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Sequence XRCC1.fAug05
GCGGCCGCCGCCTCTCACCCAACGCACTACGACGCCCTCATCCTCGTCACCCCTGGGGCCCCCACTGAGAAGGACTGGGCCCAGGTCCAGGCCTTGCTGCTACCAGATGCGCCTCTTGTCTGCGTGCGCACAGACGGCGAGGGCGAGGATCCGGAGTGTCTGGGAGAAGTTGGAGAAGGAGGAGCAGATACACAGTGTGG
ACATTGGGAATGATGGCTCAGCTTTCGTGGAGGTGCTGGTGGGCAGTTCAGCTGGAGGCGCTGGGGAGCAAGACTATGAGGTCCTTCTGGTCACCTCATC
TTTCATGTCCCCTTCCGAGAGCCGCAGTGGCTCAAACCCCAACCGCGTTCGCATGTTTGGGCCTGACAAGCTGGTCCGGGCAGCCGCCGAGAAGCGCTGG
GACCGGGTCAAAATTGTTTGCAGCCAGCCCTACAGCAAGGACTCCCCCTTTGGCTTGAGTTTTGTACGGTTTCATAGCCCCCCAGACAAAGATGAGGCAG
AGGCCCCGTCCCAGAAGGTGACAGTGACCAAGCTTGGCCAGTTCCGTGTGAAGGAGGAGGATGAGAGCGCCAACTCTCTGAGGCCGGGGGCTCTCTTCTT
CAGCCGGATCAACAAGACATCCCCAGCAAACCACCAGCCCAGCTGTCGCCATCTGTTCCCAAGAGACCTAAATTGCCAGCTCCAACTCGTACCCCAGCCA
CAGCCCCAGTCCCTGCCCGAGCACAGGGGGCAGTGACAGGCAAACCCCGAGGAGAAGGCACCGAGCCCAGACGACCCCGAGCTGGCCCAGAGGAGCTGGG
GAAGATCCTTCAGGGTGTGGTAGTGGTGCTGAGTGGCTTCCAGAACCCCTTCCGCTCCGAGCTGCGAGATAAGGCCCTAGAGCTTGGGGCCAAGTATCGG
CCAGACTGGACCCGGGACAGCACGCACCTCATCTGTGCCTTTGCCAACACCCCCAAGTACAGCCAGGTCCTAGGCCTGGGAGGCCGCATCGTGCGTAAGG
AGTGGGTGCTGGACTGTCACCGCATGCGTCGGCGGCTGCCCTCCCAGAGGTACCTCATGGCAGGGCCAGGTTCCAGCAGTGAGGAGGATGAGGCCTCTCA
CAGCGGTGGCAGCGGAGATGAAGCCCCCAAGCTTCCTCAGAAGCAACCCCAGACCAAAACCAAGCCCACTCAGGCAGCTGGACCCAGCTCACCCCAGAAG
CCCCCAACCCCTGAAGAGACCAAAGCAGCCTCACCAGTGCTCCAGGAAGATATAGACATTGAGGGGGTACAGTCAGAAGGACAGGACAATGGGGCGGAAG
ATTCTGGGGACACAGAGGATGAGCTGAGGAGGGTGGCAGAGCAGAAGGAACACAGACTGCCCCCTGGCCAGGAGGAGAATGGGGAAGACCCGTATGCAGG
CTCCACGGATGAGAACACGGACAGTGAGGAACACCAGGAGCCTCCTGATCTGCCAGTCCCTGAGCTCCCAGATTTCTTCCAGGGCAAGCACTTCTTTCTT
TACGGGGAGTTCCCTGGGGACGAGCGGCGGAAACTCATCCGATACGTCACAGCCTTCAATGGGTGAGTCTCCAGGGAC
- XRCC1.u.f.14 (forward primer)
- XRCC1.u.r.18 (reverse primer)
- Exon skipping and alternative donor or acceptor
Frame 0
AAAASHPTHYDALILVTPGAPTEKDWAQVQALLLPDAPLVCVRTDGEGEDPECLGEVGEGGADTQCG
HWE*WLSFRGGAGGQFSWRRWGARL*GPSGHLI
FHVPFREPQWLKPQPRSHVWA*QAGPGSRREAL
GPGQNCLQPALQQGLPLWLEFCTVS*PPRQR*GR
GPVPEGDSDQAWPVPCEGGG*ERQLSEAGGSLL
QPDQQDIPSKPPAQLSPSVPKRPKLPAPTRTPA
TAPVPARAQGAVTGKPRGEGTEPRRPRAGPEELG
KILQGVVVVLSGFQNPFRSELRDKALELGAKYR
PDWTRDSTHLICAFANTPKYSQVLGLGGRIVRK
EWVLDCHRMRRRLPSQRYLMAGPGSSSEEDEASH
SGGSGDEAPKLPQKQPQTKTKPTQAAGPSSPQK
PPTPEETKAASPVLQEDIDIEGVQSEGQDNGAE
DSGDTEDELRRVAEQKEHRLPPGQEENGEDPYAG
STDENTDSEEHQEPPDLPVPELPDFFQGKHFFL
YGEFPGDERRKLIRYVTAFNG*VSRD
Frame 1
RPPPLTQRTTTPSSSSPLGPPLRRTGPRSRPCCYQMRLLSACAQTARARIRSVWEKLEKEEQIHSV
DIGNDGSAFVEVLVGSSAGGAGEQDYEVLLVTSS
FMSPSESRSGSNPNRVRMFGPDKLVRAAAEKRW
DRVKIVCSQPYSKDSPFGLSFVRFHSPPDKDEA
EAPSQKVTVTKLGQFRVKEEDESANSLRPGALFF
SRINKTSPANHQPSCRHLFPRDLNCQLQLVPQP
QPQSLPEHRGQ*QANPEEKAPSPDDPELAQRSW
GRSFRVW*WC*VASRTPSAPSCEIRP*SLGPSIG
QTGPGTARTSSVPLPTPPSTARS*AWEAASCVR
SGCWTVTACVGGCPPRGTSWQGQVPAVRRMRPL
TAVAAEMKPPSFLRSNPRPKPSPLRQLDPAHPRS
PQPLKRPKQPHQCSRKI*TLRGYSQKDRTMGRK
ILGTQRMS*GGWQSRRNTDCPLARRRMGKTRMQ
APRMRTRTVRNTRSLLICQSLSSQISSRASTSFF
TGSSLGTSGGNSSDTSQPSMGESPG
Frame 2
GRRLSPNALRRPHPRHPWGPH*EGLGPGPGLAATRCASCLRAHRRRGRGSGVSGRSWRRRSRYTVW
TLGMMAQLSWRCWWAVQLEALGSKTMRSFWSPH
LSCPLPRAAVAQTPTAFACLGLTSWSGQPPRSAG
TGSKLFAASPTARTPPLA*VLYGFIAPQTKMRQ
RPRPRR*Q*PSLASSV*RRRMRAPTL*GRGLSS
SAGSTRHPQQTTSPAVAICSQET*IASSNSYPSH
SPSPCPSTGGSDRQTPRRRHRAQTTPSWPRGAG
EDPSGCGSGAEWLPEPLPLRAAR*GPRAWGQVS
ARLDPGQHAPHLCLCQHPQVQPGPRPGRPHRA*G
VGAGLSPHASAAALPEVPHGRARFQQ*GG*GLS
QRWQRR*SPQASSEATPDQNQAHSGSWTQLTPE
APNP*RDQSSLTSAPGRYRH*GGTVRRTGQWGGR
FWGHRG*AEEGGRAEGTQTAPWPGGEWGRPVCR
LHG*EHGQ*GTPGAS*SASP*APRFLPGQALLS
LRGVPWGRAAETHPIRHSLQWVSLQG
Sequence XRCC1.bAug05
TCCCTTGGCCCCAGGAGACAGGGGTTGCAGAAAGCCGAGATCGTGCCACTGCACTCCATCCTGGGTGAGAGAGCAAGACCCTGTCTCAACAAAAAATTTTTAAAAAATAAAATAAATAATAATACAGCAAAAAGATTTGCTTTCTCGGCTTCAGTGTGGGCGGTAACTCCATCGTGCAATGAGAAAGGCGAATTTCTTCC
AGACACCAATCCCGGAGGTCGCTTCTGTTGCTAGGCTCCCAGAAAGCAGGGTTCGGACGTCATTGGGAGGCGAGGCTAGAGCGGGGTTGTGTGTGGCGGA
GGGAGGCGGGGCTGGAGGAAACGCTCGTTGCTAAGGAACGCAGCGCTCTTCCCGCTCTGGAGAGGCGCGACTGGGCTTGCGCAGTGTCGACGCCGGCGCC
GGCGCGCCGGGGTTTGAAAGGCCCGAGCCTCGCGCGCTTGCGCACTTTAGCCAGCGCAGGGCGCACCCCGCCCCCTCCCACTCTCCCTGCCCCTCGGACC
CCATACTCTACCTCATCCTTCTGGCCAGGCGAAGCCCACGACGTTGACATGCCGGAGATCCGCCTCCGCCATGTCGTGTCCTGCAGCAGCCAGGACTCGA
CTCACTGTGCAGAAAATCTTCTCAAGGCAGACACTTACCGAAAATGGCGGGCAGCCAAGGCAGGCGAGAAGACCATCTCTGTGGTCCTACAGTTGGAGAA
GGAGGAGCAGATACACAGTGTGGACATTGGGAATGATGGCTCAGCTTTCGTGGAGGTGCTGGTGGGCAGTTCAGCTGGAGGCGCTGGGGAGCAAGACTAT
GAGGTCCTTCTGGTCACCTCATCTTTCATGTCCCCTTCCGAGAGCCGCAGTGGCTCAAACCCCAACCGCGTTCGCATGTTTGGGCCTGACAAGCTGGTCC
GGGCAGCCGCCGAGAAGCGCTGGGACCGGGTCAAAATTGTTTGCAGCCAGCCCTACAGCAAGGACTCCCCCTTTGGCTTGAGTTTTGTACGGTTTCATAG
CCCCCCAGACAAAGATGAGGCAGAGGCCCCGTCCCAGAAGGTGACAGTGACCAAGCTTGGCCAGTTCCGTGTGAAGGAGGAGGATGAGAGCGCCAACTCT
CTGAGGCCGGGGGCTCTCTTCTTCAGCCGGATCAACAAGACATCCCCAGTCACAGCCAGCGACCCAGCAGGACCTAGCTATGCAGCTGCTACCCTCCAGG
CTTCTAGTGCTGCCTCCTCAGCCTCTCCAGTCTCCAGGGCCATAGGCAGCACCTCCAAGGAGTCTCCCAAAGGGAAGAGGAAGTTGGATTTGAACCAAGA
AGAAAAGAAGACCCCCAGCAAACCACCAGCCCAGCTGTCGCCATCTGTTCCCAAGAGACCTAAATTGCCAGCTCCAACTCGTACCCCAGCCACAGCCCCA
GTCCCTGCCCGAGCACAGGGGGCAGTGACAGGCAAACCCCGAGGAGAAGGCACCGAGCCCAGACGACCCCGAGCTGGCCCAGAGGAGCTGGGGAAGATCC
TTCAGGGTGTGGTAGTGGTGCTGAGTGGCTTCCAGAACCCCTTCCGCTCCGAGCTGCGAGATAAGGCCCTAGAGCTTGGGGCCAAGTATCGGCCAGACTG
GACCCGGGACAGCACGCACCTCATCTGTGCCTTTGCCAACACCCCCAAGTACAGCCAGGTCCTAGGCCTGGGAGGCCGCATCGTGCGTAAGGAGTGGGTG
CTGGACTGTCACCGCATGCGTCGGCGGCTGCCCTCCCAGAGGTACCTCATGGCAGGGCCAGGTTCCAGCAGTGAGGAGGATGAGGCCTCTCACAGCGGTG
GCAGCGGAGATGAAGCCCCCAAGCTTCCTCAGAAGCAACCCCAGACCAAAACCAAGCCCACTCAGGCAGCTGGACCCAGCTCACCCCAGAAGCCCCCAAC
CCCTGAAGAGACCAAAGCAGCCTCACCAGTGCTCCAGGAAGATATAGACATTGAGGGGGTACAGTCAGGACAGGACAATGGGGCGGAAGATTCTGGGGAC
ACAGAGGATGAGCTGAGGAGGGTGGCAGAGCAGAAGGAACACAGACTGCCCCCTGGCCAGGAGGAGAATGGGGAAGACCCGTATGCAGGCTCCACGGATG
AGAACACGGACAGTGAGGAACACCAGGAGCCTCCTGATCTGCCAGTCCCTGAGCTCCCAGATTTCTTCCAGGGCAAGCACTTCTTTCTTTACGGGGAGTT
CCCTGGGGACGAGCGGCGGAAACTCATCCGATACGTCACAGCCTTCAATGGGGAGCTCGAGGACAATATGAGTGACCGGGTTCAGTTTGTGATCACAGCA
CAGGAATGGGATCCCAGCTTTGAGGAGGCCCTGATGGACAACCCCTCCCTGGCATTCGTTCGTCCCCGATGGATCTACAGTTGCAATGAGAAGCAGAAGT
TACTTCCTCACCAGCTCTATGGGGTGGTGCCGCAAGCCTGAAGTATGTGCTATACACACACACACACACACACACACACACACACACACACGATGCATTT
AATAAAGATGAGTTGGTTCTCATCCAAGAGTCTCCCAAAACTCTAAGAGGCTCCCTGGGACCTGGGGAAGAATGCTGGGCACCTCCGTCAGAGATCTGGT
AGAGAAGGAACTCTTTGTCTCTTCTGCTTGGCCCCTTATCCCTGTGTTGGCAAGAGGCAGGGAACTGGGAATCTGACCCTCAGCACTGCCCCTCAACTTT
TTCTGGCCCTCTGAGCCACACCTGTATCTTGGCTGTCCCTTTGTGGCTGGAGGCCTGGGTACCCATGAGGCTTGTCTCTCTCCTGAAGCCTCA
- XRCC1.u.f.14 (forward primer)
- XRCC1.u.r.18 (reverse primer)
- Exon skipping and alternative donor or acceptor
Frame 0
SLGPRRQGLQKAEIVPLHSILGERARPCLNKKFLKNKINNNTAKRFAFSASVWAVTPSCNEKGEFLP
DTNPGGRFCC*APRKQGSDVIGRRG*SGVVCGG
GRRGWRKRSLLRNAALFPLWRGATGLAQCRRRR
RRAGV*KARASRACAL*PAQGAPRPLPLSLPLGP
HTLPHPSGQAKPTTLTCRRSASAMSCPAAARTR
LTVQKIFSRQTLTENGGQPRQARRPSLWSYSWR
RRSRYTVWTLGMMAQLSWRCWWAVQLEALGSKTM
RSFWSPHLSCPLPRAAVAQTPTAFACLGLTSWS
GQPPRSAGTGSKLFAASPTARTPPLA*VLYGFI
APQTKMRQRPRPRR*Q*PSLASSV*RRRMRAPTL
*GRGLSSSAGSTRHPQSQPATQQDLAMQLLPSR
LLVLPPQPLQSPGP*AAPPRSLPKGRGSWI*TK
KKRRPPANHQPSCRHLFPRDLNCQLQLVPQPQPQ
SLPEHRGQ*QANPEEKAPSPDDPELAQRSWGRS
FRVW*WC*VASRTPSAPSCEIRP*SLGPSIGQT
GPGTARTSSVPLPTPPSTARS*AWEAASCVRSGC
WTVTACVGGCPPRGTSWQGQVPAVRRMRPLTAV
AAEMKPPSFLRSNPRPKPSPLRQLDPAHPRSPQ
PLKRPKQPHQCSRKI*TLRGYSQDRTMGRKILGT
QRMS*GGWQSRRNTDCPLARRRMGKTRMQAPRM
RTRTVRNTRSLLICQSLSSQISSRASTSFFTGS
SLGTSGGNSSDTSQPSMGSSRTI*VTGFSL*SQH
RNGIPALRRP*WTTPPWHSFVPDGSTVAMRSRS
YFLTSSMGWCRKPEVCAIHTHTHTHTHTHTRCI
**R*VGSHPRVSQNSKRLPGTWGRMLGTSVRDLV
EKELFVSSAWPLIPVLARGRELGI*PSALPLNF
FWPSEPHLYLGCPFVAGGLGTHEACLSPEAS
Frame 1
PLAPGDRGCRKPRSCHCTPSWVREQDPVSTKNF*KIK*IIIQQKDLLSRLQCGR*LHRAMRKANFF
QTPIPEVASVARLPESRVRTSLGGEARAGLCVAE
GGGAGGNARC*GTQRSSRSGEARLGLRSVDAGA
GAPGFERPEPRALAHFSQRRAHPAPSHSPCPSD
PILYLILLARRSPRR*HAGDPPPPCRVLQQPGLD
SLCRKSSQGRHLPKMAGSQGRREDHLCGPTVGE
GGADTQCGHWE*WLSFRGGAGGQFSWRRWGARL
*GPSGHLIFHVPFREPQWLKPQPRSHVWA*QAGP
GSRREALGPGQNCLQPALQQGLPLWLEFCTVS*
PPRQR*GRGPVPEGDSDQAWPVPCEGGG*ERQL
SEAGGSLLQPDQQDIPSHSQRPSRT*LCSCYPPG
F*CCLLSLSSLQGHRQHLQGVSQREEEVGFEPR
RKEDPQQTTSPAVAICSQET*IASSNSYPSHSP
SPCPSTGGSDRQTPRRRHRAQTTPSWPRGAGEDP
SGCGSGAEWLPEPLPLRAAR*GPRAWGQVSARL
DPGQHAPHLCLCQHPQVQPGPRPGRPHRA*GVG
AGLSPHASAAALPEVPHGRARFQQ*GG*GLSQRW
QRR*SPQASSEATPDQNQAHSGSWTQLTPEAPN
P*RDQSSLTSAPGRYRH*GGTVRTGQWGGRFWG
HRG*AEEGGRAEGTQTAPWPGGEWGRPVCRLHG*
EHGQ*GTPGAS*SASP*APRFLPGQALLSLRGV
PWGRAAETHPIRHSLQWGARGQYE*PGSVCDHS
TGMGSQL*GGPDGQPLPGIRSSPMDLQLQ*EAEV
TSSPALWGGAASLKYVLYTHTHTHTHTHTHDAF
NKDELVLIQESPKTLRGSLGPGEECWAPPSEIW
*RRNSLSLLLGPLSLCWQEAGNWESDPQHCPSTF
SGPLSHTCILAVPLWLEAWVPMRLVSLLKP
Frame 2
PWPQETGVAESRDRATALHPG*ESKTLSQQKIFKK*NK**YSKKICFLGFSVGGNSIVQ*ERRISS
RHQSRRSLLLLGSQKAGFGRHWEARLERGCVWR
REAGLEETLVAKERSALPALERRDWACAVSTPAP
ARRGLKGPSLARLRTLASAGRTPPPPTLPAPRT
PYSTSSFWPGEAHDVDMPEIRLRHVVSCSSQDS
THCAENLLKADTYRKWRAAKAGEKTISVVLQLEK
EEQIHSVDIGNDGSAFVEVLVGSSAGGAGEQDY
EVLLVTSSFMSPSESRSGSNPNRVRMFGPDKLV
RAAAEKRWDRVKIVCSQPYSKDSPFGLSFVRFHS
PPDKDEAEAPSQKVTVTKLGQFRVKEEDESANS
LRPGALFFSRINKTSPVTASDPAGPSYAAATLQ
ASSAASSASPVSRAIGSTSKESPKGKRKLDLNQE
EKKTPSKPPAQLSPSVPKRPKLPAPTRTPATAP
VPARAQGAVTGKPRGEGTEPRRPRAGPEELGKI
LQGVVVVLSGFQNPFRSELRDKALELGAKYRPDW
TRDSTHLICAFANTPKYSQVLGLGGRIVRKEWV
LDCHRMRRRLPSQRYLMAGPGSSSEEDEASHSG
GSGDEAPKLPQKQPQTKTKPTQAAGPSSPQKPPT
PEETKAASPVLQEDIDIEGVQSGQDNGAEDSGD
TEDELRRVAEQKEHRLPPGQEENGEDPYAGSTD
ENTDSEEHQEPPDLPVPELPDFFQGKHFFLYGEF
PGDERRKLIRYVTAFNGELEDNMSDRVQFVITA
QEWDPSFEEALMDNPSLAFVRPRWIYSCNEKQK
LLPHQLYGVVPQA*SMCYTHTHTHTHTHTHTMHL
IKMSWFSSKSLPKL*EAPWDLGKNAGHLRQRSG
REGTLCLFCLAPYPCVGKRQGTGNLTLSTAPQL
FLAL*ATPVSWLSLCGWRPGYP*GLSLS*SL
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