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Sequences

Sequence XRCC1.fAug05

GCGGCCGCCGCCTCTCACCCAACGCACTACGACGCCCTCATCCTCGTCACCCCTGGGGCCCCCACTGAGAAGGACTGGGCCCAGGTCCAGGCCTTGCTGC TACCAGATGCGCCTCTTGTCTGCGTGCGCACAGACGGCGAGGGCGAGGATCCGGAGTGTCTGGGAGAAGTTGGAGAAGGAGGAGCAGATACACAGTGTGG ACATTGGGAATGATGGCTCAGCTTTCGTGGAGGTGCTGGTGGGCAGTTCAGCTGGAGGCGCTGGGGAGCAAGACTATGAGGTCCTTCTGGTCACCTCATC TTTCATGTCCCCTTCCGAGAGCCGCAGTGGCTCAAACCCCAACCGCGTTCGCATGTTTGGGCCTGACAAGCTGGTCCGGGCAGCCGCCGAGAAGCGCTGG GACCGGGTCAAAATTGTTTGCAGCCAGCCCTACAGCAAGGACTCCCCCTTTGGCTTGAGTTTTGTACGGTTTCATAGCCCCCCAGACAAAGATGAGGCAG AGGCCCCGTCCCAGAAGGTGACAGTGACCAAGCTTGGCCAGTTCCGTGTGAAGGAGGAGGATGAGAGCGCCAACTCTCTGAGGCCGGGGGCTCTCTTCTT CAGCCGGATCAACAAGACATCCCCAGCAAACCACCAGCCCAGCTGTCGCCATCTGTTCCCAAGAGACCTAAATTGCCAGCTCCAACTCGTACCCCAGCCA CAGCCCCAGTCCCTGCCCGAGCACAGGGGGCAGTGACAGGCAAACCCCGAGGAGAAGGCACCGAGCCCAGACGACCCCGAGCTGGCCCAGAGGAGCTGGG GAAGATCCTTCAGGGTGTGGTAGTGGTGCTGAGTGGCTTCCAGAACCCCTTCCGCTCCGAGCTGCGAGATAAGGCCCTAGAGCTTGGGGCCAAGTATCGG CCAGACTGGACCCGGGACAGCACGCACCTCATCTGTGCCTTTGCCAACACCCCCAAGTACAGCCAGGTCCTAGGCCTGGGAGGCCGCATCGTGCGTAAGG AGTGGGTGCTGGACTGTCACCGCATGCGTCGGCGGCTGCCCTCCCAGAGGTACCTCATGGCAGGGCCAGGTTCCAGCAGTGAGGAGGATGAGGCCTCTCA CAGCGGTGGCAGCGGAGATGAAGCCCCCAAGCTTCCTCAGAAGCAACCCCAGACCAAAACCAAGCCCACTCAGGCAGCTGGACCCAGCTCACCCCAGAAG CCCCCAACCCCTGAAGAGACCAAAGCAGCCTCACCAGTGCTCCAGGAAGATATAGACATTGAGGGGGTACAGTCAGAAGGACAGGACAATGGGGCGGAAG ATTCTGGGGACACAGAGGATGAGCTGAGGAGGGTGGCAGAGCAGAAGGAACACAGACTGCCCCCTGGCCAGGAGGAGAATGGGGAAGACCCGTATGCAGG CTCCACGGATGAGAACACGGACAGTGAGGAACACCAGGAGCCTCCTGATCTGCCAGTCCCTGAGCTCCCAGATTTCTTCCAGGGCAAGCACTTCTTTCTT TACGGGGAGTTCCCTGGGGACGAGCGGCGGAAACTCATCCGATACGTCACAGCCTTCAATGGGTGAGTCTCCAGGGAC

XRCC1.u.f.14 (forward primer)
XRCC1.u.r.18 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

AAAASHPTHYDALILVTPGAPTEKDWAQVQALL LPDAPLVCVRTDGEGEDPECLGEVGEGGADTQCG HWE*WLSFRGGAGGQFSWRRWGARL*GPSGHLI FHVPFREPQWLKPQPRSHVWA*QAGPGSRREAL GPGQNCLQPALQQGLPLWLEFCTVS*PPRQR*GR GPVPEGDSDQAWPVPCEGGG*ERQLSEAGGSLL QPDQQDIPSKPPAQLSPSVPKRPKLPAPTRTPA TAPVPARAQGAVTGKPRGEGTEPRRPRAGPEELG KILQGVVVVLSGFQNPFRSELRDKALELGAKYR PDWTRDSTHLICAFANTPKYSQVLGLGGRIVRK EWVLDCHRMRRRLPSQRYLMAGPGSSSEEDEASH SGGSGDEAPKLPQKQPQTKTKPTQAAGPSSPQK PPTPEETKAASPVLQEDIDIEGVQSEGQDNGAE DSGDTEDELRRVAEQKEHRLPPGQEENGEDPYAG STDENTDSEEHQEPPDLPVPELPDFFQGKHFFL YGEFPGDERRKLIRYVTAFNG*VSRD

Frame 1

RPPPLTQRTTTPSSSSPLGPPLRRTGPRSRPCC YQMRLLSACAQTARARIRSVWEKLEKEEQIHSV DIGNDGSAFVEVLVGSSAGGAGEQDYEVLLVTSS FMSPSESRSGSNPNRVRMFGPDKLVRAAAEKRW DRVKIVCSQPYSKDSPFGLSFVRFHSPPDKDEA EAPSQKVTVTKLGQFRVKEEDESANSLRPGALFF SRINKTSPANHQPSCRHLFPRDLNCQLQLVPQP QPQSLPEHRGQ*QANPEEKAPSPDDPELAQRSW GRSFRVW*WC*VASRTPSAPSCEIRP*SLGPSIG QTGPGTARTSSVPLPTPPSTARS*AWEAASCVR SGCWTVTACVGGCPPRGTSWQGQVPAVRRMRPL TAVAAEMKPPSFLRSNPRPKPSPLRQLDPAHPRS PQPLKRPKQPHQCSRKI*TLRGYSQKDRTMGRK ILGTQRMS*GGWQSRRNTDCPLARRRMGKTRMQ APRMRTRTVRNTRSLLICQSLSSQISSRASTSFF TGSSLGTSGGNSSDTSQPSMGESPG

Frame 2

GRRLSPNALRRPHPRHPWGPH*EGLGPGPGLAA TRCASCLRAHRRRGRGSGVSGRSWRRRSRYTVW TLGMMAQLSWRCWWAVQLEALGSKTMRSFWSPH LSCPLPRAAVAQTPTAFACLGLTSWSGQPPRSAG TGSKLFAASPTARTPPLA*VLYGFIAPQTKMRQ RPRPRR*Q*PSLASSV*RRRMRAPTL*GRGLSS SAGSTRHPQQTTSPAVAICSQET*IASSNSYPSH SPSPCPSTGGSDRQTPRRRHRAQTTPSWPRGAG EDPSGCGSGAEWLPEPLPLRAAR*GPRAWGQVS ARLDPGQHAPHLCLCQHPQVQPGPRPGRPHRA*G VGAGLSPHASAAALPEVPHGRARFQQ*GG*GLS QRWQRR*SPQASSEATPDQNQAHSGSWTQLTPE APNP*RDQSSLTSAPGRYRH*GGTVRRTGQWGGR FWGHRG*AEEGGRAEGTQTAPWPGGEWGRPVCR LHG*EHGQ*GTPGAS*SASP*APRFLPGQALLS LRGVPWGRAAETHPIRHSLQWVSLQG

Sequence XRCC1.aAug05

TCCCTTGGCCCCAGGAGACAGGGGTTGCAGAAAGCCGAGATCGTGCCACTGCACTCCATCCTGGGTGAGAGAGCAAGACCCTGTCTCAACAAAAAATTTT TAAAAAATAAAATAAATAATAATACAGCAAAAAGATTTGCTTTCTCGGCTTCAGTGTGGGCGGTAACTCCATCGTGCAATGAGAAAGGCGAATTTCTTCC AGACACCAATCCCGGAGGTCGCTTCTGTTGCTAGGCTCCCAGAAAGCAGGGTTCGGACGTCATTGGGAGGCGAGGCTAGAGCGGGGTTGTGTGTGGCGGA GGGAGGCGGGGCTGGAGGAAACGCTCGTTGCTAAGGAACGCAGCGCTCTTCCCGCTCTGGAGAGGCGCGACTGGGCTTGCGCAGTGTCGACGCCGGCGCC GGCGCGCCGGGGTTTGAAAGGCCCGAGCCTCGCGCGCTTGCGCACTTTAGCCAGCGCAGGGCGCACCCCGCCCCCTCCCACTCTCCCTGCCCCTCGGACC CCATACTCTACCTCATCCTTCTGGCCAGGCGAAGCCCACGACGTTGACATGCCGGAGATCCGCCTCCGCCATGTCGTGTCCTGCAGCAGCCAGGACTCGA CTCACTGTGCAGAAAATCTTCTCAAGGCAGACACTTACCGAAAATGGCGGGCAGCCAAGGCAGGCGAGAAGACCATCTCTGTGGTCCTACAGTTGGAGAA GGAGGAGCAGATACACAGTGTGGACATTGGGAATGATGGCTCAGCTTTCGTGGAGGTGCTGGTGGGCAGTTCAGCTGGAGGCGCTGGGGAGCAAGACTAT GAGGTCCTTCTGGTCACCTCATCTTTCATGTCCCCTTCCGAGAGCCGCAGTGGCTCAAACCCCAACCGCGTTCGCATGTTTGGGCCTGACAAGCTGGTCC GGGCAGCCGCCGAGAAGCGCTGGGACCGGGTCAAAATTGTTTGCAGCCAGCCCTACAGCAAGGACTCCCCCTTTGGCTTGAGTTTTGTACGGTTTCATAG CCCCCCAGACAAAGATGAGGCAGAGGCCCCGTCCCAGAAGGTGACAGTGACCAAGCTTGGCCAGTTCCGTGTGAAGGAGGAGGATGAGAGCGCCAACTCT CTGAGGCCGGGGGCTCTCTTCTTCAGCCGGATCAACAAGACATCCCCAGTCACAGCCAGCGACCCAGCAGGACCTAGCTATGCAGCTGCTACCCTCCAGG CTTCTAGTGCTGCCTCCTCAGCCTCTCCAGTCTCCAGGGCCATAGGCAGCACCTCCAAGCCCCAGGAGTCTCCCAAAGGGAAGAGGAAGTTGGATTTGAA CCAAGAAGAAAAGAAGACCCCCAGCAAACCACCAGCCCAGCTGTCGCCATCTGTTCCCAAGAGACCTAAATTGCCAGCTCCAACTCGTACCCCAGCCACA GCCCCAGTCCCTGCCCGAGCACAGGGGGCAGTGACAGGCAAACCCCGAGGAGAAGGCACCGAGCCCAGACGACCCCGAGCTGGCCCAGAGGAGCTGGGGA AGATCCTTCAGGGTGTGGTAGTGGTGCTGAGTGGCTTCCAGAACCCCTTCCGCTCCGAGCTGCGAGATAAGGCCCTAGAGCTTGGGGCCAAGTATCGGCC AGACTGGACCCGGGACAGCACGCACCTCATCTGTGCCTTTGCCAACACCCCCAAGTACAGCCAGGTCCTAGGCCTGGGAGGCCGCATCGTGCGTAAGGAG TGGGTGCTGGACTGTCACCGCATGCGTCGGCGGCTGCCCTCCCAGAGGTACCTCATGGCAGGGCCAGGTTCCAGCAGTGAGGAGGATGAGGCCTCTCACA GCGGTGGCAGCGGAGATGAAGCCCCCAAGCTTCCTCAGAAGCAACCCCAGACCAAAACCAAGCCCACTCAGGCAGCTGGACCCAGCTCACCCCAGAAGCC CCCAACCCCTGAAGAGACCAAAGCAGCCTCACCAGTGCTCCAGGAAGATATAGACATTGAGGGGGTACAGTCAGAAGGACAGGACAATGGGGCGGAAGAT TCTGGGGACACAGAGGATGAGCTGAGGAGGGTGGCAGAGCAGAAGGAACACAGACTGCCCCCTGGCCAGGAGGAGAATGGGGAAGACCCGTATGCAGGCT CCACGGATGAGAACACGGACAGTGAGGAACACCAGGAGCCTCCTGATCTGCCAGTCCCTGAGCTCCCAGATTTCTTCCAGGGCAAGCACTTCTTTCTTTA CGGGGAGTTCCCTGGGGACGAGCGGCGGAAACTCATCCGATACGTCACAGCCTTCAATGGGGAGCTCGAGGACAATATGAGTGACCGGGTTCAGTTTGTG ATCACAGCACAGGAATGGGATCCCAGCTTTGAGGAGGCCCTGATGGACAACCCCTCCCTGGCATTCGTTCGTCCCCGATGGATCTACAGTTGCAATGAGA AGCAGAAGTTACTTCCTCACCAGCTCTATGGGGTGGTGCCGCAAGCCTGAAGTATGTGCTATACACACACACACACACACACACACACACACACACACAC GATGCATTTAATAAAGATGAGTTGGTTCTCATCCAAGAGTCTCCCAAAACTCTAAGAGGCTCCCTGGGACCTGGGGAAGAATGCTGGGCACCTCCGTCAG AGATCTGGTAGAGAAGGAACTCTTTGTCTCTTCTGCTTGGCCCCTTATCCCTGTGTTGGCAAGAGGCAGGGAACTGGGAATCTGACCCTCAGCACTGCCC CTCAACTTTTTCTGGCCCTCTGAGCCACACCTGTATCTTGGCTGTCCCTTTGTGGCTGGAGGCCTGGGTACCCATGAGGCTTGTCTCTCTCCTGAAGCCT CA

XRCC1.u.f.14 (forward primer)
XRCC1.u.r.18 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

SLGPRRQGLQKAEIVPLHSILGERARPCLNKKF LKNKINNNTAKRFAFSASVWAVTPSCNEKGEFLP DTNPGGRFCC*APRKQGSDVIGRRG*SGVVCGG GRRGWRKRSLLRNAALFPLWRGATGLAQCRRRR RRAGV*KARASRACAL*PAQGAPRPLPLSLPLGP HTLPHPSGQAKPTTLTCRRSASAMSCPAAARTR LTVQKIFSRQTLTENGGQPRQARRPSLWSYSWR RRSRYTVWTLGMMAQLSWRCWWAVQLEALGSKTM RSFWSPHLSCPLPRAAVAQTPTAFACLGLTSWS GQPPRSAGTGSKLFAASPTARTPPLA*VLYGFI APQTKMRQRPRPRR*Q*PSLASSV*RRRMRAPTL *GRGLSSSAGSTRHPQSQPATQQDLAMQLLPSR LLVLPPQPLQSPGP*AAPPSPRSLPKGRGSWI* TKKKRRPPANHQPSCRHLFPRDLNCQLQLVPQPQ PQSLPEHRGQ*QANPEEKAPSPDDPELAQRSWG RSFRVW*WC*VASRTPSAPSCEIRP*SLGPSIG QTGPGTARTSSVPLPTPPSTARS*AWEAASCVRS GCWTVTACVGGCPPRGTSWQGQVPAVRRMRPLT AVAAEMKPPSFLRSNPRPKPSPLRQLDPAHPRS PQPLKRPKQPHQCSRKI*TLRGYSQKDRTMGRKI LGTQRMS*GGWQSRRNTDCPLARRRMGKTRMQA PRMRTRTVRNTRSLLICQSLSSQISSRASTSFF TGSSLGTSGGNSSDTSQPSMGSSRTI*VTGFSL* SQHRNGIPALRRP*WTTPPWHSFVPDGSTVAMR SRSYFLTSSMGWCRKPEVCAIHTHTHTHTHTHT RCI**R*VGSHPRVSQNSKRLPGTWGRMLGTSVR DLVEKELFVSSAWPLIPVLARGRELGI*PSALP LNFFWPSEPHLYLGCPFVAGGLGTHEACLSPEA S

Frame 1

PLAPGDRGCRKPRSCHCTPSWVREQDPVSTKNF *KIK*IIIQQKDLLSRLQCGR*LHRAMRKANFF QTPIPEVASVARLPESRVRTSLGGEARAGLCVAE GGGAGGNARC*GTQRSSRSGEARLGLRSVDAGA GAPGFERPEPRALAHFSQRRAHPAPSHSPCPSD PILYLILLARRSPRR*HAGDPPPPCRVLQQPGLD SLCRKSSQGRHLPKMAGSQGRREDHLCGPTVGE GGADTQCGHWE*WLSFRGGAGGQFSWRRWGARL *GPSGHLIFHVPFREPQWLKPQPRSHVWA*QAGP GSRREALGPGQNCLQPALQQGLPLWLEFCTVS* PPRQR*GRGPVPEGDSDQAWPVPCEGGG*ERQL SEAGGSLLQPDQQDIPSHSQRPSRT*LCSCYPPG F*CCLLSLSSLQGHRQHLQAPGVSQREEEVGFE PRRKEDPQQTTSPAVAICSQET*IASSNSYPSH SPSPCPSTGGSDRQTPRRRHRAQTTPSWPRGAGE DPSGCGSGAEWLPEPLPLRAAR*GPRAWGQVSA RLDPGQHAPHLCLCQHPQVQPGPRPGRPHRA*G VGAGLSPHASAAALPEVPHGRARFQQ*GG*GLSQ RWQRR*SPQASSEATPDQNQAHSGSWTQLTPEA PNP*RDQSSLTSAPGRYRH*GGTVRRTGQWGGR FWGHRG*AEEGGRAEGTQTAPWPGGEWGRPVCRL HG*EHGQ*GTPGAS*SASP*APRFLPGQALLSL RGVPWGRAAETHPIRHSLQWGARGQYE*PGSVC DHSTGMGSQL*GGPDGQPLPGIRSSPMDLQLQ*E AEVTSSPALWGGAASLKYVLYTHTHTHTHTHTH DAFNKDELVLIQESPKTLRGSLGPGEECWAPPS EIW*RRNSLSLLLGPLSLCWQEAGNWESDPQHCP STFSGPLSHTCILAVPLWLEAWVPMRLVSLLKP

Frame 2

PWPQETGVAESRDRATALHPG*ESKTLSQQKIF KK*NK**YSKKICFLGFSVGGNSIVQ*ERRISS RHQSRRSLLLLGSQKAGFGRHWEARLERGCVWR REAGLEETLVAKERSALPALERRDWACAVSTPAP ARRGLKGPSLARLRTLASAGRTPPPPTLPAPRT PYSTSSFWPGEAHDVDMPEIRLRHVVSCSSQDS THCAENLLKADTYRKWRAAKAGEKTISVVLQLEK EEQIHSVDIGNDGSAFVEVLVGSSAGGAGEQDY EVLLVTSSFMSPSESRSGSNPNRVRMFGPDKLV RAAAEKRWDRVKIVCSQPYSKDSPFGLSFVRFHS PPDKDEAEAPSQKVTVTKLGQFRVKEEDESANS LRPGALFFSRINKTSPVTASDPAGPSYAAATLQ ASSAASSASPVSRAIGSTSKPQESPKGKRKLDLN QEEKKTPSKPPAQLSPSVPKRPKLPAPTRTPAT APVPARAQGAVTGKPRGEGTEPRRPRAGPEELG KILQGVVVVLSGFQNPFRSELRDKALELGAKYRP DWTRDSTHLICAFANTPKYSQVLGLGGRIVRKE WVLDCHRMRRRLPSQRYLMAGPGSSSEEDEASH SGGSGDEAPKLPQKQPQTKTKPTQAAGPSSPQKP PTPEETKAASPVLQEDIDIEGVQSEGQDNGAED SGDTEDELRRVAEQKEHRLPPGQEENGEDPYAG STDENTDSEEHQEPPDLPVPELPDFFQGKHFFLY GEFPGDERRKLIRYVTAFNGELEDNMSDRVQFV ITAQEWDPSFEEALMDNPSLAFVRPRWIYSCNE KQKLLPHQLYGVVPQA*SMCYTHTHTHTHTHTHT MHLIKMSWFSSKSLPKL*EAPWDLGKNAGHLRQ RSGREGTLCLFCLAPYPCVGKRQGTGNLTLSTA PQLFLAL*ATPVSWLSLCGWRPGYP*GLSLS*SL

Sequence XRCC1.hAug05

TCCCAGCAACAGGCATCCTCCTCTCTCAGATCCTGCCATGGTCACTCCTCAGACCTCCCAACGAGGGTCTCTTGCTGCCCCTCTTGGCTATTTTCAGGTC TTGTTTAAGACTCACTGTGCAGAAAATCTTCTCAAGGCAGACACTTACCGAAAATGGCGGGCAGCCAAGGCAGGCGAGAAGACCATCTCTGTGGTCCTAC AGTTGGAGAAGGAGGAGCAGATACACAGTGTGGACATTGGGAATGATGGCTCAGCTTTCGTGGAGGTGCTGGTGGGCAGTTCAGCTGGAGGCGCTGGGGA GCAAGACTATGAGGTCCTTCTGGTCACCTCATCTTTCATGTCCCCTTCCGAGAGCCGCAGTGGCTCAAACCCCAACCGCGTTCGCATGTTTGGGCCTGAC AAGCTGGTCCGGGCAGCCGCCGAGAAGCGCTGGGACCGGGTCAAAATTGTTTGCAGCCAGCCCTACAGCAAGGACTCCCCCTTTGGCTTGAGTTTTGTAC GGTTTCATAGCCCCCCAGACAAAGATGAGGCAGAGGCCCCGTCCCAGAAGGTGACAGTGACCAAGCTTGGCCAGTTCCGTGTGAAGGAGGAGGATGAGAG CGCCAACTCTCTGAGGCCGGGGGCTCTCTTCTTCAGCCGGATCAACAAGACATCCCCAGTCACAGCCAGCGACCCAGCAGGACCTAGCTATGCAGCTGCT ACCCTCCAGGCTTCTAGTGCTGCCTCCTCAGCCTCTCCAGTCTCCAGGGCCATAGGCAGCACCTCCAAGCCCCAGGAGTCTCCCAAAGGGAAGAGGAAGT TGGATTTGAACCAAGAAGAAAAGAAGACCCCCAGCAAACCACCAGCCCAGCTGTCGCCATCTGTTCCCAAGAGACCTAAATTGCCAGCTCCAACTCGTAC CCCAGCCACAGCC

XRCC1.u.f.14 (forward primer)
XRCC1.u.r.18 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

SQQQASSSLRSCHGHSSDLPTRVSCCPSWLFSG LV*DSLCRKSSQGRHLPKMAGSQGRREDHLCGPT VGEGGADTQCGHWE*WLSFRGGAGGQFSWRRWG ARL*GPSGHLIFHVPFREPQWLKPQPRSHVWA* QAGPGSRREALGPGQNCLQPALQQGLPLWLEFCT VS*PPRQR*GRGPVPEGDSDQAWPVPCEGGG*E RQLSEAGGSLLQPDQQDIPSHSQRPSRT*LCSC YPPGF*CCLLSLSSLQGHRQHLQAPGVSQREEEV GFEPRRKEDPQQTTSPAVAICSQET*IASSNSY PSHS

Frame 1

PSNRHPPLSDPAMVTPQTSQRGSLAAPLGYFQV LFKTHCAENLLKADTYRKWRAAKAGEKTISVVL QLEKEEQIHSVDIGNDGSAFVEVLVGSSAGGAGE QDYEVLLVTSSFMSPSESRSGSNPNRVRMFGPD KLVRAAAEKRWDRVKIVCSQPYSKDSPFGLSFV RFHSPPDKDEAEAPSQKVTVTKLGQFRVKEEDES ANSLRPGALFFSRINKTSPVTASDPAGPSYAAA TLQASSAASSASPVSRAIGSTSKPQESPKGKRK LDLNQEEKKTPSKPPAQLSPSVPKRPKLPAPTRT PATA

Frame 2

PATGILLSQILPWSLLRPPNEGLLLPLLAIFRS CLRLTVQKIFSRQTLTENGGQPRQARRPSLWSY SWRRRSRYTVWTLGMMAQLSWRCWWAVQLEALG SKTMRSFWSPHLSCPLPRAAVAQTPTAFACLGLT SWSGQPPRSAGTGSKLFAASPTARTPPLA*VLY GFIAPQTKMRQRPRPRR*Q*PSLASSV*RRRMR APTL*GRGLSSSAGSTRHPQSQPATQQDLAMQLL PSRLLVLPPQPLQSPGP*AAPPSPRSLPKGRGS WI*TKKKRRPPANHQPSCRHLFPRDLNCQLQLV PQPQ

Sequence XRCC1.cAug05

XRCC1.u.f.14 (forward primer)
XRCC1.u.r.18 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

Frame 1

Frame 2

Sequence XRCC1.gAug05

XRCC1.u.f.14 (forward primer)
XRCC1.u.r.18 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

SLGPRRQGLQKAEIVPLHSILGERARPCLNKKF LKNKINNNTAKRFAFSASVWAVTPSCNEKGEFLP DTNPGGRFCC*APRKQGSDVIGRRG*SGVVCGG GRRGWRKRSLLRNAALFPLWRGATGLAQCRRRR RRAGV*KARASRACAL*PAQGAPRPLPLSLPLGP HTLPHPSGQAKPTTLTCRRSASAMSCPAAARTR LTVQKIFSRQTLTENGGQPRQARRPSLWSYSWR RRSRYTVWTLGMMAQLSWRCWWAVQLEALGSKTM RSFWSPHLSCPLPRAAVAQTPTAFACLGLTSWS GQPPRSAGTGSKLFAASPTARTPPLA*VLYGFI APQTKMRQRPRPRR*Q*PSLASSV*RRRMRAPTL *GRGLSSSAGSTRHPQSQPATQQDLAMQLLPSR LLVLPPQPLQSPGP*AAPPSPRSLPKGRGSWI* TKKKRRPPANHQPSCRHLFPRDLNVS*LDP

Frame 1

PLAPGDRGCRKPRSCHCTPSWVREQDPVSTKNF *KIK*IIIQQKDLLSRLQCGR*LHRAMRKANFF QTPIPEVASVARLPESRVRTSLGGEARAGLCVAE GGGAGGNARC*GTQRSSRSGEARLGLRSVDAGA GAPGFERPEPRALAHFSQRRAHPAPSHSPCPSD PILYLILLARRSPRR*HAGDPPPPCRVLQQPGLD SLCRKSSQGRHLPKMAGSQGRREDHLCGPTVGE GGADTQCGHWE*WLSFRGGAGGQFSWRRWGARL *GPSGHLIFHVPFREPQWLKPQPRSHVWA*QAGP GSRREALGPGQNCLQPALQQGLPLWLEFCTVS* PPRQR*GRGPVPEGDSDQAWPVPCEGGG*ERQL SEAGGSLLQPDQQDIPSHSQRPSRT*LCSCYPPG F*CCLLSLSSLQGHRQHLQAPGVSQREEEVGFE PRRKEDPQQTTSPAVAICSQET*M*AN*I

Frame 2

PWPQETGVAESRDRATALHPG*ESKTLSQQKIF KK*NK**YSKKICFLGFSVGGNSIVQ*ERRISS RHQSRRSLLLLGSQKAGFGRHWEARLERGCVWR REAGLEETLVAKERSALPALERRDWACAVSTPAP ARRGLKGPSLARLRTLASAGRTPPPPTLPAPRT PYSTSSFWPGEAHDVDMPEIRLRHVVSCSSQDS THCAENLLKADTYRKWRAAKAGEKTISVVLQLEK EEQIHSVDIGNDGSAFVEVLVGSSAGGAGEQDY EVLLVTSSFMSPSESRSGSNPNRVRMFGPDKLV RAAAEKRWDRVKIVCSQPYSKDSPFGLSFVRFHS PPDKDEAEAPSQKVTVTKLGQFRVKEEDESANS LRPGALFFSRINKTSPVTASDPAGPSYAAATLQ ASSAASSASPVSRAIGSTSKPQESPKGKRKLDLN QEEKKTPSKPPAQLSPSVPKRPKCELTRS

Sequence XRCC1.eAug05

GGCCTCCCAAAATGTTGGGATTACAGGCATGAGCCACTGCACCTGACCTCAGTCTTTTAAACTGTGATAGATACAGATTGCTGACAGTTTTAGTCTTGAG ATCTAGATTCAAGCCCCCAGCTCTTCCTCTTAATCGGTGACCTCAAGAAAATTGTTTCATTTCTCTAACCTGTTTTCTCATGTGTCCATTGGGAATAATG ACATCCAAGCCCGGAGTTGTGAAAATTCGGTGACATAATGTCTGCACAAGTGCTCTGTCAACATGTAGGTGTTTGTGTAGAGGGAGGGATTTGTGTTTTT ATTACTTAGTGGGTGATGATTCCACTGGGCTCTCTTATGATCAAGTGACTCCAGGGAAATCACATTTCATTCTGTTACCCCAGTTGCTGTGGAAACAGAG TGACTGGAGGCAGAAGAGACAGAACCTGTCTCTGGCCTGGGAGAGACTGAGGGAGTATTGCAGCGGTCACCAACATGTTGGAGAAGGAGGAGCAGATACA CAGTGTGGACATTGGGAATGATGGCTCAGCTTTCGTGGAGGTGCTGGTGGGCAGTTCAGCTGGAGGCGCTGGGGAGCAAGACTATGAGGTCCTTCTGGTC ACCTCATCTTTCATGTCCCCTTCCGAGAGCCGCAGTGGCTCAAACCCCAACCGCGTTCGCATGTTTGGGCCTGACAAGCTGGTCCGGGCAGCCGCCGAGA AGCGCTGGGACCGGGTCAAAATTGTTTGCAGCCAGCCCTACAGCAAGGACTCCCCCTTTGGCTTGAGTTTTGTACGGTTTCATAGCCCCCCAGACAAAGA TGAGGCAGAGGCCCCGTCCCAGAAGGTGACAGTGACCAAGCTTGGCCAGTTCCGTGTGAAGGAGGAGGATGAGAGCGCCAACTCTCTGAGGCCGGGGGCT CTCTTCTTCAGCCGGATCAACAAGACATCCCCAGTCACAGCCAGCGACCCAGCAGGACCTAGCTATGCAGCTGCTACCCTCCAGGCTTCTAGTGCTGCCT CCTCAGCCTCTCCAGTCTCCAGGGCCATAGGCAGCACCTCCAAGCCCCAGGAGTCTCCCAAAGGGAAGAGGAAGTTGGATTTGAACCAAGAAGAAAAGAA GACCCCCAGCAAACCACCAGCCCAGCTGTCGCCATCTGTTCCCAAGAGACCTAAATCACAGAGGATGAGCTGAGGAGGGTGGCAGAGCAGAAGGAACACA GACTGCCCCCTGGCCAGGAGGAGAATGGGGAAGACCCGTATGCAGGCTCCACGGATGAGAACACGGACAGTGAGGAACACCAGGAGCCTCCTGATCTGCC AGTCCCTGAGCTCCCAGATTTCTTCCAGGGCAAGCACTTCTTTCTTTACGGGGAGTTCCCTGGGGACGAGCGGCGGAAACTCATCCGATACGTCACAGCC TTCAATGGGGAGCTCGAGGACAATATGAGTGACCGGGTTCAGTTTGTGATCACAGCACAGGAATGGGATCCCAGCTTTGAGGAGGCCCTGATGGACAACC CCTCCCTGGCATTCGTTCGTCCCCGATGGATCTACAGTTGCAATGAGAAGCAGAAGTTACTTCCTCACCAGCTCTATGGGGTGGTGCCGCAAGCCTGAAG TATGTGCTATACACACACACACACACACACACACACACACACACACACGATGCATTTAATAAAGATGAGTTGGTTCTCATCCAAGAGTCTCCCAAAACTC TAAGAGGCTCCCTGGGACCTGGGGAAGAATGCTGGGCACCTCCGTCAGAGATCTGGTAGAGAAGGAACTCTTTGTCTCTTCTGCTTGGCCCCTTATCCCT GTGTTGGCAAGAGGCAGGGAACTGGGAATCTGACCCTCAGCACTGCCCCTCAACTTTTTCTGGCCCTCTGAGCCACACCTGTATCTTGGCTGTCCCTTTG TGGCTGGAGGCCTGGGTACCCATGAGGCTTGTCTCTCTCCTGAAGCCTCA

XRCC1.u.f.14 (forward primer)
XRCC1.u.r.18 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

GLPKCWDYRHEPLHLTSVF*TVIDTDC*QF*S* DLDSSPQLFLLIGDLKKIVSFL*PVFSCVHWE** HPSPEL*KFGDIMSAQVLCQHVGVCVEGGICVF IT*WVMIPLGSLMIK*LQGNHISFCYPSCCGNR VTGGRRDRTCLWPGRD*GSIAAVTNMLEKEEQIH SVDIGNDGSAFVEVLVGSSAGGAGEQDYEVLLV TSSFMSPSESRSGSNPNRVRMFGPDKLVRAAAE KRWDRVKIVCSQPYSKDSPFGLSFVRFHSPPDKD EAEAPSQKVTVTKLGQFRVKEEDESANSLRPGA LFFSRINKTSPVTASDPAGPSYAAATLQASSAA SSASPVSRAIGSTSKPQESPKGKRKLDLNQEEKK TPSKPPAQLSPSVPKRPKSQRMS*GGWQSRRNT DCPLARRRMGKTRMQAPRMRTRTVRNTRSLLIC QSLSSQISSRASTSFFTGSSLGTSGGNSSDTSQP SMGSSRTI*VTGFSL*SQHRNGIPALRRP*WTT PPWHSFVPDGSTVAMRSRSYFLTSSMGWCRKPE VCAIHTHTHTHTHTHTRCI**R*VGSHPRVSQNS KRLPGTWGRMLGTSVRDLVEKELFVSSAWPLIP VLARGRELGI*PSALPLNFFWPSEPHLYLGCPF VAGGLGTHEACLSPEAS

Frame 1

ASQNVGITGMSHCT*PQSFKL**IQIADSFSLE I*IQAPSSSS*SVTSRKLFHFSNLFSHVSIGNN DIQARSCENSVT*CLHKCSVNM*VFV*REGFVFL LLSG**FHWALL*SSDSREITFHSVTPVAVETE *LEAEETEPVSGLGETEGVLQRSPTCWRRRSRY TVWTLGMMAQLSWRCWWAVQLEALGSKTMRSFWS PHLSCPLPRAAVAQTPTAFACLGLTSWSGQPPR SAGTGSKLFAASPTARTPPLA*VLYGFIAPQTK MRQRPRPRR*Q*PSLASSV*RRRMRAPTL*GRGL SSSAGSTRHPQSQPATQQDLAMQLLPSRLLVLP PQPLQSPGP*AAPPSPRSLPKGRGSWI*TKKKR RPPANHQPSCRHLFPRDLNHRG*AEEGGRAEGTQ TAPWPGGEWGRPVCRLHG*EHGQ*GTPGAS*SA SP*APRFLPGQALLSLRGVPWGRAAETHPIRHS LQWGARGQYE*PGSVCDHSTGMGSQL*GGPDGQP LPGIRSSPMDLQLQ*EAEVTSSPALWGGAASLK YVLYTHTHTHTHTHTHDAFNKDELVLIQESPKT LRGSLGPGEECWAPPSEIW*RRNSLSLLLGPLSL CWQEAGNWESDPQHCPSTFSGPLSHTCILAVPL WLEAWVPMRLVSLLKP

Frame 2

PPKMLGLQA*ATAPDLSLLNCDRYRLLTVLVLR SRFKPPALPLNR*PQENCFISLTCFLMCPLGIM TSKPGVVKIR*HNVCTSALSTCRCLCRGRDLCF YYLVGDDSTGLSYDQVTPGKSHFILLPQLLWKQS DWRQKRQNLSLAWERLREYCSGHQHVGEGGADT QCGHWE*WLSFRGGAGGQFSWRRWGARL*GPSG HLIFHVPFREPQWLKPQPRSHVWA*QAGPGSRRE ALGPGQNCLQPALQQGLPLWLEFCTVS*PPRQR *GRGPVPEGDSDQAWPVPCEGGG*ERQLSEAGG SLLQPDQQDIPSHSQRPSRT*LCSCYPPGF*CCL LSLSSLQGHRQHLQAPGVSQREEEVGFEPRRKE DPQQTTSPAVAICSQET*ITEDELRRVAEQKEH RLPPGQEENGEDPYAGSTDENTDSEEHQEPPDLP VPELPDFFQGKHFFLYGEFPGDERRKLIRYVTA FNGELEDNMSDRVQFVITAQEWDPSFEEALMDN PSLAFVRPRWIYSCNEKQKLLPHQLYGVVPQA*S MCYTHTHTHTHTHTHTMHLIKMSWFSSKSLPKL *EAPWDLGKNAGHLRQRSGREGTLCLFCLAPYP CVGKRQGTGNLTLSTAPQLFLAL*ATPVSWLSLC GWRPGYP*GLSLS*SL