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Sequences

Sequence NM_170675

TCCCGCTCCCCACTCCCGGGATGTGTCTCCGCCGTACGACGGGCTATGGCCACCACGACTTCCGGGTTCCGTCATTTCGTTCTCCCGCCGCCGACCCGCG
CCGCCAAACTGAGGCTCTTCAATAAGCCAGGCAGCAGCCAACCTGCCAACACCTACTGACACTCACTCATCTCCCAGAGAGAGAAAGAGAGCGAGAGAGA
GCGAGCGCGAGAGAGCGAGCGCGAGTGAGAGCGAGCGAGCGAGCGAGAAAGAGAGAGAGGGAGAGACAAAATACCTACCAGGAAAGGGGGGGAGGAAGTC
CAATTTTTGCAAACTATTCATTTTTTTTTCTTGATTTTTCTCACTGCTTTCTTTGAACAATACTTTAAAGAGAGAGGATCGTATTATAGATACCGCGGGG
GCAAAGCTAAAAAAGGGGGGAGGGGGGAGGAAAAAATTCAAGAAGCAGAAACCCCTCGCGGAGTTTTACTGGAAGAAAAAAACGGGTCTGAAAGATTCCT
CCTCTTCATCATCATCAACCATCATTCATTCACTACCTTGACATTCCGGGCTTTGATTGACAGCTGGAGTGGCAAAAAGCCATGAAACACGACAGTTCGG
TTACATGTGGGCTGCTGACGGGCCGCTCGTAACCTTCAGTTCGGGGGCTTGACAATTTTTTTCTTCTTTTTCTTCTTTTTCTTTTCTTTCTTTTTTTTTC
CAACTGAGGGGAAGAGAAGAGAAAGAGGGGGAAAGGAGGACCGAAGAGGAGGAGGAGGGGAGGGGGGAGGAGGAGGAGGTGGAGGAGGAGGAGGAAGATC
AGGAGGAGGAGGAAGAAGAGGAAAAAAGAGAAAAAGAAGAAATATCACAGAAAAAAAAATTCTTCGTTGTCTAGACTGGGCTTTTTTTCCCCCCTAAAAA
ATAGCATATTGGAGAATTGGGAGAAGTCTCTTTGGTTTGGAAAAAAAAAAAAGGAATCTTCAGCCTAGATCACTTTCTTATCCGGACTGGGATATTAAAT
ATACGACACATCCAGGAGTTTATTGGAGCGCAGACTGATGGCGCAAAGGTACGATGAGCTGCCCCATTACGGCGGGATGGACGGAGTAGGGGTTCCCGCT
TCCATGTACGGAGACCCTCACGCGCCGCGGCCGATCCCCCCGGTTCACCACCTGAACCACGGGCCGCCGCTCCACGCCACACAGCACTACGGCGCGCACG
CCCCGCACCCCAATGTCATGCCGGCCAGTATGGGATCCGCTGTCAACGACGCCTTGAAGCGGGACAAGGACGCGATCTATGGGCACCCGTTGTTTCCTCT
GTTAGCTCTGGTCTTTGAGAAGTGCGAGCTGGCGACCTGCACTCCCCGGGAACCTGGAGTGGCTGGCGGAGACGTCTGCTCCTCCGACTCCTTCAACGAG
GACATCGCGGTCTTCGCCAAGCAGGTTCGCGCCGAAAAGCCACTTTTTTCCTCAAATCCAGAGCTGGACAATTTGATGATACAAGCAATACAAGTACTAA
GGTTTCATCTTTTGGAGTTAGAAAAGGTCCACGAACTGTGCGATAACTTCTGCCACCGATACATTAGCTGTTTGAAGGGGAAAATGCCCATCGACCTCGT
CATTGATGAAAGAGACGGCAGCTCCAAGTCAGATCATGAAGAACTTTCAGGCTCCTCCACAAATCTCGCTGACCATAACCCTTCTTCTTGGCGAGACCAC
GATGATGCAACCTCAACCCACTCAGCAGGCACCCCAGGGCCCTCCAGTGGGGGCCATGCTTCCCAGAGCGGAGACAACAGCAGTGAGCAAGGGGATGGTT
TAGACAACAGTGTAGCTTCACCTGGTACAGGTGACGATGATGATCCGGATAAGGACAAAAAACGCCAGAAGAAAAGAGGCATTTTCCCCAAAGTAGCAAC
AAATATCATGAGAGCATGGCTCTTCCAGCATCTCACACATCCGTACCCTTCCGAAGAGCAGAAGAAACAGTTAGCGCAAGACACAGGACTTACAATTCTC
CAAGTAAACAACTGGTTTATTAATGCCAGAAGAAGAATAGTACAGCCCATGATTGACCAGTCAAATCGAGCAGGTTTTCTTCTTGATCCTTCAGTGAGCC
AAGGAGCAGCATATAGTCCAGAGGGTCAGCCCATGGGGAGCTTTGTGTTGGATGGTCAGCAACACATGGGGATCCGGCCTGCAGGTTTGCAGAGCATGCC
AGGGGACTACGTTTCTCAGGGTGGTCCTATGGGAATGAGTATGGCACAGCCAAGTTACACTCCTCCCCAGATGACCCCACACCCTACTCAATTAAGACAT
GGACCCCCAATGCATTCATATTTGCCAAGCCATCCCCACCACCCAGCCATGATGATGCACGGAGGACCCCCTACCCACCCTGGAATGACTATGTCAGCAC
AGAGCCCCACAATGTTAAATTCTGTAGATCCCAATGTTGGCGGACAGGTTATGGACATTCATGCCCAATAGTATAAGGGAACTCAAGGGAAAAGGAAACA
CACGCAAAAACTATTTTAAGACTTTCTGAACTTTGACCAGATGTTGACACTTAATATGAAATTCCAGACAGCTGTGATTATTTTTTACTTTTGTCATTTT
TCATCAAGCAACAGAGGACCAATGCAACAAGAACACAAATGTGAAATCATGGGCTGACTGAGACAATTCTGTCCATGTAAAGATCCTCTGGAAAAAGACT
CCGAGAGTTATAACTACTGTAGTATAAATATAGGAACTAAGTTAAACTTGTACATTTCTGTTGATCACGCCGTTATGTTGCCTCAAATAGTTTTAGAAGA
GAAAAAAAAATATATCCTTGTTTTCCACACTATGTGTGTTGTTCCCAAAAGAATGACTGTTTTGGTTCATCAGTGAATTCACCATCCAGGAGAGACTGTG
GTATATATTTTAAACCTGTTGGGCCAATGAGAAAAGAACCACACTGGAGATCATGATGAACTTTTGGCTGAACCTCATCACTCGAACTCCAGCTTCAAGA
ATGTGTTTTCATGCCCGGCCTTTGTTCCTCCATAAATGTGTCCTTTAGTTTCAAACAGATCTTTATAGTTCGTGCTTCATAAGCCAATTCTTATTATTAT
TTTTGGGGGACTCTTCTTCAAAGAGCTTGCCAATGAAGATTTAAAGACAGAGCAGGAGCTTCTTCCAGGAGTTCTGAGCCTTGGTTGTGGACAAAACAAT
CTTAAGTTGGGCAGCTTTCCTCAACACAAAAAAAAGTTATTAATGGTCATTGAACCATAACTAGGACTTTATCAGAAACTCAAAGCTTGGGGGATAAAAA
GGAGCAAGAGAATACTGTAACAAACTTCGTACAGAGTTCGGTCTATTAATTGTTTCATGTTAGATATTCTATGTGTTTACCTCAATTGAAAAAAAAAAGA
ATGTTTTTGCTAGTATCAGATCTGCTGTGGAATTGGTATTGTATGTCCATGAATTCTTCTTTTCTCAGCACGTGTTCCTCACTAGAAGAAAATGCTGTTA
CCTTTAAGCTTTGTCAAATTTACATTAAAATACTTGTATGAGGACTGTGACGTTATGTTAAAAAAAAAAAGGTGTTAAGTCACAAAAAGCGGTAATAAAT
ATTTCATTTTTGA
  • refseq_MEIS2.F4 (forward primer)
  • refseq_MEIS2.R4 (reverse primer)
  • Single exon skipping

Frame 0

SRSPLPGCVSAVRRAMATTTSGFRHFVLPPPTR
AAKLRLFNKPGSSQPANTY*HSLISQREKESERE
RARESERE*ERASERERERGRDKIPTRKGGEEV
QFLQTIHFFFLIFLTAFFEQYFKERGSYYRYRG
GKAKKGGRGEEKIQEAETPRGVLLEEKNGSERFL
LFIIINHHSFTTLTFRALIDSWSGKKP*NTTVR
LHVGC*RAARNLQFGGLTIFFFFFFFFFSFFFF
PTEGKRRERGGKEDRRGGGGEGGGGGGGGGGGRS
GGGGRRGKKRKRRNITEKKILRCLDWAFFPP*K
IAYWRIGRSLFGLEKKKRNLQPRSLSYPDWDIK
YTTHPGVYWSAD*WRKGTMSCPITAGWTE*GFPL
PCTETLTRRGRSPRFTT*TTGRRSTPHSTTART
PRTPMSCRPVWDPLSTTP*SGTRTRSMGTRCFL
C*LWSLRSASWRPALPGNLEWLAETSAPPTPSTR
TSRSSPSRFAPKSHFFPQIQSWTI**YKQYKY*
GFIFWS*KRSTNCAITSATDTLAV*RGKCPSTS
SLMKETAAPSQIMKNFQAPPQISLTITLLLGETT
MMQPQPTQQAPQGPPVGAMLPRAETTAVSKGMV
*TTV*LHLVQVTMMIRIRTKNARRKEAFSPK*Q
QIS*EHGSSSISHIRTLPKSRRNS*RKTQDLQFS
K*TTGLLMPEEE*YSP*LTSQIEQVFFLILQ*A
KEQHIVQRVSPWGALCWMVSNTWGSGLQVCRAC
QGTTFLRVVLWE*VWHSQVTLLPR*PHTLLN*DM
DPQCIHICQAIPTTQP**CTEDPLPTLE*LCQH
RAPQC*IL*IPMLADRLWTFMPNSIRELKGKGN
TRKNYFKTF*TLTRC*HLI*NSRQL*LFFTFVIF
HQATEDQCNKNTNVKSWAD*DNSVHVKILWKKT
PRVITTVV*I*ELS*TCTFLLITPLCCLK*F*K
RKKNISLFSTLCVLFPKE*LFWFISEFTIQERLW
YIF*TCWANEKRTTLEIMMNFWLNLITRTPASR
MCFHARPLFLHKCVL*FQTDLYSSCFISQFLLL
FLGDSSSKSLPMKI*RQSRSFFQEF*ALVVDKTI
LSWAAFLNTKKSY*WSLNHN*DFIRNSKLGG*K
GAREYCNKLRTEFGLLIVSC*IFYVFTSIEKKK
NVFASIRSAVELVLYVHEFFFSQHVFLTRRKCCY
L*ALSNLH*NTCMRTVTLC*KKKGVKSQKAVIN
ISFL

Frame 1

PAPHSRDVSPPYDGLWPPRLPGSVISFSRRRPA
PPN*GSSISQAAANLPTPTDTHSSPRERKRARE
SERERASASESERASEKEREGETKYLPGKGGRKS
NFCKLFIFFS*FFSLLSLNNTLKREDRIIDTAG
AKLKKGGGGRKKFKKQKPLAEFYWKKKTGLKDS
SSSSSSTIIHSLP*HSGL*LTAGVAKSHETRQFG
YMWAADGPLVTFSSGA*QFFSSFSSFSFLSFFF
QLRGREEKEGERRTEEEEEGRGEEEEVEEEEED
QEEEEEEEKREKEEISQKKKFFVV*TGLFFPPKK
*HIGELGEVSLVWKKKKGIFSLDHFLIRTGILN
IRHIQEFIGAQTDGAKVR*AAPLRRDGRSRGSR
FHVRRPSRAAADPPGSPPEPRAAAPRHTALRRAR
PAPQCHAGQYGIRCQRRLEAGQGRDLWAPVVSS
VSSGL*EVRAGDLHSPGTWSGWRRRLLLRLLQR
GHRGLRQAGSRRKATFFLKSRAGQFDDTSNTSTK
VSSFGVRKGPRTVR*LLPPIH*LFEGENAHRPR
H**KRRQLQVRS*RTFRLLHKSR*P*PFFLARP
R*CNLNPLSRHPRALQWGPCFPERRQQQ*ARGWF
RQQCSFTWYR*R**SG*GQKTPEEKRHFPQSSN
KYHESMALPASHTSVPFRRAEETVSARHRTYNS
PSKQLVY*CQKKNSTAHD*PVKSSRFSS*SFSEP
RSSI*SRGSAHGELCVGWSATHGDPACRFAEHA
RGLRFSGWSYGNEYGTAKLHSSPDDPTPYSIKT
WTPNAFIFAKPSPPPSHDDARRTPYPPWNDYVST
EPHNVKFCRSQCWRTGYGHSCPIV*GNSREKET
HAKTILRLSEL*PDVDT*YEIPDSCDYFLLLSF
FIKQQRTNATRTQM*NHGLTETILSM*RSSGKRL
REL*LL*YKYRN*VKLVHFC*SRRYVASNSFRR
EKKIYPCFPHYVCCSQKNDCFGSSVNSPSRRDC
GIYFKPVGPMRKEPHWRS**TFG*TSSLELQLQE
CVFMPGLCSSINVSFSFKQIFIVRAS*ANSYYY
FWGTLLQRACQ*RFKDRAGASSRSSEPWLWTKQ
S*VGQLSSTQKKVINGH*TITRTLSETQSLGDKK
EQENTVTNFVQSSVY*LFHVRYSMCLPQLKKKR
MFLLVSDLLWNWYCMSMNSSFLSTCSSLEENAV
TFKLCQIYIKILV*GL*RYVKKKKVLSHKKR**I
FHF*

Frame 2

PLPTPGMCLRRTTGYGHHDFRVPSFRSPAADPR
RQTEALQ*ARQQPTCQHLLTLTHLPERERERER
ASARERARVRASERARKRERERQNTYQERGGGS
PIFANYSFFFLDFSHCFL*TIL*RERIVL*IPRG
QS*KRGEGGGKNSRSRNPSRSFTGRKKRV*KIP
PLHHHQPSFIHYLDIPGFD*QLEWQKAMKHDSS
VTCGLLTGRS*PSVRGLDNFFLLFLLFLFFLFFS
N*GEEKRKRGKGGPKRRRRGGGRRRRWRRRRKI
RRRRKKRKKEKKKKYHRKKNSSLSRLGFFSPLK
NSILENWEKSLWFGKKKKESSA*ITFLSGLGY*I
YDTSRSLLERRLMAQRYDELPHYGGMDGVGVPA
SMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAH
APHPNVMPASMGSAVNDALKRDKDAIYGHPLFPL
LALVFEKCELATCTPREPGVAGGDVCSSDSFNE
DIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVL
RFHLLELEKVHELCDNFCHRYISCLKGKMPIDLV
IDERDGSSKSDHEELSGSSTNLADHNPSSWRDH
DDATSTHSAGTPGPSSGGHASQSGDNSSEQGDG
LDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVAT
NIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTIL
QVNNWFINARRRIVQPMIDQSNRAGFLLDPSVS
QGAAYSPEGQPMGSFVLDGQQHMGIRPAGLQSMP
GDYVSQGGPMGMSMAQPSYTPPQMTPHPTQLRH
GPPMHSYLPSHPHHPAMMMHGGPPTHPGMTMSA
QSPTMLNSVDPNVGGQVMDIHAQ*YKGTQGKRKH
TQKLF*DFLNFDQMLTLNMKFQTAVIIFYFCHF
SSSNRGPMQQEHKCEIMG*LRQFCPCKDPLEKD
SESYNYCSINIGTKLNLYISVDHAVMLPQIVLEE
KKKYILVFHTMCVVPKRMTVLVHQ*IHHPGETV
VYILNLLGQ*EKNHTGDHDELLAEPHHSNSSFK
NVFSCPAFVPP*MCPLVSNRSL*FVLHKPILIII
FGGLFFKELANEDLKTEQELLPGVLSLGCGQNN
LKLGSFPQHKKKLLMVIEP*LGLYQKLKAWGIK
RSKRIL*QTSYRVRSINCFMLDILCVYLN*KKKE
CFC*YQICCGIGIVCP*ILLFSARVPH*KKMLL
PLSFVKFTLKYLYEDCDVMLKKKRC*VTKSGNK
YFIF

Sequence NM_170676

TCCCGCTCCCCACTCCCGGGATGTGTCTCCGCCGTACGACGGGCTATGGCCACCACGACTTCCGGGTTCCGTCATTTCGTTCTCCCGCCGCCGACCCGCG
CCGCCAAACTGAGGCTCTTCAATAAGCCAGGCAGCAGCCAACCTGCCAACACCTACTGACACTCACTCATCTCCCAGAGAGAGAAAGAGAGCGAGAGAGA
GCGAGCGCGAGAGAGCGAGCGCGAGTGAGAGCGAGCGAGCGAGCGAGAAAGAGAGAGAGGGAGAGACAAAATACCTACCAGGAAAGGGGGGGAGGAAGTC
CAATTTTTGCAAACTATTCATTTTTTTTTCTTGATTTTTCTCACTGCTTTCTTTGAACAATACTTTAAAGAGAGAGGATCGTATTATAGATACCGCGGGG
GCAAAGCTAAAAAAGGGGGGAGGGGGGAGGAAAAAATTCAAGAAGCAGAAACCCCTCGCGGAGTTTTACTGGAAGAAAAAAACGGGTCTGAAAGATTCCT
CCTCTTCATCATCATCAACCATCATTCATTCACTACCTTGACATTCCGGGCTTTGATTGACAGCTGGAGTGGCAAAAAGCCATGAAACACGACAGTTCGG
TTACATGTGGGCTGCTGACGGGCCGCTCGTAACCTTCAGTTCGGGGGCTTGACAATTTTTTTCTTCTTTTTCTTCTTTTTCTTTTCTTTCTTTTTTTTTC
CAACTGAGGGGAAGAGAAGAGAAAGAGGGGGAAAGGAGGACCGAAGAGGAGGAGGAGGGGAGGGGGGAGGAGGAGGAGGTGGAGGAGGAGGAGGAAGATC
AGGAGGAGGAGGAAGAAGAGGAAAAAAGAGAAAAAGAAGAAATATCACAGAAAAAAAAATTCTTCGTTGTCTAGACTGGGCTTTTTTTCCCCCCTAAAAA
ATAGCATATTGGAGAATTGGGAGAAGTCTCTTTGGTTTGGAAAAAAAAAAAAGGAATCTTCAGCCTAGATCACTTTCTTATCCGGACTGGGATATTAAAT
ATACGACACATCCAGGAGTTTATTGGAGCGCAGACTGATGGCGCAAAGGTACGATGAGCTGCCCCATTACGGCGGGATGGACGGAGTAGGGGTTCCCGCT
TCCATGTACGGAGACCCTCACGCGCCGCGGCCGATCCCCCCGGTTCACCACCTGAACCACGGGCCGCCGCTCCACGCCACACAGCACTACGGCGCGCACG
CCCCGCACCCCAATGTCATGCCGGCCAGTATGGGATCCGCTGTCAACGACGCCTTGAAGCGGGACAAGGACGCGATCTATGGGCACCCGTTGTTTCCTCT
GTTAGCTCTGGTCTTTGAGAAGTGCGAGCTGGCGACCTGCACTCCCCGGGAACCTGGAGTGGCTGGCGGAGACGTCTGCTCCTCCGACTCCTTCAACGAG
GACATCGCGGTCTTCGCCAAGCAGGTTCGCGCCGAAAAGCCACTTTTTTCCTCAAATCCAGAGCTGGACAATTTGATGATACAAGCAATACAAGTACTAA
GGTTTCATCTTTTGGAGTTAGAAAAGGTCCACGAACTGTGCGATAACTTCTGCCACCGATACATTAGCTGTTTGAAGGGGAAAATGCCCATCGACCTCGT
CATTGATGAAAGAGACGGCAGCTCCAAGTCAGATCATGAAGAACTTTCAGGCTCCTCCACAAATCTCGCTGACCATAACCCTTCTTCTTGGCGAGACCAC
GATGATGCAACCTCAACCCACTCAGCAGGCACCCCAGGGCCCTCCAGTGGGGGCCATGCTTCCCAGAGCGGAGACAACAGCAGTGAGCAAGGGGATGGTT
TAGACAACAGTGTAGCTTCACCTGGTACAGGTGACGATGATGATCCGGATAAGGACAAAAAACGCCAGAAGAAAAGAGGCATTTTCCCCAAAGTAGCAAC
AAATATCATGAGAGCATGGCTCTTCCAGCATCTCACACATCCGTACCCTTCCGAAGAGCAGAAGAAACAGTTAGCGCAAGACACAGGACTTACAATTCTC
CAAGTAAACAACTGGTTTATTAATGCCAGAAGAAGAATAGTACAGCCCATGATTGACCAGTCAAATCGAGCAGTGAGCCAAGGAGCAGCATATAGTCCAG
AGGGTCAGCCCATGGGGAGCTTTGTGTTGGATGGTCAGCAACACATGGGGATCCGGCCTGCAGGTTTGCAGAGCATGCCAGGGGACTACGTTTCTCAGGG
TGGTCCTATGGGAATGAGTATGGCACAGCCAAGTTACACTCCTCCCCAGATGACCCCACACCCTACTCAATTAAGACATGGACCCCCAATGCATTCATAT
TTGCCAAGCCATCCCCACCACCCAGCCATGATGATGCACGGAGGACCCCCTACCCACCCTGGAATGACTATGTCAGCACAGAGCCCCACAATGTTAAATT
CTGTAGATCCCAATGTTGGCGGACAGGTTATGGACATTCATGCCCAATAGTATAAGGGAACTCAAGGGAAAAGGAAACACACGCAAAAACTATTTTAAGA
CTTTCTGAACTTTGACCAGATGTTGACACTTAATATGAAATTCCAGACAGCTGTGATTATTTTTTACTTTTGTCATTTTTCATCAAGCAACAGAGGACCA
ATGCAACAAGAACACAAATGTGAAATCATGGGCTGACTGAGACAATTCTGTCCATGTAAAGATCCTCTGGAAAAAGACTCCGAGAGTTATAACTACTGTA
GTATAAATATAGGAACTAAGTTAAACTTGTACATTTCTGTTGATCACGCCGTTATGTTGCCTCAAATAGTTTTAGAAGAGAAAAAAAAATATATCCTTGT
TTTCCACACTATGTGTGTTGTTCCCAAAAGAATGACTGTTTTGGTTCATCAGTGAATTCACCATCCAGGAGAGACTGTGGTATATATTTTAAACCTGTTG
GGCCAATGAGAAAAGAACCACACTGGAGATCATGATGAACTTTTGGCTGAACCTCATCACTCGAACTCCAGCTTCAAGAATGTGTTTTCATGCCCGGCCT
TTGTTCCTCCATAAATGTGTCCTTTAGTTTCAAACAGATCTTTATAGTTCGTGCTTCATAAGCCAATTCTTATTATTATTTTTGGGGGACTCTTCTTCAA
AGAGCTTGCCAATGAAGATTTAAAGACAGAGCAGGAGCTTCTTCCAGGAGTTCTGAGCCTTGGTTGTGGACAAAACAATCTTAAGTTGGGCAGCTTTCCT
CAACACAAAAAAAAGTTATTAATGGTCATTGAACCATAACTAGGACTTTATCAGAAACTCAAAGCTTGGGGGATAAAAAGGAGCAAGAGAATACTGTAAC
AAACTTCGTACAGAGTTCGGTCTATTAATTGTTTCATGTTAGATATTCTATGTGTTTACCTCAATTGAAAAAAAAAAGAATGTTTTTGCTAGTATCAGAT
CTGCTGTGGAATTGGTATTGTATGTCCATGAATTCTTCTTTTCTCAGCACGTGTTCCTCACTAGAAGAAAATGCTGTTACCTTTAAGCTTTGTCAAATTT
ACATTAAAATACTTGTATGAGGACTGTGACGTTATGTTAAAAAAAAAAAGGTGTTAAGTCACAAAAAGCGGTAATAAATATTTCATTTTTGA
  • refseq_MEIS2.F4 (forward primer)
  • refseq_MEIS2.R4 (reverse primer)
  • Single exon skipping

Frame 0

SRSPLPGCVSAVRRAMATTTSGFRHFVLPPPTR
AAKLRLFNKPGSSQPANTY*HSLISQREKESERE
RARESERE*ERASERERERGRDKIPTRKGGEEV
QFLQTIHFFFLIFLTAFFEQYFKERGSYYRYRG
GKAKKGGRGEEKIQEAETPRGVLLEEKNGSERFL
LFIIINHHSFTTLTFRALIDSWSGKKP*NTTVR
LHVGC*RAARNLQFGGLTIFFFFFFFFFSFFFF
PTEGKRRERGGKEDRRGGGGEGGGGGGGGGGGRS
GGGGRRGKKRKRRNITEKKILRCLDWAFFPP*K
IAYWRIGRSLFGLEKKKRNLQPRSLSYPDWDIK
YTTHPGVYWSAD*WRKGTMSCPITAGWTE*GFPL
PCTETLTRRGRSPRFTT*TTGRRSTPHSTTART
PRTPMSCRPVWDPLSTTP*SGTRTRSMGTRCFL
C*LWSLRSASWRPALPGNLEWLAETSAPPTPSTR
TSRSSPSRFAPKSHFFPQIQSWTI**YKQYKY*
GFIFWS*KRSTNCAITSATDTLAV*RGKCPSTS
SLMKETAAPSQIMKNFQAPPQISLTITLLLGETT
MMQPQPTQQAPQGPPVGAMLPRAETTAVSKGMV
*TTV*LHLVQVTMMIRIRTKNARRKEAFSPK*Q
QIS*EHGSSSISHIRTLPKSRRNS*RKTQDLQFS
K*TTGLLMPEEE*YSP*LTSQIEQ*AKEQHIVQ
RVSPWGALCWMVSNTWGSGLQVCRACQGTTFLR
VVLWE*VWHSQVTLLPR*PHTLLN*DMDPQCIHI
CQAIPTTQP**CTEDPLPTLE*LCQHRAPQC*I
L*IPMLADRLWTFMPNSIRELKGKGNTRKNYFK
TF*TLTRC*HLI*NSRQL*LFFTFVIFHQATEDQ
CNKNTNVKSWAD*DNSVHVKILWKKTPRVITTV
V*I*ELS*TCTFLLITPLCCLK*F*KRKKNISL
FSTLCVLFPKE*LFWFISEFTIQERLWYIF*TCW
ANEKRTTLEIMMNFWLNLITRTPASRMCFHARP
LFLHKCVL*FQTDLYSSCFISQFLLLFLGDSSS
KSLPMKI*RQSRSFFQEF*ALVVDKTILSWAAFL
NTKKSY*WSLNHN*DFIRNSKLGG*KGAREYCN
KLRTEFGLLIVSC*IFYVFTSIEKKKNVFASIR
SAVELVLYVHEFFFSQHVFLTRRKCCYL*ALSNL
H*NTCMRTVTLC*KKKGVKSQKAVINISFL

Frame 1

PAPHSRDVSPPYDGLWPPRLPGSVISFSRRRPA
PPN*GSSISQAAANLPTPTDTHSSPRERKRARE
SERERASASESERASEKEREGETKYLPGKGGRKS
NFCKLFIFFS*FFSLLSLNNTLKREDRIIDTAG
AKLKKGGGGRKKFKKQKPLAEFYWKKKTGLKDS
SSSSSSTIIHSLP*HSGL*LTAGVAKSHETRQFG
YMWAADGPLVTFSSGA*QFFSSFSSFSFLSFFF
QLRGREEKEGERRTEEEEEGRGEEEEVEEEEED
QEEEEEEEKREKEEISQKKKFFVV*TGLFFPPKK
*HIGELGEVSLVWKKKKGIFSLDHFLIRTGILN
IRHIQEFIGAQTDGAKVR*AAPLRRDGRSRGSR
FHVRRPSRAAADPPGSPPEPRAAAPRHTALRRAR
PAPQCHAGQYGIRCQRRLEAGQGRDLWAPVVSS
VSSGL*EVRAGDLHSPGTWSGWRRRLLLRLLQR
GHRGLRQAGSRRKATFFLKSRAGQFDDTSNTSTK
VSSFGVRKGPRTVR*LLPPIH*LFEGENAHRPR
H**KRRQLQVRS*RTFRLLHKSR*P*PFFLARP
R*CNLNPLSRHPRALQWGPCFPERRQQQ*ARGWF
RQQCSFTWYR*R**SG*GQKTPEEKRHFPQSSN
KYHESMALPASHTSVPFRRAEETVSARHRTYNS
PSKQLVY*CQKKNSTAHD*PVKSSSEPRSSI*SR
GSAHGELCVGWSATHGDPACRFAEHARGLRFSG
WSYGNEYGTAKLHSSPDDPTPYSIKTWTPNAFI
FAKPSPPPSHDDARRTPYPPWNDYVSTEPHNVKF
CRSQCWRTGYGHSCPIV*GNSREKETHAKTILR
LSEL*PDVDT*YEIPDSCDYFLLLSFFIKQQRT
NATRTQM*NHGLTETILSM*RSSGKRLREL*LL*
YKYRN*VKLVHFC*SRRYVASNSFRREKKIYPC
FPHYVCCSQKNDCFGSSVNSPSRRDCGIYFKPV
GPMRKEPHWRS**TFG*TSSLELQLQECVFMPGL
CSSINVSFSFKQIFIVRAS*ANSYYYFWGTLLQ
RACQ*RFKDRAGASSRSSEPWLWTKQS*VGQLS
STQKKVINGH*TITRTLSETQSLGDKKEQENTVT
NFVQSSVY*LFHVRYSMCLPQLKKKRMFLLVSD
LLWNWYCMSMNSSFLSTCSSLEENAVTFKLCQI
YIKILV*GL*RYVKKKKVLSHKKR**IFHF*

Frame 2

PLPTPGMCLRRTTGYGHHDFRVPSFRSPAADPR
RQTEALQ*ARQQPTCQHLLTLTHLPERERERER
ASARERARVRASERARKRERERQNTYQERGGGS
PIFANYSFFFLDFSHCFL*TIL*RERIVL*IPRG
QS*KRGEGGGKNSRSRNPSRSFTGRKKRV*KIP
PLHHHQPSFIHYLDIPGFD*QLEWQKAMKHDSS
VTCGLLTGRS*PSVRGLDNFFLLFLLFLFFLFFS
N*GEEKRKRGKGGPKRRRRGGGRRRRWRRRRKI
RRRRKKRKKEKKKKYHRKKNSSLSRLGFFSPLK
NSILENWEKSLWFGKKKKESSA*ITFLSGLGY*I
YDTSRSLLERRLMAQRYDELPHYGGMDGVGVPA
SMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAH
APHPNVMPASMGSAVNDALKRDKDAIYGHPLFPL
LALVFEKCELATCTPREPGVAGGDVCSSDSFNE
DIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVL
RFHLLELEKVHELCDNFCHRYISCLKGKMPIDLV
IDERDGSSKSDHEELSGSSTNLADHNPSSWRDH
DDATSTHSAGTPGPSSGGHASQSGDNSSEQGDG
LDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVAT
NIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTIL
QVNNWFINARRRIVQPMIDQSNRAVSQGAAYSP
EGQPMGSFVLDGQQHMGIRPAGLQSMPGDYVSQG
GPMGMSMAQPSYTPPQMTPHPTQLRHGPPMHSY
LPSHPHHPAMMMHGGPPTHPGMTMSAQSPTMLN
SVDPNVGGQVMDIHAQ*YKGTQGKRKHTQKLF*D
FLNFDQMLTLNMKFQTAVIIFYFCHFSSSNRGP
MQQEHKCEIMG*LRQFCPCKDPLEKDSESYNYC
SINIGTKLNLYISVDHAVMLPQIVLEEKKKYILV
FHTMCVVPKRMTVLVHQ*IHHPGETVVYILNLL
GQ*EKNHTGDHDELLAEPHHSNSSFKNVFSCPA
FVPP*MCPLVSNRSL*FVLHKPILIIIFGGLFFK
ELANEDLKTEQELLPGVLSLGCGQNNLKLGSFP
QHKKKLLMVIEP*LGLYQKLKAWGIKRSKRIL*
QTSYRVRSINCFMLDILCVYLN*KKKECFC*YQI
CCGIGIVCP*ILLFSARVPH*KKMLLPLSFVKF
TLKYLYEDCDVMLKKKRC*VTKSGNKYFIF

Sequence NM_170674

TCCCGCTCCCCACTCCCGGGATGTGTCTCCGCCGTACGACGGGCTATGGCCACCACGACTTCCGGGTTCCGTCATTTCGTTCTCCCGCCGCCGACCCGCG
CCGCCAAACTGAGGCTCTTCAATAAGCCAGGCAGCAGCCAACCTGCCAACACCTACTGACACTCACTCATCTCCCAGAGAGAGAAAGAGAGCGAGAGAGA
GCGAGCGCGAGAGAGCGAGCGCGAGTGAGAGCGAGCGAGCGAGCGAGAAAGAGAGAGAGGGAGAGACAAAATACCTACCAGGAAAGGGGGGGAGGAAGTC
CAATTTTTGCAAACTATTCATTTTTTTTTCTTGATTTTTCTCACTGCTTTCTTTGAACAATACTTTAAAGAGAGAGGATCGTATTATAGATACCGCGGGG
GCAAAGCTAAAAAAGGGGGGAGGGGGGAGGAAAAAATTCAAGAAGCAGAAACCCCTCGCGGAGTTTTACTGGAAGAAAAAAACGGGTCTGAAAGATTCCT
CCTCTTCATCATCATCAACCATCATTCATTCACTACCTTGACATTCCGGGCTTTGATTGACAGCTGGAGTGGCAAAAAGCCATGAAACACGACAGTTCGG
TTACATGTGGGCTGCTGACGGGCCGCTCGTAACCTTCAGTTCGGGGGCTTGACAATTTTTTTCTTCTTTTTCTTCTTTTTCTTTTCTTTCTTTTTTTTTC
CAACTGAGGGGAAGAGAAGAGAAAGAGGGGGAAAGGAGGACCGAAGAGGAGGAGGAGGGGAGGGGGGAGGAGGAGGAGGTGGAGGAGGAGGAGGAAGATC
AGGAGGAGGAGGAAGAAGAGGAAAAAAGAGAAAAAGAAGAAATATCACAGAAAAAAAAATTCTTCGTTGTCTAGACTGGGCTTTTTTTCCCCCCTAAAAA
ATAGCATATTGGAGAATTGGGAGAAGTCTCTTTGGTTTGGAAAAAAAAAAAAGGAATCTTCAGCCTAGATCACTTTCTTATCCGGACTGGGATATTAAAT
ATACGACACATCCAGGAGTTTATTGGAGCGCAGACTGATGGCGCAAAGGTACGATGAGCTGCCCCATTACGGCGGGATGGACGGAGTAGGGGTTCCCGCT
TCCATGTACGGAGACCCTCACGCGCCGCGGCCGATCCCCCCGGTTCACCACCTGAACCACGGGCCGCCGCTCCACGCCACACAGCACTACGGCGCGCACG
CCCCGCACCCCAATGTCATGCCGGCCAGTATGGGATCCGCTGTCAACGACGCCTTGAAGCGGGACAAGGACGCGATCTATGGGCACCCGTTGTTTCCTCT
GTTAGCTCTGGTCTTTGAGAAGTGCGAGCTGGCGACCTGCACTCCCCGGGAACCTGGAGTGGCTGGCGGAGACGTCTGCTCCTCCGACTCCTTCAACGAG
GACATCGCGGTCTTCGCCAAGCAGGTTCGCGCCGAAAAGCCACTTTTTTCCTCAAATCCAGAGCTGGACAATTTGATGATACAAGCAATACAAGTACTAA
GGTTTCATCTTTTGGAGTTAGAAAAGGTCCACGAACTGTGCGATAACTTCTGCCACCGATACATTAGCTGTTTGAAGGGGAAAATGCCCATCGACCTCGT
CATTGATGAAAGAGACGGCAGCTCCAAGTCAGATCATGAAGAACTTTCAGGCTCCTCCACAAATCTCGCTGACCATAACCCTTCTTCTTGGCGAGACCAC
GATGATGCAACCTCAACCCACTCAGCAGGCACCCCAGGGCCCTCCAGTGGGGGCCATGCTTCCCAGAGCGGAGACAACAGCAGTGAGCAAGGGGATGGTT
TAGACAACAGTGTAGCTTCACCTGGTACAGGTGACGATGATGATCCGGATAAGGACAAAAAACGCCAGAAGAAAAGAGGCATTTTCCCCAAAGTAGCAAC
AAATATCATGAGAGCATGGCTCTTCCAGCATCTCACACATCCGTACCCTTCCGAAGAGCAGAAGAAACAGTTAGCGCAAGACACAGGACTTACAATTCTC
CAAGTAAACAACTGGTTTATTAATGCCAGAAGAAGAATAGTACAGCCCATGATTGACCAGTCAAATCGAGCAGTGAGCCAAGGAGCAGCATATAGTCCAG
AGGGTCAGCCCATGGGGAGCTTTGTGTTGGATGGTCAGCAACACATGGGGATCCGGCCTGCAGGACCTATGAGTGGAATGGGCATGAATATGGGCATGGA
TGGGCAATGGCACTACATGTAACCTTCATCATGTAAAGCAATCGCAAAGCAAGGGGGAAGTTTGCAGAGCATGCCAGGGGACTACGTTTCTCAGGGTGGT
CCTATGGGAATGAGTATGGCACAGCCAAGTTACACTCCTCCCCAGATGACCCCACACCCTACTCAATTAAGACATGGACCCCCAATGCATTCATATTTGC
CAAGCCATCCCCACCACCCAGCCATGATGATGCACGGAGGACCCCCTACCCACCCTGGAATGACTATGTCAGCACAGAGCCCCACAATGTTAAATTCTGT
AGATCCCAATGTTGGCGGACAGGTTATGGACATTCATGCCCAATAGTATAAGGGAACTCAAGGGAAAAGGAAACACACGCAAAAACTATTTTAAGACTTT
CTGAACTTTGACCAGATGTTGACACTTAATATGAAATTCCAGACAGCTGTGATTATTTTTTACTTTTGTCATTTTTCATCAAGCAACAGAGGACCAATGC
AACAAGAACACAAATGTGAAATCATGGGCTGACTGAGACAATTCTGTCCATGTAAAGATCCTCTGGAAAAAGACTCCGAGAGTTATAACTACTGTAGTAT
AAATATAGGAACTAAGTTAAACTTGTACATTTCTGTTGATCACGCCGTTATGTTGCCTCAAATAGTTTTAGAAGAGAAAAAAAAATATATCCTTGTTTTC
CACACTATGTGTGTTGTTCCCAAAAGAATGACTGTTTTGGTTCATCAGTGAATTCACCATCCAGGAGAGACTGTGGTATATATTTTAAACCTGTTGGGCC
AATGAGAAAAGAACCACACTGGAGATCATGATGAACTTTTGGCTGAACCTCATCACTCGAACTCCAGCTTCAAGAATGTGTTTTCATGCCCGGCCTTTGT
TCCTCCATAAATGTGTCCTTTAGTTTCAAACAGATCTTTATAGTTCGTGCTTCATAAGCCAATTCTTATTATTATTTTTGGGGGACTCTTCTTCAAAGAG
CTTGCCAATGAAGATTTAAAGACAGAGCAGGAGCTTCTTCCAGGAGTTCTGAGCCTTGGTTGTGGACAAAACAATCTTAAGTTGGGCAGCTTTCCTCAAC
ACAAAAAAAAGTTATTAATGGTCATTGAACCATAACTAGGACTTTATCAGAAACTCAAAGCTTGGGGGATAAAAAGGAGCAAGAGAATACTGTAACAAAC
TTCGTACAGAGTTCGGTCTATTAATTGTTTCATGTTAGATATTCTATGTGTTTACCTCAATTGAAAAAAAAAAGAATGTTTTTGCTAGTATCAGATCTGC
TGTGGAATTGGTATTGTATGTCCATGAATTCTTCTTTTCTCAGCACGTGTTCCTCACTAGAAGAAAATGCTGTTACCTTTAAGCTTTGTCAAATTTACAT
TAAAATACTTGTATGAGGACTGTGACGTTATGTTAAAAAAAAAAAGGTGTTAAGTCACAAAAAGCGGTAATAAATATTTCATTTTTGA
  • refseq_MEIS2.F4 (forward primer)
  • refseq_MEIS2.R4 (reverse primer)
  • Single exon skipping

Frame 0

SRSPLPGCVSAVRRAMATTTSGFRHFVLPPPTR
AAKLRLFNKPGSSQPANTY*HSLISQREKESERE
RARESERE*ERASERERERGRDKIPTRKGGEEV
QFLQTIHFFFLIFLTAFFEQYFKERGSYYRYRG
GKAKKGGRGEEKIQEAETPRGVLLEEKNGSERFL
LFIIINHHSFTTLTFRALIDSWSGKKP*NTTVR
LHVGC*RAARNLQFGGLTIFFFFFFFFFSFFFF
PTEGKRRERGGKEDRRGGGGEGGGGGGGGGGGRS
GGGGRRGKKRKRRNITEKKILRCLDWAFFPP*K
IAYWRIGRSLFGLEKKKRNLQPRSLSYPDWDIK
YTTHPGVYWSAD*WRKGTMSCPITAGWTE*GFPL
PCTETLTRRGRSPRFTT*TTGRRSTPHSTTART
PRTPMSCRPVWDPLSTTP*SGTRTRSMGTRCFL
C*LWSLRSASWRPALPGNLEWLAETSAPPTPSTR
TSRSSPSRFAPKSHFFPQIQSWTI**YKQYKY*
GFIFWS*KRSTNCAITSATDTLAV*RGKCPSTS
SLMKETAAPSQIMKNFQAPPQISLTITLLLGETT
MMQPQPTQQAPQGPPVGAMLPRAETTAVSKGMV
*TTV*LHLVQVTMMIRIRTKNARRKEAFSPK*Q
QIS*EHGSSSISHIRTLPKSRRNS*RKTQDLQFS
K*TTGLLMPEEE*YSP*LTSQIEQ*AKEQHIVQ
RVSPWGALCWMVSNTWGSGLQDL*VEWA*IWAW
MGNGTTCNLHHVKQSQSKGEVCRACQGTTFLRVV
LWE*VWHSQVTLLPR*PHTLLN*DMDPQCIHIC
QAIPTTQP**CTEDPLPTLE*LCQHRAPQC*IL
*IPMLADRLWTFMPNSIRELKGKGNTRKNYFKTF
*TLTRC*HLI*NSRQL*LFFTFVIFHQATEDQC
NKNTNVKSWAD*DNSVHVKILWKKTPRVITTVV
*I*ELS*TCTFLLITPLCCLK*F*KRKKNISLFS
TLCVLFPKE*LFWFISEFTIQERLWYIF*TCWA
NEKRTTLEIMMNFWLNLITRTPASRMCFHARPL
FLHKCVL*FQTDLYSSCFISQFLLLFLGDSSSKS
LPMKI*RQSRSFFQEF*ALVVDKTILSWAAFLN
TKKSY*WSLNHN*DFIRNSKLGG*KGAREYCNK
LRTEFGLLIVSC*IFYVFTSIEKKKNVFASIRSA
VELVLYVHEFFFSQHVFLTRRKCCYL*ALSNLH
*NTCMRTVTLC*KKKGVKSQKAVINISFL

Frame 1

PAPHSRDVSPPYDGLWPPRLPGSVISFSRRRPA
PPN*GSSISQAAANLPTPTDTHSSPRERKRARE
SERERASASESERASEKEREGETKYLPGKGGRKS
NFCKLFIFFS*FFSLLSLNNTLKREDRIIDTAG
AKLKKGGGGRKKFKKQKPLAEFYWKKKTGLKDS
SSSSSSTIIHSLP*HSGL*LTAGVAKSHETRQFG
YMWAADGPLVTFSSGA*QFFSSFSSFSFLSFFF
QLRGREEKEGERRTEEEEEGRGEEEEVEEEEED
QEEEEEEEKREKEEISQKKKFFVV*TGLFFPPKK
*HIGELGEVSLVWKKKKGIFSLDHFLIRTGILN
IRHIQEFIGAQTDGAKVR*AAPLRRDGRSRGSR
FHVRRPSRAAADPPGSPPEPRAAAPRHTALRRAR
PAPQCHAGQYGIRCQRRLEAGQGRDLWAPVVSS
VSSGL*EVRAGDLHSPGTWSGWRRRLLLRLLQR
GHRGLRQAGSRRKATFFLKSRAGQFDDTSNTSTK
VSSFGVRKGPRTVR*LLPPIH*LFEGENAHRPR
H**KRRQLQVRS*RTFRLLHKSR*P*PFFLARP
R*CNLNPLSRHPRALQWGPCFPERRQQQ*ARGWF
RQQCSFTWYR*R**SG*GQKTPEEKRHFPQSSN
KYHESMALPASHTSVPFRRAEETVSARHRTYNS
PSKQLVY*CQKKNSTAHD*PVKSSSEPRSSI*SR
GSAHGELCVGWSATHGDPACRTYEWNGHEYGHG
WAMALHVTFIM*SNRKARGKFAEHARGLRFSGW
SYGNEYGTAKLHSSPDDPTPYSIKTWTPNAFIFA
KPSPPPSHDDARRTPYPPWNDYVSTEPHNVKFC
RSQCWRTGYGHSCPIV*GNSREKETHAKTILRL
SEL*PDVDT*YEIPDSCDYFLLLSFFIKQQRTNA
TRTQM*NHGLTETILSM*RSSGKRLREL*LL*Y
KYRN*VKLVHFC*SRRYVASNSFRREKKIYPCF
PHYVCCSQKNDCFGSSVNSPSRRDCGIYFKPVGP
MRKEPHWRS**TFG*TSSLELQLQECVFMPGLC
SSINVSFSFKQIFIVRAS*ANSYYYFWGTLLQR
ACQ*RFKDRAGASSRSSEPWLWTKQS*VGQLSST
QKKVINGH*TITRTLSETQSLGDKKEQENTVTN
FVQSSVY*LFHVRYSMCLPQLKKKRMFLLVSDL
LWNWYCMSMNSSFLSTCSSLEENAVTFKLCQIYI
KILV*GL*RYVKKKKVLSHKKR**IFHF*

Frame 2

PLPTPGMCLRRTTGYGHHDFRVPSFRSPAADPR
RQTEALQ*ARQQPTCQHLLTLTHLPERERERER
ASARERARVRASERARKRERERQNTYQERGGGS
PIFANYSFFFLDFSHCFL*TIL*RERIVL*IPRG
QS*KRGEGGGKNSRSRNPSRSFTGRKKRV*KIP
PLHHHQPSFIHYLDIPGFD*QLEWQKAMKHDSS
VTCGLLTGRS*PSVRGLDNFFLLFLLFLFFLFFS
N*GEEKRKRGKGGPKRRRRGGGRRRRWRRRRKI
RRRRKKRKKEKKKKYHRKKNSSLSRLGFFSPLK
NSILENWEKSLWFGKKKKESSA*ITFLSGLGY*I
YDTSRSLLERRLMAQRYDELPHYGGMDGVGVPA
SMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAH
APHPNVMPASMGSAVNDALKRDKDAIYGHPLFPL
LALVFEKCELATCTPREPGVAGGDVCSSDSFNE
DIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVL
RFHLLELEKVHELCDNFCHRYISCLKGKMPIDLV
IDERDGSSKSDHEELSGSSTNLADHNPSSWRDH
DDATSTHSAGTPGPSSGGHASQSGDNSSEQGDG
LDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVAT
NIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTIL
QVNNWFINARRRIVQPMIDQSNRAVSQGAAYSP
EGQPMGSFVLDGQQHMGIRPAGPMSGMGMNMGMD
GQWHYM*PSSCKAIAKQGGSLQSMPGDYVSQGG
PMGMSMAQPSYTPPQMTPHPTQLRHGPPMHSYL
PSHPHHPAMMMHGGPPTHPGMTMSAQSPTMLNSV
DPNVGGQVMDIHAQ*YKGTQGKRKHTQKLF*DF
LNFDQMLTLNMKFQTAVIIFYFCHFSSSNRGPM
QQEHKCEIMG*LRQFCPCKDPLEKDSESYNYCSI
NIGTKLNLYISVDHAVMLPQIVLEEKKKYILVF
HTMCVVPKRMTVLVHQ*IHHPGETVVYILNLLG
Q*EKNHTGDHDELLAEPHHSNSSFKNVFSCPAFV
PP*MCPLVSNRSL*FVLHKPILIIIFGGLFFKE
LANEDLKTEQELLPGVLSLGCGQNNLKLGSFPQ
HKKKLLMVIEP*LGLYQKLKAWGIKRSKRIL*QT
SYRVRSINCFMLDILCVYLN*KKKECFC*YQIC
CGIGIVCP*ILLFSARVPH*KKMLLPLSFVKFT
LKYLYEDCDVMLKKKRC*VTKSGNKYFIF

Sequence NM_172316

CCCGATGCCTCCTCTCCCTTCAACGCTTCTGCTGCTGCTCGCTGCTTGATGATGGCGGCCAGTATTTTAAAAAATAGCAAAATTATTCATCGGCTTCTTT
CCCTCCCGTGCCTCTGCGTGTGTGCGAGTGTGTGTGCGTGCGTGTGTGCGTGTCTGGGCGCGCGTGTTCCAGCGCTGTGCGAGCGGGCGGGCGGCGAGTG
CGTGTGAGTGGTGTGTGTGTGTGCGTGTGCAATCGTTACACGCTTTCGCCTCGCTCCAGCTTTTACCCCAGCAGCGCGATTCCCCCGGTTCTCCTGCTGC
CGCTGCTGCGCCGCTGCCGCCGTGGCTCGCGCGGCTCGGGGCGGGCACGGGCTGCGTAGGAGCCGCCGCCGGGGCCGCCGCTGGGGCCGCGCTGCCGCAG
CCGCTGCGCCGCCGCCTAGACTACTAGCCTGGGCTGCTTGTTTTGTCTCTGAAATTGACAAGGACGCAGGGAATCCGCTGCTAAATAATGTTTCTGTACG
ATGAGCTGCCCCATTACGGCGGGATGGACGGAGTAGGGGTTCCCGCTTCCATGTACGGAGACCCTCACGCGCCGCGGCCGATCCCCCCGGTTCACCACCT
GAACCACGGGCCGCCGCTCCACGCCACACAGCACTACGGCGCGCACGCCCCGCACCCCAATGTCATGCCGGCCAGTATGGGATCCGCTGTCAACGACGCC
TTGAAGCGGGACAAGGACGCGATCTATGGCTCTGGTCTTTGAGAAGTGCGAGCTGGCGACCTGCACTCCCCGGGAACCTGGAGTGGCTGGCGGAGACGTC
TGCTCCTCCGACTCCTTCAACGAGGACATCGCGGTCTTCGCCAAGCAGGTTCGCGCCGAAAAGCCACTTTTTTCCTCAAATCCAGAGCTGGACAATTTGA
TGATACAAGCAATACAAGTACTAAGGTTTCATCTTTTGGAGTTAGAAAAGGTCCACGAACTGTGCGATAACTTCTGCCACCGATACATTAGCTGTTTGAA
GGGGAAAATGCCCATCGACCTCGTCATTGATGAAAGAGACGGCAGCTCCAAGTCAGATCATGAAGAACTTTCAGGCTCCTCCACAAATCTCGCTGACCAT
AACCCTTCTTCTTGGCGAGACCACGATGATGCAACCTCAACCCACTCAGCAGGCACCCCAGGGCCCTCCAGTGGGGGCCATGCTTCCCAGAGCGGAGACA
ACAGCAGTGAGCAAGGGGATGGTTTAGACAACAGTGTAGCTTCACCTGGTACAGGTGACGATGATGATCCGGATAAGGACAAAAAACGCCAGAAGAAAAG
AGGCATTTTCCCCAAAGTAGCAACAAATATCATGAGAGCATGGCTCTTCCAGCATCTCACACATCCGTACCCTTCCGAAGAGCAGAAGAAACAGTTAGCG
CAAGACACAGGACTTACAATTCTCCAAGTAAACAACTGGTTTATTAATGCCAGAAGAAGAATAGTACAGCCCATGATTGACCAGTCAAATCGAGCAGTGA
GCCAAGGAGCAGCATATAGTCCAGAGGGTCAGCCCATGGGGAGCTTTGTGTTGGATGGTCAGCAACACATGGGGATCCGGCCTGCAGGACCTATGAGTGG
AATGGGCATGAATATGGGCATGGATGGGCAATGGCACTACATGTAACCTTCATCATGTAAAGCAATCGCAAAGCAAGGGGGAAGTTTGCAGAGCATGCCA
GGGGACTACGTTTCTCAGGGTGGTCCTATGGGAATGAGTATGGCACAGCCAAGTTACACTCCTCCCCAGATGACCCCACACCCTACTCAATTAAGACATG
GACCCCCAATGCATTCATATTTGCCAAGCCATCCCCACCACCCAGCCATGATGATGCACGGAGGACCCCCTACCCACCCTGGAATGACTATGTCAGCACA
GAGCCCCACAATGTTAAATTCTGTAGATCCCAATGTTGGCGGACAGGTTATGGACATTCATGCCCAATAGTATAAGGGAACTCAAGGGAAAAGGAAACAC
ACGCAAAAACTATTTTAAGACTTTCTGAACTTTGACCAGATGTTGACACTTAATATGAAATTCCAGACAGCTGTGATTATTTTTTACTTTTGTCATTTTT
CATCAAGCAACAGAGGACCAATGCAACAAGAACACAAATGTGAAATCATGGGCTGACTGAGACAATTCTGTCCATGTAAAGATCCTCTGGAAAAAGACTC
CGAGAGTTATAACTACTGTAGTATAAATATAGGAACTAAGTTAAACTTGTACATTTCTGTTGATCACGCCGTTATGTTGCCTCAAATAGTTTTAGAAGAG
AAAAAAAAATATATCCTTGTTTTCCACACTATGTGTGTTGTTCCCAAAAGAATGACTGTTTTGGTTCATCAGTGAATTCACCATCCAGGAGAGACTGTGG
TATATATTTTAAACCTGTTGGGCCAATGAGAAAAGAACCACACTGGAGATCATGATGAACTTTTGGCTGAACCTCATCACTCGAACTCCAGCTTCAAGAA
TGTGTTTTCATGCCCGGCCTTTGTTCCTCCATAAATGTGTCCTTTAGTTTCAAACAGATCTTTATAGTTCGTGCTTCATAAGCCAATTCTTATTATTATT
TTTGGGGGACTCTTCTTCAAAGAGCTTGCCAATGAAGATTTAAAGACAGAGCAGGAGCTTCTTCCAGGAGTTCTGAGCCTTGGTTGTGGACAAAACAATC
TTAAGTTGGGCAGCTTTCCTCAACACAAAAAAAAGTTATTAATGGTCATTGAACCATAACTAGGACTTTATCAGAAACTCAAAGCTTGGGGGATAAAAAG
GAGCAAGAGAATACTGTAACAAACTTCGTACAGAGTTCGGTCTATTAATTGTTTCATGTTAGATATTCTATGTGTTTACCTCAATTGAAAAAAAAAAGAA
TGTTTTTGCTAGTATCAGATCTGCTGTGGAATTGGTATTGTATGTCCATGAATTCTTCTTTTCTCAGCACGTGTTCCTCACTAGAAGAAAATGCTGTTAC
CTTTAAGCTTTGTCAAATTTACATTAAAATACTTGTATGAGGACTGTGACGTTATGTTAAAAAAAAAAAGGTGTTAAGTCACAAAAAGCGGTAATAAATA
TTTCATTTTTGA
  • refseq_MEIS2.F4 (forward primer)
  • refseq_MEIS2.R4 (reverse primer)
  • Single exon skipping

Frame 0

PDASSPFNASAAARCLMMAASILKNSKIIHRLL
SLPCLCVCASVCACVCACLGARVPALCERAGGEC
V*VVCVCACAIVTRFRLAPAFTPAARFPRFSCC
RCCAAAAVARAARGGHGLRRSRRRGRRWGRAAA
AAAPPPRLLAWAACFVSEIDKDAGNPLLNNVSVR
*AAPLRRDGRSRGSRFHVRRPSRAAADPPGSPP
EPRAAAPRHTALRRARPAPQCHAGQYGIRCQRR
LEAGQGRDLWLWSLRSASWRPALPGNLEWLAETS
APPTPSTRTSRSSPSRFAPKSHFFPQIQSWTI*
*YKQYKY*GFIFWS*KRSTNCAITSATDTLAV*
RGKCPSTSSLMKETAAPSQIMKNFQAPPQISLTI
TLLLGETTMMQPQPTQQAPQGPPVGAMLPRAET
TAVSKGMV*TTV*LHLVQVTMMIRIRTKNARRK
EAFSPK*QQIS*EHGSSSISHIRTLPKSRRNS*R
KTQDLQFSK*TTGLLMPEEE*YSP*LTSQIEQ*
AKEQHIVQRVSPWGALCWMVSNTWGSGLQDL*V
EWA*IWAWMGNGTTCNLHHVKQSQSKGEVCRACQ
GTTFLRVVLWE*VWHSQVTLLPR*PHTLLN*DM
DPQCIHICQAIPTTQP**CTEDPLPTLE*LCQH
RAPQC*IL*IPMLADRLWTFMPNSIRELKGKGNT
RKNYFKTF*TLTRC*HLI*NSRQL*LFFTFVIF
HQATEDQCNKNTNVKSWAD*DNSVHVKILWKKT
PRVITTVV*I*ELS*TCTFLLITPLCCLK*F*KR
KKNISLFSTLCVLFPKE*LFWFISEFTIQERLW
YIF*TCWANEKRTTLEIMMNFWLNLITRTPASR
MCFHARPLFLHKCVL*FQTDLYSSCFISQFLLLF
LGDSSSKSLPMKI*RQSRSFFQEF*ALVVDKTI
LSWAAFLNTKKSY*WSLNHN*DFIRNSKLGG*K
GAREYCNKLRTEFGLLIVSC*IFYVFTSIEKKKN
VFASIRSAVELVLYVHEFFFSQHVFLTRRKCCY
L*ALSNLH*NTCMRTVTLC*KKKGVKSQKAVIN
ISFL

Frame 1

PMPPLPSTLLLLLAA**WRPVF*KIAKLFIGFF
PSRASACVRVCVRACVRVWARVFQRCASGRAAS
ACEWCVCVRVQSLHAFASLQLLPQQRDSPGSPAA
AAAPLPPWLARLGAGTGCVGAAAGAAAGAALPQ
PLRRRLDY*PGLLVLSLKLTRTQGIRC*IMFLY
DELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHL
NHGPPLHATQHYGAHAPHPNVMPASMGSAVNDA
LKRDKDAIYGSGL*EVRAGDLHSPGTWSGWRRR
LLLRLLQRGHRGLRQAGSRRKATFFLKSRAGQFD
DTSNTSTKVSSFGVRKGPRTVR*LLPPIH*LFE
GENAHRPRH**KRRQLQVRS*RTFRLLHKSR*P
*PFFLARPR*CNLNPLSRHPRALQWGPCFPERRQ
QQ*ARGWFRQQCSFTWYR*R**SG*GQKTPEEK
RHFPQSSNKYHESMALPASHTSVPFRRAEETVS
ARHRTYNSPSKQLVY*CQKKNSTAHD*PVKSSSE
PRSSI*SRGSAHGELCVGWSATHGDPACRTYEW
NGHEYGHGWAMALHVTFIM*SNRKARGKFAEHA
RGLRFSGWSYGNEYGTAKLHSSPDDPTPYSIKTW
TPNAFIFAKPSPPPSHDDARRTPYPPWNDYVST
EPHNVKFCRSQCWRTGYGHSCPIV*GNSREKET
HAKTILRLSEL*PDVDT*YEIPDSCDYFLLLSFF
IKQQRTNATRTQM*NHGLTETILSM*RSSGKRL
REL*LL*YKYRN*VKLVHFC*SRRYVASNSFRR
EKKIYPCFPHYVCCSQKNDCFGSSVNSPSRRDCG
IYFKPVGPMRKEPHWRS**TFG*TSSLELQLQE
CVFMPGLCSSINVSFSFKQIFIVRAS*ANSYYY
FWGTLLQRACQ*RFKDRAGASSRSSEPWLWTKQS
*VGQLSSTQKKVINGH*TITRTLSETQSLGDKK
EQENTVTNFVQSSVY*LFHVRYSMCLPQLKKKR
MFLLVSDLLWNWYCMSMNSSFLSTCSSLEENAVT
FKLCQIYIKILV*GL*RYVKKKKVLSHKKR**I
FHF*

Frame 2

RCLLSLQRFCCCSLLDDGGQYFKK*QNYSSASF
PPVPLRVCECVCVRVCVSGRACSSAVRAGGRRV
RVSGVCVCVCNRYTLSPRSSFYPSSAIPPVLLL
PLLRRCRRGSRGSGRARAA*EPPPGPPLGPRCRS
RCAAA*TTSLGCLFCL*N*QGRRESAAK*CFCT
MSCPITAGWTE*GFPLPCTETLTRRGRSPRFTT
*TTGRRSTPHSTTARTPRTPMSCRPVWDPLSTTP
*SGTRTRSMALVFEKCELATCTPREPGVAGGDV
CSSDSFNEDIAVFAKQVRAEKPLFSSNPELDNL
MIQAIQVLRFHLLELEKVHELCDNFCHRYISCLK
GKMPIDLVIDERDGSSKSDHEELSGSSTNLADH
NPSSWRDHDDATSTHSAGTPGPSSGGHASQSGD
NSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKR
GIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLA
QDTGLTILQVNNWFINARRRIVQPMIDQSNRAV
SQGAAYSPEGQPMGSFVLDGQQHMGIRPAGPMSG
MGMNMGMDGQWHYM*PSSCKAIAKQGGSLQSMP
GDYVSQGGPMGMSMAQPSYTPPQMTPHPTQLRH
GPPMHSYLPSHPHHPAMMMHGGPPTHPGMTMSAQ
SPTMLNSVDPNVGGQVMDIHAQ*YKGTQGKRKH
TQKLF*DFLNFDQMLTLNMKFQTAVIIFYFCHF
SSSNRGPMQQEHKCEIMG*LRQFCPCKDPLEKDS
ESYNYCSINIGTKLNLYISVDHAVMLPQIVLEE
KKKYILVFHTMCVVPKRMTVLVHQ*IHHPGETV
VYILNLLGQ*EKNHTGDHDELLAEPHHSNSSFKN
VFSCPAFVPP*MCPLVSNRSL*FVLHKPILIII
FGGLFFKELANEDLKTEQELLPGVLSLGCGQNN
LKLGSFPQHKKKLLMVIEP*LGLYQKLKAWGIKR
SKRIL*QTSYRVRSINCFMLDILCVYLN*KKKE
CFC*YQICCGIGIVCP*ILLFSARVPH*KKMLL
PLSFVKFTLKYLYEDCDVMLKKKRC*VTKSGNKY
FIF

Sequence NM_172315

CTTTTCTGTTCGCCCTCTTCTCCCTGCTCTTTTTCCCTTTCCACCCCCCTCCTCTGTTCTCCCTCACCTCCTGCGCCCCCTCCCCCTTCCCGGGTTCTGA
CAGTACGATGAGCTGCCCCATTACGGCGGGATGGACGGAGTAGGGGTTCCCGCTTCCATGTACGGAGACCCTCACGCGCCGCGGCCGATCCCCCCGGTTC
ACCACCTGAACCACGGGCCGCCGCTCCACGCCACACAGCACTACGGCGCGCACGCCCCGCACCCCAATGTCATGCCGGCCAGTATGGGATCCGCTGTCAA
CGACGCCTTGAAGCGGGACAAGGACGCGATCTATGGGCACCCGTTGTTTCCTCTGTTAGCTCTGGTCTTTGAGAAGTGCGAGCTGGCGACCTGCACTCCC
CGGGAACCTGGAGTGGCTGGCGGAGACGTCTGCTCCTCCGACTCCTTCAACGAGGACATCGCGGTCTTCGCCAAGCAGGTTCGCGCCGAAAAGCCACTTT
TTTCCTCAAATCCAGAGCTGGACAATTTGATGATACAAGCAATACAAGTACTAAGGTTTCATCTTTTGGAGTTAGAAAAGGTCCACGAACTGTGCGATAA
CTTCTGCCACCGATACATTAGCTGTTTGAAGGGGAAAATGCCCATCGACCTCGTCATTGATGAAAGAGACGGCAGCTCCAAGTCAGATCATGAAGAACTT
TCAGGCTCCTCCACAAATCTCGCTGACCATAACCCTTCTTCTTGGCGAGACCACGATGATGCAACCTCAACCCACTCAGCAGGCACCCCAGGGCCCTCCA
GTGGGGGCCATGCTTCCCAGAGCGGAGACAACAGCAGTGAGCAAGGGGATGGTTTAGACAACAGTGTAGCTTCACCTGGTACAGGTGACGATGATGATCC
GGATAAGGACAAAAAACGCCAGAAGAAAAGAGGCATTTTCCCCAAAGTAGCAACAAATATCATGAGAGCATGGCTCTTCCAGCATCTCACACATCCGTAC
CCTTCCGAAGAGCAGAAGAAACAGTTAGCGCAAGACACAGGACTTACAATTCTCCAAGTAAACAACTGGTTTATTAATGCCAGAAGAAGAATAGTACAGC
CCATGATTGACCAGTCAAATCGAGCAGGTTTTCTTCTTGATCCTTCAGTGAGCCAAGGAGCAGCATATAGTCCAGAGGGTCAGCCCATGGGGAGCTTTGT
GTTGGATGGTCAGCAACACATGGGGATCCGGCCTGCAGGACCTATGAGTGGAATGGGCATGAATATGGGCATGGATGGGCAATGGCACTACATGTAACCT
TCATCATGTAAAGCAATCGCAAAGCAAGGGGGAAGTTTGCAGAGCATGCCAGGGGACTACGTTTCTCAGGGTGGTCCTATGGGAATGAGTATGGCACAGC
CAAGTTACACTCCTCCCCAGATGACCCCACACCCTACTCAATTAAGACATGGACCCCCAATGCATTCATATTTGCCAAGCCATCCCCACCACCCAGCCAT
GATGATGCACGGAGGACCCCCTACCCACCCTGGAATGACTATGTCAGCACAGAGCCCCACAATGTTAAATTCTGTAGATCCCAATGTTGGCGGACAGGTT
ATGGACATTCATGCCCAATAGTATAAGGGAACTCAAGGGAAAAGGAAACACACGCAAAAACTATTTTAAGACTTTCTGAACTTTGACCAGATGTTGACAC
TTAATATGAAATTCCAGACAGCTGTGATTATTTTTTACTTTTGTCATTTTTCATCAAGCAACAGAGGACCAATGCAACAAGAACACAAATGTGAAATCAT
GGGCTGACTGAGACAATTCTGTCCATGTAAAGATCCTCTGGAAAAAGACTCCGAGAGTTATAACTACTGTAGTATAAATATAGGAACTAAGTTAAACTTG
TACATTTCTGTTGATCACGCCGTTATGTTGCCTCAAATAGTTTTAGAAGAGAAAAAAAAATATATCCTTGTTTTCCACACTATGTGTGTTGTTCCCAAAA
GAATGACTGTTTTGGTTCATCAGTGAATTCACCATCCAGGAGAGACTGTGGTATATATTTTAAACCTGTTGGGCCAATGAGAAAAGAACCACACTGGAGA
TCATGATGAACTTTTGGCTGAACCTCATCACTCGAACTCCAGCTTCAAGAATGTGTTTTCATGCCCGGCCTTTGTTCCTCCATAAATGTGTCCTTTAGTT
TCAAACAGATCTTTATAGTTCGTGCTTCATAAGCCAATTCTTATTATTATTTTTGGGGGACTCTTCTTCAAAGAGCTTGCCAATGAAGATTTAAAGACAG
AGCAGGAGCTTCTTCCAGGAGTTCTGAGCCTTGGTTGTGGACAAAACAATCTTAAGTTGGGCAGCTTTCCTCAACACAAAAAAAAGTTATTAATGGTCAT
TGAACCATAACTAGGACTTTATCAGAAACTCAAAGCTTGGGGGATAAAAAGGAGCAAGAGAATACTGTAACAAACTTCGTACAGAGTTCGGTCTATTAAT
TGTTTCATGTTAGATATTCTATGTGTTTACCTCAATTGAAAAAAAAAAGAATGTTTTTGCTAGTATCAGATCTGCTGTGGAATTGGTATTGTATGTCCAT
GAATTCTTCTTTTCTCAGCACGTGTTCCTCACTAGAAGAAAATGCTGTTACCTTTAAGCTTTGTCAAATTTACATTAAAATACTTGTATGAGGACTGTGA
CGTTATGTTAAAAAAAAAAAGGTGTTAAGTCACAAAAAGCGGTAATAAATATTTCATTTTTGA
  • refseq_MEIS2.F4 (forward primer)
  • refseq_MEIS2.R4 (reverse primer)
  • Single exon skipping

Frame 0

LFCSPSSPCSFSLSTPLLCSPSPPAPPPPSRVL
TVR*AAPLRRDGRSRGSRFHVRRPSRAAADPPGS
PPEPRAAAPRHTALRRARPAPQCHAGQYGIRCQ
RRLEAGQGRDLWAPVVSSVSSGL*EVRAGDLHS
PGTWSGWRRRLLLRLLQRGHRGLRQAGSRRKATF
FLKSRAGQFDDTSNTSTKVSSFGVRKGPRTVR*
LLPPIH*LFEGENAHRPRH**KRRQLQVRS*RT
FRLLHKSR*P*PFFLARPR*CNLNPLSRHPRALQ
WGPCFPERRQQQ*ARGWFRQQCSFTWYR*R**S
G*GQKTPEEKRHFPQSSNKYHESMALPASHTSV
PFRRAEETVSARHRTYNSPSKQLVY*CQKKNSTA
HD*PVKSSRFSS*SFSEPRSSI*SRGSAHGELC
VGWSATHGDPACRTYEWNGHEYGHGWAMALHVT
FIM*SNRKARGKFAEHARGLRFSGWSYGNEYGTA
KLHSSPDDPTPYSIKTWTPNAFIFAKPSPPPSH
DDARRTPYPPWNDYVSTEPHNVKFCRSQCWRTG
YGHSCPIV*GNSREKETHAKTILRLSEL*PDVDT
*YEIPDSCDYFLLLSFFIKQQRTNATRTQM*NH
GLTETILSM*RSSGKRLREL*LL*YKYRN*VKL
VHFC*SRRYVASNSFRREKKIYPCFPHYVCCSQK
NDCFGSSVNSPSRRDCGIYFKPVGPMRKEPHWR
S**TFG*TSSLELQLQECVFMPGLCSSINVSFS
FKQIFIVRAS*ANSYYYFWGTLLQRACQ*RFKDR
AGASSRSSEPWLWTKQS*VGQLSSTQKKVINGH
*TITRTLSETQSLGDKKEQENTVTNFVQSSVY*
LFHVRYSMCLPQLKKKRMFLLVSDLLWNWYCMSM
NSSFLSTCSSLEENAVTFKLCQIYIKILV*GL*
RYVKKKKVLSHKKR**IFHF*

Frame 1

FSVRPLLPALFPFPPPSSVLPHLLRPLPLPGF*
QYDELPHYGGMDGVGVPASMYGDPHAPRPIPPV
HHLNHGPPLHATQHYGAHAPHPNVMPASMGSAVN
DALKRDKDAIYGHPLFPLLALVFEKCELATCTP
REPGVAGGDVCSSDSFNEDIAVFAKQVRAEKPL
FSSNPELDNLMIQAIQVLRFHLLELEKVHELCDN
FCHRYISCLKGKMPIDLVIDERDGSSKSDHEEL
SGSSTNLADHNPSSWRDHDDATSTHSAGTPGPS
SGGHASQSGDNSSEQGDGLDNSVASPGTGDDDDP
DKDKKRQKKRGIFPKVATNIMRAWLFQHLTHPY
PSEEQKKQLAQDTGLTILQVNNWFINARRRIVQ
PMIDQSNRAGFLLDPSVSQGAAYSPEGQPMGSFV
LDGQQHMGIRPAGPMSGMGMNMGMDGQWHYM*P
SSCKAIAKQGGSLQSMPGDYVSQGGPMGMSMAQ
PSYTPPQMTPHPTQLRHGPPMHSYLPSHPHHPAM
MMHGGPPTHPGMTMSAQSPTMLNSVDPNVGGQV
MDIHAQ*YKGTQGKRKHTQKLF*DFLNFDQMLT
LNMKFQTAVIIFYFCHFSSSNRGPMQQEHKCEIM
G*LRQFCPCKDPLEKDSESYNYCSINIGTKLNL
YISVDHAVMLPQIVLEEKKKYILVFHTMCVVPK
RMTVLVHQ*IHHPGETVVYILNLLGQ*EKNHTGD
HDELLAEPHHSNSSFKNVFSCPAFVPP*MCPLV
SNRSL*FVLHKPILIIIFGGLFFKELANEDLKT
EQELLPGVLSLGCGQNNLKLGSFPQHKKKLLMVI
EP*LGLYQKLKAWGIKRSKRIL*QTSYRVRSIN
CFMLDILCVYLN*KKKECFC*YQICCGIGIVCP
*ILLFSARVPH*KKMLLPLSFVKFTLKYLYEDCD
VMLKKKRC*VTKSGNKYFIF

Frame 2

FLFALFSLLFFPFHPPPLFSLTSCAPSPFPGSD
STMSCPITAGWTE*GFPLPCTETLTRRGRSPRF
TT*TTGRRSTPHSTTARTPRTPMSCRPVWDPLS
TTP*SGTRTRSMGTRCFLC*LWSLRSASWRPALP
GNLEWLAETSAPPTPSTRTSRSSPSRFAPKSHF
FPQIQSWTI**YKQYKY*GFIFWS*KRSTNCAI
TSATDTLAV*RGKCPSTSSLMKETAAPSQIMKNF
QAPPQISLTITLLLGETTMMQPQPTQQAPQGPP
VGAMLPRAETTAVSKGMV*TTV*LHLVQVTMMI
RIRTKNARRKEAFSPK*QQIS*EHGSSSISHIRT
LPKSRRNS*RKTQDLQFSK*TTGLLMPEEE*YS
P*LTSQIEQVFFLILQ*AKEQHIVQRVSPWGAL
CWMVSNTWGSGLQDL*VEWA*IWAWMGNGTTCNL
HHVKQSQSKGEVCRACQGTTFLRVVLWE*VWHS
QVTLLPR*PHTLLN*DMDPQCIHICQAIPTTQP
**CTEDPLPTLE*LCQHRAPQC*IL*IPMLADRL
WTFMPNSIRELKGKGNTRKNYFKTF*TLTRC*H
LI*NSRQL*LFFTFVIFHQATEDQCNKNTNVKS
WAD*DNSVHVKILWKKTPRVITTVV*I*ELS*TC
TFLLITPLCCLK*F*KRKKNISLFSTLCVLFPK
E*LFWFISEFTIQERLWYIF*TCWANEKRTTLE
IMMNFWLNLITRTPASRMCFHARPLFLHKCVL*F
QTDLYSSCFISQFLLLFLGDSSSKSLPMKI*RQ
SRSFFQEF*ALVVDKTILSWAAFLNTKKSY*WS
LNHN*DFIRNSKLGG*KGAREYCNKLRTEFGLLI
VSC*IFYVFTSIEKKKNVFASIRSAVELVLYVH
EFFFSQHVFLTRRKCCYL*ALSNLH*NTCMRTV
TLC*KKKGVKSQKAVINISFL

Sequence NM_170677

TCCCGCTCCCCACTCCCGGGATGTGTCTCCGCCGTACGACGGGCTATGGCCACCACGACTTCCGGGTTCCGTCATTTCGTTCTCCCGCCGCCGACCCGCG
CCGCCAAACTGAGGCTCTTCAATAAGCCAGGCAGCAGCCAACCTGCCAACACCTACTGACACTCACTCATCTCCCAGAGAGAGAAAGAGAGCGAGAGAGA
GCGAGCGCGAGAGAGCGAGCGCGAGTGAGAGCGAGCGAGCGAGCGAGAAAGAGAGAGAGGGAGAGACAAAATACCTACCAGGAAAGGGGGGGAGGAAGTC
CAATTTTTGCAAACTATTCATTTTTTTTTCTTGATTTTTCTCACTGCTTTCTTTGAACAATACTTTAAAGAGAGAGGATCGTATTATAGATACCGCGGGG
GCAAAGCTAAAAAAGGGGGGAGGGGGGAGGAAAAAATTCAAGAAGCAGAAACCCCTCGCGGAGTTTTACTGGAAGAAAAAAACGGGTCTGAAAGATTCCT
CCTCTTCATCATCATCAACCATCATTCATTCACTACCTTGACATTCCGGGCTTTGATTGACAGCTGGAGTGGCAAAAAGCCATGAAACACGACAGTTCGG
TTACATGTGGGCTGCTGACGGGCCGCTCGTAACCTTCAGTTCGGGGGCTTGACAATTTTTTTCTTCTTTTTCTTCTTTTTCTTTTCTTTCTTTTTTTTTC
CAACTGAGGGGAAGAGAAGAGAAAGAGGGGGAAAGGAGGACCGAAGAGGAGGAGGAGGGGAGGGGGGAGGAGGAGGAGGTGGAGGAGGAGGAGGAAGATC
AGGAGGAGGAGGAAGAAGAGGAAAAAAGAGAAAAAGAAGAAATATCACAGAAAAAAAAATTCTTCGTTGTCTAGACTGGGCTTTTTTTCCCCCCTAAAAA
ATAGCATATTGGAGAATTGGGAGAAGTCTCTTTGGTTTGGAAAAAAAAAAAAGGAATCTTCAGCCTAGATCACTTTCTTATCCGGACTGGGATATTAAAT
ATACGACACATCCAGGAGTTTATTGGAGCGCAGACTGATGGCGCAAAGGTACGATGAGCTGCCCCATTACGGCGGGATGGACGGAGTAGGGGTTCCCGCT
TCCATGTACGGAGACCCTCACGCGCCGCGGCCGATCCCCCCGGTTCACCACCTGAACCACGGGCCGCCGCTCCACGCCACACAGCACTACGGCGCGCACG
CCCCGCACCCCAATGTCATGCCGGCCAGTATGGGATCCGCTGTCAACGACGCCTTGAAGCGGGACAAGGACGCGATCTATGGGCACCCGTTGTTTCCTCT
GTTAGCTCTGGTCTTTGAGAAGTGCGAGCTGGCGACCTGCACTCCCCGGGAACCTGGAGTGGCTGGCGGAGACGTCTGCTCCTCCGACTCCTTCAACGAG
GACATCGCGGTCTTCGCCAAGCAGGTTCGCGCCGAAAAGCCACTTTTTTCCTCAAATCCAGAGCTGGACAATTTGATGATACAAGCAATACAAGTACTAA
GGTTTCATCTTTTGGAGTTAGAAAAGGTCCACGAACTGTGCGATAACTTCTGCCACCGATACATTAGCTGTTTGAAGGGGAAAATGCCCATCGACCTCGT
CATTGATGAAAGAGACGGCAGCTCCAAGTCAGATCATGAAGAACTTTCAGGCTCCTCCACAAATCTCGCTGACCATAACCCTTCTTCTTGGCGAGACCAC
GATGATGCAACCTCAACCCACTCAGCAGGCACCCCAGGGCCCTCCAGTGGGGGCCATGCTTCCCAGAGCGGAGACAACAGCAGTGAGCAAGGGGATGGTT
TAGACAACAGTGTAGCTTCACCTGGTACAGGTGACGATGATGATCCGGATAAGGACAAAAAACGCCAGAAGAAAAGAGGCATTTTCCCCAAAGTAGCAAC
AAATATCATGAGAGCATGGCTCTTCCAGCATCTCACACATCCGTACCCTTCCGAAGAGCAGAAGAAACAGTTAGCGCAAGACACAGGACTTACAATTCTC
CAAGTAAACAACTGGTTTATTAATGCCAGAAGAAGAATAGTACAGCCCATGATTGACCAGTCAAATCGAGCAGGTTTTCTTCTTGATCCTTCAGTGAGCC
AAGGAGCAGCATATAGTCCAGAGGGTCAGCCCATGGGGAGCTTTGTGTTGGATGGTCAGCAACACATGGGGATCCGGCCTGCAGGACCTATGAGTGGAAT
GGGCATGAATATGGGCATGGATGGGCAATGGCACTACATGTAACCTTCATCATGTAAAGCAATCGCAAAGCAAGGGGGAAGTTTGCAGAGCATGCCAGGG
GACTACGTTTCTCAGGGTGGTCCTATGGGAATGAGTATGGCACAGCCAAGTTACACTCCTCCCCAGATGACCCCACACCCTACTCAATTAAGACATGGAC
CCCCAATGCATTCATATTTGCCAAGCCATCCCCACCACCCAGCCATGATGATGCACGGAGGACCCCCTACCCACCCTGGAATGACTATGTCAGCACAGAG
CCCCACAATGTTAAATTCTGTAGATCCCAATGTTGGCGGACAGGTTATGGACATTCATGCCCAATAGTATAAGGGAACTCAAGGGAAAAGGAAACACACG
CAAAAACTATTTTAAGACTTTCTGAACTTTGACCAGATGTTGACACTTAATATGAAATTCCAGACAGCTGTGATTATTTTTTACTTTTGTCATTTTTCAT
CAAGCAACAGAGGACCAATGCAACAAGAACACAAATGTGAAATCATGGGCTGACTGAGACAATTCTGTCCATGTAAAGATCCTCTGGAAAAAGACTCCGA
GAGTTATAACTACTGTAGTATAAATATAGGAACTAAGTTAAACTTGTACATTTCTGTTGATCACGCCGTTATGTTGCCTCAAATAGTTTTAGAAGAGAAA
AAAAAATATATCCTTGTTTTCCACACTATGTGTGTTGTTCCCAAAAGAATGACTGTTTTGGTTCATCAGTGAATTCACCATCCAGGAGAGACTGTGGTAT
ATATTTTAAACCTGTTGGGCCAATGAGAAAAGAACCACACTGGAGATCATGATGAACTTTTGGCTGAACCTCATCACTCGAACTCCAGCTTCAAGAATGT
GTTTTCATGCCCGGCCTTTGTTCCTCCATAAATGTGTCCTTTAGTTTCAAACAGATCTTTATAGTTCGTGCTTCATAAGCCAATTCTTATTATTATTTTT
GGGGGACTCTTCTTCAAAGAGCTTGCCAATGAAGATTTAAAGACAGAGCAGGAGCTTCTTCCAGGAGTTCTGAGCCTTGGTTGTGGACAAAACAATCTTA
AGTTGGGCAGCTTTCCTCAACACAAAAAAAAGTTATTAATGGTCATTGAACCATAACTAGGACTTTATCAGAAACTCAAAGCTTGGGGGATAAAAAGGAG
CAAGAGAATACTGTAACAAACTTCGTACAGAGTTCGGTCTATTAATTGTTTCATGTTAGATATTCTATGTGTTTACCTCAATTGAAAAAAAAAAGAATGT
TTTTGCTAGTATCAGATCTGCTGTGGAATTGGTATTGTATGTCCATGAATTCTTCTTTTCTCAGCACGTGTTCCTCACTAGAAGAAAATGCTGTTACCTT
TAAGCTTTGTCAAATTTACATTAAAATACTTGTATGAGGACTGTGACGTTATGTTAAAAAAAAAAAGGTGTTAAGTCACAAAAAGCGGTAATAAATATTT
CATTTTTGA
  • refseq_MEIS2.F4 (forward primer)
  • refseq_MEIS2.R4 (reverse primer)
  • Single exon skipping

Frame 0

SRSPLPGCVSAVRRAMATTTSGFRHFVLPPPTR
AAKLRLFNKPGSSQPANTY*HSLISQREKESERE
RARESERE*ERASERERERGRDKIPTRKGGEEV
QFLQTIHFFFLIFLTAFFEQYFKERGSYYRYRG
GKAKKGGRGEEKIQEAETPRGVLLEEKNGSERFL
LFIIINHHSFTTLTFRALIDSWSGKKP*NTTVR
LHVGC*RAARNLQFGGLTIFFFFFFFFFSFFFF
PTEGKRRERGGKEDRRGGGGEGGGGGGGGGGGRS
GGGGRRGKKRKRRNITEKKILRCLDWAFFPP*K
IAYWRIGRSLFGLEKKKRNLQPRSLSYPDWDIK
YTTHPGVYWSAD*WRKGTMSCPITAGWTE*GFPL
PCTETLTRRGRSPRFTT*TTGRRSTPHSTTART
PRTPMSCRPVWDPLSTTP*SGTRTRSMGTRCFL
C*LWSLRSASWRPALPGNLEWLAETSAPPTPSTR
TSRSSPSRFAPKSHFFPQIQSWTI**YKQYKY*
GFIFWS*KRSTNCAITSATDTLAV*RGKCPSTS
SLMKETAAPSQIMKNFQAPPQISLTITLLLGETT
MMQPQPTQQAPQGPPVGAMLPRAETTAVSKGMV
*TTV*LHLVQVTMMIRIRTKNARRKEAFSPK*Q
QIS*EHGSSSISHIRTLPKSRRNS*RKTQDLQFS
K*TTGLLMPEEE*YSP*LTSQIEQVFFLILQ*A
KEQHIVQRVSPWGALCWMVSNTWGSGLQDL*VE
WA*IWAWMGNGTTCNLHHVKQSQSKGEVCRACQG
TTFLRVVLWE*VWHSQVTLLPR*PHTLLN*DMD
PQCIHICQAIPTTQP**CTEDPLPTLE*LCQHR
APQC*IL*IPMLADRLWTFMPNSIRELKGKGNTR
KNYFKTF*TLTRC*HLI*NSRQL*LFFTFVIFH
QATEDQCNKNTNVKSWAD*DNSVHVKILWKKTP
RVITTVV*I*ELS*TCTFLLITPLCCLK*F*KRK
KNISLFSTLCVLFPKE*LFWFISEFTIQERLWY
IF*TCWANEKRTTLEIMMNFWLNLITRTPASRM
CFHARPLFLHKCVL*FQTDLYSSCFISQFLLLFL
GDSSSKSLPMKI*RQSRSFFQEF*ALVVDKTIL
SWAAFLNTKKSY*WSLNHN*DFIRNSKLGG*KG
AREYCNKLRTEFGLLIVSC*IFYVFTSIEKKKNV
FASIRSAVELVLYVHEFFFSQHVFLTRRKCCYL
*ALSNLH*NTCMRTVTLC*KKKGVKSQKAVINI
SFL

Frame 1

PAPHSRDVSPPYDGLWPPRLPGSVISFSRRRPA
PPN*GSSISQAAANLPTPTDTHSSPRERKRARE
SERERASASESERASEKEREGETKYLPGKGGRKS
NFCKLFIFFS*FFSLLSLNNTLKREDRIIDTAG
AKLKKGGGGRKKFKKQKPLAEFYWKKKTGLKDS
SSSSSSTIIHSLP*HSGL*LTAGVAKSHETRQFG
YMWAADGPLVTFSSGA*QFFSSFSSFSFLSFFF
QLRGREEKEGERRTEEEEEGRGEEEEVEEEEED
QEEEEEEEKREKEEISQKKKFFVV*TGLFFPPKK
*HIGELGEVSLVWKKKKGIFSLDHFLIRTGILN
IRHIQEFIGAQTDGAKVR*AAPLRRDGRSRGSR
FHVRRPSRAAADPPGSPPEPRAAAPRHTALRRAR
PAPQCHAGQYGIRCQRRLEAGQGRDLWAPVVSS
VSSGL*EVRAGDLHSPGTWSGWRRRLLLRLLQR
GHRGLRQAGSRRKATFFLKSRAGQFDDTSNTSTK
VSSFGVRKGPRTVR*LLPPIH*LFEGENAHRPR
H**KRRQLQVRS*RTFRLLHKSR*P*PFFLARP
R*CNLNPLSRHPRALQWGPCFPERRQQQ*ARGWF
RQQCSFTWYR*R**SG*GQKTPEEKRHFPQSSN
KYHESMALPASHTSVPFRRAEETVSARHRTYNS
PSKQLVY*CQKKNSTAHD*PVKSSRFSS*SFSEP
RSSI*SRGSAHGELCVGWSATHGDPACRTYEWN
GHEYGHGWAMALHVTFIM*SNRKARGKFAEHAR
GLRFSGWSYGNEYGTAKLHSSPDDPTPYSIKTWT
PNAFIFAKPSPPPSHDDARRTPYPPWNDYVSTE
PHNVKFCRSQCWRTGYGHSCPIV*GNSREKETH
AKTILRLSEL*PDVDT*YEIPDSCDYFLLLSFFI
KQQRTNATRTQM*NHGLTETILSM*RSSGKRLR
EL*LL*YKYRN*VKLVHFC*SRRYVASNSFRRE
KKIYPCFPHYVCCSQKNDCFGSSVNSPSRRDCGI
YFKPVGPMRKEPHWRS**TFG*TSSLELQLQEC
VFMPGLCSSINVSFSFKQIFIVRAS*ANSYYYF
WGTLLQRACQ*RFKDRAGASSRSSEPWLWTKQS*
VGQLSSTQKKVINGH*TITRTLSETQSLGDKKE
QENTVTNFVQSSVY*LFHVRYSMCLPQLKKKRM
FLLVSDLLWNWYCMSMNSSFLSTCSSLEENAVTF
KLCQIYIKILV*GL*RYVKKKKVLSHKKR**IF
HF*

Frame 2

PLPTPGMCLRRTTGYGHHDFRVPSFRSPAADPR
RQTEALQ*ARQQPTCQHLLTLTHLPERERERER
ASARERARVRASERARKRERERQNTYQERGGGS
PIFANYSFFFLDFSHCFL*TIL*RERIVL*IPRG
QS*KRGEGGGKNSRSRNPSRSFTGRKKRV*KIP
PLHHHQPSFIHYLDIPGFD*QLEWQKAMKHDSS
VTCGLLTGRS*PSVRGLDNFFLLFLLFLFFLFFS
N*GEEKRKRGKGGPKRRRRGGGRRRRWRRRRKI
RRRRKKRKKEKKKKYHRKKNSSLSRLGFFSPLK
NSILENWEKSLWFGKKKKESSA*ITFLSGLGY*I
YDTSRSLLERRLMAQRYDELPHYGGMDGVGVPA
SMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAH
APHPNVMPASMGSAVNDALKRDKDAIYGHPLFPL
LALVFEKCELATCTPREPGVAGGDVCSSDSFNE
DIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVL
RFHLLELEKVHELCDNFCHRYISCLKGKMPIDLV
IDERDGSSKSDHEELSGSSTNLADHNPSSWRDH
DDATSTHSAGTPGPSSGGHASQSGDNSSEQGDG
LDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVAT
NIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTIL
QVNNWFINARRRIVQPMIDQSNRAGFLLDPSVS
QGAAYSPEGQPMGSFVLDGQQHMGIRPAGPMSGM
GMNMGMDGQWHYM*PSSCKAIAKQGGSLQSMPG
DYVSQGGPMGMSMAQPSYTPPQMTPHPTQLRHG
PPMHSYLPSHPHHPAMMMHGGPPTHPGMTMSAQS
PTMLNSVDPNVGGQVMDIHAQ*YKGTQGKRKHT
QKLF*DFLNFDQMLTLNMKFQTAVIIFYFCHFS
SSNRGPMQQEHKCEIMG*LRQFCPCKDPLEKDSE
SYNYCSINIGTKLNLYISVDHAVMLPQIVLEEK
KKYILVFHTMCVVPKRMTVLVHQ*IHHPGETVV
YILNLLGQ*EKNHTGDHDELLAEPHHSNSSFKNV
FSCPAFVPP*MCPLVSNRSL*FVLHKPILIIIF
GGLFFKELANEDLKTEQELLPGVLSLGCGQNNL
KLGSFPQHKKKLLMVIEP*LGLYQKLKAWGIKRS
KRIL*QTSYRVRSINCFMLDILCVYLN*KKKEC
FC*YQICCGIGIVCP*ILLFSARVPH*KKMLLP
LSFVKFTLKYLYEDCDVMLKKKRC*VTKSGNKYF
IF

Sequence NM_002399

TTGGCTACATCGGACCCAGATGACTGCCTCCTCACTTCCTCCCTCCCGATTCCGCCGCGGCCCCCAAAGACTCTCGGGGTGGCCCCTTGTCCGCACCGCT
TGGAGGGAGTGTGCTCTGAGTTAAGCTGGTCTCTTCTGGTCCTGGAAAAAAATGAGTATTGACAAGGTTGCTGGATCTGCGCAGAAAAGAAAGTGCCACT
TAATAAAAAATTTAGCCCGGCAGTGGTACCGTCTGCAGAGCTTGCTGCCCTTGGACGTTAGCAGGAAGCCTTCGGGGTGCTGTAATCGGCGGGCAGAGGA
GAGGGAGGCCGCGGAATTAAAAGGAACAAAAGCTAGAGCGCCATGCCAAACGTCCCCGGCAAGACCCAGTTAGGCAGGAGCCGGGAGTGATGGGAAAATG
AACTAGAATACGATGAGCTGCCCCATTACGGCGGGATGGACGGAGTAGGGGTTCCCGCTTCCATGTACGGAGACCCTCACGCGCCGCGGCCGATCCCCCC
GGTTCACCACCTGAACCACGGGCCGCCGCTCCACGCCACACAGCACTACGGCGCGCACGCCCCGCACCCCAATGTCATGCCGGCCAGTATGGGATCCGCT
GTCAACGACGCCTTGAAGCGGGACAAGGACGCGATCTATGGGCACCCGTTGTTTCCTCTGTTAGCTCTGGTCTTTGAGAAGTGCGAGCTGGCGACCTGCA
CTCCCCGGGAACCTGGAGTGGCTGGCGGAGACGTCTGCTCCTCCGACTCCTTCAACGAGGACATCGCGGTCTTCGCCAAGCAGGTTCGCGCCGAAAAGCC
ACTTTTTTCCTCAAATCCAGAGCTGGACAATTTGATGATACAAGCAATACAAGTACTAAGGTTTCATCTTTTGGAGTTAGAAAAGGTCCACGAACTGTGC
GATAACTTCTGCCACCGATACATTAGCTGTTTGAAGGGGAAAATGCCCATCGACCTCGTCATTGATGAAAGAGACGGCAGCTCCAAGTCAGATCATGAAG
AACTTTCAGGCTCCTCCACAAATCTCGCTGACCATAACCCTTCTTCTTGGCGAGACCACGATGATGCAACCTCAACCCACTCAGCAGGCACCCCAGGGCC
CTCCAGTGGGGGCCATGCTTCCCAGAGCGGAGACAACAGCAGTGAGCAAGGGGATGGTTTAGACAACAGTGTAGCTTCACCTGGTACAGGTGACGATGAT
GATCCGGATAAGGACAAAAAACGCCAGAAGAAAAGAGGCATTTTCCCCAAAGTAGCAACAAATATCATGAGAGCATGGCTCTTCCAGCATCTCACACATC
CGTACCCTTCCGAAGAGCAGAAGAAACAGTTAGCGCAAGACACAGGACTTACAATTCTCCAAGTAAACAACTGGTTTATTAATGCCAGAAGAAGAATAGT
ACAGCCCATGATTGACCAGTCAAATCGAGCAGTGAGCCAAGGAGCAGCATATAGTCCAGAGGGTCAGCCCATGGGGAGCTTTGTGTTGGATGGTCAGCAA
CACATGGGGATCCGGCCTGCAGGACCTATGAGTGGAATGGGCATGAATATGGGCATGGATGGGCAATGGCACTACATGTAACCTTCATCATGTAAAGCAA
TCGCAAAGCAAGGGGGAAGTTTGCAGAGCATGCCAGGGGACTACGTTTCTCAGGGTGGTCCTATGGGAATGAGTATGGCACAGCCAAGTTACACTCCTCC
CCAGATGACCCCACACCCTACTCAATTAAGACATGGACCCCCAATGCATTCATATTTGCCAAGCCATCCCCACCACCCAGCCATGATGATGCACGGAGGA
CCCCCTACCCACCCTGGAATGACTATGTCAGCACAGAGCCCCACAATGTTAAATTCTGTAGATCCCAATGTTGGCGGACAGGTTATGGACATTCATGCCC
AATAGTATAAGGGAACTCAAGGGAAAAGGAAACACACGCAAAAACTATTTTAAGACTTTCTGAACTTTGACCAGATGTTGACACTTAATATGAAATTCCA
GACAGCTGTGATTATTTTTTACTTTTGTCATTTTTCATCAAGCAACAGAGGACCAATGCAACAAGAACACAAATGTGAAATCATGGGCTGACTGAGACAA
TTCTGTCCATGTAAAGATCCTCTGGAAAAAGACTCCGAGAGTTATAACTACTGTAGTATAAATATAGGAACTAAGTTAAACTTGTACATTTCTGTTGATC
ACGCCGTTATGTTGCCTCAAATAGTTTTAGAAGAGAAAAAAAAATATATCCTTGTTTTCCACACTATGTGTGTTGTTCCCAAAAGAATGACTGTTTTGGT
TCATCAGTGAATTCACCATCCAGGAGAGACTGTGGTATATATTTTAAACCTGTTGGGCCAATGAGAAAAGAACCACACTGGAGATCATGATGAACTTTTG
GCTGAACCTCATCACTCGAACTCCAGCTTCAAGAATGTGTTTTCATGCCCGGCCTTTGTTCCTCCATAAATGTGTCCTTTAGTTTCAAACAGATCTTTAT
AGTTCGTGCTTCATAAGCCAATTCTTATTATTATTTTTGGGGGACTCTTCTTCAAAGAGCTTGCCAATGAAGATTTAAAGACAGAGCAGGAGCTTCTTCC
AGGAGTTCTGAGCCTTGGTTGTGGACAAAACAATCTTAAGTTGGGCAGCTTTCCTCAACACAAAAAAAAGTTATTAATGGTCATTGAACCATAACTAGGA
CTTTATCAGAAACTCAAAGCTTGGGGGATAAAAAGGAGCAAGAGAATACTGTAACAAACTTCGTACAGAGTTCGGTCTATTAATTGTTTCATGTTAGATA
TTCTATGTGTTTACCTCAATTGAAAAAAAAAAGAATGTTTTTGCTAGTATCAGATCTGCTGTGGAATTGGTATTGTATGTCCATGAATTCTTCTTTTCTC
AGCACGTGTTCCTCACTAGAAGAAAATGCTGTTACCTTTAAGCTTTGTCAAATTTACATTAAAATACTTGTATGAGGACTGTGACGTTATGTTAAAAAAA
AAAAGGTGTTAAGTCACAAAAAGCGGTAATAAATATTTCATTTTTGA
  • refseq_MEIS2.F4 (forward primer)
  • refseq_MEIS2.R4 (reverse primer)
  • Single exon skipping

Frame 0

LATSDPDDCLLTSSLPIPPRPPKTLGVAPCPHR
LEGVCSELSWSLLVLEKNEY*QGCWICAEKKVPL
NKKFSPAVVPSAELAALGR*QEAFGVL*SAGRG
EGGRGIKRNKS*SAMPNVPGKTQLGRSRE*WEN
ELEYDELPHYGGMDGVGVPASMYGDPHAPRPIPP
VHHLNHGPPLHATQHYGAHAPHPNVMPASMGSA
VNDALKRDKDAIYGHPLFPLLALVFEKCELATC
TPREPGVAGGDVCSSDSFNEDIAVFAKQVRAEKP
LFSSNPELDNLMIQAIQVLRFHLLELEKVHELC
DNFCHRYISCLKGKMPIDLVIDERDGSSKSDHE
ELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGP
SSGGHASQSGDNSSEQGDGLDNSVASPGTGDDD
DPDKDKKRQKKRGIFPKVATNIMRAWLFQHLTH
PYPSEEQKKQLAQDTGLTILQVNNWFINARRRIV
QPMIDQSNRAVSQGAAYSPEGQPMGSFVLDGQQ
HMGIRPAGPMSGMGMNMGMDGQWHYM*PSSCKA
IAKQGGSLQSMPGDYVSQGGPMGMSMAQPSYTPP
QMTPHPTQLRHGPPMHSYLPSHPHHPAMMMHGG
PPTHPGMTMSAQSPTMLNSVDPNVGGQVMDIHA
Q*YKGTQGKRKHTQKLF*DFLNFDQMLTLNMKFQ
TAVIIFYFCHFSSSNRGPMQQEHKCEIMG*LRQ
FCPCKDPLEKDSESYNYCSINIGTKLNLYISVD
HAVMLPQIVLEEKKKYILVFHTMCVVPKRMTVLV
HQ*IHHPGETVVYILNLLGQ*EKNHTGDHDELL
AEPHHSNSSFKNVFSCPAFVPP*MCPLVSNRSL
*FVLHKPILIIIFGGLFFKELANEDLKTEQELLP
GVLSLGCGQNNLKLGSFPQHKKKLLMVIEP*LG
LYQKLKAWGIKRSKRIL*QTSYRVRSINCFMLD
ILCVYLN*KKKECFC*YQICCGIGIVCP*ILLFS
ARVPH*KKMLLPLSFVKFTLKYLYEDCDVMLKK
KRC*VTKSGNKYFIF

Frame 1

WLHRTQMTASSLPPSRFRRGPQRLSGWPLVRTA
WRECALS*AGLFWSWKKMSIDKVAGSAQKRKCH
LIKNLARQWYRLQSLLPLDVSRKPSGCCNRRAEE
REAAELKGTKARAPCQTSPARPS*AGAGSDGKM
N*NTMSCPITAGWTE*GFPLPCTETLTRRGRSP
RFTT*TTGRRSTPHSTTARTPRTPMSCRPVWDPL
STTP*SGTRTRSMGTRCFLC*LWSLRSASWRPA
LPGNLEWLAETSAPPTPSTRTSRSSPSRFAPKS
HFFPQIQSWTI**YKQYKY*GFIFWS*KRSTNCA
ITSATDTLAV*RGKCPSTSSLMKETAAPSQIMK
NFQAPPQISLTITLLLGETTMMQPQPTQQAPQG
PPVGAMLPRAETTAVSKGMV*TTV*LHLVQVTMM
IRIRTKNARRKEAFSPK*QQIS*EHGSSSISHI
RTLPKSRRNS*RKTQDLQFSK*TTGLLMPEEE*
YSP*LTSQIEQ*AKEQHIVQRVSPWGALCWMVSN
TWGSGLQDL*VEWA*IWAWMGNGTTCNLHHVKQ
SQSKGEVCRACQGTTFLRVVLWE*VWHSQVTLL
PR*PHTLLN*DMDPQCIHICQAIPTTQP**CTED
PLPTLE*LCQHRAPQC*IL*IPMLADRLWTFMP
NSIRELKGKGNTRKNYFKTF*TLTRC*HLI*NS
RQL*LFFTFVIFHQATEDQCNKNTNVKSWAD*DN
SVHVKILWKKTPRVITTVV*I*ELS*TCTFLLI
TPLCCLK*F*KRKKNISLFSTLCVLFPKE*LFW
FISEFTIQERLWYIF*TCWANEKRTTLEIMMNFW
LNLITRTPASRMCFHARPLFLHKCVL*FQTDLY
SSCFISQFLLLFLGDSSSKSLPMKI*RQSRSFF
QEF*ALVVDKTILSWAAFLNTKKSY*WSLNHN*D
FIRNSKLGG*KGAREYCNKLRTEFGLLIVSC*I
FYVFTSIEKKKNVFASIRSAVELVLYVHEFFFS
QHVFLTRRKCCYL*ALSNLH*NTCMRTVTLC*KK
KGVKSQKAVINISFL

Frame 2

GYIGPR*LPPHFLPPDSAAAPKDSRGGPLSAPL
GGSVL*VKLVSSGPGKK*VLTRLLDLRRKESAT
**KI*PGSGTVCRACCPWTLAGSLRGAVIGGQR
RGRPRN*KEQKLERHAKRPRQDPVRQEPGVMGK*
TRIR*AAPLRRDGRSRGSRFHVRRPSRAAADPP
GSPPEPRAAAPRHTALRRARPAPQCHAGQYGIR
CQRRLEAGQGRDLWAPVVSSVSSGL*EVRAGDLH
SPGTWSGWRRRLLLRLLQRGHRGLRQAGSRRKA
TFFLKSRAGQFDDTSNTSTKVSSFGVRKGPRTV
R*LLPPIH*LFEGENAHRPRH**KRRQLQVRS*R
TFRLLHKSR*P*PFFLARPR*CNLNPLSRHPRA
LQWGPCFPERRQQQ*ARGWFRQQCSFTWYR*R*
*SG*GQKTPEEKRHFPQSSNKYHESMALPASHTS
VPFRRAEETVSARHRTYNSPSKQLVY*CQKKNS
TAHD*PVKSSSEPRSSI*SRGSAHGELCVGWSA
THGDPACRTYEWNGHEYGHGWAMALHVTFIM*SN
RKARGKFAEHARGLRFSGWSYGNEYGTAKLHSS
PDDPTPYSIKTWTPNAFIFAKPSPPPSHDDARR
TPYPPWNDYVSTEPHNVKFCRSQCWRTGYGHSCP
IV*GNSREKETHAKTILRLSEL*PDVDT*YEIP
DSCDYFLLLSFFIKQQRTNATRTQM*NHGLTET
ILSM*RSSGKRLREL*LL*YKYRN*VKLVHFC*S
RRYVASNSFRREKKIYPCFPHYVCCSQKNDCFG
SSVNSPSRRDCGIYFKPVGPMRKEPHWRS**TF
G*TSSLELQLQECVFMPGLCSSINVSFSFKQIFI
VRAS*ANSYYYFWGTLLQRACQ*RFKDRAGASS
RSSEPWLWTKQS*VGQLSSTQKKVINGH*TITR
TLSETQSLGDKKEQENTVTNFVQSSVY*LFHVRY
SMCLPQLKKKRMFLLVSDLLWNWYCMSMNSSFL
STCSSLEENAVTFKLCQIYIKILV*GL*RYVKK
KKVLSHKKR**IFHF*

Sequence NM_020149

TCCCGCTCCCCACTCCCGGGATGTGTCTCCGCCGTACGACGGGCTATGGCCACCACGACTTCCGGGTTCCGTCATTTCGTTCTCCCGCCGCCGACCCGCG
CCGCCAAACTGAGGCTCTTCAATAAGCCAGGCAGCAGCCAACCTGCCAACACCTACTGACACTCACTCATCTCCCAGAGAGAGAAAGAGAGCGAGAGAGA
GCGAGCGCGAGAGAGCGAGCGCGAGTGAGAGCGAGCGAGCGAGCGAGAAAGAGAGAGAGGGAGAGACAAAATACCTACCAGGAAAGGGGGGGAGGAAGTC
CAATTTTTGCAAACTATTCATTTTTTTTTCTTGATTTTTCTCACTGCTTTCTTTGAACAATACTTTAAAGAGAGAGGATCGTATTATAGATACCGCGGGG
GCAAAGCTAAAAAAGGGGGGAGGGGGGAGGAAAAAATTCAAGAAGCAGAAACCCCTCGCGGAGTTTTACTGGAAGAAAAAAACGGGTCTGAAAGATTCCT
CCTCTTCATCATCATCAACCATCATTCATTCACTACCTTGACATTCCGGGCTTTGATTGACAGCTGGAGTGGCAAAAAGCCATGAAACACGACAGTTCGG
TTACATGTGGGCTGCTGACGGGCCGCTCGTAACCTTCAGTTCGGGGGCTTGACAATTTTTTTCTTCTTTTTCTTCTTTTTCTTTTCTTTCTTTTTTTTTC
CAACTGAGGGGAAGAGAAGAGAAAGAGGGGGAAAGGAGGACCGAAGAGGAGGAGGAGGGGAGGGGGGAGGAGGAGGAGGTGGAGGAGGAGGAGGAAGATC
AGGAGGAGGAGGAAGAAGAGGAAAAAAGAGAAAAAGAAGAAATATCACAGAAAAAAAAATTCTTCGTTGTCTAGACTGGGCTTTTTTTCCCCCCTAAAAA
ATAGCATATTGGAGAATTGGGAGAAGTCTCTTTGGTTTGGAAAAAAAAAAAAGGAATCTTCAGCCTAGATCACTTTCTTATCCGGACTGGGATATTAAAT
ATACGACACATCCAGGAGTTTATTGGAGCGCAGACTGATGGCGCAAAGGTACGATGAGCTGCCCCATTACGGCGGGATGGACGGAGTAGGGGTTCCCGCT
TCCATGTACGGAGACCCTCACGCGCCGCGGCCGATCCCCCCGGTTCACCACCTGAACCACGGGCCGCCGCTCCACGCCACACAGCACTACGGCGCGCACG
CCCCGCACCCCAATGTCATGCCGGCCAGTATGGGATCCGCTGTCAACGACGCCTTGAAGCGGGACAAGGACGCGATCTATGGGCACCCGTTGTTTCCTCT
GTTAGCTCTGGTCTTTGAGAAGTGCGAGCTGGCGACCTGCACTCCCCGGGAACCTGGAGTGGCTGGCGGAGACGTCTGCTCCTCCGACTCCTTCAACGAG
GACATCGCGGTCTTCGCCAAGCAGGTTCGCGCCGAAAAGCCACTTTTTTCCTCAAATCCAGAGCTGGACAATTTGATGATACAAGCAATACAAGTACTAA
GGTTTCATCTTTTGGAGTTAGAAAAGGTCCACGAACTGTGCGATAACTTCTGCCACCGATACATTAGCTGTTTGAAGGGGAAAATGCCCATCGACCTCGT
CATTGATGAAAGAGACGGCAGCTCCAAGTCAGATCATGAAGAACTTTCAGGCTCCTCCACAAATCTCGCTGACCATAACCCTTCTTCTTGGCGAGACCAC
GATGATGCAACCTCAACCCACTCAGCAGGCACCCCAGGGCCCTCCAGTGGGGGCCATGCTTCCCAGAGCGGAGACAACAGCAGTGAGCAAGGGGATGGTT
TAGACAACAGTGTAGCTTCACCTGGTACAGGTGACGATGATGATCCGGATAAGGACAAAAAACGCCAGAAGAAAAGAGGCATTTTCCCCAAAGTAGCAAC
AAATATCATGAGAGCATGGCTCTTCCAGCATCTCACAGTTTATTAATGCCAGAAGAAGAATAGTACAGCCCATGATTGACCAGTCAAATCGAGCAGTGAG
CCAAGGAGCAGCATATAGTCCAGAGGGTCAGCCCATGGGGAGCTTTGTGTTGGATGGTCAGCAACACATGGGGATCCGGCCTGCAGGACCTATGAGTGGA
ATGGGCATGAATATGGGCATGGATGGGCAATGGCACTACATGTAACCTTCATCATGTAAAGCAATCGCAAAGCAAGGGGGAAGTTTGCAGAGCATGCCAG
GGGACTACGTTTCTCAGGGTGGTCCTATGGGAATGAGTATGGCACAGCCAAGTTACACTCCTCCCCAGATGACCCCACACCCTACTCAATTAAGACATGG
ACCCCCAATGCATTCATATTTGCCAAGCCATCCCCACCACCCAGCCATGATGATGCACGGAGGACCCCCTACCCACCCTGGAATGACTATGTCAGCACAG
AGCCCCACAATGTTAAATTCTGTAGATCCCAATGTTGGCGGACAGGTTATGGACATTCATGCCCAATAGTATAAGGGAACTCAAGGGAAAAGGAAACACA
CGCAAAAACTATTTTAAGACTTTCTGAACTTTGACCAGATGTTGACACTTAATATGAAATTCCAGACAGCTGTGATTATTTTTTACTTTTGTCATTTTTC
ATCAAGCAACAGAGGACCAATGCAACAAGAACACAAATGTGAAATCATGGGCTGACTGAGACAATTCTGTCCATGTAAAGATCCTCTGGAAAAAGACTCC
GAGAGTTATAACTACTGTAGTATAAATATAGGAACTAAGTTAAACTTGTACATTTCTGTTGATCACGCCGTTATGTTGCCTCAAATAGTTTTAGAAGAGA
AAAAAAAATATATCCTTGTTTTCCACACTATGTGTGTTGTTCCCAAAAGAATGACTGTTTTGGTTCATCAGTGAATTCACCATCCAGGAGAGACTGTGGT
ATATATTTTAAACCTGTTGGGCCAATGAGAAAAGAACCACACTGGAGATCATGATGAACTTTTGGCTGAACCTCATCACTCGAACTCCAGCTTCAAGAAT
GTGTTTTCATGCCCGGCCTTTGTTCCTCCATAAATGTGTCCTTTAGTTTCAAACAGATCTTTATAGTTCGTGCTTCATAAGCCAATTCTTATTATTATTT
TTGGGGGACTCTTCTTCAAAGAGCTTGCCAATGAAGATTTAAAGACAGAGCAGGAGCTTCTTCCAGGAGTTCTGAGCCTTGGTTGTGGACAAAACAATCT
TAAGTTGGGCAGCTTTCCTCAACACAAAAAAAAGTTATTAATGGTCATTGAACCATAACTAGGACTTTATCAGAAACTCAAAGCTTGGGGGATAAAAAGG
AGCAAGAGAATACTGTAACAAACTTCGTACAGAGTTCGGTCTATTAATTGTTTCATGTTAGATATTCTATGTGTTTACCTCAATTGAAAAAAAAAAGAAT
GTTTTTGCTAGTATCAGATCTGCTGTGGAATTGGTATTGTATGTCCATGAATTCTTCTTTTCTCAGCACGTGTTCCTCACTAGAAGAAAATGCTGTTACC
TTTAAGCTTTGTCAAATTTACATTAAAATACTTGTATGAGGACTGTGACGTTATGTTAAAAAAAAAAAGGTGTTAAGTCACAAAAAGCGGTAATAAATAT
TTCATTTTTGA
  • refseq_MEIS2.F4 (forward primer)
  • refseq_MEIS2.R4 (reverse primer)
  • Single exon skipping

Frame 0

SRSPLPGCVSAVRRAMATTTSGFRHFVLPPPTR
AAKLRLFNKPGSSQPANTY*HSLISQREKESERE
RARESERE*ERASERERERGRDKIPTRKGGEEV
QFLQTIHFFFLIFLTAFFEQYFKERGSYYRYRG
GKAKKGGRGEEKIQEAETPRGVLLEEKNGSERFL
LFIIINHHSFTTLTFRALIDSWSGKKP*NTTVR
LHVGC*RAARNLQFGGLTIFFFFFFFFFSFFFF
PTEGKRRERGGKEDRRGGGGEGGGGGGGGGGGRS
GGGGRRGKKRKRRNITEKKILRCLDWAFFPP*K
IAYWRIGRSLFGLEKKKRNLQPRSLSYPDWDIK
YTTHPGVYWSAD*WRKGTMSCPITAGWTE*GFPL
PCTETLTRRGRSPRFTT*TTGRRSTPHSTTART
PRTPMSCRPVWDPLSTTP*SGTRTRSMGTRCFL
C*LWSLRSASWRPALPGNLEWLAETSAPPTPSTR
TSRSSPSRFAPKSHFFPQIQSWTI**YKQYKY*
GFIFWS*KRSTNCAITSATDTLAV*RGKCPSTS
SLMKETAAPSQIMKNFQAPPQISLTITLLLGETT
MMQPQPTQQAPQGPPVGAMLPRAETTAVSKGMV
*TTV*LHLVQVTMMIRIRTKNARRKEAFSPK*Q
QIS*EHGSSSISQFINARRRIVQPMIDQSNRAVS
QGAAYSPEGQPMGSFVLDGQQHMGIRPAGPMSG
MGMNMGMDGQWHYM*PSSCKAIAKQGGSLQSMP
GDYVSQGGPMGMSMAQPSYTPPQMTPHPTQLRHG
PPMHSYLPSHPHHPAMMMHGGPPTHPGMTMSAQ
SPTMLNSVDPNVGGQVMDIHAQ*YKGTQGKRKH
TQKLF*DFLNFDQMLTLNMKFQTAVIIFYFCHFS
SSNRGPMQQEHKCEIMG*LRQFCPCKDPLEKDS
ESYNYCSINIGTKLNLYISVDHAVMLPQIVLEE
KKKYILVFHTMCVVPKRMTVLVHQ*IHHPGETVV
YILNLLGQ*EKNHTGDHDELLAEPHHSNSSFKN
VFSCPAFVPP*MCPLVSNRSL*FVLHKPILIII
FGGLFFKELANEDLKTEQELLPGVLSLGCGQNNL
KLGSFPQHKKKLLMVIEP*LGLYQKLKAWGIKR
SKRIL*QTSYRVRSINCFMLDILCVYLN*KKKE
CFC*YQICCGIGIVCP*ILLFSARVPH*KKMLLP
LSFVKFTLKYLYEDCDVMLKKKRC*VTKSGNKY
FIF

Frame 1

PAPHSRDVSPPYDGLWPPRLPGSVISFSRRRPA
PPN*GSSISQAAANLPTPTDTHSSPRERKRARE
SERERASASESERASEKEREGETKYLPGKGGRKS
NFCKLFIFFS*FFSLLSLNNTLKREDRIIDTAG
AKLKKGGGGRKKFKKQKPLAEFYWKKKTGLKDS
SSSSSSTIIHSLP*HSGL*LTAGVAKSHETRQFG
YMWAADGPLVTFSSGA*QFFSSFSSFSFLSFFF
QLRGREEKEGERRTEEEEEGRGEEEEVEEEEED
QEEEEEEEKREKEEISQKKKFFVV*TGLFFPPKK
*HIGELGEVSLVWKKKKGIFSLDHFLIRTGILN
IRHIQEFIGAQTDGAKVR*AAPLRRDGRSRGSR
FHVRRPSRAAADPPGSPPEPRAAAPRHTALRRAR
PAPQCHAGQYGIRCQRRLEAGQGRDLWAPVVSS
VSSGL*EVRAGDLHSPGTWSGWRRRLLLRLLQR
GHRGLRQAGSRRKATFFLKSRAGQFDDTSNTSTK
VSSFGVRKGPRTVR*LLPPIH*LFEGENAHRPR
H**KRRQLQVRS*RTFRLLHKSR*P*PFFLARP
R*CNLNPLSRHPRALQWGPCFPERRQQQ*ARGWF
RQQCSFTWYR*R**SG*GQKTPEEKRHFPQSSN
KYHESMALPASHSLLMPEEE*YSP*LTSQIEQ*
AKEQHIVQRVSPWGALCWMVSNTWGSGLQDL*VE
WA*IWAWMGNGTTCNLHHVKQSQSKGEVCRACQ
GTTFLRVVLWE*VWHSQVTLLPR*PHTLLN*DM
DPQCIHICQAIPTTQP**CTEDPLPTLE*LCQHR
APQC*IL*IPMLADRLWTFMPNSIRELKGKGNT
RKNYFKTF*TLTRC*HLI*NSRQL*LFFTFVIF
HQATEDQCNKNTNVKSWAD*DNSVHVKILWKKTP
RVITTVV*I*ELS*TCTFLLITPLCCLK*F*KR
KKNISLFSTLCVLFPKE*LFWFISEFTIQERLW
YIF*TCWANEKRTTLEIMMNFWLNLITRTPASRM
CFHARPLFLHKCVL*FQTDLYSSCFISQFLLLF
LGDSSSKSLPMKI*RQSRSFFQEF*ALVVDKTI
LSWAAFLNTKKSY*WSLNHN*DFIRNSKLGG*KG
AREYCNKLRTEFGLLIVSC*IFYVFTSIEKKKN
VFASIRSAVELVLYVHEFFFSQHVFLTRRKCCY
L*ALSNLH*NTCMRTVTLC*KKKGVKSQKAVINI
SFL

Frame 2

PLPTPGMCLRRTTGYGHHDFRVPSFRSPAADPR
RQTEALQ*ARQQPTCQHLLTLTHLPERERERER
ASARERARVRASERARKRERERQNTYQERGGGS
PIFANYSFFFLDFSHCFL*TIL*RERIVL*IPRG
QS*KRGEGGGKNSRSRNPSRSFTGRKKRV*KIP
PLHHHQPSFIHYLDIPGFD*QLEWQKAMKHDSS
VTCGLLTGRS*PSVRGLDNFFLLFLLFLFFLFFS
N*GEEKRKRGKGGPKRRRRGGGRRRRWRRRRKI
RRRRKKRKKEKKKKYHRKKNSSLSRLGFFSPLK
NSILENWEKSLWFGKKKKESSA*ITFLSGLGY*I
YDTSRSLLERRLMAQRYDELPHYGGMDGVGVPA
SMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAH
APHPNVMPASMGSAVNDALKRDKDAIYGHPLFPL
LALVFEKCELATCTPREPGVAGGDVCSSDSFNE
DIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVL
RFHLLELEKVHELCDNFCHRYISCLKGKMPIDLV
IDERDGSSKSDHEELSGSSTNLADHNPSSWRDH
DDATSTHSAGTPGPSSGGHASQSGDNSSEQGDG
LDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVAT
NIMRAWLFQHLTVY*CQKKNSTAHD*PVKSSSE
PRSSI*SRGSAHGELCVGWSATHGDPACRTYEW
NGHEYGHGWAMALHVTFIM*SNRKARGKFAEHAR
GLRFSGWSYGNEYGTAKLHSSPDDPTPYSIKTW
TPNAFIFAKPSPPPSHDDARRTPYPPWNDYVST
EPHNVKFCRSQCWRTGYGHSCPIV*GNSREKETH
AKTILRLSEL*PDVDT*YEIPDSCDYFLLLSFF
IKQQRTNATRTQM*NHGLTETILSM*RSSGKRL
REL*LL*YKYRN*VKLVHFC*SRRYVASNSFRRE
KKIYPCFPHYVCCSQKNDCFGSSVNSPSRRDCG
IYFKPVGPMRKEPHWRS**TFG*TSSLELQLQE
CVFMPGLCSSINVSFSFKQIFIVRAS*ANSYYYF
WGTLLQRACQ*RFKDRAGASSRSSEPWLWTKQS
*VGQLSSTQKKVINGH*TITRTLSETQSLGDKK
EQENTVTNFVQSSVY*LFHVRYSMCLPQLKKKRM
FLLVSDLLWNWYCMSMNSSFLSTCSSLEENAVT
FKLCQIYIKILV*GL*RYVKKKKVLSHKKR**I
FHF*

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