Sequences - Rnomics 📊 Palace

        ☰
    
        Rnomics 📊 Palace
    
                       Back to Rnomics Platform
            
                       Open Session

1 warning:

Access restricted to public data.
Please sign in at Rnomics Platform to access your data.

Navigation

Home

Sequences

Sequence NM_182961

CCCGGGCAGTGGAAACCGTGGGCAAAAGTTAGCTGGCAGGACAGCGCAGCTCCTCCAGGCAGCGGAGGCAGCGCGTCCCGGCTCTCAGGGACATTTCCTT CCCACCTCGACCCCCGGGAGGTGGTCCCGGTATAAAGGCTCGCTGAGCGGGTGGGTCACAGCACAGCTTTGCAGCTGCGGAGAAACGCCCAAGGCCGTGC ATCTCCAGGAGGGCGGCTGGGCTCCCGCAGTCCTGCAGACCGCGCCCGATCCCGGCGACAGGGCGGGCGGACAGCCGCGCATCCCCGGGGTCCCGCCGAG CCTGGGCGCAGAGAGCCGGGAGGAAGCGTTCGCTCGCTTCGCCTTGCTGCTGGGAAACTGAACGAGGCCGAGAGAGAAGGTTCTTGAGTTCATGTAAGAG GACAGTCTTAAAACGGAAGAAGAAAAAGAAGCAGTTCAGTCTTTGGGAGAGCTGCCTCCTTGTTGAGTGCTGCAAAGGCCTGGAATTCATTTATGACAGA ATAGATCTAGAAAAGTCCAAGCATGTTTTCTAGAGTGGTGTAGCCCTGTGCTGCCTCCAGTGAAGAGTCTCTTGGTGTTGGCTTCGTGCTTCCGGAGGGA CCATGGCAACCTCCAGAGGGGCCTCCCGGTGTCCTCGGGATATCGCCAATGTGATGCAGAGGCTGCAAGATGAGCAAGAGATAGTACAAAAACGAACTTT CACAAAATGGATCAACTCTCATCTGGCCAAGCGGAAACCTCCAATGGTGGTGGACGATCTTTTTGAAGACATGAAAGATGGTGTTAAACTGCTTGCCCTT CTGGAGGTCCTGTCTGGGCAGAAACTGCCTTGTGAACAAGGACGCCGGATGAAGCGAATCCATGCTGTGGCTAACATTGGCACGGCACTCAAGTTCCTCG AAGGAAGAAAGATTAAATTAGTCAACATTAACTCCACCGATATAGCTGATGGCCGACCCTCAATAGTTCTTGGATTGATGTGGACCATTATTCTATATTT CCAGATTGAAGAGTTGACCAGCAACCTGCCCCAGCTCCAGTCTTTGTCCAGCAGCGCATCCTCCGTGGACAGCATAGTTAGCTCTGAGACTCCCAGCCCA CCAAGTAAACGGAAGGTGACCACCAAGATCCAAGGAAATGCTAAGAAGGCTTTATTAAAGTGGGTTCAGTACACAGCTGGCAAGCAGACTGGAATAGAAG TAAAAGATTTTGGGAAGAGTTGGAGAAGCGGGGTTGCCTTTCATTCAGTTATTCATGCCATTCGACCGGAATTGGTGGACTTGGAGACAGTGAAAGGCAG ATCCAACCGAGAAAATTTGGAGGATGCTTTCACTATCGCCGAAACAGAACTGGGGATCCCAAGACTGCTAGATCCTGAAGACGTTGATGTGGATAAACCA GATGAGAAATCTATTATGACCTATGTAGCCCAGTTTCTGAAACATTATCCTGACATCCACAATGCAAGCACTGATGGGCAAGAGGATGATGAAATACTTC CAGGTTTCCCATCTTTTGCAAATTCTGTACAAAATTTTAAGAGAGAAGACAGAGTAATTTTTAAGGAAATGAAAGTTTGGATAGAACAATTTGAGAGAGA TTTGACAAGAGCACAGATGGTGGAATCAAATTTACAGGATAAATATCAGTCATTTAAGCACTTCAGAGTTCAATATGAAATGAAGAGGAAACAGATTGAA CATTTAATACAACCATTACACAGAGACGGTAAATTGTCACTTGACCAAGCATTGGTAAAACAATCTTGGGATAGAGTGACCTCCAGGCTCTTTGACTGGC ATATACAGCTTGATAAATCTCTTCCTGCACCTCTGGGCACCATAGGTGCCTGGCTGTACAGAGCGGAGGTGGCCCTGAGAGAGGAAATAACCGTTCAACA GGTCCACGAGGAAACAGCAAACACGATACAACGGAAACTTGAGCAACATAAGGATCTGCTTCAAAACACGGATGCCCACAAAAGAGCATTCCATGAAATC TACCGGACCAGGTCTGTTAACGGGATTCCAGTGCCACCTGATCAATTAGAGGACATGGCCGAGAGGTTTCATTTTGTTTCCTCCACATCAGAGCTACACC TAATGAAAATGGAATTTTTAGAATTAAAGTACCGTCTGCTCTCACTGCTGGTTCTTGCAGAGTCAAAGCTGAAGTCTTGGATCATTAAGTACGGGAGGAG AGAGTCAGTGGAGCAGCTTCTACAAAACTACGTGTCTTTTATAGAAAATAGCAAGTTCTTTGAACAATATGAGGTGACATACCAGATCTTGAAACAGACA GCTGAGATGTATGTCAAAGCAGATGGTTCAGTGGAAGAAGCTGAGAATGTGATGAAATTCATGAATGAAACCACCGCTCAGTGGAGGAATCTCTCAGTAG AAGTGAGGAGTGTGAGGAGCATGCTGGAAGAAGTGATCTCTAACTGGGATCGCTATGGCAATACAGTGGCTAGTCTGCAAGCCTGGCTAGAGGATGCTGA AAAAATGCTCAATCAATCAGAAAATGCCAAAAAGGATTTTTTTCGAAATTTACCTCATTGGATTCAGCAGCATACTGCCATGAACGATGCTGGCAATTTT CTAATTGAAACCTGTGATGAGATGGTTTCCCGTGACCTGAAGCAGCAATTACTGTTGCTAAATGGGCGGTGGAGGGAGTTGTTTATGGAAGTCAAGCAAT ATGCTCAAGCTGATGAGATGGACAGAATGAAGAAGGAATACACAGACTGTGTTGTTACCCTGTCTGCTTTTGCAACGGAAGCCCATAAGAAACTTTCTGA ACCCTTAGAAGTCTCTTTTATGAATGTCAAGCTATTAATTCAAGACTTGGAGGATATTGAGCAGAGGGTGCCTGTGATGGATGCCCAATACAAGATAATT ACAAAGACAGCACACCTCATTACCAAAGAAAGCCCCCAAGAAGAAGGAAAAGAAATGTTTGCGACCATGTCAAAGCTCAAAGAGCAGCTAACCAAGGTCA AAGAATGTTACTCCCCACTCCTTTATGAGTCTCAGCAGCTGTTGATTCCGTTGGAGGAATTAGAAAAGCAGATGACGTCCTTTTATGACTCACTTGGGAA AATCAATGAAATTATCACAGTTCTTGAGCGTGAGGCACAATCGAGTGCCCTTTTTAAACAAAAACATCAGGAACTGTTAGCTTGTCAAGAAAACTGTAAG AAAACCTTGACACTTATTGAGAAAGGCAGTCAAAGTGTTCAAAAGTTTGTGACCTTGAGCAACGTGTTAAAGCATTTTGATCAGACGAGGCTACAAAGAC AGATTGCAGATATTCATGTTGCTTTTCAGAGTATGGTAAAGAAAACTGGAGATTGGAAGAAGCATGTGGAAACCAACAGTCGCTTGATGAAGAAGTTTGA GGAGTCTCGAGCAGAGTTGGAGAAGGTACTGCGGATTGCTCAGGAGGGCCTGGAGGAAAAGGGGGATCCAGAGGAGCTCCTGCGGAGACACACTGAGTTT TTCAGTCAGCTGGATCAGAGGGTGCTCAATGCTTTCCTGAAAGCTTGTGATGAACTCACCGACATCCTTCCAGAGCAGGAGCAGCAGGGGCTGCAGGAAG CTGTTCGAAAGCTCCACAAACAATGGAAGGATCTTCAAGGAGAAGCCCCTTATCATTTGCTTCATCTGAAGATTGATGTGGAGAAGAATAGGTTCTTAGC CTCTGTAGAAGAATGCAGAACTGAGCTGGATCGAGAGACCAAGCTGATGCCCCAGGAAGGCAGTGAAAAGATAATTAAAGAGCACAGGGTTTTCTTCAGT GACAAAGGTCCTCATCATCTCTGTGAGAAAAGGTTACAGCTCATCGAGGAACTCTGTGTGAAACTCCCAGTGCGGGACCCAGTAAGGGACACACCTGGAA CCTGTCACGTGACTCTCAAAGAGCTCAGAGCTGCCATTGACAGCACCTACAGGAAGCTCATGGAAGACCCAGACAAGTGGAAGGACTACACTAGCAGATT CTCTGAGTTCTCATCTTGGATATCTACAAATGAGACACAATTAAAGGGGATCAAGGGTGAGGCCATCGATACTGCCAACCACGGAGAGGTTAAACGTGCC GTTGAAGAGATCAGAAATGGTGTTACCAAAAGGGGTGAGACCCTCAGCTGGCTGAAATCCAGGCTGAAAGTTTTGACAGAAGTTTCTTCTGAGAATGAAG CCCAAAAGCAGGGAGATGAGCTGGCAAAATTATCCAGCTCTTTCAAGGCTCTTGTGACGCTGCTGTCAGAGGTTGAAAAGATGCTAAGCAATTTTGGGGA CTGTGTCCAGTACAAAGAAATAGTCAAAAATTCTCTCGAAGAATTAATTTCTGGCTCTAAAGAAGTCCAGGAACAAGCTGAGAAGATCTTGGATACTGAA AATCTGTTTGAAGCACAGCAGTTACTTCTTCATCACCAGCAAAAGACAAAGCGGATCTCAGCAAAGAAGAGAGATGTGCAGCAGCAGATCGCGCAGGCGC AGCAGGGAGAAGGGGGGCTGCCTGACCGAGGCCACGAGGAGCTGCGGAAGCTGGAGAGCACACTGGATGGCCTGGAGCGCAGCCGGGAGAGGCAGGAACG CCGCATCCAGGTCACATTAAGAAAATGGGAGCGATTTGAAACAAACAAAGAAACAGTAGTAAGATACCTTTTTCAAACAGGTTCCAGTCATGAACGCTTC TTGAGTTTTAGCAGTTTGGAAAGTTTATCTTCAGAACTGGAACAAACAAAGGAGTTTTCTAAACGGACAGAAAGTATTGCAGTCCAGGCTGAGAACCTTG TAAAGGAAGCTTCAGAGATACCGCTTGGGCCCCAAAATAAGCAGCTGCTTCAACAGCAGGCCAAGTCAATCAAAGAACAAGTCAAAAAATTAGAAGACAC GCTTGAAGAAGATATTAAAACCATGGAAATGGTGAAAACCAAGTGGGATCATTTTGGCAGTAATTTTGAGACTCTGTCCGTCTGGATAACTGAGAAAGAA AAAGAACTCAATGCCTTGGAAACTTCGTCATCTGCCATGGACATGCAAATCAGCCAAATTAAGGTCACAATTCAGGAAATAGAAAGTAAGCTCAGCAGCA TTGTAGGATTAGAAGAAGAAGCCCAGTCTTTTGCTCAGTTTGTTACCACTGGAGAATCTGCTCGAATTAAAGCCAAGTTGACACAAATAAGAAGATACGG GGAAGAGCTTCGAGAGCATGCACAGTGTCTGGAAGGAACAATCCTGGGACATTTATCTCAGCAGCAAAAGTTTGAAGAGAACCTTAGAAAGATCCAGCAA TCTGTGTCTGAATTTGAAGATAAACTTGCTGTTCCAATTAAAATATGTTCTTCAGCTACAGAAACATACAAAGTTCTTCAAGAACATATGGATCTCTGCC AGGCCCTGGAGTCACTGAGCAGCGCGATCACTGCCTTCTCAGCCAGTGCCAGGAAGGTTGTGAACAGAGATTCCTGTGTTCAGGAGGCTGCGGCTCTACA GCAGCAATACGAGGACATCCTAAGGAGGGCGAAGGAGAGACAGACGGCGCTGGAGAATCTGCTGGCCCACTGGCAGAGGCTAGAGAAAGAACTATCATCC TTTTTGACCTGGTTAGAGCGGGGTGAAGCTAAAGCCAGTTCCCCAGAAATGGACATTTCTGCAGACAGAGTCAAAGTGGAAGGTGAACTTCAGTTAATAC AGGCACTGCAAAATGAAGTTGTATCCCAGGCCTCATTCTATAGCAAACTTTTGCAATTGAAGGAATCATTGTTCTCAGTAGCCTCCAAAGATGATGTGAA AATGATGAAACTACATTTGGAGCAGTTGGATGAGAGATGGAGAGATTTACCACAGATCATTAACAAAAGGATTAATTTTCTTCAGTCTGTGGTTGCTGAA CACCAGCAATTTGATGAGCTGCTGCTTTCCTTTTCTGTCTGGATTAAACTGTTTCTCAGTGAATTACAAACTACCTCTGAGATTAGCATAATGGACCATC AAGTAGCCCTTACTCGGCATAAGGACCACGCAGCAGAAGTAGAGAGCAAAAAGGGCGAATTGCAGAGTCTGCAGGGTCACTTAGCAAAGTTGGGTTCTCT GGGCCGTGCTGAGGACCTCCACCTCCTGCAGGGAAAGGCTGAGGACTGCTTCCAGCTGTTTGAGGAGGCCAGCCAGGTTGTGGAGAGGCGGCAGCTTGCC CTGTCCCATTTGGCAGAATTCCTCCAGAGCCATGCCTCTCTGTCCGGCATTCTCCGCCAGCTGAGGCAAACAGTGGAAGCAACCAACAGTATGAATAAGA ACGAGTCTGATTTGATAGAAAAGGACCTCAATGATGCTCTTCAAAATGCTAAAGCATTAGAATCTGCTGCCGTCAGTCTGGATGGCATTCTTTCCAAAGC CCAATACCATCTGAAAATCGGGAGCTCTGAGCAAAGGACTTCCTGCAGAGCCACGGCTGATCAGCTCTGTGGAGAGGTAGAGAGGATCCAGAACCTTCTG GGAACCAAGCAGAGTGAGGCAGATGCTCTGGCAGTGTTGAAAAAAGCATTCCAAGACCAGAAAGAGGAGCTTCTGAAAAGCATTGAGGACATTGAAGAAA GGACTGACAAAGAGCGATTGAAAGAACCTACCCGCCAAGCTCTTCAGCAGAGGTTAAGAGTGTTTAATCAGCTAGAAGATGAATTGAATTCTCACGAGCA TGAACTATGTTGGTTGAAAGACAAAGCCAAGCAAATTGCCCAGAAAGATGTAGCTTTTGCACCTGAAGTTGACAGGGAGATAAACCGCTTAGAGGTCACC TGGGATGATACCAAAAGACTAATTCATGAAAATCAGGGTCAGTGCTGTGGACTTATTGACTTAATGAGAGAATATCAGAACCTGAAATCAGCTGTATCTA AAGTCTTAGAAAATGCCAGCAGTGTGATTGTAACCAGAACTACCATAAAAGATCAGGAGGATCTTAAATGGGCTTTTTCCAAGCATGAAACTGCCAAGAA CAAAATGAATTACAAACAGAAAGACTTGGATAACTTTACCAGCAAAGGAAAACACTTGTTATCTGAGCTGAAGAAAATTCACAGTAGTGATTTCAGCTTG GTGAAAACAGACATGGAGAGCACCGTGGACAAATGGCTGGATGTATCAGAGAAACTTGAAGAAAACATGGATAGGCTGAGAGTAAGCCTGTCCATTTGGG ATGATGTACTGTCAACTAGAGATGAGATTGAGGGATGGTCAAACAACTGCGTTCCACAGATGGCAGAAAACATCAGCAACCTGGATAACCACCTCAGAGC TGAAGAACTGCTTAAAGAATTTGAGTCTGAAGTTAAAAACAAAGCATTGAGATTGGAAGAACTGCATTCCAAAGTTAATGATCTGAAAGAATTAACTAAA AATCTAGAAACACCGCCAGACCTTCAGTTTATAGAAGCAGACTTAATGCAGAAACTGGAGCATGCCAAAGAAATAACTGAAGTAGCAAAAGGAACCCTGA AGGATTTCACGGCTCAAAGTACACAAGTGGAGAAGTTTATTAATGACATAACAACATGGTTCACAAAAGTGGAAGAATCGTTGATGAACTGTGCCCAAAA TGAGACTTGTGAAGCATTGAAAAAAGTCAAGGATATACAAAAAGAACTTCAAAGTCAACAAAGCAACATCAGCTCTACCCAAGAAAATCTCAATAGCTTG TGCCGCAAGTACCACTCAGCTGAGTTGGAGAGCCTGGGCCGTGCAATGACTGGTCTGATAAAGAAACATGAAGCCGTGAGCCAGTTGTGCTCCAAAACCC AGGCCAGCCTGCAGGAATCTCTGGAAAAACACTTCAGTGAGTCTATGCAGGAATTCCAAGAATGGTTTTTGGGAGCAAAGGCAGCAGCAAAAGAATCATC AGATCGCACCGGTGACAGCAAAGTTCTAGAAGCAAAGCTCCATGATCTTCAGAACATTTTGGACTCAGTCAGTGATGGGCAGAGCAAACTTGATGCAGTG ACTCAAGAAGGACAAACTTTGTATGCACATTTGTCTAAACAAATTGTCAGTAGCATTCAAGAACAAATCACAAAGGCCAATGAAGAGTTTCAAGCATTTC TGAAACAATGCCTTAAAGATAAGCAGGCTCTTCAAGACTGTGCTTCAGAACTTGGAAGCTTTGAAGATCAGCACAGAAAACTGAACTTATGGATCCATGA AATGGAAGAAAGGTTCAATACGGAAAACTTGGGAGAGAGTAAACAGCACATTCCTGAGAAGAAAAATGAAGTTCATAAAGTTGAAATGTTTTTGGGAGAA CTGCTGGCTGCAAGAGAGTCTCTTGATAAGCTTTCCCAGAGAGGGCAGCTTCTGAGTGAAGAAGGCCACGGTGCTGGGCAGGAGGGCCGCCTGTGTTCCC AGCTCCTCACAAGCCACCAGAACCTACTTAGAATGACCAAAGAGAAACTCCGGAGCTGCCAGGTGGCCCTTCAGGAGCACGAAGCCCTGGAGGAAGCACT GCAAAGCATGTGGTTCTGGGTGAAGGCCATTCAGGACAGACTGGCCTGTGCAGAGAGCACTCTTGGGAGCAAAGACACCCTGGAGAAACGGCTGTCACAA ATACAGGATATTCTCCTGATGAAAGGTGAAGGGGAAGTTAAGTTGAATATGGCCATTGGCAAGGGGGAACAGGCCTTGAGAAGTAGCAACAAAGAAGGTC AGAGGGTGATTCAGACTCAGTTAGAGACCCTTAAAGAAGTGTGGGCTGACATCATGAGCTCCTCCGTCCACGCTCAAAGCACTTTAGAGTCTGTGATTAG CCAATGGAATGACTATGTAGAGAGGAAAAACCAGTTGGAGCAGTGGATGGAATCAGTGGATCAAAAAATAGAACATCCCTTACAACCACAGCCAGGTCTG AAAGAGAAGTTCGTCCTGCTTGACCACCTCCAGTCCATCCTGTCTGAGGCAGAAGATCACACGAGAGCCCTTCACCGTCTAATTGCGAAGTCCAGGGAGC TCTACGAAAAGACAGAGGATGAGTCTTTCAAGGACACAGCTCAAGAGGAGCTGAAAACACAGTTTAATGATATAATGACTGTTGCCAAGGAAAAAATGAG GAAAGTGGAAGAGATTGTGAAAGATCATCTAATGTATTTAGATGCGGTCCACGAGTTCACAGATTGGCTCCATTCAGCAAAGGAAGAACTTCACCGGTGG TCAGATATGTCTGGAGATTCATCAGCCACCCAGAAAAAGTTATCAAAAATTAAGGAGCTGATAGATTCCAGAGAGATTGGTGCAAGCCGTCTCAGCAGAG TGGAGTCGCTGGCTCCCGAAGTGAAACAGAACACAACTGCCAGTGGGTGTGAGCTCATGCACACGGAGATGCAGGCCCTGCGTGCCGACTGGAAGCAGTG GGAAGACAGTGTATTCCAAACGCAGAGCTGTTTGGAGAACCTGGTCAGCCAGATGGCCCTTTCGGAGCAGGAATTCTCAGGCCAAGTGGCTCAACTGGAG CAGGCCCTGGAACAGTTCAGTGCCCTTCTGAAAACCTGGGCTCAGCAGTTAACCCTCCTGGAAGGCAAGAACACGGATGAGGAGATAGTGGAATGCTGGC ACAAAGGACAAGAGATACTGGATGCTTTGCAAAAAGCAGAGCCTAGAACAGAGGATCTCAAGTCTCAGCTGAATGAACTTTGTCGATTTTCCAGAGACCT GAGTACCTACAGTGGAAAAGTTTCTGGCTTGATTAAAGAGTATAATTGTCTTTGTTTGCAAGCATCCAAGGGCTGCCAGAATAAAGAACAGATTTTACAG CAAAGATTTCGAAAGGCCTTCAGGGATTTCCAGCAGTGGTTGGTTAATGCAAAAATCACTACCGCCAAGTGTTTTGATATACCTCAAAATATAAGTGAAG TTTCAACTAGTCTTCAGAAAATACAGGAGTTTTTGTCAGAAAGTGAAAATGGACAGCACAAGCTAAACATGATGCTGTCTAAAGGGGAACTTCTGAGTAC CCTGCTGACCAAAGAGAAAGCGAAAGGGATCCAGGCCAAAGTTACAGCTGCAAAAGAAGATTGGAAAAATTTTCATTCAAATCTCCACCAAAAAGAATCT GCTCTAGAGAATCTAAAGATCCAAATGAAGGACTTTGAAGTAAGTGCTGAGCCTATCCAGGACTGGCTGAGTAAAACTGAGAAGATGGTCCATGAAAGCA GCAATCGCCTCTATGATCTGCCAGCAAAGAGGAGGGAGCAGCAGAAGCTCCAGTCTGTCCTTGAGGAAATACACTGCTACGAGCCTCAGCTCAACAGGCT GAAAGAGAAAGCTCAGCAGCTGTGGGAAGGACAAGCTGCCAGCAAGAGCTTTAGGCACAGAGTGTCGCAGCTGTCTTCTCAGTATCTAGCGCTAAGCAAT TTAACAAAGGAGAAAGTGTCAAGACTGGATAGAATCGTTGCAGAACACAATCAGTTCTCTCTTGGGATTAAAGAATTACAAGACTGGATGACGGATGCGA TTCACATGCTGGATTCATACTGCCACCCGACATCCGACAAAAGTGTGCTGGACAGCAGGACGCTCAAGCTCGAGGCTCTATTATCAGTCAAACAGGAAAA AGAGATTCAGATGAAAATGATAGTGACCAGGGGAGAATCTGTCCTTCAGAATACTTCTCCAGAAGGCATTCCCACTATTCAGCAGCAGCTGCAGAGTGTG AAGGATATGTGGGCATCCCTTTTGTCTGCAGGGATTCGTTGTAAAAGCCAACTCGAAGGAGCTCTCTCCAAGTGGACAAGTTATCAGGATGGCGTTCGAC AGTTCTCCGGTTGGATGGATAGTATGGAAGCCAACCTGAATGAATCAGAAAGGCAGCATGCGGAGCTGCGGGATAAAACAACGATGCTCGGAAAAGCCAA GTTATTAAATGAAGAAGTGCTGAGTTACAGCAGCTTGCTGGAGACCATCGAAGTCAAAGGGGCTGGCATGACAGAACACTATGTCACCCAGCTAGAACTC CAGGATCTACAGGAACGATACAGAGCCATCCAAGAGAGGGCCAAGGAAGCCGTAACCAAGTCTGAAAAACTTGTCCGCCTGCACCAAGAGTATCAGAGAG ACCTAAAGGCATTTGAAGTTTGGTTGGGGCAAGAACAAGAAAAGCTCGACCAGTATTCAGTTCTTGAAGGTGATGCCCACACTCATGAGACAACATTGCG TGATCTTCAGGAGCTACAGGTACACTGTGCAGAGGGGCAGGCCCTGTTGAACTCAGTGCTGCACACCAGAGAGGATGTGATCCCATCAGGTATCCCACAG GCAGAGGACCGGGCTTTAGAGTCTCTCCGGCAAGACTGGCAGGCTTACCAGCACAGGCTGTCCGAGACTCGAACTCAGTTCAATAACGTGGTGAACAAAT TGAGGCTAATGGAGCAAAAGTTTCAGCAAGTAGATGAATGGCTCAAAACAGCAGAGGAGAAAGTTAGTCCCAGGACCAGACGTCAGTCTAACAGGGCAAC CAAGGAGATACAATTACATCAGATGAAGAAGTGGCACGAAGAAGTGACTGCATACAGAGATGAAGTTGAGGAAGTGGGAGCTAGAGCTCAGGAGATACTG GACGAGAGCCACGTGAACAGCAGAATGGGTTGCCAGGCCACCCAGCTGACTTCCAGATACCAGGCCCTGCTTCTCCAAGTGCTGGAACAAATAAAATTCC TGGAGGAGGAGATTCAGAGTTTGGAGGAATCAGAATCATCCCTCAGTTCCTATTCTGATTGGTATGGCTCTACTCATAAAAACTTCAAGAATGTGGCTAC CAAGATTGACAAAGTAGATACAGTAATGATGGGGAAGAAATTGAAGACGTTGGAGGTTTTGCTCAAAGACATGGAGAAAGGTCACAGTTTGCTGAAATCA GCCCGGGAGAAAGGAGAGAGGGCTGTTAAATACTTGGAGGAAGGCGAGGCAGAGAGGTTAAGAAAGGAGATTCATGATCACATGGAGCAGTTGAAGGAAC TGACCAGCACTGTCCGGAAAGAACACATGACGCTGGAAAAAGGTCTTCATTTAGCAAAGGAATTCTCAGATAAATGCAAAGCACTGACACAGTGGATAGC AGAATACCAGGAAATTCTACATGTTCCTGAAGAACCCAAAATGGAATTATATGAGAAAAAAGCTCAGTTATCTAAATACAAGTCACTTCAACAAACGGTG CTGTCCCATGAACCATCAGTAAAGTCAGTGAGAGAGAAGGGTGAAGCTCTTTTGGAACTGGTGCAGGACGTCACTTTAAAGGACAAAATAGATCAACTTC AAAGTGATTACCAGGACCTGTGCAGCATAGGAAAGGAGCATGTCTTCAGTCTGGAGGCGAAAGTCAAAGACCATGAAGACTACAACAGTGAGCTCCAAGA GGTCGAAAAGTGGCTGCTGCAGATGTCTGGCAGACTGGTGGCACCTGACCTCCTGGAGACAAGCAGCCTGGAGACAATCACCCAGCAATTGGCCCACCAC AAGGCAATGATGGAAGAAATTGCTGGTTTTGAAGACCGTTTGAACAATCTTCAAATGAAAGGTGATACTTTGATTGGCCAATGTGCAGACCACCTGCAAG CGAAACTTAAACAAAACGTGCATGCTCATCTGCAGGGCACAAAGGACAGCTACTCAGCGATCTGCAGCACAGCTCAGAGGATGTACCAGAGTTTGGAACA CGAACTTCAGAAGCACGTCAGCCGACAAGACACCCTGCAGCAGTGCCAGGCCTGGCTTTCTGCAGTCCAGCCGGATTTAGAGCCAAGTCCTCAACCACCT CTTAGTAGGGCAGAAGCCATTAAGCAGGTCAAACACTTCAGAGCTTTGCAAGAGCAGGCAAGGACCTACCTAGATCTCCTTTGCTCCATGTGTGACCTGT CAAATGCTTCGGTGAAAACCACAGCAAAAGACATTCAACAAACAGAGCAAACGATTGAACAAAAGCTTGTCCAGGCCCAGAACTTAACTCAGGGCTGGGA AGAGATCAAGCACCTGAAGTCTGAGCTCTGGATTTACCTGCAAGATGCTGATCAGCAACTGCAGAACATGAAGAGGAGGCACTCTGAGCTGGAGCTGAAC ATTGCACAGAACATGGTTTCACAAGTTAAGGATTTTGTTAAGAAACTACAGAGCAAACAGGCATCCGTGAACACCATAATAGAAAAGGTGAATAAGTTAA CAAAGAAGGAGGAATCGCCTGAACACAAGGAAATAAATCATTTAAATGATCAGTGGCTCGATTTGTGCCGTCAGTCTAACAACCTGTGCTTGCAAAGGGA AGAGGATCTTCAGAGAACAAGAGATTACCATGACTGTATGAATGTTGTTGAAGTGTTCCTAGAAAAATTTACTACAGAATGGGATAACTTGGCCAGATCT GATGCAGAGAGTACAGCTGTCCACCTGGAAGCTTTGAAAAAGTTAGCATTGGCATTGCAGGAGAGAAAGTATGCTATTGAAGATCTGAAAGATCAAAAGC AGAAAATGATAGAGCATCTGAATTTAGATGACAAGGAGTTAGTCAAAGAACAGACGAGTCATTTAGAGCAACGTTGGTTTCAGCTTGAGGACCTCATTAA AAGGAAAATCCAAGTGTCAGTCACCAACTTGGAGGAGTTAAATGTGGTGCAGTCCAGATTTCAGGAGCTAATGGAGTGGGCAGAAGAGCAACAACCCAAC ATCGCCGAGGCCCTTAAGCAGAGCCCTCCTCCAGATATGGCTCAGAACCTTCTCATGGATCACCTGGCCATCTGCAGTGAACTGGAGGCCAAGCAGATGC TCCTGAAATCGCTTATAAAGGACGCAGACAGGGTCATGGCAGATCTTGGTCTCAATGAGCGACAGGTCATCCAGAAGGCTCTCTCTGATGCACAAAGCCA CGTGAATTGTCTCAGTGACTTAGTGGGCCAGCGAAGAAAGTACTTAAACAAAGCCTTGTCCGAGAAAACCCAGTTTCTCATGGCAGTGTTCCAGGCCACC AGCCAAATTCAGCAACATGAGCGAAAGATAATGTTCCGTGAACACATCTGTCTGTTACCAGATGATGTGAGCAAACAAGTCAAAACATGTAAGAGTGCAC AAGCCAGCCTCAAGACTTACCAAAATGAAGTCACTGGACTTTGGGCCCAGGGTCGCGAACTAATGAAGGAAGTCACAGAGCAGGAAAAGAGTGAAGTGCT GGGGAAGCTTCAGGAATTGCAGAGTGTCTATGACAGTGTTTTACAAAAGTGCAGTCACCGGTTACAAGAACTAGAGAAGAATTTGGTTTCTAGGAAGCAT TTTAAGGAAGATTTTGATAAAGCTTGCCACTGGCTAAAACAAGCAGATATTGTTACATTTCCTGAAATCAACCTAATGAATGAGAGTTCTGAGCTTCATA CACAACTGGCTAAATACCAAAACATTCTTGAACAATCTCCAGAATATGAAAATCTTCTACTTACGCTGCAGAGAACTGGGCAGACCATATTACCATCGCT GAATGAAGTCGATCATTCCTACCTCAGTGAAAAGCTAAATGCTTTGCCTCGACAATTTAATGTAATTGTTGCCTTGGCTAAAGACAAGTTCTATAAAGTC CAGGAAGCAATTCTTGCTCGGAAGGAATATGCTTCCTTGATTGAGTTGACAACCCAGTCTCTGAGTGAACTTGAAGCCCAATTCTTGAGGATGAGCAAAG TTCCCACCGACCTGGCCGTTGAGGAGGCTCTTTCTCTGCAAGATGGTTGCAGAGCCATTCTGGACGAGGTGGCGGGCCTTGGGGAGGCGGTGGATGAACT GAACCAGAAAAAAGAAGGTTTTCGCAGCACAGGTCAGCCTTGGCAGCCAGACAAGATGCTGCACCTTGTCACCTTATATCACAGGCTGAAGCGACAAACA GAACAGAGGGTTAGCTTATTAGAAGACACCACCAGTGCTTACCAAGAACACGAGAAGATGTGCCAACAGCTGGAGAGACAACTGAAGTCTGTAAAAGAGG AGCAGTCCAAAGTGAATGAGGAAACGCTGCCTGCAGAGGAGAAGCTCAAAATGTATCACTCCCTGGCAGGAAGTCTCCAGGACTCAGGGATTGTACTGAA ACGAGTAACCATACATCTTGAAGATCTTGCCCCACACCTTGACCCCTTGGCTTATGAGAAAGCCAGGCATCAGATCCAGTCCTGGCAAGGGGAGTTAAAA CTGTTGACTTCTGCCATTGGTGAGACGGTGACAGAATGTGAGAGCCGAATGGTGCAGAGTATAGACTTCCAGACTGAGATGAGTCGCTCCCTGGACTGGC TGAGGAGAGTGAAGGCAGAGCTCAGTGGGCCGGTGTACCTAGACCTCAACCTGCAGGACATCCAAGAGGAAATCAGAAAAATCCAAATTCATCAGGAAGA GGTCCAGTCCAGCTTGAGAATCATGAATGCGCTGAGTCACAAGGAAAAGGAGAAGTTCACAAAGGCCAAGGAGCTGATTTCTGCGGATTTAGAACACAGC CTCGCTGAGCTCTCAGAGCTGGATGGAGACATCCAGGAAGCCTTACGCACCAGACAGGCTACCTTGACTGAAATATATAGCCAGTGTCAAAGGTATTATC AGGTATTTCAAGCAGCCAATGACTGGCTTGAGGATGCCCAAGAATTGTTACAGCTGGCAGGCAATGGCCTAGACGTGGAGAGCGCAGAGGAAAATCTCAA AAGCCACATGGAATTTTTCAGTACAGAGGATCAGTTCCATAGTAACCTGGAGGAGCTCCACAGCCTGGTAGCCACCCTGGACCCACTCATCAAGCCAACC GGCAAAGAAGACCTAGAACAGAAAGTGGCTTCTCTGGAACTCAGGAGCCAGAGGATGAGCCGGGACTCTGGTGCCCAAGTGGATCTCTTGCAGAGATGCA CAGCTCAATGGCACGATTACCAGAAAGCAAGGGAAGAGGTTATTGAATTGATGAATGATACAGAAAAGAAATTGTCTGAGTTTTCTTTGTTGAAGACTTC GTCTAGTCATGAAGCGGAAGAAAAATTGTCAGAACACAAGGCTTTAGTGTCAGTGGTTAACTCTTTCCATGAGAAAATTGTGGCCCTTGAGGAAAAAGCT TCACAACTGGAGAAAACCGGAAATGATGCCAGCAAAGCCACCCTGAGCAGGTCAATGACCACCGTCTGGCAGCGCTGGACACGCCTTCGAGCTGTGGCCC AGGACCAGGAGAAGATCCTGGAAGATGCAGTGGATGAGTGGACGGGCTTTAACAACAAGGTTAAAAAGGCCACTGAAATGATTGATCAGCTGCAAGATAA GTTACCTGGAAGTTCAGCAGAGAAAGCATCGAAAGCAGAGCTCTTAACTCTTCTTGAATACCACGACACGTTCGTTCTGGAGCTGGAGCAGCAGCAGTCG GCCTTGGGCATGCTGCGGCAGCAAACCCTGAGCATGCTCCAGGATGGAGCCGCCCCAACCCCTGGGGAAGAGCCTCCGCTCATGCAGGAAATCACCGCCA TGCAAGATCGGTGCCTGAACATGCAGGAGAAAGTGAAGACTAATGGAAAGTTGGTGAAGCAAGAGCTGAAGGACCGAGAAATGGTGGAGACTCAGATCAA TTCTGTGAAATGTTGGGTTCAGGAAACGAAAGAATATTTAGGGAATCCAACAATAGAAATAGATGCTCAACTTGAAGAACTTCAGATTCTCCTAACAGAA GCCACAAATCACCGACAGAACATTGAAAAAATGGCAGAAGAACAGAAGGAGAAGTACTTAGGTCTTTATACCATATTACCTTCTGAACTCTCCCTTCAGT TGGCTGAAGTGGCGTTAGATCTAAAGATCCGAGATCAGATCCAAGACAAAATAAAAGAAGTTGAGCAGAGCAAGGCCACGAGCCAGGAACTCAGCCGGCA AATTCAGAAGTTAGCTAAAGACCTCACAACTATTCTAACTAAGCTGAAAGCGAAGACAGATAATGTAGTTCAAGCTAAAACTGACCAAAAGGTGCTGGGA GAGGAATTAGATGGCTGTAATTCAAAGTTAATGGAATTAGATGCAGCAGTACAGAAATTCTTGGAACAGAATGGCCAACTGGGTAAGCCACTGGCCAAGA AGATAGGAAAACTGACTGAACTTCACCAGCAGACCATTAGACAAGCTGAGAATCGGCTCTCCAAGCTCAATCAGGCAGCATCACATTTAGAAGAATACAA TGAAATGCTTGAATTAATTTTGAAGTGGATTGAAAAAGCTAAAGTCTTGGCTCATGGAACTATTGCATGGAATTCTGCAAGCCAGCTTCGGGAACAATAT ATTTTGCATCAGACCCTGCTAGAAGAATCCAAAGAAATTGACAGTGAGCTGGAAGCAATGACTGAGAAATTACAGTACCTCACTAGCGTGTACTGTACAG AAAAAATGTCTCAGCAAGTGGCAGAACTGGGACGGGAGACTGAGGAGTTGCGACAGATGATCAAAATTCGTTTGCAGAACCTCCAAGATGCAGCTAAGGA TATGAAAAAATTTGAAGCAGAGTTGAAAAAGTTACAAGCTGCCTTGGAGCAAGCCCAGGCAACACTGACTTCTCCAGAAGTTGGACGTCTCAGTCTCAAG GAGCAGCTCTCTCATCGGCAGCATTTGTTGTCTGAGATGGAGTCACTGAAGCCGAAGGTGCAAGCAGTGCAGCTCTGCCAGAGTGCCCTCCGGATCCCCG AGGATGTGGTTGCCAGCTTACCTCTCTGTCATGCTGCTCTGCGGCTGCAGGAAGAGGCCAGCCGGCTGCAGCACACCGCCATCCAGCAGTGTAACATCAT GCAGGCAGCTGTGGTACAATATGAACAATATGAGCAAGAAATGAAACATCTCCAGCAACTGATAGAAGGAGCTCACAGAGAGATTGAGGATAAACCTGTT GCCACCAGTAACATACAGGAGCTGCAGGCTCAGATTTCTCGGCATGAGGAGCTGGCGCAGAAAATTAAGGGCTACCAGGAGCAGATCGCTTCTTTGAATT CCAAGTGCAAGATGCTGACGATGAAAGCCAAGCACGCCACCATGCTGCTGACGGTGACCGAGGTCGAGGGGCTGGCGGAAGGGACAGAGGACCTGGATGG GGAGCTCCTCCCCACGCCTTCGGCCCACCCCTCTGTGGTCATGATGACTGCAGGTCGCTGTCACACTTTGCTGTCACCGGTCACTGAGGAGTCTGGGGAG GAGGGAACCAACAGTGAGATTTCCTCTCCACCTGCCTGTCGCTCCCCTTCACCTGTGGCTAATACAGATGCTTCTGTTAACCAGGACATTGCATATTACC AAGCCTTGTCTGCTGAGAGGTTGCAGACAGATGCTGCAAAAATTCACCCCAGCACATCCGCATCCCAGGAGTTCTATGAACCGGGATTGGAGCCATCCGC TACTGCCAAACTGGGTGATTTGCAGCGTTCTTGGGAAACCTTAAAGAATGTGATCAGTGAGAAGCAGCGCACACTCTATGAAGCTTTGGAACGCCAGCAG AAGTACCAGGACTCCCTCCAGTCCATCTCTACGAAGATGGAGGCCATTGAGCTGAAACTCAGTGAGAGCCCAGAGCCTGGCAGGAGTCCAGAAAGCCAGA TGGCTGAACATCAGGCATTGATGGATGAGATTCTCATGCTCCAGGATGAAATCAATGAGCTCCAGTCCTCTCTCGCAGAGGAGCTGGTATCCGAGTCTTG TGAGGCCGACCCTGCGGAGCAGCTGGCCTTGCAGTCCACGCTCACTGTCTTAGCCGAGCGAATGTCCACCATCAGGATGAAAGCCTCGGGGAAACGGCAG CTTTTGGAGGAGAAGTTGAATGATCAGCTGGAGGAACAAAGGCAGGAACAGGCCCTGCAGAGGTATCGCTGTGAAGCCGATGAGCTGGACAGCTGGCTCT TGAGTACCAAGGCCACTCTGGACACTGCGCTGAGTCCACCCAAGGAGCCCATGGACATGGAGGCCCAGCTTATGGACTGCCAGAATATGCTGGTGGAAAT AGAGCAGAAGGTGGTGGCTTTATCAGAACTGTCAGTCCACAATGAGAACCTGCTGCTGGAGGGCAAAGCTCACACCAAGGACGAGGCCGAGCAGCTGGCT GGAAAGCTGAGAAGGCTCAAGGGGAGCCTGCTGGAGCTGCAGAGAGCCCTGCATGATAAGCAGCTCAACATGCAGGGAACAGCACAGGAGAAGGAGGAGA GCGATGTTGACCTAACAGCCACGCAGAGCCCCGGCGTCCAGGAATGGCTGGCCCAAGCTCGCACCACATGGACCCAGCAGCGGCAGAGCAGTCTCCAGCA ACAAAAAGAGTTAGAACAGGAATTAGCCGAGCAGAAGAGTCTCCTTCGCTCAGTAGCCAGTCGTGGAGAGGAGATTCTAATTCAACATTCGGCGGCAGAG ACCTCTGGTGATGCTGGCGAAAAACCTGATGTGTTATCCCAGGAGTTGGGGATGGAAGGGGAGAAATCATCCGCTGAAGACCAGATGAGAATGAAATGGG AAAGCCTACATCAAGAATTTAGTACCAAGCAGAAACTACTACAGAATGTTCTGGAACAGGAACAAGAGCAAGTGCTTTATAGCAGGCCAAATCGACTCTT GTCTGGTGTGCCACTGTACAAAGGGGACGTGCCAACCCAAGATAAATCTGCAGTTACATCTTTGCTGGATGGACTGAACCAAGCCTTCGAGGAGGTTTCA TCCCAGAGTGGAGGGGCAAAGAGGCAGAGTATACACTTGGAGCAGAAGTTGTATGATGGAGTCTCAGCCACCTCTACTTGGTTGGATGACGTTGAAGAAC GTTTATTTGTTGCCACAGCACTTTTACCAGAAGAAACAGAGACTTGTCTCTTCAACCAAGAGATTCTTGCCAAAGACATTAAGGAAATGTCTGAAGAAAT GGATAAGAACAAAAACTTGTTTTCCCAAGCTTTTCCAGAGAATGGTGATAATCGAGATGTTATTGAAGATACTTTGGGTTGTCTTTTGGGCAGGTTATCC TTGCTAGACTCAGTAGTGAATCAACGATGTCATCAGATGAAAGAAAGACTTCAGCAAATACTAAATTTCCAGAATGATCTGAAAGTGCTGTTTACATCAC TGGCTGACAACAAATACATCATTCTGCAAAAACTGGCAAATGTGTTTGAACAGCCCGTAGCAGAACAAATAGAGGCAATACAACAGGCTGAAGATGGACT CAAAGAATTTGATGCAGGAATCATTGAATTAAAGAGGCGTGGTGACAAGCTACAGGTCGAGCAGCCGTCCATGCAAGAACTCTCCAAGCTCCAGGACATG TATGATGAGCTGATGATGATCATTGGCTCCCGGAGGAGTGGTCTGAATCAGAACCTTACACTCAAGAGTCAGTATGAGAGGGCCCTACAAGATCTGGCTG ACCTGCTAGAAACTGGTCAGGAGAAGATGGCAGGAGACCAGAAAATCATCGTGTCTTCCAAAGAGGAAATCCAGCAACTACTTGACAAACATAAGGAATA CTTTCAGGGCCTGGAATCTCATATGATCTTGACTGAAACACTCTTCAGAAAGATAATCAGCTTTGCAGTCCAAAAGGAAACCCAGTTCCATACAGAGCTG ATGGCTCAGGCTTCTGCTGTACTGAAACGGGCTCACAAGAGGGGTGTGGAGCTGGAGTACATTCTAGAGACGTGGTCCCATCTGGATGAGGACCAGCAGG AGCTCAGCAGACAGCTGGAGGTGGTGGAAAGCAGCATCCCAAGCGTGGGTCTGGTGGAGGAGAACGAGGACAGGCTTATTGACCGCATAACACTCTACCA GCATTTAAAATCTAGCCTTAATGAATACCAGCCCAAATTATATCAAGTATTAGATGATGGGAAACGACTTCTGATATCCATCAGCTGCTCAGATCTAGAA AGCCAACTAAATCAACTTGGAGAGTGCTGGCTAAGTAACACCAATAAAATGTCTAAGGAACTTCACAGACTGGAAACAATATTGAAACACTGGACCAGAT ATCAAAGTGAATCTGCAGATCTAATTCACTGGTTACAATCTGCAAAAGACCGGCTAGAATTTTGGACTCAGCAATCTGTGACAGTCCCACAAGAGCTGGA AATGGTCCGTGATCATCTAAATGCTTTCCTGGAGTTTTCTAAAGAAGTGGATGCCCAATCTTCCCTGAAATCATCTGTTCTGAGTACTGGAAATCAGCTC CTTCGACTAAAAAAGGTGGACACAGCCACGCTGCGCTCTGAGCTGTCGCGCATTGATAGCCAGTGGACTGACCTGCTAACCAATATCCCAGCCGTCCAGG AGAAGCTCCACCAGCTCCAGATGGATAAACTGCCTTCCCGCCATGCCATTTCTGAAGTCATGAGTTGGATTTCTCTAATGGAAAATGTTATTCAGAAGGA TGAAGATAATATTAAAAATTCCATAGGTTACAAGGCAATTCATGAATACCTTCAGAAATATAAGGGTTTTAAGATAGACATTAACTGTAAACAGCTGACA GTGGATTTTGTGAACCAGTCCGTGCTACAAATCAGCAGTCAGGATGTGGAAAGTAAGCGTAGTGATAAGACTGATTTTGCTGAGCAACTTGGAGCAATGA ATAAAAGTTGGCAAATTCTGCAAGGTCTAGTAACTGAGAAGATCCAGCTGTTGGAAGGCTTATTGGAATCTTGGTCAGAATATGAAAATAATGTACAATG TCTGAAAACATGGTTTGAAACCCAGGAAAAGAGACTAAAACAACAGCATCGAATTGGAGATCAGGCTTCTGTTCAAAATGCACTGAAAGACTGTCAGGAT CTGGAAGATTTGATTAAAGCAAAAGAAAAAGAAGTAGAGAAAATTGAGCAGAATGGACTTGCTTTGATTCAGAACAAGAAAGAAGACGTCTCTAGCATTG TCATGAGCACACTGCGAGAGCTCGGCCAAACCTGGGCAAATTTAGATCACATGGTTGGACAATTAAAGATACTGCTGAAATCAGTGCTTGACCAATGGAG TAGTCACAAAGTGGCCTTTGACAAGATAAACAGTTACCTCATGGAGGCCAGATACTCTCTTTCCCGATTCCGTCTGCTGACTGGCTCCTTAGAAGCTGTG CAAGTTCAGGTGGACAATCTTCAGAATCTCCAAGATGATCTGGAAAAACAGGAAAGGAGCTTACAGAAATTTGGCTCTATCACCAACCAATTATTAAAAG AGTGTCACCCACCCGTGACAGAAACTCTTACCAATACACTGAAAGAAGTCAACATGAGATGGAATAACTTGCTGGAAGAGATTGCTGAGCAGCTACAGTC CAGCAAGGCCCTACTTCAGCTTTGGCAAAGATACAAGGACTACTCCAAACAGTGTGCTTCGACAGTTCAGCAGCAGGAGGATCGAACCAATGAGCTGTTG AAGGCAGCCACAAACAAGGACATTGCCGATGATGAGGTTGCCACATGGATTCAAGATTGCAACGACCTCCTCAAAGGACTGGGCACAGTTAAAGATTCCC TCTTTTTTCTCCATGAGCTGGGAGAGCAACTGAAGCAACAAGTGGATGCTTCCGCAGCATCAGCTATTCAATCGGATCAACTCTCTTTGAGTCAACACTT GTGTGCCCTGGAGCAAGCTCTCTGCAAACAGCAGACTTCATTACAGGCTGGAGTTCTTGATTATGAAACCTTTGCCAAGAGTTTAGAAGCTTTGGAGGCC TGGATAGTGGAAGCTGAAGAAATACTACAAGGGCAGGACCCTAGCCACTCATCTGACCTCTCCACAATCCAGGAAAGGATGGAAGAACTTAAGGGACAGA TGTTAAAATTCAGCAGCATGGCTCCAGATTTAGACCGTCTAAATGAGCTTGGATATAGGTTACCCTTGAATGATAAGGAAATCAAAAGAATGCAGAATCT GAACCGCCATTGGTCTCTGATCTCCTCTCAGACTACAGAAAGATTCAGCAAGTTGCAGTCATTTTTGCTACAACATCAGACTTTCTTGGAAAAATGTGAA ACATGGATGGAATTCCTAGTTCAGACAGAACAAAAGTTAGCAGTAGAGATTTCAGGAAATTATCAGCACCTTTTGGAACAGCAGAGAGCACACGAGTTGT TTCAAGCCGAGATGTTCAGTCGTCAGCAGATTTTGCACTCAATCATTATTGATGGGCAACGTCTTCTAGAACAAGGTCAAGTTGATGACAGGGATGAATT CAACCTGAAATTGACACTCCTCAGTAATCAATGGCAGGGAGTGATTCGCAGGGCCCAGCAGAGGCGGGGGATCATTGACAGCCAGATTCGCCAGTGGCAG CGCTATAGGGAGATGGCAGAAAAGCTTCGTAAATGGTTGGTTGAAGTGTCCTACCTCCCCATGAGTGGTCTCGGAAGTGTTCCTATACCACTGCAACAAG CAAGGACCCTCTTTGATGAAGTGCAGTTCAAAGAAAAAGTGTTTCTGCGGCAACAAGGCAGCTACATCCTGACTGTGGAGGCTGGCAAGCAACTCCTTCT CTCGGCGGACAGTGGCGCTGAGGCCGCCTTGCAGGCCGAACTCGCTGAAATCCAAGAGAAATGGAAATCAGCCAGCATGCGGCTGGAAGAACAGAAGAAA AAACTAGCCTTCTTGTTGAAAGACTGGGAAAAATGTGAGAAAGGAATAGCAGATTCCCTGGAGAAACTACGAACTTTCAAAAAGAAGCTTTCGCAGTCTC TCCCGGATCACCATGAAGAGCTCCATGCAGAACAAATGCGTTGCAAGGAATTAGAAAATGCAGTTGGGAGCTGGACAGATGACTTGACCCAGTTGAGCCT GCTGAAGGACACCCTCTCTGCCTATATCAGTGCTGATGATATCTCCATTCTTAATGAACGCGTAGAGCTTCTGCAAAGGCAGTGGGAAGAACTATGCCAC CAGCTCTCCTTAAGGCGGCAGCAAATAGGTGAAAGATTGAATGAATGGGCAGTCTTCAGTGAAAAGAACAAGGAACTCTGTGAGTGGTTGACTCAAATGG AAAGCAAAGTTTCTCAGAATGGAGACATTCTCATTGAAGAAATGATAGAGAAGCTCAAGAAGGATTATCAAGAGGAAATTGCTATTGCTCAAGAGAACAA AATACAGCTCCAACAAATGGGAGAACGACTTGCTAAAGCCAGCCATGAAAGCAAAGCATCTGAGATTGAATACAAGCTGGGAAAGGTCAACGACCGGTGG CAGCATCTCCTGGACCTCATTGCAGCCAGGGTGAAGAAGCTGAAGGAGACCCTGGTAGCCGTGCAGCAGCTTGATAAGAACATGAGCAGCCTGAGGACCT GGCTCGCTCACATCGAGTCAGAGCTGGCCAAGCCAATAGTCTACGATTCCTGTAACTCGGAAGAAATACAGAGAAAGCTTAATGAGCAGCAGGAGCTTCA GAGAGACATAGAGAAGCACAGTACAGGTGTTGCATCTGTCCTCAACCTGTGTGAAGTCCTGCTGCACGACTGTGACGCCTGTGCCACTGATGCCGAGTGT GACTCTATACAGCAGGCTACGAGAAACCTGGACCGGCGGTGGAGAAACATTTGTGCTATGTCCATGGAAAGGAGGCTGAAAATCGAAGAGACGTGGCGAT TGTGGCAGAAATTTCTGGATGACTATTCACGTTTTGAAGATTGGCTGAAGTCTTCAGAAAGGACAGCTGCTTTTCCCAGCTCTTCTGGGGTGATCTATAC AGTTGCCAAGGAAGAACTAAAGAAATTTGAGGCTTTCCAGCGACAGGTCCACGAGTGCCTGACGCAGCTGGAACTGATCAACAAGCAGTACCGCCGCCTG GCCAGGGAGAACCGCACTGATTCAGCATGTAGCCTCAAACAGATGGTTCACGAAGGCAACCAGAGATGGGACAACCTGCAAAAGCGTGTCACCTCCATCT TGCGCAGACTCAAGCATTTTATTGGCCAGCGTGAGGAGTTTGAGACTGCGCGGGACAGCATTCTGGTCTGGCTCACAGAGATGGATCTGCAGCTCACTAA TATTGAACATTTTTCTGAGTGTGATGTTCAAGCTAAAATAAAGCAACTCAAGGCCTTCCAGCAGGAAATTTCACTGAACCACAATAAGATTGAGCAGATA ATTGCCCAAGGAGAACAGCTGATAGAAAAGAGTGAGCCCTTGGATGCAGCGATCATCGAGGAGGAACTAGATGAGCTCCGACGGTACTGCCAGGAGGTCT TCGGGCGTGTGGAAAGATACCATAAGAAACTGATCCGCCTGCCTCTCCCAGACGATGAGCACGACCTCTCAGACAGGGAGCTGGAGCTGGAAGACTCTGC AGCTCTGTCGGACCTGCACTGGCACGACCGCTCTGCAGACAGCCTGCTTTCTCCACAGCCTTCCTCCAATCTCTCCCTCTCGCTCGCTCAGCCCCTCCGG AGCGAGCGGTCAGGACGAGACACCCCGGCTAGTGTGGACTCCATCCCCCTGGAGTGGGATCACGACTATGACCTCAGTCGGGACCTGGAGTCTGCAATGT CCAGAGCTCTGCCCTCTGAGGATGAAGAAGGTCAGGATGACAAAGATTTCTACCTCCGGGGAGCTGTTGGCTTATCAGGGGACCACAGTGCCCTAGAGTC ACAGATCCGACAACTGGGCAAAGCCCTGGATGATAGCCGTTTTCAGATACAGCAAACCGAAAATATCATTCGCAGCAAAACTCCCACGGGGCCGGAGCTA GACACCAGCTACAAAGGCTACATGAAACTGCTGGGCGAATGCAGTAGCAGTATAGACTCCGTGAAGAGACTGGAGCACAAACTGAAGGAGGAAGAGGAGA GCCTTCCTGGCTTTGTTAACCTGCATAGTACCGAAACCCAAACGGCTGGTGTGATTGACCGATGGGAGCTTCTCCAGGCCCAGGCATTGAGCAAGGAGTT GAGGATGAAGCAGAACCTCCAGAAGTGGCAGCAGTTTAACTCAGACTTGAACAGCATCTGGGCCTGGCTGGGGGACACGGAGGAGGAGTTGGAACAGCTC CAGCGTCTGGAACTCAGCACTGACATCCAGACCATCGAGCTCCAGATCAAAAAGCTCAAGGAGCTCCAGAAAGCTGTGGACCACCGCAAAGCCATCATCC TCTCCATCAATCTCTGCAGCCCTGAGTTCACCCAGGCTGACAGCAAGGAGAGCCGGGACCTGCAGGATCGCTTGTCGCAGATGAATGGGCGCTGGGACCG AGTGTGCTCTCTGCTGGAGGAGTGGCGGGGCCTGCTGCAGGATGCCCTGATGCAGTGCCAGGGTTTCCATGAAATGAGCCATGGTTTGCTTCTTATGCTG GAGAACATTGACAGAAGGAAAAATGAAATTGTCCCTATTGATTCTAACCTTGATGCAGAGATACTTCAGGACCATCACAAACAGCTTATGCAAATAAAGC ATGAGCTGTTGGAATCCCAACTCAGAGTAGCCTCTTTGCAAGACATGTCTTGCCAACTACTGGTGAATGCTGAAGGAACAGACTGTTTAGAAGCCAAAGA AAAAGTCCATGTTATTGGAAATCGGCTCAAACTTCTCTTGAAGGAGGTCAGTCGTCATATCAAGGAACTGGAGAAGTTATTAGACGTGTCAAGTAGTCAG CAGGATTTGTCTTCCTGGTCTTCTGCTGATGAACTGGACACCTCAGGGTCTGTGAGTCCCACATCAGGAAGGAGCACCCCAAACAGACAGAAAACGCCAC GAGGCAAGTGTAGTCTCTCACAGCCTGGACCCTCTGTCAGCAGTCCACATAGCAGGTCCACAAAAGGTGGCTCCGATTCCTCCCTTTCTGAGCCAGGGCC AGGTCGGTCCGGCCGCGGCTTCCTGTTCAGAGTCCTCCGAGCAGCTCTTCCCCTTCAGCTTCTCCTGCTCCTCCTCATCGGGCTTGCCTGCCTTGTACCA ATGTCAGAGGAAGACTACAGCTGTGCCCTCTCCAACAACTTTGCCCGGTCATTCCACCCCATGCTCAGATACACGAATGGCCCTCCTCCACTCTGAACTA AGCAGATGCCATCTGCAGAAGTGCTGGTAGCATAAGGAGGATCGGGTCATAAGCAATCCCAAACTACCAACAAGAGGACCTTGATCTTGGCGAAAGCCCT CGGTGTGGCAGCTTTAGCCCTCCTCCAGATCACATGTGTGCAAATTATGGCTTCAGAGGTGGAAGATAAACAGTGACGGGGGAACAAACAGACAACAAGA AGGTTTGGAAGAAATCTGGTTTGAGACTCTGAACCTTAGCACTAAGGAGATTGAGTAAGGACCTCCAAAGTTCCCCGGACTCATGAATTCTGGGCCCTTG GCCCATTCTGTGCACAGCCAAGGACTTCAGTAGACCATCTGGGCAGCTTTCCCATGGTGCTGCTCCAACCATCAGATAAATGACCCTCCCAAGCACCATG TCAGTGTCGTACAATCTACCAACCAACCAGTGCTGAAGAGATTTTAGAACCTTGTAACATACAATTTTTAAGAGCTTATATGGCAGCTTCCTTTTTACCT TGTTTTCCTTTGGGGCATGATGTTTTAACCTTTGCTTTAGAAGCACAAGCTGTAAATCTAAAAGGCACTTTTTTTTAGAGGTATAAAGAAAAACTAGATG TAATAAATAAGATCATGGAAGGCTTTATGTGAAAAAAGTTGAATGTTATAGTAAAAAAAAAAAGATATTTATGTATGTACAGTTTGCTAAAGCCAAGTTT TGTTTGTATTGATTTCTTTGCATTTATTATAGATATTATAAAAT

refseq_SYNE1.F5 (forward primer)
refseq_SYNE1.R5 (reverse primer)
Single exon skipping

Frame 0

PGQWKPWAKVSWQDSAAPPGSGGSASRLSGTFP SHLDPREVVPV*RLAERVGHSTALQLRRNAQGRA SPGGRLGSRSPADRARSRRQGGRTAAHPRGPAE PGRREPGGSVRSLRLAAGKLNEAEREGS*VHVR GQS*NGRRKRSSSVFGRAASLLSAAKAWNSFMTE *I*KSPSMFSRVV*PCAASSEESLGVGFVLPEG PWQPPEGPPGVLGISPM*CRGCKMSKR*YKNEL SQNGSTLIWPSGNLQWWWTIFLKT*KMVLNCLPF WRSCLGRNCLVNKDAG*SESMLWLTLARHSSSS KEERLN*STLTPPI*LMADPQ*FLD*CGPLFYI SRLKS*PATCPSSSLCPAAHPPWTA*LALRLPAH QVNGR*PPRSKEMLRRLY*SGFSTQLASRLE*K *KILGRVGEAGLPFIQLFMPFDRNWWTWRQ*KA DPTEKIWRMLSLSPKQNWGSQDC*ILKTLMWINQ MRNLL*PM*PSF*NIILTSTMQALMGKRMMKYF QVSHLLQILYKILREKTE*FLRK*KFG*NNLRE I*QEHRWWNQIYRINISHLSTSEFNMK*RGNRLN I*YNHYTETVNCHLTKHW*NNLGIE*PPGSLTG IYSLINLFLHLWAP*VPGCTERRWP*ERK*PFN RSTRKQQTRYNGNLSNIRICFKTRMPTKEHSMKS TGPGLLTGFQCHLIN*RTWPRGFILFPPHQSYT **KWNF*N*STVCSHCWFLQSQS*SLGSLSTGG ESQWSSFYKTTCLL*KIASSLNNMR*HTRS*NRQ LRCMSKQMVQWKKLRM**NS*MKPPLSGGISQ* K*GV*GACWKK*SLTGIAMAIQWLVCKPG*RML KKCSINQKMPKRIFFEIYLIGFSSILP*TMLAIF *LKPVMRWFPVT*SSNYCC*MGGGGSCLWKSSN MLKLMRWTE*RRNTQTVLLPCLLLQRKPIRNFL NP*KSLL*MSSY*FKTWRILSRGCL*WMPNTR*L QRQHTSLPKKAPKKKEKKCLRPCQSSKSS*PRS KNVTPHSFMSLSSC*FRWRN*KSR*RPFMTHLG KSMKLSQFLSVRHNRVPFLNKNIRNC*LVKKTVR KP*HLLRKAVKVFKSL*P*ATC*SILIRRGYKD RLQIFMLLFRVW*RKLEIGRSMWKPTVA**RSL RSLEQSWRRYCGLLRRAWRKRGIQRSSCGDTLSF SVSWIRGCSMLS*KLVMNSPTSFQSRSSRGCRK LFESSTNNGRIFKEKPLIICFI*RLMWRRIGS* PL*KNAELSWIERPS*CPRKAVKR*LKSTGFSSV TKVLIISVRKGYSSSRNSV*NSQCGTQ*GTHLE PVT*LSKSSELPLTAPTGSSWKTQTSGRTTLAD SLSSHLGYLQMRHN*RGSRVRPSILPTTERLNVP LKRSEMVLPKGVRPSAG*NPG*KF*QKFLLRMK PKSREMSWQNYPALSRLL*RCCQRLKRC*AILG TVSSTKK*SKILSKN*FLALKKSRNKLRRSWILK ICLKHSSYFFITSKRQSGSQQRREMCSSRSRRR SREKGGCLTEATRSCGSWRAHWMAWSAAGRGRN AASRSH*ENGSDLKQTKKQ**DTFFKQVPVMNAS *VLAVWKVYLQNWNKQRSFLNGQKVLQSRLRTL *RKLQRYRLGPKISSCFNSRPSQSKNKSKN*KT RLKKILKPWKW*KPSGIILAVILRLCPSG*LRKK KNSMPWKLRHLPWTCKSAKLRSQFRK*KVSSAA L*D*KKKPSLLLSLLPLENLLELKPS*HK*EDT GKSFESMHSVWKEQSWDIYLSSKSLKRTLERSSN LCLNLKINLLFQLKYVLQLQKHTKFFKNIWISA RPWSH*AARSLPSQPVPGRL*TEIPVFRRLRLY SSNTRTS*GGRRRDRRRWRICWPTGRG*RKNYHP F*PG*SGVKLKPVPQKWTFLQTESKWKVNFS*Y RHCKMKLYPRPHSIANFCN*RNHCSQ*PPKMM* K**NYIWSSWMRDGEIYHRSLTKGLIFFSLWLLN TSNLMSCCFPFLSGLNCFSVNYKLPLRLA*WTI K*PLLGIRTTQQK*RAKRANCRVCRVT*QSWVL WAVLRTSTSCRERLRTASSCLRRPARLWRGGSLP CPIWQNSSRAMPLCPAFSAS*GKQWKQPTV*IR TSLI**KRTSMMLFKMLKH*NLLPSVWMAFFPK PNTI*KSGALSKGLPAEPRLISSVER*RGSRTFW EPSRVRQMLWQC*KKHSKTRKRSF*KALRTLKK GLTKSD*KNLPAKLFSRG*ECLIS*KMN*ILTS MNYVG*KTKPSKLPRKM*LLHLKLTGR*TA*RSP GMIPKD*FMKIRVSAVDLLT**ENIRT*NQLYL KS*KMPAV*L*PELP*KIRRILNGLFPSMKLPR TK*ITNRKTWITLPAKENTCYLS*RKFTVVISAW *KQTWRAPWTNGWMYQRNLKKTWIG*E*ACPFG MMYCQLEMRLRDGQTTAFHRWQKTSATWITTSE LKNCLKNLSLKLKTKH*DWKNCIPKLMI*KN*LK I*KHRQTFSL*KQT*CRNWSMPKK*LK*QKEP* RISRLKVHKWRSLLMT*QHGSQKWKNR**TVPK MRLVKH*KKSRIYKKNFKVNKATSALPKKISIAC AASTTQLSWRAWAVQ*LV**RNMKP*ASCAPKP RPACRNLWKNTSVSLCRNSKNGFWEQRQQQKNH QIAPVTAKF*KQSSMIFRTFWTQSVMGRANLMQ* LKKDKLCMHICLNKLSVAFKNKSQRPMKSFKHF *NNALKISRLFKTVLQNLEALKISTEN*TYGSM KWKKGSIRKTWERVNSTFLRRKMKFIKLKCFWEN CWLQESLLISFPREGSF*VKKATVLGRRAACVP SSSQATRTYLE*PKRNSGAARWPFRSTKPWRKH CKACGSG*RPFRTDWPVQRALLGAKTPWRNGCHK YRIFS**KVKGKLS*IWPLARGNRP*EVATKKV RG*FRLS*RPLKKCGLTS*APPSTLKAL*SL*L ANGMTM*RGKTSWSSGWNQWIKK*NIPYNHSQV* KRSSSCLTTSSPSCLRQKITREPFTV*LRSPGS STKRQRMSLSRTQLKRS*KHSLMI**LLPRKK* GKWKRL*KII*CI*MRSTSSQIGSIQQRKNFTGG QICLEIHQPPRKSYQKLRS**IPERLVQAVSAE WSRWLPK*NRTQLPVGVSSCTRRCRPCVPTGSS GKTVYSKRRAVWRTWSARWPFRSRNSQAKWLNWS RPWNSSVPF*KPGLSS*PSWKARTRMRR*WNAG TKDKRYWMLCKKQSLEQRISSLS*MNFVDFPET *VPTVEKFLA*LKSIIVFVCKHPRAARIKNRFYS KDFERPSGISSSGWLMQKSLPPSVLIYLKI*VK FQLVFRKYRSFCQKVKMDSTS*T*CCLKGNF*V PC*PKRKRKGSRPKLQLQKKIGKIFIQISTKKNL L*RI*RSK*RTLK*VLSLSRTG*VKLRRWSMKA AIASMICQQRGGSSRSSSLSLRKYTATSLSSTG *KRKLSSCGKDKLPARALGTECRSCLLSI*R*AI *QRRKCQDWIESLQNTISSLLGLKNYKTG*RMR FTCWIHTATRHPTKVCWTAGRSSSRLYYQSNRK KRFR*K***PGENLSFRILLQKAFPLFSSSCRV* RICGHPFCLQGFVVKANSKELSPSGQVIRMAFD SSPVGWIVWKPT*MNQKGSMRSCGIKQRCSEKP SY*MKKC*VTAACWRPSKSKGLA*QNTMSPS*NS RIYRNDTEPSKRGPRKP*PSLKNLSACTKSIRE T*RHLKFGWGKNKKSSTSIQFLKVMPTLMRQHC VIFRSYRYTVQRGRPC*TQCCTPERM*SHQVSHR QRTGL*SLSGKTGRLTSTGCPRLELSSITW*TN *G*WSKSFSK*MNGSKQQRRKLVPGPDVSLTGQ PRRYNYIR*RSGTKK*LHTEMKLRKWELELRRYW TRAT*TAEWVARPPS*LPDTRPCFSKCWNK*NS WRRRFRVWRNQNHPSVPILIGMALLIKTSRMWL PRLTK*IQ**WGRN*RRWRFCSKTWRKVTVC*NQ PGRKERGLLNTWRKARQRG*ERRFMITWSS*RN *PALSGKNT*RWKKVFI*QRNSQINAKH*HSG* QNTRKFYMFLKNPKWNYMRKKLSYLNTSHFNKRC CPMNHQ*SQ*ERRVKLFWNWCRTSL*RTK*INF KVITRTCAA*ERSMSSVWRRKSKTMKTTTVSSK RSKSGCCRCLADWWHLTSWRQAAWRQSPSNWPTT RQ*WKKLLVLKTV*TIFK*KVIL*LANVQTTCK RNLNKTCMLICRAQRTATQRSAAQLRGCTRVWN TNFRSTSADKTPCSSARPGFLQSSRI*SQVLNHL LVGQKPLSRSNTSELCKSRQGPT*ISFAPCVTC QMLR*KPQQKTFNKQSKRLNKSLSRPRT*LRAG KRSST*SLSSGFTCKMLISNCRT*RGGTLSWS*T LHRTWFHKLRILLRNYRANRHP*TP**KR*IS* QRRRNRLNTRK*II*MISGSICAVSLTTCACKG KRIFREQEITMTV*MLLKCS*KNLLQNGITWPDL MQRVQLSTWKL*KS*HWHCRRESMLLKI*KIKS RK**SI*I*MTRS*SKNRRVI*SNVGFSLRTSL KGKSKCQSPTWRS*MWCSPDFRS*WSGQKSNNPT SPRPLSRALLQIWLRTFSWITWPSAVNWRPSRC S*NRL*RTQTGSWQILVSMSDRSSRRLSLMHKA T*IVSVT*WASEEST*TKPCPRKPSFSWQCSRPP AKFSNMSER*CSVNTSVCYQMM*ANKSKHVRVH KPASRLTKMKSLDFGPRVAN**RKSQSRKRVKC WGSFRNCRVSMTVFYKSAVTGYKN*RRIWFLGSI LRKILIKLATG*NKQILLHFLKST**MRVLSFI HNWLNTKTFLNNLQNMKIFYLRCRELGRPYYHR *MKSIIPTSVKS*MLCLDNLM*LLPWLKTSSIKS RKQFLLGRNMLP*LS*QPSL*VNLKPNS*G*AK FPPTWPLRRLFLCKMVAEPFWTRWRALGRRWMN *TRKKKVFAAQVSLGSQTRCCTLSPYITG*SDKQ NRGLAY*KTPPVLTKNTRRCANSWRDN*SL*KR SSPK*MRKRCLQRRSSKCITPWQEVSRTQGLY* NE*PYILKILPHTLTPWLMRKPGIRSSPGKGS*N C*LLPLVRR*QNVRAEWCRV*TSRLR*VAPWTG *GE*RQSSVGRCT*TSTCRTSKRKSEKSKFIRK RSSPA*ES*MR*VTRKRRSSQRPRS*FLRI*NTA SLSSQSWMETSRKPYAPDRLP*LKYIASVKGII RYFKQPMTGLRMPKNCYSWQAMA*TWRAQRKIS KATWNFSVQRISSIVTWRSSTAW*PPWTHSSSQP AKKT*NRKWLLWNSGARG*AGTLVPKWISCRDA QLNGTITRKQGKRLLN**MIQKRNCLSFLC*RL RLVMKRKKNCQNTRL*CQWLTLSMRKLWPLRKKL HNWRKPEMMPAKPP*AGQ*PPSGSAGHAFELWP RTRRRSWKMQWMSGRALTTRLKRPLK*LISCKI SYLEVQQRKHRKQSS*LFLNTTTRSFWSWSSSSR PWACCGSKP*ACSRMEPPQPLGKSLRSCRKSPP CKIGA*TCRRK*RLMESW*SKS*RTEKWWRLRS IL*NVGFRKRKNI*GIQQ*K*MLNLKNFRFS*QK PQITDRTLKKWQKNRRRST*VFIPYYLLNSPFS WLKWR*I*RSEIRSKTK*KKLSRARPRARNSAG KFRS*LKTSQLF*LS*KRRQIM*FKLKLTKRCWE RN*MAVIQS*WN*MQQYRNSWNRMANWVSHWPR R*EN*LNFTSRPLDKLRIGSPSSIRQHHI*KNT MKCLN*F*SGLKKLKSWLMELLHGILQASFGNNI FCIRPC*KNPKKLTVSWKQ*LRNYSTSLACTVQ KKCLSKWQNWDGRLRSCDR*SKFVCRTSKMQLR I*KNLKQS*KSYKLPWSKPRQH*LLQKLDVSVSR SSSLIGSICCLRWSH*SRRCKQCSSARVPSGSP RMWLPAYLSVMLLCGCRKRPAGCSTPPSSSVTS CRQLWYNMNNMSKK*NISSN**KELTERLRINLL PPVTYRSCRLRFLGMRSWRRKLRATRSRSLL*I PSARC*R*KPSTPPCC*R*PRSRGWRKGQRTWM GSSSPRLRPTPLWS**LQVAVTLCCHRSLRSLGR REPTVRFPLHLPVAPLHLWLIQMLLLTRTLHIT KPCLLRGCRQMLQKFTPAHPHPRSSMNRDWSHP LLPNWVICSVLGKP*RM*SVRSSAHSMKLWNASR STRTPSSPSLRRWRPLS*NSVRAQSLAGVQKAR WLNIRH*WMRFSCSRMKSMSSSPLSQRSWYPSL VRPTLRSSWPCSPRSLS*PSECPPSG*KPRGNGS FWRRS*MISWRNKGRNRPCRGIAVKPMSWTAGS *VPRPLWTLR*VHPRSPWTWRPSLWTARICWWK *SRRWWLYQNCQSTMRTCCWRAKLTPRTRPSSWL ES*EGSRGACWSCREPCMISSSTCREQHRRRRR AMLT*QPRRAPASRNGWPKLAPHGPSSGRAVSS NKKS*NRN*PSRRVSFAQ*PVVERRF*FNIRRQR PLVMLAKNLMCYPRSWGWKGRNHPLKTR*E*NG KAYIKNLVPSRNYYRMFWNRNKSKCFIAGQIDS CLVCHCTKGTCQPKINLQLHLCWMD*TKPSRRFH PRVEGQRGRVYTWSRSCMMESQPPLLGWMTLKN VYLLPQHFYQKKQRLVSSTKRFLPKTLRKCLKK WIRTKTCFPKLFQRMVIIEMLLKILWVVFWAGYP C*TQ**INDVIR*KKDFSKY*ISRMI*KCCLHH WLTTNTSFCKNWQMCLNSP*QNK*RQYNRLKMD SKNLMQESLN*RGVVTSYRSSSRPCKNSPSSRTC MMS***SLAPGGVV*IRTLHSRVSMRGPYKIWL TC*KLVRRRWQETRKSSCLPKRKSSNYLTNIRN TFRAWNLI*S*LKHSSER*SALQSKRKPSSIQS* WLRLLLY*NGLTRGVWSWSTF*RRGPIWMRTSR SSADSWRWWKAASQAWVWWRRTRTGLLTA*HST SI*NLALMNTSPNYIKY*MMGNDF*YPSAAQI*K AN*INLESAG*VTPIKCLRNFTDWKQY*NTGPD IKVNLQI*FTGYNLQKTG*NFGLSNL*QSHKSW KWSVII*MLSWSFLKKWMPNLP*NHLF*VLEISS FD*KRWTQPRCALSCRALIASGLTC*PISQPSR RSSTSSRWINCLPAMPFLKS*VGFL*WKMLFRR MKIILKIP*VTRQFMNTFRNIRVLR*TLTVNS*Q WIL*TSPCYKSAVRMWKVSVVIRLILLSNLEQ* IKVGKFCKV**LRRSSCWKAYWNLGQNMKIMYN V*KHGLKPRKRD*NNSIELEIRLLFKMH*KTVRI WKI*LKQKKKK*RKLSRMDLL*FRTRKKTSLAL S*AHCESSAKPGQI*ITWLDN*RYC*NQCLTNG VVTKWPLTR*TVTSWRPDTLFPDSVC*LAP*KLC KFRWTIFRISKMIWKNRKGAYRNLALSPTNY*K SVTHP*QKLLPIH*KKST*DGITCWKRLLSSYS PARPYFSFGKDTRTTPNSVLRQFSSRRIEPMSC* RQPQTRTLPMMRLPHGFKIATTSSKDWAQLKIP SFFSMSWESN*SNKWMLPQHQLFNRINSL*VNT CVPWSKLSANSRLHYRLEFLIMKPLPRV*KLWRP G*WKLKKYYKGRTLATHLTSPQSRKGWKNLRDR C*NSAAWLQI*TV*MSLDIGYP*MIRKSKECRI *TAIGL*SPLRLQKDSASCSHFCYNIRLSWKNVK HGWNS*FRQNKS*Q*RFQEIISTFWNSREHTSC FKPRCSVVSRFCTQSLLMGNVF*NKVKLMTGMN ST*N*HSSVINGRE*FAGPSRGGGSLTARFASGS AIGRWQKSFVNGWLKCPTSP*VVSEVFLYHCNK QGPSLMKCSSKKKCFCGNKAATS*LWRLASNSF SRRTVALRPPCRPNSLKSKRNGNQPACGWKNRRK N*PSC*KTGKNVRKE*QIPWRNYELSKRSFRSL SRITMKSSMQNKCVARN*KMQLGAGQMT*PS*A C*RTPSLPISVLMISPFLMNA*SFCKGSGKNYAT SSP*GGSK*VKD*MNGQSSVKRTRNSVSG*LKW KAKFLRMETFSLKK**RSSRRIIKRKLLLLKRT KYSSNKWENDLLKPAMKAKHLRLNTSWERSTTGG SISWTSLQPG*RS*RRPW*PCSSLIRT*AA*GP GSLTSSQSWPSQ*STIPVTRKKYRESLMSSRSF RET*RSTVQVLHLSSTCVKSCCTTVTPVPLMPSV TLYSRLRETWTGGGETFVLCPWKGG*KSKRRGD CGRNFWMTIHVLKIG*SLQKGQLLFPALLG*SI QLPRKN*RNLRLSSDRSTSA*RSWN*STSSTAAW PGRTALIQHVASNRWFTKATRDGTTCKSVSPPS CADSSILLASVRSLRLRGTAFWSGSQRWICSSL ILNIFLSVMFKLK*SNSRPSSRKFH*TTIRLSR* LPKENS**KRVSPWMQRSSRRN*MSSDGTARRS SGVWKDTIRN*SACLSQTMSTTSQTGSWSWKTL QLCRTCTGTTALQTACFLHSLPPISPSRSLSPSG ASGQDETPRLVWTPSPWSGITTMTSVGTWSLQC PELCPLRMKKVRMTKISTSGELLAYQGTTVP*S HRSDNWAKPWMIAVFRYSKPKISFAAKLPRGRS* TPATKAT*NCWANAVAV*TP*RDWSTN*RRKRR AFLALLTCIVPKPKRLV*LTDGSFSRPRH*ARS *G*SRTSRSGSSLTQT*TASGPGWGTRRRSWNSS SVWNSALTSRPSSSRSKSSRSSRKLWTTAKPSS SPSISAALSSPRLTARRAGTCRIACRR*MGAGT ECALCWRSGGACCRMP*CSARVSMK*AMVCFLCW RTLTEGKMKLSLLILTLMQRYFRTITNSLCK*S MSCWNPNSE*PLCKTCLANYW*MLKEQTV*KPK KKSMLLEIGSNFS*RRSVVISRNWRSY*TCQVVS RICLPGLLLMNWTPQGL*VPHQEGAPQTDRKRH EASVVSHSLDPLSAVHIAGPQKVAPIPPFLSQG QVGPAAASCSESSEQLFPFSFSCSSSSGLPALYQ CQRKTTAVPSPTTLPGHSTPCSDTRMALLHSEL SRCHLQKCW*HKEDRVISNPKLPTRGP*SWRKP SVWQL*PSSRSHVCKLWLQRWKINSDGGTNRQQE GLEEIWFETLNLSTKEIE*GPPKFPGLMNSGPL AHSVHSQGLQ*TIWAAFPWCCSNHQINDPPKHH VSVVQSTNQPVLKRF*NLVTYNF*ELIWQLPFYL VFLWGMMF*PLL*KHKL*I*KALFFRGIKKN*M **IRSWKALCEKS*ML**KKKDIYVCTVC*SQV LFVLISLHLL*IL*N

Frame 1

PGSGNRGQKLAGRTAQLLQAAEAARPGSQGHFL PTSTPGRWSRYKGSLSGWVTAQLCSCGETPKAV HLQEGGWAPAVLQTAPDPGDRAGGQPRIPGVPPS LGAESREEAFARFALLLGN*TRPREKVLEFM*E DSLKTEEEKEAVQSLGELPPC*VLQRPGIHL*Q NRSRKVQACFLEWCSPVLPPVKSLLVLASCFRRD HGNLQRGLPVSSGYRQCDAEAAR*ARDSTKTNF HKMDQLSSGQAETSNGGGRSF*RHERWC*TACP SGGPVWAETAL*TRTPDEANPCCG*HWHGTQVPR RKKD*ISQH*LHRYS*WPTLNSSWIDVDHYSIF PD*RVDQQPAPAPVFVQQRILRGQHS*L*DSQP TK*TEGDHQDPRKC*EGFIKVGSVHSWQADWNRS KRFWEELEKRGCLSFSYSCHSTGIGGLGDSERQ IQPRKFGGCFHYRRNRTGDPKTARS*RR*CG*T R*EIYYDLCSPVSETLS*HPQCKH*WARG**NTS RFPIFCKFCTKF*ERRQSNF*GNESLDRTI*ER FDKSTDGGIKFTG*ISVI*ALQSSI*NEEETD* TFNTTITQRR*IVT*PSIGKTILG*SDLQAL*LA YTA**ISSCTSGHHRCLAVQSGGGPERGNNRST GPRGNSKHDTTET*AT*GSASKHGCPQKSIP*N LPDQVC*RDSSAT*SIRGHGREVSFCFLHIRATP NENGIFRIKVPSALTAGSCRVKAEVLDH*VREE RVSGAASTKLRVFYRK*QVL*TI*GDIPDLETD S*DVCQSRWFSGRS*ECDEIHE*NHRSVEESLSR SEECEEHAGRSDL*LGSLWQYSG*SASLARGC* KNAQSIRKCQKGFFSKFTSLDSAAYCHERCWQF SN*NL**DGFP*PEAAITVAKWAVEGVVYGSQAI CSS**DGQNEEGIHRLCCYPVCFCNGSP*ETF* TLRSLFYECQAINSRLGGY*AEGACDGCPIQDN YKDSTPHYQRKPPRRRKRNVCDHVKAQRAANQGQ RMLLPTPL*VSAAVDSVGGIRKADDVLL*LTWE NQ*NYHSS*A*GTIECPF*TKTSGTVSLSRKL* ENLDTY*ERQSKCSKVCDLEQRVKAF*SDEATKT DCRYSCCFSEYGKENWRLEEACGNQQSLDEEV* GVSSRVGEGTADCSGGPGGKGGSRGAPAETH*V FQSAGSEGAQCFPESL**THRHPSRAGAAGAAGS CSKAPQTMEGSSRRSPLSFASSED*CGEE*VLS LCRRMQN*AGSRDQADAPGRQ*KDN*RAQGFLQ *QRSSSSL*EKVTAHRGTLCETPSAGPSKGHTWN LSRDSQRAQSCH*QHLQEAHGRPRQVEGLH*QI L*VLILDIYK*DTIKGDQG*GHRYCQPRRG*TC R*RDQKWCYQKG*DPQLAEIQAESFDRSFF*E*S PKAGR*AGKIIQLFQGSCDAAVRG*KDAKQFWG LCPVQRNSQKFSRRINFWL*RSPGTS*EDLGY* KSV*STAVTSSSPAKDKADLSKEERCAAADRAGA AGRRGAA*PRPRGAAEAGEHTGWPGAQPGEAGT PHPGHIKKMGAI*NKQRNSSKIPFSNRFQS*TL LEF*QFGKFIFRTGTNKGVF*TDRKYCSPG*EPC KGSFRDTAWAPK*AAASTAGQVNQRTSQKIRRH A*RRY*NHGNGENQVGSFWQ*F*DSVRLDN*ER KRTQCLGNFVICHGHANQPN*GHNSGNRK*AQQH CRIRRRSPVFCSVCYHWRICSN*SQVDTNKKIR GRASRACTVSGRNNPGTFISAAKV*REP*KDPA ICV*I*R*TCCSN*NMFFSYRNIQSSSRTYGSLP GPGVTEQRDHCLLSQCQEGCEQRFLCSGGCGST AAIRGHPKEGEGETDGAGESAGPLAEARERTII LFDLVRAG*S*SQFPRNGHFCRQSQSGR*TSVNT GTAK*SCIPGLIL*QTFAIEGIIVLSSLQR*CE NDETTFGAVG*EMERFTTDH*QKD*FSSVCGC* TPAI**AAAFLFCLD*TVSQ*ITNYL*D*HNGPS SSPYSA*GPRSRSREQKGRIAESAGSLSKVGFS GPC*GPPPPAGKG*GLLPAV*GGQPGCGEAAAC PVPFGRIPPEPCLSVRHSPPAEANSGSNQQYE*E RV*FDRKGPQ*CSSKC*SIRICCRQSGWHSFQS PIPSENREL*AKDFLQSHG*SALWRGREDPEPS GNQAE*GRCSGSVEKSIPRPERGASEKH*GH*RK D*QRAIERTYPPSSSAEVKSV*SARR*IEFSRA *TMLVERQSQANCPERCSFCT*S*QGDKPLRGH LG*YQKTNS*KSGSVLWTY*LNERISEPEISCI* SLRKCQQCDCNQNYHKRSGGS*MGFFQA*NCQE QNELQTERLG*LYQQRKTLVI*AEENSQ**FQL GENRHGEHRGQMAGCIRET*RKHG*AESKPVHLG *CTVN*R*D*GMVKQLRSTDGRKHQQPG*PPQS *RTA*RI*V*S*KQSIEIGRTAFQS**SERIN* KSRNTARPSVYRSRLNAETGACQRNN*SSKRNPE GFHGSKYTSGEVY**HNNMVHKSGRIVDELCPK *DL*SIEKSQGYTKRTSKSTKQHQLYPRKSQ*L VPQVPLS*VGEPGPCNDWSDKET*SREPVVLQNP GQPAGISGKTLQ*VYAGIPRMVFGSKGSSKRII RSHR*QQSSRSKAP*SSEHFGLSQ*WAEQT*CS DSRRTNFVCTFV*TNCQ*HSRTNHKGQ*RVSSIS ETMP*R*AGSSRLCFRTWKL*RSAQKTELMDP* NGRKVQYGKLGRE*TAHS*EEK*SS*S*NVFGR TAGCKRVS**AFPERAASE*RRPRCWAGGPPVFP APHKPPEPT*NDQRETPELPGGPSGARSPGGST AKHVVLGEGHSGQTGLCREHSWEQRHPGETAVT NTGYSPDER*RGS*VEYGHWQGGTGLEK*QQRRS EGDSDSVRDP*RSVG*HHELLRPRSKHFRVCD* PME*LCREEKPVGAVDGISGSKNRTSLTTTARS EREVRPA*PPPVHPV*GRRSHESPSPSNCEVQGA LRKDRG*VFQGHSSRGAENTV**YNDCCQGKNE ESGRDCERSSNVFRCGPRVHRLAPFSKGRTSPV VRYVWRFISHPEKVIKN*GADRFQRDWCKPSQQS GVAGSRSETEHNCQWV*AHAHGDAGPACRLEAV GRQCIPNAELFGEPGQPDGPFGAGILRPSGSTG AGPGTVQCPSENLGSAVNPPGRQEHG*GDSGMLA QRTRDTGCFAKSRA*NRGSQVSAE*TLSIFQRP EYLQWKSFWLD*RV*LSLFASIQGLPE*RTDFT AKISKGLQGFPAVVG*CKNHYRQVF*YTSKYK*S FN*SSENTGVFVRK*KWTAQAKHDAV*RGTSEY PADQRESERDPGQSYSCKRRLEKFSFKSPPKRI CSRESKDPNEGL*SKC*AYPGLAE*N*EDGP*KQ QSPL*SASKEEGAAEAPVCP*GNTLLRASAQQA ERESSAAVGRTSCQQEL*AQSVAAVFSVSSAKQ FNKGESVKTG*NRCRTQSVLSWD*RITRLDDGCD SHAGFILPPDIRQKCAGQQDAQARGSIISQTGK RDSDENDSDQGRICPSEYFSRRHSHYSAAAAEC EGYVGIPFVCRDSL*KPTRRSSLQVDKLSGWRST VLRLDG*YGSQPE*IRKAACGAAG*NNDARKSQ VIK*RSAELQQLAGDHRSQRGWHDRTLCHPART PGSTGTIQSHPREGQGSRNQV*KTCPPAPRVSER PKGI*SLVGARTRKARPVFSS*R*CPHS*DNIA *SSGATGTLCRGAGPVELSAAHQRGCDPIRYPT GRGPGFRVSPARLAGLPAQAVRDSNSVQ*RGEQI EANGAKVSASR*MAQNSRGES*SQDQTSV*QGN QGDTITSDEEVARRSDCIQR*S*GSGS*SSGDT GREPREQQNGLPGHPADFQIPGPASPSAGTNKIP GGGDSEFGGIRIIPQFLF*LVWLYS*KLQECGY QD*QSRYSNDGEEIEDVGGFAQRHGERSQFAEI SPGERREGC*ILGGRRGREVKKGDS*SHGAVEGT DQHCPERTHDAGKRSSFSKGILR*MQSTDTVDS RIPGNSTCS*RTQNGII*EKSSVI*IQVTSTNG AVP*TISKVSEREG*SSFGTGAGRHFKGQNRSTS K*LPGPVQHRKGACLQSGGESQRP*RLQQ*APR GRKVAAADVWQTGGT*PPGDKQPGDNHPAIGPP QGNDGRNCWF*RPFEQSSNER*YFDWPMCRPPAS ET*TKRACSSAGHKGQLLSDLQHSSEDVPEFGT RTSEARQPTRHPAAVPGLAFCSPAGFRAKSSTT S**GRSH*AGQTLQSFARAGKDLPRSPLLHV*PV KCFGENHSKRHSTNRAND*TKACPGPELNSGLG RDQAPEV*ALDLPARC*SATAEHEEEAL*AGAE HCTEHGFTS*GFC*ETTEQTGIREHHNRKGE*VN KEGGIA*TQGNKSFK*SVARFVPSV*QPVLAKG RGSSENKRLP*LYECC*SVPRKIYYRMG*LGQI *CREYSCPPGSFEKVSIGIAGEKVCY*RSERSKA ENDRASEFR*QGVSQRTDESFRATLVSA*GPH* KENPSVSHQLGGVKCGAVQISGANGVGRRATTQ HRRGP*AEPSSRYGSEPSHGSPGHLQ*TGGQADA PEIAYKGRRQGHGRSWSQ*ATGHPEGSL*CTKP RELSQ*LSGPAKKVLKQSLVRENPVSHGSVPGH QPNSAT*AKDNVP*THLSVTR*CEQTSQNM*ECT SQPQDLPK*SHWTLGPGSRTNEGSHRAGKE*SA GEASGIAECL*QCFTKVQSPVTRTREEFGF*EA F*GRF**SLPLAKTSRYCYIS*NQPNE*EF*ASY TTG*IPKHS*TISRI*KSSTYAAENWADHITIA E*SRSFLPQ*KAKCFASTI*CNCCLG*RQVL*S PGSNSCSEGICFLD*VDNPVSE*T*SPILEDEQS SHRPGR*GGSFSARWLQSHSGRGGGPWGGGG*T EPEKRRFSQHRSALAARQDAAPCHLISQAEATN RTEG*LIRRHHQCLPRTREDVPTAGETTEVCKRG AVQSE*GNAACRGEAQNVSLPGRKSPGLRDCTE TSNHTS*RSCPTP*PLGL*ESQASDPVLARGVK TVDFCHW*DGDRM*EPNGAEYRLPD*DESLPGLA EESEGRAQWAGVPRPQPAGHPRGNQKNPNSSGR GPVQLENHECAESQGKGEVHKGQGADFCGFRTQ PR*ALRAGWRHPGSLTHQTGYLD*NI*PVSKVLS GISSSQ*LA*GCPRIVTAGRQWPRRGERRGKSQ KPHGIFQYRGSVP**PGGAPQPGSHPGPTHQAN RQRRPRTESGFSGTQEPEDEPGLWCPSGSLAEMH SSMARLPESKGRGY*IDE*YRKEIV*VFFVEDF V*S*SGRKIVRTQGFSVSG*LFP*ENCGP*GKS FTTGENRK*CQQSHPEQVNDHRLAALDTPSSCGP GPGEDPGRCSG*VDGL*QQG*KGH*ND*SAAR* VTWKFSRESIESRALNSS*IPRHVRSGAGAAAV GLGHAAAANPEHAPGWSRPNPWGRASAHAGNHRH ARSVPEHAGESED*WKVGEARAEGPRNGGDSDQ FCEMLGSGNERIFRESNNRNRCST*RTSDSPNR SHKSPTEH*KNGRRTEGEVLRSLYHITF*TLPSV G*SGVRSKDPRSDPRQNKRS*AEQGHEPGTQPA NSEVS*RPHNYSN*AESEDR*CSSS*N*PKGAG RGIRWL*FKVNGIRCSSTEILGTEWPTG*ATGQE DRKTD*TSPADH*TS*ESALQAQSGSITFRRIQ *NA*INFEVD*KS*SLGSWNYCMEFCKPASGTI YFASDPARRIQRN*Q*AGSND*EITVPH*RVLYR KNVSASGRTGTGD*GVATDDQNSFAEPPRCS*G YEKI*SRVEKVTSCLGASPGNTDFSRSWTSQSQ GAALSSAAFVV*DGVTEAEGASSAALPECPPDPR GCGCQLTSLSCCSAAAGRGQPAAAHRHPAV*HH AGSCGTI*TI*ARNETSPATDRRSSQRD*G*TC CHQ*HTGAAGSDFSA*GAGAEN*GLPGADRFFEF QVQDADDESQARHHAADGDRGRGAGGRDRGPGW GAPPHAFGPPLCGHDDCRSLSHFAVTGH*GVWG GGNQQ*DFLSTCLSLPFTCG*YRCFC*PGHCILP SLVC*EVADRCCKNSPQHIRIPGVL*TGIGAIR YCQTG*FAAFLGNLKECDQ*EAAHTL*SFGTPA EVPGLPPVHLYEDGGH*AETQ*EPRAWQESRKPD G*TSGIDG*DSHAPG*NQ*APVLSRRGAGIRVL *GRPCGAAGLAVHAHCLSRANVHHQDESLGETA AFGGEVE*SAGGTKAGTGPAEVSL*SR*AGQLAL EYQGHSGHCAESTQGAHGHGGPAYGLPEYAGGN RAEGGGFIRTVSPQ*EPAAGGQSSHQGRGRAAG WKAEKAQGEPAGAAESPA**AAQHAGNSTGEGGE RC*PNSHAEPRRPGMAGPSSHHMDPAAAEQSPA TKRVRTGISRAEESPSLSSQSWRGDSNSTFGGR DLW*CWRKT*CVIPGVGDGRGEIIR*RPDENEMG KPTSRI*YQAETTTECSGTGTRASAL*QAKSTL VWCATVQRGRANPR*ICSYIFAGWTEPSLRGGF IPEWRGKEAEYTLGAEVV*WSLSHLYLVG*R*RT FICCHSTFTRRNRDLSLQPRDSCQRH*GNV*RN G*EQKLVFPSFSREW**SRCY*RYFGLSFGQVI LARLSSESTMSSDERKTSANTKFPE*SESAVYIT G*QQIHHSAKTGKCV*TARSRTNRGNTTG*RWT QRI*CRNH*IKEAW*QATGRAAVHARTLQAPGH V**ADDDHWLPEEWSESEPYTQESV*EGPTRSG* PARNWSGEDGRRPENHRVFQRGNPATT*QT*GI LSGPGISYDLD*NTLQKDNQLCSPKGNPVPYRA DGSGFCCTETGSQEGCGAGVHSRDVVPSG*GPAG AQQTAGGGGKQHPKRGSGGGERGQAY*PHNTLP AFKI*P**IPAQIISSIR*WETTSDIHQLLRSR KPTKSTWRVLAK*HQ*NV*GTSQTGNNIETLDQI SK*ICRSNSLVTICKRPARILDSAICDSPTRAG NGP*SSKCFPGVF*RSGCPIFPEIICSEYWKSA PSTKKGGHSHAAL*AVAH**PVD*PANQYPSRPG EAPPAPDG*TAFPPCHF*SHELDFSNGKCYSEG *R*Y*KFHRLQGNS*IPSEI*GF*DRH*L*TAD SGFCEPVRATNQQSGCGK*A***D*FC*ATWSNE *KLANSARSSN*EDPAVGRLIGILVRI*K*CTM SENMV*NPGKETKTTASNWRSGFCSKCTERLSG SGRFD*SKRKRSREN*AEWTCFDSEQERRRL*HC HEHTARARPNLGKFRSHGWTIKDTAEISA*PME *SQSGL*QDKQLPHGGQILSFPIPSADWLLRSC ASSGGQSSESPR*SGKTGKELTEIWLYHQPIIKR VSPTRDRNSYQYTERSQHEME*LAGRDC*AATV QQGPTSALAKIQGLLQTVCFDSSAAGGSNQ*AV EGSHKQGHCR**GCHMDSRLQRPPQRTGHS*RFP LFSP*AGRATEATSGCFRSISYSIGSTLFESTL VCPGASSLQTADFITGWSS*L*NLCQEFRSFGG LDSGS*RNTTRAGP*PLI*PLHNPGKDGRT*GTD VKIQQHGSRFRPSK*AWI*VTLE**GNQKNAES EPPLVSDLLSDYRKIQQVAVIFATTSDFLGKM* NMDGIPSSDRTKVSSRDFRKLSAPFGTAESTRVV SSRDVQSSADFALNHY*WATSSRTRSS**QG*I QPEIDTPQ*SMAGSDSQGPAEAGDH*QPDSPVA AL*GDGRKAS*MVG*SVLPPHEWSRKCSYTTATS KDPL**SAVQRKSVSAATRQLHPDCGGWQATPS LGGQWR*GRLAGRTR*NPREMEISQHAAGRTEE KTSLLVERLGKM*ERNSRFPGETTNFQKEAFAVS PGSP*RAPCRTNALQGIRKCSWELDR*LDPVEP AEGHPLCLYQC**YLHS**TRRASAKAVGRTMP PALLKAAANR*KIE*MGSLQ*KEQGTL*VVDSNG KQSFSEWRHSH*RNDREAQEGLSRGNCYCSREQ NTAPTNGRTTC*SQP*KQSI*D*IQAGKGQRPV AASPGPHCSQGEEAEGDPGSRAAA**EHEQPEDL ARSHRVRAGQANSLRFL*LGRNTEKA**AAGAS ERHREAQYRCCICPQPV*SPAARL*RLCH*CRV *LYTAGYEKPGPAVEKHLCYVHGKEAENRRDVAI VAEISG*LFTF*RLAEVFRKDSCFSQLFWGDLY SCQGRTKEI*GFPATGPRVPDAAGTDQQAVPPP GQGEPH*FSM*PQTDGSRRQPEMGQPAKACHLHL AQTQAFYWPA*GV*DCAGQHSGLAHRDGSAAH* Y*TFF*V*CSS*NKATQGLPAGNFTEPQ*D*AD NCPRRTADRKE*ALGCSDHRGGTR*APTVLPGGL RACGKIP*ETDPPASPRR*ARPLRQGAGAGRLC SSVGPALARPLCRQPAFSTAFLQSLPLARSAPP ERAVRTRHPG*CGLHPPGVGSRL*PQSGPGVCNV QSSAL*G*RRSG*QRFLPPGSCWLIRGPQCPRV TDPTTGQSPG**PFSDTANRKYHSQQNSHGAGA RHQLQRLHETAGRMQ*QYRLREETGAQTEGGRGE PSWLC*PA*YRNPNGWCD*PMGASPGPGIEQGV EDEAEPPEVAAV*LRLEQHLGLAGGHGGGVGTA PASGTQH*HPDHRAPDQKAQGAPESCGPPQSHHP LHQSLQP*VHPG*QQGEPGPAGSLVADEWALGP SVLSAGGVAGPAAGCPDAVPGFP*NEPWFASYA GEH*QKEK*NCPY*F*P*CRDTSGPSQTAYANKA *AVGIPTQSSLFARHVLPTTGEC*RNRLFRSQR KSPCYWKSAQTSLEGGQSSYQGTGEVIRRVK*S AGFVFLVFC**TGHLRVCESHIRKEHPKQTENAT RQV*SLTAWTLCQQST*QVHKRWLRFLPF*ARA RSVRPRLPVQSPPSSSSPSASPAPPHRACLPCT NVRGRLQLCPLQQLCPVIPPHAQIHEWPSSTLN* ADAICRSAGSIRRIGS*AIPNYQQEDLDLGESP RCGSFSPPPDHMCANYGFRGGR*TVTGEQTDNK KVWKKSGLRL*TLALRRLSKDLQSSPDS*ILGPW PILCTAKDFSRPSGQLSHGAAPTIR*MTLPSTM SVSYNLPTNQC*RDFRTL*HTIFKSLYGSFLFT LFSFGA*CFNLCFRSTSCKSKRHFFLEV*RKTRC NK*DHGRLYVKKVECYSKKKKIFMYVQFAKAKF CLY*FLCIYYRYYK

Frame 2

RAVETVGKS*LAGQRSSSRQRRQRVPALRDISF PPRPPGGGPGIKAR*AGGSQHSFAAAEKRPRPC ISRRAAGLPQSCRPRPIPATGRADSRASPGSRR AWAQRAGRKRSLASPCCWETERGRERRFLSSCKR TVLKRKKKKKQFSLWESCLLVECCKGLEFIYDR IDLEKSKHVF*SGVALCCLQ*RVSWCWLRASGG TMATSRGASRCPRDIANVMQRLQDEQEIVQKRTF TKWINSHLAKRKPPMVVDDLFEDMKDGVKLLAL LEVLSGQKLPCEQGRRMKRIHAVANIGTALKFL EGRKIKLVNINSTDIADGRPSIVLGLMWTIILYF QIEELTSNLPQLQSLSSSASSVDSIVSSETPSP PSKRKVTTKIQGNAKKALLKWVQYTAGKQTGIE VKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGR SNRENLEDAFTIAETELGIPRLLDPEDVDVDKP DEKSIMTYVAQFLKHYPDIHNASTDGQEDDEIL PGFPSFANSVQNFKREDRVIFKEMKVWIEQFERD LTRAQMVESNLQDKYQSFKHFRVQYEMKRKQIE HLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDW HIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQ VHEETANTIQRKLEQHKDLLQNTDAHKRAFHEI YRTRSVNGIPVPPDQLEDMAERFHFVSSTSELH LMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRR ESVEQLLQNYVSFIENSKFFEQYEVTYQILKQT AEMYVKADGSVEEAENVMKFMNETTAQWRNLSV EVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAE KMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNF LIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQ YAQADEMDRMKKEYTDCVVTLSAFATEAHKKLSE PLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKII TKTAHLITKESPQEEGKEMFATMSKLKEQLTKV KECYSPLLYESQQLLIPLEELEKQMTSFYDSLGK INEIITVLEREAQSSALFKQKHQELLACQENCK KTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQR QIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFE ESRAELEKVLRIAQEGLEEKGDPEELLRRHTEF FSQLDQRVLNAFLKACDELTDILPEQEQQGLQE AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLA SVEECRTELDRETKLMPQEGSEKIIKEHRVFFS DKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPG TCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRF SEFSSWISTNETQLKGIKGEAIDTANHGEVKRA VEEIRNGVTKRGETLSWLKSRLKVLTEVSSENE AQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGD CVQYKEIVKNSLEELISGSKEVQEQAEKILDTE NLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQA QQGEGGLPDRGHEELRKLESTLDGLERSRERQER RIQVTLRKWERFETNKETVVRYLFQTGSSHERF LSFSSLESLSSELEQTKEFSKRTESIAVQAENL VKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDT LEEDIKTMEMVKTKWDHFGSNFETLSVWITEKE KELNALETSSSAMDMQISQIKVTIQEIESKLSS IVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYG EELREHAQCLEGTILGHLSQQQKFEENLRKIQQ SVSEFEDKLAVPIKICSSATETYKVLQEHMDLC QALESLSSAITAFSASARKVVNRDSCVQEAAALQ QQYEDILRRAKERQTALENLLAHWQRLEKELSS FLTWLERGEAKASSPEMDISADRVKVEGELQLI QALQNEVVSQASFYSKLLQLKESLFSVASKDDVK MMKLHLEQLDERWRDLPQIINKRINFLQSVVAE HQQFDELLLSFSVWIKLFLSELQTTSEISIMDH QVALTRHKDHAAEVESKKGELQSLQGHLAKLGSL GRAEDLHLLQGKAEDCFQLFEEASQVVERRQLA LSHLAEFLQSHASLSGILRQLRQTVEATNSMNK NESDLIEKDLNDALQNAKALESAAVSLDGILSKA QYHLKIGSSEQRTSCRATADQLCGEVERIQNLL GTKQSEADALAVLKKAFQDQKEELLKSIEDIEE RTDKERLKEPTRQALQQRLRVFNQLEDELNSHEH ELCWLKDKAKQIAQKDVAFAPEVDREINRLEVT WDDTKRLIHENQGQCCGLIDLMREYQNLKSAVS KVLENASSVIVTRTTIKDQEDLKWAFSKHETAKN KMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSL VKTDMESTVDKWLDVSEKLEENMDRLRVSLSIW DDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRA EELLKEFESEVKNKALRLEELHSKVNDLKELTK NLETPPDLQFIEADLMQKLEHAKEITEVAKGTL KDFTAQSTQVEKFINDITTWFTKVEESLMNCAQN ETCEALKKVKDIQKELQSQQSNISSTQENLNSL CRKYHSAELESLGRAMTGLIKKHEAVSQLCSKT QASLQESLEKHFSESMQEFQEWFLGAKAAAKESS DRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAV TQEGQTLYAHLSKQIVSSIQEQITKANEEFQAF LKQCLKDKQALQDCASELGSFEDQHRKLNLWIHE MEERFNTENLGESKQHIPEKKNEVHKVEMFLGE LLAARESLDKLSQRGQLLSEEGHGAGQEGRLCS QLLTSHQNLLRMTKEKLRSCQVALQEHEALEEAL QSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQ IQDILLMKGEGEVKLNMAIGKGEQALRSSNKEG QRVIQTQLETLKEVWADIMSSSVHAQSTLESVIS QWNDYVERKNQLEQWMESVDQKIEHPLQPQPGL KEKFVLLDHLQSILSEAEDHTRALHRLIAKSRE LYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMR KVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRW SDMSGDSSATQKKLSKIKELIDSREIGASRLSR VESLAPEVKQNTTASGCELMHTEMQALRADWKQW EDSVFQTQSCLENLVSQMALSEQEFSGQVAQLE QALEQFSALLKTWAQQLTLLEGKNTDEEIVECW HKGQEILDALQKAEPRTEDLKSQLNELCRFSRDL STYSGKVSGLIKEYNCLCLQASKGCQNKEQILQ QRFRKAFRDFQQWLVNAKITTAKCFDIPQNISE VSTSLQKIQEFLSESENGQHKLNMMLSKGELLST LLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKES ALENLKIQMKDFEVSAEPIQDWLSKTEKMVHES SNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRL KEKAQQLWEGQAASKSFRHRVSQLSSQYLALSN LTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDA IHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEK EIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSV KDMWASLLSAGIRCKSQLEGALSKWTSYQDGVR QFSGWMDSMEANLNESERQHAELRDKTTMLGKAK LLNEEVLSYSSLLETIEVKGAGMTEHYVTQLEL QDLQERYRAIQERAKEAVTKSEKLVRLHQEYQR DLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLR DLQELQVHCAEGQALLNSVLHTREDVIPSGIPQ AEDRALESLRQDWQAYQHRLSETRTQFNNVVNK LRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRAT KEIQLHQMKKWHEEVTAYRDEVEEVGARAQEIL DESHVNSRMGCQATQLTSRYQALLLQVLEQIKF LEEEIQSLEESESSLSSYSDWYGSTHKNFKNVAT KIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKS AREKGERAVKYLEEGEAERLRKEIHDHMEQLKE LTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIA EYQEILHVPEEPKMELYEKKAQLSKYKSLQQTV LSHEPSVKSVREKGEALLELVQDVTLKDKIDQL QSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQE VEKWLLQMSGRLVAPDLLETSSLETITQQLAHH KAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQ AKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEH ELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPP LSRAEAIKQVKHFRALQEQARTYLDLLCSMCDL SNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWE EIKHLKSELWIYLQDADQQLQNMKRRHSELELN IAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKL TKKEESPEHKEINHLNDQWLDLCRQSNNLCLQRE EDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARS DAESTAVHLEALKKLALALQERKYAIEDLKDQK QKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIK RKIQVSVTNLEELNVVQSRFQELMEWAEEQQPN IAEALKQSPPPDMAQNLLMDHLAICSELEAKQM LLKSLIKDADRVMADLGLNERQVIQKALSDAQSH VNCLSDLVGQRRKYLNKALSEKTQFLMAVFQAT SQIQQHERKIMFREHICLLPDDVSKQVKTCKSA QASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVL GKLQELQSVYDSVLQKCSHRLQELEKNLVSRKH FKEDFDKACHWLKQADIVTFPEINLMNESSELH TQLAKYQNILEQSPEYENLLLTLQRTGQTILPSL NEVDHSYLSEKLNALPRQFNVIVALAKDKFYKV QEAILARKEYASLIELTTQSLSELEAQFLRMSK VPTDLAVEEALSLQDGCRAILDEVAGLGEAVDEL NQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQT EQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKE EQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLK RVTIHLEDLAPHLDPLAYEKARHQIQSWQGELK LLTSAIGETVTECESRMVQSIDFQTEMSRSLDW LRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEE VQSSLRIMNALSHKEKEKFTKAKELISADLEHS LAELSELDGDIQEALRTRQATLTEIYSQCQRYY QVFQAANDWLEDAQELLQLAGNGLDVESAEENLK SHMEFFSTEDQFHSNLEELHSLVATLDPLIKPT GKEDLEQKVASLELRSQRMSRDSGAQVDLLQRC TAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTS SSHEAEEKLSEHKALVSVVNSFHEKIVALEEKA SQLEKTGNDASKATLSRSMTTVWQRWTRLRAVA QDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDK LPGSSAEKASKAELLTLLEYHDTFVLELEQQQS ALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITA MQDRCLNMQEKVKTNGKLVKQELKDREMVETQIN SVKCWVQETKEYLGNPTIEIDAQLEELQILLTE ATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQ LAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQ IQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLG EELDGCNSKLMELDAAVQKFLEQNGQLGKPLAK KIGKLTELHQQTIRQAENRLSKLNQAASHLEEYN EMLELILKWIEKAKVLAHGTIAWNSASQLREQY ILHQTLLEESKEIDSELEAMTEKLQYLTSVYCT EKMSQQVAELGRETEELRQMIKIRLQNLQDAAKD MKKFEAELKKLQAALEQAQATLTSPEVGRLSLK EQLSHRQHLLSEMESLKPKVQAVQLCQSALRIP EDVVASLPLCHAALRLQEEASRLQHTAIQQCNIM QAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPV ATSNIQELQAQISRHEELAQKIKGYQEQIASLN SKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDG ELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGE EGTNSEISSPPACRSPSPVANTDASVNQDIAYY QALSAERLQTDAAKIHPSTSASQEFYEPGLEPSA TAKLGDLQRSWETLKNVISEKQRTLYEALERQQ KYQDSLQSISTKMEAIELKLSESPEPGRSPESQ MAEHQALMDEILMLQDEINELQSSLAEELVSESC EADPAEQLALQSTLTVLAERMSTIRMKASGKRQ LLEEKLNDQLEEQRQEQALQRYRCEADELDSWL LSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEI EQKVVALSELSVHNENLLLEGKAHTKDEAEQLA GKLRRLKGSLLELQRALHDKQLNMQGTAQEKEE SDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQ QKELEQELAEQKSLLRSVASRGEEILIQHSAAE TSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKW ESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLL SGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVS SQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEE RLFVATALLPEETETCLFNQEILAKDIKEMSEEM DKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLS LLDSVVNQRCHQMKERLQQILNFQNDLKVLFTS LADNKYIILQKLANVFEQPVAEQIEAIQQAEDGL KEFDAGIIELKRRGDKLQVEQPSMQELSKLQDM YDELMMIIGSRRSGLNQNLTLKSQYERALQDLA DLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEY FQGLESHMILTETLFRKIISFAVQKETQFHTEL MAQASAVLKRAHKRGVELEYILETWSHLDEDQQ ELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQ HLKSSLNEYQPKLYQVLDDGKRLLISISCSDLE SQLNQLGECWLSNTNKMSKELHRLETILKHWTR YQSESADLIHWLQSAKDRLEFWTQQSVTVPQELE MVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQL LRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQ EKLHQLQMDKLPSRHAISEVMSWISLMENVIQKD EDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLT VDFVNQSVLQISSQDVESKRSDKTDFAEQLGAM NKSWQILQGLVTEKIQLLEGLLESWSEYENNVQC LKTWFETQEKRLKQQHRIGDQASVQNALKDCQD LEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSI VMSTLRELGQTWANLDHMVGQLKILLKSVLDQWS SHKVAFDKINSYLMEARYSLSRFRLLTGSLEAV QVQVDNLQNLQDDLEKQERSLQKFGSITNQLLK ECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQS SKALLQLWQRYKDYSKQCASTVQQQEDRTNELL KAATNKDIADDEVATWIQDCNDLLKGLGTVKDS LFFLHELGEQLKQQVDASAASAIQSDQLSLSQHL CALEQALCKQQTSLQAGVLDYETFAKSLEALEA WIVEAEEILQGQDPSHSSDLSTIQERMEELKGQ MLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNL NRHWSLISSQTTERFSKLQSFLLQHQTFLEKCE TWMEFLVQTEQKLAVEISGNYQHLLEQQRAHEL FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEF NLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQ RYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQ ARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLL SADSGAEAALQAELAEIQEKWKSASMRLEEQKK KLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS LPDHHEELHAEQMRCKELENAVGSWTDDLTQLSL LKDTLSAYISADDISILNERVELLQRQWEELCH QLSLRRQQIGERLNEWAVFSEKNKELCEWLTQM ESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENK IQLQQMGERLAKASHESKASEIEYKLGKVNDRW QHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQ RDIEKHSTGVASVLNLCEVLLHDCDACATDAEC DSIQQATRNLDRRWRNICAMSMERRLKIEETWR LWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT VAKEELKKFEAFQRQVHECLTQLELINKQYRRL ARENRTDSACSLKQMVHEGNQRWDNLQKRVTSI LRRLKHFIGQREEFETARDSILVWLTEMDLQLTN IEHFSECDVQAKIKQLKAFQQEISLNHNKIEQI IAQGEQLIEKSEPLDAAIIEEELDELRRYCQEV FGRVERYHKKLIRLPLPDDEHDLSDRELELEDSA ALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLR SERSGRDTPASVDSIPLEWDHDYDLSRDLESAM SRALPSEDEEGQDDKDFYLRGAVGLSGDHSALES QIRQLGKALDDSRFQIQQTENIIRSKTPTGPEL DTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEE SLPGFVNLHSTETQTAGVIDRWELLQAQALSKEL RMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQL QRLELSTDIQTIELQIKKLKELQKAVDHRKAII LSINLCSPEFTQADSKESRDLQDRLSQMNGRWDR VCSLLEEWRGLLQDALMQCQGFHEMSHGLLLML ENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIK HELLESQLRVASLQDMSCQLLVNAEGTDCLEAKE KVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQ QDLSSWSSADELDTSGSVSPTSGRSTPNRQKTP RGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGP GRSGRGFLFRVLRAALPLQLLLLLLIGLACLVP MSEEDYSCALSNNFARSFHPMLRYTNGPPPL*T KQMPSAEVLVA*GGSGHKQSQTTNKRTLILAKAL GVAALALLQITCVQIMASEVEDKQ*RGNKQTTR RFGRNLV*DSEP*H*GD*VRTSKVPRTHEFWAL GPFCAQPRTSVDHLGSFPMVLLQPSDK*PSQAPC QCRTIYQPTSAEEILEPCNIQFLRAYMAASFLP CFPLGHDVLTFALEAQAVNLKGTFF*RYKEKLD VINKIMEGFM*KKLNVIVKKKRYLCMYSLLKPSF VCIDFFAFIIDIIK

Sequence NM_015293

CAAAAATCAGTCTGATCTCGGGAAACCTGGAGAAATTTATTTTCTGTACTCTAATGTTCTTTCATTTTGGTGACCATCAAGGTGCTGGGAGAGGAATTAG ATGGCTGTAATTCAAAGTTAATGGAATTAGATGCAGCAGTACAGAAATTCTTGGAACAGAATGGCCAACTGGGTAAGCCACTGGCCAAGAAGATAGGAAA ACTGACTGAACTTCACCAGCAGACCATTAGACAAGCTGAGAATCGGCTCTCCAAGCTCAATCAGGCAGCATCACATTTAGAAGAATACAATGAAATGCTT GAATTAATTTTGAAGTGGATTGAAAAAGCTAAAGTCTTGGCTCATGGAACTATTGCATGGAATTCTGCAAGCCAGCTTCGGGAACAATATATTTTGCATC AGACCCTGCTAGAAGAATCCAAAGAAATTGACAGTGAGCTGGAAGCAATGACTGAGAAATTACAGTACCTCACTAGCGTGTACTGTACAGAAAAAATGTC TCAGCAAGTGGCAGAACTGGGACGGGAGACTGAGGAGTTGCGACAGATGATCAAAATTCGTTTGCAGAACCTCCAAGATGCAGCTAAGGATATGAAAAAA TTTGAAGCAGAGTTGAAAAAGTTACAAGCTGCCTTGGAGCAAGCCCAGGCAACACTGACTTCTCCAGAAGTTGGACGTCTCAGTCTCAAGGAGCAGCTCT CTCATCGGCAGCATTTGTTGTCTGAGATGGAGTCACTGAAGCCGAAGGTGCAAGCAGTGCAGCTCTGCCAGAGTGCCCTCCGGATCCCCGAGGATGTGGT TGCCAGCTTACCTCTCTGTCATGCTGCTCTGCGGCTGCAGGAAGAGGCCAGCCGGCTGCAGCACACCGCCATCCAGCAGTGTAACATCATGCAGGCAGCT GTGGTACAATATGAACAATATGAGCAAGAAATGAAACATCTCCAGCAACTGATAGAAGGAGCTCACAGAGAGATTGAGGATAAACCTGTTGCCACCAGTA ACATACAGGAGCTGCAGGCTCAGATTTCTCGGCATGAGGAGCTGGCGCAGAAAATTAAGGGCTACCAGGAGCAGATCGCTTCTTTGAATTCCAAGTGCAA GATGCTGACGATGAAAGCCAAGCACGCCACCATGCTGCTGACGGTGACCGAGGTCGAGGGGCTGGCGGAAGGGACAGAGGACCTGGATGGGGAGCTCCTC CCCACGCCTTCGGCCCACCCCTCTGTGGTCATGATGACTGCAGGTCGCTGTCACACTTTGCTGTCACCGGTCACTGAGGAGTCTGGGGAGGAGGGAACCA ACAGTGAGATTTCCTCTCCACCTGCCTGTCGCTCCCCTTCACCTGTGGCTAATACAGATGCTTCTGTTAACCAGGACATTGCATATTACCAAGCCTTGTC TGCTGAGAGGTTGCAGACAGATGCTGCAAAAATTCACCCCAGCACATCCGCATCCCAGGAGTTCTATGAACCGGGATTGGAGCCATCCGCTACTGCCAAA CTGGGTGATTTGCAGCGTTCTTGGGAAACCTTAAAGAATGTGATCAGTGAGAAGCAGCGCACACTCTATGAAGCTTTGGAACGCCAGCAGAAGTACCAGG ACTCCCTCCAGTCCATCTCTACGAAGATGGAGGCCATTGAGCTGAAACTCAGTGAGAGCCCAGAGCCTGGCAGGAGTCCAGAAAGCCAGATGGCTGAACA TCAGGCATTGATGGATGAGATTCTCATGCTCCAGGATGAAATCAATGAGCTCCAGTCCTCTCTCGCAGAGGAGCTGGTATCCGAGTCTTGTGAGGCCGAC CCTGCGGAGCAGCTGGCCTTGCAGTCCACGCTCACTGTCTTAGCCGAGCGAATGTCCACCATCAGGATGAAAGCCTCGGGGAAACGGCAGCTTTTGGAGG AGAAGTTGAATGATCAGCTGGAGGAACAAAGGCAGGAACAGGCCCTGCAGAGGTATCGCTGTGAAGCCGATGAGCTGGACAGCTGGCTCTTGAGTACCAA GGCCACTCTGGACACTGCGCTGAGTCCACCCAAGGAGCCCATGGACATGGAGGCCCAGCTTATGGACTGCCAGAATATGCTGGTGGAAATAGAGCAGAAG GTGGTGGCTTTATCAGAACTGTCAGTCCACAATGAGAACCTGCTGCTGGAGGGCAAAGCTCACACCAAGGACGAGGCCGAGCAGCTGGCTGGAAAGCTGA GAAGGCTCAAGGGGAGCCTGCTGGAGCTGCAGAGAGCCCTGCATGATAAGCAGCTCAACATGCAGGGAACAGCACAGGAGAAGGAGGAGAGCGATGTTGA CCTAACAGCCACGCAGAGCCCCGGCGTCCAGGAATGGCTGGCCCAAGCTCGCACCACATGGACCCAGCAGCGGCAGAGCAGTCTCCAGCAACAAAAAGAG TTAGAACAGGAATTAGCCGAGCAGAAGAGTCTCCTTCGCTCAGTAGCCAGTCGTGGAGAGGAGATTCTAATTCAACATTCGGCGGCAGAGACCTCTGGTG ATGCTGGCGAAAAACCTGATGTGTTATCCCAGGAGTTGGGGATGGAAGGGGAGAAATCATCCGCTGAAGACCAGATGAGAATGAAATGGGAAAGCCTACA TCAAGAATTTAGTACCAAGCAGAAACTACTACAGAATGTTCTGGAACAGGAACAAGAGCAAGTGCTTTATAGCAGGCCAAATCGACTCTTGTCTGGTGTG CCACTGTACAAAGGGGACGTGCCAACCCAAGATAAATCTGCAGTTACATCTTTGCTGGATGGACTGAACCAAGCCTTCGAGGAGGTTTCATCCCAGAGTG GAGGGGCAAAGAGGCAGAGTATACACTTGGAGCAGAAGTTGTATGATGGAGTCTCAGCCACCTCTACTTGGTTGGATGACGTTGAAGAACGTTTATTTGT TGCCACAGCACTTTTACCAGAAGAAACAGAGACTTGTCTCTTCAACCAAGAGATTCTTGCCAAAGACATTAAGGAAATGTCTGAAGAAATGGATAAGAAC AAAAACTTGTTTTCCCAAGCTTTTCCAGAGAATGGTGATAATCGAGATGTTATTGAAGATACTTTGGGTTGTCTTTTGGGCAGGTTATCCTTGCTAGACT CAGTAGTGAATCAACGATGTCATCAGATGAAAGAAAGACTTCAGCAAATACTAAATTTCCAGAATGATCTGAAAGTGCTGTTTACATCACTGGCTGACAA CAAATACATCATTCTGCAAAAACTGGCAAATGTGTTTGAACAGCCCGTAGCAGAACAAATAGAGGCAATACAACAGGCTGAAGATGGACTCAAAGAATTT GATGCAGGAATCATTGAATTAAAGAGGCGTGGTGACAAGCTACAGGTCGAGCAGCCGTCCATGCAAGAACTCTCCAAGCTCCAGGACATGTATGATGAGC TGATGATGATCATTGGCTCCCGGAGGAGTGGTCTGAATCAGAACCTTACACTCAAGAGTCAGTATGAGAGGGCCCTACAAGATCTGGCTGACCTGCTAGA AACTGGTCAGGAGAAGATGGCAGGAGACCAGAAAATCATCGTGTCTTCCAAAGAGGAAATCCAGCAACTACTTGACAAACATAAGGAATACTTTCAGGGC CTGGAATCTCATATGATCTTGACTGAAACACTCTTCAGAAAGATAATCAGCTTTGCAGTCCAAAAGGAAACCCAGTTCCATACAGAGCTGATGGCTCAGG CTTCTGCTGTACTGAAACGGGCTCACAAGAGGGGTGTGGAGCTGGAGTACATTCTAGAGACGTGGTCCCATCTGGATGAGGACCAGCAGGAGCTCAGCAG ACAGCTGGAGGTGGTGGAAAGCAGCATCCCAAGCGTGGGTCTGGTGGAGGAGAACGAGGACAGGCTTATTGACCGCATAACACTCTACCAGCATTTAAAA TCTAGCCTTAATGAATACCAGCCCAAATTATATCAAGTATTAGATGATGGGAAACGACTTCTGATATCCATCAGCTGCTCAGATCTAGAAAGCCAACTAA ATCAACTTGGAGAGTGCTGGCTAAGTAACACCAATAAAATGTCTAAGGAACTTCACAGACTGGAAACAATATTGAAACACTGGACCAGATATCAAAGTGA ATCTGCAGATCTAATTCACTGGTTACAATCTGCAAAAGACCGGCTAGAATTTTGGACTCAGCAATCTGTGACAGTCCCACAAGAGCTGGAAATGGTCCGT GATCATCTAAATGCTTTCCTGGAGTTTTCTAAAGAAGTGGATGCCCAATCTTCCCTGAAATCATCTGTTCTGAGTACTGGAAATCAGCTCCTTCGACTAA AAAAGGTGGACACAGCCACGCTGCGCTCTGAGCTGTCGCGCATTGATAGCCAGTGGACTGACCTGCTAACCAATATCCCAGCCGTCCAGGAGAAGCTCCA CCAGCTCCAGATGGATAAACTGCCTTCCCGCCATGCCATTTCTGAAGTCATGAGTTGGATTTCTCTAATGGAAAATGTTATTCAGAAGGATGAAGATAAT ATTAAAAATTCCATAGGTTACAAGGCAATTCATGAATACCTTCAGAAATATAAGGGTTTTAAGATAGACATTAACTGTAAACAGCTGACAGTGGATTTTG TGAACCAGTCCGTGCTACAAATCAGCAGTCAGGATGTGGAAAGTAAGCGTAGTGATAAGACTGATTTTGCTGAGCAACTTGGAGCAATGAATAAAAGTTG GCAAATTCTGCAAGGTCTAGTAACTGAGAAGATCCAGCTGTTGGAAGGCTTATTGGAATCTTGGTCAGAATATGAAAATAATGTACAATGTCTGAAAACA TGGTTTGAAACCCAGGAAAAGAGACTAAAACAACAGCATCGAATTGGAGATCAGGCTTCTGTTCAAAATGCACTGAAAGACTGTCAGGATCTGGAAGATT TGATTAAAGCAAAAGAAAAAGAAGTAGAGAAAATTGAGCAGAATGGACTTGCTTTGATTCAGAACAAGAAAGAAGACGTCTCTAGCATTGTCATGAGCAC ACTGCGAGAGCTCGGCCAAACCTGGGCAAATTTAGATCACATGGTTGGACAATTAAAGATACTGCTGAAATCAGTGCTTGACCAATGGAGTAGTCACAAA GTGGCCTTTGACAAGATAAACAGTTACCTCATGGAGGCCAGATACTCTCTTTCCCGATTCCGTCTGCTGACTGGCTCCTTAGAAGCTGTGCAAGTTCAGG TGGACAATCTTCAGAATCTCCAAGATGATCTGGAAAAACAGGAAAGGAGCTTACAGAAATTTGGCTCTATCACCAACCAATTATTAAAAGAGTGTCACCC ACCCGTGACAGAAACTCTTACCAATACACTGAAAGAAGTCAACATGAGATGGAATAACTTGCTGGAAGAGATTGCTGAGCAGCTACAGTCCAGCAAGGCC CTACTTCAGCTTTGGCAAAGATACAAGGACTACTCCAAACAGTGTGCTTCGACAGTTCAGCAGCAGGAGGATCGAACCAATGAGCTGTTGAAGGCAGCCA CAAACAAGGACATTGCCGATGATGAGGTTGCCACATGGATTCAAGATTGCAACGACCTCCTCAAAGGACTGGGCACAGTTAAAGATTCCCTCTTTTTTCT CCATGAGCTGGGAGAGCAACTGAAGCAACAAGTGGATGCTTCCGCAGCATCAGCTATTCAATCGGATCAACTCTCTTTGAGTCAACACTTGTGTGCCCTG GAGCAAGCTCTCTGCAAACAGCAGACTTCATTACAGGCTGGAGTTCTTGATTATGAAACCTTTGCCAAGAGTTTAGAAGCTTTGGAGGCCTGGATAGTGG AAGCTGAAGAAATACTACAAGGGCAGGACCCTAGCCACTCATCTGACCTCTCCACAATCCAGGAAAGGATGGAAGAACTTAAGGGACAGATGTTAAAATT CAGCAGCATGGCTCCAGATTTAGACCGTCTAAATGAGCTTGGATATAGGTTACCCTTGAATGATAAGGAAATCAAAAGAATGCAGAATCTGAACCGCCAT TGGTCTCTGATCTCCTCTCAGACTACAGAAAGATTCAGCAAGTTGCAGTCATTTTTGCTACAACATCAGACTTTCTTGGAAAAATGTGAAACATGGATGG AATTCCTAGTTCAGACAGAACAAAAGTTAGCAGTAGAGATTTCAGGAAATTATCAGCACCTTTTGGAACAGCAGAGAGCACACGAGTTGTTTCAAGCCGA GATGTTCAGTCGTCAGCAGATTTTGCACTCAATCATTATTGATGGGCAACGTCTTCTAGAACAAGGTCAAGTTGATGACAGGGATGAATTCAACCTGAAA TTGACACTCCTCAGTAATCAATGGCAGGGAGTGATTCGCAGGGCCCAGCAGAGGCGGGGGATCATTGACAGCCAGATTCGCCAGTGGCAGCGCTATAGGG AGATGGCAGAAAAGCTTCGTAAATGGTTGGTTGAAGTGTCCTACCTCCCCATGAGTGGTCTCGGAAGTGTTCCTATACCACTGCAACAAGCAAGGACCCT CTTTGATGAAGTGCAGTTCAAAGAAAAAGTGTTTCTGCGGCAACAAGGCAGCTACATCCTGACTGTGGAGGCTGGCAAGCAACTCCTTCTCTCGGCGGAC AGTGGCGCTGAGGCCGCCTTGCAGGCCGAACTCGCTGAAATCCAAGAGAAATGGAAATCAGCCAGCATGCGGCTGGAAGAACAGAAGAAAAAACTAGCCT TCTTGTTGAAAGACTGGGAAAAATGTGAGAAAGGAATAGCAGATTCCCTGGAGAAACTACGAACTTTCAAAAAGAAGCTTTCGCAGTCTCTCCCGGATCA CCATGAAGAGCTCCATGCAGAACAAATGCGTTGCAAGGAATTAGAAAATGCAGTTGGGAGCTGGACAGATGACTTGACCCAGTTGAGCCTGCTGAAGGAC ACCCTCTCTGCCTATATCAGTGCTGATGATATCTCCATTCTTAATGAACGCGTAGAGCTTCTGCAAAGGCAGTGGGAAGAACTATGCCACCAGCTCTCCT TAAGGCGGCAGCAAATAGGTGAAAGATTGAATGAATGGGCAGTCTTCAGTGAAAAGAACAAGGAACTCTGTGAGTGGTTGACTCAAATGGAAAGCAAAGT TTCTCAGAATGGAGACATTCTCATTGAAGAAATGATAGAGAAGCTCAAGAAGGATTATCAAGAGGAAATTGCTATTGCTCAAGAGAACAAAATACAGCTC CAACAAATGGGAGAACGACTTGCTAAAGCCAGCCATGAAAGCAAAGCATCTGAGATTGAATACAAGCTGGGAAAGGTCAACGACCGGTGGCAGCATCTCC TGGACCTCATTGCAGCCAGGGTGAAGAAGCTGAAGGAGACCCTGGTAGCCGTGCAGCAGCTTGATAAGAACATGAGCAGCCTGAGGACCTGGCTCGCTCA CATCGAGTCAGAGCTGGCCAAGCCAATAGTCTACGATTCCTGTAACTCGGAAGAAATACAGAGAAAGCTTAATGAGCAGCAGGAGCTTCAGAGAGACATA GAGAAGCACAGTACAGGTGTTGCATCTGTCCTCAACCTGTGTGAAGTCCTGCTGCACGACTGTGACGCCTGTGCCACTGATGCCGAGTGTGACTCTATAC AGCAGGCTACGAGAAACCTGGACCGGCGGTGGAGAAACATTTGTGCTATGTCCATGGAAAGGAGGCTGAAAATCGAAGAGACGTGGCGATTGTGGCAGAA ATTTCTGGATGACTATTCACGTTTTGAAGATTGGCTGAAGTCTTCAGAAAGGACAGCTGCTTTTCCCAGCTCTTCTGGGGTGATCTATACAGTTGCCAAG GAAGAACTAAAGAAATTTGAGGCTTTCCAGCGACAGGTCCACGAGTGCCTGACGCAGCTGGAACTGATCAACAAGCAGTACCGCCGCCTGGCCAGGGAGA ACCGCACTGATTCAGCATGTAGCCTCAAACAGATGGTTCACGAAGGCAACCAGAGATGGGACAACCTGCAAAAGCGTGTCACCTCCATCTTGCGCAGACT CAAGCATTTTATTGGCCAGCGTGAGGAGTTTGAGACTGCGCGGGACAGCATTCTGGTCTGGCTCACAGAGATGGATCTGCAGCTCACTAATATTGAACAT TTTTCTGAGTGTGATGTTCAAGCTAAAATAAAGCAACTCAAGGCCTTCCAGCAGGAAATTTCACTGAACCACAATAAGATTGAGCAGATAATTGCCCAAG GAGAACAGCTGATAGAAAAGAGTGAGCCCTTGGATGCAGCGATCATCGAGGAGGAACTAGATGAGCTCCGACGGTACTGCCAGGAGGTCTTCGGGCGTGT GGAAAGATACCATAAGAAACTGATCCGCCTGCCTCTCCCAGACGATGAGCACGACCTCTCAGACAGGGAGCTGGAGCTGGAAGACTCTGCAGCTCTGTCG GACCTGCACTGGCACGACCGCTCTGCAGACAGCCTGCTTTCTCCACAGCCTTCCTCCAATCTCTCCCTCTCGCTCGCTCAGCCCCTCCGGAGCGAGCGGT CAGGACGAGACACCCCGGCTAGTGTGGACTCCATCCCCCTGGAGTGGGATCACGACTATGACCTCAGTCGGGACCTGGAGTCTGCAATGTCCAGAGCTCT GCCCTCTGAGGATGAAGAAGGTCAGGATGACAAAGATTTCTACCTCCGGGGAGCTGTTGGCTTATCAGGGGACCACAGTGCCCTAGAGTCACAGATCCGA CAACTGGGCAAAGCCCTGGATGATAGCCGTTTTCAGATACAGCAAACCGAAAATATCATTCGCAGCAAAACTCCCACGGGGCCGGAGCTAGACACCAGCT ACAAAGGCTACATGAAACTGCTGGGCGAATGCAGTAGCAGTATAGACTCCGTGAAGAGACTGGAGCACAAACTGAAGGAGGAAGAGGAGAGCCTTCCTGG CTTTGTTAACCTGCATAGTACCGAAACCCAAACGGCTGGTGTGATTGACCGATGGGAGCTTCTCCAGGCCCAGGCATTGAGCAAGGAGTTGAGGATGAAG CAGAACCTCCAGAAGTGGCAGCAGTTTAACTCAGACTTGAACAGCATCTGGGCCTGGCTGGGGGACACGGAGGAGGAGTTGGAACAGCTCCAGCGTCTGG AACTCAGCACTGACATCCAGACCATCGAGCTCCAGATCAAAAAGCTCAAGGAGCTCCAGAAAGCTGTGGACCACCGCAAAGCCATCATCCTCTCCATCAA TCTCTGCAGCCCTGAGTTCACCCAGGCTGACAGCAAGGAGAGCCGGGACCTGCAGGATCGCTTGTCGCAGATGAATGGGCGCTGGGACCGAGTGTGCTCT CTGCTGGAGGAGTGGCGGGGCCTGCTGCAGGATGCCCTGATGCAGTGCCAGGGTTTCCATGAAATGAGCCATGGTTTGCTTCTTATGCTGGAGAACATTG ACAGAAGGAAAAATGAAATTGTCCCTATTGATTCTAACCTTGATGCAGAGATACTTCAGGACCATCACAAACAGCTTATGCAAATAAAGCATGAGCTGTT GGAATCCCAACTCAGAGTAGCCTCTTTGCAAGACATGTCTTGCCAACTACTGGTGAATGCTGAAGGAACAGACTGTTTAGAAGCCAAAGAAAAAGTCCAT GTTATTGGAAATCGGCTCAAACTTCTCTTGAAGGAGGTCAGTCGTCATATCAAGGAACTGGAGAAGTTATTAGACGTGTCAAGTAGTCAGCAGGATTTGT CTTCCTGGTCTTCTGCTGATGAACTGGACACCTCAGGGTCTGTGAGTCCCACATCAGGAAGGAGCACCCCAAACAGACAGAAAACGCCACGAGGCAAGTG TAGTCTCTCACAGCCTGGACCCTCTGTCAGCAGTCCACATAGCAGGTCCACAAAAGGTGGCTCCGATTCCTCCCTTTCTGAGCCAGGGCCAGGTCGGTCC GGCCGCGGCTTCCTGTTCAGAGTCCTCCGAGCAGCTCTTCCCCTTCAGCTTCTCCTGCTCCTCCTCATCGGGCTTGCCTGCCTTGTACCAATGTCAGAGG AAGACTACAGCTGTGCCCTCTCCAACAACTTTGCCCGGTCATTCCACCCCATGCTCAGATACACGAATGGCCCTCCTCCACTCTGAACTAAGCAGATGCC ATCTGCAGAAGTGCTGGTAGCATAAGGAGGATCGGGTCATAAGCAATCCCAAACTACCAACAAGAGGACCTTGATCTTGGCGAAAGCCCTCGGTGTGGCA GCTTTAGCCCTCCTCCAGATCACATGTGTGCAAATTATGGCTTCAGAGGTGGAAGATAAACAGTGACGGGGGAACAAACAGACAACAAGAAGGTTTGGAA GAAATCTGGTTTGAGACTCTGAACCTTAGCACTAAGGAGATTGAGTAAGGACCTCCAAAGTTCCCCGGACTCATGAATTCTGGGCCCTTGGCCCATTCTG TGCACAGCCAAGGACTTCAGTAGACCATCTGGGCAGCTTTCCCATGGTGCTGCTCCAACCATCAGATAAATGACCCTCCCAAGCACCATGTCAGTGTCGT ACAATCTACCAACCAACCAGTGCTGAAGAGATTTTAGAACCTTGTAACATACAATTTTTAAGAGCTTATATGGCAGCTTCCTTTTTACCTTGTTTTCCTT TGGGGCATGATGTTTTAACCTTTGCTTTAGAAGCACAAGCTGTAAATCTAAAAGGCACTTTTTTTTAGAGGTATAAAGAAAAACTAGATGTAATAAATAA GATCATGGAAGGCTTTATGTGAAAAAAGTTGAATGTTATAGTAAAAAAAAAAAGATATTTATGTATGTACAGTTTGCTAAAGCCAAGTTTTGTTTGTATT GATTTCTTTGCATTTATTATAGATATTATAAAAT

refseq_SYNE1.F5 (forward primer)
refseq_SYNE1.R5 (reverse primer)
Single exon skipping

Frame 0

QKSV*SRETWRNLFSVL*CSFILVTIKVLGEEL DGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGK LTELHQQTIRQAENRLSKLNQAASHLEEYNEML ELILKWIEKAKVLAHGTIAWNSASQLREQYILH QTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMS QQVAELGRETEELRQMIKIRLQNLQDAAKDMKK FEAELKKLQAALEQAQATLTSPEVGRLSLKEQL SHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVV ASLPLCHAALRLQEEASRLQHTAIQQCNIMQAA VVQYEQYEQEMKHLQQLIEGAHREIEDKPVATS NIQELQAQISRHEELAQKIKGYQEQIASLNSKCK MLTMKAKHATMLLTVTEVEGLAEGTEDLDGELL PTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGT NSEISSPPACRSPSPVANTDASVNQDIAYYQALS AERLQTDAAKIHPSTSASQEFYEPGLEPSATAK LGDLQRSWETLKNVISEKQRTLYEALERQQKYQ DSLQSISTKMEAIELKLSESPEPGRSPESQMAEH QALMDEILMLQDEINELQSSLAEELVSESCEAD PAEQLALQSTLTVLAERMSTIRMKASGKRQLLE EKLNDQLEEQRQEQALQRYRCEADELDSWLLSTK ATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQK VVALSELSVHNENLLLEGKAHTKDEAEQLAGKL RRLKGSLLELQRALHDKQLNMQGTAQEKEESDVD LTATQSPGVQEWLAQARTTWTQQRQSSLQQQKE LEQELAEQKSLLRSVASRGEEILIQHSAAETSG DAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLH QEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGV PLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQS GGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFV ATALLPEETETCLFNQEILAKDIKEMSEEMDKN KNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLD SVVNQRCHQMKERLQQILNFQNDLKVLFTSLADN KYIILQKLANVFEQPVAEQIEAIQQAEDGLKEF DAGIIELKRRGDKLQVEQPSMQELSKLQDMYDE LMMIIGSRRSGLNQNLTLKSQYERALQDLADLLE TGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQG LESHMILTETLFRKIISFAVQKETQFHTELMAQ ASAVLKRAHKRGVELEYILETWSHLDEDQQELSR QLEVVESSIPSVGLVEENEDRLIDRITLYQHLK SSLNEYQPKLYQVLDDGKRLLISISCSDLESQL NQLGECWLSNTNKMSKELHRLETILKHWTRYQSE SADLIHWLQSAKDRLEFWTQQSVTVPQELEMVR DHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRL KKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLH QLQMDKLPSRHAISEVMSWISLMENVIQKDEDN IKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDF VNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSW QILQGLVTEKIQLLEGLLESWSEYENNVQCLKT WFETQEKRLKQQHRIGDQASVQNALKDCQDLED LIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMST LRELGQTWANLDHMVGQLKILLKSVLDQWSSHK VAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQ VDNLQNLQDDLEKQERSLQKFGSITNQLLKECHP PVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKA LLQLWQRYKDYSKQCASTVQQQEDRTNELLKAA TNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFL HELGEQLKQQVDASAASAIQSDQLSLSQHLCAL EQALCKQQTSLQAGVLDYETFAKSLEALEAWIV EAEEILQGQDPSHSSDLSTIQERMEELKGQMLKF SSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRH WSLISSQTTERFSKLQSFLLQHQTFLEKCETWM EFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAE MFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLK LTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYR EMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTL FDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD SGAEAALQAELAEIQEKWKSASMRLEEQKKKLA FLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDH HEELHAEQMRCKELENAVGSWTDDLTQLSLLKD TLSAYISADDISILNERVELLQRQWEELCHQLS LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKV SQNGDILIEEMIEKLKKDYQEEIAIAQENKIQL QQMGERLAKASHESKASEIEYKLGKVNDRWQHL LDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAH IESELAKPIVYDSCNSEEIQRKLNEQQELQRDI EKHSTGVASVLNLCEVLLHDCDACATDAECDSI QQATRNLDRRWRNICAMSMERRLKIEETWRLWQK FLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAK EELKKFEAFQRQVHECLTQLELINKQYRRLARE NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRL KHFIGQREEFETARDSILVWLTEMDLQLTNIEH FSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQ GEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRV ERYHKKLIRLPLPDDEHDLSDRELELEDSAALS DLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER SGRDTPASVDSIPLEWDHDYDLSRDLESAMSRAL PSEDEEGQDDKDFYLRGAVGLSGDHSALESQIR QLGKALDDSRFQIQQTENIIRSKTPTGPELDTS YKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPG FVNLHSTETQTAGVIDRWELLQAQALSKELRMK QNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRL ELSTDIQTIELQIKKLKELQKAVDHRKAIILSIN LCSPEFTQADSKESRDLQDRLSQMNGRWDRVCS LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENI DRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELL ESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVH VIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDL SSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKC SLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRS GRGFLFRVLRAALPLQLLLLLLIGLACLVPMSE EDYSCALSNNFARSFHPMLRYTNGPPPL*TKQMP SAEVLVA*GGSGHKQSQTTNKRTLILAKALGVA ALALLQITCVQIMASEVEDKQ*RGNKQTTRRFG RNLV*DSEP*H*GD*VRTSKVPRTHEFWALGPFC AQPRTSVDHLGSFPMVLLQPSDK*PSQAPCQCR TIYQPTSAEEILEPCNIQFLRAYMAASFLPCFP LGHDVLTFALEAQAVNLKGTFF*RYKEKLDVINK IMEGFM*KKLNVIVKKKRYLCMYSLLKPSFVCI DFFAFIIDIIK

Frame 1

KNQSDLGKPGEIYFLYSNVLSFW*PSRCWERN* MAVIQS*WN*MQQYRNSWNRMANWVSHWPRR*E N*LNFTSRPLDKLRIGSPSSIRQHHI*KNTMKCL N*F*SGLKKLKSWLMELLHGILQASFGNNIFCI RPC*KNPKKLTVSWKQ*LRNYSTSLACTVQKKC LSKWQNWDGRLRSCDR*SKFVCRTSKMQLRI*KN LKQS*KSYKLPWSKPRQH*LLQKLDVSVSRSSS LIGSICCLRWSH*SRRCKQCSSARVPSGSPRMW LPAYLSVMLLCGCRKRPAGCSTPPSSSVTSCRQL WYNMNNMSKK*NISSN**KELTERLRINLLPPV TYRSCRLRFLGMRSWRRKLRATRSRSLL*IPSA RC*R*KPSTPPCC*R*PRSRGWRKGQRTWMGSSS PRLRPTPLWS**LQVAVTLCCHRSLRSLGRREP TVRFPLHLPVAPLHLWLIQMLLLTRTLHITKPC LLRGCRQMLQKFTPAHPHPRSSMNRDWSHPLLPN WVICSVLGKP*RM*SVRSSAHSMKLWNASRSTR TPSSPSLRRWRPLS*NSVRAQSLAGVQKARWLN IRH*WMRFSCSRMKSMSSSPLSQRSWYPSLVRPT LRSSWPCSPRSLS*PSECPPSG*KPRGNGSFWR RS*MISWRNKGRNRPCRGIAVKPMSWTAGS*VP RPLWTLR*VHPRSPWTWRPSLWTARICWWK*SRR WWLYQNCQSTMRTCCWRAKLTPRTRPSSWLES* EGSRGACWSCREPCMISSSTCREQHRRRRRAML T*QPRRAPASRNGWPKLAPHGPSSGRAVSSNKKS *NRN*PSRRVSFAQ*PVVERRF*FNIRRQRPLV MLAKNLMCYPRSWGWKGRNHPLKTR*E*NGKAY IKNLVPSRNYYRMFWNRNKSKCFIAGQIDSCLVC HCTKGTCQPKINLQLHLCWMD*TKPSRRFHPRV EGQRGRVYTWSRSCMMESQPPLLGWMTLKNVYL LPQHFYQKKQRLVSSTKRFLPKTLRKCLKKWIRT KTCFPKLFQRMVIIEMLLKILWVVFWAGYPC*T Q**INDVIR*KKDFSKY*ISRMI*KCCLHHWLT TNTSFCKNWQMCLNSP*QNK*RQYNRLKMDSKNL MQESLN*RGVVTSYRSSSRPCKNSPSSRTCMMS ***SLAPGGVV*IRTLHSRVSMRGPYKIWLTC* KLVRRRWQETRKSSCLPKRKSSNYLTNIRNTFRA WNLI*S*LKHSSER*SALQSKRKPSSIQS*WLR LLLY*NGLTRGVWSWSTF*RRGPIWMRTSRSSA DSWRWWKAASQAWVWWRRTRTGLLTA*HSTSI*N LALMNTSPNYIKY*MMGNDF*YPSAAQI*KAN* INLESAG*VTPIKCLRNFTDWKQY*NTGPDIKV NLQI*FTGYNLQKTG*NFGLSNL*QSHKSWKWSV II*MLSWSFLKKWMPNLP*NHLF*VLEISSFD* KRWTQPRCALSCRALIASGLTC*PISQPSRRSS TSSRWINCLPAMPFLKS*VGFL*WKMLFRRMKII LKIP*VTRQFMNTFRNIRVLR*TLTVNS*QWIL *TSPCYKSAVRMWKVSVVIRLILLSNLEQ*IKV GKFCKV**LRRSSCWKAYWNLGQNMKIMYNV*KH GLKPRKRD*NNSIELEIRLLFKMH*KTVRIWKI *LKQKKKK*RKLSRMDLL*FRTRKKTSLALS*A HCESSAKPGQI*ITWLDN*RYC*NQCLTNGVVTK WPLTR*TVTSWRPDTLFPDSVC*LAP*KLCKFR WTIFRISKMIWKNRKGAYRNLALSPTNY*KSVT HP*QKLLPIH*KKST*DGITCWKRLLSSYSPARP YFSFGKDTRTTPNSVLRQFSSRRIEPMSC*RQP QTRTLPMMRLPHGFKIATTSSKDWAQLKIPSFF SMSWESN*SNKWMLPQHQLFNRINSL*VNTCVPW SKLSANSRLHYRLEFLIMKPLPRV*KLWRPG*W KLKKYYKGRTLATHLTSPQSRKGWKNLRDRC*N SAAWLQI*TV*MSLDIGYP*MIRKSKECRI*TAI GL*SPLRLQKDSASCSHFCYNIRLSWKNVKHGW NS*FRQNKS*Q*RFQEIISTFWNSREHTSCFKP RCSVVSRFCTQSLLMGNVF*NKVKLMTGMNST*N *HSSVINGRE*FAGPSRGGGSLTARFASGSAIG RWQKSFVNGWLKCPTSP*VVSEVFLYHCNKQGP SLMKCSSKKKCFCGNKAATS*LWRLASNSFSRRT VALRPPCRPNSLKSKRNGNQPACGWKNRRKN*P SC*KTGKNVRKE*QIPWRNYELSKRSFRSLSRI TMKSSMQNKCVARN*KMQLGAGQMT*PS*AC*RT PSLPISVLMISPFLMNA*SFCKGSGKNYATSSP *GGSK*VKD*MNGQSSVKRTRNSVSG*LKWKAK FLRMETFSLKK**RSSRRIIKRKLLLLKRTKYSS NKWENDLLKPAMKAKHLRLNTSWERSTTGGSIS WTSLQPG*RS*RRPW*PCSSLIRT*AA*GPGSL TSSQSWPSQ*STIPVTRKKYRESLMSSRSFRET* RSTVQVLHLSSTCVKSCCTTVTPVPLMPSVTLY SRLRETWTGGGETFVLCPWKGG*KSKRRGDCGR NFWMTIHVLKIG*SLQKGQLLFPALLG*SIQLPR KN*RNLRLSSDRSTSA*RSWN*STSSTAAWPGR TALIQHVASNRWFTKATRDGTTCKSVSPPSCAD SSILLASVRSLRLRGTAFWSGSQRWICSSLILNI FLSVMFKLK*SNSRPSSRKFH*TTIRLSR*LPK ENS**KRVSPWMQRSSRRN*MSSDGTARRSSGV WKDTIRN*SACLSQTMSTTSQTGSWSWKTLQLCR TCTGTTALQTACFLHSLPPISPSRSLSPSGASG QDETPRLVWTPSPWSGITTMTSVGTWSLQCPEL CPLRMKKVRMTKISTSGELLAYQGTTVP*SHRSD NWAKPWMIAVFRYSKPKISFAAKLPRGRS*TPA TKAT*NCWANAVAV*TP*RDWSTN*RRKRRAFL ALLTCIVPKPKRLV*LTDGSFSRPRH*ARS*G*S RTSRSGSSLTQT*TASGPGWGTRRRSWNSSSVW NSALTSRPSSSRSKSSRSSRKLWTTAKPSSSPS ISAALSSPRLTARRAGTCRIACRR*MGAGTECAL CWRSGGACCRMP*CSARVSMK*AMVCFLCWRTL TEGKMKLSLLILTLMQRYFRTITNSLCK*SMSC WNPNSE*PLCKTCLANYW*MLKEQTV*KPKKKSM LLEIGSNFS*RRSVVISRNWRSY*TCQVVSRIC LPGLLLMNWTPQGL*VPHQEGAPQTDRKRHEAS VVSHSLDPLSAVHIAGPQKVAPIPPFLSQGQVGP AAASCSESSEQLFPFSFSCSSSSGLPALYQCQR KTTAVPSPTTLPGHSTPCSDTRMALLHSELSRC HLQKCW*HKEDRVISNPKLPTRGP*SWRKPSVWQ L*PSSRSHVCKLWLQRWKINSDGGTNRQQEGLE EIWFETLNLSTKEIE*GPPKFPGLMNSGPLAHS VHSQGLQ*TIWAAFPWCCSNHQINDPPKHHVSVV QSTNQPVLKRF*NLVTYNF*ELIWQLPFYLVFL WGMMF*PLL*KHKL*I*KALFFRGIKKN*M**I RSWKALCEKS*ML**KKKDIYVCTVC*SQVLFVL ISLHLL*IL*N

Frame 2

KISLISGNLEKFIFCTLMFFHFGDHQGAGRGIR WL*FKVNGIRCSSTEILGTEWPTG*ATGQEDRK TD*TSPADH*TS*ESALQAQSGSITFRRIQ*NA *INFEVD*KS*SLGSWNYCMEFCKPASGTIYFAS DPARRIQRN*Q*AGSND*EITVPH*RVLYRKNV SASGRTGTGD*GVATDDQNSFAEPPRCS*GYEK I*SRVEKVTSCLGASPGNTDFSRSWTSQSQGAAL SSAAFVV*DGVTEAEGASSAALPECPPDPRGCG CQLTSLSCCSAAAGRGQPAAAHRHPAV*HHAGS CGTI*TI*ARNETSPATDRRSSQRD*G*TCCHQ* HTGAAGSDFSA*GAGAEN*GLPGADRFFEFQVQ DADDESQARHHAADGDRGRGAGGRDRGPGWGAP PHAFGPPLCGHDDCRSLSHFAVTGH*GVWGGGNQ Q*DFLSTCLSLPFTCG*YRCFC*PGHCILPSLV C*EVADRCCKNSPQHIRIPGVL*TGIGAIRYCQ TG*FAAFLGNLKECDQ*EAAHTL*SFGTPAEVPG LPPVHLYEDGGH*AETQ*EPRAWQESRKPDG*T SGIDG*DSHAPG*NQ*APVLSRRGAGIRVL*GR PCGAAGLAVHAHCLSRANVHHQDESLGETAAFGG EVE*SAGGTKAGTGPAEVSL*SR*AGQLALEYQ GHSGHCAESTQGAHGHGGPAYGLPEYAGGNRAE GGGFIRTVSPQ*EPAAGGQSSHQGRGRAAGWKAE KAQGEPAGAAESPA**AAQHAGNSTGEGGERC* PNSHAEPRRPGMAGPSSHHMDPAAAEQSPATKR VRTGISRAEESPSLSSQSWRGDSNSTFGGRDLW* CWRKT*CVIPGVGDGRGEIIR*RPDENEMGKPT SRI*YQAETTTECSGTGTRASAL*QAKSTLVWC ATVQRGRANPR*ICSYIFAGWTEPSLRGGFIPEW RGKEAEYTLGAEVV*WSLSHLYLVG*R*RTFIC CHSTFTRRNRDLSLQPRDSCQRH*GNV*RNG*E QKLVFPSFSREW**SRCY*RYFGLSFGQVILARL SSESTMSSDERKTSANTKFPE*SESAVYITG*Q QIHHSAKTGKCV*TARSRTNRGNTTG*RWTQRI *CRNH*IKEAW*QATGRAAVHARTLQAPGHV**A DDDHWLPEEWSESEPYTQESV*EGPTRSG*PAR NWSGEDGRRPENHRVFQRGNPATT*QT*GILSG PGISYDLD*NTLQKDNQLCSPKGNPVPYRADGSG FCCTETGSQEGCGAGVHSRDVVPSG*GPAGAQQ TAGGGGKQHPKRGSGGGERGQAY*PHNTLPAFK I*P**IPAQIISSIR*WETTSDIHQLLRSRKPTK STWRVLAK*HQ*NV*GTSQTGNNIETLDQISK* ICRSNSLVTICKRPARILDSAICDSPTRAGNGP *SSKCFPGVF*RSGCPIFPEIICSEYWKSAPSTK KGGHSHAAL*AVAH**PVD*PANQYPSRPGEAP PAPDG*TAFPPCHF*SHELDFSNGKCYSEG*R* Y*KFHRLQGNS*IPSEI*GF*DRH*L*TADSGFC EPVRATNQQSGCGK*A***D*FC*ATWSNE*KL ANSARSSN*EDPAVGRLIGILVRI*K*CTMSEN MV*NPGKETKTTASNWRSGFCSKCTERLSGSGRF D*SKRKRSREN*AEWTCFDSEQERRRL*HCHEH TARARPNLGKFRSHGWTIKDTAEISA*PME*SQ SGL*QDKQLPHGGQILSFPIPSADWLLRSCASSG GQSSESPR*SGKTGKELTEIWLYHQPIIKRVSP TRDRNSYQYTERSQHEME*LAGRDC*AATVQQG PTSALAKIQGLLQTVCFDSSAAGGSNQ*AVEGSH KQGHCR**GCHMDSRLQRPPQRTGHS*RFPLFS P*AGRATEATSGCFRSISYSIGSTLFESTLVCP GASSLQTADFITGWSS*L*NLCQEFRSFGGLDSG S*RNTTRAGP*PLI*PLHNPGKDGRT*GTDVKI QQHGSRFRPSK*AWI*VTLE**GNQKNAESEPP LVSDLLSDYRKIQQVAVIFATTSDFLGKM*NMDG IPSSDRTKVSSRDFRKLSAPFGTAESTRVVSSR DVQSSADFALNHY*WATSSRTRSS**QG*IQPE IDTPQ*SMAGSDSQGPAEAGDH*QPDSPVAAL*G DGRKAS*MVG*SVLPPHEWSRKCSYTTATSKDP L**SAVQRKSVSAATRQLHPDCGGWQATPSLGG QWR*GRLAGRTR*NPREMEISQHAAGRTEEKTSL LVERLGKM*ERNSRFPGETTNFQKEAFAVSPGS P*RAPCRTNALQGIRKCSWELDR*LDPVEPAEG HPLCLYQC**YLHS**TRRASAKAVGRTMPPALL KAAANR*KIE*MGSLQ*KEQGTL*VVDSNGKQS FSEWRHSH*RNDREAQEGLSRGNCYCSREQNTA PTNGRTTC*SQP*KQSI*D*IQAGKGQRPVAASP GPHCSQGEEAEGDPGSRAAA**EHEQPEDLARS HRVRAGQANSLRFL*LGRNTEKA**AAGASERH REAQYRCCICPQPV*SPAARL*RLCH*CRV*LYT AGYEKPGPAVEKHLCYVHGKEAENRRDVAIVAE ISG*LFTF*RLAEVFRKDSCFSQLFWGDLYSCQ GRTKEI*GFPATGPRVPDAAGTDQQAVPPPGQGE PH*FSM*PQTDGSRRQPEMGQPAKACHLHLAQT QAFYWPA*GV*DCAGQHSGLAHRDGSAAH*Y*T FF*V*CSS*NKATQGLPAGNFTEPQ*D*ADNCPR RTADRKE*ALGCSDHRGGTR*APTVLPGGLRAC GKIP*ETDPPASPRR*ARPLRQGAGAGRLCSSV GPALARPLCRQPAFSTAFLQSLPLARSAPPERAV RTRHPG*CGLHPPGVGSRL*PQSGPGVCNVQSS AL*G*RRSG*QRFLPPGSCWLIRGPQCPRVTDP TTGQSPG**PFSDTANRKYHSQQNSHGAGARHQL QRLHETAGRMQ*QYRLREETGAQTEGGRGEPSW LC*PA*YRNPNGWCD*PMGASPGPGIEQGVEDE AEPPEVAAV*LRLEQHLGLAGGHGGGVGTAPASG TQH*HPDHRAPDQKAQGAPESCGPPQSHHPLHQ SLQP*VHPG*QQGEPGPAGSLVADEWALGPSVL SAGGVAGPAAGCPDAVPGFP*NEPWFASYAGEH* QKEK*NCPY*F*P*CRDTSGPSQTAYANKA*AV GIPTQSSLFARHVLPTTGEC*RNRLFRSQRKSP CYWKSAQTSLEGGQSSYQGTGEVIRRVK*SAGFV FLVFC**TGHLRVCESHIRKEHPKQTENATRQV *SLTAWTLCQQST*QVHKRWLRFLPF*ARARSV RPRLPVQSPPSSSSPSASPAPPHRACLPCTNVRG RLQLCPLQQLCPVIPPHAQIHEWPSSTLN*ADA ICRSAGSIRRIGS*AIPNYQQEDLDLGESPRCG SFSPPPDHMCANYGFRGGR*TVTGEQTDNKKVWK KSGLRL*TLALRRLSKDLQSSPDS*ILGPWPIL CTAKDFSRPSGQLSHGAAPTIR*MTLPSTMSVS YNLPTNQC*RDFRTL*HTIFKSLYGSFLFTLFSF GA*CFNLCFRSTSCKSKRHFFLEV*RKTRCNK* DHGRLYVKKVECYSKKKKIFMYVQFAKAKFCLY *FLCIYYRYYK

Sequence NM_033071

CGGCCGCCGGCCGCAGCGGGCTGAGATTGTTGTCCTCTGTCACCAGGGCGGCTGGGCTCCCGCAGTCCTGCAGACCGCGCCCGATCCCGGCGACAGGGCG GGCGGACAGCCGCGCATCCCCGGGGTCCCGCCGAGCCTGGGCGCAGAGAGCCGGGAGGAAGCGTTCGCTCGCTTCGCCTTGCTGCTGGGAAACTGAACGA GGCCGAGAGAGAAGGTTCTTGAGTTCATGTAAGAGGACAGTCTTAAAACGGAAGAAGAAAAAGAAGCAGTTCAGTCTTTGGGAGAGCTGCCTCCTTGTTG AGTGCTGCAAAGGCCTGGAATTCATTTATGACAGAATAGATCTAGAAAAGTCCAAGCATGTTTTCTAGAGTGGTGTAGCCCTGTGCTGCCTCCAGTGAAG AGTCTCTTGGTGTTGGCTTCGTGCTTCCGGAGGGACCATGGCAACCTCCAGAGGGGCCTCCCGGTGTCCTCGGGATATCGCCAATGTGATGCAGAGGCTG CAAGATGAGCAAGAGATAGTACAAAAACGAACTTTCACAAAATGGATCAACTCTCATCTGGCCAAGCGGAAACCTCCAATGGTGGTGGACGATCTTTTTG AAGACATGAAAGATGGTGTTAAACTGCTTGCCCTTCTGGAGGTCCTGTCTGGGCAGAAACTGCCTTGTGAACAAGGACGCCGGATGAAGCGAATCCATGC TGTGGCTAACATTGGCACGGCACTCAAGTTCCTCGAAGGAAGAAAGTCCATGCACAGAGGATCACCGATTAAATTAGTCAACATTAACTCCACCGATATA GCTGATGGCCGACCCTCAATAGTTCTTGGATTGATGTGGACCATTATTCTATATTTCCAGATTGAAGAGTTGACCAGCAACCTGCCCCAGCTCCAGTCTT TGTCCAGCAGCGCATCCTCCGTGGACAGCATAGTTAGCTCTGAGACTCCCAGCCCACCAAGTAAACGGAAGGTGACCACCAAGATCCAAGGAAATGCTAA GAAGGCTTTATTAAAGTGGGTTCAGTACACAGCTGGCAAGCAGACTGGAATAGAAGTAAAAGATTTTGGGAAGAGTTGGAGAAGCGGGGTTGCCTTTCAT TCAGTTATTCATGCCATTCGACCGGAATTGGTGGACTTGGAGACAGTGAAAGGCAGATCCAACCGAGAAAATTTGGAGGATGCTTTCACTATCGCCGAAA CAGAACTGGGGATCCCAAGACTGCTAGATCCTGAAGACGTTGATGTGGATAAACCAGATGAGAAATCTATTATGACCTATGTAGCCCAGTTTCTGAAACA TTATCCTGACATCCACAATGCAAGCACTGATGGGCAAGAGGATGATGAAATACTTCCAGGTTTCCCATCTTTTGCAAATTCTGTACAAAATTTTAAGAGA GAAGACAGAGTAATTTTTAAGGAAATGAAAGTTTGGATAGAACAATTTGAGAGAGATTTGACAAGAGCACAGATGGTGGAATCAAATTTACAGGATAAAT ATCAGTCATTTAAGCACTTCAGAGTTCAATATGAAATGAAGAGGAAACAGATTGAACATTTAATACAACCATTACACAGAGACGGTAAATTGTCACTTGA CCAAGCATTGGTAAAACAATCTTGGGATAGAGTGACCTCCAGGCTCTTTGACTGGCATATACAGCTTGATAAATCTCTTCCTGCACCTCTGGGCACCATA GGTGCCTGGCTGTACAGAGCGGAGGTGGCCCTGAGAGAGGAAATAACCGTTCAACAGGTCCACGAGGAAACAGCAAACACGATACAACGGAAACTTGAGC AACATAAGGATCTGCTTCAAAACACGGATGCCCACAAAAGAGCATTCCATGAAATCTACCGGACCAGGTCTGTTAACGGGATTCCAGTGCCACCTGATCA ATTAGAGGACATGGCCGAGAGGTTTCATTTTGTTTCCTCCACATCAGAGCTACACCTAATGAAAATGGAATTTTTAGAATTAAAGTACCGTCTGCTCTCA CTGCTGGTTCTTGCAGAGTCAAAGCTGAAGTCTTGGATCATTAAGTACGGGAGGAGAGAGTCAGTGGAGCAGCTTCTACAAAACTACGTGTCTTTTATAG AAAATAGCAAGTTCTTTGAACAATATGAGGTGACATACCAGATCTTGAAACAGACAGCTGAGATGTATGTCAAAGCAGATGGTTCAGTGGAAGAAGCTGA GAATGTGATGAAATTCATGAATGAAACCACCGCTCAGTGGAGGAATCTCTCAGTAGAAGTGAGGAGTGTGAGGAGCATGCTGGAAGAAGTGATCTCTAAC TGGGATCGCTATGGCAATACAGTGGCTAGTCTGCAAGCCTGGCTAGAGGATGCTGAAAAAATGCTCAATCAATCAGAAAATGCCAAAAAGGATTTTTTTC GAAATTTACCTCATTGGATTCAGCAGCATACTGCCATGAACGATGCTGGCAATTTTCTAATTGAAACCTGTGATGAGATGGTTTCCCGTGACCTGAAGCA GCAATTACTGTTGCTAAATGGGCGGTGGAGGGAGTTGTTTATGGAAGTCAAGCAATATGCTCAAGCTGATGAGATGGACAGAATGAAGAAGGAATACACA GACTGTGTTGTTACCCTGTCTGCTTTTGCAACGGAAGCCCATAAGAAACTTTCTGAACCCTTAGAAGTCTCTTTTATGAATGTCAAGCTATTAATTCAAG ACTTGGAGGATATTGAGCAGAGGGTGCCTGTGATGGATGCCCAATACAAGATAATTACAAAGACAGCACACCTCATTACCAAAGAAAGCCCCCAAGAAGA AGGAAAAGAAATGTTTGCGACCATGTCAAAGCTCAAAGAGCAGCTAACCAAGGTCAAAGAATGTTACTCCCCACTCCTTTATGAGTCTCAGCAGCTGTTG ATTCCGTTGGAGGAATTAGAAAAGCAGATGACGTCCTTTTATGACTCACTTGGGAAAATCAATGAAATTATCACAGTTCTTGAGCGTGAGGCACAATCGA GTGCCCTTTTTAAACAAAAACATCAGGAACTGTTAGCTTGTCAAGAAAACTGTAAGAAAACCTTGACACTTATTGAGAAAGGCAGTCAAAGTGTTCAAAA GTTTGTGACCTTGAGCAACGTGTTAAAGCATTTTGATCAGACGAGGCTACAAAGACAGATTGCAGATATTCATGTTGCTTTTCAGAGTATGGTAAAGAAA ACTGGAGATTGGAAGAAGCATGTGGAAACCAACAGTCGCTTGATGAAGAAGTTTGAGGAGTCTCGAGCAGAGTTGGAGAAGGTACTGCGGATTGCTCAGG AGGGCCTGGAGGAAAAGGGGGATCCAGAGGAGCTCCTGCGGAGACACACTGAGTTTTTCAGTCAGCTGGATCAGAGGGTGCTCAATGCTTTCCTGAAAGC TTGTGATGAACTCACCGACATCCTTCCAGAGCAGGAGCAGCAGGGGCTGCAGGAAGCTGTTCGAAAGCTCCACAAACAATGGAAGGATCTTCAAGGAGAA GCCCCTTATCATTTGCTTCATCTGAAGATTGATGTGGAGAAGAATAGGTTCTTAGCCTCTGTAGAAGAATGCAGAACTGAGCTGGATCGAGAGACCAAGC TGATGCCCCAGGAAGGCAGTGAAAAGATAATTAAAGAGCACAGGGTTTTCTTCAGTGACAAAGGTCCTCATCATCTCTGTGAGAAAAGGTTACAGCTCAT CGAGGAACTCTGTGTGAAACTCCCAGTGCGGGACCCAGTAAGGGACACACCTGGAACCTGTCACGTGACTCTCAAAGAGCTCAGAGCTGCCATTGACAGC ACCTACAGGAAGCTCATGGAAGACCCAGACAAGTGGAAGGACTACACTAGCAGATTCTCTGAGTTCTCATCTTGGATATCTACAAATGAGACACAATTAA AGGGGATCAAGGGTGAGGCCATCGATACTGCCAACCACGGAGAGGTTAAACGTGCCGTTGAAGAGATCAGAAATGGTGTTACCAAAAGGGGTGAGACCCT CAGCTGGCTGAAATCCAGGCTGAAAGTTTTGACAGAAGTTTCTTCTGAGAATGAAGCCCAAAAGCAGGGAGATGAGCTGGCAAAATTATCCAGCTCTTTC AAGGCTCTTGTGACGCTGCTGTCAGAGGTTGAAAAGATGCTAAGCAATTTTGGGGACTGTGTCCAGTACAAAGAAATAGTCAAAAATTCTCTCGAAGAAT TAATTTCTGGCTCTAAAGAAGTCCAGGAACAAGCTGAGAAGATCTTGGATACTGAAAATCTGTTTGAAGCACAGCAGTTACTTCTTCATCACCAGCAAAA GACAAAGCGGATCTCAGCAAAGAAGAGAGATGTGCAGCAGCAGATCGCGCAGGCGCAGCAGGGAGAAGGGGGGCTGCCTGACCGAGGCCACGAGGAGCTG CGGAAGCTGGAGAGCACACTGGATGGCCTGGAGCGCAGCCGGGAGAGGCAGGAACGCCGCATCCAGGTCACATTAAGAAAATGGGAGCGATTTGAAACAA ACAAAGAAACAGTAGTAAGATACCTTTTTCAAACAGGTTCCAGTCATGAACGCTTCTTGAGTTTTAGCAGTTTGGAAAGTTTATCTTCAGAACTGGAACA AACAAAGGAGTTTTCTAAACGGACAGAAAGTATTGCAGTCCAGGCTGAGAACCTTGTAAAGGAAGCTTCAGAGATACCGCTTGGGCCCCAAAATAAGCAG CTGCTTCAACAGCAGGCCAAGTCAATCAAAGAACAAGTCAAAAAATTAGAAGACACGCTTGAAGAAGATATTAAAACCATGGAAATGGTGAAAACCAAGT GGGATCATTTTGGCAGTAATTTTGAGACTCTGTCCGTCTGGATAACTGAGAAAGAAAAAGAACTCAATGCCTTGGAAACTTCGTCATCTGCCATGGACAT GCAAATCAGCCAAATTAAGGTCACAATTCAGGAAATAGAAAGTAAGCTCAGCAGCATTGTAGGATTAGAAGAAGAAGCCCAGTCTTTTGCTCAGTTTGTT ACCACTGGAGAATCTGCTCGAATTAAAGCCAAGTTGACACAAATAAGAAGATACGGGGAAGAGCTTCGAGAGCATGCACAGTGTCTGGAAGGAACAATCC TGGGACATTTATCTCAGCAGCAAAAGTTTGAAGAGAACCTTAGAAAGATCCAGCAATCTGTGTCTGAATTTGAAGATAAACTTGCTGTTCCAATTAAAAT ATGTTCTTCAGCTACAGAAACATACAAAGTTCTTCAAGAACATATGGATCTCTGCCAGGCCCTGGAGTCACTGAGCAGCGCGATCACTGCCTTCTCAGCC AGTGCCAGGAAGGTTGTGAACAGAGATTCCTGTGTTCAGGAGGCTGCGGCTCTACAGCAGCAATACGAGGACATCCTAAGGAGGGCGAAGGAGAGACAGA CGGCGCTGGAGAATCTGCTGGCCCACTGGCAGAGGCTAGAGAAAGAACTATCATCCTTTTTGACCTGGTTAGAGCGGGGTGAAGCTAAAGCCAGTTCCCC AGAAATGGACATTTCTGCAGACAGAGTCAAAGTGGAAGGTGAACTTCAGTTAATACAGGCACTGCAAAATGAAGTTGTATCCCAGGCCTCATTCTATAGC AAACTTTTGCAATTGAAGGAATCATTGTTCTCAGTAGCCTCCAAAGATGATGTGAAAATGATGAAACTACATTTGGAGCAGTTGGATGAGAGATGGAGAG ATTTACCACAGATCATTAACAAAAGGATTAATTTTCTTCAGTCTGTGGTTGCTGAACACCAGCAATTTGATGAGCTGCTGCTTTCCTTTTCTGTCTGGAT TAAACTGTTTCTCAGTGAATTACAAACTACCTCTGAGATTAGCATAATGGACCATCAAGTAGCCCTTACTCGGCATAAGGACCACGCAGCAGAAGTAGAG AGCAAAAAGGGCGAATTGCAGAGTCTGCAGGGTCACTTAGCAAAGTTGGGTTCTCTGGGCCGTGCTGAGGACCTCCACCTCCTGCAGGGAAAGGCTGAGG ACTGCTTCCAGCTGTTTGAGGAGGCCAGCCAGGTTGTGGAGAGGCGGCAGCTTGCCCTGTCCCATTTGGCAGAATTCCTCCAGAGCCATGCCTCTCTGTC CGGCATTCTCCGCCAGCTGAGGCAAACAGTGGAAGCAACCAACAGTATGAATAAGAACGAGTCTGATTTGATAGAAAAGGACCTCAATGATGCTCTTCAA AATGCTAAAGCATTAGAATCTGCTGCCGTCAGTCTGGATGGCATTCTTTCCAAAGCCCAATACCATCTGAAAATCGGGAGCTCTGAGCAAAGGACTTCCT GCAGAGCCACGGCTGATCAGCTCTGTGGAGAGGTAGAGAGGATCCAGAACCTTCTGGGAACCAAGCAGAGTGAGGCAGATGCTCTGGCAGTGTTGAAAAA AGCATTCCAAGACCAGAAAGAGGAGCTTCTGAAAAGCATTGAGGACATTGAAGAAAGGACTGACAAAGAGCGATTGAAAGAACCTACCCGCCAAGCTCTT CAGCAGAGGTTAAGAGTGTTTAATCAGCTAGAAGATGAATTGAATTCTCACGAGCATGAACTATGTTGGTTGAAAGACAAAGCCAAGCAAATTGCCCAGA AAGATGTAGCTTTTGCACCTGAAGTTGACAGGGAGATAAACCGCTTAGAGGTCACCTGGGATGATACCAAAAGACTAATTCATGAAAATCAGGGTCAGTG CTGTGGACTTATTGACTTAATGAGAGAATATCAGAACCTGAAATCAGCTGTATCTAAAGTCTTAGAAAATGCCAGCAGTGTGATTGTAACCAGAACTACC ATAAAAGATCAGGAGGATCTTAAATGGGCTTTTTCCAAGCATGAAACTGCCAAGAACAAAATGAATTACAAACAGAAAGACTTGGATAACTTTACCAGCA AAGGAAAACACTTGTTATCTGAGCTGAAGAAAATTCACAGTAGTGATTTCAGCTTGGTGAAAACAGACATGGAGAGCACCGTGGACAAATGGCTGGATGT ATCAGAGAAACTTGAAGAAAACATGGATAGGCTGAGAGTAAGCCTGTCCATTTGGGATGATGTACTGTCAACTAGAGATGAGATTGAGGGATGGTCAAAC AACTGCGTTCCACAGATGGCAGAAAACATCAGCAACCTGGATAACCACCTCAGAGCTGAAGAACTGCTTAAAGAATTTGAGTCTGAAGTTAAAAACAAAG CATTGAGATTGGAAGAACTGCATTCCAAAGTTAATGATCTGAAAGAATTAACTAAAAATCTAGAAACACCGCCAGACCTTCAGTTTATAGAAGCAGACTT AATGCAGAAACTGGAGCATGCCAAAGAAATAACTGAAGTAGCAAAAGGAACCCTGAAGGATTTCACGGCTCAAAGTACACAAGTGGAGAAGTTTATTAAT GACATAACAACATGGTTCACAAAAGTGGAAGAATCGTTGATGAACTGTGCCCAAAATGAGACTTGTGAAGCATTGAAAAAAGTCAAGGATATACAAAAAG AACTTCAAAGTCAACAAAGCAACATCAGCTCTACCCAAGAAAATCTCAATAGCTTGTGCCGCAAGTACCACTCAGCTGAGTTGGAGAGCCTGGGCCGTGC AATGACTGGTCTGATAAAGAAACATGAAGCCGTGAGCCAGTTGTGCTCCAAAACCCAGGCCAGCCTGCAGGAATCTCTGGAAAAACACTTCAGTGAGTCT ATGCAGGAATTCCAAGAATGGTTTTTGGGAGCAAAGGCAGCAGCAAAAGAATCATCAGATCGCACCGGTGACAGCAAAGTTCTAGAAGCAAAGCTCCATG ATCTTCAGAACATTTTGGACTCAGTCAGTGATGGGCAGAGCAAACTTGATGCAGTGACTCAAGAAGGACAAACTTTGTATGCACATTTGTCTAAACAAAT TGTCAGTAGCATTCAAGAACAAATCACAAAGGCCAATGAAGAGTTTCAAGCATTTCTGAAACAATGCCTTAAAGATAAGCAGGCTCTTCAAGACTGTGCT TCAGAACTTGGAAGCTTTGAAGATCAGCACAGAAAACTGAACTTATGGATCCATGAAATGGAAGAAAGGTTCAATACGGAAAACTTGGGAGAGAGTAAAC AGCACATTCCTGAGAAGAAAAATGAAGTTCATAAAGTTGAAATGTTTTTGGGAGAACTGCTGGCTGCAAGAGAGTCTCTTGATAAGCTTTCCCAGAGAGG GCAGCTTCTGAGTGAAGAAGGCCACGGTGCTGGGCAGGAGGGCCGCCTGTGTTCCCAGCTCCTCACAAGCCACCAGAACCTACTTAGAATGACCAAAGAG AAACTCCGGAGCTGCCAGGTGGCCCTTCAGGAGCACGAAGCCCTGGAGGAAGCACTGCAAAGCATGTGGTTCTGGGTGAAGGCCATTCAGGACAGACTGG CCTGTGCAGAGAGCACTCTTGGGAGCAAAGACACCCTGGAGAAACGGCTGTCACAAATACAGGATATTCTCCTGATGAAAGGTGAAGGGGAAGTTAAGTT GAATATGGCCATTGGCAAGGGGGAACAGGCCTTGAGAAGTAGCAACAAAGAAGGTCAGAGGGTGATTCAGACTCAGTTAGAGACCCTTAAAGAAGTGTGG GCTGACATCATGAGCTCCTCCGTCCACGCTCAAAGCACTTTAGAGTCTGTGATTAGCCAATGGAATGACTATGTAGAGAGGAAAAACCAGTTGGAGCAGT GGATGGAATCAGTGGATCAAAAAATAGAACATCCCTTACAACCACAGCCAGGTCTGAAAGAGAAGTTCGTCCTGCTTGACCACCTCCAGTCCATCCTGTC TGAGGCAGAAGATCACACGAGAGCCCTTCACCGTCTAATTGCGAAGTCCAGGGAGCTCTACGAAAAGACAGAGGATGAGTCTTTCAAGGACACAGCTCAA GAGGAGCTGAAAACACAGTTTAATGATATAATGACTGTTGCCAAGGAAAAAATGAGGAAAGTGGAAGAGATTGTGAAAGATCATCTAATGTATTTAGATG CGGTCCACGAGTTCACAGATTGGCTCCATTCAGCAAAGGAAGAACTTCACCGGTGGTCAGATATGTCTGGAGATTCATCAGCCACCCAGAAAAAGTTATC AAAAATTAAGGAGCTGATAGATTCCAGAGAGATTGGTGCAAGCCGTCTCAGCAGAGTGGAGTCGCTGGCTCCCGAAGTGAAACAGAACACAACTGCCAGT GGGTGTGAGCTCATGCACACGGAGATGCAGGCCCTGCGTGCCGACTGGAAGCAGTGGGAAGACAGTGTATTCCAAACGCAGAGCTGTTTGGAGAACCTGG TCAGCCAGATGGCCCTTTCGGAGCAGGAATTCTCAGGCCAAGTGGCTCAACTGGAGCAGGCCCTGGAACAGTTCAGTGCCCTTCTGAAAACCTGGGCTCA GCAGTTAACCCTCCTGGAAGGCAAGAACACGGATGAGGAGATAGTGGAATGCTGGCACAAAGGACAAGAGATACTGGATGCTTTGCAAAAAGCAGAGCCT AGAACAGAGGATCTCAAGTCTCAGCTGAATGAACTTTGTCGATTTTCCAGAGACCTGAGTACCTACAGTGGAAAAGTTTCTGGCTTGATTAAAGAGTATA ATTGTCTTTGTTTGCAAGCATCCAAGGGCTGCCAGAATAAAGAACAGATTTTACAGCAAAGATTTCGAAAGGCCTTCAGGGATTTCCAGCAGTGGTTGGT TAATGCAAAAATCACTACCGCCAAGTGTTTTGATATACCTCAAAATATAAGTGAAGTTTCAACTAGTCTTCAGAAAATACAGGAGTTTTTGTCAGAAAGT GAAAATGGACAGCACAAGCTAAACATGATGCTGTCTAAAGGGGAACTTCTGAGTACCCTGCTGACCAAAGAGAAAGCGAAAGGGATCCAGGCCAAAGTTA CAGCTGCAAAAGAAGATTGGAAAAATTTTCATTCAAATCTCCACCAAAAAGAATCTGCTCTAGAGAATCTAAAGATCCAAATGAAGGACTTTGAAGTAAG TGCTGAGCCTATCCAGGACTGGCTGAGTAAAACTGAGAAGATGGTCCATGAAAGCAGCAATCGCCTCTATGATCTGCCAGCAAAGAGGAGGGAGCAGCAG AAGCTCCAGTCTGTCCTTGAGGAAATACACTGCTACGAGCCTCAGCTCAACAGGCTGAAAGAGAAAGCTCAGCAGCTGTGGGAAGGACAAGCTGCCAGCA AGAGCTTTAGGCACAGAGTGTCGCAGCTGTCTTCTCAGTATCTAGCGCTAAGCAATTTAACAAAGGAGAAAGTGTCAAGACTGGATAGAATCGTTGCAGA ACACAATCAGTTCTCTCTTGGGATTAAAGAATTACAAGACTGGATGACGGATGCGATTCACATGCTGGATTCATACTGCCACCCGACATCCGACAAAAGT GTGCTGGACAGCAGGACGCTCAAGCTCGAGGCTCTATTATCAGTCAAACAGGAAAAAGAGATTCAGATGAAAATGATAGTGACCAGGGGAGAATCTGTCC TTCAGAATACTTCTCCAGAAGGCATTCCCACTATTCAGCAGCAGCTGCAGAGTGTGAAGGATATGTGGGCATCCCTTTTGTCTGCAGGGATTCGTTGTAA AAGCCAACTCGAAGGAGCTCTCTCCAAGTGGACAAGTTATCAGGATGGCGTTCGACAGTTCTCCGGTTGGATGGATAGTATGGAAGCCAACCTGAATGAA TCAGAAAGGCAGCATGCGGAGCTGCGGGATAAAACAACGATGCTCGGAAAAGCCAAGTTATTAAATGAAGAAGTGCTGAGTTACAGCAGCTTGCTGGAGA CCATCGAAGTCAAAGGGGCTGGCATGACAGAACACTATGTCACCCAGCTAGAACTCCAGGATCTACAGGAACGATACAGAGCCATCCAAGAGAGGGCCAA GGAAGCCGTAACCAAGTCTGAAAAACTTGTCCGCCTGCACCAAGAGTATCAGAGAGACCTAAAGGCATTTGAAGTTTGGTTGGGGCAAGAACAAGAAAAG CTCGACCAGTATTCAGTTCTTGAAGGTGATGCCCACACTCATGAGACAACATTGCGTGATCTTCAGGAGCTACAGGTACACTGTGCAGAGGGGCAGGCCC TGTTGAACTCAGTGCTGCACACCAGAGAGGATGTGATCCCATCAGGTATCCCACAGGCAGAGGACCGGGCTTTAGAGTCTCTCCGGCAAGACTGGCAGGC TTACCAGCACAGGCTGTCCGAGACTCGAACTCAGTTCAATAACGTGGTGAACAAATTGAGGCTAATGGAGCAAAAGTTTCAGCAAGTAGATGAATGGCTC AAAACAGCAGAGGAGAAAAAGTGGCACGAAGAAGTGACTGCATACAGAGATGAAGTTGAGGAAGTGGGAGCTAGAGCTCAGGAGATACTGGACGAGAGCC ACGTGAACAGCAGAATGGGTTGCCAGGCCACCCAGCTGACTTCCAGATACCAGGCCCTGCTTCTCCAAGTGCTGGAACAAATAAAATTCCTGGAGGAGGA GATTCAGAGTTTGGAGGAATCAGAATCATCCCTCAGTTCCTATTCTGATTGGTATGGCTCTACTCATAAAAACTTCAAGAATGTGGCTACCAAGATTGAC AAAGTAGATACAGTAATGATGGGGAAGAAATTGAAGACGTTGGAGGTTTTGCTCAAAGACATGGAGAAAGGTCACAGTTTGCTGAAATCAGCCCGGGAGA AAGGAGAGAGGGCTGTTAAATACTTGGAGGAAGGCGAGGCAGAGAGGTTAAGAAAGGAGATTCATGATCACATGGAGCAGTTGAAGGAACTGACCAGCAC TGTCCGGAAAGAACACATGACGCTGGAAAAAGGTCTTCATTTAGCAAAGGAATTCTCAGATAAATGCAAAGCACTGACACAGTGGATAGCAGAATACCAG GAAATTCTACATGTTCCTGAAGAACCCAAAATGGAATTATATGAGAAAAAAGCTCAGTTATCTAAATACAAGTCACTTCAACAAACGGTGCTGTCCCATG AACCATCAGTAAAGTCAGTGAGAGAGAAGGGTGAAGCTCTTTTGGAACTGGTGCAGGACGTCACTTTAAAGGACAAAATAGATCAACTTCAAAGTGATTA CCAGGACCTGTGCAGCATAGGAAAGGCAATGATGGAAGAAATTGCTGGTTTTGAAGACCGTTTGAACAATCTTCAAATGAAAGGTGATACTTTGATTGGC CAATGTGCAGACCACCTGCAAGCGAAACTTAAACAAAACGTGCATGCTCATCTGCAGGGCACAAAGGACAGCTACTCAGCGATCTGCAGCACAGCTCAGA GGATGTACCAGAGTTTGGAACACGAACTTCAGAAGCACGTCAGCCGACAAGACACCCTGCAGCAGTGCCAGGCCTGGCTTTCTGCAGTCCAGCCGGATTT AGAGCCAAGTCCTCAACCACCTCTTAGTAGGGCAGAAGCCATTAAGCAGGTCAAACACTTCAGAGCTTTGCAAGAGCAGGCAAGGACCTACCTAGATCTC CTTTGCTCCATGTGTGACCTGTCAAATGCTTCGGTGAAAACCACAGCAAAAGACATTCAACAAACAGAGCAAACGATTGAACAAAAGCTTGTCCAGGCCC AGAACTTAACTCAGGGCTGGGAAGAGATCAAGCACCTGAAGTCTGAGCTCTGGATTTACCTGCAAGATGCTGATCAGCAACTGCAGAACATGAAGAGGAG GCACTCTGAGCTGGAGCTGAACATTGCACAGAACATGGTTTCACAAGTTAAGGATTTTGTTAAGAAACTACAGAGCAAACAGGCATCCGTGAACACCATA ATAGAAAAGGTGAATAAGTTAACAAAGAAGGAGGAATCGCCTGAACACAAGGAAATAAATCATTTAAATGATCAGTGGCTCGATTTGTGCCGTCAGTCTA ACAACCTGTGCTTGCAAAGGGAAGAGGATCTTCAGAGAACAAGAGATTACCATGACTGTATGAATGTTGTTGAAGTGTTCCTAGAAAAATTTACTACAGA ATGGGATAACTTGGCCAGATCTGATGCAGAGAGTACAGCTGTCCACCTGGAAGCTTTGAAAAAGTTAGCATTGGCATTGCAGGAGAGAAAGTATGCTATT GAAGATCTGAAAGATCAAAAGCAGAAAATGATAGAGCATCTGAATTTAGATGACAAGGAGTTAGTCAAAGAACAGACGAGTCATTTAGAGCAACGTTGGT TTCAGCTTGAGGACCTCATTAAAAGGAAAATCCAAGTGTCAGTCACCAACTTGGAGGAGTTAAATGTGGTGCAGTCCAGATTTCAGGAGCTAATGGAGTG GGCAGAAGAGCAACAACCCAACATCGCCGAGGCCCTTAAGCAGAGCCCTCCTCCAGATATGGCTCAGAACCTTCTCATGGATCACCTGGCCATCTGCAGT GAACTGGAGGCCAAGCAGATGCTCCTGAAATCGCTTATAAAGGACGCAGACAGGGTCATGGCAGATCTTGGTCTCAATGAGCGACAGGTCATCCAGAAGG CTCTCTCTGATGCACAAAGCCACGTGAATTGTCTCAGTGACTTAGTGGGCCAGCGAAGAAAGTACTTAAACAAAGCCTTGTCCGAGAAAACCCAGTTTCT CATGGCAGTGTTCCAGGCCACCAGCCAAATTCAGCAACATGAGCGAAAGATAATGTTCCGTGAACACATCTGTCTGTTACCAGATGATGTGAGCAAACAA GTCAAAACATGTAAGAGTGCACAAGCCAGCCTCAAGACTTACCAAAATGAAGTCACTGGACTTTGGGCCCAGGGTCGCGAACTAATGAAGGAAGTCACAG AGCAGGAAAAGAGTGAAGTGCTGGGGAAGCTTCAGGAATTGCAGAGTGTCTATGACAGTGTTTTACAAAAGTGCAGTCACCGGTTACAAGAACTAGAGAA GAATTTGGTTTCTAGGAAGCATTTTAAGGAAGATTTTGATAAAGCTTGCCACTGGCTAAAACAAGCAGATATTGTTACATTTCCTGAAATCAACCTAATG AATGAGAGTTCTGAGCTTCATACACAACTGGCTAAATACCAAAACATTCTTGAACAATCTCCAGAATATGAAAATCTTCTACTTACGCTGCAGAGAACTG GGCAGACCATATTACCATCGCTGAATGAAGTCGATCATTCCTACCTCAGTGAAAAGCTAAATGCTTTGCCTCGACAATTTAATGTAATTGTTGCCTTGGC TAAAGACAAGTTCTATAAAGTCCAGGAAGCAATTCTTGCTCGGAAGGAATATGCTTCCTTGATTGAGTTGACAACCCAGTCTCTGAGTGAACTTGAAGCC CAATTCTTGAGGATGAGCAAAGTTCCCACCGACCTGGCCGTTGAGGAGGCTCTTTCTCTGCAAGATGGTTGCAGAGCCATTCTGGACGAGGTGGCGGGCC TTGGGGAGGCGGTGGATGAACTGAACCAGAAAAAAGAAGGTTTTCGCAGCACAGGTCAGCCTTGGCAGCCAGACAAGATGCTGCACCTTGTCACCTTATA TCACAGGCTGAAGCGACAAACAGAACAGAGGGTTAGCTTATTAGAAGACACCACCAGTGCTTACCAAGAACACGAGAAGATGTGCCAACAGCTGGAGAGA CAACTGAAGTCTGTAAAAGAGGAGCAGTCCAAAGTGAATGAGGAAACGCTGCCTGCAGAGGAGAAGCTCAAAATGTATCACTCCCTGGCAGGAAGTCTCC AGGACTCAGGGATTGTACTGAAACGAGTAACCATACATCTTGAAGATCTTGCCCCACACCTTGACCCCTTGGCTTATGAGAAAGCCAGGCATCAGATCCA GTCCTGGCAAGGGGAGTTAAAACTGTTGACTTCTGCCATTGGTGAGACGGTGACAGAATGTGAGAGCCGAATGGTGCAGAGTATAGACTTCCAGACTGAG ATGAGTCGCTCCCTGGACTGGCTGAGGAGAGTGAAGGCAGAGCTCAGTGGGCCGGTGTACCTAGACCTCAACCTGCAGGACATCCAAGAGGAAATCAGAA AAATCCAAATTCATCAGGAAGAGGTCCAGTCCAGCTTGAGAATCATGAATGCGCTGAGTCACAAGGAAAAGGAGAAGTTCACAAAGGCCAAGGAGCTGAT TTCTGCGGATTTAGAACACAGCCTCGCTGAGCTCTCAGAGCTGGATGGAGACATCCAGGAAGCCTTACGCACCAGACAGGCTACCTTGACTGAAATATAT AGCCAGTGTCAAAGGTATTATCAGGTATTTCAAGCAGCCAATGACTGGCTTGAGGATGCCCAAGAATTGTTACAGCTGGCAGGCAATGGCCTAGACGTGG AGAGCGCAGAGGAAAATCTCAAAAGCCACATGGAATTTTTCAGTACAGAGGATCAGTTCCATAGTAACCTGGAGGAGCTCCACAGCCTGGTAGCCACCCT GGACCCACTCATCAAGCCAACCGGCAAAGAAGACCTAGAACAGAAAGTGGCTTCTCTGGAACTCAGGAGCCAGAGGATGAGCCGGGACTCTGGTGCCCAA GTGGATCTCTTGCAGAGATGCACAGCTCAATGGCACGATTACCAGAAAGCAAGGGAAGAGGTTATTGAATTGATGAATGATACAGAAAAGAAATTGTCTG AGTTTTCTTTGTTGAAGACTTCGTCTAGTCATGAAGCGGAAGAAAAATTGTCAGAACACAAGGCTTTAGTGTCAGTGGTTAACTCTTTCCATGAGAAAAT TGTGGCCCTTGAGGAAAAAGCTTCACAACTGGAGAAAACCGGAAATGATGCCAGCAAAGCCACCCTGAGCAGGTCAATGACCACCGTCTGGCAGCGCTGG ACACGCCTTCGAGCTGTGGCCCAGGACCAGGAGAAGATCCTGGAAGATGCAGTGGATGAGTGGACGGGCTTTAACAACAAGGTTAAAAAGGCCACTGAAA TGATTGATCAGCTGCAAGATAAGTTACCTGGAAGTTCAGCAGAGAAAGCATCGAAAGCAGAGCTCTTAACTCTTCTTGAATACCACGACACGTTCGTTCT GGAGCTGGAGCAGCAGCAGTCGGCCTTGGGCATGCTGCGGCAGCAAACCCTGAGCATGCTCCAGGATGGAGCCGCCCCAACCCCTGGGGAAGAGCCTCCG CTCATGCAGGAAATCACCGCCATGCAAGATCGGTGCCTGAACATGCAGGAGAAAGTGAAGACTAATGGAAAGTTGGTGAAGCAAGAGCTGAAGGACCGAG AAATGGTGGAGACTCAGATCAATTCTGTGAAATGTTGGGTTCAGGAAACGAAAGAATATTTAGGGAATCCAACAATAGAAATAGATGCTCAACTTGAAGA ACTTCAGATTCTCCTAACAGAAGCCACAAATCACCGACAGAACATTGAAAAAATGGCAGAAGAACAGAAGGAGAAGTACTTAGGTCTTTATACCATATTA CCTTCTGAACTCTCCCTTCAGTTGGCTGAAGTGGCGTTAGATCTAAAGATCCGAGATCAGATCCAAGACAAAATAAAAGAAGTTGAGCAGAGCAAGGCCA CGAGCCAGGAACTCAGCCGGCAAATTCAGAAGTTAGCTAAAGACCTCACAACTATTCTAACTAAGCTGAAAGCGAAGACAGATAATGTAGTTCAAGCTAA AACTGACCAAAAGGTGCTGGGAGAGGAATTAGATGGCTGTAATTCAAAGTTAATGGAATTAGATGCAGCAGTACAGAAATTCTTGGAACAGAATGGCCAA CTGGGTAAGCCACTGGCCAAGAAGATAGGAAAACTGACTGAACTTCACCAGCAGACCATTAGACAAGCTGAGAATCGGCTCTCCAAGCTCAATCAGGCAG CATCACATTTAGAAGAATACAATGAAATGCTTGAATTAATTTTGAAGTGGATTGAAAAAGCTAAAGTCTTGGCTCATGGAACTATTGCATGGAATTCTGC AAGCCAGCTTCGGGAACAATATATTTTGCATCAGACCCTGCTAGAAGAATCCAAAGAAATTGACAGTGAGCTGGAAGCAATGACTGAGAAATTACAGTAC CTCACTAGCGTGTACTGTACAGAAAAAATGTCTCAGCAAGTGGCAGAACTGGGACGGGAGACTGAGGAGTTGCGACAGATGATCAAAATTCGTTTGCAGA ACCTCCAAGATGCAGCTAAGGATATGAAAAAATTTGAAGCAGAGTTGAAAAAGTTACAAGCTGCCTTGGAGCAAGCCCAGGCAACACTGACTTCTCCAGA AGTTGGACGTCTCAGTCTCAAGGAGCAGCTCTCTCATCGGCAGCATTTGTTGTCTGAGATGGAGTCACTGAAGCCGAAGGTGCAAGCAGTGCAGCTCTGC CAGAGTGCCCTCCGGATCCCCGAGGATGTGGTTGCCAGCTTACCTCTCTGTCATGCTGCTCTGCGGCTGCAGGAAGAGGCCAGCCGGCTGCAGCACACCG CCATCCAGCAGTGTAACATCATGCAGGCAGCTGTGGTACAATATGAACAATATGAGCAAGAAATGAAACATCTCCAGCAACTGATAGAAGGAGCTCACAG AGAGATTGAGGATAAACCTGTTGCCACCAGTAACATACAGGAGCTGCAGGCTCAGATTTCTCGGCATGAGGAGCTGGCGCAGAAAATTAAGGGCTACCAG GAGCAGATCGCTTCTTTGAATTCCAAGTGCAAGATGCTGACGATGAAAGCCAAGCACGCCACCATGCTGCTGACGGTGACCGAGGTCGAGGGGCTGGCGG AAGGGACAGAGGACCTGGATGGGGAGCTCCTCCCCACGCCTTCGGCCCACCCCTCTGTGGTCATGATGACTGCAGGTCGCTGTCACACTTTGCTGTCACC GGTCACTGAGGAGTCTGGGGAGGAGGGAACCAACAGTGAGATTTCCTCTCCACCTGCCTGTCGCTCCCCTTCACCTGTGGCTAATACAGATGCTTCTGTT AACCAGGACATTGCATATTACCAAGCCTTGTCTGCTGAGAGGTTGCAGACAGATGCTGCAAAAATTCACCCCAGCACATCCGCATCCCAGGAGTTCTATG AACCGGGATTGGAGCCATCCGCTACTGCCAAACTGGGTGATTTGCAGCGTTCTTGGGAAACCTTAAAGAATGTGATCAGTGAGAAGCAGCGCACACTCTA TGAAGCTTTGGAACGCCAGCAGAAGTACCAGGACTCCCTCCAGTCCATCTCTACGAAGATGGAGGCCATTGAGCTGAAACTCAGTGAGAGCCCAGAGCCT GGCAGGAGTCCAGAAAGCCAGATGGCTGAACATCAGGCATTGATGGATGAGATTCTCATGCTCCAGGATGAAATCAATGAGCTCCAGTCCTCTCTCGCAG AGGAGCTGGTATCCGAGTCTTGTGAGGCCGACCCTGCGGAGCAGCTGGCCTTGCAGTCCACGCTCACTGTCTTAGCCGAGCGAATGTCCACCATCAGGAT GAAAGCCTCGGGGAAACGGCAGCTTTTGGAGGAGAAGTTGAATGATCAGCTGGAGGAACAAAGGCAGGAACAGGCCCTGCAGAGGTATCGCTGTGAAGCC GATGAGCTGGACAGCTGGCTCTTGAGTACCAAGGCCACTCTGGACACTGCGCTGAGTCCACCCAAGGAGCCCATGGACATGGAGGCCCAGCTTATGGACT GCCAGAATATGCTGGTGGAAATAGAGCAGAAGGTGGTGGCTTTATCAGAACTGTCAGTCCACAATGAGAACCTGCTGCTGGAGGGCAAAGCTCACACCAA GGACGAGGCCGAGCAGCTGGCTGGAAAGCTGAGAAGGCTCAAGGGGAGCCTGCTGGAGCTGCAGAGAGCCCTGCATGATAAGCAGCTCAACATGCAGGGA ACAGCACAGGAGAAGGAGGAGAGCGATGTTGACCTAACAGCCACGCAGAGCCCCGGCGTCCAGGAATGGCTGGCCCAAGCTCGCACCACATGGACCCAGC AGCGGCAGAGCAGTCTCCAGCAACAAAAAGAGTTAGAACAGGAATTAGCCGAGCAGAAGAGTCTCCTTCGCTCAGTAGCCAGTCGTGGAGAGGAGATTCT AATTCAACATTCGGCGGCAGAGACCTCTGGTGATGCTGGCGAAAAACCTGATGTGTTATCCCAGGAGTTGGGGATGGAAGGGGAGAAATCATCCGCTGAA GACCAGATGAGAATGAAATGGGAAAGCCTACATCAAGAATTTAGTACCAAGCAGAAACTACTACAGAATGTTCTGGAACAGGAACAAGAGCAAGTGCTTT ATAGCAGGCCAAATCGACTCTTGTCTGGTGTGCCACTGTACAAAGGGGACGTGCCAACCCAAGATAAATCTGCAGTTACATCTTTGCTGGATGGACTGAA CCAAGCCTTCGAGGAGGTTTCATCCCAGAGTGGAGGGGCAAAGAGGCAGAGTATACACTTGGAGCAGAAGTTGTATGATGGAGTCTCAGCCACCTCTACT TGGTTGGATGACGTTGAAGAACGTTTATTTGTTGCCACAGCACTTTTACCAGAAGAAACAGAGACTTGTCTCTTCAACCAAGAGATTCTTGCCAAAGACA TTAAGGAAATGTCTGAAGAAATGGATAAGAACAAAAACTTGTTTTCCCAAGCTTTTCCAGAGAATGGTGATAATCGAGATGTTATTGAAGATACTTTGGG TTGTCTTTTGGGCAGGTTATCCTTGCTAGACTCAGTAGTGAATCAACGATGTCATCAGATGAAAGAAAGACTTCAGCAAATACTAAATTTCCAGAATGAT CTGAAAGTGCTGTTTACATCACTGGCTGACAACAAATACATCATTCTGCAAAAACTGGCAAATGTGTTTGAACAGCCCGTAGCAGAACAAATAGAGGCAA TACAACAGGCTGAAGATGGACTCAAAGAATTTGATGCAGGAATCATTGAATTAAAGAGGCGTGGTGACAAGCTACAGGTCGAGCAGCCGTCCATGCAAGA ACTCTCCAAGCTCCAGGACATGTATGATGAGCTGATGATGATCATTGGCTCCCGGAGGAGTGGTCTGAATCAGAACCTTACACTCAAGAGTCAGTATGAG AGGGCCCTACAAGATCTGGCTGACCTGCTAGAAACTGGTCAGGAGAAGATGGCAGGAGACCAGAAAATCATCGTGTCTTCCAAAGAGGAAATCCAGCAAC TACTTGACAAACATAAGGAATACTTTCAGGGCCTGGAATCTCATATGATCTTGACTGAAACACTCTTCAGAAAGATAATCAGCTTTGCAGTCCAAAAGGA AACCCAGTTCCATACAGAGCTGATGGCTCAGGCTTCTGCTGTACTGAAACGGGCTCACAAGAGGGGTGTGGAGCTGGAGTACATTCTAGAGACGTGGTCC CATCTGGATGAGGACCAGCAGGAGCTCAGCAGACAGCTGGAGGTGGTGGAAAGCAGCATCCCAAGCGTGGGTCTGGTGGAGGAGAACGAGGACAGGCTTA TTGACCGCATAACACTCTACCAGCATTTAAAATCTAGCCTTAATGAATACCAGCCCAAATTATATCAAGTATTAGATGATGGGAAACGACTTCTGATATC CATCAGCTGCTCAGATCTAGAAAGCCAACTAAATCAACTTGGAGAGTGCTGGCTAAGTAACACCAATAAAATGTCTAAGGAACTTCACAGACTGGAAACA ATATTGAAACACTGGACCAGATATCAAAGTGAATCTGCAGATCTAATTCACTGGTTACAATCTGCAAAAGACCGGCTAGAATTTTGGACTCAGCAATCTG TGACAGTCCCACAAGAGCTGGAAATGGTCCGTGATCATCTAAATGCTTTCCTGGAGTTTTCTAAAGAAGTGGATGCCCAATCTTCCCTGAAATCATCTGT TCTGAGTACTGGAAATCAGCTCCTTCGACTAAAAAAGGTGGACACAGCCACGCTGCGCTCTGAGCTGTCGCGCATTGATAGCCAGTGGACTGACCTGCTA ACCAATATCCCAGCCGTCCAGGAGAAGCTCCACCAGCTCCAGATGGATAAACTGCCTTCCCGCCATGCCATTTCTGAAGTCATGAGTTGGATTTCTCTAA TGGAAAATGTTATTCAGAAGGATGAAGATAATATTAAAAATTCCATAGGTTACAAGGCAATTCATGAATACCTTCAGAAATATAAGGGTTTTAAGATAGA CATTAACTGTAAACAGCTGACAGTGGATTTTGTGAACCAGTCCGTGCTACAAATCAGCAGTCAGGATGTGGAAAGTAAGCGTAGTGATAAGACTGATTTT GCTGAGCAACTTGGAGCAATGAATAAAAGTTGGCAAATTCTGCAAGGTCTAGTAACTGAGAAGATCCAGCTGTTGGAAGGCTTATTGGAATCTTGGTCAG AATATGAAAATAATGTACAATGTCTGAAAACATGGTTTGAAACCCAGGAAAAGAGACTAAAACAACAGCATCGAATTGGAGATCAGGCTTCTGTTCAAAA TGCACTGAAAGACTGTCAGGATCTGGAAGATTTGATTAAAGCAAAAGAAAAAGAAGTAGAGAAAATTGAGCAGAATGGACTTGCTTTGATTCAGAACAAG AAAGAAGACGTCTCTAGCATTGTCATGAGCACACTGCGAGAGCTCGGCCAAACCTGGGCAAATTTAGATCACATGGTTGGACAATTAAAGATACTGCTGA AATCAGTGCTTGACCAATGGAGTAGTCACAAAGTGGCCTTTGACAAGATAAACAGTTACCTCATGGAGGCCAGATACTCTCTTTCCCGATTCCGTCTGCT GACTGGCTCCTTAGAAGCTGTGCAAGTTCAGGTGGACAATCTTCAGAATCTCCAAGATGATCTGGAAAAACAGGAAAGGAGCTTACAGAAATTTGGCTCT ATCACCAACCAATTATTAAAAGAGTGTCACCCACCCGTGACAGAAACTCTTACCAATACACTGAAAGAAGTCAACATGAGATGGAATAACTTGCTGGAAG AGATTGCTGAGCAGCTACAGTCCAGCAAGGCCCTACTTCAGCTTTGGCAAAGATACAAGGACTACTCCAAACAGTGTGCTTCGACAGTTCAGCAGCAGGA GGATCGAACCAATGAGCTGTTGAAGGCAGCCACAAACAAGGACATTGCCGATGATGAGGTTGCCACATGGATTCAAGATTGCAACGACCTCCTCAAAGGA CTGGGCACAGTTAAAGATTCCCTCTTTTTTCTCCATGAGCTGGGAGAGCAACTGAAGCAACAAGTGGATGCTTCCGCAGCATCAGCTATTCAATCGGATC AACTCTCTTTGAGTCAACACTTGTGTGCCCTGGAGCAAGCTCTCTGCAAACAGCAGACTTCATTACAGGCTGGAGTTCTTGATTATGAAACCTTTGCCAA GAGTTTAGAAGCTTTGGAGGCCTGGATAGTGGAAGCTGAAGAAATACTACAAGGGCAGGACCCTAGCCACTCATCTGACCTCTCCACAATCCAGGAAAGG ATGGAAGAACTTAAGGGACAGATGTTAAAATTCAGCAGCATGGCTCCAGATTTAGACCGTCTAAATGAGCTTGGATATAGGTTACCCTTGAATGATAAGG AAATCAAAAGAATGCAGAATCTGAACCGCCATTGGTCTCTGATCTCCTCTCAGACTACAGAAAGATTCAGCAAGTTGCAGTCATTTTTGCTACAACATCA GACTTTCTTGGAAAAATGTGAAACATGGATGGAATTCCTAGTTCAGACAGAACAAAAGTTAGCAGTAGAGATTTCAGGAAATTATCAGCACCTTTTGGAA CAGCAGAGAGCACACGAGTTGTTTCAAGCCGAGATGTTCAGTCGTCAGCAGATTTTGCACTCAATCATTATTGATGGGCAACGTCTTCTAGAACAAGGTC AAGTTGATGACAGGGATGAATTCAACCTGAAATTGACACTCCTCAGTAATCAATGGCAGGGAGTGATTCGCAGGGCCCAGCAGAGGCGGGGGATCATTGA CAGCCAGATTCGCCAGTGGCAGCGCTATAGGGAGATGGCAGAAAAGCTTCGTAAATGGTTGGTTGAAGTGTCCTACCTCCCCATGAGTGGTCTCGGAAGT GTTCCTATACCACTGCAACAAGCAAGGACCCTCTTTGATGAAGTGCAGTTCAAAGAAAAAGTGTTTCTGCGGCAACAAGGCAGCTACATCCTGACTGTGG AGGCTGGCAAGCAACTCCTTCTCTCGGCGGACAGTGGCGCTGAGGCCGCCTTGCAGGCCGAACTCGCTGAAATCCAAGAGAAATGGAAATCAGCCAGCAT GCGGCTGGAAGAACAGAAGAAAAAACTAGCCTTCTTGTTGAAAGACTGGGAAAAATGTGAGAAAGGAATAGCAGATTCCCTGGAGAAACTACGAACTTTC AAAAAGAAGCTTTCGCAGTCTCTCCCGGATCACCATGAAGAGCTCCATGCAGAACAAATGCGTTGCAAGGAATTAGAAAATGCAGTTGGGAGCTGGACAG ATGACTTGACCCAGTTGAGCCTGCTGAAGGACACCCTCTCTGCCTATATCAGTGCTGATGATATCTCCATTCTTAATGAACGCGTAGAGCTTCTGCAAAG GCAGTGGGAAGAACTATGCCACCAGCTCTCCTTAAGGCGGCAGCAAATAGGTGAAAGATTGAATGAATGGGCAGTCTTCAGTGAAAAGAACAAGGAACTC TGTGAGTGGTTGACTCAAATGGAAAGCAAAGTTTCTCAGAATGGAGACATTCTCATTGAAGAAATGATAGAGAAGCTCAAGAAGGATTATCAAGAGGAAA TTGCTATTGCTCAAGAGAACAAAATACAGCTCCAACAAATGGGAGAACGACTTGCTAAAGCCAGCCATGAAAGCAAAGCATCTGAGATTGAATACAAGCT GGGAAAGGTCAACGACCGGTGGCAGCATCTCCTGGACCTCATTGCAGCCAGGGTGAAGAAGCTGAAGGAGACCCTGGTAGCCGTGCAGCAGCTTGATAAG AACATGAGCAGCCTGAGGACCTGGCTCGCTCACATCGAGTCAGAGCTGGCCAAGCCAATAGTCTACGATTCCTGTAACTCGGAAGAAATACAGAGAAAGC TTAATGAGCAGCAGGAGCTTCAGAGAGACATAGAGAAGCACAGTACAGGTGTTGCATCTGTCCTCAACCTGTGTGAAGTCCTGCTGCACGACTGTGACGC CTGTGCCACTGATGCCGAGTGTGACTCTATACAGCAGGCTACGAGAAACCTGGACCGGCGGTGGAGAAACATTTGTGCTATGTCCATGGAAAGGAGGCTG AAAATCGAAGAGACGTGGCGATTGTGGCAGAAATTTCTGGATGACTATTCACGTTTTGAAGATTGGCTGAAGTCTTCAGAAAGGACAGCTGCTTTTCCCA GCTCTTCTGGGGTGATCTATACAGTTGCCAAGGAAGAACTAAAGAAATTTGAGGCTTTCCAGCGACAGGTCCACGAGTGCCTGACGCAGCTGGAACTGAT CAACAAGCAGTACCGCCGCCTGGCCAGGGAGAACCGCACTGATTCAGCATGTAGCCTCAAACAGATGGTTCACGAAGGCAACCAGAGATGGGACAACCTG CAAAAGCGTGTCACCTCCATCTTGCGCAGACTCAAGCATTTTATTGGCCAGCGTGAGGAGTTTGAGACTGCGCGGGACAGCATTCTGGTCTGGCTCACAG AGATGGATCTGCAGCTCACTAATATTGAACATTTTTCTGAGTGTGATGTTCAAGCTAAAATAAAGCAACTCAAGGCCTTCCAGCAGGAAATTTCACTGAA CCACAATAAGATTGAGCAGATAATTGCCCAAGGAGAACAGCTGATAGAAAAGAGTGAGCCCTTGGATGCAGCGATCATCGAGGAGGAACTAGATGAGCTC CGACGGTACTGCCAGGAGGTCTTCGGGCGTGTGGAAAGATACCATAAGAAACTGATCCGCCTGCCTCTCCCAGACGATGAGCACGACCTCTCAGACAGGG AGCTGGAGCTGGAAGACTCTGCAGCTCTGTCGGACCTGCACTGGCACGACCGCTCTGCAGACAGCCTGCTTTCTCCACAGCCTTCCTCCAATCTCTCCCT CTCGCTCGCTCAGCCCCTCCGGAGCGAGCGGTCAGGACGAGACACCCCGGCTAGTGTGGACTCCATCCCCCTGGAGTGGGATCACGACTATGACCTCAGT CGGGACCTGGAGTCTGCAATGTCCAGAGCTCTGCCCTCTGAGGATGAAGAAGGTCAGGATGACAAAGATTTCTACCTCCGGGGAGCTGTTGGCTTATCAG ATGTAATGATCCCCGAAAGCCCTGAGGCCTATGTAAAACTCACAGAAAATGCAATCAAAAATACCTCCGGGGACCACAGTGCCCTAGAGTCACAGATCCG ACAACTGGGCAAAGCCCTGGATGATAGCCGTTTTCAGATACAGCAAACCGAAAATATCATTCGCAGCAAAACTCCCACGGGGCCGGAGCTAGACACCAGC TACAAAGGCTACATGAAACTGCTGGGCGAATGCAGTAGCAGTATAGACTCCGTGAAGAGACTGGAGCACAAACTGAAGGAGGAAGAGGAGAGCCTTCCTG GCTTTGTTAACCTGCATAGTACCGAAACCCAAACGGCTGGTGTGATTGACCGATGGGAGCTTCTCCAGGCCCAGGCATTGAGCAAGGAGTTGAGGATGAA GCAGAACCTCCAGAAGTGGCAGCAGTTTAACTCAGACTTGAACAGCATCTGGGCCTGGCTGGGGGACACGGAGGAGGAGTTGGAACAGCTCCAGCGTCTG GAACTCAGCACTGACATCCAGACCATCGAGCTCCAGATCAAAAAGCTCAAGGAGCTCCAGAAAGCTGTGGACCACCGCAAAGCCATCATCCTCTCCATCA ATCTCTGCAGCCCTGAGTTCACCCAGGCTGACAGCAAGGAGAGCCGGGACCTGCAGGATCGCTTGTCGCAGATGAATGGGCGCTGGGACCGAGTGTGCTC TCTGCTGGAGGAGTGGCGGGGCCTGCTGCAGGATGCCCTGATGCAGTGCCAGGGTTTCCATGAAATGAGCCATGGTTTGCTTCTTATGCTGGAGAACATT GACAGAAGGAAAAATGAAATTGTCCCTATTGATTCTAACCTTGATGCAGAGATACTTCAGGACCATCACAAACAGCTTATGCAAATAAAGCATGAGCTGT TGGAATCCCAACTCAGAGTAGCCTCTTTGCAAGACATGTCTTGCCAACTACTGGTGAATGCTGAAGGAACAGACTGTTTAGAAGCCAAAGAAAAAGTCCA TGTTATTGGAAATCGGCTCAAACTTCTCTTGAAGGAGGTCAGTCGTCATATCAAGGAACTGGAGAAGTTATTAGACGTGTCAAGTAGTCAGCAGGATTTG TCTTCCTGGTCTTCTGCTGATGAACTGGACACCTCAGGGTCTGTGAGTCCCACATCAGGAAGGAGCACCCCAAACAGACAGAAAACGCCACGAGGCAAGT GTAGTCTCTCACAGCCTGGACCCTCTGTCAGCAGTCCACATAGCAGGTCCACAAAAGGTGGCTCCGATTCCTCCCTTTCTGAGCCAGGGCCAGGTCGGTC CGGCCGCGGCTTCCTGTTCAGAGTCCTCCGAGCAGCTCTTCCCCTTCAGCTTCTCCTGCTCCTCCTCATCGGGCTTGCCTGCCTTGTACCAATGTCAGAG GAAGACTACAGCTGTGCCCTCTCCAACAACTTTGCCCGGTCATTCCACCCCATGCTCAGATACACGAATGGCCCTCCTCCACTCTGAACTAAGCAGATGC CATCTGCAGAAGTGCTGGTAGCATAAGGAGGATCGGGTCATAAGCAATCCCAAACTACCAACAAGAGGACCTTGATCTTGGCGAAAGCCCTCGGTGTGGC AGCTTTAGCCCTCCTCCAGATCACATGTGTGCAAATTATGGCTTCAGAGGTGGAAGATAAACAGTGACGGGGGAACAAACAGACAACAAGAAGGTTTGGA AGAAATCTGGTTTGAGACTCTGAACCTTAGCACTAAGGAGATTGAGTAAGGACCTCCAAAGTTCCCCGGACTCATGAATTCTGGGCCCTTGGCCCATTCT GTGCACAGCCAAGGACTTCAGTAGACCATCTGGGCAGCTTTCCCATGGTGCTGCTCCAACCATCAGATAAATGACCCTCCCAAGCACCATGTCAGTGTCG TACAATCTACCAACCAACCAGTGCTGAAGAGATTTTAGAACCTTGTAACATACAATTTTTAAGAGCTTATATGGCAGCTTCCTTTTTACCTTGTTTTCCT TTGGGGCATGATGTTTTAACCTTTGCTTTAGAAGCACAAGCTGTAAATCTAAAAGGCACTTTTTTTTAGAGGTATAAAGAAAAACTAGATGTAATAAATA AGATCATGGAAGGCTTTATGTGAAAAAAGTTGAATGTTATAGTAAAAAAAAAAAGATATTTATGTATGTACAGTTTGCTAAAGCCAAGTTTTGTTTGTAT TGATTTCTTTGCATTTATTATAGATATTATAAAAT

refseq_SYNE1.F5 (forward primer)
refseq_SYNE1.R5 (reverse primer)
Single exon skipping

Frame 0

RPPAAAG*DCCPLSPGRLGSRSPADRARSRRQG GRTAAHPRGPAEPGRREPGGSVRSLRLAAGKLNE AEREGS*VHVRGQS*NGRRKRSSSVFGRAASLL SAAKAWNSFMTE*I*KSPSMFSRVV*PCAASSE ESLGVGFVLPEGPWQPPEGPPGVLGISPM*CRGC KMSKR*YKNELSQNGSTLIWPSGNLQWWWTIFL KT*KMVLNCLPFWRSCLGRNCLVNKDAG*SESM LWLTLARHSSSSKEESPCTEDHRLN*STLTPPI* LMADPQ*FLD*CGPLFYISRLKS*PATCPSSSL CPAAHPPWTA*LALRLPAHQVNGR*PPRSKEML RRLY*SGFSTQLASRLE*K*KILGRVGEAGLPFI QLFMPFDRNWWTWRQ*KADPTEKIWRMLSLSPK QNWGSQDC*ILKTLMWINQMRNLL*PM*PSF*N IILTSTMQALMGKRMMKYFQVSHLLQILYKILRE KTE*FLRK*KFG*NNLREI*QEHRWWNQIYRIN ISHLSTSEFNMK*RGNRLNI*YNHYTETVNCHL TKHW*NNLGIE*PPGSLTGIYSLINLFLHLWAP* VPGCTERRWP*ERK*PFNRSTRKQQTRYNGNLS NIRICFKTRMPTKEHSMKSTGPGLLTGFQCHLI N*RTWPRGFILFPPHQSYT**KWNF*N*STVCSH CWFLQSQS*SLGSLSTGGESQWSSFYKTTCLL* KIASSLNNMR*HTRS*NRQLRCMSKQMVQWKKL RM**NS*MKPPLSGGISQ*K*GV*GACWKK*SLT GIAMAIQWLVCKPG*RMLKKCSINQKMPKRIFF EIYLIGFSSILP*TMLAIF*LKPVMRWFPVT*S SNYCC*MGGGGSCLWKSSNMLKLMRWTE*RRNTQ TVLLPCLLLQRKPIRNFLNP*KSLL*MSSY*FK TWRILSRGCL*WMPNTR*LQRQHTSLPKKAPKK KEKKCLRPCQSSKSS*PRSKNVTPHSFMSLSSC* FRWRN*KSR*RPFMTHLGKSMKLSQFLSVRHNR VPFLNKNIRNC*LVKKTVRKP*HLLRKAVKVFK SL*P*ATC*SILIRRGYKDRLQIFMLLFRVW*RK LEIGRSMWKPTVA**RSLRSLEQSWRRYCGLLR RAWRKRGIQRSSCGDTLSFSVSWIRGCSMLS*K LVMNSPTSFQSRSSRGCRKLFESSTNNGRIFKEK PLIICFI*RLMWRRIGS*PL*KNAELSWIERPS *CPRKAVKR*LKSTGFSSVTKVLIISVRKGYSS SRNSV*NSQCGTQ*GTHLEPVT*LSKSSELPLTA PTGSSWKTQTSGRTTLADSLSSHLGYLQMRHN* RGSRVRPSILPTTERLNVPLKRSEMVLPKGVRP SAG*NPG*KF*QKFLLRMKPKSREMSWQNYPALS RLL*RCCQRLKRC*AILGTVSSTKK*SKILSKN *FLALKKSRNKLRRSWILKICLKHSSYFFITSK RQSGSQQRREMCSSRSRRRSREKGGCLTEATRSC GSWRAHWMAWSAAGRGRNAASRSH*ENGSDLKQ TKKQ**DTFFKQVPVMNAS*VLAVWKVYLQNWN KQRSFLNGQKVLQSRLRTL*RKLQRYRLGPKISS CFNSRPSQSKNKSKN*KTRLKKILKPWKW*KPS GIILAVILRLCPSG*LRKKKNSMPWKLRHLPWT CKSAKLRSQFRK*KVSSAAL*D*KKKPSLLLSLL PLENLLELKPS*HK*EDTGKSFESMHSVWKEQS WDIYLSSKSLKRTLERSSNLCLNLKINLLFQLK YVLQLQKHTKFFKNIWISARPWSH*AARSLPSQP VPGRL*TEIPVFRRLRLYSSNTRTS*GGRRRDR RRWRICWPTGRG*RKNYHPF*PG*SGVKLKPVP QKWTFLQTESKWKVNFS*YRHCKMKLYPRPHSIA NFCN*RNHCSQ*PPKMM*K**NYIWSSWMRDGE IYHRSLTKGLIFFSLWLLNTSNLMSCCFPFLSG LNCFSVNYKLPLRLA*WTIK*PLLGIRTTQQK*R AKRANCRVCRVT*QSWVLWAVLRTSTSCRERLR TASSCLRRPARLWRGGSLPCPIWQNSSRAMPLC PAFSAS*GKQWKQPTV*IRTSLI**KRTSMMLFK MLKH*NLLPSVWMAFFPKPNTI*KSGALSKGLP AEPRLISSVER*RGSRTFWEPSRVRQMLWQC*K KHSKTRKRSF*KALRTLKKGLTKSD*KNLPAKLF SRG*ECLIS*KMN*ILTSMNYVG*KTKPSKLPR KM*LLHLKLTGR*TA*RSPGMIPKD*FMKIRVS AVDLLT**ENIRT*NQLYLKS*KMPAV*L*PELP *KIRRILNGLFPSMKLPRTK*ITNRKTWITLPA KENTCYLS*RKFTVVISAW*KQTWRAPWTNGWM YQRNLKKTWIG*E*ACPFGMMYCQLEMRLRDGQT TAFHRWQKTSATWITTSELKNCLKNLSLKLKTK H*DWKNCIPKLMI*KN*LKI*KHRQTFSL*KQT *CRNWSMPKK*LK*QKEP*RISRLKVHKWRSLLM T*QHGSQKWKNR**TVPKMRLVKH*KKSRIYKK NFKVNKATSALPKKISIACAASTTQLSWRAWAV Q*LV**RNMKP*ASCAPKPRPACRNLWKNTSVSL CRNSKNGFWEQRQQQKNHQIAPVTAKF*KQSSM IFRTFWTQSVMGRANLMQ*LKKDKLCMHICLNK LSVAFKNKSQRPMKSFKHF*NNALKISRLFKTVL QNLEALKISTEN*TYGSMKWKKGSIRKTWERVN STFLRRKMKFIKLKCFWENCWLQESLLISFPRE GSF*VKKATVLGRRAACVPSSSQATRTYLE*PKR NSGAARWPFRSTKPWRKHCKACGSG*RPFRTDW PVQRALLGAKTPWRNGCHKYRIFS**KVKGKLS *IWPLARGNRP*EVATKKVRG*FRLS*RPLKKCG LTS*APPSTLKAL*SL*LANGMTM*RGKTSWSS GWNQWIKK*NIPYNHSQV*KRSSSCLTTSSPSC LRQKITREPFTV*LRSPGSSTKRQRMSLSRTQLK RS*KHSLMI**LLPRKK*GKWKRL*KII*CI*M RSTSSQIGSIQQRKNFTGGQICLEIHQPPRKSY QKLRS**IPERLVQAVSAEWSRWLPK*NRTQLPV GVSSCTRRCRPCVPTGSSGKTVYSKRRAVWRTW SARWPFRSRNSQAKWLNWSRPWNSSVPF*KPGL SS*PSWKARTRMRR*WNAGTKDKRYWMLCKKQSL EQRISSLS*MNFVDFPET*VPTVEKFLA*LKSI IVFVCKHPRAARIKNRFYSKDFERPSGISSSGW LMQKSLPPSVLIYLKI*VKFQLVFRKYRSFCQKV KMDSTS*T*CCLKGNF*VPC*PKRKRKGSRPKL QLQKKIGKIFIQISTKKNLL*RI*RSK*RTLK* VLSLSRTG*VKLRRWSMKAAIASMICQQRGGSSR SSSLSLRKYTATSLSSTG*KRKLSSCGKDKLPA RALGTECRSCLLSI*R*AI*QRRKCQDWIESLQ NTISSLLGLKNYKTG*RMRFTCWIHTATRHPTKV CWTAGRSSSRLYYQSNRKKRFR*K***PGENLS FRILLQKAFPLFSSSCRV*RICGHPFCLQGFVV KANSKELSPSGQVIRMAFDSSPVGWIVWKPT*MN QKGSMRSCGIKQRCSEKPSY*MKKC*VTAACWR PSKSKGLA*QNTMSPS*NSRIYRNDTEPSKRGP RKP*PSLKNLSACTKSIRET*RHLKFGWGKNKKS STSIQFLKVMPTLMRQHCVIFRSYRYTVQRGRP C*TQCCTPERM*SHQVSHRQRTGL*SLSGKTGR LTSTGCPRLELSSITW*TN*G*WSKSFSK*MNGS KQQRRKSGTKK*LHTEMKLRKWELELRRYWTRA T*TAEWVARPPS*LPDTRPCFSKCWNK*NSWRR RFRVWRNQNHPSVPILIGMALLIKTSRMWLPRLT K*IQ**WGRN*RRWRFCSKTWRKVTVC*NQPGR KERGLLNTWRKARQRG*ERRFMITWSS*RN*PA LSGKNT*RWKKVFI*QRNSQINAKH*HSG*QNTR KFYMFLKNPKWNYMRKKLSYLNTSHFNKRCCPM NHQ*SQ*ERRVKLFWNWCRTSL*RTK*INFKVI TRTCAA*ERQ*WKKLLVLKTV*TIFK*KVIL*LA NVQTTCKRNLNKTCMLICRAQRTATQRSAAQLR GCTRVWNTNFRSTSADKTPCSSARPGFLQSSRI *SQVLNHLLVGQKPLSRSNTSELCKSRQGPT*IS FAPCVTCQMLR*KPQQKTFNKQSKRLNKSLSRP RT*LRAGKRSST*SLSSGFTCKMLISNCRT*RG GTLSWS*TLHRTWFHKLRILLRNYRANRHP*TP* *KR*IS*QRRRNRLNTRK*II*MISGSICAVSL TTCACKGKRIFREQEITMTV*MLLKCS*KNLLQ NGITWPDLMQRVQLSTWKL*KS*HWHCRRESMLL KI*KIKSRK**SI*I*MTRS*SKNRRVI*SNVG FSLRTSLKGKSKCQSPTWRS*MWCSPDFRS*WS GQKSNNPTSPRPLSRALLQIWLRTFSWITWPSAV NWRPSRCS*NRL*RTQTGSWQILVSMSDRSSRR LSLMHKAT*IVSVT*WASEEST*TKPCPRKPSF SWQCSRPPAKFSNMSER*CSVNTSVCYQMM*ANK SKHVRVHKPASRLTKMKSLDFGPRVAN**RKSQ SRKRVKCWGSFRNCRVSMTVFYKSAVTGYKN*R RIWFLGSILRKILIKLATG*NKQILLHFLKST** MRVLSFIHNWLNTKTFLNNLQNMKIFYLRCREL GRPYYHR*MKSIIPTSVKS*MLCLDNLM*LLPW LKTSSIKSRKQFLLGRNMLP*LS*QPSL*VNLKP NS*G*AKFPPTWPLRRLFLCKMVAEPFWTRWRA LGRRWMN*TRKKKVFAAQVSLGSQTRCCTLSPY ITG*SDKQNRGLAY*KTPPVLTKNTRRCANSWRD N*SL*KRSSPK*MRKRCLQRRSSKCITPWQEVS RTQGLY*NE*PYILKILPHTLTPWLMRKPGIRS SPGKGS*NC*LLPLVRR*QNVRAEWCRV*TSRLR *VAPWTG*GE*RQSSVGRCT*TSTCRTSKRKSE KSKFIRKRSSPA*ES*MR*VTRKRRSSQRPRS* FLRI*NTASLSSQSWMETSRKPYAPDRLP*LKYI ASVKGIIRYFKQPMTGLRMPKNCYSWQAMA*TW RAQRKISKATWNFSVQRISSIVTWRSSTAW*PP WTHSSSQPAKKT*NRKWLLWNSGARG*AGTLVPK WISCRDAQLNGTITRKQGKRLLN**MIQKRNCL SFLC*RLRLVMKRKKNCQNTRL*CQWLTLSMRK LWPLRKKLHNWRKPEMMPAKPP*AGQ*PPSGSAG HAFELWPRTRRRSWKMQWMSGRALTTRLKRPLK *LISCKISYLEVQQRKHRKQSS*LFLNTTTRSF WSWSSSSRPWACCGSKP*ACSRMEPPQPLGKSLR SCRKSPPCKIGA*TCRRK*RLMESW*SKS*RTE KWWRLRSIL*NVGFRKRKNI*GIQQ*K*MLNLK NFRFS*QKPQITDRTLKKWQKNRRRST*VFIPYY LLNSPFSWLKWR*I*RSEIRSKTK*KKLSRARP RARNSAGKFRS*LKTSQLF*LS*KRRQIM*FKL KLTKRCWERN*MAVIQS*WN*MQQYRNSWNRMAN WVSHWPRR*EN*LNFTSRPLDKLRIGSPSSIRQ HHI*KNTMKCLN*F*SGLKKLKSWLMELLHGIL QASFGNNIFCIRPC*KNPKKLTVSWKQ*LRNYST SLACTVQKKCLSKWQNWDGRLRSCDR*SKFVCR TSKMQLRI*KNLKQS*KSYKLPWSKPRQH*LLQ KLDVSVSRSSSLIGSICCLRWSH*SRRCKQCSSA RVPSGSPRMWLPAYLSVMLLCGCRKRPAGCSTP PSSSVTSCRQLWYNMNNMSKK*NISSN**KELT ERLRINLLPPVTYRSCRLRFLGMRSWRRKLRATR SRSLL*IPSARC*R*KPSTPPCC*R*PRSRGWR KGQRTWMGSSSPRLRPTPLWS**LQVAVTLCCH RSLRSLGRREPTVRFPLHLPVAPLHLWLIQMLLL TRTLHITKPCLLRGCRQMLQKFTPAHPHPRSSM NRDWSHPLLPNWVICSVLGKP*RM*SVRSSAHS MKLWNASRSTRTPSSPSLRRWRPLS*NSVRAQSL AGVQKARWLNIRH*WMRFSCSRMKSMSSSPLSQ RSWYPSLVRPTLRSSWPCSPRSLS*PSECPPSG *KPRGNGSFWRRS*MISWRNKGRNRPCRGIAVKP MSWTAGS*VPRPLWTLR*VHPRSPWTWRPSLWT ARICWWK*SRRWWLYQNCQSTMRTCCWRAKLTP RTRPSSWLES*EGSRGACWSCREPCMISSSTCRE QHRRRRRAMLT*QPRRAPASRNGWPKLAPHGPS SGRAVSSNKKS*NRN*PSRRVSFAQ*PVVERRF *FNIRRQRPLVMLAKNLMCYPRSWGWKGRNHPLK TR*E*NGKAYIKNLVPSRNYYRMFWNRNKSKCF IAGQIDSCLVCHCTKGTCQPKINLQLHLCWMD* TKPSRRFHPRVEGQRGRVYTWSRSCMMESQPPLL GWMTLKNVYLLPQHFYQKKQRLVSSTKRFLPKT LRKCLKKWIRTKTCFPKLFQRMVIIEMLLKILW VVFWAGYPC*TQ**INDVIR*KKDFSKY*ISRMI *KCCLHHWLTTNTSFCKNWQMCLNSP*QNK*RQ YNRLKMDSKNLMQESLN*RGVVTSYRSSSRPCK NSPSSRTCMMS***SLAPGGVV*IRTLHSRVSMR GPYKIWLTC*KLVRRRWQETRKSSCLPKRKSSN YLTNIRNTFRAWNLI*S*LKHSSER*SALQSKR KPSSIQS*WLRLLLY*NGLTRGVWSWSTF*RRGP IWMRTSRSSADSWRWWKAASQAWVWWRRTRTGL LTA*HSTSI*NLALMNTSPNYIKY*MMGNDF*Y PSAAQI*KAN*INLESAG*VTPIKCLRNFTDWKQ Y*NTGPDIKVNLQI*FTGYNLQKTG*NFGLSNL *QSHKSWKWSVII*MLSWSFLKKWMPNLP*NHL F*VLEISSFD*KRWTQPRCALSCRALIASGLTC* PISQPSRRSSTSSRWINCLPAMPFLKS*VGFL* WKMLFRRMKIILKIP*VTRQFMNTFRNIRVLR* TLTVNS*QWIL*TSPCYKSAVRMWKVSVVIRLIL LSNLEQ*IKVGKFCKV**LRRSSCWKAYWNLGQ NMKIMYNV*KHGLKPRKRD*NNSIELEIRLLFK MH*KTVRIWKI*LKQKKKK*RKLSRMDLL*FRTR KKTSLALS*AHCESSAKPGQI*ITWLDN*RYC* NQCLTNGVVTKWPLTR*TVTSWRPDTLFPDSVC *LAP*KLCKFRWTIFRISKMIWKNRKGAYRNLAL SPTNY*KSVTHP*QKLLPIH*KKST*DGITCWK RLLSSYSPARPYFSFGKDTRTTPNSVLRQFSSR RIEPMSC*RQPQTRTLPMMRLPHGFKIATTSSKD WAQLKIPSFFSMSWESN*SNKWMLPQHQLFNRI NSL*VNTCVPWSKLSANSRLHYRLEFLIMKPLP RV*KLWRPG*WKLKKYYKGRTLATHLTSPQSRKG WKNLRDRC*NSAAWLQI*TV*MSLDIGYP*MIR KSKECRI*TAIGL*SPLRLQKDSASCSHFCYNI RLSWKNVKHGWNS*FRQNKS*Q*RFQEIISTFWN SREHTSCFKPRCSVVSRFCTQSLLMGNVF*NKV KLMTGMNST*N*HSSVINGRE*FAGPSRGGGSL TARFASGSAIGRWQKSFVNGWLKCPTSP*VVSEV FLYHCNKQGPSLMKCSSKKKCFCGNKAATS*LW RLASNSFSRRTVALRPPCRPNSLKSKRNGNQPA CGWKNRRKN*PSC*KTGKNVRKE*QIPWRNYELS KRSFRSLSRITMKSSMQNKCVARN*KMQLGAGQ MT*PS*AC*RTPSLPISVLMISPFLMNA*SFCK GSGKNYATSSP*GGSK*VKD*MNGQSSVKRTRNS VSG*LKWKAKFLRMETFSLKK**RSSRRIIKRK LLLLKRTKYSSNKWENDLLKPAMKAKHLRLNTS WERSTTGGSISWTSLQPG*RS*RRPW*PCSSLIR T*AA*GPGSLTSSQSWPSQ*STIPVTRKKYRES LMSSRSFRET*RSTVQVLHLSSTCVKSCCTTVT PVPLMPSVTLYSRLRETWTGGGETFVLCPWKGG* KSKRRGDCGRNFWMTIHVLKIG*SLQKGQLLFP ALLG*SIQLPRKN*RNLRLSSDRSTSA*RSWN* STSSTAAWPGRTALIQHVASNRWFTKATRDGTTC KSVSPPSCADSSILLASVRSLRLRGTAFWSGSQ RWICSSLILNIFLSVMFKLK*SNSRPSSRKFH* TTIRLSR*LPKENS**KRVSPWMQRSSRRN*MSS DGTARRSSGVWKDTIRN*SACLSQTMSTTSQTG SWSWKTLQLCRTCTGTTALQTACFLHSLPPISP SRSLSPSGASGQDETPRLVWTPSPWSGITTMTSV GTWSLQCPELCPLRMKKVRMTKISTSGELLAYQ M**SPKALRPM*NSQKMQSKIPPGTTVP*SHRS DNWAKPWMIAVFRYSKPKISFAAKLPRGRS*TPA TKAT*NCWANAVAV*TP*RDWSTN*RRKRRAFL ALLTCIVPKPKRLV*LTDGSFSRPRH*ARS*G* SRTSRSGSSLTQT*TASGPGWGTRRRSWNSSSVW NSALTSRPSSSRSKSSRSSRKLWTTAKPSSSPS ISAALSSPRLTARRAGTCRIACRR*MGAGTECA LCWRSGGACCRMP*CSARVSMK*AMVCFLCWRTL TEGKMKLSLLILTLMQRYFRTITNSLCK*SMSC WNPNSE*PLCKTCLANYW*MLKEQTV*KPKKKS MLLEIGSNFS*RRSVVISRNWRSY*TCQVVSRIC LPGLLLMNWTPQGL*VPHQEGAPQTDRKRHEAS VVSHSLDPLSAVHIAGPQKVAPIPPFLSQGQVG PAAASCSESSEQLFPFSFSCSSSSGLPALYQCQR KTTAVPSPTTLPGHSTPCSDTRMALLHSELSRC HLQKCW*HKEDRVISNPKLPTRGP*SWRKPSVW QL*PSSRSHVCKLWLQRWKINSDGGTNRQQEGLE EIWFETLNLSTKEIE*GPPKFPGLMNSGPLAHS VHSQGLQ*TIWAAFPWCCSNHQINDPPKHHVSV VQSTNQPVLKRF*NLVTYNF*ELIWQLPFYLVFL WGMMF*PLL*KHKL*I*KALFFRGIKKN*M**I RSWKALCEKS*ML**KKKDIYVCTVC*SQVLFV LISLHLL*IL*N

Frame 1

GRRPQRAEIVVLCHQGGWAPAVLQTAPDPGDRA GGQPRIPGVPPSLGAESREEAFARFALLLGN*T RPREKVLEFM*EDSLKTEEEKEAVQSLGELPPC* VLQRPGIHL*QNRSRKVQACFLEWCSPVLPPVK SLLVLASCFRRDHGNLQRGLPVSSGYRQCDAEA AR*ARDSTKTNFHKMDQLSSGQAETSNGGGRSF* RHERWC*TACPSGGPVWAETAL*TRTPDEANPC CG*HWHGTQVPRRKKVHAQRITD*ISQH*LHRY S*WPTLNSSWIDVDHYSIFPD*RVDQQPAPAPVF VQQRILRGQHS*L*DSQPTK*TEGDHQDPRKC* EGFIKVGSVHSWQADWNRSKRFWEELEKRGCLS FSYSCHSTGIGGLGDSERQIQPRKFGGCFHYRRN RTGDPKTARS*RR*CG*TR*EIYYDLCSPVSET LS*HPQCKH*WARG**NTSRFPIFCKFCTKF*E RRQSNF*GNESLDRTI*ERFDKSTDGGIKFTG*I SVI*ALQSSI*NEEETD*TFNTTITQRR*IVT* PSIGKTILG*SDLQAL*LAYTA**ISSCTSGHH RCLAVQSGGGPERGNNRSTGPRGNSKHDTTET*A T*GSASKHGCPQKSIP*NLPDQVC*RDSSAT*S IRGHGREVSFCFLHIRATPNENGIFRIKVPSAL TAGSCRVKAEVLDH*VREERVSGAASTKLRVFYR K*QVL*TI*GDIPDLETDS*DVCQSRWFSGRS* ECDEIHE*NHRSVEESLSRSEECEEHAGRSDL* LGSLWQYSG*SASLARGC*KNAQSIRKCQKGFFS KFTSLDSAAYCHERCWQFSN*NL**DGFP*PEA AITVAKWAVEGVVYGSQAICSS**DGQNEEGIH RLCCYPVCFCNGSP*ETF*TLRSLFYECQAINSR LGGY*AEGACDGCPIQDNYKDSTPHYQRKPPRR RKRNVCDHVKAQRAANQGQRMLLPTPL*VSAAV DSVGGIRKADDVLL*LTWENQ*NYHSS*A*GTIE CPF*TKTSGTVSLSRKL*ENLDTY*ERQSKCSK VCDLEQRVKAF*SDEATKTDCRYSCCFSEYGKE NWRLEEACGNQQSLDEEV*GVSSRVGEGTADCSG GPGGKGGSRGAPAETH*VFQSAGSEGAQCFPES L**THRHPSRAGAAGAAGSCSKAPQTMEGSSRR SPLSFASSED*CGEE*VLSLCRRMQN*AGSRDQA DAPGRQ*KDN*RAQGFLQ*QRSSSSL*EKVTAH RGTLCETPSAGPSKGHTWNLSRDSQRAQSCH*Q HLQEAHGRPRQVEGLH*QIL*VLILDIYK*DTIK GDQG*GHRYCQPRRG*TCR*RDQKWCYQKG*DP QLAEIQAESFDRSFF*E*SPKAGR*AGKIIQLF QGSCDAAVRG*KDAKQFWGLCPVQRNSQKFSRRI NFWL*RSPGTS*EDLGY*KSV*STAVTSSSPAK DKADLSKEERCAAADRAGAAGRRGAA*PRPRGA AEAGEHTGWPGAQPGEAGTPHPGHIKKMGAI*NK QRNSSKIPFSNRFQS*TLLEF*QFGKFIFRTGT NKGVF*TDRKYCSPG*EPCKGSFRDTAWAPK*A AASTAGQVNQRTSQKIRRHA*RRY*NHGNGENQV GSFWQ*F*DSVRLDN*ERKRTQCLGNFVICHGH ANQPN*GHNSGNRK*AQQHCRIRRRSPVFCSVC YHWRICSN*SQVDTNKKIRGRASRACTVSGRNNP GTFISAAKV*REP*KDPAICV*I*R*TCCSN*N MFFSYRNIQSSSRTYGSLPGPGVTEQRDHCLLS QCQEGCEQRFLCSGGCGSTAAIRGHPKEGEGETD GAGESAGPLAEARERTIILFDLVRAG*S*SQFP RNGHFCRQSQSGR*TSVNTGTAK*SCIPGLIL* QTFAIEGIIVLSSLQR*CENDETTFGAVG*EMER FTTDH*QKD*FSSVCGC*TPAI**AAAFLFCLD *TVSQ*ITNYL*D*HNGPSSSPYSA*GPRSRSR EQKGRIAESAGSLSKVGFSGPC*GPPPPAGKG*G LLPAV*GGQPGCGEAAACPVPFGRIPPEPCLSV RHSPPAEANSGSNQQYE*ERV*FDRKGPQ*CSS KC*SIRICCRQSGWHSFQSPIPSENREL*AKDFL QSHG*SALWRGREDPEPSGNQAE*GRCSGSVEK SIPRPERGASEKH*GH*RKD*QRAIERTYPPSS SAEVKSV*SARR*IEFSRA*TMLVERQSQANCPE RCSFCT*S*QGDKPLRGHLG*YQKTNS*KSGSV LWTY*LNERISEPEISCI*SLRKCQQCDCNQNY HKRSGGS*MGFFQA*NCQEQNELQTERLG*LYQQ RKTLVI*AEENSQ**FQLGENRHGEHRGQMAGC IRET*RKHG*AESKPVHLG*CTVN*R*D*GMVK QLRSTDGRKHQQPG*PPQS*RTA*RI*V*S*KQS IEIGRTAFQS**SERIN*KSRNTARPSVYRSRL NAETGACQRNN*SSKRNPEGFHGSKYTSGEVY* *HNNMVHKSGRIVDELCPK*DL*SIEKSQGYTKR TSKSTKQHQLYPRKSQ*LVPQVPLS*VGEPGPC NDWSDKET*SREPVVLQNPGQPAGISGKTLQ*V YAGIPRMVFGSKGSSKRIIRSHR*QQSSRSKAP* SSEHFGLSQ*WAEQT*CSDSRRTNFVCTFV*TN CQ*HSRTNHKGQ*RVSSISETMP*R*AGSSRLC FRTWKL*RSAQKTELMDP*NGRKVQYGKLGRE*T AHS*EEK*SS*S*NVFGRTAGCKRVS**AFPER AASE*RRPRCWAGGPPVFPAPHKPPEPT*NDQR ETPELPGGPSGARSPGGSTAKHVVLGEGHSGQTG LCREHSWEQRHPGETAVTNTGYSPDER*RGS*V EYGHWQGGTGLEK*QQRRSEGDSDSVRDP*RSV G*HHELLRPRSKHFRVCD*PME*LCREEKPVGAV DGISGSKNRTSLTTTARSEREVRPA*PPPVHPV *GRRSHESPSPSNCEVQGALRKDRG*VFQGHSS RGAENTV**YNDCCQGKNEESGRDCERSSNVFRC GPRVHRLAPFSKGRTSPVVRYVWRFISHPEKVI KN*GADRFQRDWCKPSQQSGVAGSRSETEHNCQ WV*AHAHGDAGPACRLEAVGRQCIPNAELFGEPG QPDGPFGAGILRPSGSTGAGPGTVQCPSENLGS AVNPPGRQEHG*GDSGMLAQRTRDTGCFAKSRA *NRGSQVSAE*TLSIFQRPEYLQWKSFWLD*RV* LSLFASIQGLPE*RTDFTAKISKGLQGFPAVVG *CKNHYRQVF*YTSKYK*SFN*SSENTGVFVRK *KWTAQAKHDAV*RGTSEYPADQRESERDPGQSY SCKRRLEKFSFKSPPKRICSRESKDPNEGL*SK C*AYPGLAE*N*EDGP*KQQSPL*SASKEEGAA EAPVCP*GNTLLRASAQQAERESSAAVGRTSCQQ EL*AQSVAAVFSVSSAKQFNKGESVKTG*NRCR TQSVLSWD*RITRLDDGCDSHAGFILPPDIRQK CAGQQDAQARGSIISQTGKRDSDENDSDQGRICP SEYFSRRHSHYSAAAAECEGYVGIPFVCRDSL* KPTRRSSLQVDKLSGWRSTVLRLDG*YGSQPE* IRKAACGAAG*NNDARKSQVIK*RSAELQQLAGD HRSQRGWHDRTLCHPARTPGSTGTIQSHPREGQ GSRNQV*KTCPPAPRVSERPKGI*SLVGARTRK ARPVFSS*R*CPHS*DNIA*SSGATGTLCRGAGP VELSAAHQRGCDPIRYPTGRGPGFRVSPARLAG LPAQAVRDSNSVQ*RGEQIEANGAKVSASR*MA QNSRGEKVARRSDCIQR*S*GSGS*SSGDTGREP REQQNGLPGHPADFQIPGPASPSAGTNKIPGGG DSEFGGIRIIPQFLF*LVWLYS*KLQECGYQD* QSRYSNDGEEIEDVGGFAQRHGERSQFAEISPGE RREGC*ILGGRRGREVKKGDS*SHGAVEGTDQH CPERTHDAGKRSSFSKGILR*MQSTDTVDSRIP GNSTCS*RTQNGII*EKSSVI*IQVTSTNGAVP* TISKVSEREG*SSFGTGAGRHFKGQNRSTSK*L PGPVQHRKGNDGRNCWF*RPFEQSSNER*YFDW PMCRPPASET*TKRACSSAGHKGQLLSDLQHSSE DVPEFGTRTSEARQPTRHPAAVPGLAFCSPAGF RAKSSTTS**GRSH*AGQTLQSFARAGKDLPRS PLLHV*PVKCFGENHSKRHSTNRAND*TKACPGP ELNSGLGRDQAPEV*ALDLPARC*SATAEHEEE AL*AGAEHCTEHGFTS*GFC*ETTEQTGIREHH NRKGE*VNKEGGIA*TQGNKSFK*SVARFVPSV* QPVLAKGRGSSENKRLP*LYECC*SVPRKIYYR MG*LGQI*CREYSCPPGSFEKVSIGIAGEKVCY *RSERSKAENDRASEFR*QGVSQRTDESFRATLV SA*GPH*KENPSVSHQLGGVKCGAVQISGANGV GRRATTQHRRGP*AEPSSRYGSEPSHGSPGHLQ *TGGQADAPEIAYKGRRQGHGRSWSQ*ATGHPEG SL*CTKPRELSQ*LSGPAKKVLKQSLVRENPVS HGSVPGHQPNSAT*AKDNVP*THLSVTR*CEQT SQNM*ECTSQPQDLPK*SHWTLGPGSRTNEGSHR AGKE*SAGEASGIAECL*QCFTKVQSPVTRTRE EFGF*EAF*GRF**SLPLAKTSRYCYIS*NQPN E*EF*ASYTTG*IPKHS*TISRI*KSSTYAAENW ADHITIAE*SRSFLPQ*KAKCFASTI*CNCCLG *RQVL*SPGSNSCSEGICFLD*VDNPVSE*T*S PILEDEQSSHRPGR*GGSFSARWLQSHSGRGGGP WGGGG*TEPEKRRFSQHRSALAARQDAAPCHLI SQAEATNRTEG*LIRRHHQCLPRTREDVPTAGE TTEVCKRGAVQSE*GNAACRGEAQNVSLPGRKSP GLRDCTETSNHTS*RSCPTP*PLGL*ESQASDP VLARGVKTVDFCHW*DGDRM*EPNGAEYRLPD* DESLPGLAEESEGRAQWAGVPRPQPAGHPRGNQK NPNSSGRGPVQLENHECAESQGKGEVHKGQGAD FCGFRTQPR*ALRAGWRHPGSLTHQTGYLD*NI *PVSKVLSGISSSQ*LA*GCPRIVTAGRQWPRRG ERRGKSQKPHGIFQYRGSVP**PGGAPQPGSHP GPTHQANRQRRPRTESGFSGTQEPEDEPGLWCP SGSLAEMHSSMARLPESKGRGY*IDE*YRKEIV* VFFVEDFV*S*SGRKIVRTQGFSVSG*LFP*EN CGP*GKSFTTGENRK*CQQSHPEQVNDHRLAAL DTPSSCGPGPGEDPGRCSG*VDGL*QQG*KGH*N D*SAAR*VTWKFSRESIESRALNSS*IPRHVRS GAGAAAVGLGHAAAANPEHAPGWSRPNPWGRAS AHAGNHRHARSVPEHAGESED*WKVGEARAEGPR NGGDSDQFCEMLGSGNERIFRESNNRNRCST*R TSDSPNRSHKSPTEH*KNGRRTEGEVLRSLYHI TF*TLPSVG*SGVRSKDPRSDPRQNKRS*AEQGH EPGTQPANSEVS*RPHNYSN*AESEDR*CSSS* N*PKGAGRGIRWL*FKVNGIRCSSTEILGTEWP TG*ATGQEDRKTD*TSPADH*TS*ESALQAQSGS ITFRRIQ*NA*INFEVD*KS*SLGSWNYCMEFC KPASGTIYFASDPARRIQRN*Q*AGSND*EITV PH*RVLYRKNVSASGRTGTGD*GVATDDQNSFAE PPRCS*GYEKI*SRVEKVTSCLGASPGNTDFSR SWTSQSQGAALSSAAFVV*DGVTEAEGASSAAL PECPPDPRGCGCQLTSLSCCSAAAGRGQPAAAHR HPAV*HHAGSCGTI*TI*ARNETSPATDRRSSQ RD*G*TCCHQ*HTGAAGSDFSA*GAGAEN*GLP GADRFFEFQVQDADDESQARHHAADGDRGRGAGG RDRGPGWGAPPHAFGPPLCGHDDCRSLSHFAVT GH*GVWGGGNQQ*DFLSTCLSLPFTCG*YRCFC *PGHCILPSLVC*EVADRCCKNSPQHIRIPGVL* TGIGAIRYCQTG*FAAFLGNLKECDQ*EAAHTL *SFGTPAEVPGLPPVHLYEDGGH*AETQ*EPRA WQESRKPDG*TSGIDG*DSHAPG*NQ*APVLSRR GAGIRVL*GRPCGAAGLAVHAHCLSRANVHHQD ESLGETAAFGGEVE*SAGGTKAGTGPAEVSL*S R*AGQLALEYQGHSGHCAESTQGAHGHGGPAYGL PEYAGGNRAEGGGFIRTVSPQ*EPAAGGQSSHQ GRGRAAGWKAEKAQGEPAGAAESPA**AAQHAG NSTGEGGERC*PNSHAEPRRPGMAGPSSHHMDPA AAEQSPATKRVRTGISRAEESPSLSSQSWRGDS NSTFGGRDLW*CWRKT*CVIPGVGDGRGEIIR* RPDENEMGKPTSRI*YQAETTTECSGTGTRASAL *QAKSTLVWCATVQRGRANPR*ICSYIFAGWTE PSLRGGFIPEWRGKEAEYTLGAEVV*WSLSHLY LVG*R*RTFICCHSTFTRRNRDLSLQPRDSCQRH *GNV*RNG*EQKLVFPSFSREW**SRCY*RYFG LSFGQVILARLSSESTMSSDERKTSANTKFPE* SESAVYITG*QQIHHSAKTGKCV*TARSRTNRGN TTG*RWTQRI*CRNH*IKEAW*QATGRAAVHAR TLQAPGHV**ADDDHWLPEEWSESEPYTQESV* EGPTRSG*PARNWSGEDGRRPENHRVFQRGNPAT T*QT*GILSGPGISYDLD*NTLQKDNQLCSPKG NPVPYRADGSGFCCTETGSQEGCGAGVHSRDVV PSG*GPAGAQQTAGGGGKQHPKRGSGGGERGQAY *PHNTLPAFKI*P**IPAQIISSIR*WETTSDI HQLLRSRKPTKSTWRVLAK*HQ*NV*GTSQTGN NIETLDQISK*ICRSNSLVTICKRPARILDSAIC DSPTRAGNGP*SSKCFPGVF*RSGCPIFPEIIC SEYWKSAPSTKKGGHSHAAL*AVAH**PVD*PA NQYPSRPGEAPPAPDG*TAFPPCHF*SHELDFSN GKCYSEG*R*Y*KFHRLQGNS*IPSEI*GF*DR H*L*TADSGFCEPVRATNQQSGCGK*A***D*F C*ATWSNE*KLANSARSSN*EDPAVGRLIGILVR I*K*CTMSENMV*NPGKETKTTASNWRSGFCSK CTERLSGSGRFD*SKRKRSREN*AEWTCFDSEQ ERRRL*HCHEHTARARPNLGKFRSHGWTIKDTAE ISA*PME*SQSGL*QDKQLPHGGQILSFPIPSA DWLLRSCASSGGQSSESPR*SGKTGKELTEIWL YHQPIIKRVSPTRDRNSYQYTERSQHEME*LAGR DC*AATVQQGPTSALAKIQGLLQTVCFDSSAAG GSNQ*AVEGSHKQGHCR**GCHMDSRLQRPPQR TGHS*RFPLFSP*AGRATEATSGCFRSISYSIGS TLFESTLVCPGASSLQTADFITGWSS*L*NLCQ EFRSFGGLDSGS*RNTTRAGP*PLI*PLHNPGK DGRT*GTDVKIQQHGSRFRPSK*AWI*VTLE**G NQKNAESEPPLVSDLLSDYRKIQQVAVIFATTS DFLGKM*NMDGIPSSDRTKVSSRDFRKLSAPFG TAESTRVVSSRDVQSSADFALNHY*WATSSRTRS S**QG*IQPEIDTPQ*SMAGSDSQGPAEAGDH* QPDSPVAAL*GDGRKAS*MVG*SVLPPHEWSRK CSYTTATSKDPL**SAVQRKSVSAATRQLHPDCG GWQATPSLGGQWR*GRLAGRTR*NPREMEISQH AAGRTEEKTSLLVERLGKM*ERNSRFPGETTNF QKEAFAVSPGSP*RAPCRTNALQGIRKCSWELDR *LDPVEPAEGHPLCLYQC**YLHS**TRRASAK AVGRTMPPALLKAAANR*KIE*MGSLQ*KEQGT L*VVDSNGKQSFSEWRHSH*RNDREAQEGLSRGN CYCSREQNTAPTNGRTTC*SQP*KQSI*D*IQA GKGQRPVAASPGPHCSQGEEAEGDPGSRAAA** EHEQPEDLARSHRVRAGQANSLRFL*LGRNTEKA **AAGASERHREAQYRCCICPQPV*SPAARL*R LCH*CRV*LYTAGYEKPGPAVEKHLCYVHGKEA ENRRDVAIVAEISG*LFTF*RLAEVFRKDSCFSQ LFWGDLYSCQGRTKEI*GFPATGPRVPDAAGTD QQAVPPPGQGEPH*FSM*PQTDGSRRQPEMGQP AKACHLHLAQTQAFYWPA*GV*DCAGQHSGLAHR DGSAAH*Y*TFF*V*CSS*NKATQGLPAGNFTE PQ*D*ADNCPRRTADRKE*ALGCSDHRGGTR*A PTVLPGGLRACGKIP*ETDPPASPRR*ARPLRQG AGAGRLCSSVGPALARPLCRQPAFSTAFLQSLP LARSAPPERAVRTRHPG*CGLHPPGVGSRL*PQ SGPGVCNVQSSAL*G*RRSG*QRFLPPGSCWLIR CNDPRKP*GLCKTHRKCNQKYLRGPQCPRVTDP TTGQSPG**PFSDTANRKYHSQQNSHGAGARHQ LQRLHETAGRMQ*QYRLREETGAQTEGGRGEPSW LC*PA*YRNPNGWCD*PMGASPGPGIEQGVEDE AEPPEVAAV*LRLEQHLGLAGGHGGGVGTAPAS GTQH*HPDHRAPDQKAQGAPESCGPPQSHHPLHQ SLQP*VHPG*QQGEPGPAGSLVADEWALGPSVL SAGGVAGPAAGCPDAVPGFP*NEPWFASYAGEH *QKEK*NCPY*F*P*CRDTSGPSQTAYANKA*AV GIPTQSSLFARHVLPTTGEC*RNRLFRSQRKSP CYWKSAQTSLEGGQSSYQGTGEVIRRVK*SAGF VFLVFC**TGHLRVCESHIRKEHPKQTENATRQV *SLTAWTLCQQST*QVHKRWLRFLPF*ARARSV RPRLPVQSPPSSSSPSASPAPPHRACLPCTNVR GRLQLCPLQQLCPVIPPHAQIHEWPSSTLN*ADA ICRSAGSIRRIGS*AIPNYQQEDLDLGESPRCG SFSPPPDHMCANYGFRGGR*TVTGEQTDNKKVW KKSGLRL*TLALRRLSKDLQSSPDS*ILGPWPIL CTAKDFSRPSGQLSHGAAPTIR*MTLPSTMSVS YNLPTNQC*RDFRTL*HTIFKSLYGSFLFTLFS FGA*CFNLCFRSTSCKSKRHFFLEV*RKTRCNK* DHGRLYVKKVECYSKKKKIFMYVQFAKAKFCLY *FLCIYYRYYK

Frame 2

AAGRSGLRLLSSVTRAAGLPQSCRPRPIPATGR ADSRASPGSRRAWAQRAGRKRSLASPCCWETER GRERRFLSSCKRTVLKRKKKKKQFSLWESCLLV ECCKGLEFIYDRIDLEKSKHVF*SGVALCCLQ*R VSWCWLRASGGTMATSRGASRCPRDIANVMQRL QDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLF EDMKDGVKLLALLEVLSGQKLPCEQGRRMKRIHA VANIGTALKFLEGRKSMHRGSPIKLVNINSTDI ADGRPSIVLGLMWTIILYFQIEELTSNLPQLQS LSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAK KALLKWVQYTAGKQTGIEVKDFGKSWRSGVAFH SVIHAIRPELVDLETVKGRSNRENLEDAFTIAE TELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKH YPDIHNASTDGQEDDEILPGFPSFANSVQNFKR EDRVIFKEMKVWIEQFERDLTRAQMVESNLQDK YQSFKHFRVQYEMKRKQIEHLIQPLHRDGKLSLD QALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTI GAWLYRAEVALREEITVQQVHEETANTIQRKLE QHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQ LEDMAERFHFVSSTSELHLMKMEFLELKYRLLS LLVLAESKLKSWIIKYGRRESVEQLLQNYVSFI ENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAE NVMKFMNETTAQWRNLSVEVRSVRSMLEEVISN WDRYGNTVASLQAWLEDAEKMLNQSENAKKDFF RNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQ QLLLLNGRWRELFMEVKQYAQADEMDRMKKEYT DCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQ DLEDIEQRVPVMDAQYKIITKTAHLITKESPQEE GKEMFATMSKLKEQLTKVKECYSPLLYESQQLL IPLEELEKQMTSFYDSLGKINEIITVLEREAQS SALFKQKHQELLACQENCKKTLTLIEKGSQSVQK FVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKK TGDWKKHVETNSRLMKKFEESRAELEKVLRIAQ EGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKA CDELTDILPEQEQQGLQEAVRKLHKQWKDLQGE APYHLLHLKIDVEKNRFLASVEECRTELDRETK LMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLI EELCVKLPVRDPVRDTPGTCHVTLKELRAAIDS TYRKLMEDPDKWKDYTSRFSEFSSWISTNETQL KGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETL SWLKSRLKVLTEVSSENEAQKQGDELAKLSSSF KALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEE LISGSKEVQEQAEKILDTENLFEAQQLLLHHQQK TKRISAKKRDVQQQIAQAQQGEGGLPDRGHEEL RKLESTLDGLERSRERQERRIQVTLRKWERFET NKETVVRYLFQTGSSHERFLSFSSLESLSSELEQ TKEFSKRTESIAVQAENLVKEASEIPLGPQNKQ LLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTK WDHFGSNFETLSVWITEKEKELNALETSSSAMDM QISQIKVTIQEIESKLSSIVGLEEEAQSFAQFV TTGESARIKAKLTQIRRYGEELREHAQCLEGTI LGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKI CSSATETYKVLQEHMDLCQALESLSSAITAFSA SARKVVNRDSCVQEAAALQQQYEDILRRAKERQ TALENLLAHWQRLEKELSSFLTWLERGEAKASSP EMDISADRVKVEGELQLIQALQNEVVSQASFYS KLLQLKESLFSVASKDDVKMMKLHLEQLDERWR DLPQIINKRINFLQSVVAEHQQFDELLLSFSVWI KLFLSELQTTSEISIMDHQVALTRHKDHAAEVE SKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAE DCFQLFEEASQVVERRQLALSHLAEFLQSHASLS GILRQLRQTVEATNSMNKNESDLIEKDLNDALQ NAKALESAAVSLDGILSKAQYHLKIGSSEQRTS CRATADQLCGEVERIQNLLGTKQSEADALAVLKK AFQDQKEELLKSIEDIEERTDKERLKEPTRQAL QQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQ KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQC CGLIDLMREYQNLKSAVSKVLENASSVIVTRTT IKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTS KGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDV SEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSN NCVPQMAENISNLDNHLRAEELLKEFESEVKNK ALRLEELHSKVNDLKELTKNLETPPDLQFIEADL MQKLEHAKEITEVAKGTLKDFTAQSTQVEKFIN DITTWFTKVEESLMNCAQNETCEALKKVKDIQK ELQSQQSNISSTQENLNSLCRKYHSAELESLGRA MTGLIKKHEAVSQLCSKTQASLQESLEKHFSES MQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLH DLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQI VSSIQEQITKANEEFQAFLKQCLKDKQALQDCA SELGSFEDQHRKLNLWIHEMEERFNTENLGESK QHIPEKKNEVHKVEMFLGELLAARESLDKLSQRG QLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKE KLRSCQVALQEHEALEEALQSMWFWVKAIQDRL ACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKL NMAIGKGEQALRSSNKEGQRVIQTQLETLKEVW ADIMSSSVHAQSTLESVISQWNDYVERKNQLEQ WMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILS EAEDHTRALHRLIAKSRELYEKTEDESFKDTAQ EELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLD AVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS KIKELIDSREIGASRLSRVESLAPEVKQNTTAS GCELMHTEMQALRADWKQWEDSVFQTQSCLENL VSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQ QLTLLEGKNTDEEIVECWHKGQEILDALQKAEP RTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEY NCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLV NAKITTAKCFDIPQNISEVSTSLQKIQEFLSES ENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKV TAAKEDWKNFHSNLHQKESALENLKIQMKDFEVS AEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQ KLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAAS KSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAE HNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKS VLDSRTLKLEALLSVKQEKEIQMKMIVTRGESV LQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCK SQLEGALSKWTSYQDGVRQFSGWMDSMEANLNE SERQHAELRDKTTMLGKAKLLNEEVLSYSSLLE TIEVKGAGMTEHYVTQLELQDLQERYRAIQERAK EAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEK LDQYSVLEGDAHTHETTLRDLQELQVHCAEGQA LLNSVLHTREDVIPSGIPQAEDRALESLRQDWQA YQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWL KTAEEKKWHEEVTAYRDEVEEVGARAQEILDES HVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEE IQSLEESESSLSSYSDWYGSTHKNFKNVATKID KVDTVMMGKKLKTLEVLLKDMEKGHSLLKSARE KGERAVKYLEEGEAERLRKEIHDHMEQLKELTST VRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQ EILHVPEEPKMELYEKKAQLSKYKSLQQTVLSH EPSVKSVREKGEALLELVQDVTLKDKIDQLQSDY QDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIG QCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQ RMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDL EPSPQPPLSRAEAIKQVKHFRALQEQARTYLDL LCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQA QNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRR HSELELNIAQNMVSQVKDFVKKLQSKQASVNTI IEKVNKLTKKEESPEHKEINHLNDQWLDLCRQS NNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTE WDNLARSDAESTAVHLEALKKLALALQERKYAI EDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRW FQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEW AEEQQPNIAEALKQSPPPDMAQNLLMDHLAICS ELEAKQMLLKSLIKDADRVMADLGLNERQVIQK ALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFL MAVFQATSQIQQHERKIMFREHICLLPDDVSKQ VKTCKSAQASLKTYQNEVTGLWAQGRELMKEVT EQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEK NLVSRKHFKEDFDKACHWLKQADIVTFPEINLM NESSELHTQLAKYQNILEQSPEYENLLLTLQRT GQTILPSLNEVDHSYLSEKLNALPRQFNVIVALA KDKFYKVQEAILARKEYASLIELTTQSLSELEA QFLRMSKVPTDLAVEEALSLQDGCRAILDEVAG LGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLY HRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLER QLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSL QDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQ SWQGELKLLTSAIGETVTECESRMVQSIDFQTE MSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIR KIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELI SADLEHSLAELSELDGDIQEALRTRQATLTEIY SQCQRYYQVFQAANDWLEDAQELLQLAGNGLDV ESAEENLKSHMEFFSTEDQFHSNLEELHSLVATL DPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQ VDLLQRCTAQWHDYQKAREEVIELMNDTEKKLS EFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKI VALEEKASQLEKTGNDASKATLSRSMTTVWQRW TRLRAVAQDQEKILEDAVDEWTGFNNKVKKATE MIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVL ELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPP LMQEITAMQDRCLNMQEKVKTNGKLVKQELKDR EMVETQINSVKCWVQETKEYLGNPTIEIDAQLEE LQILLTEATNHRQNIEKMAEEQKEKYLGLYTIL PSELSLQLAEVALDLKIRDQIQDKIKEVEQSKA TSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAK TDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQ LGKPLAKKIGKLTELHQQTIRQAENRLSKLNQA ASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSA SQLREQYILHQTLLEESKEIDSELEAMTEKLQY LTSVYCTEKMSQQVAELGRETEELRQMIKIRLQ NLQDAAKDMKKFEAELKKLQAALEQAQATLTSPE VGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLC QSALRIPEDVVASLPLCHAALRLQEEASRLQHT AIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHR EIEDKPVATSNIQELQAQISRHEELAQKIKGYQ EQIASLNSKCKMLTMKAKHATMLLTVTEVEGLA EGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSP VTEESGEEGTNSEISSPPACRSPSPVANTDASV NQDIAYYQALSAERLQTDAAKIHPSTSASQEFY EPGLEPSATAKLGDLQRSWETLKNVISEKQRTLY EALERQQKYQDSLQSISTKMEAIELKLSESPEP GRSPESQMAEHQALMDEILMLQDEINELQSSLA EELVSESCEADPAEQLALQSTLTVLAERMSTIRM KASGKRQLLEEKLNDQLEEQRQEQALQRYRCEA DELDSWLLSTKATLDTALSPPKEPMDMEAQLMD CQNMLVEIEQKVVALSELSVHNENLLLEGKAHTK DEAEQLAGKLRRLKGSLLELQRALHDKQLNMQG TAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ QRQSSLQQQKELEQELAEQKSLLRSVASRGEEIL IQHSAAETSGDAGEKPDVLSQELGMEGEKSSAE DQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVL YSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLN QAFEEVSSQSGGAKRQSIHLEQKLYDGVSATST WLDDVEERLFVATALLPEETETCLFNQEILAKD IKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLG CLLGRLSLLDSVVNQRCHQMKERLQQILNFQND LKVLFTSLADNKYIILQKLANVFEQPVAEQIEA IQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQE LSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYE RALQDLADLLETGQEKMAGDQKIIVSSKEEIQQ LLDKHKEYFQGLESHMILTETLFRKIISFAVQKE TQFHTELMAQASAVLKRAHKRGVELEYILETWS HLDEDQQELSRQLEVVESSIPSVGLVEENEDRL IDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLIS ISCSDLESQLNQLGECWLSNTNKMSKELHRLET ILKHWTRYQSESADLIHWLQSAKDRLEFWTQQS VTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSV LSTGNQLLRLKKVDTATLRSELSRIDSQWTDLL TNIPAVQEKLHQLQMDKLPSRHAISEVMSWISL MENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKID INCKQLTVDFVNQSVLQISSQDVESKRSDKTDF AEQLGAMNKSWQILQGLVTEKIQLLEGLLESWS EYENNVQCLKTWFETQEKRLKQQHRIGDQASVQN ALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNK KEDVSSIVMSTLRELGQTWANLDHMVGQLKILL KSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLL TGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGS ITNQLLKECHPPVTETLTNTLKEVNMRWNNLLE EIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQE DRTNELLKAATNKDIADDEVATWIQDCNDLLKG LGTVKDSLFFLHELGEQLKQQVDASAASAIQSD QLSLSQHLCALEQALCKQQTSLQAGVLDYETFAK SLEALEAWIVEAEEILQGQDPSHSSDLSTIQER MEELKGQMLKFSSMAPDLDRLNELGYRLPLNDK EIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQ TFLEKCETWMEFLVQTEQKLAVEISGNYQHLLE QQRAHELFQAEMFSRQQILHSIIIDGQRLLEQG QVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIID SQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGS VPIPLQQARTLFDEVQFKEKVFLRQQGSYILTV EAGKQLLLSADSGAEAALQAELAEIQEKWKSASM RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTF KKKLSQSLPDHHEELHAEQMRCKELENAVGSWT DDLTQLSLLKDTLSAYISADDISILNERVELLQR QWEELCHQLSLRRQQIGERLNEWAVFSEKNKEL CEWLTQMESKVSQNGDILIEEMIEKLKKDYQEE IAIAQENKIQLQQMGERLAKASHESKASEIEYKL GKVNDRWQHLLDLIAARVKKLKETLVAVQQLDK NMSSLRTWLAHIESELAKPIVYDSCNSEEIQRK LNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA CATDAECDSIQQATRNLDRRWRNICAMSMERRL KIEETWRLWQKFLDDYSRFEDWLKSSERTAAFP SSSGVIYTVAKEELKKFEAFQRQVHECLTQLELI NKQYRRLARENRTDSACSLKQMVHEGNQRWDNL QKRVTSILRRLKHFIGQREEFETARDSILVWLT EMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLN HNKIEQIIAQGEQLIEKSEPLDAAIIEEELDEL RRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDR ELELEDSAALSDLHWHDRSADSLLSPQPSSNLSL SLAQPLRSERSGRDTPASVDSIPLEWDHDYDLS RDLESAMSRALPSEDEEGQDDKDFYLRGAVGLS DVMIPESPEAYVKLTENAIKNTSGDHSALESQIR QLGKALDDSRFQIQQTENIIRSKTPTGPELDTS YKGYMKLLGECSSSIDSVKRLEHKLKEEEESLP GFVNLHSTETQTAGVIDRWELLQAQALSKELRMK QNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRL ELSTDIQTIELQIKKLKELQKAVDHRKAIILSI NLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCS LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENI DRRKNEIVPIDSNLDAEILQDHHKQLMQIKHEL LESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVH VIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDL SSWSSADELDTSGSVSPTSGRSTPNRQKTPRGK CSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRS GRGFLFRVLRAALPLQLLLLLLIGLACLVPMSE EDYSCALSNNFARSFHPMLRYTNGPPPL*TKQM PSAEVLVA*GGSGHKQSQTTNKRTLILAKALGVA ALALLQITCVQIMASEVEDKQ*RGNKQTTRRFG RNLV*DSEP*H*GD*VRTSKVPRTHEFWALGPF CAQPRTSVDHLGSFPMVLLQPSDK*PSQAPCQCR TIYQPTSAEEILEPCNIQFLRAYMAASFLPCFP LGHDVLTFALEAQAVNLKGTFF*RYKEKLDVIN KIMEGFM*KKLNVIVKKKRYLCMYSLLKPSFVCI DFFAFIIDIIK

Sequence NM_133650

AAGGTAAAGCCACTAGAGAGAAACTGAAAGAAAACATTCTTAAGATAAATTGAATTGACATTTTCTCTCTAAAATATGATTTATAGACCACAGATAGGAA TTAAGAGTTTCCTGATAATTTTGGCTTCATATTATTTTAAAGGATTATCAAGAGGAAATTGCTATTGCTCAAGAGAACAAAATACAGCTCCAACAAATGG GAGAACGACTTGCTAAAGCCAGCCATGAAAGCAAAGCATCTGAGATTGAATACAAGCTGGGAAAGGTCAACGACCGGTGGCAGCATCTCCTGGACCTCAT TGCAGCCAGGGTGAAGAAGCTGAAGGAGACCCTGGTAGCCGTGCAGCAGCTTGATAAGAACATGAGCAGCCTGAGGACCTGGCTCGCTCACATCGAGTCA GAGCTGGCCAAGCCAATAGTCTACGATTCCTGTAACTCGGAAGAAATACAGAGAAAGCTTAATGAGCAGCAGGAGCTTCAGAGAGACATAGAGAAGCACA GTACAGGTGTTGCATCTGTCCTCAACCTGTGTGAAGTCCTGCTGCACGACTGTGACGCCTGTGCCACTGATGCCGAGTGTGACTCTATACAGCAGGCTAC GAGAAACCTGGACCGGCGGTGGAGAAACATTTGTGCTATGTCCATGGAAAGGAGGCTGAAAATCGAAGAGACGTGGCGATTGTGGCAGAAATTTCTGGAT GACTATTCACGTTTTGAAGATTGGCTGAAGTCTTCAGAAAGGACAGCTGCTTTTCCCAGCTCTTCTGGGGTGATCTATACAGTTGCCAAGGAAGAACTAA AGAAATTTGAGGCTTTCCAGCGACAGGTCCACGAGTGCCTGACGCAGCTGGAACTGATCAACAAGCAGTACCGCCGCCTGGCCAGGGAGAACCGCACTGA TTCAGCATGTAGCCTCAAACAGATGGTTCACGAAGGCAACCAGAGATGGGACAACCTGCAAAAGCGTGTCACCTCCATCTTGCGCAGACTCAAGCATTTT ATTGGCCAGCGTGAGGAGTTTGAGACTGCGCGGGACAGCATTCTGGTCTGGCTCACAGAGATGGATCTGCAGCTCACTAATATTGAACATTTTTCTGAGT GTGATGTTCAAGCTAAAATAAAGCAACTCAAGGCCTTCCAGCAGGAAATTTCACTGAACCACAATAAGATTGAGCAGATAATTGCCCAAGGAGAACAGCT GATAGAAAAGAGTGAGCCCTTGGATGCAGCGATCATCGAGGAGGAACTAGATGAGCTCCGACGGTACTGCCAGGAGGTCTTCGGGCGTGTGGAAAGATAC CATAAGAAACTGATCCGCCTGCCTCTCCCAGACGATGAGCACGACCTCTCAGACAGGGAGCTGGAGCTGGAAGACTCTGCAGCTCTGTCGGACCTGCACT GGCACGACCGCTCTGCAGACAGCCTGCTTTCTCCACAGCCTTCCTCCAATCTCTCCCTCTCGCTCGCTCAGCCCCTCCGGAGCGAGCGGTCAGGACGAGA CACCCCGGCTAGTGTGGACTCCATCCCCCTGGAGTGGGATCACGACTATGACCTCAGTCGGGACCTGGAGTCTGCAATGTCCAGAGCTCTGCCCTCTGAG GATGAAGAAGGTCAGGATGACAAAGATTTCTACCTCCGGGGAGCTGTTGGCTTATCAGATGTAATGATCCCCGAAAGCCCTGAGGCCTATGTAAAACTCA CAGAAAATGCAATCAAAAATACCTCCGGGGACCACAGTGCCCTAGAGTCACAGATCCGACAACTGGGCAAAGCCCTGGATGATAGCCGTTTTCAGATACA GCAAACCGAAAATATCATTCGCAGCAAAACTCCCACGGGGCCGGAGCTAGACACCAGCTACAAAGGCTACATGAAACTGCTGGGCGAATGCAGTAGCAGT ATAGACTCCGTGAAGAGACTGGAGCACAAACTGAAGGAGGAAGAGGAGAGCCTTCCTGGCTTTGTTAACCTGCATAGTACCGAAACCCAAACGGCTGGTG TGATTGACCGATGGGAGCTTCTCCAGGCCCAGGCATTGAGCAAGGAGTTGAGGATGAAGCAGAACCTCCAGAAGTGGCAGCAGTTTAACTCAGACTTGAA CAGCATCTGGGCCTGGCTGGGGGACACGGAGGAGGAGTTGGAACAGCTCCAGCGTCTGGAACTCAGCACTGACATCCAGACCATCGAGCTCCAGATCAAA AAGCTCAAGGAGCTCCAGAAAGCTGTGGACCACCGCAAAGCCATCATCCTCTCCATCAATCTCTGCAGCCCTGAGTTCACCCAGGCTGACAGCAAGGAGA GCCGGGACCTGCAGGATCGCTTGTCGCAGATGAATGGGCGCTGGGACCGAGTGTGCTCTCTGCTGGAGGAGTGGCGGGGCCTGCTGCAGGATGCCCTGAT GCAGTGCCAGGGTTTCCATGAAATGAGCCATGGTTTGCTTCTTATGCTGGAGAACATTGACAGAAGGAAAAATGAAATTGTCCCTATTGATTCTAACCTT GATGCAGAGATACTTCAGGACCATCACAAACAGCTTATGCAAATAAAGCATGAGCTGTTGGAATCCCAACTCAGAGTAGCCTCTTTGCAAGACATGTCTT GCCAACTACTGGTGAATGCTGAAGGAACAGACTGTTTAGAAGCCAAAGAAAAAGTCCATGTTATTGGAAATCGGCTCAAACTTCTCTTGAAGGAGGTCAG TCGTCATATCAAGGAACTGGAGAAGTTATTAGACGTGTCAAGTAGTCAGCAGGATTTGTCTTCCTGGTCTTCTGCTGATGAACTGGACACCTCAGGGTCT GTGAGTCCCACATCAGGAAGGAGCACCCCAAACAGACAGAAAACGCCACGAGGCAAGTGTAGTCTCTCACAGCCTGGACCCTCTGTCAGCAGTCCACATA GCAGGTCCACAAAAGGTGGCTCCGATTCCTCCCTTTCTGAGCCAGGGCCAGGTCGGTCCGGCCGCGGCTTCCTGTTCAGAGTCCTCCGAGCAGCTCTTCC CCTTCAGCTTCTCCTGCTCCTCCTCATCGGGCTTGCCTGCCTTGTACCAATGTCAGAGGAAGACTACAGCTGTGCCCTCTCCAACAACTTTGCCCGGTCA TTCCACCCCATGCTCAGATACACGAATGGCCCTCCTCCACTCTGAACTAAGCAGATGCCATCTGCAGAAGTGCTGGTAGCATAAGGAGGATCGGGTCATA AGCAATCCCAAACTACCAACAAGAGGACCTTGATCTTGGCGAAAGCCCTCGGTGTGGCAGCTTTAGCCCTCCTCCAGATCACATGTGTGCAAATTATGGC TTCAGAGGTGGAAGATAAACAGTGACGGGGGAACAAACAGACAACAAGAAGGTTTGGAAGAAATCTGGTTTGAGACTCTGAACCTTAGCACTAAGGAGAT TGAGTAAGGACCTCCAAAGTTCCCCGGACTCATGAATTCTGGGCCCTTGGCCCATTCTGTGCACAGCCAAGGACTTCAGTAGACCATCTGGGCAGCTTTC CCATGGTGCTGCTCCAACCATCAGATAAATGACCCTCCCAAGCACCATGTCAGTGTCGTACAATCTACCAACCAACCAGTGCTGAAGAGATTTTAGAACC TTGTAACATACAATTTTTAAGAGCTTATATGGCAGCTTCCTTTTTACCTTGTTTTCCTTTGGGGCATGATGTTTTAACCTTTGCTTTAGAAGCACAAGCT GTAAATCTAAAAGGCACTTTTTTTTAGAGGTATAAAGAAAAACTAGATGTAATAAATAAGATCATGGAAGGCTTTATGTGAAAAAAGTTGAATGTTATAG TAAAAAAAAAAAGATATTTATGTATGTACAGTTTGCTAAAGCCAAGTTTTGTTTGTATTGATTTCTTTGCATTTATTATAGATATTATAAAAT

refseq_SYNE1.F5 (forward primer)
refseq_SYNE1.R5 (reverse primer)
Single exon skipping

Frame 0

KVKPLERN*KKTFLR*IELTFSL*NMIYRPQIG IKSFLIILASYYFKGLSRGNCYCSREQNTAPTNG RTTC*SQP*KQSI*D*IQAGKGQRPVAASPGPH CSQGEEAEGDPGSRAAA**EHEQPEDLARSHRV RAGQANSLRFL*LGRNTEKA**AAGASERHREAQ YRCCICPQPV*SPAARL*RLCH*CRV*LYTAGY EKPGPAVEKHLCYVHGKEAENRRDVAIVAEISG *LFTF*RLAEVFRKDSCFSQLFWGDLYSCQGRTK EI*GFPATGPRVPDAAGTDQQAVPPPGQGEPH* FSM*PQTDGSRRQPEMGQPAKACHLHLAQTQAF YWPA*GV*DCAGQHSGLAHRDGSAAH*Y*TFF*V *CSS*NKATQGLPAGNFTEPQ*D*ADNCPRRTA DRKE*ALGCSDHRGGTR*APTVLPGGLRACGKI P*ETDPPASPRR*ARPLRQGAGAGRLCSSVGPAL ARPLCRQPAFSTAFLQSLPLARSAPPERAVRTR HPG*CGLHPPGVGSRL*PQSGPGVCNVQSSAL* G*RRSG*QRFLPPGSCWLIRCNDPRKP*GLCKTH RKCNQKYLRGPQCPRVTDPTTGQSPG**PFSDT ANRKYHSQQNSHGAGARHQLQRLHETAGRMQ*Q YRLREETGAQTEGGRGEPSWLC*PA*YRNPNGWC D*PMGASPGPGIEQGVEDEAEPPEVAAV*LRLE QHLGLAGGHGGGVGTAPASGTQH*HPDHRAPDQ KAQGAPESCGPPQSHHPLHQSLQP*VHPG*QQGE PGPAGSLVADEWALGPSVLSAGGVAGPAAGCPD AVPGFP*NEPWFASYAGEH*QKEK*NCPY*F*P *CRDTSGPSQTAYANKA*AVGIPTQSSLFARHVL PTTGEC*RNRLFRSQRKSPCYWKSAQTSLEGGQ SSYQGTGEVIRRVK*SAGFVFLVFC**TGHLRV CESHIRKEHPKQTENATRQV*SLTAWTLCQQST* QVHKRWLRFLPF*ARARSVRPRLPVQSPPSSSS PSASPAPPHRACLPCTNVRGRLQLCPLQQLCPV IPPHAQIHEWPSSTLN*ADAICRSAGSIRRIGS* AIPNYQQEDLDLGESPRCGSFSPPPDHMCANYG FRGGR*TVTGEQTDNKKVWKKSGLRL*TLALRR LSKDLQSSPDS*ILGPWPILCTAKDFSRPSGQLS HGAAPTIR*MTLPSTMSVSYNLPTNQC*RDFRT L*HTIFKSLYGSFLFTLFSFGA*CFNLCFRSTS CKSKRHFFLEV*RKTRCNK*DHGRLYVKKVECYS KKKKIFMYVQFAKAKFCLY*FLCIYYRYYK

Frame 1

R*SH*RETERKHS*DKLN*HFLSKI*FIDHR*E LRVS**FWLHIILKDYQEEIAIAQENKIQLQQM GERLAKASHESKASEIEYKLGKVNDRWQHLLDLI AARVKKLKETLVAVQQLDKNMSSLRTWLAHIES ELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKH STGVASVLNLCEVLLHDCDACATDAECDSIQQAT RNLDRRWRNICAMSMERRLKIEETWRLWQKFLD DYSRFEDWLKSSERTAAFPSSSGVIYTVAKEEL KKFEAFQRQVHECLTQLELINKQYRRLARENRTD SACSLKQMVHEGNQRWDNLQKRVTSILRRLKHF IGQREEFETARDSILVWLTEMDLQLTNIEHFSE CDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQL IEKSEPLDAAIIEEELDELRRYCQEVFGRVERY HKKLIRLPLPDDEHDLSDRELELEDSAALSDLH WHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRD TPASVDSIPLEWDHDYDLSRDLESAMSRALPSE DEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKL TENAIKNTSGDHSALESQIRQLGKALDDSRFQIQ QTENIIRSKTPTGPELDTSYKGYMKLLGECSSS IDSVKRLEHKLKEEEESLPGFVNLHSTETQTAG VIDRWELLQAQALSKELRMKQNLQKWQQFNSDLN SIWAWLGDTEEELEQLQRLELSTDIQTIELQIK KLKELQKAVDHRKAIILSINLCSPEFTQADSKE SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALM QCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNL DAEILQDHHKQLMQIKHELLESQLRVASLQDMS CQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVS RHIKELEKLLDVSSSQQDLSSWSSADELDTSGS VSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPH SRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALP LQLLLLLLIGLACLVPMSEEDYSCALSNNFARS FHPMLRYTNGPPPL*TKQMPSAEVLVA*GGSGH KQSQTTNKRTLILAKALGVAALALLQITCVQIMA SEVEDKQ*RGNKQTTRRFGRNLV*DSEP*H*GD *VRTSKVPRTHEFWALGPFCAQPRTSVDHLGSF PMVLLQPSDK*PSQAPCQCRTIYQPTSAEEILEP CNIQFLRAYMAASFLPCFPLGHDVLTFALEAQA VNLKGTFF*RYKEKLDVINKIMEGFM*KKLNVI VKKKRYLCMYSLLKPSFVCIDFFAFIIDIIK

Frame 2

GKATREKLKENILKIN*IDIFSLKYDL*TTDRN *EFPDNFGFILF*RIIKRKLLLLKRTKYSSNKW ENDLLKPAMKAKHLRLNTSWERSTTGGSISWTS LQPG*RS*RRPW*PCSSLIRT*AA*GPGSLTSSQ SWPSQ*STIPVTRKKYRESLMSSRSFRET*RST VQVLHLSSTCVKSCCTTVTPVPLMPSVTLYSRL RETWTGGGETFVLCPWKGG*KSKRRGDCGRNFWM TIHVLKIG*SLQKGQLLFPALLG*SIQLPRKN* RNLRLSSDRSTSA*RSWN*STSSTAAWPGRTAL IQHVASNRWFTKATRDGTTCKSVSPPSCADSSIL LASVRSLRLRGTAFWSGSQRWICSSLILNIFLS VMFKLK*SNSRPSSRKFH*TTIRLSR*LPKENS **KRVSPWMQRSSRRN*MSSDGTARRSSGVWKDT IRN*SACLSQTMSTTSQTGSWSWKTLQLCRTCT GTTALQTACFLHSLPPISPSRSLSPSGASGQDE TPRLVWTPSPWSGITTMTSVGTWSLQCPELCPLR MKKVRMTKISTSGELLAYQM**SPKALRPM*NS QKMQSKIPPGTTVP*SHRSDNWAKPWMIAVFRY SKPKISFAAKLPRGRS*TPATKAT*NCWANAVAV *TP*RDWSTN*RRKRRAFLALLTCIVPKPKRLV *LTDGSFSRPRH*ARS*G*SRTSRSGSSLTQT* TASGPGWGTRRRSWNSSSVWNSALTSRPSSSRSK SSRSSRKLWTTAKPSSSPSISAALSSPRLTARR AGTCRIACRR*MGAGTECALCWRSGGACCRMP* CSARVSMK*AMVCFLCWRTLTEGKMKLSLLILTL MQRYFRTITNSLCK*SMSCWNPNSE*PLCKTCL ANYW*MLKEQTV*KPKKKSMLLEIGSNFS*RRS VVISRNWRSY*TCQVVSRICLPGLLLMNWTPQGL *VPHQEGAPQTDRKRHEASVVSHSLDPLSAVHI AGPQKVAPIPPFLSQGQVGPAAASCSESSEQLF PFSFSCSSSSGLPALYQCQRKTTAVPSPTTLPGH STPCSDTRMALLHSELSRCHLQKCW*HKEDRVI SNPKLPTRGP*SWRKPSVWQL*PSSRSHVCKLW LQRWKINSDGGTNRQQEGLEEIWFETLNLSTKEI E*GPPKFPGLMNSGPLAHSVHSQGLQ*TIWAAF PWCCSNHQINDPPKHHVSVVQSTNQPVLKRF*N LVTYNF*ELIWQLPFYLVFLWGMMF*PLL*KHKL *I*KALFFRGIKKN*M**IRSWKALCEKS*ML* *KKKDIYVCTVC*SQVLFVLISLHLL*IL*N