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Sequences

Sequence NM_170663

GGCTGGCTCCGGGGAGATAGCGCCTGTCAGTCGGTGGGTCGGTCCTCGCGCCGGCCCTCCCCCTCCCCGGTCTCCGGGGGAGGCGCGGTGGAGTCCGCCC
CCGGGGTTCTCCGATGGGGGAGAAGCGGCGACGGCGGCAGTGGAGTAACCGAGCCGGAGCGTGAGCGGCCCCGGTGCCCCGTTCCCCACGGAGGCCATGG
GCGACCCAGCCCCCGCCCGCAGCCTGGACGACATCGACCTGTCCGCCCTGCGGACAGAGGACAAGGAGCAGAGACCCTGGTGATGGAGTTCTGTGGTGCT
GGTTCAGTGACTGACCTGGTAAAGAACACAAAAGGCAATGCCCTGAAGGAGGACTGTATCGCCTATATCTGCAGGGAGATCCTCAGGGGTCTGGCCCATC
TCCATGCCCACAAGGTGATCCATCGAGACATCAAGGGGCAGAATGTGCTGCTGACAGAGAATGCTGAGGTCAAGCTAGTGGATTTTGGGGTGAGTGCTCA
GCTGGACCGCACCGTGGGCAGACGGAACACTTTCATTGGGACTCCCTACTGGATGGCTCCAGAGGTCATCGCCTGTGATGAGAACCCTGATGCCACCTAT
GATTACAGGAGTGATATTTGGTCTCTAGGAATCACAGCCATCGAGATGGCAGAGGGAGCCCCCCCTCTGTGTGACATGCACCCCATGCGAGCCCTCTTCC
TCATTCCTCGGAACCCTCCGCCCAGGCTCAAGTCCAAGAAGTGGTCTAAGAAGTTCATTGACTTCATTGACACATGTCTCATCAAGACTTACCTGAGCCG
CCCACCCACGGAGCAGCTACTGAAGTTTCCCTTCATCCGGGACCAGCCCACGGAGCGGCAGGTCCGCATCCAGCTTAAGGACCACATTGACCGATCCCGG
AAGAAGCGGGGTGAGAAAGAGGAGACAGAATATGAGTACAGCGGCAGCGAGGAGGAAGATGACAGCCATGGAGAGGAAGGAGAGCCAAGCTCCATCATGA
ACGTGCCTGGAGAGTCGACTCTACGCCGGGAGTTTCTCCGGCTCCAGCAGGAAAATAAGAGCAACTCAGAGGCTTTAAAACAGCAGCAGCAGCTGCAGCA
GCAGCAGCAGCGAGACCCCGAGGCACACATCAAACACCTGCTGCACCAGCGGCAGCGGCGCATAGAGGAGCAGAAGGAGGAGCGGCGCCGCGTGGAGGAG
CAACAGCGGCGGGAGCGGGAGCAGCGGAAGCTGCAGGAGAAGGAGCAGCAGCGGCGGCTGGAGGACATGCAGGCTCTGCGGCGGGAGGAGGAGCGGCGGC
AGGCGGAGCGCGAGCAGGAATACAAGCGGAAGCAGCTGGAGGAGCAGCGGCAGTCAGAACGTCTCCAGAGGCAGCTGCAGCAGGAGCATGCCTACCTCAA
GTCCCTGCAGCAGCAGCAACAGCAGCAGCAGCTTCAGAAACAGCAGCAGCAGCAGCTCCTGCCTGGGGACAGGAAGCCCCTGTACCATTATGGTCGGGGC
ATGAATCCCGCTGACAAACCAGCCTGGGCCCGAGAGGTAGAAGAGAGAACAAGGATGAACAAGCAGCAGAACTCTCCCTTGGCCAAGAGCAAGCCAGGCA
GCACGGGGCCTGAGCCCCCCATCCCCCAGGCCTCCCCAGGGCCCCCAGGACCCCTTTCCCAGACTCCTCCTATGCAGAGGCCGGTGGAGCCCCAGGAGGG
ACCGCACAAGAGCCTGGTGGCACACCGGGTCCCACTGAAGCCATATGCAGCACCTGTACCCCGATCCCAGTCCCTGCAGGACCAGCCCACCCGAAACCTG
GCTGCCTTCCCAGCCTCCCATGACCCCGACCCTGCCATCCCCGCACCCACTGCCACGCCCAGTGCCCGAGGAGCTGTCATCCGCCAGAATTCAGACCCCA
CCTCTGAAGGACCTGGCCCCAGCCCGAATCCCCCAGCCTGGGTCCGCCCAGATAACGAGGCCCCACCCAAGGTGCCTCAGAGGACCTCATCTATCGCCAC
TGC
CCTTAACACCAGTGGGGCCGGAGGGTCCCGGCCAGCCCAGGCAGTCCGTGCCAGTAACCCCGACCTCAGGAGGAGCGACCCTGGCTGGGAACGCTCG
GACAGCGTCCTTCCAGCCTCTCACGGGCACCTCCCCCAGGCTGGCTCACTGGAGCGGAACCGCGTGGGAGTCTCCTCCAAACCGGACAGCTCCCCTGTGC
TCTCCCCTGGGAATAAAGCCAAGCCCGACGACCACCGCTCACGGCCAGGCCGGCCCGCAAGCTATAAGCGAGCAATTGGTGAGGACTTTGTGTTGCTGAA
AGAGCGGACTCTGGACGAGGCCCCTCGGCCTCCCAAGAAGGCCATGGACTACTCGTCGTCCAGCGAGGAGGTGGAAAGCAGTGAGGACGACGAGGAGGAA
GGCGAAGGCGGGCCAGCAGAGGGGAGCAGAGATACCCCTGGGGGCCGCAGCGATGGGGATACAGACAGCGTCAGCACCATGGTGGTCCACGACGTCGAGG
AGATCACCGGGACCCAGCCCCCATACGGGGGCGGCACCATGGTGGTCCAGCGCACCCCTGAAGAGGAGCGGAACCTGCTGCATGCTGACAGCAATGGGTA
CACAAACCTGCCTGACGTGGTCCAGCCCAGCCACTCACCCACCGAGAACAGCAAAGGCCAAAGCCCACCCTCGAAGGATGGGAGTGGTGACTACCAGTCT
CGTGGGCTGGTAAAGGCCCCTGGCAAGAGCTCGTTCACGATGTTTGTGGATCTAGGGATCTACCAGCCTGGAGGCAGTGGGGACAGCATCCCCATCACAG
CCCTAGTGGGTGGAGAGGGCACTCGGCTCGACCAGCTGCAGTACGACGTGAGGAAGGGTTCTGTGGTCAACGTGAATCCCACCAACACCCGGGCCCACAG
TGAGACCCCTGAGATCCGGAAGTACAAGAAGCGATTCAACTCCGAGATCCTCTGTGCAGCCCTTTGGGGGGTCAACCTGCTGGTGGGCACGGAGAACGGG
CTGATGTTGCTGGACCGAAGTGGGCAGGGCAAGGTGTATGGACTCATTGGGCGGCGACGCTTCCAGCAGATGGATGTGCTGGAGGGGCTCAACCTGCTCA
TCACCATCTCAGGGAAAAGGAACAAACTGCGGGTGTATTACCTGTCCTGGCTCCGGAACAAGATTCTGCACAATGACCCAGAAGTGGAGAAGAAGCAGGG
CTGGACCACCGTGGGGGACATGGAGGGCTGCGGGCACTACCGTGTTGTGAAATACGAGCGGATTAAGTTCCTGGTCATCGCCCTCAAGAGCTCCGTGGAG
GTGTATGCCTGGGCCCCCAAACCCTACCACAAATTCATGGCCTTCAAGTCCTTTGCCGACCTCCCCCACCGCCCTCTGCTGGTCGACCTGACAGTAGAGG
AGGGGCAGCGGCTCAAGGTCATCTATGGCTCCAGTGCTGGCTTCCATGCTGTGGATGTCGACTCGGGGAACAGCTATGACATCTACATCCCTGTGCACAT
CCAGAGCCAGATCACGCCCCATGCCATCATCTTCCTCCCCAACACCGACGGCATGGAGATGCTGCTGTGCTACGAGGACGAGGGTGTCTACGTCAACACG
TACGGGCGCATCATTAAGGATGTGGTGCTGCAGTGGGGGGAGATGCCTACTTCTGTGGCCTACATCTGCTCCAACCAGATAATGGGCTGGGGTGAGAAAG
CCATTGAGATCCGCTCTGTGGAGACGGGCCACCTCGACGGGGTCTTCATGCACAAACGAGCTCAGAGGCTCAAGTTCCTGTGTGAGCGGAATGACAAGGT
GTTTTTTGCCTCAGTCCGCTCTGGGGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGG
CTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACT
GGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCTTCCCAAAACTGTGCCTGTCCC
CAGCTTCTGGGGAGGGACACAGCTTCCCCTTCCCAGGAATTGAGTGGGCCTAGCCCCTCCCCCCTTTTCTCCATTTGAGAGGAGAGTGCTTGGGGCTTGA
ACCCCTTACCCCACTGCTGCTGACTGGGCAGGGCCCTGGACCCCTTTATTTGCACGTCAGGGGAGCCGGCTCCCCCCTTGAATGTACCAGACCCTGGGGG
GGGTCACTGGGCCCTAGATTTTTGGGGGGTCACCAGCCACTCCAGGGGCAGGGACCATTTCTTCATTTTCTGAAAGCACTTTAATGATTCCCCTTCCCCC
AAACTCCAGGGAATGGAGGGGGGACCCCGCCAGCCAAAACATTCCCCCCATTCCCGACCCCCCTCTCCTCTTCTAGCCCATGCCCTTCCCCGGTGGAGGG
AGGGAGCAGGGAGCCCTCACTCTCCACGCCCCTTGCTTGCATCTGTATATAGTGTGAGCAGCAAGTAACCCTTCTCCTCCCTCCCCCCTCCCCCCTCCTC
AATGTAGTGGCCTTGGATATCCTGTTTGTTAATAAAGACAATTCAACCAGCTCCCACCA
  • refseq_MINK1.F3 (forward primer)
  • refseq_MINK1.R3 (reverse primer)
  • Single exon skipping

Frame 0

GWLRGDSACQSVGRSSRRPSPSPVSGGGAVESA
PGVLRWGRSGDGGSGVTEPERERPRCPVPHGGHG
RPSPRPQPGRHRPVRPADRGQGAETLVMEFCGA
GSVTDLVKNTKGNALKEDCIAYICREILRGLAH
LHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQ
LDRTVGRRNTFIGTPYWMAPEVIACDENPDATY
DYRSDIWSLGITAIEMAEGAPPLCDMHPMRALF
LIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSR
PPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSR
KKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIM
NVPGESTLRREFLRLQQENKSNSEALKQQQQLQQ
QQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEE
QQRREREQRKLQEKEQQRRLEDMQALRREEERR
QAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLK
SLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRG
MNPADKPAWAREVEERTRMNKQQNSPLAKSKPG
STGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEG
PHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNL
AAFPASHDPDPAIPAPTATPSARGAVIRQNSDP
TSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIAT
A
LNTSGAGGSRPAQAVRASNPDLRRSDPGWERS
DSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV
LSPGNKAKPDDHRSRPGRPASYKRAIGEDFVLLK
ERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEE
GEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVE
EITGTQPPYGGGTMVVQRTPEEERNLLHADSNGY
TNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQS
RGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPIT
ALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHS
ETPEIRKYKKRFNSEILCAALWGVNLLVGTENG
LMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLL
ITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQG
WTTVGDMEGCGHYRVVKYERIKFLVIALKSSVE
VYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVE
EGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHI
QSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNT
YGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEK
AIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKV
FFASVRSGGSSQVYFMTLNRNCIMNW*RGPGLG
LSHTGPSSPPAARLPGPPLFPLPGLLLLLV*FH
WSLLGT*PLTPDAFVIT*PSSSPTCPLPKTVPVP
SFWGGTQLPLPRN*VGLAPPPFSPFERRVLGA*
TPYPTAADWAGPWTPLFARQGSRLPP*MYQTLG
GVTGP*IFGGSPATPGAGTISSFSESTLMIPLPP
NSREWRGDPASQNIPPIPDPPLLF*PMPFPGGG
REQGALTLHAPCLHLYIV*AASNPSPPSPLPPP
QCSGLGYPVC**RQFNQLPP

Frame 1

AGSGEIAPVSRWVGPRAGPPPPRSPGEARWSPP
PGFSDGGEAATAAVE*PSRSVSGPGAPFPTEAM
GDPAPARSLDDIDLSALRTEDKEQRPW*WSSVVL
VQ*LTW*RTQKAMP*RRTVSPISAGRSSGVWPI
SMPTR*SIETSRGRMCC*QRMLRSS*WILG*VL
SWTAPWADGTLSLGLPTGWLQRSSPVMRTLMPPM
ITGVIFGL*ESQPSRWQREPPLCVTCTPCEPSS
SFLGTLRPGSSPRSGLRSSLTSLTHVSSRLT*A
AHPRSSY*SFPSSGTSPRSGRSASSLRTTLTDPG
RSGVRKRRQNMSTAAARRKMTAMERKESQAPS*
TCLESRLYAGSFSGSSRKIRATQRL*NSSSSCS
SSSSETPRHTSNTCCTSGSGA*RSRRRSGAAWRS
NSGGSGSSGSCRRRSSSGGWRTCRLCGGRRSGG
RRSASRNTSGSSWRSSGSQNVSRGSCSRSMPTS
SPCSSSNSSSSFRNSSSSSSCLGTGSPCTIMVGA
*IPLTNQPGPER*KREQG*TSSRTLPWPRASQA
ARGLSPPSPRPPQGPQDPFPRLLLCRGRWSPRR
DRTRAWWHTGSH*SHMQHLYPDPSPCRTSPPETW
LPSQPPMTPTLPSPHPLPRPVPEELSSARIQTP
PLKDLAPARIPQPGSAQITRPHPRCLRGPHLSP
L
PLTPVGPEGPGQPRQSVPVTPTSGGATLAGNAR
TASFQPLTGTSPRLAHWSGTAWESPPNRTAPLC
SPLGIKPSPTTTAHGQAGPQAISEQLVRTLCC*
KSGLWTRPLGLPRRPWTTRRPARRWKAVRTTRRK
AKAGQQRGAEIPLGAAAMGIQTASAPWWSTTSR
RSPGPSPHTGAAPWWSSAPLKRSGTCCMLTAMG
TQTCLTWSSPATHPPRTAKAKAHPRRMGVVTTSL
VGW*RPLARARSRCLWI*GSTSLEAVGTASPSQ
P*WVERALGSTSCSTT*GRVLWST*IPPTPGPT
VRPLRSGSTRSDSTPRSSVQPFGGSTCWWARRTG
*CCWTEVGRARCMDSLGGDASSRWMCWRGSTCS
SPSQGKGTNCGCITCPGSGTRFCTMTQKWRRSR
AGPPWGTWRAAGTTVL*NTSGLSSWSSPSRAPWR
CMPGPPNPTTNSWPSSPLPTSPTALCWST*Q*R
RGSGSRSSMAPVLASMLWMSTRGTAMTSTSLCT
SRARSRPMPSSSSPTPTAWRCCCATRTRVSTSTR
TGASLRMWCCSGGRCLLLWPTSAPTR*WAGVRK
PLRSALWRRATSTGSSCTNELRGSSSCVSGMTR
CFLPQSALGAAAKFTS*L*TVTAS*TGDGALGWG
CPTLDPALPLQPGFPGRPSFPSLGFCFYWFDFT
GACWERDL*PLMLS*SRDHPLPQHVLFPKLCLS
PASGEGHSFPFPGIEWA*PLPPFLHLRGECLGLE
PLTPLLLTGQGPGPLYLHVRGAGSPLECTRPWG
GSLGPRFLGGHQPLQGQGPFLHFLKAL**FPFP
QTPGNGGGTPPAKTFPPFPTPLSSSSPCPSPVEG
GSREPSLSTPLACICI*CEQQVTLLLPPPSPLL
NVVALDILFVNKDNSTSSH

Frame 2

LAPGR*RLSVGGSVLAPALPLPGLRGRRGGVRP
RGSPMGEKRRRRQWSNRAGA*AAPVPRSPRRPW
ATQPPPAAWTTSTCPPCGQRTRSRDPGDGVLWC
WFSD*PGKEHKRQCPEGGLYRLYLQGDPQGSGPS
PCPQGDPSRHQGAECAADREC*GQASGFWGECS
AGPHRGQTEHFHWDSLLDGSRGHRL**EP*CHL
*LQE*YLVSRNHSHRDGRGSPPSV*HAPHASPLP
HSSEPSAQAQVQEVV*EVH*LH*HMSHQDLPEP
PTHGAATEVSLHPGPAHGAAGPHPA*GPH*PIP
EEAG*ERGDRI*VQRQRGGR*QPWRGRRAKLHHE
RAWRVDSTPGVSPAPAGK*EQLRGFKTAAAAAA
AAAARPRGTHQTPAAPAAAAHRGAEGGAAPRGG
ATAAGAGAAEAAGEGAAAAAGGHAGSAAGGGAAA
GGARAGIQAEAAGGAAAVRTSPEAAAAGACLPQ
VPAAAATAAAASETAAAAAPAWGQEAPVPLWSG
HESR*QTSLGPRGRRENKDEQAAELSLGQEQARQ
HGA*APHPPGLPRAPRTPFPDSSYAEAGGAPGG
TAQEPGGTPGPTEAICSTCTPIPVPAGPAHPKP
GCLPSLP*PRPCHPRTHCHAQCPRSCHPPEFRPH
L*RTWPQPESPSLGPPR*RGPTQGASEDLIYRH
C
P*HQWGRRVPASPGSPCQ*PRPQEERPWLGTL
GQRPSSLSRAPPPGWLTGAEPRGSLLQTGQLPCA
LPWE*SQARRPPLTARPARKL*ASNW*GLCVAE
RADSGRGPSASQEGHGLLVVQRGGGKQ*GRRGG
RRRRASRGEQRYPWGPQRWGYRQRQHHGGPRRRG
DHRDPAPIRGRHHGGPAHP*RGAEPAAC*QQWV
HKPA*RGPAQPLTHREQQRPKPTLEGWEW*LPV
SWAGKGPWQELVHDVCGSRDLPAWRQWGQHPHHS
PSGWRGHSARPAAVRREEGFCGQRESHQHPGPQ
*DP*DPEVQEAIQLRDPLCSPLGGQPAGGHGER
ADVAGPKWAGQGVWTHWAATLPADGCAGGAQPAH
HHLREKEQTAGVLPVLAPEQDSAQ*PRSGEEAG
LDHRGGHGGLRALPCCEIRAD*VPGHRPQELRG
GVCLGPQTLPQIHGLQVLCRPPPPPSAGRPDSRG
GAAAQGHLWLQCWLPCCGCRLGEQL*HLHPCAH
PEPDHAPCHHLPPQHRRHGDAAVLRGRGCLRQH
VRAHH*GCGAAVGGDAYFCGLHLLQPDNGLG*ES
H*DPLCGDGPPRRGLHAQTSSEAQVPV*AE*QG
VFCLSPLWGQQPSLLHDSEP*LHHELVTGPWAG
AVPHWTQLSPCSQASRAAPLSPPWAFAFTGLISL
EPAGNVTSDP*CFRDHVTILFPNMSSSQNCACP
QLLGRDTASPSQELSGPSPSPLFSI*EESAWGL
NPLPHCC*LGRALDPFICTSGEPAPPLNVPDPGG
GHWALDFWGVTSHSRGRDHFFIF*KHFNDSPSP
KLQGMEGGPRQPKHSPHSRPPSPLLAHALPRWR
EGAGSPHSPRPLLASVYSVSSK*PFSSLPPPPSS
M*WPWISCLLIKTIQPAPT

Sequence NM_015716

GGCTGGCTCCGGGGAGATAGCGCCTGTCAGTCGGTGGGTCGGTCCTCGCGCCGGCCCTCCCCCTCCCCGGTCTCCGGGGGAGGCGCGGTGGAGTCCGCCC
CCGGGGTTCTCCGATGGGGGAGAAGCGGCGACGGCGGCAGTGGAGTAACCGAGCCGGAGCGTGAGCGGCCCCGGTGCCCCGTTCCCCACGGAGGCCATGG
GCGACCCAGCCCCCGCCCGCAGCCTGGACGACATCGACCTGTCCGCCCTGCGGACAGAGGACAAGGAGCAGAGACCCTGGTGATGGAGTTCTGTGGTGCT
GGTTCAGTGACTGACCTGGTAAAGAACACAAAAGGCAATGCCCTGAAGGAGGACTGTATCGCCTATATCTGCAGGGAGATCCTCAGGGGTCTGGCCCATC
TCCATGCCCACAAGGTGATCCATCGAGACATCAAGGGGCAGAATGTGCTGCTGACAGAGAATGCTGAGGTCAAGCTAGTGGATTTTGGGGTGAGTGCTCA
GCTGGACCGCACCGTGGGCAGACGGAACACTTTCATTGGGACTCCCTACTGGATGGCTCCAGAGGTCATCGCCTGTGATGAGAACCCTGATGCCACCTAT
GATTACAGGAGTGATATTTGGTCTCTAGGAATCACAGCCATCGAGATGGCAGAGGGAGCCCCCCCTCTGTGTGACATGCACCCCATGCGAGCCCTCTTCC
TCATTCCTCGGAACCCTCCGCCCAGGCTCAAGTCCAAGAAGTGGTCTAAGAAGTTCATTGACTTCATTGACACATGTCTCATCAAGACTTACCTGAGCCG
CCCACCCACGGAGCAGCTACTGAAGTTTCCCTTCATCCGGGACCAGCCCACGGAGCGGCAGGTCCGCATCCAGCTTAAGGACCACATTGACCGATCCCGG
AAGAAGCGGGGTGAGAAAGAGGAGACAGAATATGAGTACAGCGGCAGCGAGGAGGAAGATGACAGCCATGGAGAGGAAGGAGAGCCAAGCTCCATCATGA
ACGTGCCTGGAGAGTCGACTCTACGCCGGGAGTTTCTCCGGCTCCAGCAGGAAAATAAGAGCAACTCAGAGGCTTTAAAACAGCAGCAGCAGCTGCAGCA
GCAGCAGCAGCGAGACCCCGAGGCACACATCAAACACCTGCTGCACCAGCGGCAGCGGCGCATAGAGGAGCAGAAGGAGGAGCGGCGCCGCGTGGAGGAG
CAACAGCGGCGGGAGCGGGAGCAGCGGAAGCTGCAGGAGAAGGAGCAGCAGCGGCGGCTGGAGGACATGCAGGCTCTGCGGCGGGAGGAGGAGCGGCGGC
AGGCGGAGCGCGAGCAGGAATACAAGCGGAAGCAGCTGGAGGAGCAGCGGCAGTCAGAACGTCTCCAGAGGCAGCTGCAGCAGGAGCATGCCTACCTCAA
GTCCCTGCAGCAGCAGCAACAGCAGCAGCAGCTTCAGAAACAGCAGCAGCAGCAGCTCCTGCCTGGGGACAGGAAGCCCCTGTACCATTATGGTCGGGGC
ATGAATCCCGCTGACAAACCAGCCTGGGCCCGAGAGGTAGAAGAGAGAACAAGGATGAACAAGCAGCAGAACTCTCCCTTGGCCAAGAGCAAGCCAGGCA
GCACGGGGCCTGAGCCCCCCATCCCCCAGGCCTCCCCAGGGCCCCCAGGACCCCTTTCCCAGACTCCTCCTATGCAGAGGCCGGTGGAGCCCCAGGAGGG
ACCGCACAAGAGCCTGGTGGCACACCGGGTCCCACTGAAGCCATATGCAGCACCTGTACCCCGATCCCAGTCCCTGCAGGACCAGCCCACCCGAAACCTG
GCTGCCTTCCCAGCCTCCCATGACCCCGACCCTGCCATCCCCGCACCCACTGCCACGCCCAGTGCCCGAGGAGCTGTCATCCGCCAGAATTCAGACCCCA
CCTCTGAAGGACCTGGCCCCAGCCCGAATCCCCCAGCCTGGGTCCGCCCAGATAACGAGGCCCCACCCAAGGTGCCTCAGAGGACCTCATCTATCGCCAC
TGC
CCTTAACACCAGTGGGGCCGGAGGGTCCCGGCCAGCCCAGGCAGTCCGTGCCAGTAACCCCGACCTCAGGAGGAGCGACCCTGGCTGGGAACGCTCG
GACAGCGTCCTTCCAGCCTCTCACGGGCACCTCCCCCAGGCTGGCTCACTGGAGCGGAACCGCGTGGGAGTCTCCTCCAAACCGGACAGCTCCCCTGTGC
TCTCCCCTGGGAATAAAGCCAAGCCCGACGACCACCGCTCACGGCCAGGCCGGCCCGCAGACTTTGTGTTGCTGAAAGAGCGGACTCTGGACGAGGCCCC
TCGGCCTCCCAAGAAGGCCATGGACTACTCGTCGTCCAGCGAGGAGGTGGAAAGCAGTGAGGACGACGAGGAGGAAGGCGAAGGCGGGCCAGCAGAGGGG
AGCAGAGATACCCCTGGGGGCCGCAGCGATGGGGATACAGACAGCGTCAGCACCATGGTGGTCCACGACGTCGAGGAGATCACCGGGACCCAGCCCCCAT
ACGGGGGCGGCACCATGGTGGTCCAGCGCACCCCTGAAGAGGAGCGGAACCTGCTGCATGCTGACAGCAATGGGTACACAAACCTGCCTGACGTGGTCCA
GCCCAGCCACTCACCCACCGAGAACAGCAAAGGCCAAAGCCCACCCTCGAAGGATGGGAGTGGTGACTACCAGTCTCGTGGGCTGGTAAAGGCCCCTGGC
AAGAGCTCGTTCACGATGTTTGTGGATCTAGGGATCTACCAGCCTGGAGGCAGTGGGGACAGCATCCCCATCACAGCCCTAGTGGGTGGAGAGGGCACTC
GGCTCGACCAGCTGCAGTACGACGTGAGGAAGGGTTCTGTGGTCAACGTGAATCCCACCAACACCCGGGCCCACAGTGAGACCCCTGAGATCCGGAAGTA
CAAGAAGCGATTCAACTCCGAGATCCTCTGTGCAGCCCTTTGGGGGGTCAACCTGCTGGTGGGCACGGAGAACGGGCTGATGTTGCTGGACCGAAGTGGG
CAGGGCAAGGTGTATGGACTCATTGGGCGGCGACGCTTCCAGCAGATGGATGTGCTGGAGGGGCTCAACCTGCTCATCACCATCTCAGGGAAAAGGAACA
AACTGCGGGTGTATTACCTGTCCTGGCTCCGGAACAAGATTCTGCACAATGACCCAGAAGTGGAGAAGAAGCAGGGCTGGACCACCGTGGGGGACATGGA
GGGCTGCGGGCACTACCGTGTTGTGAAATACGAGCGGATTAAGTTCCTGGTCATCGCCCTCAAGAGCTCCGTGGAGGTGTATGCCTGGGCCCCCAAACCC
TACCACAAATTCATGGCCTTCAAGTCCTTTGCCGACCTCCCCCACCGCCCTCTGCTGGTCGACCTGACAGTAGAGGAGGGGCAGCGGCTCAAGGTCATCT
ATGGCTCCAGTGCTGGCTTCCATGCTGTGGATGTCGACTCGGGGAACAGCTATGACATCTACATCCCTGTGCACATCCAGAGCCAGATCACGCCCCATGC
CATCATCTTCCTCCCCAACACCGACGGCATGGAGATGCTGCTGTGCTACGAGGACGAGGGTGTCTACGTCAACACGTACGGGCGCATCATTAAGGATGTG
GTGCTGCAGTGGGGGGAGATGCCTACTTCTGTGGCCTACATCTGCTCCAACCAGATAATGGGCTGGGGTGAGAAAGCCATTGAGATCCGCTCTGTGGAGA
CGGGCCACCTCGACGGGGTCTTCATGCACAAACGAGCTCAGAGGCTCAAGTTCCTGTGTGAGCGGAATGACAAGGTGTTTTTTGCCTCAGTCCGCTCTGG
GGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCT
CCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTC
TGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCTTCCCAAAACTGTGCCTGTCCCCAGCTTCTGGGGAGGGACACAGCT
TCCCCTTCCCAGGAATTGAGTGGGCCTAGCCCCTCCCCCCTTTTCTCCATTTGAGAGGAGAGTGCTTGGGGCTTGAACCCCTTACCCCACTGCTGCTGAC
TGGGCAGGGCCCTGGACCCCTTTATTTGCACGTCAGGGGAGCCGGCTCCCCCCTTGAATGTACCAGACCCTGGGGGGGGTCACTGGGCCCTAGATTTTTG
GGGGGTCACCAGCCACTCCAGGGGCAGGGACCATTTCTTCATTTTCTGAAAGCACTTTAATGATTCCCCTTCCCCCAAACTCCAGGGAATGGAGGGGGGA
CCCCGCCAGCCAAAACATTCCCCCCATTCCCGACCCCCCTCTCCTCTTCTAGCCCATGCCCTTCCCCGGTGGAGGGAGGGAGCAGGGAGCCCTCACTCTC
CACGCCCCTTGCTTGCATCTGTATATAGTGTGAGCAGCAAGTAACCCTTCTCCTCCCTCCCCCCTCCCCCCTCCTCAATGTAGTGGCCTTGGATATCCTG
TTTGTTAATAAAGACAATTCAACCAGCTCCCACCA
  • refseq_MINK1.F3 (forward primer)
  • refseq_MINK1.R3 (reverse primer)
  • Single exon skipping

Frame 0

GWLRGDSACQSVGRSSRRPSPSPVSGGGAVESA
PGVLRWGRSGDGGSGVTEPERERPRCPVPHGGHG
RPSPRPQPGRHRPVRPADRGQGAETLVMEFCGA
GSVTDLVKNTKGNALKEDCIAYICREILRGLAH
LHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQ
LDRTVGRRNTFIGTPYWMAPEVIACDENPDATY
DYRSDIWSLGITAIEMAEGAPPLCDMHPMRALF
LIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSR
PPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSR
KKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIM
NVPGESTLRREFLRLQQENKSNSEALKQQQQLQQ
QQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEE
QQRREREQRKLQEKEQQRRLEDMQALRREEERR
QAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLK
SLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRG
MNPADKPAWAREVEERTRMNKQQNSPLAKSKPG
STGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEG
PHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNL
AAFPASHDPDPAIPAPTATPSARGAVIRQNSDP
TSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIAT
A
LNTSGAGGSRPAQAVRASNPDLRRSDPGWERS
DSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV
LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAP
RPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEG
SRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPP
YGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQ
PSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPG
KSSFTMFVDLGIYQPGGSGDSIPITALVGGEGT
RLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKY
KKRFNSEILCAALWGVNLLVGTENGLMLLDRSG
QGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN
KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDME
GCGHYRVVKYERIKFLVIALKSSVEVYAWAPKP
YHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVI
YGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHA
IIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDV
VLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVE
TGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSG
GSSQVYFMTLNRNCIMNW*RGPGLGLSHTGPSS
PPAARLPGPPLFPLPGLLLLLV*FHWSLLGT*P
LTPDAFVIT*PSSSPTCPLPKTVPVPSFWGGTQL
PLPRN*VGLAPPPFSPFERRVLGA*TPYPTAAD
WAGPWTPLFARQGSRLPP*MYQTLGGVTGP*IF
GGSPATPGAGTISSFSESTLMIPLPPNSREWRGD
PASQNIPPIPDPPLLF*PMPFPGGGREQGALTL
HAPCLHLYIV*AASNPSPPSPLPPPQCSGLGYP
VC**RQFNQLPP

Frame 1

AGSGEIAPVSRWVGPRAGPPPPRSPGEARWSPP
PGFSDGGEAATAAVE*PSRSVSGPGAPFPTEAM
GDPAPARSLDDIDLSALRTEDKEQRPW*WSSVVL
VQ*LTW*RTQKAMP*RRTVSPISAGRSSGVWPI
SMPTR*SIETSRGRMCC*QRMLRSS*WILG*VL
SWTAPWADGTLSLGLPTGWLQRSSPVMRTLMPPM
ITGVIFGL*ESQPSRWQREPPLCVTCTPCEPSS
SFLGTLRPGSSPRSGLRSSLTSLTHVSSRLT*A
AHPRSSY*SFPSSGTSPRSGRSASSLRTTLTDPG
RSGVRKRRQNMSTAAARRKMTAMERKESQAPS*
TCLESRLYAGSFSGSSRKIRATQRL*NSSSSCS
SSSSETPRHTSNTCCTSGSGA*RSRRRSGAAWRS
NSGGSGSSGSCRRRSSSGGWRTCRLCGGRRSGG
RRSASRNTSGSSWRSSGSQNVSRGSCSRSMPTS
SPCSSSNSSSSFRNSSSSSSCLGTGSPCTIMVGA
*IPLTNQPGPER*KREQG*TSSRTLPWPRASQA
ARGLSPPSPRPPQGPQDPFPRLLLCRGRWSPRR
DRTRAWWHTGSH*SHMQHLYPDPSPCRTSPPETW
LPSQPPMTPTLPSPHPLPRPVPEELSSARIQTP
PLKDLAPARIPQPGSAQITRPHPRCLRGPHLSP
L
PLTPVGPEGPGQPRQSVPVTPTSGGATLAGNAR
TASFQPLTGTSPRLAHWSGTAWESPPNRTAPLC
SPLGIKPSPTTTAHGQAGPQTLCC*KSGLWTRP
LGLPRRPWTTRRPARRWKAVRTTRRKAKAGQQRG
AEIPLGAAAMGIQTASAPWWSTTSRRSPGPSPH
TGAAPWWSSAPLKRSGTCCMLTAMGTQTCLTWS
SPATHPPRTAKAKAHPRRMGVVTTSLVGW*RPLA
RARSRCLWI*GSTSLEAVGTASPSQP*WVERAL
GSTSCSTT*GRVLWST*IPPTPGPTVRPLRSGS
TRSDSTPRSSVQPFGGSTCWWARRTG*CCWTEVG
RARCMDSLGGDASSRWMCWRGSTCSSPSQGKGT
NCGCITCPGSGTRFCTMTQKWRRSRAGPPWGTW
RAAGTTVL*NTSGLSSWSSPSRAPWRCMPGPPNP
TTNSWPSSPLPTSPTALCWST*Q*RRGSGSRSS
MAPVLASMLWMSTRGTAMTSTSLCTSRARSRPM
PSSSSPTPTAWRCCCATRTRVSTSTRTGASLRMW
CCSGGRCLLLWPTSAPTR*WAGVRKPLRSALWR
RATSTGSSCTNELRGSSSCVSGMTRCFLPQSAL
GAAAKFTS*L*TVTAS*TGDGALGWGCPTLDPAL
PLQPGFPGRPSFPSLGFCFYWFDFTGACWERDL
*PLMLS*SRDHPLPQHVLFPKLCLSPASGEGHS
FPFPGIEWA*PLPPFLHLRGECLGLEPLTPLLLT
GQGPGPLYLHVRGAGSPLECTRPWGGSLGPRFL
GGHQPLQGQGPFLHFLKAL**FPFPQTPGNGGG
TPPAKTFPPFPTPLSSSSPCPSPVEGGSREPSLS
TPLACICI*CEQQVTLLLPPPSPLLNVVALDIL
FVNKDNSTSSH

Frame 2

LAPGR*RLSVGGSVLAPALPLPGLRGRRGGVRP
RGSPMGEKRRRRQWSNRAGA*AAPVPRSPRRPW
ATQPPPAAWTTSTCPPCGQRTRSRDPGDGVLWC
WFSD*PGKEHKRQCPEGGLYRLYLQGDPQGSGPS
PCPQGDPSRHQGAECAADREC*GQASGFWGECS
AGPHRGQTEHFHWDSLLDGSRGHRL**EP*CHL
*LQE*YLVSRNHSHRDGRGSPPSV*HAPHASPLP
HSSEPSAQAQVQEVV*EVH*LH*HMSHQDLPEP
PTHGAATEVSLHPGPAHGAAGPHPA*GPH*PIP
EEAG*ERGDRI*VQRQRGGR*QPWRGRRAKLHHE
RAWRVDSTPGVSPAPAGK*EQLRGFKTAAAAAA
AAAARPRGTHQTPAAPAAAAHRGAEGGAAPRGG
ATAAGAGAAEAAGEGAAAAAGGHAGSAAGGGAAA
GGARAGIQAEAAGGAAAVRTSPEAAAAGACLPQ
VPAAAATAAAASETAAAAAPAWGQEAPVPLWSG
HESR*QTSLGPRGRRENKDEQAAELSLGQEQARQ
HGA*APHPPGLPRAPRTPFPDSSYAEAGGAPGG
TAQEPGGTPGPTEAICSTCTPIPVPAGPAHPKP
GCLPSLP*PRPCHPRTHCHAQCPRSCHPPEFRPH
L*RTWPQPESPSLGPPR*RGPTQGASEDLIYRH
C
P*HQWGRRVPASPGSPCQ*PRPQEERPWLGTL
GQRPSSLSRAPPPGWLTGAEPRGSLLQTGQLPCA
LPWE*SQARRPPLTARPARRLCVAERADSGRGP
SASQEGHGLLVVQRGGGKQ*GRRGGRRRRASRG
EQRYPWGPQRWGYRQRQHHGGPRRRGDHRDPAPI
RGRHHGGPAHP*RGAEPAAC*QQWVHKPA*RGP
AQPLTHREQQRPKPTLEGWEW*LPVSWAGKGPW
QELVHDVCGSRDLPAWRQWGQHPHHSPSGWRGHS
ARPAAVRREEGFCGQRESHQHPGPQ*DP*DPEV
QEAIQLRDPLCSPLGGQPAGGHGERADVAGPKW
AGQGVWTHWAATLPADGCAGGAQPAHHHLREKEQ
TAGVLPVLAPEQDSAQ*PRSGEEAGLDHRGGHG
GLRALPCCEIRAD*VPGHRPQELRGGVCLGPQT
LPQIHGLQVLCRPPPPPSAGRPDSRGGAAAQGHL
WLQCWLPCCGCRLGEQL*HLHPCAHPEPDHAPC
HHLPPQHRRHGDAAVLRGRGCLRQHVRAHH*GC
GAAVGGDAYFCGLHLLQPDNGLG*ESH*DPLCGD
GPPRRGLHAQTSSEAQVPV*AE*QGVFCLSPLW
GQQPSLLHDSEP*LHHELVTGPWAGAVPHWTQL
SPCSQASRAAPLSPPWAFAFTGLISLEPAGNVTS
DP*CFRDHVTILFPNMSSSQNCACPQLLGRDTA
SPSQELSGPSPSPLFSI*EESAWGLNPLPHCC*
LGRALDPFICTSGEPAPPLNVPDPGGGHWALDFW
GVTSHSRGRDHFFIF*KHFNDSPSPKLQGMEGG
PRQPKHSPHSRPPSPLLAHALPRWREGAGSPHS
PRPLLASVYSVSSK*PFSSLPPPPSSM*WPWISC
LLIKTIQPAPT

Sequence NM_001024937

GGCTGGCTCCGGGGAGATAGCGCCTGTCAGTCGGTGGGTCGGTCCTCGCGCCGGCCCTCCCCCTCCCCGGTCTCCGGGGGAGGCGCGGTGGAGTCCGCCC
CCGGGGTTCTCCGATGGGGGAGAAGCGGCGACGGCGGCAGTGGAGTAACCGAGCCGGAGCGTGAGCGGCCCCGGTGCCCCGTTCCCCACGGAGGCCATGG
GCGACCCAGCCCCCGCCCGCAGCCTGGACGACATCGACCTGTCCGCCCTGCGGACAGAGGACAAGGAGCAGAGACCCTGGTGATGGAGTTCTGTGGTGCT
GGTTCAGTGACTGACCTGGTAAAGAACACAAAAGGCAATGCCCTGAAGGAGGACTGTATCGCCTATATCTGCAGGGAGATCCTCAGGGGTCTGGCCCATC
TCCATGCCCACAAGGTGATCCATCGAGACATCAAGGGGCAGAATGTGCTGCTGACAGAGAATGCTGAGGTCAAGCTAGTGGATTTTGGGGTGAGTGCTCA
GCTGGACCGCACCGTGGGCAGACGGAACACTTTCATTGGGACTCCCTACTGGATGGCTCCAGAGGTCATCGCCTGTGATGAGAACCCTGATGCCACCTAT
GATTACAGGAGTGATATTTGGTCTCTAGGAATCACAGCCATCGAGATGGCAGAGGGAGCCCCCCCTCTGTGTGACATGCACCCCATGCGAGCCCTCTTCC
TCATTCCTCGGAACCCTCCGCCCAGGCTCAAGTCCAAGAAGTGGTCTAAGAAGTTCATTGACTTCATTGACACATGTCTCATCAAGACTTACCTGAGCCG
CCCACCCACGGAGCAGCTACTGAAGTTTCCCTTCATCCGGGACCAGCCCACGGAGCGGCAGGTCCGCATCCAGCTTAAGGACCACATTGACCGATCCCGG
AAGAAGCGGGGTGAGAAAGAGGAGACAGAATATGAGTACAGCGGCAGCGAGGAGGAAGATGACAGCCATGGAGAGGAAGGAGAGCCAAGCTCCATCATGA
ACGTGCCTGGAGAGTCGACTCTACGCCGGGAGTTTCTCCGGCTCCAGCAGGAAAATAAGAGCAACTCAGAGGCTTTAAAACAGCAGCAGCAGCTGCAGCA
GCAGCAGCAGCGAGACCCCGAGGCACACATCAAACACCTGCTGCACCAGCGGCAGCGGCGCATAGAGGAGCAGAAGGAGGAGCGGCGCCGCGTGGAGGAG
CAACAGCGGCGGGAGCGGGAGCAGCGGAAGCTGCAGGAGAAGGAGCAGCAGCGGCGGCTGGAGGACATGCAGGCTCTGCGGCGGGAGGAGGAGCGGCGGC
AGGCGGAGCGCGAGCAGGAATACAAGCGGAAGCAGCTGGAGGAGCAGCGGCAGTCAGAACGTCTCCAGAGGCAGCTGCAGCAGGAGCATGCCTACCTCAA
GTCCCTGCAGCAGCAGCAACAGCAGCAGCAGCTTCAGAAACAGCAGCAGCAGCAGCTCCTGCCTGGGGACAGGAAGCCCCTGTACCATTATGGTCGGGGC
ATGAATCCCGCTGACAAACCAGCCTGGGCCCGAGAGGTAGAAGAGAGAACAAGGATGAACAAGCAGCAGAACTCTCCCTTGGCCAAGAGCAAGCCAGGCA
GCACGGGGCCTGAGCCCCCCATCCCCCAGGCCTCCCCAGGGCCCCCAGGACCCCTTTCCCAGACTCCTCCTATGCAGAGGCCGGTGGAGCCCCAGGAGGG
ACCGCACAAGTCCCTGCAGGACCAGCCCACCCGAAACCTGGCTGCCTTCCCAGCCTCCCATGACCCCGACCCTGCCATCCCCGCACCCACTGCCACGCCC
AGTGCCCGAGGAGCTGTCATCCGCCAGAATTCAGACCCCACCTCTGAAGGACCTGGCCCCAGCCCGAATCCCCCAGCCTGGGTCCGCCCAGATAACGAGG
CCCCACCCAAGGTGCCTCAGAGGACCTCATCTATCGCCACTGCCCTTAACACCAGTGGGGCCGGAGGGTCCCGGCCAGCCCAGGCAGTCCGTGCCAGACC
TCGCAGCAACTCCGCCTGGCAAATCTATCTGCAAAGGCGGGCAGAGCGGGGCACCCCAAAGCCTCCAGGGCCCCCTGCTCAGCCCCCTGGCCCGCCCAAC
GCCTCTAG
TAACCCCGACCTCAGGAGGAGCGACCCTGGCTGGGAACGCTCGGACAGCGTCCTTCCAGCCTCTCACGGGCACCTCCCCCAGGCTGGCTCAC
TGGAGCGGAACCGCGTGGGAGTCTCCTCCAAACCGGACAGCTCCCCTGTGCTCTCCCCTGGGAATAAAGCCAAGCCCGACGACCACCGCTCACGGCCAGG
CCGGCCCGCAGACTTTGTGTTGCTGAAAGAGCGGACTCTGGACGAGGCCCCTCGGCCTCCCAAGAAGGCCATGGACTACTCGTCGTCCAGCGAGGAGGTG
GAAAGCAGTGAGGACGACGAGGAGGAAGGCGAAGGCGGGCCAGCAGAGGGGAGCAGAGATACCCCTGGGGGCCGCAGCGATGGGGATACAGACAGCGTCA
GCACCATGGTGGTCCACGACGTCGAGGAGATCACCGGGACCCAGCCCCCATACGGGGGCGGCACCATGGTGGTCCAGCGCACCCCTGAAGAGGAGCGGAA
CCTGCTGCATGCTGACAGCAATGGGTACACAAACCTGCCTGACGTGGTCCAGCCCAGCCACTCACCCACCGAGAACAGCAAAGGCCAAAGCCCACCCTCG
AAGGATGGGAGTGGTGACTACCAGTCTCGTGGGCTGGTAAAGGCCCCTGGCAAGAGCTCGTTCACGATGTTTGTGGATCTAGGGATCTACCAGCCTGGAG
GCAGTGGGGACAGCATCCCCATCACAGCCCTAGTGGGTGGAGAGGGCACTCGGCTCGACCAGCTGCAGTACGACGTGAGGAAGGGTTCTGTGGTCAACGT
GAATCCCACCAACACCCGGGCCCACAGTGAGACCCCTGAGATCCGGAAGTACAAGAAGCGATTCAACTCCGAGATCCTCTGTGCAGCCCTTTGGGGGGTC
AACCTGCTGGTGGGCACGGAGAACGGGCTGATGTTGCTGGACCGAAGTGGGCAGGGCAAGGTGTATGGACTCATTGGGCGGCGACGCTTCCAGCAGATGG
ATGTGCTGGAGGGGCTCAACCTGCTCATCACCATCTCAGGGAAAAGGAACAAACTGCGGGTGTATTACCTGTCCTGGCTCCGGAACAAGATTCTGCACAA
TGACCCAGAAGTGGAGAAGAAGCAGGGCTGGACCACCGTGGGGGACATGGAGGGCTGCGGGCACTACCGTGTTGTGAAATACGAGCGGATTAAGTTCCTG
GTCATCGCCCTCAAGAGCTCCGTGGAGGTGTATGCCTGGGCCCCCAAACCCTACCACAAATTCATGGCCTTCAAGTCCTTTGCCGACCTCCCCCACCGCC
CTCTGCTGGTCGACCTGACAGTAGAGGAGGGGCAGCGGCTCAAGGTCATCTATGGCTCCAGTGCTGGCTTCCATGCTGTGGATGTCGACTCGGGGAACAG
CTATGACATCTACATCCCTGTGCACATCCAGAGCCAGATCACGCCCCATGCCATCATCTTCCTCCCCAACACCGACGGCATGGAGATGCTGCTGTGCTAC
GAGGACGAGGGTGTCTACGTCAACACGTACGGGCGCATCATTAAGGATGTGGTGCTGCAGTGGGGGGAGATGCCTACTTCTGTGGCCTACATCTGCTCCA
ACCAGATAATGGGCTGGGGTGAGAAAGCCATTGAGATCCGCTCTGTGGAGACGGGCCACCTCGACGGGGTCTTCATGCACAAACGAGCTCAGAGGCTCAA
GTTCCTGTGTGAGCGGAATGACAAGGTGTTTTTTGCCTCAGTCCGCTCTGGGGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATG
AACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGC
TTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATG
TCCTCTTCCCAAAACTGTGCCTGTCCCCAGCTTCTGGGGAGGGACACAGCTTCCCCTTCCCAGGAATTGAGTGGGCCTAGCCCCTCCCCCCTTTTCTCCA
TTTGAGAGGAGAGTGCTTGGGGCTTGAACCCCTTACCCCACTGCTGCTGACTGGGCAGGGCCCTGGACCCCTTTATTTGCACGTCAGGGGAGCCGGCTCC
CCCCTTGAATGTACCAGACCCTGGGGGGGGTCACTGGGCCCTAGATTTTTGGGGGGTCACCAGCCACTCCAGGGGCAGGGACCATTTCTTCATTTTCTGA
AAGCACTTTAATGATTCCCCTTCCCCCAAACTCCAGGGAATGGAGGGGGGACCCCGCCAGCCAAAACATTCCCCCCATTCCCGACCCCCCTCTCCTCTTC
TAGCCCATGCCCTTCCCCGGTGGAGGGAGGGAGCAGGGAGCCCTCACTCTCCACGCCCCTTGCTTGCATCTGTATATAGTGTGAGCAGCAAGTAACCCTT
CTCCTCCCTCCCCCCTCCCCCCTCCTCAATGTAGTGGCCTTGGATATCCTGTTTGTTAATAAAGACAATTCAACCAGCTCCCACCA
  • refseq_MINK1.F3 (forward primer)
  • refseq_MINK1.R3 (reverse primer)
  • Single exon skipping

Frame 0

GWLRGDSACQSVGRSSRRPSPSPVSGGGAVESA
PGVLRWGRSGDGGSGVTEPERERPRCPVPHGGHG
RPSPRPQPGRHRPVRPADRGQGAETLVMEFCGA
GSVTDLVKNTKGNALKEDCIAYICREILRGLAH
LHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQ
LDRTVGRRNTFIGTPYWMAPEVIACDENPDATY
DYRSDIWSLGITAIEMAEGAPPLCDMHPMRALF
LIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSR
PPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSR
KKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIM
NVPGESTLRREFLRLQQENKSNSEALKQQQQLQQ
QQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEE
QQRREREQRKLQEKEQQRRLEDMQALRREEERR
QAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLK
SLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRG
MNPADKPAWAREVEERTRMNKQQNSPLAKSKPG
STGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEG
PHKSLQDQPTRNLAAFPASHDPDPAIPAPTATP
SARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNE
APPKVPQRTSSIATALNTSGAGGSRPAQAVRARP
RSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPN
ASS
NPDLRRSDPGWERSDSVLPASHGHLPQAGS
LERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPG
RPADFVLLKERTLDEAPRPPKKAMDYSSSSEEV
ESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSV
STMVVHDVEEITGTQPPYGGGTMVVQRTPEEERN
LLHADSNGYTNLPDVVQPSHSPTENSKGQSPPS
KDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPG
GSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNV
NPTNTRAHSETPEIRKYKKRFNSEILCAALWGV
NLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQM
DVLEGLNLLITISGKRNKLRVYYLSWLRNKILHN
DPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFL
VIALKSSVEVYAWAPKPYHKFMAFKSFADLPHR
PLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNS
YDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCY
EDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICS
NQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLK
FLCERNDKVFFASVRSGGSSQVYFMTLNRNCIM
NW*RGPGLGLSHTGPSSPPAARLPGPPLFPLPG
LLLLLV*FHWSLLGT*PLTPDAFVIT*PSSSPTC
PLPKTVPVPSFWGGTQLPLPRN*VGLAPPPFSP
FERRVLGA*TPYPTAADWAGPWTPLFARQGSRL
PP*MYQTLGGVTGP*IFGGSPATPGAGTISSFSE
STLMIPLPPNSREWRGDPASQNIPPIPDPPLLF
*PMPFPGGGREQGALTLHAPCLHLYIV*AASNP
SPPSPLPPPQCSGLGYPVC**RQFNQLPP

Frame 1

AGSGEIAPVSRWVGPRAGPPPPRSPGEARWSPP
PGFSDGGEAATAAVE*PSRSVSGPGAPFPTEAM
GDPAPARSLDDIDLSALRTEDKEQRPW*WSSVVL
VQ*LTW*RTQKAMP*RRTVSPISAGRSSGVWPI
SMPTR*SIETSRGRMCC*QRMLRSS*WILG*VL
SWTAPWADGTLSLGLPTGWLQRSSPVMRTLMPPM
ITGVIFGL*ESQPSRWQREPPLCVTCTPCEPSS
SFLGTLRPGSSPRSGLRSSLTSLTHVSSRLT*A
AHPRSSY*SFPSSGTSPRSGRSASSLRTTLTDPG
RSGVRKRRQNMSTAAARRKMTAMERKESQAPS*
TCLESRLYAGSFSGSSRKIRATQRL*NSSSSCS
SSSSETPRHTSNTCCTSGSGA*RSRRRSGAAWRS
NSGGSGSSGSCRRRSSSGGWRTCRLCGGRRSGG
RRSASRNTSGSSWRSSGSQNVSRGSCSRSMPTS
SPCSSSNSSSSFRNSSSSSSCLGTGSPCTIMVGA
*IPLTNQPGPER*KREQG*TSSRTLPWPRASQA
ARGLSPPSPRPPQGPQDPFPRLLLCRGRWSPRR
DRTSPCRTSPPETWLPSQPPMTPTLPSPHPLPRP
VPEELSSARIQTPPLKDLAPARIPQPGSAQITR
PHPRCLRGPHLSPLPLTPVGPEGPGQPRQSVPD
LAATPPGKSICKGGQSGAPQSLQGPLLSPLARPT
PL
VTPTSGGATLAGNARTASFQPLTGTSPRLAH
WSGTAWESPPNRTAPLCSPLGIKPSPTTTAHGQ
AGPQTLCC*KSGLWTRPLGLPRRPWTTRRPARRW
KAVRTTRRKAKAGQQRGAEIPLGAAAMGIQTAS
APWWSTTSRRSPGPSPHTGAAPWWSSAPLKRSG
TCCMLTAMGTQTCLTWSSPATHPPRTAKAKAHPR
RMGVVTTSLVGW*RPLARARSRCLWI*GSTSLE
AVGTASPSQP*WVERALGSTSCSTT*GRVLWST
*IPPTPGPTVRPLRSGSTRSDSTPRSSVQPFGGS
TCWWARRTG*CCWTEVGRARCMDSLGGDASSRW
MCWRGSTCSSPSQGKGTNCGCITCPGSGTRFCT
MTQKWRRSRAGPPWGTWRAAGTTVL*NTSGLSSW
SSPSRAPWRCMPGPPNPTTNSWPSSPLPTSPTA
LCWST*Q*RRGSGSRSSMAPVLASMLWMSTRGT
AMTSTSLCTSRARSRPMPSSSSPTPTAWRCCCAT
RTRVSTSTRTGASLRMWCCSGGRCLLLWPTSAP
TR*WAGVRKPLRSALWRRATSTGSSCTNELRGS
SSCVSGMTRCFLPQSALGAAAKFTS*L*TVTAS*
TGDGALGWGCPTLDPALPLQPGFPGRPSFPSLG
FCFYWFDFTGACWERDL*PLMLS*SRDHPLPQH
VLFPKLCLSPASGEGHSFPFPGIEWA*PLPPFLH
LRGECLGLEPLTPLLLTGQGPGPLYLHVRGAGS
PLECTRPWGGSLGPRFLGGHQPLQGQGPFLHFL
KAL**FPFPQTPGNGGGTPPAKTFPPFPTPLSSS
SPCPSPVEGGSREPSLSTPLACICI*CEQQVTL
LLPPPSPLLNVVALDILFVNKDNSTSSH

Frame 2

LAPGR*RLSVGGSVLAPALPLPGLRGRRGGVRP
RGSPMGEKRRRRQWSNRAGA*AAPVPRSPRRPW
ATQPPPAAWTTSTCPPCGQRTRSRDPGDGVLWC
WFSD*PGKEHKRQCPEGGLYRLYLQGDPQGSGPS
PCPQGDPSRHQGAECAADREC*GQASGFWGECS
AGPHRGQTEHFHWDSLLDGSRGHRL**EP*CHL
*LQE*YLVSRNHSHRDGRGSPPSV*HAPHASPLP
HSSEPSAQAQVQEVV*EVH*LH*HMSHQDLPEP
PTHGAATEVSLHPGPAHGAAGPHPA*GPH*PIP
EEAG*ERGDRI*VQRQRGGR*QPWRGRRAKLHHE
RAWRVDSTPGVSPAPAGK*EQLRGFKTAAAAAA
AAAARPRGTHQTPAAPAAAAHRGAEGGAAPRGG
ATAAGAGAAEAAGEGAAAAAGGHAGSAAGGGAAA
GGARAGIQAEAAGGAAAVRTSPEAAAAGACLPQ
VPAAAATAAAASETAAAAAPAWGQEAPVPLWSG
HESR*QTSLGPRGRRENKDEQAAELSLGQEQARQ
HGA*APHPPGLPRAPRTPFPDSSYAEAGGAPGG
TAQVPAGPAHPKPGCLPSLP*PRPCHPRTHCHA
QCPRSCHPPEFRPHL*RTWPQPESPSLGPPR*RG
PTQGASEDLIYRHCP*HQWGRRVPASPGSPCQT
SQQLRLANLSAKAGRAGHPKASRAPCSAPWPAQ
RL*
*PRPQEERPWLGTLGQRPSSLSRAPPPGWLT
GAEPRGSLLQTGQLPCALPWE*SQARRPPLTAR
PARRLCVAERADSGRGPSASQEGHGLLVVQRGG
GKQ*GRRGGRRRRASRGEQRYPWGPQRWGYRQRQ
HHGGPRRRGDHRDPAPIRGRHHGGPAHP*RGAE
PAAC*QQWVHKPA*RGPAQPLTHREQQRPKPTL
EGWEW*LPVSWAGKGPWQELVHDVCGSRDLPAWR
QWGQHPHHSPSGWRGHSARPAAVRREEGFCGQR
ESHQHPGPQ*DP*DPEVQEAIQLRDPLCSPLGG
QPAGGHGERADVAGPKWAGQGVWTHWAATLPADG
CAGGAQPAHHHLREKEQTAGVLPVLAPEQDSAQ
*PRSGEEAGLDHRGGHGGLRALPCCEIRAD*VP
GHRPQELRGGVCLGPQTLPQIHGLQVLCRPPPPP
SAGRPDSRGGAAAQGHLWLQCWLPCCGCRLGEQ
L*HLHPCAHPEPDHAPCHHLPPQHRRHGDAAVL
RGRGCLRQHVRAHH*GCGAAVGGDAYFCGLHLLQ
PDNGLG*ESH*DPLCGDGPPRRGLHAQTSSEAQ
VPV*AE*QGVFCLSPLWGQQPSLLHDSEP*LHH
ELVTGPWAGAVPHWTQLSPCSQASRAAPLSPPWA
FAFTGLISLEPAGNVTSDP*CFRDHVTILFPNM
SSSQNCACPQLLGRDTASPSQELSGPSPSPLFS
I*EESAWGLNPLPHCC*LGRALDPFICTSGEPAP
PLNVPDPGGGHWALDFWGVTSHSRGRDHFFIF*
KHFNDSPSPKLQGMEGGPRQPKHSPHSRPPSPL
LAHALPRWREGAGSPHSPRPLLASVYSVSSK*PF
SSLPPPPSSM*WPWISCLLIKTIQPAPT

Sequence NM_153827

GGCTGGCTCCGGGGAGATAGCGCCTGTCAGTCGGTGGGTCGGTCCTCGCGCCGGCCCTCCCCCTCCCCGGTCTCCGGGGGAGGCGCGGTGGAGTCCGCCC
CCGGGGTTCTCCGATGGGGGAGAAGCGGCGACGGCGGCAGTGGAGTAACCGAGCCGGAGCGTGAGCGGCCCCGGTGCCCCGTTCCCCACGGAGGCCATGG
GCGACCCAGCCCCCGCCCGCAGCCTGGACGACATCGACCTGTCCGCCCTGCGGACAGAGGACAAGGAGCAGAGACCCTGGTGATGGAGTTCTGTGGTGCT
GGTTCAGTGACTGACCTGGTAAAGAACACAAAAGGCAATGCCCTGAAGGAGGACTGTATCGCCTATATCTGCAGGGAGATCCTCAGGGGTCTGGCCCATC
TCCATGCCCACAAGGTGATCCATCGAGACATCAAGGGGCAGAATGTGCTGCTGACAGAGAATGCTGAGGTCAAGCTAGTGGATTTTGGGGTGAGTGCTCA
GCTGGACCGCACCGTGGGCAGACGGAACACTTTCATTGGGACTCCCTACTGGATGGCTCCAGAGGTCATCGCCTGTGATGAGAACCCTGATGCCACCTAT
GATTACAGGAGTGATATTTGGTCTCTAGGAATCACAGCCATCGAGATGGCAGAGGGAGCCCCCCCTCTGTGTGACATGCACCCCATGCGAGCCCTCTTCC
TCATTCCTCGGAACCCTCCGCCCAGGCTCAAGTCCAAGAAGTGGTCTAAGAAGTTCATTGACTTCATTGACACATGTCTCATCAAGACTTACCTGAGCCG
CCCACCCACGGAGCAGCTACTGAAGTTTCCCTTCATCCGGGACCAGCCCACGGAGCGGCAGGTCCGCATCCAGCTTAAGGACCACATTGACCGATCCCGG
AAGAAGCGGGGTGAGAAAGAGGAGACAGAATATGAGTACAGCGGCAGCGAGGAGGAAGATGACAGCCATGGAGAGGAAGGAGAGCCAAGCTCCATCATGA
ACGTGCCTGGAGAGTCGACTCTACGCCGGGAGTTTCTCCGGCTCCAGCAGGAAAATAAGAGCAACTCAGAGGCTTTAAAACAGCAGCAGCAGCTGCAGCA
GCAGCAGCAGCGAGACCCCGAGGCACACATCAAACACCTGCTGCACCAGCGGCAGCGGCGCATAGAGGAGCAGAAGGAGGAGCGGCGCCGCGTGGAGGAG
CAACAGCGGCGGGAGCGGGAGCAGCGGAAGCTGCAGGAGAAGGAGCAGCAGCGGCGGCTGGAGGACATGCAGGCTCTGCGGCGGGAGGAGGAGCGGCGGC
AGGCGGAGCGCGAGCAGGAATACAAGCGGAAGCAGCTGGAGGAGCAGCGGCAGTCAGAACGTCTCCAGAGGCAGCTGCAGCAGGAGCATGCCTACCTCAA
GTCCCTGCAGCAGCAGCAACAGCAGCAGCAGCTTCAGAAACAGCAGCAGCAGCAGCTCCTGCCTGGGGACAGGAAGCCCCTGTACCATTATGGTCGGGGC
ATGAATCCCGCTGACAAACCAGCCTGGGCCCGAGAGGTAGAAGAGAGAACAAGGATGAACAAGCAGCAGAACTCTCCCTTGGCCAAGAGCAAGCCAGGCA
GCACGGGGCCTGAGCCCCCCATCCCCCAGGCCTCCCCAGGGCCCCCAGGACCCCTTTCCCAGACTCCTCCTATGCAGAGGCCGGTGGAGCCCCAGGAGGG
ACCGCACAAGAGCCTGGTGGCACACCGGGTCCCACTGAAGCCATATGCAGCACCTGTACCCCGATCCCAGTCCCTGCAGGACCAGCCCACCCGAAACCTG
GCTGCCTTCCCAGCCTCCCATGACCCCGACCCTGCCATCCCCGCACCCACTGCCACGCCCAGTGCCCGAGGAGCTGTCATCCGCCAGAATTCAGACCCCA
CCTCTGAAGGACCTGGCCCCAGCCCGAATCCCCCAGCCTGGGTCCGCCCAGATAACGAGGCCCCACCCAAGGTGCCTCAGAGGACCTCATCTATCGCCAC
TGC
CCTTAACACCAGTGGGGCCGGAGGGTCCCGGCCAGCCCAGGCAGTCCGTGCCAGACCTCGCAGCAACTCCGCCTGGCAAATCTATCTGCAAAGGCGG
GCAGAGCGGGGCACCCCAAAGCCTCCAGGGCCCCCTGCTCAGCCCCCTGGCCCGCCCAACGCCTCTAG
TAACCCCGACCTCAGGAGGAGCGACCCTGGCT
GGGAACGCTCGGACAGCGTCCTTCCAGCCTCTCACGGGCACCTCCCCCAGGCTGGCTCACTGGAGCGGAACCGCGTGGGAGTCTCCTCCAAACCGGACAG
CTCCCCTGTGCTCTCCCCTGGGAATAAAGCCAAGCCCGACGACCACCGCTCACGGCCAGGCCGGCCCGCAGACTTTGTGTTGCTGAAAGAGCGGACTCTG
GACGAGGCCCCTCGGCCTCCCAAGAAGGCCATGGACTACTCGTCGTCCAGCGAGGAGGTGGAAAGCAGTGAGGACGACGAGGAGGAAGGCGAAGGCGGGC
CAGCAGAGGGGAGCAGAGATACCCCTGGGGGCCGCAGCGATGGGGATACAGACAGCGTCAGCACCATGGTGGTCCACGACGTCGAGGAGATCACCGGGAC
CCAGCCCCCATACGGGGGCGGCACCATGGTGGTCCAGCGCACCCCTGAAGAGGAGCGGAACCTGCTGCATGCTGACAGCAATGGGTACACAAACCTGCCT
GACGTGGTCCAGCCCAGCCACTCACCCACCGAGAACAGCAAAGGCCAAAGCCCACCCTCGAAGGATGGGAGTGGTGACTACCAGTCTCGTGGGCTGGTAA
AGGCCCCTGGCAAGAGCTCGTTCACGATGTTTGTGGATCTAGGGATCTACCAGCCTGGAGGCAGTGGGGACAGCATCCCCATCACAGCCCTAGTGGGTGG
AGAGGGCACTCGGCTCGACCAGCTGCAGTACGACGTGAGGAAGGGTTCTGTGGTCAACGTGAATCCCACCAACACCCGGGCCCACAGTGAGACCCCTGAG
ATCCGGAAGTACAAGAAGCGATTCAACTCCGAGATCCTCTGTGCAGCCCTTTGGGGGGTCAACCTGCTGGTGGGCACGGAGAACGGGCTGATGTTGCTGG
ACCGAAGTGGGCAGGGCAAGGTGTATGGACTCATTGGGCGGCGACGCTTCCAGCAGATGGATGTGCTGGAGGGGCTCAACCTGCTCATCACCATCTCAGG
GAAAAGGAACAAACTGCGGGTGTATTACCTGTCCTGGCTCCGGAACAAGATTCTGCACAATGACCCAGAAGTGGAGAAGAAGCAGGGCTGGACCACCGTG
GGGGACATGGAGGGCTGCGGGCACTACCGTGTTGTGAAATACGAGCGGATTAAGTTCCTGGTCATCGCCCTCAAGAGCTCCGTGGAGGTGTATGCCTGGG
CCCCCAAACCCTACCACAAATTCATGGCCTTCAAGTCCTTTGCCGACCTCCCCCACCGCCCTCTGCTGGTCGACCTGACAGTAGAGGAGGGGCAGCGGCT
CAAGGTCATCTATGGCTCCAGTGCTGGCTTCCATGCTGTGGATGTCGACTCGGGGAACAGCTATGACATCTACATCCCTGTGCACATCCAGAGCCAGATC
ACGCCCCATGCCATCATCTTCCTCCCCAACACCGACGGCATGGAGATGCTGCTGTGCTACGAGGACGAGGGTGTCTACGTCAACACGTACGGGCGCATCA
TTAAGGATGTGGTGCTGCAGTGGGGGGAGATGCCTACTTCTGTGGCCTACATCTGCTCCAACCAGATAATGGGCTGGGGTGAGAAAGCCATTGAGATCCG
CTCTGTGGAGACGGGCCACCTCGACGGGGTCTTCATGCACAAACGAGCTCAGAGGCTCAAGTTCCTGTGTGAGCGGAATGACAAGGTGTTTTTTGCCTCA
GTCCGCTCTGGGGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTG
GACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGG
AACGTGACCTCTGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCTTCCCAAAACTGTGCCTGTCCCCAGCTTCTGGGGA
GGGACACAGCTTCCCCTTCCCAGGAATTGAGTGGGCCTAGCCCCTCCCCCCTTTTCTCCATTTGAGAGGAGAGTGCTTGGGGCTTGAACCCCTTACCCCA
CTGCTGCTGACTGGGCAGGGCCCTGGACCCCTTTATTTGCACGTCAGGGGAGCCGGCTCCCCCCTTGAATGTACCAGACCCTGGGGGGGGTCACTGGGCC
CTAGATTTTTGGGGGGTCACCAGCCACTCCAGGGGCAGGGACCATTTCTTCATTTTCTGAAAGCACTTTAATGATTCCCCTTCCCCCAAACTCCAGGGAA
TGGAGGGGGGACCCCGCCAGCCAAAACATTCCCCCCATTCCCGACCCCCCTCTCCTCTTCTAGCCCATGCCCTTCCCCGGTGGAGGGAGGGAGCAGGGAG
CCCTCACTCTCCACGCCCCTTGCTTGCATCTGTATATAGTGTGAGCAGCAAGTAACCCTTCTCCTCCCTCCCCCCTCCCCCCTCCTCAATGTAGTGGCCT
TGGATATCCTGTTTGTTAATAAAGACAATTCAACCAGCTCCCACCA
  • refseq_MINK1.F3 (forward primer)
  • refseq_MINK1.R3 (reverse primer)
  • Single exon skipping

Frame 0

GWLRGDSACQSVGRSSRRPSPSPVSGGGAVESA
PGVLRWGRSGDGGSGVTEPERERPRCPVPHGGHG
RPSPRPQPGRHRPVRPADRGQGAETLVMEFCGA
GSVTDLVKNTKGNALKEDCIAYICREILRGLAH
LHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQ
LDRTVGRRNTFIGTPYWMAPEVIACDENPDATY
DYRSDIWSLGITAIEMAEGAPPLCDMHPMRALF
LIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSR
PPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSR
KKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIM
NVPGESTLRREFLRLQQENKSNSEALKQQQQLQQ
QQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEE
QQRREREQRKLQEKEQQRRLEDMQALRREEERR
QAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLK
SLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRG
MNPADKPAWAREVEERTRMNKQQNSPLAKSKPG
STGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEG
PHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNL
AAFPASHDPDPAIPAPTATPSARGAVIRQNSDP
TSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIAT
A
LNTSGAGGSRPAQAVRARPRSNSAWQIYLQRR
AERGTPKPPGPPAQPPGPPNASS
NPDLRRSDPG
WERSDSVLPASHGHLPQAGSLERNRVGVSSKPDS
SPVLSPGNKAKPDDHRSRPGRPADFVLLKERTL
DEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGG
PAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGT
QPPYGGGTMVVQRTPEEERNLLHADSNGYTNLP
DVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLV
KAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGG
EGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPE
IRKYKKRFNSEILCAALWGVNLLVGTENGLMLL
DRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISG
KRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTV
GDMEGCGHYRVVKYERIKFLVIALKSSVEVYAW
APKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRL
KVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQI
TPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRI
IKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIR
SVETGHLDGVFMHKRAQRLKFLCERNDKVFFAS
VRSGGSSQVYFMTLNRNCIMNW*RGPGLGLSHT
GPSSPPAARLPGPPLFPLPGLLLLLV*FHWSLLG
T*PLTPDAFVIT*PSSSPTCPLPKTVPVPSFWG
GTQLPLPRN*VGLAPPPFSPFERRVLGA*TPYP
TAADWAGPWTPLFARQGSRLPP*MYQTLGGVTGP
*IFGGSPATPGAGTISSFSESTLMIPLPPNSRE
WRGDPASQNIPPIPDPPLLF*PMPFPGGGREQG
ALTLHAPCLHLYIV*AASNPSPPSPLPPPQCSGL
GYPVC**RQFNQLPP

Frame 1

AGSGEIAPVSRWVGPRAGPPPPRSPGEARWSPP
PGFSDGGEAATAAVE*PSRSVSGPGAPFPTEAM
GDPAPARSLDDIDLSALRTEDKEQRPW*WSSVVL
VQ*LTW*RTQKAMP*RRTVSPISAGRSSGVWPI
SMPTR*SIETSRGRMCC*QRMLRSS*WILG*VL
SWTAPWADGTLSLGLPTGWLQRSSPVMRTLMPPM
ITGVIFGL*ESQPSRWQREPPLCVTCTPCEPSS
SFLGTLRPGSSPRSGLRSSLTSLTHVSSRLT*A
AHPRSSY*SFPSSGTSPRSGRSASSLRTTLTDPG
RSGVRKRRQNMSTAAARRKMTAMERKESQAPS*
TCLESRLYAGSFSGSSRKIRATQRL*NSSSSCS
SSSSETPRHTSNTCCTSGSGA*RSRRRSGAAWRS
NSGGSGSSGSCRRRSSSGGWRTCRLCGGRRSGG
RRSASRNTSGSSWRSSGSQNVSRGSCSRSMPTS
SPCSSSNSSSSFRNSSSSSSCLGTGSPCTIMVGA
*IPLTNQPGPER*KREQG*TSSRTLPWPRASQA
ARGLSPPSPRPPQGPQDPFPRLLLCRGRWSPRR
DRTRAWWHTGSH*SHMQHLYPDPSPCRTSPPETW
LPSQPPMTPTLPSPHPLPRPVPEELSSARIQTP
PLKDLAPARIPQPGSAQITRPHPRCLRGPHLSP
L
PLTPVGPEGPGQPRQSVPDLAATPPGKSICKGG
QSGAPQSLQGPLLSPLARPTPL
VTPTSGGATLA
GNARTASFQPLTGTSPRLAHWSGTAWESPPNRT
APLCSPLGIKPSPTTTAHGQAGPQTLCC*KSGLW
TRPLGLPRRPWTTRRPARRWKAVRTTRRKAKAG
QQRGAEIPLGAAAMGIQTASAPWWSTTSRRSPG
PSPHTGAAPWWSSAPLKRSGTCCMLTAMGTQTCL
TWSSPATHPPRTAKAKAHPRRMGVVTTSLVGW*
RPLARARSRCLWI*GSTSLEAVGTASPSQP*WV
ERALGSTSCSTT*GRVLWST*IPPTPGPTVRPLR
SGSTRSDSTPRSSVQPFGGSTCWWARRTG*CCW
TEVGRARCMDSLGGDASSRWMCWRGSTCSSPSQ
GKGTNCGCITCPGSGTRFCTMTQKWRRSRAGPPW
GTWRAAGTTVL*NTSGLSSWSSPSRAPWRCMPG
PPNPTTNSWPSSPLPTSPTALCWST*Q*RRGSG
SRSSMAPVLASMLWMSTRGTAMTSTSLCTSRARS
RPMPSSSSPTPTAWRCCCATRTRVSTSTRTGAS
LRMWCCSGGRCLLLWPTSAPTR*WAGVRKPLRS
ALWRRATSTGSSCTNELRGSSSCVSGMTRCFLPQ
SALGAAAKFTS*L*TVTAS*TGDGALGWGCPTL
DPALPLQPGFPGRPSFPSLGFCFYWFDFTGACW
ERDL*PLMLS*SRDHPLPQHVLFPKLCLSPASGE
GHSFPFPGIEWA*PLPPFLHLRGECLGLEPLTP
LLLTGQGPGPLYLHVRGAGSPLECTRPWGGSLG
PRFLGGHQPLQGQGPFLHFLKAL**FPFPQTPGN
GGGTPPAKTFPPFPTPLSSSSPCPSPVEGGSRE
PSLSTPLACICI*CEQQVTLLLPPPSPLLNVVA
LDILFVNKDNSTSSH

Frame 2

LAPGR*RLSVGGSVLAPALPLPGLRGRRGGVRP
RGSPMGEKRRRRQWSNRAGA*AAPVPRSPRRPW
ATQPPPAAWTTSTCPPCGQRTRSRDPGDGVLWC
WFSD*PGKEHKRQCPEGGLYRLYLQGDPQGSGPS
PCPQGDPSRHQGAECAADREC*GQASGFWGECS
AGPHRGQTEHFHWDSLLDGSRGHRL**EP*CHL
*LQE*YLVSRNHSHRDGRGSPPSV*HAPHASPLP
HSSEPSAQAQVQEVV*EVH*LH*HMSHQDLPEP
PTHGAATEVSLHPGPAHGAAGPHPA*GPH*PIP
EEAG*ERGDRI*VQRQRGGR*QPWRGRRAKLHHE
RAWRVDSTPGVSPAPAGK*EQLRGFKTAAAAAA
AAAARPRGTHQTPAAPAAAAHRGAEGGAAPRGG
ATAAGAGAAEAAGEGAAAAAGGHAGSAAGGGAAA
GGARAGIQAEAAGGAAAVRTSPEAAAAGACLPQ
VPAAAATAAAASETAAAAAPAWGQEAPVPLWSG
HESR*QTSLGPRGRRENKDEQAAELSLGQEQARQ
HGA*APHPPGLPRAPRTPFPDSSYAEAGGAPGG
TAQEPGGTPGPTEAICSTCTPIPVPAGPAHPKP
GCLPSLP*PRPCHPRTHCHAQCPRSCHPPEFRPH
L*RTWPQPESPSLGPPR*RGPTQGASEDLIYRH
C
P*HQWGRRVPASPGSPCQTSQQLRLANLSAKA
GRAGHPKASRAPCSAPWPAQRL*
*PRPQEERPWL
GTLGQRPSSLSRAPPPGWLTGAEPRGSLLQTGQ
LPCALPWE*SQARRPPLTARPARRLCVAERADS
GRGPSASQEGHGLLVVQRGGGKQ*GRRGGRRRRA
SRGEQRYPWGPQRWGYRQRQHHGGPRRRGDHRD
PAPIRGRHHGGPAHP*RGAEPAAC*QQWVHKPA
*RGPAQPLTHREQQRPKPTLEGWEW*LPVSWAGK
GPWQELVHDVCGSRDLPAWRQWGQHPHHSPSGW
RGHSARPAAVRREEGFCGQRESHQHPGPQ*DP*
DPEVQEAIQLRDPLCSPLGGQPAGGHGERADVAG
PKWAGQGVWTHWAATLPADGCAGGAQPAHHHLR
EKEQTAGVLPVLAPEQDSAQ*PRSGEEAGLDHR
GGHGGLRALPCCEIRAD*VPGHRPQELRGGVCLG
PQTLPQIHGLQVLCRPPPPPSAGRPDSRGGAAA
QGHLWLQCWLPCCGCRLGEQL*HLHPCAHPEPD
HAPCHHLPPQHRRHGDAAVLRGRGCLRQHVRAHH
*GCGAAVGGDAYFCGLHLLQPDNGLG*ESH*DP
LCGDGPPRRGLHAQTSSEAQVPV*AE*QGVFCL
SPLWGQQPSLLHDSEP*LHHELVTGPWAGAVPHW
TQLSPCSQASRAAPLSPPWAFAFTGLISLEPAG
NVTSDP*CFRDHVTILFPNMSSSQNCACPQLLG
RDTASPSQELSGPSPSPLFSI*EESAWGLNPLPH
CC*LGRALDPFICTSGEPAPPLNVPDPGGGHWA
LDFWGVTSHSRGRDHFFIF*KHFNDSPSPKLQG
MEGGPRQPKHSPHSRPPSPLLAHALPRWREGAGS
PHSPRPLLASVYSVSSK*PFSSLPPPPSSM*WP
WISCLLIKTIQPAPT

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