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Sequences

Sequence NM_147233

TTCCAGTTACAGCTATATCAGAGAATGAGTTAATCTCCTCAGAAATCACTAAATACTACTCTGAGGGGCTTAGAAATTAACAGGTTGTTTATATAATTGG CCTTAAATGAGGTGAGAGTGAAGAGACTAGAGCCATCTCTGGAAAACATCATTATCCCATTCCCCGGGAAGCTACCCTCTGGAACTCAAGATTTGACCAT ATCTGTTTTGAGGATTCATTATGAACAAAGAAGTCTCCCAGGTGTGAAGTTTTTCAACATGAGTGGCCTCGGGGACAGTTCATCCGACCCTGCTAACCCA GACTCACATAAGAGGAAAGGATCGCCATGTGACACACTGGCATCAAGCACGGAAAAGAGGCGCAGGGAGCAAGAAAATAAATATTTAGAAGAACTAGCTG AGTTACTGTCTGCCAACATTAGTGACATTGACAGCTTGAGTGTAAAACCAGACAAATGCAAGATTTTGAAGAAAACAGTCGATCAGATACAGCTAATGAA GAGAATGGAACAAGAGAAATCAACAACTGATGACGATGTACAGAAATCAGACATCTCATCAAGTAGTCAAGGAGTGATAGAAAAGGAATCCTTGGGACCT CTTCTTTTGGAGGCTTTGGATGGATTTTTCTTTGTTGTGAACTGTGAAGGGAGAATTGTATTTGTGTCAGAGAATGTAACCAGCTACTTAGGTTACAATC AGGAGGAATTAATGAATACGAGCGTCTACAGCATACTGCACGTGGGGGATCATGCAGAATTTGTGAAGAATCTGCTACCAAAATCACTAGTAAATGGAGT TCCTTGGCCTCAAGAGGCAACACGACGAAATAGCCATACCTTTAACTGCAGGATGCTAATTCACCCTCCAGATGAGCCAGGGACCGAGAACCAAGAAGCT TGCCAGCGTTATGAAGTAATGCAGTGTTTCACTGTGTCACAGCCAAAATCAATTCAAGAGGATGGAGAAGATTTCCAGTCATGTCTGATTTGTATTGCAC GGCGATTACCTCGGCCTCCAGCTATTACGGGTGTAGAATCCTTTATGACCAAGCAAGATACTACAGGTAAAATCATCTCTATTGATACTAGTTCCCTGAG AGCTGCTGGCAGAACTGGTTGGGAAGATTTAGTGAGGAAGTGCATTTATGCTTTTTTCCAACCTCAGGGCAGAGAACCATCTTATGCCAGACAGCTGTTC CAAGAAGTGATGACTCGTGGCACTGCCTCCAGCCCCTCCTATAGATTCATATTGAATGATGGGACAATGCTTAGCGCCCACACCAAGTGTAAACTTTGCT ACCCTCAAAGTCCAGACATGCAACCTTTCATCATGGGAATTCATATCATCGACAGGGAGCACAGTGGGCTTTCTCCTCAAGATGACACTAATTCTGGAAT GTCAATTCCCCGAGTAAATCCCTCGGTCAATCCTAGTATCTCTCCAGCTCATGGTGTGGCTCGTTCATCCACATTGCCACCATCCAACAGCAACATGGTA TCCACCAGAATAAACCGCCAGCAGAGCTCAGACCTTCATAGCAGCAGTCATAGTAATTCTAGCAACAGCCAAGGAAGTTTCGGATGCTCACCCGGAAGTC AGATTGTAGCCAATGTTGCCTTAAACCAAGGACAGGCCAGTTCACAGAGCAGTAATCCCTCTTTAAACCTCAATAATTCTCCTATGGAAGGTACAGGAAT ATCCCTAGCACAGTTCATGTCTCCAAGGAGACAGGTTACTTCTGGATTGGCAACAAGGCCCAGGATGCCAAACAATTCCTTTCCTCCTAATATTTCGACA TTAAGCTCTCCCGTTGGCATGACAAGTAGTGCCTGTAATAATAATAACCGATCTTATTCAAACATCCCAGTAACATCTTTACAGGGTATGAATGAAGGAC CCAATAACTCCGTTGGCTTCTCTGCCAGTTCTCCAGTCCTCAGGCAGATGAGCTCACAGAATTCACCTAGCAGATTAAATATACAACCAGCAAAAGCTGA GTCCAAAGATAACAAAGAGATTGCCTCAATTTTAAATGAAATGATTCAATCTGACAACAGCTCTAGTGATGGCAAACCTCTGGATTCAGGGCTTCTGCAT AACAATGACAGACTTTCAGATGGAGACAGTAAATACTCTCAAACCAGTCACAAACTAGTGCAGCTTTTGACAACAACTGCCGAACAGCAGTTACGGCATG CTGATATAGACACAAGCTGCAAAGATGTCCTGTCTTGCACAGGCACTTCCAACTCTGCCTCTGCTAACTCTTCAGGAGGTTCTTGTCCCTCTTCTCATAG CTCATTGACAGAACGGCATAAAATTCTACACCGGCTCTTACAGGAGGGTAGCCCCTCAGATATCACCACTTTGTCTGTCGAGCCTGATAAAAAGGACAGT GCATCTACTTCTGTGTCAGTGACTGGACAGGTACAAGGAAACTCCAGTATAAAACTAGAACTGGATGCTTCAAAGAAAAAAGAATCAAAAGACCATCAGC TCCTACGCTATCTTTTAGATAAAGATGAGAAAGATTTAAGATCAACTCCAAACCTGAGCCTGGATGATGTAAAGGTGAAAGTGGAAAAGAAAGAACAGAT GGATCCATGTAATACAAACCCAACCCCAATGACCAAACCCACTCCTGAGGAAATAAAACTGGAGGCCCAGAGCCAGTTTACAGCTGACCTTGACCAGTTT GATCAGTTACTGCCCACGCTGGAGAAGGCAGCACAGTTGCCAGGCTTATGTGAGACAGACAGGATGGATGGTGCGGTCACCAGTGTAACCATCAAATCGG AGATCCTGCCAGCTTCACTTCAGTCCGCCACTGCCAGACCCACTTCCAGGCTAAATAGATTACCTGAGCTGGAATTGGAAGCAATTGATAACCAATTTGG ACAACCAGGAACAGGCGATCAGATTCCATGGACAAATAATACAGTGACAGCTATAAATCAGAGTAAATCAGAAGACCAGTGTATTAGCTCACAATTAGAT GAGCTTCTCTGTCCACCCACAACAGTAGAAGGGAGAAATGATGAGAAGGCTCTTCTTGAACAGCTGGTATCCTTCCTTAGTGGCAAAGATGAAACTGAGC TAGCTGAACTAGACAGAGCTCTGGGAATTGACAAACTTGTTCAGGGGGGTGGATTAGATGTATTATCAGAGAGATTTCCACCACAACAAGCAACGCCACC TTTGATCATGGAAGAAAGACCCAACCTTTATTCCCAGCCTTACTCTTCTCCTTCTCCTACTGCCAATCTCCCTAGCCCTTTCCAAGGCATGGTCAGGCAA AAACCTTCACTGGGGACGATGCCTGTTCAAGTAACACCTCCCCGAGGTGCTTTTTCACCTGGCATGGGCATGCAGCCCAGGCAAACTCTAAACAGACCTC CGGCTGCACCTAACCAGCTTCGACTTCAACTACAGCAGCGATTACAGGGACAACAGCAGTTGATACACCAAAATCGGCAAGCTATCTTAAACCAGTTTGC AGCAACTGCTCCTGTTGGCATCAATATGAGATCAGGCATGCAACAGCAAATTACACCTCAGCCACCCCTGAATGCTCAAATGTTGGCACAACGTCAGCGG GAACTGTACAGTCAACAGCACCGACAGAGGCAGCTAATACAGCAGCAAAGAGCCATGCTTATGAGGCAGCAAAGCTTTGGGAACAACCTCCCTCCCTCAT CTGGACTACCAGTTCAAATGGGGAACCCCCGTCTTCCTCAGGGTGCTCCACAGCAATTCCCCTATCCACCAAACTATGGTACAAATCCAGGAACCCCACC TGCTTCTACCAGCCCGTTTTCACAACTAGCAGCAAATCCTGAAGCATCCTTGGCCAACCGCAACAGCATGGTGAGCAGAGGCATGACAGGAAACATAGGA GGACAGTTTGGCACTGGAATCAATCCTCAGATGCAGCAGAATGTCTTCCAGTATCCAGGAGCAGGAATGGTTCCCCAAGGTGAGGCCAACTTTGCTCCAT CTCTAAGCCCTGGGAGCTCCATGGTGCCGATGCCAATCCCTCCTCCTCAGAGTTCTCTTCTCCAGCAAACTCCACCTGCCTCCGGGTATCAGTCACCAGA CATGAAGGCCTGGCAGCAAGGAGCGATAGGAAACAACAATGTGTTCAGTCAAGCTGTCCAGAACCAGCCCACGCCTGCACAGCCAGGAGTATACAACAAC ATGAGCATCACCGTTTCCATGGCAGGTGGAAATACGAATGTTCAGAACATGAACCCAATGATGGCCCAGATGCAGATGAGCTCTTTGCAGATGCCAGGAA TGAACACTGTGTGCCCTGAGCAGATAAATGATCCCGCACTGAGACACACAGGCCTCTACTGCAACCAGCTCTCATCCACTGACCTTCTCAAAACAGAAGC AGATGGAACCCAGGTGCAACAGGTTCAGGTGTTTGCTGACGTCCAGTGTACAGTGAATCTGGTAGGCGGGGACCCTTACCTGAACCAGCCTGGTCCACTG GGAACTCAAAAGCCCACGTCAGGACCACAGACCCCCCAGGCCCAGCAGAAGAGCCTCCTTCAGCAGCTACTGACTGAATAACCACTTTTAAAGGAATGTG AAATTTAAATAATAGACATACAGAGATATACAAATATATTATATATTTTTCTGAGATTTTTGATATCTCAATCTGCAGCCATTCTTCAGGTCGTAGCATT TGGAGCAAAAAAAAAAAAAAAAAAAAAAAAAGGAGTTTGCTTTTGTCGGGAGATTGAAAGATGTTTTTGTTTCTTTCTTTGTAAAGGCCTTGGATATTGA AAAAATACCAAGGCAGAACAGTTGGACAATCTATTTCTTGAGCCAAATTTAATTATTCTTATTTTTGTAATCAGTCATTGGCTTCTTATCTGGATGAAGG CTTTTGGAGGAGAACCAAAACGACAAGTTCCAAGAAGAAGATGAAGCTCCGCCTCCGCCGCTTAGTCCCAACCCTGCCCAGGAAGAAGGGCCCGTGGGGC TTTGCCTGTGCCCGTCCACCAAAGGCTGTCATGTGTCTCGAAATCAGCAGCCCTCCCCATCCCAATCCCAGGCAGCTTGTGTGTACAATCAGCTTCTCTA GCAACTCTGTATCTGTTGGCTTCAAGAGAATATTTTGCCTCCACATATGTACCCCTTCTCCTTTTTTTAAAGATGGATTTAAACCAAGATGCCTCCAGGA AAGAGGACGAAATGAGTATATTCACAGAGGAATCCAAAAAATACAGTTTGGGGGAAAATGCAATAATTTTTGATGAGATGGGTGAAGGACAAGAAGTGAG TTGTGTCAATTATTGTAGATACAATTTTCTGATTAAATCTGGAAAAATAAAAGGCAGCCTGTTTTTTCTGCTTTTATTGTATTAACAGCTGAGGTAGCTA AAGTTATTTAAAATAAAATTAAATTTATGATCCAAGTAGCTTATTTTTCCCTTTAAATCTCATTGTAAATATATTTGATTTCTTGTAGAAATTGATTTCC TTCTGTTTAATTTTATGCTTTTATTATACTCTTGATTTTTCTAAATTTGTGTGTGAAATATAACATTGATTGAATTGCAGTTACATTTGGTTAGTAATAT TTCATTATTTTAATAACTGTGATGTCATGTATGGATTTACTTTGGGGTTCAAATCAAAATGTCACTGCCAGAAAGAGCTGTTCCAGCTGATCTAGAGCAT ACTGCCCTAGAGTGTCCCTGGGATCATCTGAACAGAAGTGCACAGGCTACTTGTACAGAGAAAAAATTAATACTCAAAGGAAATCTTCATTTTTTAGATT GACTTTGGGAATTTGAATTTTCATCAGTGCAAATATAAATTTCTCTATCCTGCTCTGAGGCTAATTGGTACCATATTTTCCCTTTGTGTCTTGTGACTCT GCCACATCCCATCTCATCCTGGCCTCTGAGTCAAGAACCCAGTGAACTGACTTTCTAGTTCTAGAAGTTCCGCTGCAAGGCCAGGAAAGCTTGAGAAAGG TATTGTGGAAGAAGCAAAGGTAGACCCCCATCACTCACCTTTGTCTGCATCCCTGGGCCTGTGAATGATGACAGCACCTGACATTCTGCACCAGCTACCT CTGCCTCCATGGCAGAGAAAAGGCCATAAGAACAGTGGAAGAGGAGCATGGACTCAGACTTCAAGGAAGAAGCCATTTCCCCAGGTCCTTCCTTCTGCAT CTCACCACCCCTAGTTACAAATAACTCCATTGAACAGCATCTATTCAGAAACTATGCCGAATAAAAAGATTGGTGGAAGGGCTCATGTGGTTAGCAACTA TGAAACAGAAATAGGACACTCAGTTACAAACATTATCTCCTTTAGTTTTTCAGAAAATGCATCCCTGATTTCATTCATTTCCAGCTTGAAAGCCAGCCAT ATTACTCTAGTCCCTACCAAACTGCTCTAGAAGGTCATTTCCATTTTGTTTGTGATATTTAGACGCGCAGACTTCAGGAAGTTCACCTTTAACTTCAGCA TTCCAGATGAAGTTTCCTGACTCAGTGCTTTTGCATAAGGAACTAGAAAAAAAAAGTAAGGAAAATTGGAGATGCTAACATCCTCCCCCATCCCAACTGC ACCTTAAAATATGCATGTCACCTTCAAGGTTTTATAATTGCACTGTTTGTTTTATGTATGTACAGATTAAAATTATTGCTACATTTGAGGAAAATAAAAT TGCTTGCTTCTATGTAATTCCTGTCATTCCACAGGAAATTCACTTTTCCAGCTACTGAATAGAATTTGTTTAACAACCTCATGGGTTGCCTCTTCATTTA CAGGGAAGAAATGAAATGTACATCTGCAGAAATTGCCAAAGCCCAAATTAACGAGTATTATAAAAGGATAATAAAGCATCCCTGAAGCCAAA

refseq_NCOA1.F1 (forward primer)
refseq_NCOA1.R1 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

FQLQLYQRMS*SPQKSLNTTLRGLEINRLFI*L ALNEVRVKRLEPSLENIIIPFPGKLPSGTQDLTI SVLRIHYEQRSLPGVKFFNMSGLGDSSSDPANP DSHKRKGSPCDTLASSTEKRRREQENKYLEELA ELLSANISDIDSLSVKPDKCKILKKTVDQIQLMK RMEQEKSTTDDDVQKSDISSSSQGVIEKESLGP LLLEALDGFFFVVNCEGRIVFVSENVTSYLGYN QEELMNTSVYSILHVGDHAEFVKNLLPKSLVNGV PWPQEATRRNSHTFNCRMLIHPPDEPGTENQEA CQRYEVMQCFTVSQPKSIQEDGEDFQSCLICIA RRLPRPPAITGVESFMTKQDTTGKIISIDTSSLR AAGRTGWEDLVRKCIYAFFQPQGREPSYARQLF QEVMTRGTASSPSYRFILNDGTMLSAHTKCKLC YPQSPDMQPFIMGIHIIDREHSGLSPQDDTNSGM SIPRVNPSVNPSISPAHGVARSSTLPPSNSNMV STRINRQQSSDLHSSSHSNSSNSQGSFGCSPGS QIVANVALNQGQASSQSSNPSLNLNNSPMEGTGI SLAQFMSPRRQVTSGLATRPRMPNNSFPPNIST LSSPVGMTSSACNNNNRSYSNIPVTSLQGMNEG PNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAE SKDNKEIASILNEMIQSDNSSSDGKPLDSGLLH NNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRH ADIDTSCKDVLSCTGTSNSASANSSGGSCPSSHS SLTERHKILHRLLQEGSPSDITTLSVEPDKKDS ASTSVSVTGQVQGNSSIKLELDASKKKESKDHQ LLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQM DPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQF DQLLPTLEKAAQLPGLCETDRMDGAVTSVTIKS EILPASLQSATARPTSRLNRLPELELEAIDNQFG QPGTGDQIPWTNNTVTAINQSKSEDQCISSQLD ELLCPPTTVEGRNDEKALLEQLVSFLSGKDETE LAELDRALGIDKLVQGGGLDVLSERFPPQQATPP LIMEERPNLYSQPYSSPSPTANLPSPFQGMVRQ KPSLGTMPVQVTPPRGAFSPGMGMQPRQTLNRP PAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQFA ATAPVGINMRSGMQQQITPQPPLNAQMLAQRQR ELYSQQHRQRQLIQQQRAMLMRQQSFGNNLPPS SGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPP ASTSPFSQLAANPEASLANRNSMVSRGMTGNIG GQFGTGINPQMQQNVFQYPGAGMVPQGEANFAP SLSPGSSMVPMPIPPPQSSLLQQTPPASGYQSPD MKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNN MSITVSMAGGNTNVQNMNPMMAQMQMSSLQMPG MNTVCPEQINDPALRHTGLYCNQLSSTDLLKTEA DGTQVQQVQVFADVQCTVNLVGGDPYLNQPGPL GTQKPTSGPQTPQAQQKSLLQQLLTE*PLLKEC EI*IIDIQRYTNILYIFLRFLISQSAAILQVVAF GAKKKKKKKKGVCFCREIERCFCFFLCKGLGY* KNTKAEQLDNLFLEPNLIILIFVISHWLLIWMK AFGGEPKRQVPRRR*SSASAA*SQPCPGRRARGA LPVPVHQRLSCVSKSAALPIPIPGSLCVQSASL ATLYLLASREYFASTYVPLLLFLKMDLNQDASR KEDEMSIFTEESKKYSLGENAIIFDEMGEGQEVS CVNYCRYNFLIKSGKIKGSLFFLLLLY*QLR*L KLFKIKLNL*SK*LIFPFKSHCKYI*FLVEIDF LLFNFMLLLYS*FF*ICV*NITLIELQLHLVSNI SLF**L*CHVWIYFGVQIKMSLPERAVPADLEH TALECPWDHLNRSAQATCTEKKLILKGNLHFLD *LWEFEFSSVQI*ISLSCSEANWYHIFPLCLVTL PHPISSWPLSQEPSELTF*F*KFRCKARKA*ER YCGRSKGRPPSLTFVCIPGPVNDDST*HSAPAT SASMAEKRP*EQWKRSMDSDFKEEAISPGPSFCI SPPLVTNNSIEQHLFRNYAE*KDWWKGSCG*QL *NRNRTLSYKHYLL*FFRKCIPDFIHFQLESQP YYSSPYQTALEGHFHFVCDI*TRRLQEVHL*LQH SR*SFLTQCFCIRN*KKKVRKIGDANILPHPNC TLKYACHLQGFIIALFVLCMYRLKLLLHLRKIK LLASM*FLSFHRKFTFPATE*NLFNNLMGCLFIY REEMKCTSAEIAKAQINEYYKRIIKHP*SQ

Frame 1

SSYSYIRE*VNLLRNH*ILL*GA*KLTGCLYNW P*MR*E*RD*SHLWKTSLSHSPGSYPLELKI*P YLF*GFIMNKEVSQV*SFST*VASGTVHPTLLTQ THIRGKDRHVTHWHQARKRGAGSKKINI*KN*L SYCLPTLVTLTA*V*NQTNARF*RKQSIRYS** REWNKRNQQLMTMYRNQTSHQVVKE**KRNPWDL FFWRLWMDFSLL*TVKGELYLCQRM*PAT*VTI RRN**IRASTAYCTWGIMQNL*RICYQNH**ME FLGLKRQHDEIAIPLTAGC*FTLQMSQGPRTKKL ASVMK*CSVSLCHSQNQFKRMEKISSHV*FVLH GDYLGLQLLRV*NPL*PSKILQVKSSLLILVP* ELLAELVGKI**GSAFMLFSNLRAENHLMPDSCS KK**LVALPPAPPIDSY*MMGQCLAPTPSVNFA TLKVQTCNLSSWEFISSTGSTVGFLLKMTLILE CQFPE*IPRSILVSLQLMVWLVHPHCHHPTATWY PPE*TASRAQTFIAAVIVILATAKEVSDAHPEV RL*PMLP*TKDRPVHRAVIPL*TSIILLWKVQE YP*HSSCLQGDRLLLDWQQGPGCQTIPFLLIFRH *ALPLA*QVVPVIIITDLIQTSQ*HLYRV*MKD PITPLASLPVLQSSGR*AHRIHLAD*IYNQQKL SPKITKRLPQF*MK*FNLTTALVMANLWIQGFCI TMTDFQMETVNTLKPVTN*CSF*QQLPNSSYGM LI*TQAAKMSCLAQALPTLPLLTLQEVLVPLLI AH*QNGIKFYTGSYRRVAPQISPLCLSSLIKRTV HLLLCQ*LDRYKETPV*N*NWMLQRKKNQKTIS SYAIF*IKMRKI*DQLQT*AWMM*R*KWKRKNR WIHVIQTQPQ*PNPLLRK*NWRPRASLQLTLTSL ISYCPRWRRQHSCQAYVRQTGWMVRSPV*PSNR RSCQLHFSPPLPDPLPG*IDYLSWNWKQLITNL DNQEQAIRFHGQIIQ*QL*IRVNQKTSVLAHN*M SFSVHPQQ*KGEMMRRLFLNSWYPSLVAKMKLS *LN*TELWELTNLFRGVD*MYYQRDFHHNKQRH L*SWKKDPTFIPSLTLLLLLLPISLALSKAWSGK NLHWGRCLFK*HLPEVLFHLAWACSPGKL*TDL RLHLTSFDFNYSSDYRDNSS*YTKIGKLS*TSL QQLLLLASI*DQACNSKLHLSHP*MLKCWHNVSG NCTVNSTDRGS*YSSKEPCL*GSKALGTTSLPH LDYQFKWGTPVFLRVLHSNSPIHQTMVQIQEPH LLLPARFHN*QQILKHPWPTATAW*AEA*QET*E DSLALESILRCSRMSSSIQEQEWFPKVRPTLLH L*ALGAPWCRCQSLLLRVLFSSKLHLPPGISHQ T*RPGSKER*ETTMCSVKLSRTSPRLHSQEYTTT *ASPFPWQVEIRMFRT*TQ*WPRCR*ALCRCQE *TLCALSR*MIPH*DTQASTATSSHPLTFSKQK QMEPRCNRFRCLLTSSVQ*IW*AGTLT*TSLVHW ELKSPRQDHRPPRPSRRASFSSY*LNNHF*RNV KFK**TYRDIQIYYIFF*DF*YLNLQPFFRS*H LEQKKKKKKKKEFAFVGRLKDVFVSFFVKALDIE KIPRQNSWTIYFLSQI*LFLFL*SVIGFLSG*R LLEENQNDKFQEEDEAPPPPLSPNPAQEEGPVG LCLCPSTKGCHVSRNQQPSPSQSQAACVYNQLL* QLCICWLQENILPPHMYPFSFF*RWI*TKMPPG KRTK*VYSQRNPKNTVWGKMQ*FLMRWVKDKK* VVSIIVDTIF*LNLEK*KAACFFCFYCINS*GS* SYLK*N*IYDPSSLFFPLNLIVNIFDFL*KLIS FCLILCFYYTLDFSKFVCEI*H*LNCSYIWLVI FHYFNNCDVMYGFTLGFKSKCHCQKELFQLI*SI LP*SVPGII*TEVHRLLVQRKN*YSKEIFIF*I DFGNLNFHQCKYKFLYPALRLIGTIFSLCVL*L CHIPSHPGL*VKNPVN*LSSSRSSAARPGKLEKG IVEEAKVDPHHSPLSASLGL*MMTAPDILHQLP LPPWQRKGHKNSGRGAWTQTSRKKPFPQVLPSA SHHP*LQITPLNSIYSETMPNKKIGGRAHVVSNY ETEIGHSVTNIISFSFSENASLISFISSLKASH ITLVPTKLL*KVISILFVIFRRADFRKFTFNFS IPDEVS*LSAFA*GTRKKK*GKLEMLTSSPIPTA P*NMHVTFKVL*LHCLFYVCTD*NYCYI*GK*N CLLLCNSCHSTGNSLFQLLNRICLTTSWVASSF TGKK*NVHLQKLPKPKLTSIIKG**SIPEAK

Frame 2

PVTAISENELISSEITKYYSEGLRN*QVVYIIG LK*GESEETRAISGKHHYPIPREATLWNSRFDH ICFEDSL*TKKSPRCEVFQHEWPRGQFIRPC*P RLT*EERIAM*HTGIKHGKEAQGARK*IFRRTS* VTVCQH**H*QLECKTRQMQDFEENSRSDTANE ENGTREINN**RCTEIRHLIK*SRSDRKGILGT SSFGGFGWIFLCCEL*RENCICVRECNQLLRLQS GGINEYERLQHTARGGSCRICEESATKITSKWS SLASRGNTTK*PYL*LQDANSPSR*ARDREPRS LPAL*SNAVFHCVTAKINSRGWRRFPVMSDLYCT AITSASSYYGCRILYDQARYYR*NHLY*Y*FPE SCWQNWLGRFSEEVHLCFFPTSGQRTILCQTAV PRSDDSWHCLQPLL*IHIE*WDNA*RPHQV*TLL PSKSRHATFHHGNSYHRQGAQWAFSSR*H*FWN VNSPSKSLGQS*YLSSSWCGSFIHIATIQQQHG IHQNKPPAELRPS*QQS**F*QQPRKFRMLTRKS DCSQCCLKPRTGQFTEQ*SLFKPQ*FSYGRYRN IPSTVHVSKETGYFWIGNKAQDAKQFLSS*YFD IKLSRWHDK*CL****PILFKHPSNIFTGYE*RT Q*LRWLLCQFSSPQADELTEFT*QIKYTTSKS* VQR*QRDCLNFK*NDSI*QQL**WQTSGFRASA *Q*QTFRWRQ*ILSNQSQTSAAFDNNCRTAVTAC *YRHKLQRCPVLHRHFQLCLC*LFRRFLSLFS* LIDRTA*NSTPALTGG*PLRYHHFVCRA**KGQ CIYFCVSDWTGTRKLQYKTRTGCFKEKRIKRPSA PTLSFR*R*ERFKINSKPEPG*CKGESGKERTD GSM*YKPNPNDQTHS*GNKTGGPEPVYS*P*PV *SVTAHAGEGSTVARLM*DRQDGWCGHQCNHQIG DPASFTSVRHCQTHFQAK*IT*AGIGSN**PIW TTRNRRSDSMDK*YSDSYKSE*IRRPVY*LTIR *ASLSTHNSRREK**EGSS*TAGILP*WQR*N*A S*TRQSSGN*QTCSGGWIRCIIREISTTTSNAT FDHGRKTQPLFPALLFSFSYCQSP*PFPRHGQA KTFTGDDACSSNTSPRCFFTWHGHAAQANSKQTS GCT*PASTSTTAAITGTTAVDTPKSASYLKPVC SNCSCWHQYEIRHATANYTSATPECSNVGTTSA GTVQSTAPTEAANTAAKSHAYEAAKLWEQPPSLI WTTSSNGEPPSSSGCSTAIPLSTKLWYKSRNPT CFYQPVFTTSSKS*SILGQPQQHGEQRHDRKHR RTVWHWNQSSDAAECLPVSRSRNGSPR*GQLCSI SKPWELHGADANPSSSEFSSPANSTCLRVSVTR HEGLAARSDRKQQCVQSSCPEPAHACTARSIQQ HEHHRFHGRWKYECSEHEPNDGPDADELFADARN EHCVP*ADK*SRTETHRPLLQPALIH*PSQNRS RWNPGATGSGVC*RPVYSESGRRGPLPEPAWST GNSKAHVRTTDPPGPAEEPPSAATD*ITTFKGM* NLNNRHTEIYKYIIYFSEIFDISICSHSSGRSI WSKKKKKKKKRSLLLSGD*KMFLFLSL*RPWIL KKYQGRTVGQSIS*AKFNYSYFCNQSLASYLDEG FWRRTKTTSSKKKMKLRLRRLVPTLPRKKGPWG FACARPPKAVMCLEISSPPHPNPRQLVCTISFS SNSVSVGFKRIFCLHICTPSPFFKDGFKPRCLQE RGRNEYIHRGIQKIQFGGKCNNF**DG*RTRSE LCQLL*IQFSD*IWKNKRQPVFSAFIVLTAEVA KVI*NKIKFMIQVAYFSL*ISL*IYLISCRN*FP SV*FYAFIILLIFLNLCVKYNID*IAVTFG**Y FIILITVMSCMDLLWGSNQNVTARKSCSS*SRA YCPRVSLGSSEQKCTGYLYREKINTQRKSSFFRL TLGI*IFISANINFSILL*G*LVPYFPFVSCDS ATSHLILASESRTQ*TDFLVLEVPLQGQESLRK VLWKKQR*TPITHLCLHPWACE**QHLTFCTSYL CLHGREKAIRTVEEEHGLRLQGRSHFPRSFLLH LTTPSYK*LH*TASIQKLCRIKRLVEGLMWLAT MKQK*DTQLQTLSPLVFQKMHP*FHSFPA*KPAI LL*SLPNCSRRSFPFCL*YLDAQTSGSSPLTSA FQMKFPDSVLLHKELEKKSKENWRC*HPPPSQL HLKICMSPSRFYNCTVCFMYVQIKIIATFEENKI ACFYVIPVIPQEIHFSSY*IEFV*QPHGLPLHL QGRNEMYICRNCQSPN*RVL*KDNKASLKP

Sequence NM_147223

TTCCAGTTACAGCTATATCAGAGAATGAGTTAATCTCCTCAGAAATCACTAAATACTACTCTGAGGGGCTTAGAAATTAACAGGTTGTTTATATAATTGG CCTTAAATGAGGTGAGAGTGAAGAGACTAGAGCCATCTCTGGAAAACATCATTATCCCATTCCCCGGGAAGCTACCCTCTGGAACTCAAGATTTGACCAT ATCTGTTTTGAGGATTCATTATGAACAAAGAAGTCTCCCAGGTGTGAAGTTTTTCAACATGAGTGGCCTCGGGGACAGTTCATCCGACCCTGCTAACCCA GACTCACATAAGAGGAAAGGATCGCCATGTGACACACTGGCATCAAGCACGGAAAAGAGGCGCAGGGAGCAAGAAAATAAATATTTAGAAGAACTAGCTG AGTTACTGTCTGCCAACATTAGTGACATTGACAGCTTGAGTGTAAAACCAGACAAATGCAAGATTTTGAAGAAAACAGTCGATCAGATACAGCTAATGAA GAGAATGGAACAAGAGAAATCAACAACTGATGACGATGTACAGAAATCAGACATCTCATCAAGTAGTCAAGGAGTGATAGAAAAGGAATCCTTGGGACCT CTTCTTTTGGAGGCTTTGGATGGATTTTTCTTTGTTGTGAACTGTGAAGGGAGAATTGTATTTGTGTCAGAGAATGTAACCAGCTACTTAGGTTACAATC AGGAGGAATTAATGAATACGAGCGTCTACAGCATACTGCACGTGGGGGATCATGCAGAATTTGTGAAGAATCTGCTACCAAAATCACTAGTAAATGGAGT TCCTTGGCCTCAAGAGGCAACACGACGAAATAGCCATACCTTTAACTGCAGGATGCTAATTCACCCTCCAGATGAGCCAGGGACCGAGAACCAAGAAGCT TGCCAGCGTTATGAAGTAATGCAGTGTTTCACTGTGTCACAGCCAAAATCAATTCAAGAGGATGGAGAAGATTTCCAGTCATGTCTGATTTGTATTGCAC GGCGATTACCTCGGCCTCCAGCTATTACGGGTGTAGAATCCTTTATGACCAAGCAAGATACTACAGGTAAAATCATCTCTATTGATACTAGTTCCCTGAG AGCTGCTGGCAGAACTGGTTGGGAAGATTTAGTGAGGAAGTGCATTTATGCTTTTTTCCAACCTCAGGGCAGAGAACCATCTTATGCCAGACAGCTGTTC CAAGAAGTGATGACTCGTGGCACTGCCTCCAGCCCCTCCTATAGATTCATATTGAATGATGGGACAATGCTTAGCGCCCACACCAAGTGTAAACTTTGCT ACCCTCAAAGTCCAGACATGCAACCTTTCATCATGGGAATTCATATCATCGACAGGGAGCACAGTGGGCTTTCTCCTCAAGATGACACTAATTCTGGAAT GTCAATTCCCCGAGTAAATCCCTCGGTCAATCCTAGTATCTCTCCAGCTCATGGTGTGGCTCGTTCATCCACATTGCCACCATCCAACAGCAACATGGTA TCCACCAGAATAAACCGCCAGCAGAGCTCAGACCTTCATAGCAGCAGTCATAGTAATTCTAGCAACAGCCAAGGAAGTTTCGGATGCTCACCCGGAAGTC AGATTGTAGCCAATGTTGCCTTAAACCAAGGACAGGCCAGTTCACAGAGCAGTAATCCCTCTTTAAACCTCAATAATTCTCCTATGGAAGGTACAGGAAT ATCCCTAGCACAGTTCATGTCTCCAAGGAGACAGGTTACTTCTGGATTGGCAACAAGGCCCAGGATGCCAAACAATTCCTTTCCTCCTAATATTTCGACA TTAAGCTCTCCCGTTGGCATGACAAGTAGTGCCTGTAATAATAATAACCGATCTTATTCAAACATCCCAGTAACATCTTTACAGGGTATGAATGAAGGAC CCAATAACTCCGTTGGCTTCTCTGCCAGTTCTCCAGTCCTCAGGCAGATGAGCTCACAGAATTCACCTAGCAGATTAAATATACAACCAGCAAAAGCTGA GTCCAAAGATAACAAAGAGATTGCCTCAATTTTAAATGAAATGATTCAATCTGACAACAGCTCTAGTGATGGCAAACCTCTGGATTCAGGGCTTCTGCAT AACAATGACAGACTTTCAGATGGAGACAGTAAATACTCTCAAACCAGTCACAAACTAGTGCAGCTTTTGACAACAACTGCCGAACAGCAGTTACGGCATG CTGATATAGACACAAGCTGCAAAGATGTCCTGTCTTGCACAGGCACTTCCAACTCTGCCTCTGCTAACTCTTCAGGAGGTTCTTGTCCCTCTTCTCATAG CTCATTGACAGAACGGCATAAAATTCTACACCGGCTCTTACAGGAGGGTAGCCCCTCAGATATCACCACTTTGTCTGTCGAGCCTGATAAAAAGGACAGT GCATCTACTTCTGTGTCAGTGACTGGACAGGTACAAGGAAACTCCAGTATAAAACTAGAACTGGATGCTTCAAAGAAAAAAGAATCAAAAGACCATCAGC TCCTACGCTATCTTTTAGATAAAGATGAGAAAGATTTAAGATCAACTCCAAACCTGAGCCTGGATGATGTAAAGGTGAAAGTGGAAAAGAAAGAACAGAT GGATCCATGTAATACAAACCCAACCCCAATGACCAAACCCACTCCTGAGGAAATAAAACTGGAGGCCCAGAGCCAGTTTACAGCTGACCTTGACCAGTTT GATCAGTTACTGCCCACGCTGGAGAAGGCAGCACAGTTGCCAGGCTTATGTGAGACAGACAGGATGGATGGTGCGGTCACCAGTGTAACCATCAAATCGG AGATCCTGCCAGCTTCACTTCAGTCCGCCACTGCCAGACCCACTTCCAGGCTAAATAGATTACCTGAGCTGGAATTGGAAGCAATTGATAACCAATTTGG ACAACCAGGAACAGGCGATCAGATTCCATGGACAAATAATACAGTGACAGCTATAAATCAGAGTAAATCAGAAGACCAGTGTATTAGCTCACAATTAGAT GAGCTTCTCTGTCCACCCACAACAGTAGAAGGGAGAAATGATGAGAAGGCTCTTCTTGAACAGCTGGTATCCTTCCTTAGTGGCAAAGATGAAACTGAGC TAGCTGAACTAGACAGAGCTCTGGGAATTGACAAACTTGTTCAGGGGGGTGGATTAGATGTATTATCAGAGAGATTTCCACCACAACAAGCAACGCCACC TTTGATCATGGAAGAAAGACCCAACCTTTATTCCCAGCCTTACTCTTCTCCTTCTCCTACTGCCAATCTCCCTAGCCCTTTCCAAGGCATGGTCAGGCAA AAACCTTCACTGGGGACGATGCCTGTTCAAGTAACACCTCCCCGAGGTGCTTTTTCACCTGGCATGGGCATGCAGCCCAGGCAAACTCTAAACAGACCTC CGGCTGCACCTAACCAGCTTCGACTTCAACTACAGCAGCGATTACAGGGACAACAGCAGTTGATACACCAAAATCGGCAAGCTATCTTAAACCAGTTTGC AGCAACTGCTCCTGTTGGCATCAATATGAGATCAGGCATGCAACAGCAAATTACACCTCAGCCACCCCTGAATGCTCAAATGTTGGCACAACGTCAGCGG GAACTGTACAGTCAACAGCACCGACAGAGGCAGCTAATACAGCAGCAAAGAGCCATGCTTATGAGGCAGCAAAGCTTTGGGAACAACCTCCCTCCCTCAT CTGGACTACCAGTTCAAATGGGGAACCCCCGTCTTCCTCAGGGTGCTCCACAGCAATTCCCCTATCCACCAAACTATGGTACAAATCCAGGAACCCCACC TGCTTCTACCAGCCCGTTTTCACAACTAGCAGCAAATCCTGAAGCATCCTTGGCCAACCGCAACAGCATGGTGAGCAGAGGCATGACAGGAAACATAGGA GGACAGTTTGGCACTGGAATCAATCCTCAGATGCAGCAGAATGTCTTCCAGTATCCAGGAGCAGGAATGGTTCCCCAAGGTGAGGCCAACTTTGCTCCAT CTCTAAGCCCTGGGAGCTCCATGGTGCCGATGCCAATCCCTCCTCCTCAGAGTTCTCTTCTCCAGCAAACTCCACCTGCCTCCGGGTATCAGTCACCAGA CATGAAGGCCTGGCAGCAAGGAGCGATAGGAAACAACAATGTGTTCAGTCAAGCTGTCCAGAACCAGCCCACGCCTGCACAGCCAGGAGTATACAACAAC ATGAGCATCACCGTTTCCATGGCAGGTGGAAATACGAATGTTCAGAACATGAACCCAATGATGGCCCAGATGCAGATGAGCTCTTTGCAGATGCCAGGAA TGAACACTGTGTGCCCTGAGCAGATAAATGATCCCGCACTGAGACACACAGGCCTCTACTGCAACCAGCTCTCATCCACTGACCTTCTCAAAACAGAAGC AGATGGAACCCAGGACAAGAAGACAGAAGAGTTCTTCTCTGTGGTGACTACAGACTAGAGGAATGCTCTACAGGTGCAACAGGTTCAGGTGTTTGCTGAC GTCCAGTGTACAGTGAATCTGGTAGGCGGGGACCCTTACCTGAACCAGCCTGGTCCACTGGGAACTCAAAAGCCCACGTCAGGACCACAGACCCCCCAGG CCCAGCAGAAGAGCCTCCTTCAGCAGCTACTGACTGAATAACCACTTTTAAAGGAATGTGAAATTTAAATAATAGACATACAGAGATATACAAATATATT ATATATTTTTCTGAGATTTTTGATATCTCAATCTGCAGCCATTCTTCAGGTCGTAGCATTTGGAGCAAAAAAAAAAAAAAAAAAAAAAAAAGGAGTTTGC TTTTGTCGGGAGATTGAAAGATGTTTTTGTTTCTTTCTTTGTAAAGGCCTTGGATATTGAAAAAATACCAAGGCAGAACAGTTGGACAATCTATTTCTTG AGCCAAATTTAATTATTCTTATTTTTGTAATCAGTCATTGGCTTCTTATCTGGATGAAGGCTTTTGGAGGAGAACCAAAACGACAAGTTCCAAGAAGAAG ATGAAGCTCCGCCTCCGCCGCTTAGTCCCAACCCTGCCCAGGAAGAAGGGCCCGTGGGGCTTTGCCTGTGCCCGTCCACCAAAGGCTGTCATGTGTCTCG AAATCAGCAGCCCTCCCCATCCCAATCCCAGGCAGCTTGTGTGTACAATCAGCTTCTCTAGCAACTCTGTATCTGTTGGCTTCAAGAGAATATTTTGCCT CCACATATGTACCCCTTCTCCTTTTTTTAAAGATGGATTTAAACCAAGATGCCTCCAGGAAAGAGGACGAAATGAGTATATTCACAGAGGAATCCAAAAA ATACAGTTTGGGGGAAAATGCAATAATTTTTGATGAGATGGGTGAAGGACAAGAAGTGAGTTGTGTCAATTATTGTAGATACAATTTTCTGATTAAATCT GGAAAAATAAAAGGCAGCCTGTTTTTTCTGCTTTTATTGTATTAACAGCTGAGGTAGCTAAAGTTATTTAAAATAAAATTAAATTTATGATCCAAGTAGC TTATTTTTCCCTTTAAATCTCATTGTAAATATATTTGATTTCTTGTAGAAATTGATTTCCTTCTGTTTAATTTTATGCTTTTATTATACTCTTGATTTTT CTAAATTTGTGTGTGAAATATAACATTGATTGAATTGCAGTTACATTTGGTTAGTAATATTTCATTATTTTAATAACTGTGATGTCATGTATGGATTTAC TTTGGGGTTCAAATCAAAATGTCACTGCCAGAAAGAGCTGTTCCAGCTGATCTAGAGCATACTGCCCTAGAGTGTCCCTGGGATCATCTGAACAGAAGTG CACAGGCTACTTGTACAGAGAAAAAATTAATACTCAAAGGAAATCTTCATTTTTTAGATTGACTTTGGGAATTTGAATTTTCATCAGTGCAAATATAAAT TTCTCTATCCTGCTCTGAGGCTAATTGGTACCATATTTTCCCTTTGTGTCTTGTGACTCTGCCACATCCCATCTCATCCTGGCCTCTGAGTCAAGAACCC AGTGAACTGACTTTCTAGTTCTAGAAGTTCCGCTGCAAGGCCAGGAAAGCTTGAGAAAGGTATTGTGGAAGAAGCAAAGGTAGACCCCCATCACTCACCT TTGTCTGCATCCCTGGGCCTGTGAATGATGACAGCACCTGACATTCTGCACCAGCTACCTCTGCCTCCATGGCAGAGAAAAGGCCATAAGAACAGTGGAA GAGGAGCATGGACTCAGACTTCAAGGAAGAAGCCATTTCCCCAGGTCCTTCCTTCTGCATCTCACCACCCCTAGTTACAAATAACTCCATTGAACAGCAT CTATTCAGAAACTATGCCGAATAAAAAGATTGGTGGAAGGGCTCATGTGGTTAGCAACTATGAAACAGAAATAGGACACTCAGTTACAAACATTATCTCC TTTAGTTTTTCAGAAAATGCATCCCTGATTTCATTCATTTCCAGCTTGAAAGCCAGCCATATTACTCTAGTCCCTACCAAACTGCTCTAGAAGGTCATTT CCATTTTGTTTGTGATATTTAGACGCGCAGACTTCAGGAAGTTCACCTTTAACTTCAGCATTCCAGATGAAGTTTCCTGACTCAGTGCTTTTGCATAAGG AACTAGAAAAAAAAAGTAAGGAAAATTGGAGATGCTAACATCCTCCCCCATCCCAACTGCACCTTAAAATATGCATGTCACCTTCAAGGTTTTATAATTG CACTGTTTGTTTTATGTATGTACAGATTAAAATTATTGCTACATTTGAGGAAAATAAAATTGCTTGCTTCTATGTAATTCCTGTCATTCCACAGGAAATT CACTTTTCCAGCTACTGAATAGAATTTGTTTAACAACCTCATGGGTTGCCTCTTCATTTACAGGGAAGAAATGAAATGTACATCTGCAGAAATTGCCAAA GCCCAAATTAACGAGTATTATAAAAGGATAATAAAGCATCCCTGAAGCCAAA

refseq_NCOA1.F1 (forward primer)
refseq_NCOA1.R1 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

FQLQLYQRMS*SPQKSLNTTLRGLEINRLFI*L ALNEVRVKRLEPSLENIIIPFPGKLPSGTQDLTI SVLRIHYEQRSLPGVKFFNMSGLGDSSSDPANP DSHKRKGSPCDTLASSTEKRRREQENKYLEELA ELLSANISDIDSLSVKPDKCKILKKTVDQIQLMK RMEQEKSTTDDDVQKSDISSSSQGVIEKESLGP LLLEALDGFFFVVNCEGRIVFVSENVTSYLGYN QEELMNTSVYSILHVGDHAEFVKNLLPKSLVNGV PWPQEATRRNSHTFNCRMLIHPPDEPGTENQEA CQRYEVMQCFTVSQPKSIQEDGEDFQSCLICIA RRLPRPPAITGVESFMTKQDTTGKIISIDTSSLR AAGRTGWEDLVRKCIYAFFQPQGREPSYARQLF QEVMTRGTASSPSYRFILNDGTMLSAHTKCKLC YPQSPDMQPFIMGIHIIDREHSGLSPQDDTNSGM SIPRVNPSVNPSISPAHGVARSSTLPPSNSNMV STRINRQQSSDLHSSSHSNSSNSQGSFGCSPGS QIVANVALNQGQASSQSSNPSLNLNNSPMEGTGI SLAQFMSPRRQVTSGLATRPRMPNNSFPPNIST LSSPVGMTSSACNNNNRSYSNIPVTSLQGMNEG PNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAE SKDNKEIASILNEMIQSDNSSSDGKPLDSGLLH NNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRH ADIDTSCKDVLSCTGTSNSASANSSGGSCPSSHS SLTERHKILHRLLQEGSPSDITTLSVEPDKKDS ASTSVSVTGQVQGNSSIKLELDASKKKESKDHQ LLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQM DPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQF DQLLPTLEKAAQLPGLCETDRMDGAVTSVTIKS EILPASLQSATARPTSRLNRLPELELEAIDNQFG QPGTGDQIPWTNNTVTAINQSKSEDQCISSQLD ELLCPPTTVEGRNDEKALLEQLVSFLSGKDETE LAELDRALGIDKLVQGGGLDVLSERFPPQQATPP LIMEERPNLYSQPYSSPSPTANLPSPFQGMVRQ KPSLGTMPVQVTPPRGAFSPGMGMQPRQTLNRP PAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQFA ATAPVGINMRSGMQQQITPQPPLNAQMLAQRQR ELYSQQHRQRQLIQQQRAMLMRQQSFGNNLPPS SGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPP ASTSPFSQLAANPEASLANRNSMVSRGMTGNIG GQFGTGINPQMQQNVFQYPGAGMVPQGEANFAP SLSPGSSMVPMPIPPPQSSLLQQTPPASGYQSPD MKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNN MSITVSMAGGNTNVQNMNPMMAQMQMSSLQMPG MNTVCPEQINDPALRHTGLYCNQLSSTDLLKTEA DGTQDKKTEEFFSVVTTD*RNALQVQQVQVFAD VQCTVNLVGGDPYLNQPGPLGTQKPTSGPQTPQ AQQKSLLQQLLTE*PLLKECEI*IIDIQRYTNIL YIFLRFLISQSAAILQVVAFGAKKKKKKKKGVC FCREIERCFCFFLCKGLGY*KNTKAEQLDNLFL EPNLIILIFVISHWLLIWMKAFGGEPKRQVPRRR *SSASAA*SQPCPGRRARGALPVPVHQRLSCVS KSAALPIPIPGSLCVQSASLATLYLLASREYFA STYVPLLLFLKMDLNQDASRKEDEMSIFTEESKK YSLGENAIIFDEMGEGQEVSCVNYCRYNFLIKS GKIKGSLFFLLLLY*QLR*LKLFKIKLNL*SK* LIFPFKSHCKYI*FLVEIDFLLFNFMLLLYS*FF *ICV*NITLIELQLHLVSNISLF**L*CHVWIY FGVQIKMSLPERAVPADLEHTALECPWDHLNRS AQATCTEKKLILKGNLHFLD*LWEFEFSSVQI*I SLSCSEANWYHIFPLCLVTLPHPISSWPLSQEP SELTF*F*KFRCKARKA*ERYCGRSKGRPPSLT FVCIPGPVNDDST*HSAPATSASMAEKRP*EQWK RSMDSDFKEEAISPGPSFCISPPLVTNNSIEQH LFRNYAE*KDWWKGSCG*QL*NRNRTLSYKHYL L*FFRKCIPDFIHFQLESQPYYSSPYQTALEGHF HFVCDI*TRRLQEVHL*LQHSR*SFLTQCFCIR N*KKKVRKIGDANILPHPNCTLKYACHLQGFII ALFVLCMYRLKLLLHLRKIKLLASM*FLSFHRKF TFPATE*NLFNNLMGCLFIYREEMKCTSAEIAK AQINEYYKRIIKHP*SQ

Frame 1

SSYSYIRE*VNLLRNH*ILL*GA*KLTGCLYNW P*MR*E*RD*SHLWKTSLSHSPGSYPLELKI*P YLF*GFIMNKEVSQV*SFST*VASGTVHPTLLTQ THIRGKDRHVTHWHQARKRGAGSKKINI*KN*L SYCLPTLVTLTA*V*NQTNARF*RKQSIRYS** REWNKRNQQLMTMYRNQTSHQVVKE**KRNPWDL FFWRLWMDFSLL*TVKGELYLCQRM*PAT*VTI RRN**IRASTAYCTWGIMQNL*RICYQNH**ME FLGLKRQHDEIAIPLTAGC*FTLQMSQGPRTKKL ASVMK*CSVSLCHSQNQFKRMEKISSHV*FVLH GDYLGLQLLRV*NPL*PSKILQVKSSLLILVP* ELLAELVGKI**GSAFMLFSNLRAENHLMPDSCS KK**LVALPPAPPIDSY*MMGQCLAPTPSVNFA TLKVQTCNLSSWEFISSTGSTVGFLLKMTLILE CQFPE*IPRSILVSLQLMVWLVHPHCHHPTATWY PPE*TASRAQTFIAAVIVILATAKEVSDAHPEV RL*PMLP*TKDRPVHRAVIPL*TSIILLWKVQE YP*HSSCLQGDRLLLDWQQGPGCQTIPFLLIFRH *ALPLA*QVVPVIIITDLIQTSQ*HLYRV*MKD PITPLASLPVLQSSGR*AHRIHLAD*IYNQQKL SPKITKRLPQF*MK*FNLTTALVMANLWIQGFCI TMTDFQMETVNTLKPVTN*CSF*QQLPNSSYGM LI*TQAAKMSCLAQALPTLPLLTLQEVLVPLLI AH*QNGIKFYTGSYRRVAPQISPLCLSSLIKRTV HLLLCQ*LDRYKETPV*N*NWMLQRKKNQKTIS SYAIF*IKMRKI*DQLQT*AWMM*R*KWKRKNR WIHVIQTQPQ*PNPLLRK*NWRPRASLQLTLTSL ISYCPRWRRQHSCQAYVRQTGWMVRSPV*PSNR RSCQLHFSPPLPDPLPG*IDYLSWNWKQLITNL DNQEQAIRFHGQIIQ*QL*IRVNQKTSVLAHN*M SFSVHPQQ*KGEMMRRLFLNSWYPSLVAKMKLS *LN*TELWELTNLFRGVD*MYYQRDFHHNKQRH L*SWKKDPTFIPSLTLLLLLLPISLALSKAWSGK NLHWGRCLFK*HLPEVLFHLAWACSPGKL*TDL RLHLTSFDFNYSSDYRDNSS*YTKIGKLS*TSL QQLLLLASI*DQACNSKLHLSHP*MLKCWHNVSG NCTVNSTDRGS*YSSKEPCL*GSKALGTTSLPH LDYQFKWGTPVFLRVLHSNSPIHQTMVQIQEPH LLLPARFHN*QQILKHPWPTATAW*AEA*QET*E DSLALESILRCSRMSSSIQEQEWFPKVRPTLLH L*ALGAPWCRCQSLLLRVLFSSKLHLPPGISHQ T*RPGSKER*ETTMCSVKLSRTSPRLHSQEYTTT *ASPFPWQVEIRMFRT*TQ*WPRCR*ALCRCQE *TLCALSR*MIPH*DTQASTATSSHPLTFSKQK QMEPRTRRQKSSSLW*LQTRGMLYRCNRFRCLLT SSVQ*IW*AGTLT*TSLVHWELKSPRQDHRPPR PSRRASFSSY*LNNHF*RNVKFK**TYRDIQIY YIFF*DF*YLNLQPFFRS*HLEQKKKKKKKKEFA FVGRLKDVFVSFFVKALDIEKIPRQNSWTIYFL SQI*LFLFL*SVIGFLSG*RLLEENQNDKFQEE DEAPPPPLSPNPAQEEGPVGLCLCPSTKGCHVSR NQQPSPSQSQAACVYNQLL*QLCICWLQENILP PHMYPFSFF*RWI*TKMPPGKRTK*VYSQRNPK NTVWGKMQ*FLMRWVKDKK*VVSIIVDTIF*LNL EK*KAACFFCFYCINS*GS*SYLK*N*IYDPSS LFFPLNLIVNIFDFL*KLISFCLILCFYYTLDF SKFVCEI*H*LNCSYIWLVIFHYFNNCDVMYGFT LGFKSKCHCQKELFQLI*SILP*SVPGII*TEV HRLLVQRKN*YSKEIFIF*IDFGNLNFHQCKYK FLYPALRLIGTIFSLCVL*LCHIPSHPGL*VKNP VN*LSSSRSSAARPGKLEKGIVEEAKVDPHHSP LSASLGL*MMTAPDILHQLPLPPWQRKGHKNSG RGAWTQTSRKKPFPQVLPSASHHP*LQITPLNSI YSETMPNKKIGGRAHVVSNYETEIGHSVTNIIS FSFSENASLISFISSLKASHITLVPTKLL*KVI SILFVIFRRADFRKFTFNFSIPDEVS*LSAFA*G TRKKK*GKLEMLTSSPIPTAP*NMHVTFKVL*L HCLFYVCTD*NYCYI*GK*NCLLLCNSCHSTGN SLFQLLNRICLTTSWVASSFTGKK*NVHLQKLPK PKLTSIIKG**SIPEAK

Frame 2

PVTAISENELISSEITKYYSEGLRN*QVVYIIG LK*GESEETRAISGKHHYPIPREATLWNSRFDH ICFEDSL*TKKSPRCEVFQHEWPRGQFIRPC*P RLT*EERIAM*HTGIKHGKEAQGARK*IFRRTS* VTVCQH**H*QLECKTRQMQDFEENSRSDTANE ENGTREINN**RCTEIRHLIK*SRSDRKGILGT SSFGGFGWIFLCCEL*RENCICVRECNQLLRLQS GGINEYERLQHTARGGSCRICEESATKITSKWS SLASRGNTTK*PYL*LQDANSPSR*ARDREPRS LPAL*SNAVFHCVTAKINSRGWRRFPVMSDLYCT AITSASSYYGCRILYDQARYYR*NHLY*Y*FPE SCWQNWLGRFSEEVHLCFFPTSGQRTILCQTAV PRSDDSWHCLQPLL*IHIE*WDNA*RPHQV*TLL PSKSRHATFHHGNSYHRQGAQWAFSSR*H*FWN VNSPSKSLGQS*YLSSSWCGSFIHIATIQQQHG IHQNKPPAELRPS*QQS**F*QQPRKFRMLTRKS DCSQCCLKPRTGQFTEQ*SLFKPQ*FSYGRYRN IPSTVHVSKETGYFWIGNKAQDAKQFLSS*YFD IKLSRWHDK*CL****PILFKHPSNIFTGYE*RT Q*LRWLLCQFSSPQADELTEFT*QIKYTTSKS* VQR*QRDCLNFK*NDSI*QQL**WQTSGFRASA *Q*QTFRWRQ*ILSNQSQTSAAFDNNCRTAVTAC *YRHKLQRCPVLHRHFQLCLC*LFRRFLSLFS* LIDRTA*NSTPALTGG*PLRYHHFVCRA**KGQ CIYFCVSDWTGTRKLQYKTRTGCFKEKRIKRPSA PTLSFR*R*ERFKINSKPEPG*CKGESGKERTD GSM*YKPNPNDQTHS*GNKTGGPEPVYS*P*PV *SVTAHAGEGSTVARLM*DRQDGWCGHQCNHQIG DPASFTSVRHCQTHFQAK*IT*AGIGSN**PIW TTRNRRSDSMDK*YSDSYKSE*IRRPVY*LTIR *ASLSTHNSRREK**EGSS*TAGILP*WQR*N*A S*TRQSSGN*QTCSGGWIRCIIREISTTTSNAT FDHGRKTQPLFPALLFSFSYCQSP*PFPRHGQA KTFTGDDACSSNTSPRCFFTWHGHAAQANSKQTS GCT*PASTSTTAAITGTTAVDTPKSASYLKPVC SNCSCWHQYEIRHATANYTSATPECSNVGTTSA GTVQSTAPTEAANTAAKSHAYEAAKLWEQPPSLI WTTSSNGEPPSSSGCSTAIPLSTKLWYKSRNPT CFYQPVFTTSSKS*SILGQPQQHGEQRHDRKHR RTVWHWNQSSDAAECLPVSRSRNGSPR*GQLCSI SKPWELHGADANPSSSEFSSPANSTCLRVSVTR HEGLAARSDRKQQCVQSSCPEPAHACTARSIQQ HEHHRFHGRWKYECSEHEPNDGPDADELFADARN EHCVP*ADK*SRTETHRPLLQPALIH*PSQNRS RWNPGQEDRRVLLCGDYRLEECSTGATGSGVC* RPVYSESGRRGPLPEPAWSTGNSKAHVRTTDPPG PAEEPPSAATD*ITTFKGM*NLNNRHTEIYKYI IYFSEIFDISICSHSSGRSIWSKKKKKKKKRSL LLSGD*KMFLFLSL*RPWILKKYQGRTVGQSIS* AKFNYSYFCNQSLASYLDEGFWRRTKTTSSKKK MKLRLRRLVPTLPRKKGPWGFACARPPKAVMCL EISSPPHPNPRQLVCTISFSSNSVSVGFKRIFCL HICTPSPFFKDGFKPRCLQERGRNEYIHRGIQK IQFGGKCNNF**DG*RTRSELCQLL*IQFSD*I WKNKRQPVFSAFIVLTAEVAKVI*NKIKFMIQVA YFSL*ISL*IYLISCRN*FPSV*FYAFIILLIF LNLCVKYNID*IAVTFG**YFIILITVMSCMDL LWGSNQNVTARKSCSS*SRAYCPRVSLGSSEQKC TGYLYREKINTQRKSSFFRLTLGI*IFISANIN FSILL*G*LVPYFPFVSCDSATSHLILASESRT Q*TDFLVLEVPLQGQESLRKVLWKKQR*TPITHL CLHPWACE**QHLTFCTSYLCLHGREKAIRTVE EEHGLRLQGRSHFPRSFLLHLTTPSYK*LH*TA SIQKLCRIKRLVEGLMWLATMKQK*DTQLQTLSP LVFQKMHP*FHSFPA*KPAILL*SLPNCSRRSF PFCL*YLDAQTSGSSPLTSAFQMKFPDSVLLHK ELEKKSKENWRC*HPPPSQLHLKICMSPSRFYNC TVCFMYVQIKIIATFEENKIACFYVIPVIPQEI HFSSY*IEFV*QPHGLPLHLQGRNEMYICRNCQ SPN*RVL*KDNKASLKP