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Sequence NM_001121
GACGCTCGAGGGGCGCTCGGCTAGTCCCGCCAGAGCGCGAGCCGCCAGCCCGTAACGGTCGCCAGTGTGAGGGGCGGGAGGGAAAGAAGAGGGGTTTAAATTAGATTTTTTAAAACACAGAGCAAGCGCCAGAGGCGTCGGCATCCCAGGTGTCGCCGCTTCCTGCTGCACAGGGCTCGGCGTACAGGTCCCTCCCTCCT
CAAGCCCCCTCCCCTTCTCCCGCCCTACCCTCTGGGGCTCTGCGGCGCTTAAGAGGCGGCCGCAGCGGCGGATCCGGCGGCTGCTGCAGCCCGGGCGGCT
GCCGAGAAGGAGGGAGGGGAAACACAAAGCCGGCTACGCGCTGCGAGATAACAAGAGTAATCCACAGACTTAAAACATGAGCTCAGATGCCAGCCAAGGC
GTGATTACCACTCCTCCTCCTCCCAGCATGCCTCACAAAGAGAGATATTTTGACCGCATCAATGAAAATGACCCAGAATACATTAGGGAGAGGAACATGT
CTCCTGATCTACGACAAGACTTCAACATGATGGAGCAGAGGAAACGAGTTACTCAGATCCTGCAAAGTCCTGCCTTTCGGGAAGACTTGGAATGCCTTAT
TCAAGAACAGATGAAGAAAGGCCACAACCCAACTGGATTACTAGCATTACAGCAGATTGCAGATTACATCATGGCCAATTCTTTCTCGGGTTTTTCTTCA
CCTCCTCTCAGTCTTGGCATGGTCACACCTATCAATGACCTTCCTGGTGCAGATACATCCTCATATGTGAAGGGAGAAAAACTTACTCGCTGTAAACTTG
CCAGCCTGTACAGACTTGTAGACTTGTTTGGATGGGCACACCTGGCAAATACCTATATCTCAGTAAGAATAAGTAAGGAGCAAGACCACATTATAATAAT
TCCCAGAGGCCTATCTTTTTCTGAAGCTACAGCCTCCAATTTGGTGAAAGTCAATATAATAGGAGAAGTGGTTGACCAGGGAAGTACCAATTTGAAAATT
GACCATACAGGATTCAGTCCCCATGCTGCAATCTATTCAACACGTCCTGATGTTAAGTGTGTGATACACATCCATACCCTTGCAACAGCAGCTGTATCCT
CCATGAAATGTGGGATCCTTCCAATTTCTCAAGAGTCTCTTCTTCTGGGAGATGTTGCCTATTATGACTACCAAGGGTCACTTGAAGAACAGGAGGAGAG
AATTCAACTGCAGAAGGTTCTGGGACCAAGTTGTAAGGTGCTGGTACTCAGGAATCATGGTGTGGTTGCACTTGGAGAAACATTAGAGGAGGCTTTTCAT
TATATTTTTAATGTGCAACTAGCCTGTGAGATTCAGGTGCAGGCCCTAGCAGGTGCAGGTGGAGTAGACAATCTCCATGTACTGGACTTTCAGAAGTATA
AAGCTTTCACTTACACTGTAGCAGCGTCTGGTGGAGGAGGTGTGAATATGGGTTCCCATCAAAAATGGAAGGTTGGCGAAATTGAGTTTGAAGGGCTTAT
GAGGACTCTGGACAACTTGGGGTATAGAACAGGCTATGCTTACAGGCATCCTCTCATTCGAGAGAAGCCTAGGCACAAGAGTGATGTGGAAATCCCAGCA
ACTGTGACTGCTTTTTCCTTTGAAGACGATACAGTGCCACTCTCTCCTCTCAAATACATGGCACAGAGGCAACAGCGTGAAAAAACAAGATGGCTGAACT
CACCAAATACTTACATGAAAGTGAATGTGCCTGAGGAGTCTCGGAACGGAGAAACCAGTCCCCGAACCAAAATCACGTGGATGAAAGCAGAAGACTCATC
TAAAGTTAGTGGTGGAACACCTATCAAAATTGAAGATCCAAATCAGTTTGTTCCTTTAAACACAAACCCGAATGAGGTACTAGAAAAGAGAAATAAGATT
CGGGAACAAAATCGATATGACTTGAAAACAGCAGGACCACAATCTCAGTTGCTTGCTGGAATTGTTGTGGATAAGCCACCTTCTACTATGCAATTTGAAG
ATGATGATCATGGCCCACCAGCTCCTCCTAACCCATTTAGTCATCTCACAGAAGGAGAACTTGAAGAGTATAAGAGGACAATCGAACGTAAACAACAAGG
CCTAGAAGAAAACCATGAGCTGTTTTCCAAGAGCTTCATCTCCATGGAAGTGCCTGTCATGGTAGTAAATGGCAAGGATGATATGCATGATGTTGAAGAT
GAGCTTGCTAAGCGAGTGAGTAGGTTAAGCACAAGTACAACCATAGAAAACATCGAGATTACTATTAAGTCTCCAGAGAAAATCGAAGAAGTCCTGTCAC
CTGAAGGCTCCCCTTCAAAATCGCCATCCAAGAAAAAGAAGAAATTCCGCACTCCTTCTTTTCTGAAAAAGAACAAAAAAAAGGAGAAAGTTGAGGCCTA
AATAAAGTCTTTTTATAATTATTATTATAACAATGTGACATTGCACATCTAAATACCACATTTAAGTTGATCATTAATATGCAATGGTAGATCAGATTGG
GGGATGTAGCAAACTGGACTTTAAGAACTGGAAAGAGGTTTTACAAAAGAAAAACTTTCAGATTCATCTCTCATTTTATATGTCCAGAAATGGCTTTGAA
TTTTAAGCAATTACTAGTTTTAATTAGCTCTGCCCTCATGAAGTATTATTATAATTCACCATAAACAGCTATCTGTCTGAATTACTTCAGGCCTTCTCCA
TAATATCTGTTAGAAAGAAATTGCCAGTGAGCAAGTGAGAATTTTTATTTCTCAATACCTGCTTCACTTGATAATCATATTATAATTTTTTATCATGATT
ATTGACTATATTTTTGGAGTCCCATTGTTTCAGTGGGCATTAACAGAATGCTTTAAAAACTTCTAAGACAAGAATCTATAGCATTAGTATACACTGGCAC
ATAATTTTTTAAAAAGTTTTAAGAAAAGATTCATTTGGAATTTTATTCACAGTATAAAATTTCCTCACCTGAAGTAACTTTGTTTGCCAAAAAAGTTGTT
TTAATAAACTATAATTTTTGAAAACTTCCTTTTTTATTAGTTTAGAAAGCCCCTTATTTTTCAACAAAGGGGATTTTGTACACATAACATGGGTTATTTA
GTTTAACTCTGGCAAAAAAAAAAAAAAAAATTTTGTATGTTGATGTTTGTATACCGTTCAGTATAAAAGTGTCCTAAGCATATTAGCCAATCTTTTCACA
GTAGAGCATACTTAAGGCTGCTTGGTACTGAGTATACTTAAATATAACTCCAGAATCCAGGGACTTGGTGTTAAAACAGGATTAGAGCATGTAAAGGTAC
ATCTAGATTCATATTTGAATCTTAAACTGTATTTTTCTCTTAGTATTGCTAATGAGTAAAGAAAAGTCTCATAAGGTAGCCAAATGAAAAAGAATGAAAG
GGAAAGTGAAAAATTAAGGGGACAAAAGATGGGATGTGAAAAGAAGAATTCTAGTTTGATGGTGACTCATATTCACGATAGGATACAAAGTGTGATTTGT
TGGAAACATGTCCCAAATTTCTAAAATTCTGCTTCTCTGCCAAAAGCAATGTCTTTCTTGGTTGATATTTGAGTTTTAAAAGGGTCAAATCTTTCTAATT
TTTTGTATCTTTAGAGGGCAGCACTAGAAGAAATCAGCAGGTCTAATCCCACCAGTAAGAAAACTACCACTTCTTGATTTTTACAGATTTAAAAAAATCT
TTTCAGTGACCTTTCTTTTTAATGTAAATACAAATTTAAACCTAGGCTTAATATAGGCGTTTCCCCTTTCACCCAAGTGATGTCACAGTTCGATGCAAAA
TCAATGATCCAGAATGATCGTGGGTAAAAATAACTCAAAGTGTTTCTTAAGGGTGAGTTGGCATGCAAAAAATTACATTGATTACAGTGTGTTTTGGAGC
TGGCTCTGTTTGTGTGCATATGATAATGCAGAGTTGAGCCAGAGCCTGGAAATGTCATTCTAGATCTCACTAACTACTGGAATCAGTGTTTTAATCTCTT
GGTGGAAACTTTCAGTTGCTTAACTCTCTATTGGAAGATTTTTTTAATGTTCTACATCATTTATGTTGTATTACAATGTATGTAGAAATAGTAACCTGTG
AACTATGCTTTTCCATAACTTTTTAAAAATATATATATCTAAATGAATGCAATGTGCATAAATATTTTTTAAACATAACAGTGAACTATTGCACCTTTTG
CTAATGCCTCTATTTACTTGCTTTGGCATAAAGAATGAGCCAATGAACCTCTGTGTCCTGTGGAAAAATGTATAAATGTTATCTGATATTGCTCTTAGAT
GTAATGCTAATTAATGTTAAATCACAAATAAACAGTATTTTAAATATA
- refseq_ADD3.F2 (forward primer)
- refseq_ADD3.R2 (reverse primer)
- Single exon skipping
Frame 0
DARGALG*SRQSASRQPVTVASVRGGRERRGV*IRFFKTQSKRQRRRHPRCRRFLLHRARRTGPSLL
KPPPLLPPYPLGLCGA*EAAAAADPAAAAARAA
AEKEGGETQSRLRAAR*QE*STDLKHELRCQPR
RDYHSSSSQHASQREIF*PHQ*K*PRIH*GEEHV
S*STTRLQHDGAEETSYSDPAKSCLSGRLGMPY
SRTDEERPQPNWITSITADCRLHHGQFFLGFFF
TSSQSWHGHTYQ*PSWCRYILICEGRKTYSL*TC
QPVQTCRLVWMGTPGKYLYLSKNK*GARPHYNN
SQRPIFF*SYSLQFGESQYNRRSG*PGKYQFEN
*PYRIQSPCCNLFNTS*C*VCDTHPYPCNSSCIL
HEMWDPSNFSRVSSSGRCCLL*LPRVT*RTGGE
NSTAEGSGTKL*GAGTQESWCGCTWRNIRGGFS
LYF*CATSL*DSGAGPSRCRWSRQSPCTGLSEV*
SFHLHCSSVWWRRCEYGFPSKMEGWRN*V*RAY
EDSGQLGV*NRLCLQASSHSREA*AQE*CGNPS
NCDCFFL*RRYSATLSSQIHGTEATA*KNKMAEL
TKYLHESECA*GVSERRNQSPNQNHVDESRRLI
*S*WWNTYQN*RSKSVCSFKHKPE*GTRKEK*D
SGTKSI*LENSRTTISVACWNCCG*ATFYYAI*R
**SWPTSSS*PI*SSHRRRT*RV*EDNRT*TTR
PRRKP*AVFQELHLHGSACHGSKWQG*YA*C*R
*AC*ASE*VKHKYNHRKHRDYY*VSRENRRSPVT
*RLPFKIAIQEKEEIPHSFFSEKEQKKGES*GL
NKVFL*LLL*QCDIAHLNTTFKLIINMQW*IRL
GDVANWTLRTGKRFYKRKTFRFISHFICPEMALN
FKQLLVLISSALMKYYYNSP*TAICLNYFRPSP
*YLLERNCQ*ASENFYFSIPASLDNHIIIFYHD
Y*LYFWSPIVSVGINRML*KLLRQESIALVYTGT
*FFKKF*EKIHLEFYSQYKISSPEVTLFAKKVV
LINYNF*KLPFLLV*KAPYFSTKGILYT*HGLF
SLTLAKKKKKILYVDVCIPFSIKVS*AY*PIFSQ
*SILKAAWY*VYLNITPESRDLVLKQD*SM*RY
I*IHI*ILNCIFLLVLLMSKEKSHKVAK*KRMK
GKVKN*GDKRWDVKRRILV*W*LIFTIGYKV*FV
GNMSQISKILLLCQKQCLSWLIFEF*KGQIFLI
FCIFRGQH*KKSAGLIPPVRKLPLLDFYRFKKI
FSVTFLFNVNTNLNLGLI*AFPLSPK*CHSSMQN
Q*SRMIVGKNNSKCFLRVSWHAKNYIDYSVFWS
WLCLCAYDNAELSQSLEMSF*ISLTTGISVLIS
WWKLSVA*LSIGRFF*CSTSFMLYYNVCRNSNL*
TMLFHNFLKIYISK*MQCA*IFFKHNSELLHLL
LMPLFTCFGIKNEPMNLCVLWKNV*MLSDIALR
CNAN*C*ITNKQYFKY
Frame 1
TLEGRSASPARARAASP*RSPV*GAGGKEEGFKLDFLKHRASARGVGIPGVAASCCTGLGVQVPPS
SSPLPFSRPTLWGSAALKRRPQRRIRRLLQPGRL
PRRREGKHKAGYALRDNKSNPQT*NMSSDASQG
VITTPPPPSMPHKERYFDRINENDPEYIRERNM
SPDLRQDFNMMEQRKRVTQILQSPAFREDLECLI
QEQMKKGHNPTGLLALQQIADYIMANSFSGFSS
PPLSLGMVTPINDLPGADTSSYVKGEKLTRCKL
ASLYRLVDLFGWAHLANTYISVRISKEQDHIIII
PRGLSFSEATASNLVKVNIIGEVVDQGSTNLKI
DHTGFSPHAAIYSTRPDVKCVIHIHTLATAAVS
SMKCGILPISQESLLLGDVAYYDYQGSLEEQEER
IQLQKVLGPSCKVLVLRNHGVVALGETLEEAFH
YIFNVQLACEIQVQALAGAGGVDNLHVLDFQKY
KAFTYTVAASGGGGVNMGSHQKWKVGEIEFEGLM
RTLDNLGYRTGYAYRHPLIREKPRHKSDVEIPA
TVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLN
SPNTYMKVNVPEESRNGETSPRTKITWMKAEDSS
KVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKI
REQNRYDLKTAGPQSQLLAGIVVDKPPSTMQFE
DDDHGPPAPPNPFSHLTEGELEEYKRTIERKQQG
LEENHELFSKSFISMEVPVMVVNGKDDMHDVED
ELAKRVSRLSTSTTIENIEITIKSPEKIEEVLS
PEGSPSKSPSKKKKKFRTPSFLKKNKKKEKVEA*
IKSFYNYYYNNVTLHI*IPHLS*SLICNGRSDW
GM*QTGL*ELERGFTKEKLSDSSLILYVQKWL*
ILSNY*F*LALPS*SIIIIHHKQLSV*ITSGLLH
NIC*KEIASEQVRIFISQYLLHLIIIL*FFIMI
IDYIFGVPLFQWALTECFKNF*DKNL*H*YTLA
HNFLKSFKKRFIWNFIHSIKFPHLK*LCLPKKLF
**TIIFENFLFY*FRKPLIFQQRGFCTHNMGYL
V*LWQKKKKKFCMLMFVYRSV*KCPKHISQSFH
SRAYLRLLGTEYT*I*LQNPGTWC*NRIRACKGT
SRFIFES*TVFFS*YC**VKKSLIR*PNEKE*K
GK*KIKGTKDGM*KEEF*FDGDSYSR*DTKCDL
LETCPKFLKFCFSAKSNVFLG*YLSFKRVKSF*F
FVSLEGSTRRNQQV*SHQ*ENYHFLIFTDLKKS
FQ*PFFLM*IQI*T*A*YRRFPFHPSDVTVRCK
INDPE*SWVKITQSVS*G*VGMQKITLITVCFGA
GSVCVHMIMQS*ARAWKCHSRSH*LLESVF*SL
GGNFQLLNSLLEDFFNVLHHLCCITMYVEIVTC
ELCFSITF*KYIYLNECNVHKYFLNITVNYCTFC
*CLYLLALA*RMSQ*TSVSCGKMYKCYLILLLD
VMLINVKSQINSILNI
Frame 2
RSRGARLVPPEREPPARNGRQCEGREGKKRGLN*IF*NTEQAPEASASQVSPLPAAQGSAYRSLPP
QAPSPSPALPSGALRRLRGGRSGGSGGCCSPGG
CREGGRGNTKPATRCEITRVIHRLKT*AQMPAKA
*LPLLLLPACLTKRDILTASMKMTQNTLGRGTC
LLIYDKTST*WSRGNELLRSCKVLPFGKTWNAL
FKNR*RKATTQLDY*HYSRLQITSWPILSRVFLH
LLSVLAWSHLSMTFLVQIHPHM*REKNLLAVNL
PACTDL*TCLDGHTWQIPISQ*E*VRSKTTL**
FPEAYLFLKLQPPIW*KSI**EKWLTREVPI*KL
TIQDSVPMLQSIQHVLMLSV*YTSIPLQQQLYP
P*NVGSFQFLKSLFFWEMLPIMTTKGHLKNRRR
EFNCRRFWDQVVRCWYSGIMVWLHLEKH*RRLFI
IFLMCN*PVRFRCRP*QVQVE*TISMYWTFRSI
KLSLTL*QRLVEEV*IWVPIKNGRLAKLSLKGL
*GLWTTWGIEQAMLTGILSFERSLGTRVMWKSQQ
L*LLFPLKTIQCHSLLSNTWHRGNSVKKQDG*T
HQILT*K*MCLRSLGTEKPVPEPKSRG*KQKTH
LKLVVEHLSKLKIQISLFL*TQTRMRY*KREIRF
GNKIDMT*KQQDHNLSCLLELLWISHLLLCNLK
MMIMAHQLLLTHLVISQKENLKSIRGQSNVNNK
A*KKTMSCFPRASSPWKCLSW**MARMICMMLKM
SLLSE*VG*AQVQP*KTSRLLLSLQRKSKKSCH
LKAPLQNRHPRKRRNSALLLF*KRTKKRRKLRP
K*SLFIIIIITM*HCTSKYHI*VDH*YAMVDQIG
GCSKLDFKNWKEVLQKKNFQIHLSFYMSRNGFE
F*AITSFN*LCPHEVLL*FTINSYLSELLQAFS
IISVRKKLPVSK*EFLFLNTCFT**SYYNFLS*L
LTIFLESHCFSGH*QNALKTSKTRIYSISIHWH
IIF*KVLRKDSFGILFTV*NFLT*SNFVCQKSC
FNKL*FLKTSFFISLESPLFFNKGDFVHITWVI*
FNSGKKKKKNFVC*CLYTVQYKSVLSILANLFT
VEHT*GCLVLSILKYNSRIQGLGVKTGLEHVKV
HLDSYLNLKLYFSLSIANE*RKVS*GSQMKKNER
ESEKLRGQKMGCEKKNSSLMVTHIHDRIQSVIC
WKHVPNF*NSASLPKAMSFLVDI*VLKGSNLSN
FLYL*RAALEEISRSNPTSKKTTTS*FLQI*KNL
FSDLSF*CKYKFKPRLNIGVSPFTQVMSQFDAK
SMIQNDRG*K*LKVFLKGELACKKLH*LQCVLE
LALFVCI**CRVEPEPGNVILDLTNYWNQCFNLL
VETFSCLTLYWKIFLMFYIIYVVLQCM*K**PV
NYAFP*LFKNIYI*MNAMCINIF*T*Q*TIAPF
ANASIYLLWHKE*ANEPLCPVEKCINVI*YCS*M
*C*LMLNHK*TVF*I
Sequence NM_019903
GAGAGAAGCTGCTGCTGCTAATGCTGCTGCTGCTGCTGCCGCCGCCGCCGCTGCTGCTGCTGCTGTTGGTCTGAGGCTGCAGTAGGTTTCTGTGCAGCATTGCAGAATCCACACCTAGAGAACAGAAGACACAGACACGTACGTCTACTACCCTTGTTAGAAGGAAGCTTTGGATCTTCGGTGGATAACAAGAGTAATCC
ACAGACTTAAAACATGAGCTCAGATGCCAGCCAAGGCGTGATTACCACTCCTCCTCCTCCCAGCATGCCTCACAAAGAGAGATATTTTGACCGCATCAAT
GAAAATGACCCAGAATACATTAGGGAGAGGAACATGTCTCCTGATCTACGACAAGACTTCAACATGATGGAGCAGAGGAAACGAGTTACTCAGATCCTGC
AAAGTCCTGCCTTTCGGGAAGACTTGGAATGCCTTATTCAAGAACAGATGAAGAAAGGCCACAACCCAACTGGATTACTAGCATTACAGCAGATTGCAGA
TTACATCATGGCCAATTCTTTCTCGGGTTTTTCTTCACCTCCTCTCAGTCTTGGCATGGTCACACCTATCAATGACCTTCCTGGTGCAGATACATCCTCA
TATGTGAAGGGAGAAAAACTTACTCGCTGTAAACTTGCCAGCCTGTACAGACTTGTAGACTTGTTTGGATGGGCACACCTGGCAAATACCTATATCTCAG
TAAGAATAAGTAAGGAGCAAGACCACATTATAATAATTCCCAGAGGCCTATCTTTTTCTGAAGCTACAGCCTCCAATTTGGTGAAAGTCAATATAATAGG
AGAAGTGGTTGACCAGGGAAGTACCAATTTGAAAATTGACCATACAGGATTCAGTCCCCATGCTGCAATCTATTCAACACGTCCTGATGTTAAGTGTGTG
ATACACATCCATACCCTTGCAACAGCAGCTGTATCCTCCATGAAATGTGGGATCCTTCCAATTTCTCAAGAGTCTCTTCTTCTGGGAGATGTTGCCTATT
ATGACTACCAAGGGTCACTTGAAGAACAGGAGGAGAGAATTCAACTGCAGAAGGTTCTGGGACCAAGTTGTAAGGTGCTGGTACTCAGGAATCATGGTGT
GGTTGCACTTGGAGAAACATTAGAGGAGGCTTTTCATTATATTTTTAATGTGCAACTAGCCTGTGAGATTCAGGTGCAGGCCCTAGCAGGTGCAGGTGGA
GTAGACAATCTCCATGTACTGGACTTTCAGAAGTATAAAGCTTTCACTTACACTGTAGCAGCGTCTGGTGGAGGAGGTGTGAATATGGGTTCCCATCAAA
AATGGAAGGTTGGCGAAATTGAGTTTGAAGGGCTTATGAGGACTCTGGACAACTTGGGGTATAGAACAGGCTATGCTTACAGGCATCCTCTCATTCGAGA
GAAGCCTAGGCACAAGAGTGATGTGGAAATCCCAGCAACTGTGACTGCTTTTTCCTTTGAAGACGATACAGTGCCACTCTCTCCTCTCAAATACATGGCA
CAGAGGCAACAGCGTGAAAAAACAAGATGGCTGAACTCACCAAATACTTACATGAAAGTGAATGTGCCTGAGGAGTCTCGGAACGGAGAAACCAGTCCCC
GAACCAAAATCACGTGGATGAAAGCAGAAGACTCATCTAAAGTTAGTGGTGGAACACCTATCAAAATTGAAGATCCAAATCAGTTTGTTCCTTTAAACAC
AAACCCGAATGAGGTACTAGAAAAGAGAAATAAGATTCGGGAACAAAATCGATATGACTTGAAAACAGCAGGACCACAATCTCAGTTGCTTGCTGGAATT
GTTGTGGATAAGCCACCTTCTACTATGCAATTTGAAGATGATGATCATGGCCCACCAGCTCCTCCTAACCCATTTAGTCATCTCACAGAAGGAGAACTTG
AAGAGTATAAGAGGACAATCGAACGTAAACAACAAGGCCTAGAAGAAAACCATGAGCTGTTTTCCAAGAGCTTCATCTCCATGGAAGTGCCTGTCATGGT
AGTAAATGGCAAGGATGATATGCATGATGTTGAAGATGAGCTTGCTAAGCGAGTGAGTAGGTTAAGCACAAGTACAACCATAGAAAACATCGAGATTACT
ATTAAGTCTCCAGAGAAAATCGAAGAAGTCCTGTCACCTGAAGGCTCCCCTTCAAAATCGCCATCCAAGAAAAAGAAGAAATTCCGCACTCCTTCTTTTC
TGAAAAAGAACAAAAAAAAGGAGAAAGTTGAGGCCTAAATAAAGTCTTTTTATAATTATTATTATAACAATGTGACATTGCACATCTAAATACCACATTT
AAGTTGATCATTAATATGCAATGGTAGATCAGATTGGGGGATGTAGCAAACTGGACTTTAAGAACTGGAAAGAGGTTTTACAAAAGAAAAACTTTCAGAT
TCATCTCTCATTTTATATGTCCAGAAATGGCTTTGAATTTTAAGCAATTACTAGTTTTAATTAGCTCTGCCCTCATGAAGTATTATTATAATTCACCATA
AACAGCTATCTGTCTGAATTACTTCAGGCCTTCTCCATAATATCTGTTAGAAAGAAATTGCCAGTGAGCAAGTGAGAATTTTTATTTCTCAATACCTGCT
TCACTTGATAATCATATTATAATTTTTTATCATGATTATTGACTATATTTTTGGAGTCCCATTGTTTCAGTGGGCATTAACAGAATGCTTTAAAAACTTC
TAAGACAAGAATCTATAGCATTAGTATACACTGGCACATAATTTTTTAAAAAGTTTTAAGAAAAGATTCATTTGGAATTTTATTCACAGTATAAAATTTC
CTCACCTGAAGTAACTTTGTTTGCCAAAAAAGTTGTTTTAATAAACTATAATTTTTGAAAACTTCCTTTTTTATTAGTTTAGAAAGCCCCTTATTTTTCA
ACAAAGGGGATTTTGTACACATAACATGGGTTATTTAGTTTAACTCTGGCAAAAAAAAAAAAAAAAATTTTGTATGTTGATGTTTGTATACCGTTCAGTA
TAAAAGTGTCCTAAGCATATTAGCCAATCTTTTCACAGTAGAGCATACTTAAGGCTGCTTGGTACTGAGTATACTTAAATATAACTCCAGAATCCAGGGA
CTTGGTGTTAAAACAGGATTAGAGCATGTAAAGGTACATCTAGATTCATATTTGAATCTTAAACTGTATTTTTCTCTTAGTATTGCTAATGAGTAAAGAA
AAGTCTCATAAGGTAGCCAAATGAAAAAGAATGAAAGGGAAAGTGAAAAATTAAGGGGACAAAAGATGGGATGTGAAAAGAAGAATTCTAGTTTGATGGT
GACTCATATTCACGATAGGATACAAAGTGTGATTTGTTGGAAACATGTCCCAAATTTCTAAAATTCTGCTTCTCTGCCAAAAGCAATGTCTTTCTTGGTT
GATATTTGAGTTTTAAAAGGGTCAAATCTTTCTAATTTTTTGTATCTTTAGAGGGCAGCACTAGAAGAAATCAGCAGGTCTAATCCCACCAGTAAGAAAA
CTACCACTTCTTGATTTTTACAGATTTAAAAAAATCTTTTCAGTGACCTTTCTTTTTAATGTAAATACAAATTTAAACCTAGGCTTAATATAGGCGTTTC
CCCTTTCACCCAAGTGATGTCACAGTTCGATGCAAAATCAATGATCCAGAATGATCGTGGGTAAAAATAACTCAAAGTGTTTCTTAAGGGTGAGTTGGCA
TGCAAAAAATTACATTGATTACAGTGTGTTTTGGAGCTGGCTCTGTTTGTGTGCATATGATAATGCAGAGTTGAGCCAGAGCCTGGAAATGTCATTCTAG
ATCTCACTAACTACTGGAATCAGTGTTTTAATCTCTTGGTGGAAACTTTCAGTTGCTTAACTCTCTATTGGAAGATTTTTTTAATGTTCTACATCATTTA
TGTTGTATTACAATGTATGTAGAAATAGTAACCTGTGAACTATGCTTTTCCATAACTTTTTAAAAATATATATATCTAAATGAATGCAATGTGCATAAAT
ATTTTTTAAACATAACAGTGAACTATTGCACCTTTTGCTAATGCCTCTATTTACTTGCTTTGGCATAAAGAATGAGCCAATGAACCTCTGTGTCCTGTGG
AAAAATGTATAAATGTTATCTGATATTGCTCTTAGATGTAATGCTAATTAATGTTAAATCACAAATAAACAGTATTTTAAATATA
- refseq_ADD3.F2 (forward primer)
- refseq_ADD3.R2 (reverse primer)
- Single exon skipping
Frame 0
ERSCCC*CCCCCCRRRRCCCCCWSEAAVGFCAALQNPHLENRRHRHVRLLPLLEGSFGSSVDNKSNP
QT*NMSSDASQGVITTPPPPSMPHKERYFDRIN
ENDPEYIRERNMSPDLRQDFNMMEQRKRVTQIL
QSPAFREDLECLIQEQMKKGHNPTGLLALQQIAD
YIMANSFSGFSSPPLSLGMVTPINDLPGADTSS
YVKGEKLTRCKLASLYRLVDLFGWAHLANTYIS
VRISKEQDHIIIIPRGLSFSEATASNLVKVNIIG
EVVDQGSTNLKIDHTGFSPHAAIYSTRPDVKCV
IHIHTLATAAVSSMKCGILPISQESLLLGDVAY
YDYQGSLEEQEERIQLQKVLGPSCKVLVLRNHGV
VALGETLEEAFHYIFNVQLACEIQVQALAGAGG
VDNLHVLDFQKYKAFTYTVAASGGGGVNMGSHQ
KWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLIRE
KPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMA
QRQQREKTRWLNSPNTYMKVNVPEESRNGETSP
RTKITWMKAEDSSKVSGGTPIKIEDPNQFVPLNT
NPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGI
VVDKPPSTMQFEDDDHGPPAPPNPFSHLTEGEL
EEYKRTIERKQQGLEENHELFSKSFISMEVPVMV
VNGKDDMHDVEDELAKRVSRLSTSTTIENIEIT
IKSPEKIEEVLSPEGSPSKSPSKKKKKFRTPSF
LKKNKKKEKVEA*IKSFYNYYYNNVTLHI*IPHL
S*SLICNGRSDWGM*QTGL*ELERGFTKEKLSD
SSLILYVQKWL*ILSNY*F*LALPS*SIIIIHH
KQLSV*ITSGLLHNIC*KEIASEQVRIFISQYLL
HLIIIL*FFIMIIDYIFGVPLFQWALTECFKNF
*DKNL*H*YTLAHNFLKSFKKRFIWNFIHSIKF
PHLK*LCLPKKLF**TIIFENFLFY*FRKPLIFQ
QRGFCTHNMGYLV*LWQKKKKKFCMLMFVYRSV
*KCPKHISQSFHSRAYLRLLGTEYT*I*LQNPG
TWC*NRIRACKGTSRFIFES*TVFFS*YC**VKK
SLIR*PNEKE*KGK*KIKGTKDGM*KEEF*FDG
DSYSR*DTKCDLLETCPKFLKFCFSAKSNVFLG
*YLSFKRVKSF*FFVSLEGSTRRNQQV*SHQ*EN
YHFLIFTDLKKSFQ*PFFLM*IQI*T*A*YRRF
PFHPSDVTVRCKINDPE*SWVKITQSVS*G*VG
MQKITLITVCFGAGSVCVHMIMQS*ARAWKCHSR
SH*LLESVF*SLGGNFQLLNSLLEDFFNVLHHL
CCITMYVEIVTCELCFSITF*KYIYLNECNVHK
YFLNITVNYCTFC*CLYLLALA*RMSQ*TSVSCG
KMYKCYLILLLDVMLINVKSQINSILNI
Frame 1
REAAAANAAAAAAAAAAAAAAVGLRLQ*VSVQHCRIHT*RTEDTDTYVYYPC*KEALDLRWITRVI
HRLKT*AQMPAKA*LPLLLLPACLTKRDILTASM
KMTQNTLGRGTCLLIYDKTST*WSRGNELLRSC
KVLPFGKTWNALFKNR*RKATTQLDY*HYSRLQ
ITSWPILSRVFLHLLSVLAWSHLSMTFLVQIHPH
M*REKNLLAVNLPACTDL*TCLDGHTWQIPISQ
*E*VRSKTTL**FPEAYLFLKLQPPIW*KSI**
EKWLTREVPI*KLTIQDSVPMLQSIQHVLMLSV*
YTSIPLQQQLYPP*NVGSFQFLKSLFFWEMLPI
MTTKGHLKNRRREFNCRRFWDQVVRCWYSGIMV
WLHLEKH*RRLFIIFLMCN*PVRFRCRP*QVQVE
*TISMYWTFRSIKLSLTL*QRLVEEV*IWVPIK
NGRLAKLSLKGL*GLWTTWGIEQAMLTGILSFE
RSLGTRVMWKSQQL*LLFPLKTIQCHSLLSNTWH
RGNSVKKQDG*THQILT*K*MCLRSLGTEKPVP
EPKSRG*KQKTHLKLVVEHLSKLKIQISLFL*T
QTRMRY*KREIRFGNKIDMT*KQQDHNLSCLLEL
LWISHLLLCNLKMMIMAHQLLLTHLVISQKENL
KSIRGQSNVNNKA*KKTMSCFPRASSPWKCLSW
**MARMICMMLKMSLLSE*VG*AQVQP*KTSRLL
LSLQRKSKKSCHLKAPLQNRHPRKRRNSALLLF
*KRTKKRRKLRPK*SLFIIIIITM*HCTSKYHI
*VDH*YAMVDQIGGCSKLDFKNWKEVLQKKNFQI
HLSFYMSRNGFEF*AITSFN*LCPHEVLL*FTI
NSYLSELLQAFSIISVRKKLPVSK*EFLFLNTC
FT**SYYNFLS*LLTIFLESHCFSGH*QNALKTS
KTRIYSISIHWHIIF*KVLRKDSFGILFTV*NF
LT*SNFVCQKSCFNKL*FLKTSFFISLESPLFF
NKGDFVHITWVI*FNSGKKKKKNFVC*CLYTVQY
KSVLSILANLFTVEHT*GCLVLSILKYNSRIQG
LGVKTGLEHVKVHLDSYLNLKLYFSLSIANE*R
KVS*GSQMKKNERESEKLRGQKMGCEKKNSSLMV
THIHDRIQSVICWKHVPNF*NSASLPKAMSFLV
DI*VLKGSNLSNFLYL*RAALEEISRSNPTSKK
TTTS*FLQI*KNLFSDLSF*CKYKFKPRLNIGVS
PFTQVMSQFDAKSMIQNDRG*K*LKVFLKGELA
CKKLH*LQCVLELALFVCI**CRVEPEPGNVIL
DLTNYWNQCFNLLVETFSCLTLYWKIFLMFYIIY
VVLQCM*K**PVNYAFP*LFKNIYI*MNAMCIN
IF*T*Q*TIAPFANASIYLLWHKE*ANEPLCPV
EKCINVI*YCS*M*C*LMLNHK*TVF*I
Frame 2
EKLLLLMLLLLLPPPPLLLLLLV*GCSRFLCSIAESTPREQKTQTRTSTTLVRRKLWIFGG*QE*S
TDLKHELRCQPRRDYHSSSSQHASQREIF*PHQ
*K*PRIH*GEEHVS*STTRLQHDGAEETSYSDPA
KSCLSGRLGMPYSRTDEERPQPNWITSITADCR
LHHGQFFLGFFFTSSQSWHGHTYQ*PSWCRYIL
ICEGRKTYSL*TCQPVQTCRLVWMGTPGKYLYLS
KNK*GARPHYNNSQRPIFF*SYSLQFGESQYNR
RSG*PGKYQFEN*PYRIQSPCCNLFNTS*C*VC
DTHPYPCNSSCILHEMWDPSNFSRVSSSGRCCLL
*LPRVT*RTGGENSTAEGSGTKL*GAGTQESWC
GCTWRNIRGGFSLYF*CATSL*DSGAGPSRCRW
SRQSPCTGLSEV*SFHLHCSSVWWRRCEYGFPSK
MEGWRN*V*RAYEDSGQLGV*NRLCLQASSHSR
EA*AQE*CGNPSNCDCFFL*RRYSATLSSQIHG
TEATA*KNKMAELTKYLHESECA*GVSERRNQSP
NQNHVDESRRLI*S*WWNTYQN*RSKSVCSFKH
KPE*GTRKEK*DSGTKSI*LENSRTTISVACWN
CCG*ATFYYAI*R**SWPTSSS*PI*SSHRRRT*
RV*EDNRT*TTRPRRKP*AVFQELHLHGSACHG
SKWQG*YA*C*R*AC*ASE*VKHKYNHRKHRDY
Y*VSRENRRSPVT*RLPFKIAIQEKEEIPHSFFS
EKEQKKGES*GLNKVFL*LLL*QCDIAHLNTTF
KLIINMQW*IRLGDVANWTLRTGKRFYKRKTFR
FISHFICPEMALNFKQLLVLISSALMKYYYNSP*
TAICLNYFRPSP*YLLERNCQ*ASENFYFSIPA
SLDNHIIIFYHDY*LYFWSPIVSVGINRML*KL
LRQESIALVYTGT*FFKKF*EKIHLEFYSQYKIS
SPEVTLFAKKVVLINYNF*KLPFLLV*KAPYFS
TKGILYT*HGLFSLTLAKKKKKILYVDVCIPFS
IKVS*AY*PIFSQ*SILKAAWY*VYLNITPESRD
LVLKQD*SM*RYI*IHI*ILNCIFLLVLLMSKE
KSHKVAK*KRMKGKVKN*GDKRWDVKRRILV*W
*LIFTIGYKV*FVGNMSQISKILLLCQKQCLSWL
IFEF*KGQIFLIFCIFRGQH*KKSAGLIPPVRK
LPLLDFYRFKKIFSVTFLFNVNTNLNLGLI*AF
PLSPK*CHSSMQNQ*SRMIVGKNNSKCFLRVSWH
AKNYIDYSVFWSWLCLCAYDNAELSQSLEMSF*
ISLTTGISVLISWWKLSVA*LSIGRFF*CSTSF
MLYYNVCRNSNL*TMLFHNFLKIYISK*MQCA*I
FFKHNSELLHLLLMPLFTCFGIKNEPMNLCVLW
KNV*MLSDIALRCNAN*C*ITNKQYFKY
Sequence NM_016824
GACGCTCGAGGGGCGCTCGGCTAGTCCCGCCAGAGCGCGAGCCGCCAGCCCGTAACGGTCGCCAGTGTGAGGGGCGGGAGGGAAAGAAGAGGGGTTTAAATTAGATTTTTTAAAACACAGAGCAAGCGCCAGAGGCGTCGGCATCCCAGGTGTCGCCGCTTCCTGCTGCACAGGGCTCGGCGTACAGGTCCCTCCCTCCT
CAAGCCCCCTCCCCTTCTCCCGCCCTACCCTCTGGGGCTCTGCGGCGCTTAAGAGGCGGCCGCAGCGGCGGATCCGGCGGCTGCTGCAGCCCGGGCGGCT
GCCGAGAAGGAGGGAGGGGAAACACAAAGCCGGCTACGCGCTGCGAGATAACAAGAGTAATCCACAGACTTAAAACATGAGCTCAGATGCCAGCCAAGGC
GTGATTACCACTCCTCCTCCTCCCAGCATGCCTCACAAAGAGAGATATTTTGACCGCATCAATGAAAATGACCCAGAATACATTAGGGAGAGGAACATGT
CTCCTGATCTACGACAAGACTTCAACATGATGGAGCAGAGGAAACGAGTTACTCAGATCCTGCAAAGTCCTGCCTTTCGGGAAGACTTGGAATGCCTTAT
TCAAGAACAGATGAAGAAAGGCCACAACCCAACTGGATTACTAGCATTACAGCAGATTGCAGATTACATCATGGCCAATTCTTTCTCGGGTTTTTCTTCA
CCTCCTCTCAGTCTTGGCATGGTCACACCTATCAATGACCTTCCTGGTGCAGATACATCCTCATATGTGAAGGGAGAAAAACTTACTCGCTGTAAACTTG
CCAGCCTGTACAGACTTGTAGACTTGTTTGGATGGGCACACCTGGCAAATACCTATATCTCAGTAAGAATAAGTAAGGAGCAAGACCACATTATAATAAT
TCCCAGAGGCCTATCTTTTTCTGAAGCTACAGCCTCCAATTTGGTGAAAGTCAATATAATAGGAGAAGTGGTTGACCAGGGAAGTACCAATTTGAAAATT
GACCATACAGGATTCAGTCCCCATGCTGCAATCTATTCAACACGTCCTGATGTTAAGTGTGTGATACACATCCATACCCTTGCAACAGCAGCTGTATCCT
CCATGAAATGTGGGATCCTTCCAATTTCTCAAGAGTCTCTTCTTCTGGGAGATGTTGCCTATTATGACTACCAAGGGTCACTTGAAGAACAGGAGGAGAG
AATTCAACTGCAGAAGGTTCTGGGACCAAGTTGTAAGGTGCTGGTACTCAGGAATCATGGTGTGGTTGCACTTGGAGAAACATTAGAGGAGGCTTTTCAT
TATATTTTTAATGTGCAACTAGCCTGTGAGATTCAGGTGCAGGCCCTAGCAGGTGCAGGTGGAGTAGACAATCTCCATGTACTGGACTTTCAGAAGTATA
AAGCTTTCACTTACACTGTAGCAGCGTCTGGTGGAGGAGGTGTGAATATGGGTTCCCATCAAAAATGGAAGGTTGGCGAAATTGAGTTTGAAGGGCTTAT
GAGGACTCTGGACAACTTGGGGTATAGAACAGGCTATGCTTACAGGCATCCTCTCATTCGAGAGAAGCCTAGGCACAAGAGTGATGTGGAAATCCCAGCA
ACTGTGACTGCTTTTTCCTTTGAAGACGATACAGTGCCACTCTCTCCTCTCAAATACATGGCACAGAGGCAACAGCGTGAAAAAACAAGATGGCTGAACT
CACCAAATACTTACATGAAAGTGAATGTGCCTGAGGAGTCTCGGAACGGAGAAACCAGTCCCCGAACCAAAATCACGTGGATGAAAGCAGAAGACTCATC
TAAAGTTAGTGGTGGAACACCTATCAAAATTGAAGATCCAAATCAGTTTGTTCCTTTAAACACAAACCCGAATGAGGTACTAGAAAAGAGAAATAAGATT
CGGGAACAAAATCGATATGACTTGAAAACAGCAGGACCACAATCTCAGTTGCTTGCTGGAATTGTTGTGGATAAGCCACCTTCTACTATGCAATTTGAAG
ATGATGATCATGGCCCACCAGCTCCTCCTAACCCATTTAGTCATCTCACAGAAGGAGAACTTGAAGAGTATAAGAGGACAATCGAACGTAAACAACAAGG
CCTAGAAGATGCTGAGCAGGAATTACTCTCAGATGACGCTTCATCTGTTTCACAAATTCAGTCTCAAACTCAGTCACCGCAAAATGTCCCTGAAAAATTA
GAAGAAAACCATGAGCTGTTTTCCAAGAGCTTCATCTCCATGGAAGTGCCTGTCATGGTAGTAAATGGCAAGGATGATATGCATGATGTTGAAGATGAGC
TTGCTAAGCGAGTGAGTAGGTTAAGCACAAGTACAACCATAGAAAACATCGAGATTACTATTAAGTCTCCAGAGAAAATCGAAGAAGTCCTGTCACCTGA
AGGCTCCCCTTCAAAATCGCCATCCAAGAAAAAGAAGAAATTCCGCACTCCTTCTTTTCTGAAAAAGAACAAAAAAAAGGAGAAAGTTGAGGCCTAAATA
AAGTCTTTTTATAATTATTATTATAACAATGTGACATTGCACATCTAAATACCACATTTAAGTTGATCATTAATATGCAATGGTAGATCAGATTGGGGGA
TGTAGCAAACTGGACTTTAAGAACTGGAAAGAGGTTTTACAAAAGAAAAACTTTCAGATTCATCTCTCATTTTATATGTCCAGAAATGGCTTTGAATTTT
AAGCAATTACTAGTTTTAATTAGCTCTGCCCTCATGAAGTATTATTATAATTCACCATAAACAGCTATCTGTCTGAATTACTTCAGGCCTTCTCCATAAT
ATCTGTTAGAAAGAAATTGCCAGTGAGCAAGTGAGAATTTTTATTTCTCAATACCTGCTTCACTTGATAATCATATTATAATTTTTTATCATGATTATTG
ACTATATTTTTGGAGTCCCATTGTTTCAGTGGGCATTAACAGAATGCTTTAAAAACTTCTAAGACAAGAATCTATAGCATTAGTATACACTGGCACATAA
TTTTTTAAAAAGTTTTAAGAAAAGATTCATTTGGAATTTTATTCACAGTATAAAATTTCCTCACCTGAAGTAACTTTGTTTGCCAAAAAAGTTGTTTTAA
TAAACTATAATTTTTGAAAACTTCCTTTTTTATTAGTTTAGAAAGCCCCTTATTTTTCAACAAAGGGGATTTTGTACACATAACATGGGTTATTTAGTTT
AACTCTGGCAAAAAAAAAAAAAAAAATTTTGTATGTTGATGTTTGTATACCGTTCAGTATAAAAGTGTCCTAAGCATATTAGCCAATCTTTTCACAGTAG
AGCATACTTAAGGCTGCTTGGTACTGAGTATACTTAAATATAACTCCAGAATCCAGGGACTTGGTGTTAAAACAGGATTAGAGCATGTAAAGGTACATCT
AGATTCATATTTGAATCTTAAACTGTATTTTTCTCTTAGTATTGCTAATGAGTAAAGAAAAGTCTCATAAGGTAGCCAAATGAAAAAGAATGAAAGGGAA
AGTGAAAAATTAAGGGGACAAAAGATGGGATGTGAAAAGAAGAATTCTAGTTTGATGGTGACTCATATTCACGATAGGATACAAAGTGTGATTTGTTGGA
AACATGTCCCAAATTTCTAAAATTCTGCTTCTCTGCCAAAAGCAATGTCTTTCTTGGTTGATATTTGAGTTTTAAAAGGGTCAAATCTTTCTAATTTTTT
GTATCTTTAGAGGGCAGCACTAGAAGAAATCAGCAGGTCTAATCCCACCAGTAAGAAAACTACCACTTCTTGATTTTTACAGATTTAAAAAAATCTTTTC
AGTGACCTTTCTTTTTAATGTAAATACAAATTTAAACCTAGGCTTAATATAGGCGTTTCCCCTTTCACCCAAGTGATGTCACAGTTCGATGCAAAATCAA
TGATCCAGAATGATCGTGGGTAAAAATAACTCAAAGTGTTTCTTAAGGGTGAGTTGGCATGCAAAAAATTACATTGATTACAGTGTGTTTTGGAGCTGGC
TCTGTTTGTGTGCATATGATAATGCAGAGTTGAGCCAGAGCCTGGAAATGTCATTCTAGATCTCACTAACTACTGGAATCAGTGTTTTAATCTCTTGGTG
GAAACTTTCAGTTGCTTAACTCTCTATTGGAAGATTTTTTTAATGTTCTACATCATTTATGTTGTATTACAATGTATGTAGAAATAGTAACCTGTGAACT
ATGCTTTTCCATAACTTTTTAAAAATATATATATCTAAATGAATGCAATGTGCATAAATATTTTTTAAACATAACAGTGAACTATTGCACCTTTTGCTAA
TGCCTCTATTTACTTGCTTTGGCATAAAGAATGAGCCAATGAACCTCTGTGTCCTGTGGAAAAATGTATAAATGTTATCTGATATTGCTCTTAGATGTAA
TGCTAATTAATGTTAAATCACAAATAAACAGTATTTTAAATATA
- refseq_ADD3.F2 (forward primer)
- refseq_ADD3.R2 (reverse primer)
- Single exon skipping
Frame 0
DARGALG*SRQSASRQPVTVASVRGGRERRGV*IRFFKTQSKRQRRRHPRCRRFLLHRARRTGPSLL
KPPPLLPPYPLGLCGA*EAAAAADPAAAAARAA
AEKEGGETQSRLRAAR*QE*STDLKHELRCQPR
RDYHSSSSQHASQREIF*PHQ*K*PRIH*GEEHV
S*STTRLQHDGAEETSYSDPAKSCLSGRLGMPY
SRTDEERPQPNWITSITADCRLHHGQFFLGFFF
TSSQSWHGHTYQ*PSWCRYILICEGRKTYSL*TC
QPVQTCRLVWMGTPGKYLYLSKNK*GARPHYNN
SQRPIFF*SYSLQFGESQYNRRSG*PGKYQFEN
*PYRIQSPCCNLFNTS*C*VCDTHPYPCNSSCIL
HEMWDPSNFSRVSSSGRCCLL*LPRVT*RTGGE
NSTAEGSGTKL*GAGTQESWCGCTWRNIRGGFS
LYF*CATSL*DSGAGPSRCRWSRQSPCTGLSEV*
SFHLHCSSVWWRRCEYGFPSKMEGWRN*V*RAY
EDSGQLGV*NRLCLQASSHSREA*AQE*CGNPS
NCDCFFL*RRYSATLSSQIHGTEATA*KNKMAEL
TKYLHESECA*GVSERRNQSPNQNHVDESRRLI
*S*WWNTYQN*RSKSVCSFKHKPE*GTRKEK*D
SGTKSI*LENSRTTISVACWNCCG*ATFYYAI*R
**SWPTSSS*PI*SSHRRRT*RV*EDNRT*TTR
PRRC*AGITLR*RFICFTNSVSNSVTAKCP*KI
RRKP*AVFQELHLHGSACHGSKWQG*YA*C*R*A
C*ASE*VKHKYNHRKHRDYY*VSRENRRSPVT*
RLPFKIAIQEKEEIPHSFFSEKEQKKGES*GLN
KVFL*LLL*QCDIAHLNTTFKLIINMQW*IRLGD
VANWTLRTGKRFYKRKTFRFISHFICPEMALNF
KQLLVLISSALMKYYYNSP*TAICLNYFRPSP*
YLLERNCQ*ASENFYFSIPASLDNHIIIFYHDY*
LYFWSPIVSVGINRML*KLLRQESIALVYTGT*
FFKKF*EKIHLEFYSQYKISSPEVTLFAKKVVL
INYNF*KLPFLLV*KAPYFSTKGILYT*HGLFSL
TLAKKKKKILYVDVCIPFSIKVS*AY*PIFSQ*
SILKAAWY*VYLNITPESRDLVLKQD*SM*RYI
*IHI*ILNCIFLLVLLMSKEKSHKVAK*KRMKGK
VKN*GDKRWDVKRRILV*W*LIFTIGYKV*FVG
NMSQISKILLLCQKQCLSWLIFEF*KGQIFLIF
CIFRGQH*KKSAGLIPPVRKLPLLDFYRFKKIFS
VTFLFNVNTNLNLGLI*AFPLSPK*CHSSMQNQ
*SRMIVGKNNSKCFLRVSWHAKNYIDYSVFWSW
LCLCAYDNAELSQSLEMSF*ISLTTGISVLISWW
KLSVA*LSIGRFF*CSTSFMLYYNVCRNSNL*T
MLFHNFLKIYISK*MQCA*IFFKHNSELLHLLL
MPLFTCFGIKNEPMNLCVLWKNV*MLSDIALRCN
AN*C*ITNKQYFKY
Frame 1
TLEGRSASPARARAASP*RSPV*GAGGKEEGFKLDFLKHRASARGVGIPGVAASCCTGLGVQVPPS
SSPLPFSRPTLWGSAALKRRPQRRIRRLLQPGRL
PRRREGKHKAGYALRDNKSNPQT*NMSSDASQG
VITTPPPPSMPHKERYFDRINENDPEYIRERNM
SPDLRQDFNMMEQRKRVTQILQSPAFREDLECLI
QEQMKKGHNPTGLLALQQIADYIMANSFSGFSS
PPLSLGMVTPINDLPGADTSSYVKGEKLTRCKL
ASLYRLVDLFGWAHLANTYISVRISKEQDHIIII
PRGLSFSEATASNLVKVNIIGEVVDQGSTNLKI
DHTGFSPHAAIYSTRPDVKCVIHIHTLATAAVS
SMKCGILPISQESLLLGDVAYYDYQGSLEEQEER
IQLQKVLGPSCKVLVLRNHGVVALGETLEEAFH
YIFNVQLACEIQVQALAGAGGVDNLHVLDFQKY
KAFTYTVAASGGGGVNMGSHQKWKVGEIEFEGLM
RTLDNLGYRTGYAYRHPLIREKPRHKSDVEIPA
TVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLN
SPNTYMKVNVPEESRNGETSPRTKITWMKAEDSS
KVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKI
REQNRYDLKTAGPQSQLLAGIVVDKPPSTMQFE
DDDHGPPAPPNPFSHLTEGELEEYKRTIERKQQG
LEDAEQELLSDDASSVSQIQSQTQSPQNVPEKL
EENHELFSKSFISMEVPVMVVNGKDDMHDVEDE
LAKRVSRLSTSTTIENIEITIKSPEKIEEVLSPE
GSPSKSPSKKKKKFRTPSFLKKNKKKEKVEA*I
KSFYNYYYNNVTLHI*IPHLS*SLICNGRSDWG
M*QTGL*ELERGFTKEKLSDSSLILYVQKWL*IL
SNY*F*LALPS*SIIIIHHKQLSV*ITSGLLHN
IC*KEIASEQVRIFISQYLLHLIIIL*FFIMII
DYIFGVPLFQWALTECFKNF*DKNL*H*YTLAHN
FLKSFKKRFIWNFIHSIKFPHLK*LCLPKKLF*
*TIIFENFLFY*FRKPLIFQQRGFCTHNMGYLV
*LWQKKKKKFCMLMFVYRSV*KCPKHISQSFHSR
AYLRLLGTEYT*I*LQNPGTWC*NRIRACKGTS
RFIFES*TVFFS*YC**VKKSLIR*PNEKE*KG
K*KIKGTKDGM*KEEF*FDGDSYSR*DTKCDLLE
TCPKFLKFCFSAKSNVFLG*YLSFKRVKSF*FF
VSLEGSTRRNQQV*SHQ*ENYHFLIFTDLKKSF
Q*PFFLM*IQI*T*A*YRRFPFHPSDVTVRCKIN
DPE*SWVKITQSVS*G*VGMQKITLITVCFGAG
SVCVHMIMQS*ARAWKCHSRSH*LLESVF*SLG
GNFQLLNSLLEDFFNVLHHLCCITMYVEIVTCEL
CFSITF*KYIYLNECNVHKYFLNITVNYCTFC*
CLYLLALA*RMSQ*TSVSCGKMYKCYLILLLDV
MLINVKSQINSILNI
Frame 2
RSRGARLVPPEREPPARNGRQCEGREGKKRGLN*IF*NTEQAPEASASQVSPLPAAQGSAYRSLPP
QAPSPSPALPSGALRRLRGGRSGGSGGCCSPGG
CREGGRGNTKPATRCEITRVIHRLKT*AQMPAKA
*LPLLLLPACLTKRDILTASMKMTQNTLGRGTC
LLIYDKTST*WSRGNELLRSCKVLPFGKTWNAL
FKNR*RKATTQLDY*HYSRLQITSWPILSRVFLH
LLSVLAWSHLSMTFLVQIHPHM*REKNLLAVNL
PACTDL*TCLDGHTWQIPISQ*E*VRSKTTL**
FPEAYLFLKLQPPIW*KSI**EKWLTREVPI*KL
TIQDSVPMLQSIQHVLMLSV*YTSIPLQQQLYP
P*NVGSFQFLKSLFFWEMLPIMTTKGHLKNRRR
EFNCRRFWDQVVRCWYSGIMVWLHLEKH*RRLFI
IFLMCN*PVRFRCRP*QVQVE*TISMYWTFRSI
KLSLTL*QRLVEEV*IWVPIKNGRLAKLSLKGL
*GLWTTWGIEQAMLTGILSFERSLGTRVMWKSQQ
L*LLFPLKTIQCHSLLSNTWHRGNSVKKQDG*T
HQILT*K*MCLRSLGTEKPVPEPKSRG*KQKTH
LKLVVEHLSKLKIQISLFL*TQTRMRY*KREIRF
GNKIDMT*KQQDHNLSCLLELLWISHLLLCNLK
MMIMAHQLLLTHLVISQKENLKSIRGQSNVNNK
A*KMLSRNYSQMTLHLFHKFSLKLSHRKMSLKN*
KKTMSCFPRASSPWKCLSW**MARMICMMLKMS
LLSE*VG*AQVQP*KTSRLLLSLQRKSKKSCHL
KAPLQNRHPRKRRNSALLLF*KRTKKRRKLRPK*
SLFIIIIITM*HCTSKYHI*VDH*YAMVDQIGG
CSKLDFKNWKEVLQKKNFQIHLSFYMSRNGFEF
*AITSFN*LCPHEVLL*FTINSYLSELLQAFSII
SVRKKLPVSK*EFLFLNTCFT**SYYNFLS*LL
TIFLESHCFSGH*QNALKTSKTRIYSISIHWHI
IF*KVLRKDSFGILFTV*NFLT*SNFVCQKSCFN
KL*FLKTSFFISLESPLFFNKGDFVHITWVI*F
NSGKKKKKNFVC*CLYTVQYKSVLSILANLFTV
EHT*GCLVLSILKYNSRIQGLGVKTGLEHVKVHL
DSYLNLKLYFSLSIANE*RKVS*GSQMKKNERE
SEKLRGQKMGCEKKNSSLMVTHIHDRIQSVICW
KHVPNF*NSASLPKAMSFLVDI*VLKGSNLSNFL
YL*RAALEEISRSNPTSKKTTTS*FLQI*KNLF
SDLSF*CKYKFKPRLNIGVSPFTQVMSQFDAKS
MIQNDRG*K*LKVFLKGELACKKLH*LQCVLELA
LFVCI**CRVEPEPGNVILDLTNYWNQCFNLLV
ETFSCLTLYWKIFLMFYIIYVVLQCM*K**PVN
YAFP*LFKNIYI*MNAMCINIF*T*Q*TIAPFAN
ASIYLLWHKE*ANEPLCPVEKCINVI*YCS*M*
C*LMLNHK*TVF*I
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