Sequence XRCC1.aAug05
TCCCTTGGCCCCAGGAGACAGGGGTTGCAGAAAGCCGAGATCGTGCCACTGCACTCCATCCTGGGTGAGAGAGCAAGACCCTGTCTCAACAAAAAATTTT
TAAAAAATAAAATAAATAATAATACAGCAAAAAGATTTGCTTTCTCGGCTTCAGTGTGGGCGGTAACTCCATCGTGCAATGAGAAAGGCGAATTTCTTCC
AGACACCAATCCCGGAGGTCGCTTCTGTTGCTAGGCTCCCAGAAAGCAGGGTTCGGACGTCATTGGGAGGCGAGGCTAGAGCGGGGTTGTGTGTGGCGGA
GGGAGGCGGGGCTGGAGGAAACGCTCGTTGCTAAGGAACGCAGCGCTCTTCCCGCTCTGGAGAGGCGCGACTGGGCTTGCGCAGTGTCGACGCCGGCGCC
GGCGCGCCGGGGTTTGAAAGGCCCGAGCCTCGCGCGCTTGCGCACTTTAGCCAGCGCAGGGCGCACCCCGCCCCCTCCCACTCTCCCTGCCCCTCGGACC
CCATACTCTACCTCATCCTTCTGGCCAGGCGAAGCCCACGACGTTGACATGCCGGAGATCCGCCTCCGCCATGTCGTGTCCTGCAGCAGCCAGGACTCGA
CTCACTGTGCAGAAAATCTTCTCAAGGCAGACACTTACCGAAAATGGCGGGCAGCCAAGGCAGGCGAGAAGACCATCTCTGTGGTCCTACAGTTGGAGAA
GGAGGAGCAGATACACAGTGTGGACATTGGGAATGATGGCTCAGCTTTCGTGGAGGTGCTGGTGGGCAGTTCAGCTGGAGGCGCTGGGGAGCAAGACTAT
GAGGTCCTTCTGGTCACCTCATCTTTCATGTCCCCTTCCGAGAGCCGCAGTGGCTCAAACCCCAACCGCGTTCGCATGTTTGGGCCTGACAAGCTGGTCC
GGGCAGCCGCCGAGAAGCGCTGGGACCGGGTCAAAATTGTTTGCAGCCAGCCCTACAGCAAGGACTCCCCCTTTGGCTTGAGTTTTGTACGGTTTCATAG
CCCCCCAGACAAAGATGAGGCAGAGGCCCCGTCCCAGAAGGTGACAGTGACCAAGCTTGGCCAGTTCCGTGTGAAGGAGGAGGATGAGAGCGCCAACTCT
CTGAGGCCGGGGGCTCTCTTCTTCAGCCGGATCAACAAGACATCCCCAGTCACAGCCAGCGACCCAGCAGGACCTAGCTATGCAGCTGCTACCCTCCAGG
CTTCTAGTGCTGCCTCCTCAGCCTCTCCAGTCTCCAGGGCCATAGGCAGCACCTCCAAGCCCCAGGAGTCTCCCAAAGGGAAGAGGAAGTTGGATTTGAA
CCAAGAAGAAAAGAAGACCCCCAGCAAACCACCAGCCCAGCTGTCGCCATCTGTTCCCAAGAGACCTAAATTGCCAGCTCCAACTCGTACCCCAGCCACA
GCCCCAGTCCCTGCCCGAGCACAGGGGGCAGTGACAGGCAAACCCCGAGGAGAAGGCACCGAGCCCAGACGACCCCGAGCTGGCCCAGAGGAGCTGGGGA
AGATCCTTCAGGGTGTGGTAGTGGTGCTGAGTGGCTTCCAGAACCCCTTCCGCTCCGAGCTGCGAGATAAGGCCCTAGAGCTTGGGGCCAAGTATCGGCC
AGACTGGACCCGGGACAGCACGCACCTCATCTGTGCCTTTGCCAACACCCCCAAGTACAGCCAGGTCCTAGGCCTGGGAGGCCGCATCGTGCGTAAGGAG
TGGGTGCTGGACTGTCACCGCATGCGTCGGCGGCTGCCCTCCCAGAGGTACCTCATGGCAGGGCCAGGTTCCAGCAGTGAGGAGGATGAGGCCTCTCACA
GCGGTGGCAGCGGAGATGAAGCCCCCAAGCTTCCTCAGAAGCAACCCCAGACCAAAACCAAGCCCACTCAGGCAGCTGGACCCAGCTCACCCCAGAAGCC
CCCAACCCCTGAAGAGACCAAAGCAGCCTCACCAGTGCTCCAGGAAGATATAGACATTGAGGGGGTACAGTCAGAAGGACAGGACAATGGGGCGGAAGAT
TCTGGGGACACAGAGGATGAGCTGAGGAGGGTGGCAGAGCAGAAGGAACACAGACTGCCCCCTGGCCAGGAGGAGAATGGGGAAGACCCGTATGCAGGCT
CCACGGATGAGAACACGGACAGTGAGGAACACCAGGAGCCTCCTGATCTGCCAGTCCCTGAGCTCCCAGATTTCTTCCAGGGCAAGCACTTCTTTCTTTA
CGGGGAGTTCCCTGGGGACGAGCGGCGGAAACTCATCCGATACGTCACAGCCTTCAATGGGGAGCTCGAGGACAATATGAGTGACCGGGTTCAGTTTGTG
ATCACAGCACAGGAATGGGATCCCAGCTTTGAGGAGGCCCTGATGGACAACCCCTCCCTGGCATTCGTTCGTCCCCGATGGATCTACAGTTGCAATGAGA
AGCAGAAGTTACTTCCTCACCAGCTCTATGGGGTGGTGCCGCAAGCCTGAAGTATGTGCTATACACACACACACACACACACACACACACACACACACAC
GATGCATTTAATAAAGATGAGTTGGTTCTCATCCAAGAGTCTCCCAAAACTCTAAGAGGCTCCCTGGGACCTGGGGAAGAATGCTGGGCACCTCCGTCAG
AGATCTGGTAGAGAAGGAACTCTTTGTCTCTTCTGCTTGGCCCCTTATCCCTGTGTTGGCAAGAGGCAGGGAACTGGGAATCTGACCCTCAGCACTGCCC
CTCAACTTTTTCTGGCCCTCTGAGCCACACCTGTATCTTGGCTGTCCCTTTGTGGCTGGAGGCCTGGGTACCCATGAGGCTTGTCTCTCTCCTGAAGCCT
CA
- XRCC1.u.f.14 (forward primer)
- XRCC1.u.r.18 (reverse primer)
- Intron retention
Frame 0
SLGPRRQGLQKAEIVPLHSILGERARPCLNKKF
LKNKINNNTAKRFAFSASVWAVTPSCNEKGEFLP
DTNPGGRFCC*APRKQGSDVIGRRG*SGVVCGG
GRRGWRKRSLLRNAALFPLWRGATGLAQCRRRR
RRAGV*KARASRACAL*PAQGAPRPLPLSLPLGP
HTLPHPSGQAKPTTLTCRRSASAMSCPAAARTR
LTVQKIFSRQTLTENGGQPRQARRPSLWSYSWR
RRSRYTVWTLGMMAQLSWRCWWAVQLEALGSKTM
RSFWSPHLSCPLPRAAVAQTPTAFACLGLTSWS
GQPPRSAGTGSKLFAASPTARTPPLA*VLYGFI
APQTKMRQRPRPRR*Q*PSLASSV*RRRMRAPTL
*GRGLSSSAGSTRHPQSQPATQQDLAMQLLPSR
LLVLPPQPLQSPGP*AAPPSPRSLPKGRGSWI*
TKKKRRPPANHQPSCRHLFPRDLNCQLQLVPQPQ
PQSLPEHRGQ*QANPEEKAPSPDDPELAQRSWG
RSFRVW*WC*VASRTPSAPSCEIRP*SLGPSIG
QTGPGTARTSSVPLPTPPSTARS*AWEAASCVRS
GCWTVTACVGGCPPRGTSWQGQVPAVRRMRPLT
AVAAEMKPPSFLRSNPRPKPSPLRQLDPAHPRS
PQPLKRPKQPHQCSRKI*TLRGYSQKDRTMGRKI
LGTQRMS*GGWQSRRNTDCPLARRRMGKTRMQA
PRMRTRTVRNTRSLLICQSLSSQISSRASTSFF
TGSSLGTSGGNSSDTSQPSMGSSRTI*VTGFSL*
SQHRNGIPALRRP*WTTPPWHSFVPDGSTVAMR
SRSYFLTSSMGWCRKPEVCAIHTHTHTHTHTHT
RCI**R*VGSHPRVSQNSKRLPGTWGRMLGTSVR
DLVEKELFVSSAWPLIPVLARGRELGI*PSALP
LNFFWPSEPHLYLGCPFVAGGLGTHEACLSPEA
S
Frame 1
PLAPGDRGCRKPRSCHCTPSWVREQDPVSTKNF
*KIK*IIIQQKDLLSRLQCGR*LHRAMRKANFF
QTPIPEVASVARLPESRVRTSLGGEARAGLCVAE
GGGAGGNARC*GTQRSSRSGEARLGLRSVDAGA
GAPGFERPEPRALAHFSQRRAHPAPSHSPCPSD
PILYLILLARRSPRR*HAGDPPPPCRVLQQPGLD
SLCRKSSQGRHLPKMAGSQGRREDHLCGPTVGE
GGADTQCGHWE*WLSFRGGAGGQFSWRRWGARL
*GPSGHLIFHVPFREPQWLKPQPRSHVWA*QAGP
GSRREALGPGQNCLQPALQQGLPLWLEFCTVS*
PPRQR*GRGPVPEGDSDQAWPVPCEGGG*ERQL
SEAGGSLLQPDQQDIPSHSQRPSRT*LCSCYPPG
F*CCLLSLSSLQGHRQHLQAPGVSQREEEVGFE
PRRKEDPQQTTSPAVAICSQET*IASSNSYPSH
SPSPCPSTGGSDRQTPRRRHRAQTTPSWPRGAGE
DPSGCGSGAEWLPEPLPLRAAR*GPRAWGQVSA
RLDPGQHAPHLCLCQHPQVQPGPRPGRPHRA*G
VGAGLSPHASAAALPEVPHGRARFQQ*GG*GLSQ
RWQRR*SPQASSEATPDQNQAHSGSWTQLTPEA
PNP*RDQSSLTSAPGRYRH*GGTVRRTGQWGGR
FWGHRG*AEEGGRAEGTQTAPWPGGEWGRPVCRL
HG*EHGQ*GTPGAS*SASP*APRFLPGQALLSL
RGVPWGRAAETHPIRHSLQWGARGQYE*PGSVC
DHSTGMGSQL*GGPDGQPLPGIRSSPMDLQLQ*E
AEVTSSPALWGGAASLKYVLYTHTHTHTHTHTH
DAFNKDELVLIQESPKTLRGSLGPGEECWAPPS
EIW*RRNSLSLLLGPLSLCWQEAGNWESDPQHCP
STFSGPLSHTCILAVPLWLEAWVPMRLVSLLKP
Frame 2
PWPQETGVAESRDRATALHPG*ESKTLSQQKIF
KK*NK**YSKKICFLGFSVGGNSIVQ*ERRISS
RHQSRRSLLLLGSQKAGFGRHWEARLERGCVWR
REAGLEETLVAKERSALPALERRDWACAVSTPAP
ARRGLKGPSLARLRTLASAGRTPPPPTLPAPRT
PYSTSSFWPGEAHDVDMPEIRLRHVVSCSSQDS
THCAENLLKADTYRKWRAAKAGEKTISVVLQLEK
EEQIHSVDIGNDGSAFVEVLVGSSAGGAGEQDY
EVLLVTSSFMSPSESRSGSNPNRVRMFGPDKLV
RAAAEKRWDRVKIVCSQPYSKDSPFGLSFVRFHS
PPDKDEAEAPSQKVTVTKLGQFRVKEEDESANS
LRPGALFFSRINKTSPVTASDPAGPSYAAATLQ
ASSAASSASPVSRAIGSTSKPQESPKGKRKLDLN
QEEKKTPSKPPAQLSPSVPKRPKLPAPTRTPAT
APVPARAQGAVTGKPRGEGTEPRRPRAGPEELG
KILQGVVVVLSGFQNPFRSELRDKALELGAKYRP
DWTRDSTHLICAFANTPKYSQVLGLGGRIVRKE
WVLDCHRMRRRLPSQRYLMAGPGSSSEEDEASH
SGGSGDEAPKLPQKQPQTKTKPTQAAGPSSPQKP
PTPEETKAASPVLQEDIDIEGVQSEGQDNGAED
SGDTEDELRRVAEQKEHRLPPGQEENGEDPYAG
STDENTDSEEHQEPPDLPVPELPDFFQGKHFFLY
GEFPGDERRKLIRYVTAFNGELEDNMSDRVQFV
ITAQEWDPSFEEALMDNPSLAFVRPRWIYSCNE
KQKLLPHQLYGVVPQA*SMCYTHTHTHTHTHTHT
MHLIKMSWFSSKSLPKL*EAPWDLGKNAGHLRQ
RSGREGTLCLFCLAPYPCVGKRQGTGNLTLSTA
PQLFLAL*ATPVSWLSLCGWRPGYP*GLSLS*SL
Sequence XRCC1.hAug05
TCCCAGCAACAGGCATCCTCCTCTCTCAGATCCTGCCATGGTCACTCCTCAGACCTCCCAACGAGGGTCTCTTGCTGCCCCTCTTGGCTATTTTCAGGTC
TTGTTTAAGACTCACTGTGCAGAAAATCTTCTCAAGGCAGACACTTACCGAAAATGGCGGGCAGCCAAGGCAGGCGAGAAGACCATCTCTGTGGTCCTAC
AGTTGGAGAAGGAGGAGCAGATACACAGTGTGGACATTGGGAATGATGGCTCAGCTTTCGTGGAGGTGCTGGTGGGCAGTTCAGCTGGAGGCGCTGGGGA
GCAAGACTATGAGGTCCTTCTGGTCACCTCATCTTTCATGTCCCCTTCCGAGAGCCGCAGTGGCTCAAACCCCAACCGCGTTCGCATGTTTGGGCCTGAC
AAGCTGGTCCGGGCAGCCGCCGAGAAGCGCTGGGACCGGGTCAAAATTGTTTGCAGCCAGCCCTACAGCAAGGACTCCCCCTTTGGCTTGAGTTTTGTAC
GGTTTCATAGCCCCCCAGACAAAGATGAGGCAGAGGCCCCGTCCCAGAAGGTGACAGTGACCAAGCTTGGCCAGTTCCGTGTGAAGGAGGAGGATGAGAG
CGCCAACTCTCTGAGGCCGGGGGCTCTCTTCTTCAGCCGGATCAACAAGACATCCCCAGTCACAGCCAGCGACCCAGCAGGACCTAGCTATGCAGCTGCT
ACCCTCCAGGCTTCTAGTGCTGCCTCCTCAGCCTCTCCAGTCTCCAGGGCCATAGGCAGCACCTCCAAGCCCCAGGAGTCTCCCAAAGGGAAGAGGAAGT
TGGATTTGAACCAAGAAGAAAAGAAGACCCCCAGCAAACCACCAGCCCAGCTGTCGCCATCTGTTCCCAAGAGACCTAAATTGCCAGCTCCAACTCGTAC
CCCAGCCACAGCC
- XRCC1.u.f.14 (forward primer)
- XRCC1.u.r.18 (reverse primer)
- Intron retention
Frame 0
SQQQASSSLRSCHGHSSDLPTRVSCCPSWLFSG
LV*DSLCRKSSQGRHLPKMAGSQGRREDHLCGPT
VGEGGADTQCGHWE*WLSFRGGAGGQFSWRRWG
ARL*GPSGHLIFHVPFREPQWLKPQPRSHVWA*
QAGPGSRREALGPGQNCLQPALQQGLPLWLEFCT
VS*PPRQR*GRGPVPEGDSDQAWPVPCEGGG*E
RQLSEAGGSLLQPDQQDIPSHSQRPSRT*LCSC
YPPGF*CCLLSLSSLQGHRQHLQAPGVSQREEEV
GFEPRRKEDPQQTTSPAVAICSQET*IASSNSY
PSHS
Frame 1
PSNRHPPLSDPAMVTPQTSQRGSLAAPLGYFQV
LFKTHCAENLLKADTYRKWRAAKAGEKTISVVL
QLEKEEQIHSVDIGNDGSAFVEVLVGSSAGGAGE
QDYEVLLVTSSFMSPSESRSGSNPNRVRMFGPD
KLVRAAAEKRWDRVKIVCSQPYSKDSPFGLSFV
RFHSPPDKDEAEAPSQKVTVTKLGQFRVKEEDES
ANSLRPGALFFSRINKTSPVTASDPAGPSYAAA
TLQASSAASSASPVSRAIGSTSKPQESPKGKRK
LDLNQEEKKTPSKPPAQLSPSVPKRPKLPAPTRT
PATA
Frame 2
PATGILLSQILPWSLLRPPNEGLLLPLLAIFRS
CLRLTVQKIFSRQTLTENGGQPRQARRPSLWSY
SWRRRSRYTVWTLGMMAQLSWRCWWAVQLEALG
SKTMRSFWSPHLSCPLPRAAVAQTPTAFACLGLT
SWSGQPPRSAGTGSKLFAASPTARTPPLA*VLY
GFIAPQTKMRQRPRPRR*Q*PSLASSV*RRRMR
APTL*GRGLSSSAGSTRHPQSQPATQQDLAMQLL
PSRLLVLPPQPLQSPGP*AAPPSPRSLPKGRGS
WI*TKKKRRPPANHQPSCRHLFPRDLNCQLQLV
PQPQ
Sequence XRCC1.cAug05
TCCCTTGGCCCCAGGAGACAGGGGTTGCAGAAAGCCGAGATCGTGCCACTGCACTCCATCCTGGGTGAGAGAGCAAGACCCTGTCTCAACAAAAAATTTT
TAAAAAATAAAATAAATAATAATACAGCAAAAAGATTTGCTTTCTCGGCTTCAGTGTGGGCGGTAACTCCATCGTGCAATGAGAAAGGCGAATTTCTTCC
AGACACCAATCCCGGAGGTCGCTTCTGTTGCTAGGCTCCCAGAAAGCAGGGTTCGGACGTCATTGGGAGGCGAGGCTAGAGCGGGGTTGTGTGTGGCGGA
GGGAGGCGGGGCTGGAGGAAACGCTCGTTGCTAAGGAACGCAGCGCTCTTCCCGCTCTGGAGAGGCGCGACTGGGCTTGCGCAGTGTCGACGCCGGCGCC
GGCGCGCCGGGGTTTGAAAGGCCCGAGCCTCGCGCGCTTGCGCACTTTAGCCAGCGCAGGGCGCACCCCGCCCCCTCCCACTCTCCCTGCCCCTCGGACC
CCATACTCTACCTCATCCTTCTGGCCAGGCGAAGCCCACGACGTTGACATGCCGGAGATCCGCCTCCGCCATGTCGTGTCCTGCAGCAGCCAGGACTCGA
CTCACTGTGCAGAAAATCTTCTCAAGGCAGACACTTACCGAAAATGGCGGGCAGCCAAGGCAGGCGAGAAGACCATCTCTGTGGTCCTACAGGTCCTTCT
GGTCACCTCATCTTTCATGTCCCCTTCCGAGAGCCGCAGTGGCTCAAACCCCAACCGCGTTCGCATGTTTGGGCCTGACAAGCTGGTCCGGGCAGCCGCC
GAGAAGCGCTGGGACCGGGTCAAAATTGTTTGCAGCCAGCCCTACAGCAAGGACTCCCCCTTTGGCTTGAGTTTTGTACGGTTTCATAGCCCCCCAGACA
AAGATGAGGCAGAGGCCCCGTCCCAGAAGGTGACAGTGACCAAGCTTGGCCAGTTCCGTGTGAAGGAGGAGGATGAGAGCGCCAACTCTCTGAGGCCGGG
GGCTCTCTTCTTCAGCCGGATCAACAAGACATCCCCAGTCACAGCCAGCGACCCAGCAGGACCTAGCTATGCAGCTGCTACCCTCCAGGCTTCTAGTGCT
GCCTCCTCAGCCTCTCCAGTCTCCAGGGCCATAGGCAGCACCTCCAAGCCCCAGGAGTCTCCCAAAGGGAAGAGGAAGTTGGATTTGAACCAAGAAGAAA
AGAAGACCCCCAGCAAACCACCAGCCCAGCTGTCGCCATCTGTTCCCAAGAGACCTAAATTGCCAGCTCCAACTCGTACCCCAGCCACAGCCCCAGTCCC
TGCCCGAGCACAGGGGGCAGTGACAGGCAAACCCCGAGGAGAAGGCACCGAGCCCAGACGACCCCGAGCTGGCCCAGAGGAGCTGGGGAAGATCCTTCAG
GGTGTGGTAGTGGTGCTGAGTGGCTTCCAGAACCCCTTCCGCTCCGAGCTGCGAGATAAGGCCCTAGAGCTTGGGGCCAAGTATCGGCCAGACTGGACCC
GGGACAGCACGCACCTCATCTGTGCCTTTGCCAACACCCCCAAGTACAGCCAGGTCCTAGGCCTGGGAGGCCGCATCGTGCGTAAGGAGTGGGTGCTGGA
CTGTCACCGCATGCGTCGGCGGCTGCCCTCCCAGAGGTACCTCATGGCAGGGCCAGGTTCCAGCAGTGAGGAGGATGAGGCCTCTCACAGCGGTGGCAGC
GGAGATGCAACCCCAGACCAAAACCAAGCCCACTCAGGCAGCTGGACCCAGCTCACCCCAGAAGCCCCCAACCCCTGAAGAGACCAAAG
- XRCC1.u.f.14 (forward primer)
- XRCC1.u.r.18 (reverse primer)
- Intron retention
Frame 0
SLGPRRQGLQKAEIVPLHSILGERARPCLNKKF
LKNKINNNTAKRFAFSASVWAVTPSCNEKGEFLP
DTNPGGRFCC*APRKQGSDVIGRRG*SGVVCGG
GRRGWRKRSLLRNAALFPLWRGATGLAQCRRRR
RRAGV*KARASRACAL*PAQGAPRPLPLSLPLGP
HTLPHPSGQAKPTTLTCRRSASAMSCPAAARTR
LTVQKIFSRQTLTENGGQPRQARRPSLWSYRSF
WSPHLSCPLPRAAVAQTPTAFACLGLTSWSGQPP
RSAGTGSKLFAASPTARTPPLA*VLYGFIAPQT
KMRQRPRPRR*Q*PSLASSV*RRRMRAPTL*GR
GLSSSAGSTRHPQSQPATQQDLAMQLLPSRLLVL
PPQPLQSPGP*AAPPSPRSLPKGRGSWI*TKKK
RRPPANHQPSCRHLFPRDLNCQLQLVPQPQPQS
LPEHRGQ*QANPEEKAPSPDDPELAQRSWGRSFR
VW*WC*VASRTPSAPSCEIRP*SLGPSIGQTGP
GTARTSSVPLPTPPSTARS*AWEAASCVRSGCW
TVTACVGGCPPRGTSWQGQVPAVRRMRPLTAVAA
EMQPQTKTKPTQAAGPSSPQKPPTPEETK
Frame 1
PLAPGDRGCRKPRSCHCTPSWVREQDPVSTKNF
*KIK*IIIQQKDLLSRLQCGR*LHRAMRKANFF
QTPIPEVASVARLPESRVRTSLGGEARAGLCVAE
GGGAGGNARC*GTQRSSRSGEARLGLRSVDAGA
GAPGFERPEPRALAHFSQRRAHPAPSHSPCPSD
PILYLILLARRSPRR*HAGDPPPPCRVLQQPGLD
SLCRKSSQGRHLPKMAGSQGRREDHLCGPTGPS
GHLIFHVPFREPQWLKPQPRSHVWA*QAGPGSR
REALGPGQNCLQPALQQGLPLWLEFCTVS*PPRQ
R*GRGPVPEGDSDQAWPVPCEGGG*ERQLSEAG
GSLLQPDQQDIPSHSQRPSRT*LCSCYPPGF*C
CLLSLSSLQGHRQHLQAPGVSQREEEVGFEPRRK
EDPQQTTSPAVAICSQET*IASSNSYPSHSPSP
CPSTGGSDRQTPRRRHRAQTTPSWPRGAGEDPS
GCGSGAEWLPEPLPLRAAR*GPRAWGQVSARLDP
GQHAPHLCLCQHPQVQPGPRPGRPHRA*GVGAG
LSPHASAAALPEVPHGRARFQQ*GG*GLSQRWQ
RRCNPRPKPSPLRQLDPAHPRSPQPLKRPK
Frame 2
PWPQETGVAESRDRATALHPG*ESKTLSQQKIF
KK*NK**YSKKICFLGFSVGGNSIVQ*ERRISS
RHQSRRSLLLLGSQKAGFGRHWEARLERGCVWR
REAGLEETLVAKERSALPALERRDWACAVSTPAP
ARRGLKGPSLARLRTLASAGRTPPPPTLPAPRT
PYSTSSFWPGEAHDVDMPEIRLRHVVSCSSQDS
THCAENLLKADTYRKWRAAKAGEKTISVVLQVLL
VTSSFMSPSESRSGSNPNRVRMFGPDKLVRAAA
EKRWDRVKIVCSQPYSKDSPFGLSFVRFHSPPD
KDEAEAPSQKVTVTKLGQFRVKEEDESANSLRPG
ALFFSRINKTSPVTASDPAGPSYAAATLQASSA
ASSASPVSRAIGSTSKPQESPKGKRKLDLNQEE
KKTPSKPPAQLSPSVPKRPKLPAPTRTPATAPVP
ARAQGAVTGKPRGEGTEPRRPRAGPEELGKILQ
GVVVVLSGFQNPFRSELRDKALELGAKYRPDWT
RDSTHLICAFANTPKYSQVLGLGGRIVRKEWVLD
CHRMRRRLPSQRYLMAGPGSSSEEDEASHSGGS
GDATPDQNQAHSGSWTQLTPEAPNP*RDQ
Sequence XRCC1.gAug05
TCCCTTGGCCCCAGGAGACAGGGGTTGCAGAAAGCCGAGATCGTGCCACTGCACTCCATCCTGGGTGAGAGAGCAAGACCCTGTCTCAACAAAAAATTTT
TAAAAAATAAAATAAATAATAATACAGCAAAAAGATTTGCTTTCTCGGCTTCAGTGTGGGCGGTAACTCCATCGTGCAATGAGAAAGGCGAATTTCTTCC
AGACACCAATCCCGGAGGTCGCTTCTGTTGCTAGGCTCCCAGAAAGCAGGGTTCGGACGTCATTGGGAGGCGAGGCTAGAGCGGGGTTGTGTGTGGCGGA
GGGAGGCGGGGCTGGAGGAAACGCTCGTTGCTAAGGAACGCAGCGCTCTTCCCGCTCTGGAGAGGCGCGACTGGGCTTGCGCAGTGTCGACGCCGGCGCC
GGCGCGCCGGGGTTTGAAAGGCCCGAGCCTCGCGCGCTTGCGCACTTTAGCCAGCGCAGGGCGCACCCCGCCCCCTCCCACTCTCCCTGCCCCTCGGACC
CCATACTCTACCTCATCCTTCTGGCCAGGCGAAGCCCACGACGTTGACATGCCGGAGATCCGCCTCCGCCATGTCGTGTCCTGCAGCAGCCAGGACTCGA
CTCACTGTGCAGAAAATCTTCTCAAGGCAGACACTTACCGAAAATGGCGGGCAGCCAAGGCAGGCGAGAAGACCATCTCTGTGGTCCTACAGTTGGAGAA
GGAGGAGCAGATACACAGTGTGGACATTGGGAATGATGGCTCAGCTTTCGTGGAGGTGCTGGTGGGCAGTTCAGCTGGAGGCGCTGGGGAGCAAGACTAT
GAGGTCCTTCTGGTCACCTCATCTTTCATGTCCCCTTCCGAGAGCCGCAGTGGCTCAAACCCCAACCGCGTTCGCATGTTTGGGCCTGACAAGCTGGTCC
GGGCAGCCGCCGAGAAGCGCTGGGACCGGGTCAAAATTGTTTGCAGCCAGCCCTACAGCAAGGACTCCCCCTTTGGCTTGAGTTTTGTACGGTTTCATAG
CCCCCCAGACAAAGATGAGGCAGAGGCCCCGTCCCAGAAGGTGACAGTGACCAAGCTTGGCCAGTTCCGTGTGAAGGAGGAGGATGAGAGCGCCAACTCT
CTGAGGCCGGGGGCTCTCTTCTTCAGCCGGATCAACAAGACATCCCCAGTCACAGCCAGCGACCCAGCAGGACCTAGCTATGCAGCTGCTACCCTCCAGG
CTTCTAGTGCTGCCTCCTCAGCCTCTCCAGTCTCCAGGGCCATAGGCAGCACCTCCAAGCCCCAGGAGTCTCCCAAAGGGAAGAGGAAGTTGGATTTGAA
CCAAGAAGAAAAGAAGACCCCCAGCAAACCACCAGCCCAGCTGTCGCCATCTGTTCCCAAGAGACCTAAATGTGAGCTAACTAGATCCC
- XRCC1.u.f.14 (forward primer)
- XRCC1.u.r.18 (reverse primer)
- Intron retention
Frame 0
SLGPRRQGLQKAEIVPLHSILGERARPCLNKKF
LKNKINNNTAKRFAFSASVWAVTPSCNEKGEFLP
DTNPGGRFCC*APRKQGSDVIGRRG*SGVVCGG
GRRGWRKRSLLRNAALFPLWRGATGLAQCRRRR
RRAGV*KARASRACAL*PAQGAPRPLPLSLPLGP
HTLPHPSGQAKPTTLTCRRSASAMSCPAAARTR
LTVQKIFSRQTLTENGGQPRQARRPSLWSYSWR
RRSRYTVWTLGMMAQLSWRCWWAVQLEALGSKTM
RSFWSPHLSCPLPRAAVAQTPTAFACLGLTSWS
GQPPRSAGTGSKLFAASPTARTPPLA*VLYGFI
APQTKMRQRPRPRR*Q*PSLASSV*RRRMRAPTL
*GRGLSSSAGSTRHPQSQPATQQDLAMQLLPSR
LLVLPPQPLQSPGP*AAPPSPRSLPKGRGSWI*
TKKKRRPPANHQPSCRHLFPRDLNVS*LDP
Frame 1
PLAPGDRGCRKPRSCHCTPSWVREQDPVSTKNF
*KIK*IIIQQKDLLSRLQCGR*LHRAMRKANFF
QTPIPEVASVARLPESRVRTSLGGEARAGLCVAE
GGGAGGNARC*GTQRSSRSGEARLGLRSVDAGA
GAPGFERPEPRALAHFSQRRAHPAPSHSPCPSD
PILYLILLARRSPRR*HAGDPPPPCRVLQQPGLD
SLCRKSSQGRHLPKMAGSQGRREDHLCGPTVGE
GGADTQCGHWE*WLSFRGGAGGQFSWRRWGARL
*GPSGHLIFHVPFREPQWLKPQPRSHVWA*QAGP
GSRREALGPGQNCLQPALQQGLPLWLEFCTVS*
PPRQR*GRGPVPEGDSDQAWPVPCEGGG*ERQL
SEAGGSLLQPDQQDIPSHSQRPSRT*LCSCYPPG
F*CCLLSLSSLQGHRQHLQAPGVSQREEEVGFE
PRRKEDPQQTTSPAVAICSQET*M*AN*I
Frame 2
PWPQETGVAESRDRATALHPG*ESKTLSQQKIF
KK*NK**YSKKICFLGFSVGGNSIVQ*ERRISS
RHQSRRSLLLLGSQKAGFGRHWEARLERGCVWR
REAGLEETLVAKERSALPALERRDWACAVSTPAP
ARRGLKGPSLARLRTLASAGRTPPPPTLPAPRT
PYSTSSFWPGEAHDVDMPEIRLRHVVSCSSQDS
THCAENLLKADTYRKWRAAKAGEKTISVVLQLEK
EEQIHSVDIGNDGSAFVEVLVGSSAGGAGEQDY
EVLLVTSSFMSPSESRSGSNPNRVRMFGPDKLV
RAAAEKRWDRVKIVCSQPYSKDSPFGLSFVRFHS
PPDKDEAEAPSQKVTVTKLGQFRVKEEDESANS
LRPGALFFSRINKTSPVTASDPAGPSYAAATLQ
ASSAASSASPVSRAIGSTSKPQESPKGKRKLDLN
QEEKKTPSKPPAQLSPSVPKRPKCELTRS
Sequence XRCC1.eAug05
GGCCTCCCAAAATGTTGGGATTACAGGCATGAGCCACTGCACCTGACCTCAGTCTTTTAAACTGTGATAGATACAGATTGCTGACAGTTTTAGTCTTGAG
ATCTAGATTCAAGCCCCCAGCTCTTCCTCTTAATCGGTGACCTCAAGAAAATTGTTTCATTTCTCTAACCTGTTTTCTCATGTGTCCATTGGGAATAATG
ACATCCAAGCCCGGAGTTGTGAAAATTCGGTGACATAATGTCTGCACAAGTGCTCTGTCAACATGTAGGTGTTTGTGTAGAGGGAGGGATTTGTGTTTTT
ATTACTTAGTGGGTGATGATTCCACTGGGCTCTCTTATGATCAAGTGACTCCAGGGAAATCACATTTCATTCTGTTACCCCAGTTGCTGTGGAAACAGAG
TGACTGGAGGCAGAAGAGACAGAACCTGTCTCTGGCCTGGGAGAGACTGAGGGAGTATTGCAGCGGTCACCAACATGTTGGAGAAGGAGGAGCAGATACA
CAGTGTGGACATTGGGAATGATGGCTCAGCTTTCGTGGAGGTGCTGGTGGGCAGTTCAGCTGGAGGCGCTGGGGAGCAAGACTATGAGGTCCTTCTGGTC
ACCTCATCTTTCATGTCCCCTTCCGAGAGCCGCAGTGGCTCAAACCCCAACCGCGTTCGCATGTTTGGGCCTGACAAGCTGGTCCGGGCAGCCGCCGAGA
AGCGCTGGGACCGGGTCAAAATTGTTTGCAGCCAGCCCTACAGCAAGGACTCCCCCTTTGGCTTGAGTTTTGTACGGTTTCATAGCCCCCCAGACAAAGA
TGAGGCAGAGGCCCCGTCCCAGAAGGTGACAGTGACCAAGCTTGGCCAGTTCCGTGTGAAGGAGGAGGATGAGAGCGCCAACTCTCTGAGGCCGGGGGCT
CTCTTCTTCAGCCGGATCAACAAGACATCCCCAGTCACAGCCAGCGACCCAGCAGGACCTAGCTATGCAGCTGCTACCCTCCAGGCTTCTAGTGCTGCCT
CCTCAGCCTCTCCAGTCTCCAGGGCCATAGGCAGCACCTCCAAGCCCCAGGAGTCTCCCAAAGGGAAGAGGAAGTTGGATTTGAACCAAGAAGAAAAGAA
GACCCCCAGCAAACCACCAGCCCAGCTGTCGCCATCTGTTCCCAAGAGACCTAAATCACAGAGGATGAGCTGAGGAGGGTGGCAGAGCAGAAGGAACACA
GACTGCCCCCTGGCCAGGAGGAGAATGGGGAAGACCCGTATGCAGGCTCCACGGATGAGAACACGGACAGTGAGGAACACCAGGAGCCTCCTGATCTGCC
AGTCCCTGAGCTCCCAGATTTCTTCCAGGGCAAGCACTTCTTTCTTTACGGGGAGTTCCCTGGGGACGAGCGGCGGAAACTCATCCGATACGTCACAGCC
TTCAATGGGGAGCTCGAGGACAATATGAGTGACCGGGTTCAGTTTGTGATCACAGCACAGGAATGGGATCCCAGCTTTGAGGAGGCCCTGATGGACAACC
CCTCCCTGGCATTCGTTCGTCCCCGATGGATCTACAGTTGCAATGAGAAGCAGAAGTTACTTCCTCACCAGCTCTATGGGGTGGTGCCGCAAGCCTGAAG
TATGTGCTATACACACACACACACACACACACACACACACACACACACGATGCATTTAATAAAGATGAGTTGGTTCTCATCCAAGAGTCTCCCAAAACTC
TAAGAGGCTCCCTGGGACCTGGGGAAGAATGCTGGGCACCTCCGTCAGAGATCTGGTAGAGAAGGAACTCTTTGTCTCTTCTGCTTGGCCCCTTATCCCT
GTGTTGGCAAGAGGCAGGGAACTGGGAATCTGACCCTCAGCACTGCCCCTCAACTTTTTCTGGCCCTCTGAGCCACACCTGTATCTTGGCTGTCCCTTTG
TGGCTGGAGGCCTGGGTACCCATGAGGCTTGTCTCTCTCCTGAAGCCTCA
- XRCC1.u.f.14 (forward primer)
- XRCC1.u.r.18 (reverse primer)
- Intron retention
Frame 0
GLPKCWDYRHEPLHLTSVF*TVIDTDC*QF*S*
DLDSSPQLFLLIGDLKKIVSFL*PVFSCVHWE**
HPSPEL*KFGDIMSAQVLCQHVGVCVEGGICVF
IT*WVMIPLGSLMIK*LQGNHISFCYPSCCGNR
VTGGRRDRTCLWPGRD*GSIAAVTNMLEKEEQIH
SVDIGNDGSAFVEVLVGSSAGGAGEQDYEVLLV
TSSFMSPSESRSGSNPNRVRMFGPDKLVRAAAE
KRWDRVKIVCSQPYSKDSPFGLSFVRFHSPPDKD
EAEAPSQKVTVTKLGQFRVKEEDESANSLRPGA
LFFSRINKTSPVTASDPAGPSYAAATLQASSAA
SSASPVSRAIGSTSKPQESPKGKRKLDLNQEEKK
TPSKPPAQLSPSVPKRPKSQRMS*GGWQSRRNT
DCPLARRRMGKTRMQAPRMRTRTVRNTRSLLIC
QSLSSQISSRASTSFFTGSSLGTSGGNSSDTSQP
SMGSSRTI*VTGFSL*SQHRNGIPALRRP*WTT
PPWHSFVPDGSTVAMRSRSYFLTSSMGWCRKPE
VCAIHTHTHTHTHTHTRCI**R*VGSHPRVSQNS
KRLPGTWGRMLGTSVRDLVEKELFVSSAWPLIP
VLARGRELGI*PSALPLNFFWPSEPHLYLGCPF
VAGGLGTHEACLSPEAS
Frame 1
ASQNVGITGMSHCT*PQSFKL**IQIADSFSLE
I*IQAPSSSS*SVTSRKLFHFSNLFSHVSIGNN
DIQARSCENSVT*CLHKCSVNM*VFV*REGFVFL
LLSG**FHWALL*SSDSREITFHSVTPVAVETE
*LEAEETEPVSGLGETEGVLQRSPTCWRRRSRY
TVWTLGMMAQLSWRCWWAVQLEALGSKTMRSFWS
PHLSCPLPRAAVAQTPTAFACLGLTSWSGQPPR
SAGTGSKLFAASPTARTPPLA*VLYGFIAPQTK
MRQRPRPRR*Q*PSLASSV*RRRMRAPTL*GRGL
SSSAGSTRHPQSQPATQQDLAMQLLPSRLLVLP
PQPLQSPGP*AAPPSPRSLPKGRGSWI*TKKKR
RPPANHQPSCRHLFPRDLNHRG*AEEGGRAEGTQ
TAPWPGGEWGRPVCRLHG*EHGQ*GTPGAS*SA
SP*APRFLPGQALLSLRGVPWGRAAETHPIRHS
LQWGARGQYE*PGSVCDHSTGMGSQL*GGPDGQP
LPGIRSSPMDLQLQ*EAEVTSSPALWGGAASLK
YVLYTHTHTHTHTHTHDAFNKDELVLIQESPKT
LRGSLGPGEECWAPPSEIW*RRNSLSLLLGPLSL
CWQEAGNWESDPQHCPSTFSGPLSHTCILAVPL
WLEAWVPMRLVSLLKP
Frame 2
PPKMLGLQA*ATAPDLSLLNCDRYRLLTVLVLR
SRFKPPALPLNR*PQENCFISLTCFLMCPLGIM
TSKPGVVKIR*HNVCTSALSTCRCLCRGRDLCF
YYLVGDDSTGLSYDQVTPGKSHFILLPQLLWKQS
DWRQKRQNLSLAWERLREYCSGHQHVGEGGADT
QCGHWE*WLSFRGGAGGQFSWRRWGARL*GPSG
HLIFHVPFREPQWLKPQPRSHVWA*QAGPGSRRE
ALGPGQNCLQPALQQGLPLWLEFCTVS*PPRQR
*GRGPVPEGDSDQAWPVPCEGGG*ERQLSEAGG
SLLQPDQQDIPSHSQRPSRT*LCSCYPPGF*CCL
LSLSSLQGHRQHLQAPGVSQREEEVGFEPRRKE
DPQQTTSPAVAICSQET*ITEDELRRVAEQKEH
RLPPGQEENGEDPYAGSTDENTDSEEHQEPPDLP
VPELPDFFQGKHFFLYGEFPGDERRKLIRYVTA
FNGELEDNMSDRVQFVITAQEWDPSFEEALMDN
PSLAFVRPRWIYSCNEKQKLLPHQLYGVVPQA*S
MCYTHTHTHTHTHTHTMHLIKMSWFSSKSLPKL
*EAPWDLGKNAGHLRQRSGREGTLCLFCLAPYP
CVGKRQGTGNLTLSTAPQLFLAL*ATPVSWLSLC
GWRPGYP*GLSLS*SL
Sequence XRCC1.dAug05
TCCCTTGGCCCCAGGAGACAGGGGTTGCAGAAAGCCGAGATCGTGCCACTGCACTCCATCCTGGGTGAGAGAGCAAGACCCTGTCTCAACAAAAAATTTT
TAAAAAATAAAATAAATAATAATACAGCAAAAAGATTTGCTTTCTCGGCTTCAGTGTGGGCGGTAACTCCATCGTGCAATGAGAAAGGCGAATTTCTTCC
AGACACCAATCCCGGAGGTCGCTTCTGTTGCTAGGCTCCCAGAAAGCAGGGTTCGGACGTCATTGGGAGGCGAGGCTAGAGCGGGGTTGTGTGTGGCGGA
GGGAGGCGGGGCTGGAGGAAACGCTCGTTGCTAAGGAACGCAGCGCTCTTCCCGCTCTGGAGAGGCGCGACTGGGCTTGCGCAGTGTCGACGCCGGCGCC
GGCGCGCCGGGGTTTGAAAGGCCCGAGCCTCGCGCGCTTGCGCACTTTAGCCAGCGCAGGGCGCACCCCGCCCCCTCCCACTCTCCCTGCCCCTCGGACC
CCATACTCTACCTCATCCTTCTGGCCAGGCGAAGCCCACGACGTTGACATGCCGGAGATCCGCCTCCGCCATGTCGTGTCCTGCAGCAGCCAGGACTCGA
CTCACTGTGCAGAAAATCTTCTCAAGGCAGACACTTACCGAAAATGGCGGGCAGCCAAGGCAGGCGAGAAGACCATCTCTGTGGTCCTACAGTTGGAGAA
GGAGGAGCAGATACACAGTGTGGACATTGGGAATGATGGCTCAGCTTTCGTGGAGGTGCTGGTGGGCAGTTCAGCTGGAGGCGCTGGGGAGCAAGACTAT
GAGGTCCTTCTGGTCACCTCATCTTTCATGTCCCCTTCCGAGAGCCGCAGTGGCTCAAACCCCAACCGCGTTCGCATGTTTGGGCCTGACAAGCTGGTCC
GGGCAGCCGCCGAGAAGCGCTGGGACCGGGTCAAAATTGTTTGCAGCCAGCCCTACAGCAAGGACTCCCCCTTTGGCTTGAGTTTTGTACGGTTTCATAG
CCCCCCAGACAAAGATGAGGCAGAGGCCCCGTCCCAGAAGGTGACAGTGACCAAGCTTGGCCAGTTCCGTGTGAAGGAGGAGGATGAGAGCGCCAACTCT
CTGAGGCCGGGGGCTCTCTTCTTCAGCCGGATCAACAAGACATCCCCAGTCACAGCCAGCGACCCAGCAGGACCTAGCTATGCAGCTGCTACCCTCCAGG
CTTCTAGTGCTGCCTCCTCAGCCTCTCCAGTCTCCAGGGCCATAGGCAGCACCTCCAAGGTGAAATCATCAGACTTTGGTGGGGTGGAGGAGGAGAGAAG
CTGGAGGCCTCAATCCATCCCCATCCCCTCAGCCCCAGGAGTCTCCCAAAGGGAAGAGGAAGTTGGATTTGAACCAAGAAGAAAAGAAGACCCCCAGCAA
ACCACCAGCCCAGCTGTCGCCATCTGTTCCCAAGAGACCTAAATTGCCAGCTCCAACTCGTACCCCAGCCACAGCCCCAGTCCCTGCCCGAGCACAGGGG
GCAGTGACAGGCAAACCCCGAGGAGAAGGCACCGAGCCCAGACGACCCCGAGCTGGCCCAGAGGAGCTGGGGAAGATCCTTCAGGGTGTGGTAGTGGTGC
TGAGTGGCTTCCAGAACCCCTTCCGCTCCGAGCTGCGAGATAAGGCCCTAGAGCTTGGGGCCAAGTATCGGCCAGACTGGACCCGGGACAGCACGCACCT
CATCTGTGCCTTTGCCAACACCCCCAAGTACAGCCAGGTCCTAGGCCTGGGAGGCCGCATCGTGCGTAAGGAGTGGGTGCTGGACTGTCACCGCATGCGT
CGGCGGCTGCCCTCCCAGAGGTACCTCATGGCAGGGCCAGGTTCCAGCAGTGAGGAGGATGAGGCCTCTCACAGCGGTGGCAGCGGAGATGAAGCCCCCA
AGCTTCCTCAGAAGCAACCCCAGACCAAAACCAAGCCCACTCAGGCAGCTGGACCCAGCTCACCCCAGAAGCCCCCAACCCCTGAAGAGACCAAAGCAGC
CTCACCAGTGCTCCAGGAAGATATAGACATTGAGGGGGTACAGTCAGAAGGACAGGACAATGGGGCGGAAGATTCTGGGGACACAGAGGATGAGCTGAGG
AGGGTGGCAGAGCAGAAGGAACACAGACTGCCCCCTGGCCAGGAGGAGAATGGGGAAGACCCGTATGCAGGCTCCACGGATGAGAACACGGACAGTGAGG
AACACCAGGAGCCTCCTGATCTGCCAGTCCCTGAGCTCCCAGATTTCTTCCAGGGCAAGCACTTCTTTCTTTACGGGGAGTTCCCTGGGGACGAGCGGCG
GAAACTCATCCGATACGTCACAGCCTTCAATGGGGAGCTCGAGGACAATATGAGTGACCGGGTTCAGTTTGTGATCACAGCACAGGAATGGGATCCCAGC
TTTGAGGAGGCCCTGATGGACAACCCCTCCCTGGCATTCGTTCGTCCCCGATGGATCTACAGTTGCAATGAGAAGCAGAAGTTACTTCCTCACCAGCTCT
ATGGGGTGGTGCCGCAAGCCTGAAGTATGTGCTATACACACACACACACACACACACACACACACACACACACGATGCATTTAATAAAGATGAGTTGGTT
CTCATCCAAGAGTCTCCCAAAACTCTAAGAGGCTCCCTGGGACCTGGGGAAGAATGCTGGGCACCTCCGTCAGAGATCTGGTAGAGAAGGAACTCTTTGT
CTCTTCTGCTTGGCCCCTTATCCCTGTGTTGGCAAGAGGCAGGGAACTGGGAATCTGACCCTCAGCACTGCCCCTCAACTTTTTCTGGCCCTCTGAGCCA
CACCTGTATCTTGGCTGTCCCTTTGTGGCTGGAGGCCTGGGTACCCATGAGGCTTGTCTCTCTCCTGAAGCCTCA
- XRCC1.u.f.14 (forward primer)
- XRCC1.u.r.18 (reverse primer)
- Intron retention
Frame 0
SLGPRRQGLQKAEIVPLHSILGERARPCLNKKF
LKNKINNNTAKRFAFSASVWAVTPSCNEKGEFLP
DTNPGGRFCC*APRKQGSDVIGRRG*SGVVCGG
GRRGWRKRSLLRNAALFPLWRGATGLAQCRRRR
RRAGV*KARASRACAL*PAQGAPRPLPLSLPLGP
HTLPHPSGQAKPTTLTCRRSASAMSCPAAARTR
LTVQKIFSRQTLTENGGQPRQARRPSLWSYSWR
RRSRYTVWTLGMMAQLSWRCWWAVQLEALGSKTM
RSFWSPHLSCPLPRAAVAQTPTAFACLGLTSWS
GQPPRSAGTGSKLFAASPTARTPPLA*VLYGFI
APQTKMRQRPRPRR*Q*PSLASSV*RRRMRAPTL
*GRGLSSSAGSTRHPQSQPATQQDLAMQLLPSR
LLVLPPQPLQSPGP*AAPPR*NHQTLVGWRRRE
AGGLNPSPSPQPQESPKGKRKLDLNQEEKKTPSK
PPAQLSPSVPKRPKLPAPTRTPATAPVPARAQG
AVTGKPRGEGTEPRRPRAGPEELGKILQGVVVV
LSGFQNPFRSELRDKALELGAKYRPDWTRDSTHL
ICAFANTPKYSQVLGLGGRIVRKEWVLDCHRMR
RRLPSQRYLMAGPGSSSEEDEASHSGGSGDEAP
KLPQKQPQTKTKPTQAAGPSSPQKPPTPEETKAA
SPVLQEDIDIEGVQSEGQDNGAEDSGDTEDELR
RVAEQKEHRLPPGQEENGEDPYAGSTDENTDSE
EHQEPPDLPVPELPDFFQGKHFFLYGEFPGDERR
KLIRYVTAFNGELEDNMSDRVQFVITAQEWDPS
FEEALMDNPSLAFVRPRWIYSCNEKQKLLPHQL
YGVVPQA*SMCYTHTHTHTHTHTHTMHLIKMSWF
SSKSLPKL*EAPWDLGKNAGHLRQRSGREGTLC
LFCLAPYPCVGKRQGTGNLTLSTAPQLFLAL*A
TPVSWLSLCGWRPGYP*GLSLS*SL
Frame 1
PLAPGDRGCRKPRSCHCTPSWVREQDPVSTKNF
*KIK*IIIQQKDLLSRLQCGR*LHRAMRKANFF
QTPIPEVASVARLPESRVRTSLGGEARAGLCVAE
GGGAGGNARC*GTQRSSRSGEARLGLRSVDAGA
GAPGFERPEPRALAHFSQRRAHPAPSHSPCPSD
PILYLILLARRSPRR*HAGDPPPPCRVLQQPGLD
SLCRKSSQGRHLPKMAGSQGRREDHLCGPTVGE
GGADTQCGHWE*WLSFRGGAGGQFSWRRWGARL
*GPSGHLIFHVPFREPQWLKPQPRSHVWA*QAGP
GSRREALGPGQNCLQPALQQGLPLWLEFCTVS*
PPRQR*GRGPVPEGDSDQAWPVPCEGGG*ERQL
SEAGGSLLQPDQQDIPSHSQRPSRT*LCSCYPPG
F*CCLLSLSSLQGHRQHLQGEIIRLWWGGGGEK
LEASIHPHPLSPRSLPKGRGSWI*TKKKRRPPA
NHQPSCRHLFPRDLNCQLQLVPQPQPQSLPEHRG
Q*QANPEEKAPSPDDPELAQRSWGRSFRVW*WC
*VASRTPSAPSCEIRP*SLGPSIGQTGPGTART
SSVPLPTPPSTARS*AWEAASCVRSGCWTVTACV
GGCPPRGTSWQGQVPAVRRMRPLTAVAAEMKPP
SFLRSNPRPKPSPLRQLDPAHPRSPQPLKRPKQ
PHQCSRKI*TLRGYSQKDRTMGRKILGTQRMS*G
GWQSRRNTDCPLARRRMGKTRMQAPRMRTRTVR
NTRSLLICQSLSSQISSRASTSFFTGSSLGTSG
GNSSDTSQPSMGSSRTI*VTGFSL*SQHRNGIPA
LRRP*WTTPPWHSFVPDGSTVAMRSRSYFLTSS
MGWCRKPEVCAIHTHTHTHTHTHTRCI**R*VG
SHPRVSQNSKRLPGTWGRMLGTSVRDLVEKELFV
SSAWPLIPVLARGRELGI*PSALPLNFFWPSEP
HLYLGCPFVAGGLGTHEACLSPEAS
Frame 2
PWPQETGVAESRDRATALHPG*ESKTLSQQKIF
KK*NK**YSKKICFLGFSVGGNSIVQ*ERRISS
RHQSRRSLLLLGSQKAGFGRHWEARLERGCVWR
REAGLEETLVAKERSALPALERRDWACAVSTPAP
ARRGLKGPSLARLRTLASAGRTPPPPTLPAPRT
PYSTSSFWPGEAHDVDMPEIRLRHVVSCSSQDS
THCAENLLKADTYRKWRAAKAGEKTISVVLQLEK
EEQIHSVDIGNDGSAFVEVLVGSSAGGAGEQDY
EVLLVTSSFMSPSESRSGSNPNRVRMFGPDKLV
RAAAEKRWDRVKIVCSQPYSKDSPFGLSFVRFHS
PPDKDEAEAPSQKVTVTKLGQFRVKEEDESANS
LRPGALFFSRINKTSPVTASDPAGPSYAAATLQ
ASSAASSASPVSRAIGSTSKVKSSDFGGVEEERS
WRPQSIPIPSAPGVSQREEEVGFEPRRKEDPQQ
TTSPAVAICSQET*IASSNSYPSHSPSPCPSTG
GSDRQTPRRRHRAQTTPSWPRGAGEDPSGCGSGA
EWLPEPLPLRAAR*GPRAWGQVSARLDPGQHAP
HLCLCQHPQVQPGPRPGRPHRA*GVGAGLSPHA
SAAALPEVPHGRARFQQ*GG*GLSQRWQRR*SPQ
ASSEATPDQNQAHSGSWTQLTPEAPNP*RDQSS
LTSAPGRYRH*GGTVRRTGQWGGRFWGHRG*AE
EGGRAEGTQTAPWPGGEWGRPVCRLHG*EHGQ*G
TPGAS*SASP*APRFLPGQALLSLRGVPWGRAA
ETHPIRHSLQWGARGQYE*PGSVCDHSTGMGSQ
L*GGPDGQPLPGIRSSPMDLQLQ*EAEVTSSPAL
WGGAASLKYVLYTHTHTHTHTHTHDAFNKDELV
LIQESPKTLRGSLGPGEECWAPPSEIW*RRNSL
SLLLGPLSLCWQEAGNWESDPQHCPSTFSGPLSH
TCILAVPLWLEAWVPMRLVSLLKP