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Sequences

Sequence NM_203318

TCCATCCCTGACCGGGCCGAGGCTGCTGGATGCCGCGTCTCCGCTTCTGCTGCCTGCCGGGCGGGCTCCGGTGGCCGCAGCAAAGTGGGGCACCAAGGCC CTGTGCTAAGCACTCATAATCCTCTGGGGGTGCTACCCCTACAAACAGCACCCCCACCATGTTTAACCTAATGAAGAAAGACAAGGACAAAGATGGCGGG CGGAAGGAGAAGAAGGAGAAAAAGGAGAAAAAGGAGCGGATGTCAGCGGCAGAGCTTCGGAGCCTGGAGGAGATGAGCCTGCGACGTGGCTTCTTCAACC TGAACCGCTCCTCCAAGCGTGAATCCAAGACGCGCCTGGAAATCTCCAACCCCATCCCCATCAAGGTGGCCAGCGGCTCTGACCTGCACCTGACTGACAT TGACTCCGATAGTAACCGGGGCAGCGTCATCCTGGACTCGGGCCACCTAAGTACAGCCAGCTCCAGCGATGACCTCAAGGGTGAGGAGGGTAGCTTCCGT GGCTCGGTGCTGCAGCGGGCAGCCAAGTTCGGCTCACTGGCCAAGCAGAACTCACAGATGATTGTCAAGCGCTTTTCCTTCTCCCAGCGTAGCCGGGATG AGAGCGCCTCAGAAACCTCGACGCCCTCAGAGCACTCTGCCGCCCCCTCGCCACAGGTGGAGGTGAGGACTCTAGAGGGACAGCTGGTGCAGCATCCTGG CCCAGGCATCCCTCGACCAGGGCACCGATCCCGAGCCCCTGAGCTAGTGACTAAAAAGTTCCCAGTCGACCTGCGCCTGCCCCCCGTGGTGCCCCTGCCC CCACCTACCCTCCGGGAGCTGGAGCTGCAACGACGGCCCACTGGAGACTTTGGCTTCTCCCTGCGGCGCACAACCATGCTGGATCGGGGCCCCGAGGGCC AGGCCTGTCGGCGTGTGGTCCACTTTGCTGAGCCTGGTGCAGGCACCAAGGACCTGGCCCTGGGGCTGGTGCCAGGAGATCGACTGGTGGAGATTAATGG GCACAATGTGGAGAGCAAGTCCAGGGATGAGATTGTGGAGATGATCCGGCAGTCAGGGGACAGCGTGCGGCTCAAGGTGCAGCCCATTCCAGAGCTCAGC GAGCTCAGCAGGAGCTGGCTGCGGAGCGGCGAGGGACCTCGCAGGGAGCCATCCGATGCGAAAACAGAAGAACAGATTGCAGCAGAAGAGGCCTGGAATG AGACGGAGAAGGTGTGGCTGGTCCATAGGGACGGCTTCTCACTGGCCAGTCAACTCAAATCTGAGGAGCTCAACTTGCCTGAGGGGAAGGTGCGTGTGAA GCTGGACCACGATGGGGCCATCCTGGATGTGGATGAGGATGACGTTGAGAAGGCTAATGCTCCCTCCTGCGACCGTCTGGAGGATCTGGCCTCACTGGTG TACCTCAATGAGTCCAGCGTCCTGCACACCTTGCGCCAGCGCTATGGCGCTAGCCTGCTGCACACGTATGCTGGCCCCAGCCTGCTGGTTCTTGGCCCCC GTGGGGCCCCTGCTGTGTACTCTGAGAAGGTGATGCACATGTTCAAGGGTTGTCGGCGGGAGGACATGGCACCCCACATCTATGCAGTGGCCCAGACCGC ATACAGGGCGATGCTGATGAGCCGTCAGGATCAGTCAATCATCCTCCTGGGCAGTAGTGGCAGTGGCAAGACCACCAGCTGCCAGCATCTGGTGCAGTAC CTGGCCACCATCGCGGGCATCAGCGGGAACAAGGTGTTTTCTGTGGAGAAGTGGCAGGCTCTGTACACCCTCCTGGAAGCCTTTGGGAACAGCCCCACCA TCATTAATGGCAATGCCACCCGCTTCTCCCAGATCCTCTCCCTGGACTTTGACCAAGCTGGCCAGGTGGCCTCAGCCTCCATTCAGACAATGCTTCTGGA GAAGCTGCGTGTGGCTCGGCGCCCAGCCAGTGAAGCCACATTCAACGTCTTCTACTACCTGCTGGCCTGTGGGGATGGCACCCTCAGGACAGAGCTCCAC CTCAACCACTTGGCAGAGAACAATGTGTTTGGGATTGTGCCACTGGCCAAGCCTGAGGAAAAGCAGAAGGCAGCTCAGCAGTTTAGTAAGCTGCAGGCGG CCATGAAGGTGCTGGGCATCTCCCCCGATGAACAGAAGGCCTGCTGGTTCATTCTGGCTGCCATCTACCACCTGGGGGCTGCGGGAGCCACCAAAGAAGC TGCTGAAGCTGGGCGCAAGCAGTTTGCCCGCCATGAGTGGGCCCAGAAGGCTGCGTACCTACTGGGCTGCAGCCTGGAGGAGCTGTCCTCAGCCATCTTC AAGCACCAGCACAAGGGTGGCACCCTGCAGCGCTCCACCTCCTTCCGCCAGGGCCCCGAGGAGAGTGGCCTGGGAGATGGGACAGGCCCGAAACTGAGTG CACTGGAGTGCCTTGAGGGCATGGCGGCCGGCCTCTACAGCGAGCTCTTCACCCTTCTCGTCTCCCTGGTGAATAGGGCTCTCAAGTCCAGCCAGCACTC ACTCTGCTCCATGATGATTGTCGACACCCCGGGCTTCCAGAACCCTGAGCAGGGTGGGTCAGCCCGCGGAGCCTCCTTTGAGGAGCTGTGCCACAACTAC ACCCAAGACCGGCTGCAGAGGCTCTTCCACGAGCGCACCTTCGTGCAGGAGTTGGAAAGATACAAGGAGGAGAACATCGAGCTGGCGTTTGACGACTTGG AACCCCCGACGGATGACTCTGTGGCTGCTGTGGACCAGGCCTCCCATCAGTCCCTGGTCCGCTCGCTGGCCCGCACAGACGAGGCGAGGGGCCTGCTCTG GCTATTGGAAGAGGAGGCTCTGGTGCCAGGGGCCAGTGAGGACACCCTCCTGGAGCGCCTTTTCTCCTATTATGGCCCCCAGGAAGGTGACAAAAAAGGC CAAAGCCCCCTTCTGCACAGCAGCAAACCACACCACTTTCTCCTGGGCCACAGCCATGGCACCAACTGGGTAGAGTACAATGTGACTGGCTGGCTGAACT ACACCAAGCAGAACCCAGCCACCCAGAATGCCCCCCGGCTCCTGCAGGACTCCCAGAAAAAAATCATCAGCAACCTGTTTCTGGGCCGCGCAGGCAGTGC CACGGTGCTCTCTGGCTCCATCGCGGGCCTGGAGGGCGGCTCGCAGCTGGCACTGCGCCGGGCCACCAGCATGCGGAAAACCTTTACCACAGGCATGGCG GCTGTCAAAAAGAAGTCACTGTGCATCCAGATGAAGCTACAGGTGGACGCCCTCATCGACACCATCAAGAAGTCAAAGCTGCATTTTGTGCACTGCTTCC TGCCTGTAGCTGAGGGCTGGGCTGGGGAGCCCCGTTCCGCCTCCTCCCGCCGAGTCAGCAGCAGCAGTGAGCTGGACCTGCCCTCGGGAGACCACTGCGA GGCTGGGCTCCTGCAGCTCGACGTGCCCCTGCTCCGCACCCAGCTCCGCGGCTCCCGCCTGCTCGATGCCATGCGCATGTACCGCCAAGGTTACCCTGAC CACATGGTGTTTTCCGAGTTCCGCCGCCGCTTTGATGTCCTGGCCCCGCACCTGACCAAGAAACACGGGCGTAACTACATCGTGGTGGATGAAAGGCGGG CAGTGGAGGAGCTGCTGGAGTGCTTGGATCTGGAGAAGAGCAGCTGCTGCATGGGCCTGAGCCGGGTGTTCTTCCGGGCGGGCACCTTGGCACGGCTGGA GGAGCAGCGGGATGAACAAACCAGCAGGAACCTAACCCTGTTCCAAGCAGCCTGCAGGGGCTACCTGGCCCGCCAGCACTTCAAGAAGAGAAAGATCCAG GACCTGGCCATTCGCTGTGTACAGAAGAACATCAAGAAGAACAAAGGGGTGAAGGACTGGCCCTGGTGGAAGCTTTTTACCACAGTGAGGCCCCTCATCG AAGTACAGCTGTCAGAGGAGCAGATCCGGAACAAAGACGAGGAGATCCAGCAGCTGCGGAGCAAGCTCGAGAAGGCGGAGAAGGAGAGGAACGAGCTGCG GCTCAACAGTGACCGGCTGGAGAGCCGGATCTCAGAGCTGACATCGGAGCTGACAGATGAGCGTAACACAGGAGAGTCCGCCTCCCAGCTGCTGGACGCG GAGACAGCAGAGAGGCTCCGGGCTGAGAAGGAGATGAAGGAACTGCAGACCCAGTACGATGCACTGAAGAAGCAGATGGAGGTTATGGAAATGGAGGTGA TGGAGGCCCGTCTCATCCGGGCAGCGGAGATCAACGGGGAAGTGGATGATGATGATGCAGGTGGCGAGTGGCGGCTGAAGTATGAGCGGGCTGTGCGGGA GGTGGACTTCACCAAGAAACGGCTCCAGCAGGAGTTTGAGGACAAGCTGGAGGTGGAGCAGCAGAACAAGAGGCAGCTGGAACGGCGGCTCGGGGACCTG CAGGCAGATAGTGAGGAGAGTCAGCGGGCTCTGCAGCAGCTCAAGAAGAAGTGCCAGCGACTGACGGCTGAGCTGCAAGACACCAAGCTGCACCTGGAGG GCCAGCAGGTCCGCAACCACGAACTGGAGAAGAAGCAGAGGAGGTTTGACAGTGAGCTCTCGCAGGCGCATGAGGAGGCCCAGCGGGAGAAGCTGCAGCG GGAGAAGCTGCAGCGGGAGAAGGACATGCTCCTCGCTGAGGCTTTCAGCCTGAAGCAGCAACTAGAGGAAAAAGACATGGACATTGCAGGGTTCACCCAG AAGGTTGTGTCTCTAGAGGCAGAGCTCCAGGACATTTCTTCCCAAGAGTCCAAGGATGAGGCTTCTCTGGCCAAGGTCAAGAAACAGCTCCGGGACCTGG AGGCCAAAGTCAAGGATCAGGAAGAAGAGCTGGATGAGCAGGCAGGGACCATCCAGATGCTGGAACAGGCCAAGCTGCGTCTGGAGATGGAGATGGAGCG GATGAGACAGACCCATTCTAAGGAGATGGAGAGTCGGGATGAGGAGGTGGAGGAGGCCCGGCAGTCGTGTCAGAAGAAGTTAAAACAGATGGAGGTGCAG CTAGAGGAAGAGTATGAGGACAAGCAGAAGGTTCTGCGAGAGAAGCGGGAGCTGGAGGGCAAGCTCGCCACCCTCAGCGACCAGGTGAACCGGCGGGACT TTGAGTCAGAGAAGCGGCTGCGGAAGGACCTGAAGCGCACCAAGGCCCTGCTGGCAGATGCCCAGCTCATGCTGGACCACCTGAAGAACAGTGCTCCCAG CAAGCGAGAGATTGCCCAGCTCAAGAACCAGCTGGAGGAGTCAGAGTTCACCTGTGCGGCAGCCGTGAAAGCACGGAAAGCAATGGAGGTGGAGATCGAA GACCTGCACCTGCAGATTGATGACATCGCCAAAGCCAAGACAGCGCTGGAGGAGCAGCTGAGCCGCCTTCAGCGTGAGAAGAATGAGATCCAGAACCGGC TGGAGGAAGATCAGGAAGACATGAACGAATTGATGAAGAAGCACAAGGCTGCCGTGGCTCAGGCTTCCCGGGACCTGGCTCAGATAAATGATCTCCAAGC TCAGCTAGAAGAAGCCAACAAAGAGAAGCAGGAGCTGCAGGAGAAGCTACAAGCCCTCCAGAGCCAGGTGGAGTTCCTGGAGCAGTCCATGGTGGACAAG TCCCTGGTGAGCAGGCAGGAAGCTAAGATACGGGAGCTGGAGACACGCCTGGAGTTTGAAAGGACGCAAGTGAAACGGCTGGAGAGCCTGGCTAGCCGTC TCAAGGAAAACATGGAGAAGCTGACTGAGGAGCGGGATCAGCGCATTGCAGCCGAGAACCGGGAGAAGGAACAGAACAAGCGGCTACAGAGGCAGCTCCG GGACACCAAGGAGGAGATGGGCGAGCTTGCCAGGAAGGAGGCCGAGGCGAGCCGCAAGAAGCACGAACTGGAGATGGATCTAGAAAGCCTGGAGGCTGCT AACCAGAGCCTGCAGGCTGACCTAAAGTTGGCATTCAAGCGCATCGGGGACCTGCAGGCTGCCATTGAGGATGAGATGGAGAGTGATGAGAATGAGGACC TCATCAACAGTGAGGGAGACTCTGATGTGGACTCGGAGCTGGAGGACCGTGTTGACGGGGTCAAGTCCTGGTTGTCAAAAAACAAGGGACCTTCCAAGGC AGCTTCTGATGATGGCAGCTTAAAGAGTTCCAGCCCCACCAGCTACTGGAAGTCCCTTGCCCCTGATCGGTCAGATGATGAGCACGACCCTCTCGACAAC ACCTCCAGACCGCGATACTCCCACAGTTATCTGAGTGACAGCGACACAGAGGCCAAGCTGACGGAGACTAACGCATAGCCCAGGGGAGTGGTTGGCAGCC CTCTCACCCCAGGGCCTGTGGCTGCCTGGGCACCTCTCCCAGGAAGTGGTGGGGCACCGGTCTCCCCCACCCGACTGCTGATCTGCATGGGAAACACCCT GACCTTCTTCTGTCAGGGGCACTTTCCAGGCTATGGGTGTCTGATGTCTCCACGTGGAAGAGGTGGGGGAAAGAGGAGTTTCTGAAGAGAACTTTTTGCT CCTCTGTCTCAAAATGCCAGACTCTTGGCTTCTACCCTGTGTCACCGTGGGCAGTGGCAGGTGGCCTGGCACTGCATGGAGCCAGCACGTTGACCTCCCT CTCAGCTCCCTGCTCAGGGACGGTGGACAGGTTGCCTACTGGGACACTCTAGGTTGCTGGGTCCATGGGGAGGATTGGGGGAGGAGAAGCAGTGCCTTCC CTCTCGTGTGGGGTGGGGGCTCTCTCTTCTTGGTGCCTGCTGTCTTTCTACTTTTTAATTTAAATACCCAACCTCTCCATCACAGCTGCATCCCTGAGAG TGGGAGGGGGCTGTAGTGGTAGCTGGGGCTCCCAAGAACGACTCGGGAATGTCATCTCCATCTTCACCCTTCAGAGAGCAGTCCTTTCTCTGTGCAGCTG GAGACGCTGGTGAGGAGAGCCGGGTCCAGGTTCTTAAGAATGAGGTGCGGAGGGGCTCTCCGGTGCTGCTGGGCTGGGTTGAGCAAGCCTACGCAGACAA GTGTGTGTGTGGACCATCCGCACCTCCAGCCCCCACCCCACCCTCTTTGTCTCAGCGTGTTATGTGCAATGACCTATTTAAGGTAAACCCATTCCAACTA CAGCAGTTCAGGGCTGATCCAAGCACTGCCTCCCTCCTGCTCTGTCCAGGTGGTCTGGACCATAAACTCAACTTGAGAGGGAAGGCTTGGGGTTGAGGAC TTGTGATCAGAAAAACTGAAGATGGAAGTTTTGGCCGGTGCTCATTAGACATGAGTCCTCACTCTGTGTCCTGAGCCCGTGTCATTCTTCCAACCTCCCT GCCCCCACACACTTATCCCAGACACAACACCATGTGGTCTGGAGGTCCCAGCCCCCACCCTAAAAAGGTTATCCCTGAGAACTCCACCAGACTTGGGAGC CCAAGTGCAGTGCCTGGTGCTGCTCCCATCTGCCGCCCCCCTTCTCTCCTGCAATTGGTTTGTACTCACTGGGCTGTGCTCTCCCCTGTTTACCCGATGT ATGGAAATAAAGGCCCTTTTCCTCCTGGCTGCGCCAGT

refseq_MYO18A.F2 (forward primer)
refseq_MYO18A.R2 (reverse primer)
Single exon skipping

Frame 0

SIPDRAEAAGCRVSASAACRAGSGGRSKVGHQG PVLSTHNPLGVLPLQTAPPPCLT**RKTRTKMAG GRRRRRKRRKRSGCQRQSFGAWRR*ACDVASST *TAPPSVNPRRAWKSPTPSPSRWPAALTCT*LT LTPIVTGAASSWTRAT*VQPAPAMTSRVRRVASV ARCCSGQPSSAHWPSRTHR*LSSAFPSPSVAGM RAPQKPRRPQSTLPPPRHRWR*GL*RDSWCSIL AQASLDQGTDPEPLS**LKSSQSTCACPPWCPCP HLPSGSWSCNDGPLETLASPCGAQPCWIGAPRA RPVGVWSTLLSLVQAPRTWPWGWCQEIDWWRLM GTMWRASPGMRLWR*SGSQGTACGSRCSPFQSSA SSAGAGCGAARDLAGSHPMRKQKNRLQQKRPGM RRRRCGWSIGTASHWPVNSNLRSSTCLRGRCV* SWTTMGPSWMWMRMTLRRLMLPPATVWRIWPHWC TSMSPASCTPCASAMALACCTRMLAPACWFLAP VGPLLCTLRR*CTCSRVVGGRTWHPTSMQWPRP HTGRC**AVRISQSSSWAVVAVARPPAASIWCST WPPSRASAGTRCFLWRSGRLCTPSWKPLGTAPP SLMAMPPASPRSSPWTLTKLARWPQPPFRQCFW RSCVWLGAQPVKPHSTSSTTCWPVGMAPSGQSST STTWQRTMCLGLCHWPSLRKSRRQLSSLVSCRR P*RCWASPPMNRRPAGSFWLPSTTWGLREPPKK LLKLGASSLPAMSGPRRLRTYWAAAWRSCPQPSS STSTRVAPCSAPPPSARAPRRVAWEMGQARN*V HWSALRAWRPASTASSSPFSSPW*IGLSSPAST HSAP**LSTPRASRTLSRVGQPAEPPLRSCATTT PKTGCRGSSTSAPSCRSWKDTRRRTSSWRLTTW NPRRMTLWLLWTRPPISPWSARWPAQTRRGACS GYWKRRLWCQGPVRTPSWSAFSPIMAPRKVTKKA KAPFCTAANHTTFSWATAMAPTG*STM*LAG*T TPSRTQPPRMPPGSCRTPRKKSSATCFWAAQAV PRCSLAPSRAWRAARSWHCAGPPACGKPLPQAWR LSKRSHCASR*SYRWTPSSTPSRSQSCILCTAS CL*LRAGLGSPVPPPPAESAAAVSWTCPRETTA RLGSCSSTCPCSAPSSAAPACSMPCACTAKVTLT TWCFPSSAAALMSWPRT*PRNTGVTTSWWMKGG QWRSCWSAWIWRRAAAAWA*AGCSSGRAPWHGW RSSGMNKPAGT*PCSKQPAGATWPASTSRRERSR TWPFAVYRRTSRRTKG*RTGPGGSFLPQ*GPSS KYSCQRSRSGTKTRRSSSCGASSRRRRRRGTSC GSTVTGWRAGSQS*HRS*QMSVTQESPPPSCWTR RQQRGSGLRRR*RNCRPSTMH*RSRWRLWKWR* WRPVSSGQRRSTGKWMMMMQVASGG*SMSGLCG RWTSPRNGSSRSLRTSWRWSSRTRGSWNGGSGTC RQIVRRVSGLCSSSRRSASD*RLSCKTPSCTWR ASRSATTNWRRSRGGLTVSSRRRMRRPSGRSCS GRSCSGRRTCSSLRLSA*SSN*RKKTWTLQGSPR RLCL*RQSSRTFLPKSPRMRLLWPRSRNSSGTW RPKSRIRKKSWMSRQGPSRCWNRPSCVWRWRWS G*DRPILRRWRVGMRRWRRPGSRVRRS*NRWRCS *RKSMRTSRRFCERSGSWRASSPPSATR*TGGT LSQRSGCGRT*SAPRPCWQMPSSCWTT*RTVLP ASERLPSSRTSWRSQSSPVRQP*KHGKQWRWRSK TCTCRLMTSPKPRQRWRSS*AAFSVRRMRSRTG WRKIRKT*TN**RSTRLPWLRLPGTWLR*MISK LS*KKPTKRSRSCRRSYKPSRARWSSWSSPWWTS PW*AGRKLRYGSWRHAWSLKGRK*NGWRAWLAV SRKTWRS*LRSGISALQPRTGRRNRTSGYRGSS GTPRRRWASLPGRRPRRAARSTNWRWI*KAWRLL TRACRLT*SWHSSASGTCRLPLRMRWRVMRMRT SSTVRETLMWTRSWRTVLTGSSPGCQKTRDLPR QLLMMAA*RVPAPPATGSPLPLIGQMMSTTLSTT PPDRDTPTVI*VTATQRPS*RRLTHSPGEWLAA LSPQGLWLPGHLSQEVVGHRSPPPDC*SAWETP *PSSVRGTFQAMGV*CLHVEEVGERGVSEENFLL LCLKMPDSWLLPCVTVGSGRWPGTAWSQHVDLP LSSLLRDGGQVAYWDTLGCWVHGEDWGRRSSAF PLVWGGGSLFLVPAVFLLFNLNTQPLHHSCIPES GRGL*W*LGLPRTTRECHLHLHPSESSPFSVQL ETLVRRAGSRFLRMRCGGALRCCWAGLSKPTQT SVCVDHPHLQPPPHPLCLSVLCAMTYLR*THSNY SSSGLIQALPPSCSVQVVWTINST*EGRLGVED L*SEKLKMEVLAGAH*T*VLTLCPEPVSFFQPP CPHTLIPDTTPCGLEVPAPTLKRLSLRTPPDLGA QVQCLVLLPSAAPLLSCNWFVLTGLCSPLFTRC MEIKALFLLAAP

Frame 1

PSLTGPRLLDAASPLLLPAGRAPVAAAKWGTKA LC*ALIILWGCYPYKQHPHHV*PNEERQGQRWR AEGEEGEKGEKGADVSGRASEPGGDEPATWLLQP EPLLQA*IQDAPGNLQPHPHQGGQRL*PAPD*H *LR**PGQRHPGLGPPKYSQLQR*PQG*GG*LP WLGAAAGSQVRLTGQAELTDDCQALFLLPA*PG* ERLRNLDALRALCRPLATGGGEDSRGTAGAASW PRHPSTRAPIPSP*ASD*KVPSRPAPAPRGAPA PTYPPGAGAATTAHWRLWLLPAAHNHAGSGPRGP GLSACGPLC*AWCRHQGPGPGAGARRSTGGD*W AQCGEQVQG*DCGDDPAVRGQRAAQGAAHSRAQ RAQQELAAERRGTSQGAIRCENRRTDCSRRGLE* DGEGVAGP*GRLLTGQSTQI*GAQLA*GEGACE AGPRWGHPGCG*G*R*EG*CSLLRPSGGSGLTG VPQ*VQRPAHLAPALWR*PAAHVCWPQPAGSWPP WGPCCVL*EGDAHVQGLSAGGHGTPHLCSGPDR IQGDADEPSGSVNHPPGQ*WQWQDHQLPASGAV PGHHRGHQREQGVFCGEVAGSVHPPGSLWEQPHH H*WQCHPLLPDPLPGL*PSWPGGLSLHSDNASG EAACGSAPSQ*SHIQRLLLPAGLWGWHPQDRAP PQPLGREQCVWDCATGQA*GKAEGSSAV**AAGG HEGAGHLPR*TEGLLVHSGCHLPPGGCGSHQRS C*SWAQAVCPP*VGPEGCVPTGLQPGGAVLSHL QAPAQGWHPAALHLLPPGPRGEWPGRWDRPETEC TGVP*GHGGRPLQRALHPSRLPGE*GSQVQPAL TLLHDDCRHPGLPEP*AGWVSPRSLL*GAVPQL HPRPAAEALPRAHLRAGVGKIQGGEHRAGV*RLG TPDG*LCGCCGPGLPSVPGPLAGPHRRGEGPAL AIGRGGSGARGQ*GHPPGAPFLLLWPPGR*QKR PKPPSAQQQTTPLSPGPQPWHQLGRVQCDWLAEL HQAEPSHPECPPAPAGLPEKNHQQPVSGPRRQC HGALWLHRGPGGRLAAGTAPGHQHAENLYHRHG GCQKEVTVHPDEATGGRPHRHHQEVKAAFCALLP ACS*GLGWGAPFRLLPPSQQQQ*AGPALGRPLR GWAPAARRAPAPHPAPRLPPARCHAHVPPRLP* PHGVFRVPPPL*CPGPAPDQETRA*LHRGG*KAG SGGAAGVLGSGEEQLLHGPEPGVLPGGHLGTAG GAAG*TNQQEPNPVPSSLQGLPGPPALQEEKDP GPGHSLCTEEHQEEQRGEGLALVEAFYHSEAPHR STAVRGADPEQRRGDPAAAEQAREGGEGEERAA AQQ*PAGEPDLRADIGADR*A*HRRVRLPAAGR GDSREAPG*EGDEGTADPVRCTEEADGGYGNGGD GGPSHPGSGDQRGSG***CRWRVAAEV*AGCAG GGLHQETAPAGV*GQAGGGAAEQEAAGTAARGP AGR**GESAGSAAAQEEVPATDG*AARHQAAPGG PAGPQPRTGEEAEEV*Q*ALAGA*GGPAGEAAA GEAAAGEGHAPR*GFQPEAATRGKRHGHCRVHP EGCVSRGRAPGHFFPRVQG*GFSGQGQETAPGPG GQSQGSGRRAG*AGRDHPDAGTGQAASGDGDGA DETDPF*GDGESG*GGGGGPAVVSEEVKTDGGA ARGRV*GQAEGSAREAGAGGQARHPQRPGEPAGL *VREAAAEGPEAHQGPAGRCPAHAGPPEEQCSQ QARDCPAQEPAGGVRVHLCGSRESTESNGGGDR RPAPAD**HRQSQDSAGGAAEPPSA*EE*DPEPA GGRSGRHERIDEEAQGCRGSGFPGPGSDK*SPS SARRSQQREAGAAGEATSPPEPGGVPGAVHGGQ VPGEQAGS*DTGAGDTPGV*KDASETAGEPG*PS QGKHGEAD*GAGSAHCSREPGEGTEQAATEAAP GHQGGDGRACQEGGRGEPQEARTGDGSRKPGGC *PEPAG*PKVGIQAHRGPAGCH*G*DGE**E*GP HQQ*GRL*CGLGAGGPC*RGQVLVVKKQGTFQG SF**WQLKEFQPHQLLEVPCP*SVR**ARPSRQ HLQTAILPQLSE*QRHRGQADGD*RIAQGSGWQP SHPRACGCLGTSPRKWWGTGLPHPTADLHGKHP DLLLSGALSRLWVSDVSTWKRWGKEEFLKRTFC SSVSKCQTLGFYPVSPWAVAGGLALHGASTLTSL SAPCSGTVDRLPTGTL*VAGSMGRIGGGEAVPS LSCGVGALSSWCLLSFYFLI*IPNLSITAASLR VGGGCSGSWGSQERLGNVISIFTLQRAVLSLCSW RRW*GEPGPGS*E*GAEGLSGAAGLG*ASLRRQ VCVWTIRTSSPHPTLFVSACYVQ*PI*GKPIPT TAVQG*SKHCLPPALSRWSGP*TQLEREGLGLRT CDQKN*RWKFWPVLIRHESSLCVLSPCHSSNLP APTHLSQTQHHVVWRSQPPP*KGYP*ELHQTWE PKCSAWCCSHLPPPFSPAIGLYSLGCALPCLPDV WK*RPFSSWLRQ

Frame 2

HP*PGRGCWMPRLRFCCLPGGLRWPQQSGAPRP CAKHS*SSGGATPTNSTPTMFNLMKKDKDKDGG RKEKKEKKEKKERMSAAELRSLEEMSLRRGFFN LNRSSKRESKTRLEISNPIPIKVASGSDLHLTDI DSDSNRGSVILDSGHLSTASSSDDLKGEEGSFR GSVLQRAAKFGSLAKQNSQMIVKRFSFSQRSRD ESASETSTPSEHSAAPSPQVEVRTLEGQLVQHPG PGIPRPGHRSRAPELVTKKFPVDLRLPPVVPLP PPTLRELELQRRPTGDFGFSLRRTTMLDRGPEG QACRRVVHFAEPGAGTKDLALGLVPGDRLVEING HNVESKSRDEIVEMIRQSGDSVRLKVQPIPELS ELSRSWLRSGEGPRREPSDAKTEEQIAAEEAWN ETEKVWLVHRDGFSLASQLKSEELNLPEGKVRVK LDHDGAILDVDEDDVEKANAPSCDRLEDLASLV YLNESSVLHTLRQRYGASLLHTYAGPSLLVLGP RGAPAVYSEKVMHMFKGCRREDMAPHIYAVAQTA YRAMLMSRQDQSIILLGSSGSGKTTSCQHLVQY LATIAGISGNKVFSVEKWQALYTLLEAFGNSPT IINGNATRFSQILSLDFDQAGQVASASIQTMLLE KLRVARRPASEATFNVFYYLLACGDGTLRTELH LNHLAENNVFGIVPLAKPEEKQKAAQQFSKLQA AMKVLGISPDEQKACWFILAAIYHLGAAGATKEA AEAGRKQFARHEWAQKAAYLLGCSLEELSSAIF KHQHKGGTLQRSTSFRQGPEESGLGDGTGPKLS ALECLEGMAAGLYSELFTLLVSLVNRALKSSQHS LCSMMIVDTPGFQNPEQGGSARGASFEELCHNY TQDRLQRLFHERTFVQELERYKEENIELAFDDL EPPTDDSVAAVDQASHQSLVRSLARTDEARGLLW LLEEEALVPGASEDTLLERLFSYYGPQEGDKKG QSPLLHSSKPHHFLLGHSHGTNWVEYNVTGWLN YTKQNPATQNAPRLLQDSQKKIISNLFLGRAGSA TVLSGSIAGLEGGSQLALRRATSMRKTFTTGMA AVKKKSLCIQMKLQVDALIDTIKKSKLHFVHCF LPVAEGWAGEPRSASSRRVSSSSELDLPSGDHCE AGLLQLDVPLLRTQLRGSRLLDAMRMYRQGYPD HMVFSEFRRRFDVLAPHLTKKHGRNYIVVDERR AVEELLECLDLEKSSCCMGLSRVFFRAGTLARLE EQRDEQTSRNLTLFQAACRGYLARQHFKKRKIQ DLAIRCVQKNIKKNKGVKDWPWWKLFTTVRPLI EVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELR LNSDRLESRISELTSELTDERNTGESASQLLDA ETAERLRAEKEMKELQTQYDALKKQMEVMEMEV MEARLIRAAEINGEVDDDDAGGEWRLKYERAVRE VDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDL QADSEESQRALQQLKKKCQRLTAELQDTKLHLE GQQVRNHELEKKQRRFDSELSQAHEEAQREKLQR EKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQ KVVSLEAELQDISSQESKDEASLAKVKKQLRDL EAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMER MRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQ LEEEYEDKQKVLREKRELEGKLATLSDQVNRRD FESEKRLRKDLKRTKALLADAQLMLDHLKNSAPS KREIAQLKNQLEESEFTCAAAVKARKAMEVEIE DLHLQIDDIAKAKTALEEQLSRLQREKNEIQNR LEEDQEDMNELMKKHKAAVAQASRDLAQINDLQA QLEEANKEKQELQEKLQALQSQVEFLEQSMVDK SLVSRQEAKIRELETRLEFERTQVKRLESLASR LKENMEKLTEERDQRIAAENREKEQNKRLQRQLR DTKEEMGELARKEAEASRKKHELEMDLESLEAA NQSLQADLKLAFKRIGDLQAAIEDEMESDENED LINSEGDSDVDSELEDRVDGVKSWLSKNKGPSKA ASDDGSLKSSSPTSYWKSLAPDRSDDEHDPLDN TSRPRYSHSYLSDSDTEAKLTETNA*PRGVVGS PLTPGPVAAWAPLPGSGGAPVSPTRLLICMGNTL TFFCQGHFPGYGCLMSPRGRGGGKRSF*RELFA PLSQNARLLASTLCHRGQWQVAWHCMEPAR*PP SQLPAQGRWTGCLLGHSRLLGPWGGLGEEKQCLP SRVGWGLSLLGACCLSTF*FKYPTSPSQLHP*E WEGAVVVAGAPKNDSGMSSPSSPFREQSFLCAA GDAGEESRVQVLKNEVRRGSPVLLGWVEQAYADK CVCGPSAPPAPTPPSLSQRVMCNDLFKVNPFQL QQFRADPSTASLLLCPGGLDHKLNLRGKAWG*G LVIRKTEDGSFGRCSLDMSPHSVS*ARVILPTSL PPHTYPRHNTMWSGGPSPHPKKVIPENSTRLGS PSAVPGAAPICRPPSLLQLVCTHWAVLSPVYPM YGNKGPFPPGCAS

Sequence NM_078471

TCCATCCCTGACCGGGCCGAGGCTGCTGGATGCCGCGTCTCCGCTTCTGCTGCCTGCCGGGCGGGCTCCGGTGGCCGCAGCAAAGTGGGGCACCAAGGCC CTGTGCTAAGCACTCATAATCCTCTGGGGGTGCTACCCCTACAAACAGCACCCCCACCATGTTTAACCTAATGAAGAAAGACAAGGACAAAGATGGCGGG CGGAAGGAGAAGAAGGAGAAAAAGGAGAAAAAGGAGCGGATGTCAGCGGCAGAGCTTCGGAGCCTGGAGGAGATGAGCCTGCGACGTGGCTTCTTCAACC TGAACCGCTCCTCCAAGCGTGAATCCAAGACGCGCCTGGAAATCTCCAACCCCATCCCCATCAAGGTGGCCAGCGGCTCTGACCTGCACCTGACTGACAT TGACTCCGATAGTAACCGGGGCAGCGTCATCCTGGACTCGGGCCACCTAAGTACAGCCAGCTCCAGCGATGACCTCAAGGGTGAGGAGGGTAGCTTCCGT GGCTCGGTGCTGCAGCGGGCAGCCAAGTTCGGCTCACTGGCCAAGCAGAACTCACAGATGATTGTCAAGCGCTTTTCCTTCTCCCAGCGTAGCCGGGATG AGAGCGCCTCAGAAACCTCGACGCCCTCAGAGCACTCTGCCGCCCCCTCGCCACAGGTGGAGGTGAGGACTCTAGAGGGACAGCTGGTGCAGCATCCTGG CCCAGGCATCCCTCGACCAGGGCACCGATCCCGAGCCCCTGAGCTAGTGACTAAAAAGTTCCCAGTCGACCTGCGCCTGCCCCCCGTGGTGCCCCTGCCC CCACCTACCCTCCGGGAGCTGGAGCTGCAACGACGGCCCACTGGAGACTTTGGCTTCTCCCTGCGGCGCACAACCATGCTGGATCGGGGCCCCGAGGGCC AGGCCTGTCGGCGTGTGGTCCACTTTGCTGAGCCTGGTGCAGGCACCAAGGACCTGGCCCTGGGGCTGGTGCCAGGAGATCGACTGGTGGAGATTAATGG GCACAATGTGGAGAGCAAGTCCAGGGATGAGATTGTGGAGATGATCCGGCAGTCAGGGGACAGCGTGCGGCTCAAGGTGCAGCCCATTCCAGAGCTCAGC GAGCTCAGCAGGAGCTGGCTGCGGAGCGGCGAGGGACCTCGCAGGGAGCCATCCGATGCGAAAACAGAAGAACAGATTGCAGCAGAAGAGGCCTGGAATG AGACGGAGAAGGTGTGGCTGGTCCATAGGGACGGCTTCTCACTGGCCAGTCAACTCAAATCTGAGGAGCTCAACTTGCCTGAGGGGAAGGTGCGTGTGAA GCTGGACCACGATGGGGCCATCCTGGATGTGGATGAGGATGACGTTGAGAAGGCTAATGCTCCCTCCTGCGACCGTCTGGAGGATCTGGCCTCACTGGTG TACCTCAATGAGTCCAGCGTCCTGCACACCTTGCGCCAGCGCTATGGCGCTAGCCTGCTGCACACGTATGCTGGCCCCAGCCTGCTGGTTCTTGGCCCCC GTGGGGCCCCTGCTGTGTACTCTGAGAAGGTGATGCACATGTTCAAGGGTTGTCGGCGGGAGGACATGGCACCCCACATCTATGCAGTGGCCCAGACCGC ATACAGGGCGATGCTGATGAGCCGTCAGGATCAGTCAATCATCCTCCTGGGCAGTAGTGGCAGTGGCAAGACCACCAGCTGCCAGCATCTGGTGCAGTAC CTGGCCACCATCGCGGGCATCAGCGGGAACAAGGTGTTTTCTGTGGAGAAGTGGCAGGCTCTGTACACCCTCCTGGAAGCCTTTGGGAACAGCCCCACCA TCATTAATGGCAATGCCACCCGCTTCTCCCAGATCCTCTCCCTGGACTTTGACCAAGCTGGCCAGGTGGCCTCAGCCTCCATTCAGACAATGCTTCTGGA GAAGCTGCGTGTGGCTCGGCGCCCAGCCAGTGAAGCCACATTCAACGTCTTCTACTACCTGCTGGCCTGTGGGGATGGCACCCTCAGGACAGAGCTCCAC CTCAACCACTTGGCAGAGAACAATGTGTTTGGGATTGTGCCACTGGCCAAGCCTGAGGAAAAGCAGAAGGCAGCTCAGCAGTTTAGTAAGCTGCAGGCGG CCATGAAGGTGCTGGGCATCTCCCCCGATGAACAGAAGGCCTGCTGGTTCATTCTGGCTGCCATCTACCACCTGGGGGCTGCGGGAGCCACCAAAGAAGC TGCTGAAGCTGGGCGCAAGCAGTTTGCCCGCCATGAGTGGGCCCAGAAGGCTGCGTACCTACTGGGCTGCAGCCTGGAGGAGCTGTCCTCAGCCATCTTC AAGCACCAGCACAAGGGTGGCACCCTGCAGCGCTCCACCTCCTTCCGCCAGGGCCCCGAGGAGAGTGGCCTGGGAGATGGGACAGGCCCGAAACTGAGTG CACTGGAGTGCCTTGAGGGCATGGCGGCCGGCCTCTACAGCGAGCTCTTCACCCTTCTCGTCTCCCTGGTGAATAGGGCTCTCAAGTCCAGCCAGCACTC ACTCTGCTCCATGATGATTGTCGACACCCCGGGCTTCCAGAACCCTGAGCAGGGTGGGTCAGCCCGCGGAGCCTCCTTTGAGGAGCTGTGCCACAACTAC ACCCAAGACCGGCTGCAGAGGCTCTTCCACGAGCGCACCTTCGTGCAGGAGTTGGAAAGATACAAGGAGGAGAACATCGAGCTGGCGTTTGACGACTTGG AACCCCCGACGGATGACTCTGTGGCTGCTGTGGACCAGGCCTCCCATCAGTCCCTGGTCCGCTCGCTGGCCCGCACAGACGAGGCGAGGGGCCTGCTCTG GCTATTGGAAGAGGAGGCTCTGGTGCCAGGGGCCAGTGAGGACACCCTCCTGGAGCGCCTTTTCTCCTATTATGGCCCCCAGGAAGGTGACAAAAAAGGC CAAAGCCCCCTTCTGCACAGCAGCAAACCACACCACTTTCTCCTGGGCCACAGCCATGGCACCAACTGGGTAGAGTACAATGTGACTGGCTGGCTGAACT ACACCAAGCAGAACCCAGCCACCCAGAATGCCCCCCGGCTCCTGCAGGACTCCCAGAAAAAAATCATCAGCAACCTGTTTCTGGGCCGCGCAGGCAGTGC CACGGTGCTCTCTGGCTCCATCGCGGGCCTGGAGGGCGGCTCGCAGCTGGCACTGCGCCGGGCCACCAGCATGCGGAAAACCTTTACCACAGGCATGGCG GCTGTCAAAAAGAAGTCACTGTGCATCCAGATGAAGCTACAGGTGGACGCCCTCATCGACACCATCAAGAAGTCAAAGCTGCATTTTGTGCACTGCTTCC TGCCTGTAGCTGAGGGCTGGGCTGGGGAGCCCCGTTCCGCCTCCTCCCGCCGAGTCAGCAGCAGCAGTGAGCTGGACCTGCCCTCGGGAGACCACTGCGA GGCTGGGCTCCTGCAGCTCGACGTGCCCCTGCTCCGCACCCAGCTCCGCGGCTCCCGCCTGCTCGATGCCATGCGCATGTACCGCCAAGGTTACCCTGAC CACATGGTGTTTTCCGAGTTCCGCCGCCGCTTTGATGTCCTGGCCCCGCACCTGACCAAGAAACACGGGCGTAACTACATCGTGGTGGATGAAAGGCGGG CAGTGGAGGAGCTGCTGGAGTGCTTGGATCTGGAGAAGAGCAGCTGCTGCATGGGCCTGAGCCGGGTGTTCTTCCGGGCGGGCACCTTGGCACGGCTGGA GGAGCAGCGGGATGAACAAACCAGCAGGAACCTAACCCTGTTCCAAGCAGCCTGCAGGGGCTACCTGGCCCGCCAGCACTTCAAGAAGAGAAAGATCCAG GACCTGGCCATTCGCTGTGTACAGAAGAACATCAAGAAGAACAAAGGGGTGAAGGACTGGCCCTGGTGGAAGCTTTTTACCACAGTGAGGCCCCTCATCG AAGTACAGCTGTCAGAGGAGCAGATCCGGAACAAAGACGAGGAGATCCAGCAGCTGCGGAGCAAGCTCGAGAAGGCGGAGAAGGAGAGGAACGAGCTGCG GCTCAACAGTGACCGGCTGGAGAGCCGGATCTCAGAGCTGACATCGGAGCTGACAGATGAGCGTAACACAGGAGAGTCCGCCTCCCAGCTGCTGGACGCG GAGACAGCAGAGAGGCTCCGGGCTGAGAAGGAGATGAAGGAACTGCAGACCCAGTACGATGCACTGAAGAAGCAGATGGAGGTTATGGAAATGGAGGTGA TGGAGGCCCGTCTCATCCGGGCAGCGGAGATCAACGGGGAAGTGGATGATGATGATGCAGGTGGCGAGTGGCGGCTGAAGTATGAGCGGGCTGTGCGGGA GGTGGACTTCACCAAGAAACGGCTCCAGCAGGAGTTTGAGGACAAGCTGGAGGTGGAGCAGCAGAACAAGAGGCAGCTGGAACGGCGGCTCGGGGACCTG CAGGCAGATAGTGAGGAGAGTCAGCGGGCTCTGCAGCAGCTCAAGAAGAAGTGCCAGCGACTGACGGCTGAGCTGCAAGACACCAAGCTGCACCTGGAGG GCCAGCAGGTCCGCAACCACGAACTGGAGAAGAAGCAGAGGAGGTTTGACAGTGAGCTCTCGCAGGCGCATGAGGAGGCCCAGCGGGAGAAGCTGCAGCG GGAGAAGCTGCAGCGGGAGAAGGACATGCTCCTCGCTGAGGCTTTCAGCCTGAAGCAGCAACTAGAGGAAAAAGACATGGACATTGCAGGGTTCACCCAG AAGGTTGTGTCTCTAGAGGCAGAGCTCCAGGACATTTCTTCCCAAGAGTCCAAGGATGAGGCTTCTCTGGCCAAGGTCAAGAAACAGCTCCGGGACCTGG AGGCCAAAGTCAAGGATCAGGAAGAAGAGCTGGATGAGCAGGCAGGGACCATCCAGATGCTGGAACAGGCCAAGCTGCGTCTGGAGATGGAGATGGAGCG GATGAGACAGACCCATTCTAAGGAGATGGAGAGTCGGGATGAGGAGGTGGAGGAGGCCCGGCAGTCGTGTCAGAAGAAGTTAAAACAGATGGAGGTGCAG CTAGAGGAAGAGTATGAGGACAAGCAGAAGGTTCTGCGAGAGAAGCGGGAGCTGGAGGGCAAGCTCGCCACCCTCAGCGACCAGGTGAACCGGCGGGACT TTGAGTCAGAGAAGCGGCTGCGGAAGGACCTGAAGCGCACCAAGGCCCTGCTGGCAGATGCCCAGCTCATGCTGGACCACCTGAAGAACAGTGCTCCCAG CAAGCGAGAGATTGCCCAGCTCAAGAACCAGCTGGAGGAGTCAGAGTTCACCTGTGCGGCAGCCGTGAAAGCACGGAAAGCAATGGAGGTGGAGATCGAA GACCTGCACCTGCAGATTGATGACATCGCCAAAGCCAAGACAGCGCTGGAGGAGCAGCTGAGCCGCCTTCAGCGTGAGAAGAATGAGATCCAGAACCGGC TGGAGGAAGATCAGGAAGACATGAACGAATTGATGAAGAAGCACAAGGCTGCCGTGGCTCAGGCTTCCCGGGACCTGGCTCAGATAAATGATCTCCAAGC TCAGCTAGAAGAAGCCAACAAAGAGAAGCAGGAGCTGCAGGAGAAGCTACAAGCCCTCCAGAGCCAGGTGGAGTTCCTGGAGCAGTCCATGGTGGACAAG TCCCTGGTGAGCAGGCAGGAAGCTAAGATACGGGAGCTGGAGACACGCCTGGAGTTTGAAAGGACGCAAGTGAAACGGCTGGAGAGCCTGGCTAGCCGTC TCAAGGAAAACATGGAGAAGCTGACTGAGGAGCGGGATCAGCGCATTGCAGCCGAGAACCGGGAGAAGGAACAGAACAAGCGGCTACAGAGGCAGCTCCG GGACACCAAGGAGGAGATGGGCGAGCTTGCCAGGAAGGAGGCCGAGGCGAGCCGCAAGAAGCACGAACTGGAGATGGATCTAGAAAGCCTGGAGGCTGCT AACCAGAGCCTGCAGGCTGACCTAAAGTTGGCATTCAAGCGCATCGGGGACCTGCAGGCTGCCATTGAGGATGAGATGGAGAGTGATGAGAATGAGGACC TCATCAACAGTTTGCAGGACATGGTGACAAAGTATCAGAAAAGAAAGAATAAACTTGAGGGAGACTCTGATGTGGACTCGGAGCTGGAGGACCGTGTTGA CGGGGTCAAGTCCTGGTTGTCAAAAAACAAGGGACCTTCCAAGGCAGCTTCTGATGATGGCAGCTTAAAGAGTTCCAGCCCCACCAGCTACTGGAAGTCC CTTGCCCCTGATCGGTCAGATGATGAGCACGACCCTCTCGACAACACCTCCAGACCGCGATACTCCCACAGTTATCTGAGTGACAGCGACACAGAGGCCA AGCTGACGGAGACTAACGCATAGCCCAGGGGAGTGGTTGGCAGCCCTCTCACCCCAGGGCCTGTGGCTGCCTGGGCACCTCTCCCAGGAAGTGGTGGGGC ACCGGTCTCCCCCACCCGACTGCTGATCTGCATGGGAAACACCCTGACCTTCTTCTGTCAGGGGCACTTTCCAGGCTATGGGTGTCTGATGTCTCCACGT GGAAGAGGTGGGGGAAAGAGGAGTTTCTGAAGAGAACTTTTTGCTCCTCTGTCTCAAAATGCCAGACTCTTGGCTTCTACCCTGTGTCACCGTGGGCAGT GGCAGGTGGCCTGGCACTGCATGGAGCCAGCACGTTGACCTCCCTCTCAGCTCCCTGCTCAGGGACGGTGGACAGGTTGCCTACTGGGACACTCTAGGTT GCTGGGTCCATGGGGAGGATTGGGGGAGGAGAAGCAGTGCCTTCCCTCTCGTGTGGGGTGGGGGCTCTCTCTTCTTGGTGCCTGCTGTCTTTCTACTTTT TAATTTAAATACCCAACCTCTCCATCACAGCTGCATCCCTGAGAGTGGGAGGGGGCTGTAGTGGTAGCTGGGGCTCCCAAGAACGACTCGGGAATGTCAT CTCCATCTTCACCCTTCAGAGAGCAGTCCTTTCTCTGTGCAGCTGGAGACGCTGGTGAGGAGAGCCGGGTCCAGGTTCTTAAGAATGAGGTGCGGAGGGG CTCTCCGGTGCTGCTGGGCTGGGTTGAGCAAGCCTACGCAGACAAGTGTGTGTGTGGACCATCCGCACCTCCAGCCCCCACCCCACCCTCTTTGTCTCAG CGTGTTATGTGCAATGACCTATTTAAGGTAAACCCATTCCAACTACAGCAGTTCAGGGCTGATCCAAGCACTGCCTCCCTCCTGCTCTGTCCAGGTGGTC TGGACCATAAACTCAACTTGAGAGGGAAGGCTTGGGGTTGAGGACTTGTGATCAGAAAAACTGAAGATGGAAGTTTTGGCCGGTGCTCATTAGACATGAG TCCTCACTCTGTGTCCTGAGCCCGTGTCATTCTTCCAACCTCCCTGCCCCCACACACTTATCCCAGACACAACACCATGTGGTCTGGAGGTCCCAGCCCC CACCCTAAAAAGGTTATCCCTGAGAACTCCACCAGACTTGGGAGCCCAAGTGCAGTGCCTGGTGCTGCTCCCATCTGCCGCCCCCCTTCTCTCCTGCAAT TGGTTTGTACTCACTGGGCTGTGCTCTCCCCTGTTTACCCGATGTATGGAAATAAAGGCCCTTTTCCTCCTGGCTGCGCCAGT

refseq_MYO18A.F2 (forward primer)
refseq_MYO18A.R2 (reverse primer)
Single exon skipping

Frame 0

SIPDRAEAAGCRVSASAACRAGSGGRSKVGHQG PVLSTHNPLGVLPLQTAPPPCLT**RKTRTKMAG GRRRRRKRRKRSGCQRQSFGAWRR*ACDVASST *TAPPSVNPRRAWKSPTPSPSRWPAALTCT*LT LTPIVTGAASSWTRAT*VQPAPAMTSRVRRVASV ARCCSGQPSSAHWPSRTHR*LSSAFPSPSVAGM RAPQKPRRPQSTLPPPRHRWR*GL*RDSWCSIL AQASLDQGTDPEPLS**LKSSQSTCACPPWCPCP HLPSGSWSCNDGPLETLASPCGAQPCWIGAPRA RPVGVWSTLLSLVQAPRTWPWGWCQEIDWWRLM GTMWRASPGMRLWR*SGSQGTACGSRCSPFQSSA SSAGAGCGAARDLAGSHPMRKQKNRLQQKRPGM RRRRCGWSIGTASHWPVNSNLRSSTCLRGRCV* SWTTMGPSWMWMRMTLRRLMLPPATVWRIWPHWC TSMSPASCTPCASAMALACCTRMLAPACWFLAP VGPLLCTLRR*CTCSRVVGGRTWHPTSMQWPRP HTGRC**AVRISQSSSWAVVAVARPPAASIWCST WPPSRASAGTRCFLWRSGRLCTPSWKPLGTAPP SLMAMPPASPRSSPWTLTKLARWPQPPFRQCFW RSCVWLGAQPVKPHSTSSTTCWPVGMAPSGQSST STTWQRTMCLGLCHWPSLRKSRRQLSSLVSCRR P*RCWASPPMNRRPAGSFWLPSTTWGLREPPKK LLKLGASSLPAMSGPRRLRTYWAAAWRSCPQPSS STSTRVAPCSAPPPSARAPRRVAWEMGQARN*V HWSALRAWRPASTASSSPFSSPW*IGLSSPAST HSAP**LSTPRASRTLSRVGQPAEPPLRSCATTT PKTGCRGSSTSAPSCRSWKDTRRRTSSWRLTTW NPRRMTLWLLWTRPPISPWSARWPAQTRRGACS GYWKRRLWCQGPVRTPSWSAFSPIMAPRKVTKKA KAPFCTAANHTTFSWATAMAPTG*STM*LAG*T TPSRTQPPRMPPGSCRTPRKKSSATCFWAAQAV PRCSLAPSRAWRAARSWHCAGPPACGKPLPQAWR LSKRSHCASR*SYRWTPSSTPSRSQSCILCTAS CL*LRAGLGSPVPPPPAESAAAVSWTCPRETTA RLGSCSSTCPCSAPSSAAPACSMPCACTAKVTLT TWCFPSSAAALMSWPRT*PRNTGVTTSWWMKGG QWRSCWSAWIWRRAAAAWA*AGCSSGRAPWHGW RSSGMNKPAGT*PCSKQPAGATWPASTSRRERSR TWPFAVYRRTSRRTKG*RTGPGGSFLPQ*GPSS KYSCQRSRSGTKTRRSSSCGASSRRRRRRGTSC GSTVTGWRAGSQS*HRS*QMSVTQESPPPSCWTR RQQRGSGLRRR*RNCRPSTMH*RSRWRLWKWR* WRPVSSGQRRSTGKWMMMMQVASGG*SMSGLCG RWTSPRNGSSRSLRTSWRWSSRTRGSWNGGSGTC RQIVRRVSGLCSSSRRSASD*RLSCKTPSCTWR ASRSATTNWRRSRGGLTVSSRRRMRRPSGRSCS GRSCSGRRTCSSLRLSA*SSN*RKKTWTLQGSPR RLCL*RQSSRTFLPKSPRMRLLWPRSRNSSGTW RPKSRIRKKSWMSRQGPSRCWNRPSCVWRWRWS G*DRPILRRWRVGMRRWRRPGSRVRRS*NRWRCS *RKSMRTSRRFCERSGSWRASSPPSATR*TGGT LSQRSGCGRT*SAPRPCWQMPSSCWTT*RTVLP ASERLPSSRTSWRSQSSPVRQP*KHGKQWRWRSK TCTCRLMTSPKPRQRWRSS*AAFSVRRMRSRTG WRKIRKT*TN**RSTRLPWLRLPGTWLR*MISK LS*KKPTKRSRSCRRSYKPSRARWSSWSSPWWTS PW*AGRKLRYGSWRHAWSLKGRK*NGWRAWLAV SRKTWRS*LRSGISALQPRTGRRNRTSGYRGSS GTPRRRWASLPGRRPRRAARSTNWRWI*KAWRLL TRACRLT*SWHSSASGTCRLPLRMRWRVMRMRT SSTVCRTW*QSIRKERINLRETLMWTRSWRTVL TGSSPGCQKTRDLPRQLLMMAA*RVPAPPATGSP LPLIGQMMSTTLSTTPPDRDTPTVI*VTATQRP S*RRLTHSPGEWLAALSPQGLWLPGHLSQEVVG HRSPPPDC*SAWETP*PSSVRGTFQAMGV*CLHV EEVGERGVSEENFLLLCLKMPDSWLLPCVTVGS GRWPGTAWSQHVDLPLSSLLRDGGQVAYWDTLG CWVHGEDWGRRSSAFPLVWGGGSLFLVPAVFLLF NLNTQPLHHSCIPESGRGL*W*LGLPRTTRECH LHLHPSESSPFSVQLETLVRRAGSRFLRMRCGG ALRCCWAGLSKPTQTSVCVDHPHLQPPPHPLCLS VLCAMTYLR*THSNYSSSGLIQALPPSCSVQVV WTINST*EGRLGVEDL*SEKLKMEVLAGAH*T* VLTLCPEPVSFFQPPCPHTLIPDTTPCGLEVPAP TLKRLSLRTPPDLGAQVQCLVLLPSAAPLLSCN WFVLTGLCSPLFTRCMEIKALFLLAAP

Frame 1

PSLTGPRLLDAASPLLLPAGRAPVAAAKWGTKA LC*ALIILWGCYPYKQHPHHV*PNEERQGQRWR AEGEEGEKGEKGADVSGRASEPGGDEPATWLLQP EPLLQA*IQDAPGNLQPHPHQGGQRL*PAPD*H *LR**PGQRHPGLGPPKYSQLQR*PQG*GG*LP WLGAAAGSQVRLTGQAELTDDCQALFLLPA*PG* ERLRNLDALRALCRPLATGGGEDSRGTAGAASW PRHPSTRAPIPSP*ASD*KVPSRPAPAPRGAPA PTYPPGAGAATTAHWRLWLLPAAHNHAGSGPRGP GLSACGPLC*AWCRHQGPGPGAGARRSTGGD*W AQCGEQVQG*DCGDDPAVRGQRAAQGAAHSRAQ RAQQELAAERRGTSQGAIRCENRRTDCSRRGLE* DGEGVAGP*GRLLTGQSTQI*GAQLA*GEGACE AGPRWGHPGCG*G*R*EG*CSLLRPSGGSGLTG VPQ*VQRPAHLAPALWR*PAAHVCWPQPAGSWPP WGPCCVL*EGDAHVQGLSAGGHGTPHLCSGPDR IQGDADEPSGSVNHPPGQ*WQWQDHQLPASGAV PGHHRGHQREQGVFCGEVAGSVHPPGSLWEQPHH H*WQCHPLLPDPLPGL*PSWPGGLSLHSDNASG EAACGSAPSQ*SHIQRLLLPAGLWGWHPQDRAP PQPLGREQCVWDCATGQA*GKAEGSSAV**AAGG HEGAGHLPR*TEGLLVHSGCHLPPGGCGSHQRS C*SWAQAVCPP*VGPEGCVPTGLQPGGAVLSHL QAPAQGWHPAALHLLPPGPRGEWPGRWDRPETEC TGVP*GHGGRPLQRALHPSRLPGE*GSQVQPAL TLLHDDCRHPGLPEP*AGWVSPRSLL*GAVPQL HPRPAAEALPRAHLRAGVGKIQGGEHRAGV*RLG TPDG*LCGCCGPGLPSVPGPLAGPHRRGEGPAL AIGRGGSGARGQ*GHPPGAPFLLLWPPGR*QKR PKPPSAQQQTTPLSPGPQPWHQLGRVQCDWLAEL HQAEPSHPECPPAPAGLPEKNHQQPVSGPRRQC HGALWLHRGPGGRLAAGTAPGHQHAENLYHRHG GCQKEVTVHPDEATGGRPHRHHQEVKAAFCALLP ACS*GLGWGAPFRLLPPSQQQQ*AGPALGRPLR GWAPAARRAPAPHPAPRLPPARCHAHVPPRLP* PHGVFRVPPPL*CPGPAPDQETRA*LHRGG*KAG SGGAAGVLGSGEEQLLHGPEPGVLPGGHLGTAG GAAG*TNQQEPNPVPSSLQGLPGPPALQEEKDP GPGHSLCTEEHQEEQRGEGLALVEAFYHSEAPHR STAVRGADPEQRRGDPAAAEQAREGGEGEERAA AQQ*PAGEPDLRADIGADR*A*HRRVRLPAAGR GDSREAPG*EGDEGTADPVRCTEEADGGYGNGGD GGPSHPGSGDQRGSG***CRWRVAAEV*AGCAG GGLHQETAPAGV*GQAGGGAAEQEAAGTAARGP AGR**GESAGSAAAQEEVPATDG*AARHQAAPGG PAGPQPRTGEEAEEV*Q*ALAGA*GGPAGEAAA GEAAAGEGHAPR*GFQPEAATRGKRHGHCRVHP EGCVSRGRAPGHFFPRVQG*GFSGQGQETAPGPG GQSQGSGRRAG*AGRDHPDAGTGQAASGDGDGA DETDPF*GDGESG*GGGGGPAVVSEEVKTDGGA ARGRV*GQAEGSAREAGAGGQARHPQRPGEPAGL *VREAAAEGPEAHQGPAGRCPAHAGPPEEQCSQ QARDCPAQEPAGGVRVHLCGSRESTESNGGGDR RPAPAD**HRQSQDSAGGAAEPPSA*EE*DPEPA GGRSGRHERIDEEAQGCRGSGFPGPGSDK*SPS SARRSQQREAGAAGEATSPPEPGGVPGAVHGGQ VPGEQAGS*DTGAGDTPGV*KDASETAGEPG*PS QGKHGEAD*GAGSAHCSREPGEGTEQAATEAAP GHQGGDGRACQEGGRGEPQEARTGDGSRKPGGC *PEPAG*PKVGIQAHRGPAGCH*G*DGE**E*GP HQQFAGHGDKVSEKKE*T*GRL*CGLGAGGPC* RGQVLVVKKQGTFQGSF**WQLKEFQPHQLLEV PCP*SVR**ARPSRQHLQTAILPQLSE*QRHRGQ ADGD*RIAQGSGWQPSHPRACGCLGTSPRKWWG TGLPHPTADLHGKHPDLLLSGALSRLWVSDVST WKRWGKEEFLKRTFCSSVSKCQTLGFYPVSPWAV AGGLALHGASTLTSLSAPCSGTVDRLPTGTL*V AGSMGRIGGGEAVPSLSCGVGALSSWCLLSFYF LI*IPNLSITAASLRVGGGCSGSWGSQERLGNVI SIFTLQRAVLSLCSWRRW*GEPGPGS*E*GAEG LSGAAGLG*ASLRRQVCVWTIRTSSPHPTLFVS ACYVQ*PI*GKPIPTTAVQG*SKHCLPPALSRWS GP*TQLEREGLGLRTCDQKN*RWKFWPVLIRHE SSLCVLSPCHSSNLPAPTHLSQTQHHVVWRSQP PP*KGYP*ELHQTWEPKCSAWCCSHLPPPFSPAI GLYSLGCALPCLPDVWK*RPFSSWLRQ

Frame 2

HP*PGRGCWMPRLRFCCLPGGLRWPQQSGAPRP CAKHS*SSGGATPTNSTPTMFNLMKKDKDKDGG RKEKKEKKEKKERMSAAELRSLEEMSLRRGFFN LNRSSKRESKTRLEISNPIPIKVASGSDLHLTDI DSDSNRGSVILDSGHLSTASSSDDLKGEEGSFR GSVLQRAAKFGSLAKQNSQMIVKRFSFSQRSRD ESASETSTPSEHSAAPSPQVEVRTLEGQLVQHPG PGIPRPGHRSRAPELVTKKFPVDLRLPPVVPLP PPTLRELELQRRPTGDFGFSLRRTTMLDRGPEG QACRRVVHFAEPGAGTKDLALGLVPGDRLVEING HNVESKSRDEIVEMIRQSGDSVRLKVQPIPELS ELSRSWLRSGEGPRREPSDAKTEEQIAAEEAWN ETEKVWLVHRDGFSLASQLKSEELNLPEGKVRVK LDHDGAILDVDEDDVEKANAPSCDRLEDLASLV YLNESSVLHTLRQRYGASLLHTYAGPSLLVLGP RGAPAVYSEKVMHMFKGCRREDMAPHIYAVAQTA YRAMLMSRQDQSIILLGSSGSGKTTSCQHLVQY LATIAGISGNKVFSVEKWQALYTLLEAFGNSPT IINGNATRFSQILSLDFDQAGQVASASIQTMLLE KLRVARRPASEATFNVFYYLLACGDGTLRTELH LNHLAENNVFGIVPLAKPEEKQKAAQQFSKLQA AMKVLGISPDEQKACWFILAAIYHLGAAGATKEA AEAGRKQFARHEWAQKAAYLLGCSLEELSSAIF KHQHKGGTLQRSTSFRQGPEESGLGDGTGPKLS ALECLEGMAAGLYSELFTLLVSLVNRALKSSQHS LCSMMIVDTPGFQNPEQGGSARGASFEELCHNY TQDRLQRLFHERTFVQELERYKEENIELAFDDL EPPTDDSVAAVDQASHQSLVRSLARTDEARGLLW LLEEEALVPGASEDTLLERLFSYYGPQEGDKKG QSPLLHSSKPHHFLLGHSHGTNWVEYNVTGWLN YTKQNPATQNAPRLLQDSQKKIISNLFLGRAGSA TVLSGSIAGLEGGSQLALRRATSMRKTFTTGMA AVKKKSLCIQMKLQVDALIDTIKKSKLHFVHCF LPVAEGWAGEPRSASSRRVSSSSELDLPSGDHCE AGLLQLDVPLLRTQLRGSRLLDAMRMYRQGYPD HMVFSEFRRRFDVLAPHLTKKHGRNYIVVDERR AVEELLECLDLEKSSCCMGLSRVFFRAGTLARLE EQRDEQTSRNLTLFQAACRGYLARQHFKKRKIQ DLAIRCVQKNIKKNKGVKDWPWWKLFTTVRPLI EVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELR LNSDRLESRISELTSELTDERNTGESASQLLDA ETAERLRAEKEMKELQTQYDALKKQMEVMEMEV MEARLIRAAEINGEVDDDDAGGEWRLKYERAVRE VDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDL QADSEESQRALQQLKKKCQRLTAELQDTKLHLE GQQVRNHELEKKQRRFDSELSQAHEEAQREKLQR EKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQ KVVSLEAELQDISSQESKDEASLAKVKKQLRDL EAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMER MRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQ LEEEYEDKQKVLREKRELEGKLATLSDQVNRRD FESEKRLRKDLKRTKALLADAQLMLDHLKNSAPS KREIAQLKNQLEESEFTCAAAVKARKAMEVEIE DLHLQIDDIAKAKTALEEQLSRLQREKNEIQNR LEEDQEDMNELMKKHKAAVAQASRDLAQINDLQA QLEEANKEKQELQEKLQALQSQVEFLEQSMVDK SLVSRQEAKIRELETRLEFERTQVKRLESLASR LKENMEKLTEERDQRIAAENREKEQNKRLQRQLR DTKEEMGELARKEAEASRKKHELEMDLESLEAA NQSLQADLKLAFKRIGDLQAAIEDEMESDENED LINSLQDMVTKYQKRKNKLEGDSDVDSELEDRVD GVKSWLSKNKGPSKAASDDGSLKSSSPTSYWKS LAPDRSDDEHDPLDNTSRPRYSHSYLSDSDTEA KLTETNA*PRGVVGSPLTPGPVAAWAPLPGSGGA PVSPTRLLICMGNTLTFFCQGHFPGYGCLMSPR GRGGGKRSF*RELFAPLSQNARLLASTLCHRGQ WQVAWHCMEPAR*PPSQLPAQGRWTGCLLGHSRL LGPWGGLGEEKQCLPSRVGWGLSLLGACCLSTF *FKYPTSPSQLHP*EWEGAVVVAGAPKNDSGMS SPSSPFREQSFLCAAGDAGEESRVQVLKNEVRRG SPVLLGWVEQAYADKCVCGPSAPPAPTPPSLSQ RVMCNDLFKVNPFQLQQFRADPSTASLLLCPGG LDHKLNLRGKAWG*GLVIRKTEDGSFGRCSLDMS PHSVS*ARVILPTSLPPHTYPRHNTMWSGGPSP HPKKVIPENSTRLGSPSAVPGAAPICRPPSLLQ LVCTHWAVLSPVYPMYGNKGPFPPGCAS