHI*NKRKRKKKKVSLSLIFQMET
PVLMQRAGEILPVQKKNPVLF*KLWKGVPLGKC
LPKV*KTFHQIHQIKQK*IISQKN*CVVLKMFP
QCLHNLIIHFLTLTNSKG*ASLFQHFSKMRVMTE
KQIQHQKAVTSSADTRRARAL*PILAAPLA*RP
CLL*VAV**VFIVETLAIWKLKEIFSLQLNMWS
H*RSCMFLWPSVRT*QQRM*KNSVQTHM*RPICY
QTKAKWARRKHS**RKP*ILCITKYCGIKLKNK
S*RHRN*TCPFGIGIHLSAIVS*GRWNLIWKHG
TGITNRINN*DGTL*SGRQHQLPLKQKTEVK*N*
LSSMSQSQSLVKSFLQLEKCTSG*RNALIYHC*
GEVI*ILLLNVPSFQIQVGKVARRQEL*GKPPT
LSSTTLWCMMGSGLKI*WKPV*SLLSGTITN*PT
NFWEVFVLALEQVKVMGLKWTGWTLLQRKLLSG
RRW*TPPILGLKQHCLSECF*LPRFPNEPKFHW
LLH*KLLNRWNLILKI*VGGQISSLSIYCT*GIL
HSM*KSICMCFFDYKAQGI*I*QNV*FVTLILN
KIFEQARKIEFLLLLQRKSCPRALNMGYC*EAK
CSCLPSCVSHHNSVPQLRGSGTLAGPL*VVGKSR
RKILKVEQGMETDISDDKKKNGP*ETIYSVISN
KIWNSILGQ*D*NYWCFSALRKQTVKTSLKCIL
VPPTGHRYNSVVGLF*LNSKIGLKPVFL*VYFFK
TLHIYDCFSYNFTI*KQHKSSHKHVLQQSFN*N
VSCSVILFFLCM*NFRIL*KPLE*III*FKLY*
KISVTSHFK*NILGILNI*

Frame 2

KRKNG*TQCRTGL*SLSV*EFEKVLGLRS*FKQ
*G**QEYYHHKPKKFCTF**AETQGIQRH*IIR
*KYP*SRGASKPKKSYGKRGNGEIKFKGHTPGA
TR*NHISFEST*KVYLSVARK*VIKGKCGKEYGR
DCYSSV*GRKGLLRTRDSRIHNKNQCFV*RLQR
HF**QLAETAFRNLNTSNSTLWWKSSWKTSA*T
KCF*K*DMASKNRFC*Y*GRSQRT*EDH**AC*Q
NSSSSKG*TELFDC*SRQTPEGSNWNFTLSLAS
QVGACYHWNQL*AGRGEIFWKRDRTESQYFS**
ERNTSSFSSER*NFWKYSSPQES*KW*VPAKHTE
FDSDGCRRFSSIGSNFPAFQKGFFWGCGQPSPR
YAFSPGCSSCSPG*GTPFSNGNFGDCRESHSST
QTCIE*CKCCITEAVWRSMVKLSSWKGSRSWRSE
PRIS*SSTASM*PPKSSRSDITMGYDGHHSSRQ
EGFLFLQCSS**NS*SWILFSCPNVSIRPDA*L
ICFHCCSIWQRPPSGSGRNCEGNNCSTQIRVPRI
QCWLRKTTEGRN*NLPLKI*K*YRESFSIKVNR
*YRGAQASHF*MPS*GIKRNSRKGRGSVNN*EC
F*CWF*ETS*RNN*SSSLSAPGVSERRNSREGVL
TVRADQVLGDSAPFLQGSLTDL*NEG*K*WFGI
SSQPM**NVGRRRTCD*FIGRFLWFQKWS*DP*
NPTTLCGS*NRDH*NCNPPRGQGQ*KWGCRGTRD
SSGTWLWRGF*SN*CVQK*ATHSSPDEQRKLYK
NK*S*IDSSIAIYETRERGRKRRFL*V*FFRWK
HQF*CRELEKSFQFRRRTQSCFENFGKECR*ENA
FQKSRRHFIRFIKSSKSR*SARRISA*C*RCFH
SAYTT**SIFSP*QTQKDEQVCSSISPR*E**Q
RNRYSIRKQLPAQQTQEEPELFNQS*QLLWHDVL
VFCEWQCDECL*WRLWQSGS*RKYSVCN*ICGV
TEGVACFCGPV*GLSSSGCKKTAFRPICKGLFA
TRQRQNGQEENTRSEENLESCV*RNTAV*N*KTN
LKDTEIEPVHLASGYI*AQ*FPRGGGT*FGNMG
LG*QTE*TIEMVPSEAEDSTSCP*SRKQR*NET
SSPVCPRASPW*KASYNWRSAHLGEGMP*STTAK
GKSSKFFC*MYHPSRYK*EKSPEDKSCRENHQP
YLQPHYGV*WVQA*RSDGSLCRAYCLGPLQINQ
PIFGRSSYWLWNR*KLWD*SGLDGLYFRGSCSLG
EDGKLPQYLD*SNTASQNAFDCQDFQMSPNSTG
SSTENY*TGGI*S*KSE*VDKYPHFLSIAPKEY
YTACKSQSACASLITRPKGFKYNKMCNL*L*Y*I
RYLNKLGKLNFCCCFKEKAAPEH*TWGIVKKQN
VLVCHHVFHTTILCHS*EGLVPLQDLCRLWEKV
AERYSKWSREWRQTSVMIKKKMDLKKLFTL*SLI
KYGIPY*GNETETTGVFLP*ENKQLKQASNVF*
CHPLAIGTIQLLACFDLILK*VSSLYFYEFIFL
KPCIYMIVFLITLLYESSIRVVTNMFCNKVLIRM
*VAQLYCSSYVCKIFVFCKNP*NKLSFDLNCIR
KLA*LLILNKIF*EF*TSK

Sequence NM_032379

GTTTTTAAAATTAACTTTGTTTTGTATTTGGTTCAACTCCTTGCTAGTTCTCTCTCTATATAATTTATAAAAACTGCATGTTGCTAATCTCATGATCCTG
TGCATGTGGACTACTCTGCCTTTAACTTTTTTACAAAAACATGTTTGTTCATAGATTAAATAAAAGTATGTTTTCAACTTAATGTCTAATGTTTTCTGAC
AATTGTAAGAATAATTTTGAAATGGAAATGCTGCTGTTTAGTTTCCACAGTGCCTACACAACCTGATAATCCATTTTCTCACCCTGACAAACTCAAAAGG
ATGAGCAAGTCTGTTCCAGCATTTCTCCAAGATGAGAGTGATGACAGAGAAACAGATACAGCATCAGAAAGCAGTTACCAGCTCAGCAGACACAAGAAGA
GCCCGAGCTCTTTAACCAATCTTAGCAGCTCCTCTGGCATGACGTCCTTGTCTTCTGTGAGTGGCAGTGTGATGAGTGTTTATAGTGGAGACTTTGGCAA
TCTGGAAGTTAAAGGAAATATTCAGTTTGCAATTGAATATGTGGAGTCACTGAAGGAGTTGCATGTTTTTGTGGCCCAGTGTAAGGACTTAGCAGCAGCG
GATGTAAAAAAACAGCGTTCAGACCCATATGTAAAGGCCTATTTGCTACCAGACAAAGGCAAAATGGGCAAGAAGAAAACACTCGTAGTGAAGAAAACCT
TGAATCCTGTGTATAACGAAATACTGCGGTATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAA
GCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAG
ACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTG
GAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAG
TAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATG
GAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGA
CTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAG
AATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGT
AGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAA
GGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAA
AAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAG
AGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGAT
AAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTT
CTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAA
TTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAG
CATAAGAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTT
TGTAAAAACCCTTAGAATAAATTATCATTTGATTTAAATTGTATTAGAAAATTAGCGTGACTTCTCATTTTAAATAAAATATTTTAGGAATTCTAAACAT
CTAAA
  • refseq_SYTL2.F1 (forward primer)
  • refseq_SYTL2.R1 (reverse primer)
  • Single exon skipping

Frame 0

VFKINFVLYLVQLLASSLSI*FIKTACC*SHDP
VHVDYSAFNFFTKTCLFID*IKVCFQLNV*CFLT
IVRIILKWKCCCLVSTVPTQPDNPFSHPDKLKR
MSKSVPAFLQDESDDRETDTASESSYQLSRHKK
SPSSLTNLSSSSGMTSLSSVSGSVMSVYSGDFGN
LEVKGNIQFAIEYVESLKELHVFVAQCKDLAAA
DVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKT
LNPVYNEILRYKIEKQILKTQKLNLSIWHRDTFK
RNSFLGEVELDLETWDWDNKQNKQLRWYPLKRK
TAPVALEAENRGEMKLALQYVPEPVPGKKLPTT
GEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTS
RKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLM
EACVELTVWDHYKLTNQFLGGLRIGFGTGKSYG
TEVDWMDSTSEEVALWEKMVNSPNTWIEATLPLR
MLLIAKISK*AQIPLAPPLKTTKPVESDLENLS
RWTNILTFYLLHLRNTTQHVKVNLHVLL*LQGP
RDLNITKCVICDSNIK*DI*TS*EN*ISAAASKK
KLPQSIKHGVLLRSKMFLFAIMCFTPQFCATVK
RVWYPCRTFVGCGKKSQKDTQSGAGNGDRHQ**
*KKKWTLRNYLLCNL**NMEFHIRAMRLKLLVFF
CLEKTNS*NKPQMYFSATHWP*VQFSCWLVLT*
F*NRSQACIFMSLFF*NPAYI*LFFL*LYYMKA
A*E*SQTCFATKF*LECKLLSYTVLLMYVKFSYF
VKTLRINYHLI*IVLEN*RDFSF*IKYFRNSKH
L

Frame 1

FLKLTLFCIWFNSLLVLSLYNL*KLHVANLMIL
CMWTTLPLTFLQKHVCS*IK*KYVFNLMSNVF*
QL*E*F*NGNAAV*FPQCLHNLIIHFLTLTNSKG
*ASLFQHFSKMRVMTEKQIQHQKAVTSSADTRR
ARAL*PILAAPLA*RPCLL*VAV**VFIVETLA
IWKLKEIFSLQLNMWSH*RSCMFLWPSVRT*QQR
M*KNSVQTHM*RPICYQTKAKWARRKHS**RKP
*ILCITKYCGIKLKNKS*RHRN*TCPFGIGIHL
SAIVS*GRWNLIWKHGTGITNRINN*DGTL*SGR
QHQLPLKQKTEVK*N*LSSMSQSQSLVKSFLQL
EKCTSG*RNALIYHC*GEVI*ILLLNVPSFQIQ
VGKVARRQEL*GKPPTLSSTTLWCMMGSGLKI*W
KPV*SLLSGTITN*PTNFWEVFVLALEQVKVMG
LKWTGWTLLQRKLLSGRRW*TPPILGLKQHCLS
ECF*LPRFPNEPKFHWLLH*KLLNRWNLILKI*V
GGQISSLSIYCT*GILHSM*KSICMCFFDYKAQ
GI*I*QNV*FVTLILNKIFEQARKIEFLLLLQR
KSCPRALNMGYC*EAKCSCLPSCVSHHNSVPQLR
GSGTLAGPL*VVGKSRRKILKVEQGMETDISDD
KKKNGP*ETIYSVISNKIWNSILGQ*D*NYWCF
SALRKQTVKTSLKCILVPPTGHRYNSVVGLF*LN
SKIGLKPVFL*VYFFKTLHIYDCFSYNFTI*KQ
HKSSHKHVLQQSFN*NVSCSVILFFLCM*NFRI
L*KPLE*III*FKLY*KISVTSHFK*NILGILNI
*

Frame 2

F*N*LCFVFGSTPC*FSLYIIYKNCMLLIS*SC
ACGLLCL*LFYKNMFVHRLNKSMFST*CLMFSD
NCKNNFEMEMLLFSFHSAYTT**SIFSP*QTQK
DEQVCSSISPR*E**QRNRYSIRKQLPAQQTQEE
PELFNQS*QLLWHDVLVFCEWQCDECL*WRLWQ
SGS*RKYSVCN*ICGVTEGVACFCGPV*GLSSS
GCKKTAFRPICKGLFATRQRQNGQEENTRSEENL
ESCV*RNTAV*N*KTNLKDTEIEPVHLASGYI*
AQ*FPRGGGT*FGNMGLG*QTE*TIEMVPSEAE
DSTSCP*SRKQR*NETSSPVCPRASPW*KASYNW
RSAHLGEGMP*STTAKGKSSKFFC*MYHPSRYK
*EKSPEDKSCRENHQPYLQPHYGV*WVQA*RSD
GSLCRAYCLGPLQINQPIFGRSSYWLWNR*KLWD
*SGLDGLYFRGSCSLGEDGKLPQYLD*SNTASQ
NAFDCQDFQMSPNSTGSSTENY*TGGI*S*KSE
*VDKYPHFLSIAPKEYYTACKSQSACASLITRPK
GFKYNKMCNL*L*Y*IRYLNKLGKLNFCCCFKE
KAAPEH*TWGIVKKQNVLVCHHVFHTTILCHS*
EGLVPLQDLCRLWEKVAERYSKWSREWRQTSVMI
KKKMDLKKLFTL*SLIKYGIPY*GNETETTGVF
LP*ENKQLKQASNVF*CHPLAIGTIQLLACFDL
ILK*VSSLYFYEFIFLKPCIYMIVFLITLLYESS
IRVVTNMFCNKVLIRM*VAQLYCSSYVCKIFVF
CKNP*NKLSFDLNCIRKLA*LLILNKIF*EF*T
SK

Sequence NM_206929

ACAGAAGAATAGAGAGGCTGTTGCAGCCCCGTGCTTTCTCCTGCTGCTGGCCGATTGCTTGCTCTGAACTAACCCTCTAACCCTTGGGAGTCTGTGTGCA
GCAGTGATGTGAGCTGCATCCGGGCTGAAATGGGAGCTCCCGCTATGGCACTGGCTCAAGGAGCTAATCTAAAGAGAAAATCAAGCAAAAGTAGATAATC
AGCCAGAAGAATTAGTGCGTAGTGCTGAAGATGATGAGAAACCAGATCAGAAGCCAGTTACAAATGAATGCGTACCAAGAATTTCCACAGTGCCTACACA
ACCTGATAATCCATTTTCTCACCCTGACAAACTCAAAAGGATGAGCAAGTCTGTTCCAGCATTTCTCCAAGATGAGAGTGATGACAGAGAAACAGATACA
GCATCAGAAAGCAGTTACCAGCTCAGCAGACACAAGAAGAGCCCGAGCTCTTTAACCAATCTTAGCAGCTCCTCTGGCATGACGTCCTTGTCTTCTGTGA
GTGGCAGTGTGATGAGTGTTTATAGTGGAGACTTTGGCAATCTGGAAGTTAAAGGAAATATTCAGTTTGCAATTGAATATGTGGAGTCACTGAAGGAGTT
GCATGTTTTTGTGGCCCAGTGTAAGGACTTAGCAGCAGCGGATGTAAAAAAACAGCGTTCAGACCCATATGTAAAGGCCTATTTGCTACCAGACAAAGGC
AAAATGGGCAAGAAGAAAACACTCGTAGTGAAGAAAACCTTGAATCCTGTGTATAACGAAATACTGCGGTATAAAATTGAAAAACAAATCTTAAAGACAC
AGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAA
ACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTAT
GTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATC
TAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCA
CACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGA
GGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAA
ACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAA
AACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTA
AAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAA
CAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGC
CATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACT
CAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGGAAT
TCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCACCCACTG
GCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTTTTAAAACCCTGCATAT
ATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCA
GTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAAACCCTTAGAATAAATTATCATTTGATTTAAATTGTATTAGAAAATTAGCGTGA
CTTCTCATTTTAAATAAAATATTTTAGGAATTCTAAACATCTAAA
  • refseq_SYTL2.F1 (forward primer)
  • refseq_SYTL2.R1 (reverse primer)
  • Single exon skipping

Frame 0

TEE*RGCCSPVLSPAAGRLLALN*PSNPWESVC
SSDVSCIRAEMGAPAMALAQGANLKRKSSKSR*S
ARRISA*C*R**ETRSEASYK*MRTKNFHSAYT
T**SIFSP*QTQKDEQVCSSISPR*E**QRNRY
SIRKQLPAQQTQEEPELFNQS*QLLWHDVLVFCE
WQCDECL*WRLWQSGS*RKYSVCN*ICGVTEGV
ACFCGPV*GLSSSGCKKTAFRPICKGLFATRQR
QNGQEENTRSEENLESCV*RNTAV*N*KTNLKDT
EIEPVHLASGYI*AQ*FPRGGGT*FGNMGLG*Q
TE*TIEMVPSEAEDSTSCP*SRKQR*NETSSPV
CPRASPW*KASYNWRSAHLGEGMP*STTAKGKSS
KFFC*MYHPSRYK*EKSPEDKSCRENHQPYLQP
HYGV*WVQA*RSDGSLCRAYCLGPLQINQPIFG
RSSYWLWNR*KLWD*SGLDGLYFRGSCSLGEDGK
LPQYLD*SNTASQNAFDCQDFQMSPNSTGSSTE
NY*TGGI*S*KSE*VDKYPHFLSIAPKEYYTAC
KSQSACASLITRPKGFKYNKMCNL*L*Y*IRYLN
KLGKLNFCCCFKEKAAPEH*TWGIVKKQNVLVC
HHVFHTTILCHS*EGLVPLQDLCRLWEKVAERY
SKWSREWRQTSVMIKKKMDLKKLFTL*SLIKYGI
PY*GNETETTGVFLP*ENKQLKQASNVF*CHPL
AIGTIQLLACFDLILK*VSSLYFYEFIFLKPCI
YMIVFLITLLYESSIRVVTNMFCNKVLIRM*VAQ
LYCSSYVCKIFVFCKNP*NKLSFDLNCIRKLA*
LLILNKIF*EF*TSK

Frame 1

QKNREAVAAPCFLLLLADCLL*TNPLTLGSLCA
AVM*AASGLKWELPLWHWLKELI*RENQAKVDN
QPEELVRSAEDDEKPDQKPVTNECVPRISTVPTQ
PDNPFSHPDKLKRMSKSVPAFLQDESDDRETDT
ASESSYQLSRHKKSPSSLTNLSSSSGMTSLSSV
SGSVMSVYSGDFGNLEVKGNIQFAIEYVESLKEL
HVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKG
KMGKKKTLVVKKTLNPVYNEILRYKIEKQILKT
QKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNK
QNKQLRWYPLKRKTAPVALEAENRGEMKLALQY
VPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSH
LNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNH
TMVYDGFRPEDLMEACVELTVWDHYKLTNQFLG
GLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMV
NSPNTWIEATLPLRMLLIAKISK*AQIPLAPPLK
TTKPVESDLENLSRWTNILTFYLLHLRNTTQHV
KVNLHVLL*LQGPRDLNITKCVICDSNIK*DI*
TS*EN*ISAAASKKKLPQSIKHGVLLRSKMFLFA
IMCFTPQFCATVKRVWYPCRTFVGCGKKSQKDT
QSGAGNGDRHQ***KKKWTLRNYLLCNL**NME
FHIRAMRLKLLVFFCLEKTNS*NKPQMYFSATHW
P*VQFSCWLVLT*F*NRSQACIFMSLFF*NPAY
I*LFFL*LYYMKAA*E*SQTCFATKF*LECKLL
SYTVLLMYVKFSYFVKTLRINYHLI*IVLEN*RD
FSF*IKYFRNSKHL

Frame 2

RRIERLLQPRAFSCCWPIACSELTL*PLGVCVQ
Q*CELHPG*NGSSRYGTGSRS*SKEKIKQK*II
SQKN*CVVLKMMRNQIRSQLQMNAYQEFPQCLH
NLIIHFLTLTNSKG*ASLFQHFSKMRVMTEKQIQ
HQKAVTSSADTRRARAL*PILAAPLA*RPCLL*
VAV**VFIVETLAIWKLKEIFSLQLNMWSH*RS
CMFLWPSVRT*QQRM*KNSVQTHM*RPICYQTKA
KWARRKHS**RKP*ILCITKYCGIKLKNKS*RH
RN*TCPFGIGIHLSAIVS*GRWNLIWKHGTGIT
NRINN*DGTL*SGRQHQLPLKQKTEVK*N*LSSM
SQSQSLVKSFLQLEKCTSG*RNALIYHC*GEVI
*ILLLNVPSFQIQVGKVARRQEL*GKPPTLSST
TLWCMMGSGLKI*WKPV*SLLSGTITN*PTNFWE
VFVLALEQVKVMGLKWTGWTLLQRKLLSGRRW*
TPPILGLKQHCLSECF*LPRFPNEPKFHWLLH*
KLLNRWNLILKI*VGGQISSLSIYCT*GILHSM*
KSICMCFFDYKAQGI*I*QNV*FVTLILNKIFE
QARKIEFLLLLQRKSCPRALNMGYC*EAKCSCL
PSCVSHHNSVPQLRGSGTLAGPL*VVGKSRRKIL
KVEQGMETDISDDKKKNGP*ETIYSVISNKIWN
SILGQ*D*NYWCFSALRKQTVKTSLKCILVPPT
GHRYNSVVGLF*LNSKIGLKPVFL*VYFFKTLHI
YDCFSYNFTI*KQHKSSHKHVLQQSFN*NVSCS
VILFFLCM*NFRIL*KPLE*III*FKLY*KISV
TSHFK*NILGILNI*

Sequence NM_206927

CTAAAAGAAAGAATGGATGAACCCAATGCAGAACAGGTCTATAATCCCTCTCAGTTTGAGAATTTGAGAAAGTTTTGGGACTTAGAAGCTAATTCAAACA
GTAAGGATAATGACAAGAATATTACCACCACAAGCCAAAAAAATTCTGCACCTTTTAATAGGCAGAAACACAAGGAATTCAGCGACATTAAATTATCAGG
TAAAAATACCCATGAAGCAGAGGTGCTTCTAAGCCCAAAAAAAGTTATGGCAAGAGAGGAAATGGAGAAATTAAATTCAAAGGGCATACTCCAGGTGCTA
CCAGATGAAATCACATTTCCTTTGAGTCCACTTAGAAAGTATACTTATCAGTTGCCAGGAAATGAGTCATCAAAGGAAAATGTGGAAAAGAATACGGAAG
GGATTGTTACTCCAGTGTTTAAGGAAGAAAAGGATTACTCAGAACAAGAGATTCAAGAATCCATAATAAAAACCAATGTTTTGTCTAAAGACTGCAAAGA
CACTTTTAATGACAGCTTGCAGAAACTGCTTTCAGAAACCTCAACACCAGCAATTCAACCCTCTGGTGGAAAAGTTCATGGAAAACAAGTGCTTGAACCA
AGTGTTTCTGAAAATAGGACATGGCCTCAAAAAACAGATTTTGCTGATACTGAGGAAGAAGTCAAAGGACCTGAGAAGATCATTAATGAGCATGTTGACA
AAACAGTAGTTCATCCAAAGGTTAAACGGAACTCTTTGACTGCTAGTCTAGACAAACTCCTGAAGGAAGCAACTGGAACTTCACCCTCTCCCTTGCAAGC
CAAGTTGGCGCCTGTTATCACTGGAACCAACTCTAAGCTGGAAGAGGGGAGATTTTTTGGAAAAGGGATAGAACAGAGTCACAATACTTCAGCTGATAAG
AGAGAAATACTAGCTCCTTTTCCAGTGAGAGATGAAACTTTTGGAAATACAGCTCTCCTCAAGAAAGCTGAAAGTGGTGAGTGCCAGCTAAGCACACAGA
ATTTGATTCAGATGGCTGCAGAAGATTCTCATCCATTGGATCCAACTTCCCAGCTTTCCAGAAAGGGTTCTTTTGGGGATGTGGCCAGCCCTCCCCAAGA
TATGCTTTTTCCCCAGGATGCTCATCTTGTTCCCCAGGCTAGGGTACACCCTTCTCAAACGGAAATTTCGGAGACTGTAGAGAAAGTCATTCTTCCACCC
AGACCTGTATTGAATGATGTAAGTGCTGCATTACAGAAGCTGTGTGGAGAAGTATGGTTAAGTTATCCAGCTGGAAGGGAAGTAGGTCCTGGAGAAGTGA
ACCCAGAATTTCCTGAAGCAGTACAGCCAGTATGTAGCCCCCTAAATCCTCCAGGAGTGATATCACCATGGGCTACGATGGACACCATAGTTCCAGACAG
GAAGGATTTTTATTCCTCCAATGTAGTTCCTGATAAAACTCATGAAGTTGGATCTTATTTAGCTGCCCAAATGTCTCCATCAGACCAGACGCTTAGCTCA
TTTGCTTCCATTGTTGCTCAATATGGCAAAGGCCTCCCTCAGGAAGTGGAAGAAATTGTGAGGGAAACAATTGTTCAACCCAAATCAGAGTTCCTCGAAT
TCAGTGCTGGCTTAGAAAAACTACTGAAGGAAGAAACTGAAACCTTCCCCTCAAAATATGAAAGTGATACAGGGAATCTTTCTCCATCAAAGTTAATAGG
TAGTACAGAGGAGCCCAGGCGAGCCACTTCTGAATGCCATCCTGAGGAATTAAAAGAAACAGTAGAAAAGGCCGAGGCTCCGTTAATAACTGAGAGTGCT
TTTGATGCTGGTTTTGAGAAACTTCTTAAAGAAATAACTGAAGCTCCTCCTTATCAGCCCCAGGTGTCAGTGAGAGAAGAAACTCACGAGAAGGAGTCCT
CACAGTCAGAGCAGACCAGGTTCTTGGGGACAGTGCCCCATTTTTACAGGGCAGCCTCACAGACCTCTGAAATGAAGGATAAAAGTAATGGTTTGGAATC
TCAAGTCAACCAATGTGATAAAATGTTGGGAGGAGACGCACTTGTGACTGATTTATTGGTAGATTTTTGTGGTTCCAGAAGTGGAGTTGAGATCCCTAGA
ACCCCACAACTTTATGTGGCTCATGAAATAGGGACCATTAAAACTGTAACCCCCCCAGAGGACAGGGACAGTGAAAGTGGGGTTGCAGGGGGACAAGGGA
CTCTTCAGGAACCTGGCTTTGGAGAGGCTTCTGAAGCAATTAGTGTGTCCAGAAATAGGCAACCCATTCCTCTCCTGATGAACAAAGAAAACTCTACAAA
AACAAGTAAAGTTGAATTGACTCTAGCATCGCCATATATGAAACAAGAGAAAGAGGAAGAAAAAGAAGGTTTCTCTGAGTCTGATTTTTCAGATGGAAAC
ACCAGTTCTAATGCAGAGAGCTGGAGAAATCCTTCCAGTTCAGAAGAAGAACCCAGTCCTGTTTTGAAAACTTTGGAAAGGAGTGCCGCTAGGAAAATGC
CTTCCAAAAGTCTAGAAGACATTTCATCAGATTCATCAAATCAAGCAAAAGTAGATAATCAGCCAGAAGAATTAGTGCGTAGTGCTGAAGATGATGAGAA
ACCAGATCAGAAGCCAGTTACAAATGAATGCGTACCAAGAATTTCCACAGTGCCTACACAACCTGATAATCCATTTTCTCACCCTGACAAACTCAAAAGG
ATGAGCAAGTCTGTTCCAGCATTTCTCCAAGATGAGAGTGATGACAGAGAAACAGATACAGCATCAGAAAGCAGTTACCAGCTCAGCAGACACAAGAAGA
GCCCGAGCTCTTTAACCAATCTTAGCAGCTCCTCTGGCATGACGTCCTTGTCTTCTGTGAGTGGCAGTGTGATGAGTGTTTATAGTGGAGACTTTGGCAA
TCTGGAAGTTAAAGGAAATATTCAGTTTGCAATTGAATATGTGGAGTCACTGAAGGAGTTGCATGTTTTTGTGGCCCAGTGTAAGGACTTAGCAGCAGCG
GATGTAAAAAAACAGCGTTCAGACCCATATGTAAAGGCCTATTTGCTACCAGACAAAGGCAAAATGGGCAAGAAGAAAACACTCGTAGTGAAGAAAACCT
TGAATCCTGTGTATAACGAAATACTGCGGTATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAA
GCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAG
ACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTG
GAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAG
TAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATG
GAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGA
CTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAG
AATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGT
AGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAA
GGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAA
AAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAG
AGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGAT
AAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTT
CTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAA
TTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAG
CATAAGAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTT
TGTAAAAACCCTTAGAATAAATTATCATTTGATTTAAATTGTATTAGAAAATTAGCGTGACTTCTCATTTTAAATAAAATATTTTAGGAATTCTAAACAT
CTAAA
  • refseq_SYTL2.F1 (forward primer)
  • refseq_SYTL2.R1 (reverse primer)
  • Single exon skipping

Frame 0

LKERMDEPNAEQVYNPSQFENLRKFWDLEANSN
SKDNDKNITTTSQKNSAPFNRQKHKEFSDIKLSG
KNTHEAEVLLSPKKVMAREEMEKLNSKGILQVL
PDEITFPLSPLRKYTYQLPGNESSKENVEKNTE
GIVTPVFKEEKDYSEQEIQESIIKTNVLSKDCKD
TFNDSLQKLLSETSTPAIQPSGGKVHGKQVLEP
SVSENRTWPQKTDFADTEEEVKGPEKIINEHVD
KTVVHPKVKRNSLTASLDKLLKEATGTSPSPLQA
KLAPVITGTNSKLEEGRFFGKGIEQSHNTSADK
REILAPFPVRDETFGNTALLKKAESGECQLSTQ
NLIQMAAEDSHPLDPTSQLSRKGSFGDVASPPQD
MLFPQDAHLVPQARVHPSQTEISETVEKVILPP
RPVLNDVSAALQKLCGEVWLSYPAGREVGPGEV
NPEFPEAVQPVCSPLNPPGVISPWATMDTIVPDR
KDFYSSNVVPDKTHEVGSYLAAQMSPSDQTLSS
FASIVAQYGKGLPQEVEEIVRETIVQPKSEFLE
FSAGLEKLLKEETETFPSKYESDTGNLSPSKLIG
STEEPRRATSECHPEELKETVEKAEAPLITESA
FDAGFEKLLKEITEAPPYQPQVSVREETHEKES
SQSEQTRFLGTVPHFYRAASQTSEMKDKSNGLES
QVNQCDKMLGGDALVTDLLVDFCGSRSGVEIPR
TPQLYVAHEIGTIKTVTPPEDRDSESGVAGGQG
TLQEPGFGEASEAISVSRNRQPIPLLMNKENSTK
TSKVELTLASPYMKQEKEEEKEGFSESDFSDGN
TSSNAESWRNPSSSEEEPSPVLKTLERSAARKM
PSKSLEDISSDSSNQAKVDNQPEELVRSAEDDEK
PDQKPVTNECVPRISTVPTQPDNPFSHPDKLKR
MSKSVPAFLQDESDDRETDTASESSYQLSRHKK
SPSSLTNLSSSSGMTSLSSVSGSVMSVYSGDFGN
LEVKGNIQFAIEYVESLKELHVFVAQCKDLAAA
DVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKT
LNPVYNEILRYKIEKQILKTQKLNLSIWHRDTFK
RNSFLGEVELDLETWDWDNKQNKQLRWYPLKRK
TAPVALEAENRGEMKLALQYVPEPVPGKKLPTT
GEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTS
RKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLM
EACVELTVWDHYKLTNQFLGGLRIGFGTGKSYG
TEVDWMDSTSEEVALWEKMVNSPNTWIEATLPLR
MLLIAKISK*AQIPLAPPLKTTKPVESDLENLS
RWTNILTFYLLHLRNTTQHVKVNLHVLL*LQGP
RDLNITKCVICDSNIK*DI*TS*EN*ISAAASKK
KLPQSIKHGVLLRSKMFLFAIMCFTPQFCATVK
RVWYPCRTFVGCGKKSQKDTQSGAGNGDRHQ**
*KKKWTLRNYLLCNL**NMEFHIRAMRLKLLVFF
CLEKTNS*NKPQMYFSATHWP*VQFSCWLVLT*
F*NRSQACIFMSLFF*NPAYI*LFFL*LYYMKA
A*E*SQTCFATKF*LECKLLSYTVLLMYVKFSYF
VKTLRINYHLI*IVLEN*RDFSF*IKYFRNSKH
L

Frame 1

*KKEWMNPMQNRSIIPLSLRI*ESFGT*KLIQT
VRIMTRILPPQAKKILHLLIGRNTRNSATLNYQ
VKIPMKQRCF*AQKKLWQERKWRN*IQRAYSRCY
QMKSHFL*VHLESILISCQEMSHQRKMWKRIRK
GLLLQCLRKKRITQNKRFKNP**KPMFCLKTAK
TLLMTACRNCFQKPQHQQFNPLVEKFMENKCLNQ
VFLKIGHGLKKQILLILRKKSKDLRRSLMSMLT
KQ*FIQRLNGTL*LLV*TNS*RKQLELHPLPCK
PSWRLLSLEPTLSWKRGDFLEKG*NRVTILQLIR
EKY*LLFQ*EMKLLEIQLSSRKLKVVSAS*AHR
I*FRWLQKILIHWIQLPSFPERVLLGMWPALPK
ICFFPRMLILFPRLGYTLLKRKFRRL*RKSFFHP
DLY*MM*VLHYRSCVEKYG*VIQLEGK*VLEK*
TQNFLKQYSQYVAP*ILQE*YHHGLRWTP*FQT
GRIFIPPM*FLIKLMKLDLI*LPKCLHQTRRLAH
LLPLLLNMAKASLRKWKKL*GKQLFNPNQSSSN
SVLA*KNY*RKKLKPSPQNMKVIQGIFLHQS**
VVQRSPGEPLLNAILRN*KKQ*KRPRLR**LRVL
LMLVLRNFLKK*LKLLLISPRCQ*EKKLTRRSP
HSQSRPGSWGQCPIFTGQPHRPLK*RIKVMVWN
LKSTNVIKCWEETHL*LIYW*IFVVPEVELRSLE
PHNFMWLMK*GPLKL*PPQRTGTVKVGLQGDKG
LFRNLALERLLKQLVCPEIGNPFLS**TKKTLQ
KQVKLN*L*HRHI*NKRKRKKKKVSLSLIFQMET
PVLMQRAGEILPVQKKNPVLF*KLWKGVPLGKC
LPKV*KTFHQIHQIKQK*IISQKN*CVVLKMMR
NQIRSQLQMNAYQEFPQCLHNLIIHFLTLTNSKG
*ASLFQHFSKMRVMTEKQIQHQKAVTSSADTRR
ARAL*PILAAPLA*RPCLL*VAV**VFIVETLA
IWKLKEIFSLQLNMWSH*RSCMFLWPSVRT*QQR
M*KNSVQTHM*RPICYQTKAKWARRKHS**RKP
*ILCITKYCGIKLKNKS*RHRN*TCPFGIGIHL
SAIVS*GRWNLIWKHGTGITNRINN*DGTL*SGR
QHQLPLKQKTEVK*N*LSSMSQSQSLVKSFLQL
EKCTSG*RNALIYHC*GEVI*ILLLNVPSFQIQ
VGKVARRQEL*GKPPTLSSTTLWCMMGSGLKI*W
KPV*SLLSGTITN*PTNFWEVFVLALEQVKVMG
LKWTGWTLLQRKLLSGRRW*TPPILGLKQHCLS
ECF*LPRFPNEPKFHWLLH*KLLNRWNLILKI*V
GGQISSLSIYCT*GILHSM*KSICMCFFDYKAQ
GI*I*QNV*FVTLILNKIFEQARKIEFLLLLQR
KSCPRALNMGYC*EAKCSCLPSCVSHHNSVPQLR
GSGTLAGPL*VVGKSRRKILKVEQGMETDISDD
KKKNGP*ETIYSVISNKIWNSILGQ*D*NYWCF
SALRKQTVKTSLKCILVPPTGHRYNSVVGLF*LN
SKIGLKPVFL*VYFFKTLHIYDCFSYNFTI*KQ
HKSSHKHVLQQSFN*NVSCSVILFFLCM*NFRI
L*KPLE*III*FKLY*KISVTSHFK*NILGILNI
*

Frame 2

KRKNG*TQCRTGL*SLSV*EFEKVLGLRS*FKQ
*G**QEYYHHKPKKFCTF**AETQGIQRH*IIR
*KYP*SRGASKPKKSYGKRGNGEIKFKGHTPGA
TR*NHISFEST*KVYLSVARK*VIKGKCGKEYGR
DCYSSV*GRKGLLRTRDSRIHNKNQCFV*RLQR
HF**QLAETAFRNLNTSNSTLWWKSSWKTSA*T
KCF*K*DMASKNRFC*Y*GRSQRT*EDH**AC*Q
NSSSSKG*TELFDC*SRQTPEGSNWNFTLSLAS
QVGACYHWNQL*AGRGEIFWKRDRTESQYFS**
ERNTSSFSSER*NFWKYSSPQES*KW*VPAKHTE
FDSDGCRRFSSIGSNFPAFQKGFFWGCGQPSPR
YAFSPGCSSCSPG*GTPFSNGNFGDCRESHSST
QTCIE*CKCCITEAVWRSMVKLSSWKGSRSWRSE
PRIS*SSTASM*PPKSSRSDITMGYDGHHSSRQ
EGFLFLQCSS**NS*SWILFSCPNVSIRPDA*L
ICFHCCSIWQRPPSGSGRNCEGNNCSTQIRVPRI
QCWLRKTTEGRN*NLPLKI*K*YRESFSIKVNR
*YRGAQASHF*MPS*GIKRNSRKGRGSVNN*EC
F*CWF*ETS*RNN*SSSLSAPGVSERRNSREGVL
TVRADQVLGDSAPFLQGSLTDL*NEG*K*WFGI
SSQPM**NVGRRRTCD*FIGRFLWFQKWS*DP*
NPTTLCGS*NRDH*NCNPPRGQGQ*KWGCRGTRD
SSGTWLWRGF*SN*CVQK*ATHSSPDEQRKLYK
NK*S*IDSSIAIYETRERGRKRRFL*V*FFRWK
HQF*CRELEKSFQFRRRTQSCFENFGKECR*ENA
FQKSRRHFIRFIKSSKSR*SARRISA*C*R**E
TRSEASYK*MRTKNFHSAYTT**SIFSP*QTQK
DEQVCSSISPR*E**QRNRYSIRKQLPAQQTQEE
PELFNQS*QLLWHDVLVFCEWQCDECL*WRLWQ
SGS*RKYSVCN*ICGVTEGVACFCGPV*GLSSS
GCKKTAFRPICKGLFATRQRQNGQEENTRSEENL
ESCV*RNTAV*N*KTNLKDTEIEPVHLASGYI*
AQ*FPRGGGT*FGNMGLG*QTE*TIEMVPSEAE
DSTSCP*SRKQR*NETSSPVCPRASPW*KASYNW
RSAHLGEGMP*STTAKGKSSKFFC*MYHPSRYK
*EKSPEDKSCRENHQPYLQPHYGV*WVQA*RSD
GSLCRAYCLGPLQINQPIFGRSSYWLWNR*KLWD
*SGLDGLYFRGSCSLGEDGKLPQYLD*SNTASQ
NAFDCQDFQMSPNSTGSSTENY*TGGI*S*KSE
*VDKYPHFLSIAPKEYYTACKSQSACASLITRPK
GFKYNKMCNL*L*Y*IRYLNKLGKLNFCCCFKE
KAAPEH*TWGIVKKQNVLVCHHVFHTTILCHS*
EGLVPLQDLCRLWEKVAERYSKWSREWRQTSVMI
KKKMDLKKLFTL*SLIKYGIPY*GNETETTGVF
LP*ENKQLKQASNVF*CHPLAIGTIQLLACFDL
ILK*VSSLYFYEFIFLKPCIYMIVFLITLLYESS
IRVVTNMFCNKVLIRM*VAQLYCSSYVCKIFVF
CKNP*NKLSFDLNCIRKLA*LLILNKIF*EF*T
SK

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