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Sequences

Sequence FN1.oAug05

GTGGCCACCAAATATGAAGTGAGTGTCTATGCTCTTAAGGACACTTTGACAAGCAGACCAGCTCAGGGAGTTGTCACCACTCTGGAGAATGTCAGCCCAC CAAGAAGGGCTCGTGTGACAGATGCTACTGAGACCACCATCACCATTAGCTGGAGAACCAAGACTGAGACGATCACTGGCTTCCAAGTTGATGCCGTTCC AGCCAATGGCCAGACTCCAATCCAGAGAACCATCAAGCCAGATGTCAGAAGCTACACCATCACAGGTTTACAACCAGGCACTGACTACAAGATCTACCTG TACACCTTGAATGACAATGCTCGGAGCTCCCCTGTGGTCATCGACGCCTCCACTGCCATTGATGCACCATCCAACCTGCGTTTCCTGGCCACCACACCCA ATTCCTTGCTGGTATCATGGCAGCCGCCACGTGCCAGGATTACCGGCTACATCATCAAGTATGAGAAGCCTGGGTCTCCTCCCAGAGAAGTGGTCCCTCG GCCCCGCCCTGGTGTCACAGAGGCTACTATTACTGGCCTGGAACCGGGAACCGAATATACAATTTATGTCATTGCCCTGAAGAATAATCAGAAGAGCGAG CCCCTGATTGGAAGGAAAAAGACAGGACAAGAAGCTCTCTCTCAGACAACCATCTCATGGGCCCCATTCCAGGACACTTCTGAGTACATCATTTCATGTC ATCCTGTTGGCACTGATGAAGAACCCTTACAGTCAACGAAGGCTTGAACCAACCTACGGATGACTCGTGCTTTGACCCCTACACAGTTTCCCATTATGCC GTTGGAGATGAGTGGGAACGAATGTCTGAATCAGGCTTTAAACTGTTGTGCCAGTGCTTAGGCTTTGGAAGTGGTCATTTCAGATGTGATTCATCTAGAT GGTGCCATGACAATGGTGTGAACTACAAGATTGGAGAGAAGTGGGACCGTCAGGGAGAAAATGGCCAGATGATGAGCTGCACATGTCTTGGGAACGGAAA AGGAGAATTCAAGTGTGACCCTCATGAGGCAACGTGTTATGATGATGGGAAGACATACCACGTAGGAGAACAGTGGCAGAAGGAATATCTCGGTGCCATT TGCTCCTGCACATGCTTTGGAGGCCAGCGGGTAAGACTGGATGTGCCAGGCTCCCTACAAGTTAGATAAGATAAAGGGTGGGCTCCTGCAAGGATGTGTC GTACACACAGGAGGGGCAGAGACCCTTCGGAAGTATTAAAATACCACATTTCCTGTTGGCATACAACTGCTGACATAGAGCTCTAGAGCAGCTCTATGTC TACCTTACATGCCATTCATTCTTTCTATTACTCTTAGTAGAAAGAATGAATGAATGGCATGTAGAGTACCAAAAACACAAGTCTTGAGTCATTCTTAATA GCAACACCTGTCATTTATATGATGTTAGAATCATTTTCCTAAGCTCCCTAGCATGTCAGAGATACTATTTACACTGAAAAATAGTGAAGCAGAGATACTA TTCAAATTAATTAGTGGTAAATAGAATGTGTTTCATTTCAGCCGGTTCTCCCCATCCTGGGCAGCCTGAGACCCTCCCCTCCCCTACTATTCTCAGGCTG CTTCTATTTTTCAGCAAAGTGTTAAGTGCAGTGTAGCTC

FN1.u.f.55 (forward primer)
FN1.u.r.66 (reverse primer)
Single exon skipping

Frame 0

VATKYEVSVYALKDTLTSRPAQGVVTTLENVSP PRRARVTDATETTITISWRTKTETITGFQVDAVP ANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYL YTLNDNARSSPVVIDASTAIDAPSNLRFLATTP NSLLVSWQPPRARITGYIIKYEKPGSPPREVVPR PRPGVTEATITGLEPGTEYTIYVIALKNNQKSE PLIGRKKTGQEALSQTTISWAPFQDTSEYIISC HPVGTDEEPLQSTKA*TNLRMTRALTPTQFPIMP LEMSGNECLNQALNCCASA*ALEVVISDVIHLD GAMTMV*TTRLERSGTVREKMAR**AAHVLGTE KENSSVTLMRQRVMMMGRHTT*ENSGRRNISVPF APAHALEASG*DWMCQAPYKLDKIKGGLLQGCV VHTGGAETLRKY*NTTFPVGIQLLT*SSRAALC LPYMPFILSITLSRKNE*MACRVPKTQVLSHS** QHLSFI*C*NHFPKLPSMSEILFTLKNSEAEIL FKLISGK*NVFHFSRFSPSWAA*DPPLPYYSQA ASIFQQSVKCSVA

Frame 1

WPPNMK*VSMLLRTL*QADQLRELSPLWRMSAH QEGLV*QMLLRPPSPLAGEPRLRRSLASKLMPF QPMARLQSREPSSQMSEATPSQVYNQALTTRSTC TP*MTMLGAPLWSSTPPLPLMHHPTCVSWPPHP IPCWYHGSRHVPGLPATSSSMRSLGLLPEKWSL GPALVSQRLLLLAWNREPNIQFMSLP*RIIRRAS P*LEGKRQDKKLSLRQPSHGPHSRTLLSTSFHV ILLALMKNPYSQRRLEPTYG*LVL*PLHSFPLC RWR*VGTNV*IRL*TVVPVLRLWKWSFQM*FI*M VP*QWCELQDWREVGPSGRKWPDDELHMSWERK RRIQV*PS*GNVL**WEDIPRRRTVAEGISRCH LLLHMLWRPAGKTGCARLPTS*IR*RVGSCKDVS YTQEGQRPFGSIKIPHFLLAYNC*HRALEQLYV YLTCHSFFLLLLVERMNEWHVEYQKHKS*VILN SNTCHLYDVRIIFLSSLACQRYYLH*KIVKQRYY SN*LVVNRMCFISAGSPHPGQPETLPSPTILRL LLFFSKVLSAV*L

Frame 2

GHQI*SECLCS*GHFDKQTSSGSCHHSGECQPT KKGSCDRCY*DHHHH*LENQD*DDHWLPS*CRS SQWPDSNPENHQARCQKLHHHRFTTRH*LQDLP VHLE*QCSELPCGHRRLHCH*CTIQPAFPGHHTQ FLAGIMAAATCQDYRLHHQV*EAWVSSQRSGPS APPWCHRGYYYWPGTGNRIYNLCHCPEE*SEER APDWKEKDRTRSSLSDNHLMGPIPGHF*VHHFMS SCWH**RTLTVNEGLNQPTDDSCFDPYTVSHYA VGDEWERMSESGFKLLCQCLGFGSGHFRCDSSR WCHDNGVNYKIGEKWDRQGENGQMMSCTCLGNGK GEFKCDPHEATCYDDGKTYHVGEQWQKEYLGAI CSCTCFGGQRVRLDVPGSLQVR*DKGWAPARMC RTHRRGRDPSEVLKYHISCWHTTADIEL*SSSMS TLHAIHSFYYS**KE*MNGM*STKNTSLESFLI ATPVIYMMLESFS*AP*HVRDTIYTEK**SRDT IQIN*W*IECVSFQPVLPILGSLRPSPPLLFSGC FYFSAKC*VQCS

Sequence FN1.nAug05

GTGGCCACCAAATATGAAGTGAGTGTCTATGCTCTTAAGGACACTTTGACAAGCAGACCAGCTCAGGGAGTTGTCACCACTCTGGAGAATGTCAGCCCAC CAAGAAGGGCTCGTGTGACAGATGCTACTGAGACCACCATCACCATTAGCTGGAGAACCAAGACTGAGACGATCACTGGCTTCCAAGTTGATGCCGTTCC AGCCAATGGCCAGACTCCAATCCAGAGAACCATCAAGCCAGATGTCAGAAGCTACACCATCACAGGTTTACAACCAGGCACTGACTACAAGATCTACCTG TACACCTTGAATGACAATGCTCGGAGCTCCCCTGTGGTCATCGACGCCTCCACTGCCATTGATGCACCATCCAACCTGCGTTTCCTGGCCACCACACCCA ATTCCTTGCTGGTATCATGGCAGCCGCCACGTGCCAGGATTACCGGCTACATCATCAAGTATGAGAAGCCTGGGTCTCCTCCCAGAGAAGTGGTCCCTCG GCCCCGCCCTGGTGTCACAGAGGCTACTATTACTGGCCTGGAACCGGGAACCGAATATACAATTTATGTCATTGCCCTGAAGAATAATCAGAAGAGCGAG CCCCTGATTGGAAGGAAAAAGACAGGACAAGAAGCTCTCTCTCAGACAACCATCTCATGGGCCCCATTCCAGGACACTTCTGAGTACATCATTTCATGTC ATCCTGTTGGCACTGATGAAGAACCCTTACAGTTCAGGGTTCCTGGAACTTCTACCAGTGCCACTCTGACAGGCCTCACCAGAGGTGCCACCTACAACGT CATAGTGGAGGCACTGAAAGACCAGCAGAGGCATAAGGTTCGGGAAGAGGTTGTTACCGTGGGCAACTCTGGATGGTGCCATGACAATGGTGTGAACTAC AAGATTGGAGAGAAGTGGGACCGTCAGGGAGAAAATGGCCAGATGATGAGCTGCACATGTCTTGGGAACGGAAAAGGAGAATTCAAGTGTGACCCTCATG AGGCAACGTGTTATGATGATGGGAAGACATACCACGTAGGAGAACAGTGGCAGAAGGAATATCTCGGTGCCATTTGCTCCTGCACATGCTTTGGAGGCCA GCGGGTAAGACTGGATGTGCCAGGCTCCCTACAAGTTAGATAAGATAAAGGGTGGGCTCCTGCAAGGATGTGTCGTACACACAGGAGGGGCAGAGACCCT TCGGAAGTATTAAAATACCACATTTCCTGTTGGCATACAACTGCTGACATAGAGCTCTAGAGCAGCTCTATGTCTACCTTACATGCCATTCATTCTTTCT ATTACTCTTAGTAGAAAGAATGAATGAATGGCATGTAGAGTACCAAAAACACAAGTCTTGAGTCATTCTTAATAGCAACACCTGTCATTTATATGATGTT AGAATCATTTTCCTAAGCTCCCTAGCATGTCAGAGATACTATTTACACTGAAAAATAGTGAAGCAGAGATACTATTCAAATTAATTAGTGGTAAATAGAA TGTGTTTCATTTCAGCCGGTTCTCCCCATCCTGGGCAGCCTGAGACCCTCCCCTCCCCTACTATTCTCAGGCTGCTTCTATTTTTCAGCAAAGTGTTAAG TGCAGTGTAGCTC

FN1.u.f.55 (forward primer)
FN1.u.r.66 (reverse primer)
Single exon skipping

Frame 0

VATKYEVSVYALKDTLTSRPAQGVVTTLENVSP PRRARVTDATETTITISWRTKTETITGFQVDAVP ANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYL YTLNDNARSSPVVIDASTAIDAPSNLRFLATTP NSLLVSWQPPRARITGYIIKYEKPGSPPREVVPR PRPGVTEATITGLEPGTEYTIYVIALKNNQKSE PLIGRKKTGQEALSQTTISWAPFQDTSEYIISC HPVGTDEEPLQFRVPGTSTSATLTGLTRGATYNV IVEALKDQQRHKVREEVVTVGNSGWCHDNGVNY KIGEKWDRQGENGQMMSCTCLGNGKGEFKCDPH EATCYDDGKTYHVGEQWQKEYLGAICSCTCFGGQ RVRLDVPGSLQVR*DKGWAPARMCRTHRRGRDP SEVLKYHISCWHTTADIEL*SSSMSTLHAIHSF YYS**KE*MNGM*STKNTSLESFLIATPVIYMML ESFS*AP*HVRDTIYTEK**SRDTIQIN*W*IE CVSFQPVLPILGSLRPSPPLLFSGCFYFSAKC* VQCS

Frame 1

WPPNMK*VSMLLRTL*QADQLRELSPLWRMSAH QEGLV*QMLLRPPSPLAGEPRLRRSLASKLMPF QPMARLQSREPSSQMSEATPSQVYNQALTTRSTC TP*MTMLGAPLWSSTPPLPLMHHPTCVSWPPHP IPCWYHGSRHVPGLPATSSSMRSLGLLPEKWSL GPALVSQRLLLLAWNREPNIQFMSLP*RIIRRAS P*LEGKRQDKKLSLRQPSHGPHSRTLLSTSFHV ILLALMKNPYSSGFLELLPVPL*QASPEVPPTT S*WRH*KTSRGIRFGKRLLPWATLDGAMTMV*TT RLERSGTVREKMAR**AAHVLGTEKENSSVTLM RQRVMMMGRHTT*ENSGRRNISVPFAPAHALEA SG*DWMCQAPYKLDKIKGGLLQGCVVHTGGAETL RKY*NTTFPVGIQLLT*SSRAALCLPYMPFILS ITLSRKNE*MACRVPKTQVLSHS**QHLSFI*C *NHFPKLPSMSEILFTLKNSEAEILFKLISGK*N VFHFSRFSPSWAA*DPPLPYYSQAASIFQQSVK CSVA

Frame 2

GHQI*SECLCS*GHFDKQTSSGSCHHSGECQPT KKGSCDRCY*DHHHH*LENQD*DDHWLPS*CRS SQWPDSNPENHQARCQKLHHHRFTTRH*LQDLP VHLE*QCSELPCGHRRLHCH*CTIQPAFPGHHTQ FLAGIMAAATCQDYRLHHQV*EAWVSSQRSGPS APPWCHRGYYYWPGTGNRIYNLCHCPEE*SEER APDWKEKDRTRSSLSDNHLMGPIPGHF*VHHFMS SCWH**RTLTVQGSWNFYQCHSDRPHQRCHLQR HSGGTERPAEA*GSGRGCYRGQLWMVP*QWCEL QDWREVGPSGRKWPDDELHMSWERKRRIQV*PS* GNVL**WEDIPRRRTVAEGISRCHLLLHMLWRP AGKTGCARLPTS*IR*RVGSCKDVSYTQEGQRP FGSIKIPHFLLAYNC*HRALEQLYVYLTCHSFFL LLLVERMNEWHVEYQKHKS*VILNSNTCHLYDV RIIFLSSLACQRYYLH*KIVKQRYYSN*LVVNR MCFISAGSPHPGQPETLPSPTILRLLLFFSKVLS AV*L

Sequence FN1.jAug05

CGGGGCGGGGACAGCCCGGCGGGTCTCTCCTCCCCCGCGCCCCGGGCCTCCAGAGGGGCGGGAGGGGACCGTCCCATATAAGCCCCGGCTCCCGGCGCTC GGACGCCCGCGCCGGCTGTGCTGCACAGGGGGAGGAGAGGGAACCCCAGGCGCGAGCGGGAAGAGGGGACCTGCAGCCACAACTTCTCTGGTCCTCTGCA TCCCTTCTGTCCCTCCACCCGTCCCCTTCCCCACCCTCTGGCCCCCACCTTCTTGGAGGCGACAACCCCCGGGAGGCATTAGAAGGGATTTTTCCCGCAG GTTGCGAAGGGAAGCAAACTTGGTGGCAACTTGCCTCCCGGTGCGGGCGTCTCTCCCCCACCGTCTCAACATGCTTAGGGGTCCGGGGCCCGGGCTGCTG CTGCTGGCCGTCCAGTGCCTGGGGACAGCGGTGCCCTCCACGGGAGCCTCGAAGAGCAAGAGGCAGGCTCAGCAAATGGTTCAGCCCCAGTCCCCGGTGG CTGTCAGTCAAAGCAAGCCCGGTTGTTATGACAATGGAAAACACTATCAGATAAATCAACAGTGGGAGCGGACCTACCTAGGCAATGCGTTGGTTTGTAC TTGTTATGGAGGAAGCCGAGGTTTTAACTGCGAGAGTAAACCTGAAGCTGAAGAGACTTGCTTTGACAAGTACACTGGGAACACTTACCGAGTGGGTGAC ACTTATGAGCGTCCTAAAGACTCCATGATCTGGGACTGTACCTGCATCGGGGCTGGGCGAGGGAGAATAAGCTGTACCATCGCAAACCGCTGCCATGAAG GGGGTCAGTCCTACAAGATTGGTGACACCTGGAGGAGACCACATGAGACTGGTGGTTACATGTTAGAGTGTGTGTGTCTTGGTAATGGAAAAGGAGAATG GACCTGCAAGCCCATAGCTGAGAAGTGTTTTGATCATGCTGCTGGGACTTCCTATGTGGTCGGAGAAACGTGGGAGAAGCCCTACCAAGGCTGGATGATG GTAGATTGTACTTGCCTGGGAGAAGGCAGCGGACGCATCACTTGCACTTCTAGAAATAGATGCAACGATCAGGACACAAGGACATCCTATAGAATTGGAG ACACCTGGAGCAAGAAGGATAATCGAGGAAACCTGCTCCAGTGCATCTGCACAGGCAACGGCCGAGGAGAGTGGAAGTGTGAGAGGCACACCTCTGTGCA GACCACATCGAGCGGATCTGGCCCCTTCACCGATGTTCGTGCAGCTGTTTACCAACCGCAGCCTCACCCCCAGCCTCCTCCCTATGGCCACTGTGTCACA GACAGTGGTGTGGTCTACTCTGTGGGGATGCAGTGGCTGAAGACACAAGGAAATAAGCAAATGCTTTGCACGTGCCTGGGCAACGGAGTCAGCTGCCAAG AGACAGCTGTAACCCAGACTTACGGTGGCAACTCAAATGGAGAGCCATGTGTCTTACCATTCACCTACAATGGCAGGACGTTCTACTCCTGCACCACAGA AGGGCGACAGGACGGACATCTTTGGTGCAGCACAACTTCGAATTATGAGCAGGACCAGAAATACTCTTTCTGCACAGACCACACTGTTTTGGTTCAGACT CGAGGAGGAAATTCCAATGGTGCCTTGTGCCACTTCCCCTTCCTATACAACAACCACAATTACACTGATTGCACTTCTGAGGGCAGAAGAGACAACATGA AGTGGTGTGGGACCACACAGAACTATGATGCCGACCAGAAGTTTGGGTTCTGCCCCATGGCTGCCCACGAGGAAATCTGCACAACCAATGAAGGGGTCAT GTACCGCATTGGAGATCAGTGGGATAAGCAGCATGACATGGGTCACATGATGAGGTGCACGTGTGTTGGGAATGGTCGTGGGGAATGGACATGCATTGCC TACTCGCAGCTTCGAGATCAGTGCATTGTTGATGACATCACTTACAATGTGAACGACACATTCCACAAGCGTCATGAAGAGGGGCACATGCTGAACTGTA CATGCTTCGGTCAGGGTCGGGGCAGGTGGAAGTGTGATCCCGTCGACCAATGCCAGGATTCAGAGACTGGGACGTTTTATCAAATTGGAGATTCATGGGA GAAGTATGTGCATGGTGTCAGATACCAGTGCTACTGCTATGGCCGTGGCATTGGGGAGTGGCATTGCCAACCTTTACAGACCTATCCAAGCTCAAGTGGT CCTGTCGAAGTATTTATCACTGAGACTCCGAGTCAGCCCAACTCCCACCCCATCCAGTGGAATGCACCACAGCCATCTCACATTTCCAAGTACATTCTCA GGTGGAGACCTAAAAATTCTGTAGGCCGTTGGAAGGAAGCTACCATACCAGGCCACTTAAACTCCTACACCATCAAAGGCCTGAAGCCTGGTGTGGTATA CGAGGGCCAGCTCATCAGCATCCAGCAGTACGGCCACCAAGAAGTGACTCGCTTTGACTTCACCACCACCAGCACCAGCACACCTGTGACCAGCAACACC GTGACAGGAGAGACGACTCCCTTTTCTCCTCTTGTGGCCACTTCTGAATCTGTGACCGAAATCACAGCCAGTAGCTTTGTGGTCTCCTGGGTCTCAGCTT CCGACACCGTGTCGGGATTCCGGGTGGAATATGAGCTGAGTGAGGAGGGAGATGAGCCACAGTACCTGGATCTTCCAAGCACAGCCACTTCTGTGAACAT CCCTGACCTGCTTCCTGGCCGAAAATACATTGTAAATGTCTATCAGATATCTGAGGATGGGGAGCAGAGTTTGATCCTGTCTACTTCACAAACAACAGCG CCTGATGCCCCTCCTGACACGACTGTGGACCAAGTTGATGACACCTCAATTGTTGTTCGCTGGAGCAGACCCCAGGCTCCCATCACAGGGTACAGAATAG TCTATTCGCCATCAGTAGAAGGTAGCAGCACAGAACTCAACCTTCCTGAAACTGCAAACTCCGTCACCCTCAGTGACTTGCAACCTGGTGTTCAGTATAA CATCACTATCTATGCTGTGGAAGAAAATCAAGAAAGTACACCTGTTGTCATTCAACAAGAAACCACTGGCACCCCACGCTCAGATACAGTGCCCTCTCCC AGGGACCTGCAGTTTGTGGAAGTGACAGACGTGAAGGTCACCATCATGTGGACACCGCCTGAGAGTGCAGTGACCGGCTACCGTGTGGATGTGATCCCCG TCAACCTGCCTGGCGAGCACGGGCAGAGGCTGCCCATCAGCAGGAACACCTTTGCAGAAGTCACCGGGCTGTCCCCTGGGGTCACCTATTACTTCAAAGT CTTTGCAGTGAGCCATGGGAGGGAGAGCAAGCCTCTGACTGCTCAACAGACAACCAAACTGGATGCTCCCACTAACCTCCAGTTTGTCAATGAAACTGAT TCTACTGTCCTGGTGAGATGGACTCCACCTCGGGCCCAGATAACAGGATACCGACTGACCGTGGGCCTTACCCGAAGAGGACAGCCCAGGCAGTACAATG TGGGTCCCTCTGTCTCCAAGTACCCACTGAGGAATCTGCAGCCTGCATCTGAGTACACCGTATCCCTCGTGGCCATAAAGGGCAACCAAGAGAGCCCCAA AGCCACTGGAGTCTTTACCACACTGCAGCCTGGGAGCTCTATTCCACCTTACAACACCGAGGTGACTGAGACCACCATTGTGATCACATGGACGCCTGCT CCAAGAATTGGTTTTAAGCTGGGTGTACGACCAAGCCAGGGAGGAGAGGCACCACGAGAAGTGACTTCAGACTCAGGAAGCATCGTTGTGTCCGGCTTGA CTCCAGGAGTAGAATACGTCTACACCATCCAAGTCCTGAGAGATGGACAGGAAAGAGATGCGCCAATTGTAAACAAAGTGGTGACACCATTGTCTCCACC AACAAACTTGCATCTGGAGGCAAACCCTGACACTGGAGTGCTCACAGTCTCCTGGGAGAGGAGCACCACCCCAGACATTACTGGTTATAGAATTACCACA ACCCCTACAAACGGCCAGCAGGGAAATTCTTTGGAAGAAGTGGTCCATGCTGATCAGAGCTCCTGCACTTTTGATAACCTGAGTCCCGGCCTGGAGTACA ATGTCAGTGTTTACACTGTCAAGGATGACAAGGAAAGTGTCCCTATCTCTGATACCATCATCCCAGCTGTTCCTCCTCCCACTGACCTGCGATTCACCAA CATTGGTCCAGACACCATGCGTGTCACCTGGGCTCCACCCCCATCCATTGATTTAACCAACTTCCTGGTGCGTTACTCACCTGTGAAAAATGAGGAAGAT GTTGCAGAGTTGTCAATTTCTCCTTCAGACAATGCAGTGGTCTTAACAAATCTCCTGCCTGGTACAGAATATGTAGTGAGTGTCTCCAGTGTCTACGAAC AACATGAGAGCACACCTCTTAGAGGAAGACAGAAAACAGGTCTTGATTCCCCAACTGGCATTGACTTTTCTGATATTACTGCCAACTCTTTTACTGTGCA CTGGATTGCTCCTCGAGCCACCATCACTGGCTACAGGATCCGCCATCATCCCGAGCACTTCAGTGGGAGACCTCGAGAAGATCGGGTGCCCCACTCTCGG AATTCCATCACCCTCACCAACCTCACTCCAGGCACAGAGTATGTGGTCAGCATCGTTGCTCTTAATGGCAGAGAGGAAAGTCCCTTATTGATTGGCCAAC AATCAACAGTTTCTGATGTTCCGAGGGACCTGGAAGTTGTTGCTGCGACCCCCACCAGCCTACTGATCAGCTGGGATGCTCCTGCTGTCACAGTGAGATA TTACAGGATCACTTACGGAGAGACAGGAGGAAATAGCCCTGTCCAGGAGTTCACTGTGCCTGGGAGCAAGTCTACAGCTACCATCAGCGGCCTTAAACCT GGAGTTGATTATACCATCACTGTGTATGCTGTCACTGGCCGTGGAGACAGCCCCGCAAGCAGCAAGCCAATTTCCATTAATTACCGAACAGAAATTGACA AACCATCCCAGATGCAAGTGACCGATGTTCAGGACAACAGCATTAGTGTCAAGTGGCTGCCTTCAAGTTCCCCTGTTACTGGTTACAGAGTAACCACCAC TCCCAAAAATGGACCAGGACCAACAAAAACTAAAACTGCAGGTCCAGATCAAACAGAAATGACTATTGAAGGCTTGCAGCCCACAGTGGAGTATGTGGTT AGTGTCTATGCTCAGAATCCAAGCGGAGAGAGTCAGCCTCTGGTTCAGACTGCAGTAACCACTATTCCTGCACCAACTGACCTGAAGTTCACTCAGGTCA CACCCACAAGCCTGAGCGCCCAGTGGACACCACCCAATGTTCAGCTCACTGGATATCGAGTGCGGGTGACCCCCAAGGAGAAGACCGGACCAATGAAAGA AATCAACCTTGCTCCTGACAGCTCATCCGTGGTTGTATCAGGACTTATGGTGGCCACCAAATATGAAGTGAGTGTCTATGCTCTTAAGGACACTTTGACA AGCAGACCAGCTCAGGGAGTTGTCACCACTCTGGAGAATGTCAGCCCACCAAGAAGGGCTCGTGTGACAGATGCTACTGAGACCACCATCACCATTAGCT GGAGAACCAAGACTGAGACGATCACTGGCTTCCAAGTTGATGCCGTTCCAGCCAATGGCCAGACTCCAATCCAGAGAACCATCAAGCCAGATGTCAGAAG CTACACCATCACAGGTTTACAACCAGGCACTGACTACAAGATCTACCTGTACACCTTGAATGACAATGCTCGGAGCTCCCCTGTGGTCATCGACGCCTCC ACTGCCATTGATGCACCATCCAACCTGCGTTTCCTGGCCACCACACCCAATTCCTTGCTGGTATCATGGCAGCCGCCACGTGCCAGGATTACCGGCTACA TCATCAAGTATGAGAAGCCTGGGTCTCCTCCCAGAGAAGTGGTCCCTCGGCCCCGCCCTGGTGTCACAGAGGCTACTATTACTGGCCTGGAACCGGGAAC CGAATATACAATTTATGTCATTGCCCTGAAGAATAATCAGAAGAGCGAGCCCCTGATTGGAAGGAAAAAGACAGGACAAGAAGCTCTCTCTCAGACAACC ATCTCATGGGCCCCATTCCAGGACACTTCTGAGTACATCATTTCATGTCATCCTGTTGGCACTGATGAAGAACCCTTACAGTTCAGGGTTCCTGGAACTT CTACCAGTGCCACTCTGACAGGCCTCACCAGAGGTGCCACCTACAACGTCATAGTGGAGGCACTGAAAGACCAGCAGAGGCATAAGGTTCGGGAAGAGGT TGTTACCGTGGGCAACTCTGTCAACGAAGGCTTGAACCAACCTACGGATGACTCGTGCTTTGACCCCTACACAGTTTCCCATTATGCCGTTGGAGATGAG TGGGAACGAATGTCTGAATCAGGCTTTAAACTGTTGTGCCAGTGCTTAGGCTTTGGAAGTGGTCATTTCAGATGTGATTCATCTAGATGGTGCCATGACA ATGGTGTGAACTACAAGATTGGAGAGAAGTGGGACCGTCAGGGAGAAAATGGCCAGATGATGAGCTGCACATGTCTTGGGAACGGAAAAGGAGAATTCAA GTGTGACCCTCATGAGGCAACGTGTTATGATGATGGGAAGACATACCACGTAGGAGAACAGTGGCAGAAGGAATATCTCGGTGCCATTTGCTCCTGCACA TGCTTTGGAGGCCAGCGGGGCTGGCGCTGTGACAACTGCCGCAGACCTGGGGGTGAACCCAGTCCCGAAGGCACTACTGGCCAGTCCTACAACCAGTATT CTCAGAGATACCATCAGAGAACAAACACTAATGTTAATTGCCCAATTGAGTGCTTCATGCCTTTAGATGTACAGGCTGACAGAGAAGATTCCCGAGAGTA AATCATCTTTCCAATCCAGAGGAACAAGCATGTCTCTCTGCCAAGATCCATCTAAACTGGAGTGATGTTAGCAGACCCAGCTTAGAGTTCTTCTTTCTTT CTTAAGCCCTTTGCTCTGGAGGAAGTTCTCCAGCTTCAGCTCAACTCACAGCTTCTCCAAGCATCACCCTGGGAGTTTCCTGAGGGTTTTCTCATAAATG AGGGCTGCACATTGCCTGTTCTGCTTCGAAGTATTCAATACCGCTCAGTATTTTAAATGAAGTGATTCTAAGATTTGGTTTGGGATCAATAGGAAAGCAT ATGCAGCCAACCAAGATGCAAATGTTTTGAAATGATATGACCAAAATTTTAAGTAGGAAAGTCACCCAAACACTTCTGCTTTCACTTAAGTGTCTGGCCC GCAATACTGTAGGAACAAGCATGATCTTGTTACTGTGATATTTTAAATATCCACAGTACTCACTTTTTCCAAATGATCCTAGTAATTGCCTAGAAATATC TTTCTCTTACCTGTTATTTATCAATTTTTCCCAGTATTTTTATACGGAAAAAATTGTATTGAAAACACTTAGTATGCAGTTGATAAGAGGAATTTGGTAT AATTATGGTGGGTGATTATTTTTTATACTGTATGTGCCAAAGCTTTACTACTGTGGAAAGACAACTGTTTTAATAAAAGATTTACATTCCACAACTTGAA GTTCATCTATTTGATATAAGACACCTTCGGGGGAAATAATTCCTGTGAATATTCTTTTTCAATTCAGCAAACATTTGAAAATCTATGATGTGCAAGTCTA ATTGTTGATTTCAGTACAAGATTTTCTAAATCAGTTGCTACAAAAACTGATTGGTTTTTGTCACTTCATCTCTTCACTAATGGAGATAGCTTTACACTTT CTGCTTTAATAGATTTAAGTGGACCCCAATATTTATTAAAATTGCTAGTTTACCGTTCAGAAGTATAATAGAAATAATCTTTAGTTGCTCTTTTCTAACC ATTGTAATTCTTCCCTTCTTCCCTCCACCTTTCCTTCATTGAATAAACCTCTGTTCAAAGAGATTGCCTGCAAGGGAAATAAAAATGACTAAGATATTAA AAGTATTTGAATAGTATAATATGGAGGAGTTTTATCTTAGGGAAACCCCATGGTATGATAACCCCCATCTAACATGTCTTACTTTGGGTCAGCTGACACT TTTGGCATGGCTTGATAAACTCCCAGCTAAACAGTTTGTTTACTCCTGATCTGTAAAGGTCATTTCTTTTTCAATTTAACATTGAGGAAACAAACTTTGG GATTAAATTTGACATTCAGGCCAGGCGCAGTGGCTCACACCTCTAATCCCAGCACTTTGGGAGGCTGAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGA GACCAGCCTGGCCAACATGGTGAAACCTTGTCTCTATTAAAAATACAAATGTTACCAGGCATGGCAGTGGGCGTCTTTGGTCCCGGCTACTCAGAAGGCT GAGGTAGGAGAATGGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCTGAGATTGTGCCATTGAACTCCAGCATGGGGGACAGAGCAAGACTCCATCCCA AAAAACATAAATAAATAAATGTGACATTCAGAATAGTAAATAGTGGAAATGGAAATAATTATTAGTAAAAAATTAGTAGTTCATAATAAACAAGACATGC AAAGCACTTTTTAAATATACTAATGTACAATGAAAGAAGGTATTTCAATAAACACCTGGCAAAGAATATTAAAACTAAATACAGAAAGATACTTCCTCAT GTTCATTTGAAAAAAAAAAATACTAACTCCCATTTGAATTGATTTACAGTTTATAAAATGCTTTGACATTTAGCTATCTCATTTAGGGGAGGTTTTAGAG CTTAATTTTACAGGGCATGAAGCTCAGATGAGGTTTCCTTAGCGAAATACAGACCCAGCCCCTGGACTTCTATTTATTACTGATCTTTAAGCTTTATCAG CCCAATAGTCACCAAGAGAGCTGCTCTGTATGTTTTTTAAAAATCACAGAAAGTACAAAATAAAGGTGATATTAAACGACTGTC

FN1.u.f.55 (forward primer)
FN1.u.r.66 (reverse primer)
Single exon skipping

Frame 0

RGGDSPAGLSSPAPRASRGAGGDRPI*APAPGA RTPAPAVLHRGRRGNPRREREEGTCSHNFSGPLH PFCPSTRPLPHPLAPTFLEATTPGRH*KGFFPQ VAKGSKLGGNLPPGAGVSPPPSQHA*GSGARAA AAGRPVPGDSGALHGSLEEQEAGSANGSAPVPGG CQSKQARLL*QWKTLSDKSTVGADLPRQCVGLY LLWRKPRF*LRE*T*S*RDLL*QVHWEHLPSG* HL*AS*RLHDLGLYLHRGWARENKLYHRKPLP*R GSVLQDW*HLEETT*DWWLHVRVCVSW*WKRRM DLQAHS*EVF*SCCWDFLCGRRNVGEALPRLDD GRLYLPGRRQRTHHLHF*K*MQRSGHKDIL*NWR HLEQEG*SRKPAPVHLHRQRPRRVEV*EAHLCA DHIERIWPLHRCSCSCLPTAASPPASSLWPLCH RQWCGLLCGDAVAEDTRK*ANALHVPGQRSQLPR DSCNPDLRWQLKWRAMCLTIHLQWQDVLLLHHR RATGRTSLVQHNFEL*AGPEILFLHRPHCFGSD SRRKFQWCLVPLPLPIQQPQLH*LHF*GQKRQHE VVWDHTEL*CRPEVWVLPHGCPRGNLHNQ*RGH VPHWRSVG*AA*HGSHDEVHVCWEWSWGMDMHC LLAASRSVHC**HHLQCERHIPQAS*RGAHAELY MLRSGSGQVEV*SRRPMPGFRDWDVLSNWRFMG EVCAWCQIPVLLLWPWHWGVALPTFTDLSKLKW SCRSIYH*DSESAQLPPHPVECTTAISHFQVHSQ VET*KFCRPLEGSYHTRPLKLLHHQRPEAWCGI RGPAHQHPAVRPPRSDSL*LHHHQHQHTCDQQH RDRRDDSLFSSCGHF*ICDRNHSQ*LCGLLGLSF RHRVGIPGGI*AE*GGR*ATVPGSSKHSHFCEH P*PASWPKIHCKCLSDI*GWGAEFDPVYFTNNS A*CPS*HDCGPS**HLNCCSLEQTPGSHHRVQNS LFAISRR*QHRTQPS*NCKLRHPQ*LATWCSV* HHYLCCGRKSRKYTCCHSTRNHWHPTLRYSALS QGPAVCGSDRREGHHHVDTA*ECSDRLPCGCDPR QPAWRARAEAAHQQEHLCRSHRAVPWGHLLLQS LCSEPWEGEQASDCSTDNQTGCSH*PPVCQ*N* FYCPGEMDSTSGPDNRIPTDRGPYPKRTAQAVQC GSLCLQVPTEESAACI*VHRIPRGHKGQPREPQ SHWSLYHTAAWELYSTLQHRGD*DHHCDHMDAC SKNWF*AGCTTKPGRRGTTRSDFRLRKHRCVRLD SRSRIRLHHPSPERWTGKRCANCKQSGDTIVST NKLASGGKP*HWSAHSLLGEEHHPRHYWL*NYH NPYKRPAGKFFGRSGPC*SELLHF**PESRPGVQ CQCLHCQG*QGKCPYL*YHHPSCSSSH*PAIHQ HWSRHHACHLGSTPIH*FNQLPGALLTCEK*GR CCRVVNFSFRQCSGLNKSPAWYRICSECLQCLRT T*EHTS*RKTENRS*FPNWH*LF*YYCQLFYCA LDCSSSHHHWLQDPPSSRALQWETSRRSGAPLS EFHHPHQPHSRHRVCGQHRCS*WQRGKSLIDWPT INSF*CSEGPGSCCCDPHQPTDQLGCSCCHSEI LQDHLRRDRRK*PCPGVHCAWEQVYSYHQRP*T WS*LYHHCVCCHWPWRQPRKQQANFH*LPNRN*Q TIPDASDRCSGQQH*CQVAAFKFPCYWLQSNHH SQKWTRTNKN*NCRSRSNRNDY*RLAAHSGVCG *CLCSESKRRESASGSDCSNHYSCTN*PEVHSGH THKPERPVDTTQCSAHWISSAGDPQGEDRTNER NQPCS*QLIRGCIRTYGGHQI*SECLCS*GHFD KQTSSGSCHHSGECQPTKKGSCDRCY*DHHHH*L ENQD*DDHWLPS*CRSSQWPDSNPENHQARCQK LHHHRFTTRH*LQDLPVHLE*QCSELPCGHRRL HCH*CTIQPAFPGHHTQFLAGIMAAATCQDYRLH HQV*EAWVSSQRSGPSAPPWCHRGYYYWPGTGN RIYNLCHCPEE*SEERAPDWKEKDRTRSSLSDN HLMGPIPGHF*VHHFMSSCWH**RTLTVQGSWNF YQCHSDRPHQRCHLQRHSGGTERPAEA*GSGRG CYRGQLCQRRLEPTYG*LVL*PLHSFPLCRWR* VGTNV*IRL*TVVPVLRLWKWSFQM*FI*MVP*Q WCELQDWREVGPSGRKWPDDELHMSWERKRRIQ V*PS*GNVL**WEDIPRRRTVAEGISRCHLLLH MLWRPAGLAL*QLPQTWG*TQSRRHYWPVLQPVF SEIPSENKH*C*LPN*VLHAFRCTG*QRRFPRV NHLSNPEEQACLSAKIHLNWSDVSRPSLEFFFL S*ALCSGGSSPASAQLTASPSITLGVS*GFSHK* GLHIACSASKYSIPLSILNEVILRFGLGSIGKH MQPTKMQMF*NDMTKILSRKVTQTLLLSLKCLA RNTVGTSMILLL*YFKYPQYSLFPNDPSNCLEIS FSYLLFINFSQYFYTEKIVLKTLSMQLIRGIWY NYGG*LFFILYVPKLYYCGKTTVLIKDLHSTT* SSSI*YKTPSGEIIPVNILFQFSKHLKIYDVQV* LLISVQDFLNQLLQKLIGFCHFISSLMEIALHF LL**I*VDPNIY*NC*FTVQKYNRNNL*LLFSN HCNSSLLPSTFPSLNKPLFKEIACKGNKND*DIK SI*IV*YGGVLS*GNPMV**PPSNMSYFGSADT FGMA**TPS*TVCLLLICKGHFFFNLTLRKQTL GLNLTFRPGAVAHTSNPSTLGG*GRWIT*GQEFE TSLANMVKPCLY*KYKCYQAWQWASLVPATQKA EVGEWLEPRRRRLQ*AEIVPLNSSMGDRARLHP KKHK*INVTFRIVNSGNGNNY**KISSS**TRHA KHFLNILMYNERRYFNKHLAKNIKTKYRKILPH VHLKKKNTNSHLN*FTVYKML*HLAISFRGGFR A*FYRA*SSDEVSLAKYRPSPWTSIYY*SLSFIS PIVTKRAALYVF*KSQKVQNKGDIKRL

Frame 1

GAGTARRVSPPPRPGPPEGREGTVPYKPRLPAL GRPRRLCCTGGGEGTPGASGKRGPAATTSLVLC IPSVPPPVPFPTLWPPPSWRRQPPGGIRRDFSRR LRREANLVATCLPVRASLPHRLNMLRGPGPGLL LLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPV AVSQSKPGCYDNGKHYQINQQWERTYLGNALVCT CYGGSRGFNCESKPEAEETCFDKYTGNTYRVGD TYERPKDSMIWDCTCIGAGRGRISCTIANRCHE GGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEW TCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMM VDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIG DTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQ TTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVT DSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQ ETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTE GRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQT RGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNM KWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVM YRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIA YSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNC TCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWE KYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSG PVEVFITETPSQPNSHPIQWNAPQPSHISKYIL RWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVY EGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNT VTGETTPFSPLVATSESVTEITASSFVVSWVSA SDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNI PDLLPGRKYIVNVYQISEDGEQSLILSTSQTTA PDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRI VYSPSVEGSSTELNLPETANSVTLSDLQPGVQYN ITIYAVEENQESTPVVIQQETTGTPRSDTVPSP RDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIP VNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKV FAVSHGRESKPLTAQQTTKLDAPTNLQFVNETD STVLVRWTPPRAQITGYRLTVGLTRRGQPRQYN VGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPK ATGVFTTLQPGSSIPPYNTEVTETTIVITWTPA PRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGL TPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPP TNLHLEANPDTGVLTVSWERSTTPDITGYRITT TPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEY NVSVYTVKDDKESVPISDTIIPAVPPPTDLRFTN IGPDTMRVTWAPPPSIDLTNFLVRYSPVKNEED VAELSISPSDNAVVLTNLLPGTEYVVSVSSVYE QHESTPLRGRQKTGLDSPTGIDFSDITANSFTVH WIAPRATITGYRIRHHPEHFSGRPREDRVPHSR NSITLTNLTPGTEYVVSIVALNGREESPLLIGQ QSTVSDVPRDLEVVAATPTSLLISWDAPAVTVRY YRITYGETGGNSPVQEFTVPGSKSTATISGLKP GVDYTITVYAVTGRGDSPASSKPISINYRTEID KPSQMQVTDVQDNSISVKWLPSSSPVTGYRVTTT PKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVV SVYAQNPSGESQPLVQTAVTTIPAPTDLKFTQV TPTSLSAQWTPPNVQLTGYRVRVTPKEKTGPMKE INLAPDSSSVVVSGLMVATKYEVSVYALKDTLT SRPAQGVVTTLENVSPPRRARVTDATETTITIS WRTKTETITGFQVDAVPANGQTPIQRTIKPDVRS YTITGLQPGTDYKIYLYTLNDNARSSPVVIDAS TAIDAPSNLRFLATTPNSLLVSWQPPRARITGY IIKYEKPGSPPREVVPRPRPGVTEATITGLEPGT EYTIYVIALKNNQKSEPLIGRKKTGQEALSQTT ISWAPFQDTSEYIISCHPVGTDEEPLQFRVPGT STSATLTGLTRGATYNVIVEALKDQQRHKVREEV VTVGNSVNEGLNQPTDDSCFDPYTVSHYAVGDE WERMSESGFKLLCQCLGFGSGHFRCDSSRWCHD NGVNYKIGEKWDRQGENGQMMSCTCLGNGKGEFK CDPHEATCYDDGKTYHVGEQWQKEYLGAICSCT CFGGQRGWRCDNCRRPGGEPSPEGTTGQSYNQY SQRYHQRTNTNVNCPIECFMPLDVQADREDSRE* IIFPIQRNKHVSLPRSI*TGVMLADPA*SSSFF LKPFALEEVLQLQLNSQLLQASPWEFPEGFLIN EGCTLPVLLRSIQYRSVF*MK*F*DLVWDQ*ESI CSQPRCKCFEMI*PKF*VGKSPKHFCFHLSVWP AIL*EQA*SCYCDILNIHSTHFFQMILVIA*KY LSLTCYLSIFPSIFIRKKLY*KHLVCS**EEFGI IMVGDYFLYCMCQSFTTVERQLF**KIYIPQLE VHLFDIRHLRGK*FL*IFFFNSANI*KSMMCKS NC*FQYKIF*ISCYKN*LVFVTSSLH*WR*LYTF CFNRFKWTPIFIKIASLPFRSIIEIIFSCSFLT IVILPFFPPPFLH*INLCSKRLPAREIKMTKIL KVFE*YNMEEFYLRETPWYDNPHLTCLTLGQLTL LAWLDKLPAKQFVYS*SVKVISFSI*H*GNKLW D*I*HSGQAQWLTPLIPALWEAEAGGSPEVRSL RPAWPTW*NLVSIKNTNVTRHGSGRLWSRLLRRL R*ENGLNPEGGGCSELRLCH*TPAWGTEQDSIP KNINK*M*HSE**IVEMEIIISKKLVVHNKQDM QSTF*IY*CTMKEGISINTWQRILKLNTERYFLM FI*KKKILTPI*IDLQFIKCFDI*LSHLGEVLE LNFTGHEAQMRFP*RNTDPAPGLLFITDL*ALS AQ*SPRELLCMFFKNHRKYKIKVILNDC

Frame 2

GRGQPGGSLLPRAPGLQRGGRGPSHISPGSRRS DARAGCAAQGEEREPQARAGRGDLQPQLLWSSA SLLSLHPSPSPPSGPHLLGGDNPREALEGIFPA GCEGKQTWWQLASRCGRLSPTVSTCLGVRGPGCC CWPSSAWGQRCPPREPRRARGRLSKWFSPSPRW LSVKASPVVMTMENTIR*INSGSGPT*AMRWFV LVMEEAEVLTARVNLKLKRLALTSTLGTLTEWVT LMSVLKTP*SGTVPASGLGEGE*AVPSQTAAMK GVSPTRLVTPGGDHMRLVVTC*SVCVLVMEKEN GPASP*LRSVLIMLLGLPMWSEKRGRSPTKAG*W *IVLAWEKAADASLALLEIDATIRTQGHPIELE TPGARRIIEETCSSASAQATAEESGSVRGTPLC RPHRADLAPSPMFVQLFTNRSLTPSLLPMATVSQ TVVWSTLWGCSG*RHKEISKCFARAWATESAAK RQL*PRLTVATQMESHVSYHSPTMAGRSTPAPQ KGDRTDIFGAAQLRIMSRTRNTLSAQTTLFWFRL EEEIPMVPCATSPSYTTTTITLIALLRAEETT* SGVGPHRTMMPTRSLGSAPWLPTRKSAQPMKGS CTALEISGISSMTWVT**GARVLGMVVGNGHALP TRSFEISALLMTSLTM*TTHSTSVMKRGTC*TV HASVRVGAGGSVIPSTNARIQRLGRFIKLEIHG RSMCMVSDTSATAMAVALGSGIANLYRPIQAQVV LSKYLSLRLRVSPTPTPSSGMHHSHLTFPSTFS GGDLKIL*AVGRKLPYQAT*TPTPSKA*SLVWY TRASSSASSSTATKK*LALTSPPPAPAHL*PATP *QERRLPFLLLWPLLNL*PKSQPVALWSPGSQL PTPCRDSGWNMS*VRREMSHSTWIFQAQPLL*T SLTCFLAENTL*MSIRYLRMGSRV*SCLLHKQQR LMPLLTRLWTKLMTPQLLFAGADPRLPSQGTE* SIRHQ*KVAAQNSTFLKLQTPSPSVTCNLVFSI TSLSMLWKKIKKVHLLSFNKKPLAPHAQIQCPLP GTCSLWK*QT*RSPSCGHRLRVQ*PATVWM*SP STCLASTGRGCPSAGTPLQKSPGCPLGSPITSK SLQ*AMGGRASL*LLNRQPNWMLPLTSSLSMKLI LLSW*DGLHLGPR*QDTD*PWALPEEDSPGSTM WVPLSPSTH*GICSLHLSTPYPSWP*RATKRAP KPLESLPHCSLGALFHLTTPR*LRPPL*SHGRLL QELVLSWVYDQAREERHHEK*LQTQEASLCPA* LQE*NTSTPSKS*EMDRKEMRQL*TKW*HHCLH QQTCIWRQTLTLECSQSPGRGAPPQTLLVIELPQ PLQTASREILWKKWSMLIRAPALLIT*VPAWST MSVFTLSRMTRKVSLSLIPSSQLFLLPLTCDSP TLVQTPCVSPGLHPHPLI*PTSWCVTHL*KMRKM LQSCQFLLQTMQWS*QISCLVQNM**VSPVSTN NMRAHLLEEDRKQVLIPQLALTFLILLPTLLLC TGLLLEPPSLATGSAIIPSTSVGDLEKIGCPTLG IPSPSPTSLQAQSMWSASLLLMAERKVPY*LAN NQQFLMFRGTWKLLLRPPPAY*SAGMLLLSQ*D ITGSLTERQEEIALSRSSLCLGASLQLPSAALNL ELIIPSLCMLSLAVETAPQAASQFPLITEQKLT NHPRCK*PMFRTTALVSSGCLQVPLLLVTE*PP LPKMDQDQQKLKLQVQIKQK*LLKACSPQWSMWL VSMLRIQAERVSLWFRLQ*PLFLHQLT*SSLRS HPQA*APSGHHPMFSSLDIECG*PPRRRPDQ*K KSTLLLTAHPWLYQDLWWPPNMK*VSMLLRTL*Q ADQLRELSPLWRMSAHQEGLV*QMLLRPPSPLA GEPRLRRSLASKLMPFQPMARLQSREPSSQMSE ATPSQVYNQALTTRSTCTP*MTMLGAPLWSSTPP LPLMHHPTCVSWPPHPIPCWYHGSRHVPGLPAT SSSMRSLGLLPEKWSLGPALVSQRLLLLAWNRE PNIQFMSLP*RIIRRASP*LEGKRQDKKLSLRQP SHGPHSRTLLSTSFHVILLALMKNPYSSGFLEL LPVPL*QASPEVPPTTS*WRH*KTSRGIRFGKR LLPWATLSTKA*TNLRMTRALTPTQFPIMPLEMS GNECLNQALNCCASA*ALEVVISDVIHLDGAMT MV*TTRLERSGTVREKMAR**AAHVLGTEKENS SVTLMRQRVMMMGRHTT*ENSGRRNISVPFAPAH ALEASGAGAVTTAADLGVNPVPKALLASPTTSI LRDTIREQTLMLIAQLSASCL*MYRLTEKIPES KSSFQSRGTSMSLCQDPSKLE*C*QTQLRVLLSF LSPLLWRKFSSFSSTHSFSKHHPGSFLRVFS*M RAAHCLFCFEVFNTAQYFK*SDSKIWFGINRKA YAANQDANVLK*YDQNFK*ESHPNTSAFT*VSGP QYCRNKHDLVTVIF*ISTVLTFSK*S**LPRNI FLLPVIYQFFPVFLYGKNCIENT*YAVDKRNLV *LWWVIIFYTVCAKALLLWKDNCFNKRFTFHNLK FIYLI*DTFGGNNSCEYSFSIQQTFENL*CASL IVDFSTRFSKSVATKTDWFLSLHLFTNGDSFTL SALIDLSGPQYLLKLLVYRSEV**K*SLVALF*P L*FFPSSLHLSFIE*TSVQRDCLQGK*K*LRY* KYLNSIIWRSFILGKPHGMITPI*HVLLWVS*H FWHGLINSQLNSLFTPDL*RSFLFQFNIEETNFG IKFDIQARRSGSHL*SQHFGRLRQVDHLRSGV* DQPGQHGETLSLLKIQMLPGMAVGVFGPGYSEG *GRRMA*TQKAEVAVS*DCAIELQHGGQSKTPSQ KT*INKCDIQNSK*WKWK*LLVKN**FIINKTC KALFKYTNVQ*KKVFQ*TPGKEY*N*IQKDTSS CSFEKKKY*LPFELIYSL*NALTFSYLI*GRF*S LILQGMKLR*GFLSEIQTQPLDFYLLLIFKLYQ PNSHQESCSVCFLKITESTK*R*Y*TTV

Sequence FN1.hAug05

CGGGGCGGGGACAGCCCGGCGGGTCTCTCCTCCCCCGCGCCCCGGGCCTCCAGAGGGGCGGGAGGGGACCGTCCCATATAAGCCCCGGCTCCCGGCGCTC GGACGCCCGCGCCGGCTGTGCTGCACAGGGGGAGGAGAGGGAACCCCAGGCGCGAGCGGGAAGAGGGGACCTGCAGCCACAACTTCTCTGGTCCTCTGCA TCCCTTCTGTCCCTCCACCCGTCCCCTTCCCCACCCTCTGGCCCCCACCTTCTTGGAGGCGACAACCCCCGGGAGGCATTAGAAGGGATTTTTCCCGCAG GTTGCGAAGGGAAGCAAACTTGGTGGCAACTTGCCTCCCGGTGCGGGCGTCTCTCCCCCACCGTCTCAACATGCTTAGGGGTCCGGGGCCCGGGCTGCTG CTGCTGGCCGTCCAGTGCCTGGGGACAGCGGTGCCCTCCACGGGAGCCTCGAAGAGCAAGAGGCAGGCTCAGCAAATGGTTCAGCCCCAGTCCCCGGTGG CTGTCAGTCAAAGCAAGCCCGGTTGTTATGACAATGGAAAACACTATCAGATAAATCAACAGTGGGAGCGGACCTACCTAGGCAATGCGTTGGTTTGTAC TTGTTATGGAGGAAGCCGAGGTTTTAACTGCGAGAGTAAACCTGAAGCTGAAGAGACTTGCTTTGACAAGTACACTGGGAACACTTACCGAGTGGGTGAC ACTTATGAGCGTCCTAAAGACTCCATGATCTGGGACTGTACCTGCATCGGGGCTGGGCGAGGGAGAATAAGCTGTACCATCGCAAACCGCTGCCATGAAG GGGGTCAGTCCTACAAGATTGGTGACACCTGGAGGAGACCACATGAGACTGGTGGTTACATGTTAGAGTGTGTGTGTCTTGGTAATGGAAAAGGAGAATG GACCTGCAAGCCCATAGCTGAGAAGTGTTTTGATCATGCTGCTGGGACTTCCTATGTGGTCGGAGAAACGTGGGAGAAGCCCTACCAAGGCTGGATGATG GTAGATTGTACTTGCCTGGGAGAAGGCAGCGGACGCATCACTTGCACTTCTAGAAATAGATGCAACGATCAGGACACAAGGACATCCTATAGAATTGGAG ACACCTGGAGCAAGAAGGATAATCGAGGAAACCTGCTCCAGTGCATCTGCACAGGCAACGGCCGAGGAGAGTGGAAGTGTGAGAGGCACACCTCTGTGCA GACCACATCGAGCGGATCTGGCCCCTTCACCGATGTTCGTGCAGCTGTTTACCAACCGCAGCCTCACCCCCAGCCTCCTCCCTATGGCCACTGTGTCACA GACAGTGGTGTGGTCTACTCTGTGGGGATGCAGTGGCTGAAGACACAAGGAAATAAGCAAATGCTTTGCACGTGCCTGGGCAACGGAGTCAGCTGCCAAG AGACAGCTGTAACCCAGACTTACGGTGGCAACTCAAATGGAGAGCCATGTGTCTTACCATTCACCTACAATGGCAGGACGTTCTACTCCTGCACCACAGA AGGGCGACAGGACGGACATCTTTGGTGCAGCACAACTTCGAATTATGAGCAGGACCAGAAATACTCTTTCTGCACAGACCACACTGTTTTGGTTCAGACT CGAGGAGGAAATTCCAATGGTGCCTTGTGCCACTTCCCCTTCCTATACAACAACCACAATTACACTGATTGCACTTCTGAGGGCAGAAGAGACAACATGA AGTGGTGTGGGACCACACAGAACTATGATGCCGACCAGAAGTTTGGGTTCTGCCCCATGGCTGCCCACGAGGAAATCTGCACAACCAATGAAGGGGTCAT GTACCGCATTGGAGATCAGTGGGATAAGCAGCATGACATGGGTCACATGATGAGGTGCACGTGTGTTGGGAATGGTCGTGGGGAATGGACATGCATTGCC TACTCGCAGCTTCGAGATCAGTGCATTGTTGATGACATCACTTACAATGTGAACGACACATTCCACAAGCGTCATGAAGAGGGGCACATGCTGAACTGTA CATGCTTCGGTCAGGGTCGGGGCAGGTGGAAGTGTGATCCCGTCGACCAATGCCAGGATTCAGAGACTGGGACGTTTTATCAAATTGGAGATTCATGGGA GAAGTATGTGCATGGTGTCAGATACCAGTGCTACTGCTATGGCCGTGGCATTGGGGAGTGGCATTGCCAACCTTTACAGACCTATCCAAGCTCAAGTGGT CCTGTCGAAGTATTTATCACTGAGACTCCGAGTCAGCCCAACTCCCACCCCATCCAGTGGAATGCACCACAGCCATCTCACATTTCCAAGTACATTCTCA GGTGGAGACCTAAAAATTCTGTAGGCCGTTGGAAGGAAGCTACCATACCAGGCCACTTAAACTCCTACACCATCAAAGGCCTGAAGCCTGGTGTGGTATA CGAGGGCCAGCTCATCAGCATCCAGCAGTACGGCCACCAAGAAGTGACTCGCTTTGACTTCACCACCACCAGCACCAGCACACCTGTGACCAGCAACACC GTGACAGGAGAGACGACTCCCTTTTCTCCTCTTGTGGCCACTTCTGAATCTGTGACCGAAATCACAGCCAGTAGCTTTGTGGTCTCCTGGGTCTCAGCTT CCGACACCGTGTCGGGATTCCGGGTGGAATATGAGCTGAGTGAGGAGGGAGATGAGCCACAGTACCTGGATCTTCCAAGCACAGCCACTTCTGTGAACAT CCCTGACCTGCTTCCTGGCCGAAAATACATTGTAAATGTCTATCAGATATCTGAGGATGGGGAGCAGAGTTTGATCCTGTCTACTTCACAAACAACAGCG CCTGATGCCCCTCCTGACACGACTGTGGACCAAGTTGATGACACCTCAATTGTTGTTCGCTGGAGCAGACCCCAGGCTCCCATCACAGGGTACAGAATAG TCTATTCGCCATCAGTAGAAGGTAGCAGCACAGAACTCAACCTTCCTGAAACTGCAAACTCCGTCACCCTCAGTGACTTGCAACCTGGTGTTCAGTATAA CATCACTATCTATGCTGTGGAAGAAAATCAAGAAAGTACACCTGTTGTCATTCAACAAGAAACCACTGGCACCCCACGCTCAGATACAGTGCCCTCTCCC AGGGACCTGCAGTTTGTGGAAGTGACAGACGTGAAGGTCACCATCATGTGGACACCGCCTGAGAGTGCAGTGACCGGCTACCGTGTGGATGTGATCCCCG TCAACCTGCCTGGCGAGCACGGGCAGAGGCTGCCCATCAGCAGGAACACCTTTGCAGAAGTCACCGGGCTGTCCCCTGGGGTCACCTATTACTTCAAAGT CTTTGCAGTGAGCCATGGGAGGGAGAGCAAGCCTCTGACTGCTCAACAGACAACCAAACTGGATGCTCCCACTAACCTCCAGTTTGTCAATGAAACTGAT TCTACTGTCCTGGTGAGATGGACTCCACCTCGGGCCCAGATAACAGGATACCGACTGACCGTGGGCCTTACCCGAAGAGGACAGCCCAGGCAGTACAATG TGGGTCCCTCTGTCTCCAAGTACCCACTGAGGAATCTGCAGCCTGCATCTGAGTACACCGTATCCCTCGTGGCCATAAAGGGCAACCAAGAGAGCCCCAA AGCCACTGGAGTCTTTACCACACTGCAGCCTGGGAGCTCTATTCCACCTTACAACACCGAGGTGACTGAGACCACCATTGTGATCACATGGACGCCTGCT CCAAGAATTGGTTTTAAGCTGGGTGTACGACCAAGCCAGGGAGGAGAGGCACCACGAGAAGTGACTTCAGACTCAGGAAGCATCGTTGTGTCCGGCTTGA CTCCAGGAGTAGAATACGTCTACACCATCCAAGTCCTGAGAGATGGACAGGAAAGAGATGCGCCAATTGTAAACAAAGTGGTGACACCATTGTCTCCACC AACAAACTTGCATCTGGAGGCAAACCCTGACACTGGAGTGCTCACAGTCTCCTGGGAGAGGAGCACCACCCCAGACATTACTGGTTATAGAATTACCACA ACCCCTACAAACGGCCAGCAGGGAAATTCTTTGGAAGAAGTGGTCCATGCTGATCAGAGCTCCTGCACTTTTGATAACCTGAGTCCCGGCCTGGAGTACA ATGTCAGTGTTTACACTGTCAAGGATGACAAGGAAAGTGTCCCTATCTCTGATACCATCATCCCAGAGGTGCCCCAACTCACTGACCTAAGCTTTGTTGA TATAACCGATTCAAGCATCGGCCTGAGGTGGACCCCGCTAAACTCTTCCACCATTATTGGGTACCGCATCACAGTAGTTGCGGCAGGAGAAGGTATCCCT ATTTTTGAAGATTTTGTGGACTCCTCAGTAGGATACTACACAGTCACAGGGCTGGAGCCGGGCATTGACTATGATATCAGCGTTATCACTCTCATTAATG GCGGCGAGAGTGCCCCTACTACACTGACACAACAAACGGCTGTTCCTCCTCCCACTGACCTGCGATTCACCAACATTGGTCCAGACACCATGCGTGTCAC CTGGGCTCCACCCCCATCCATTGATTTAACCAACTTCCTGGTGCGTTACTCACCTGTGAAAAATGAGGAAGATGTTGCAGAGTTGTCAATTTCTCCTTCA GACAATGCAGTGGTCTTAACAAATCTCCTGCCTGGTACAGAATATGTAGTGAGTGTCTCCAGTGTCTACGAACAACATGAGAGCACACCTCTTAGAGGAA GACAGAAAACAGGTCTTGATTCCCCAACTGGCATTGACTTTTCTGATATTACTGCCAACTCTTTTACTGTGCACTGGATTGCTCCTCGAGCCACCATCAC TGGCTACAGGATCCGCCATCATCCCGAGCACTTCAGTGGGAGACCTCGAGAAGATCGGGTGCCCCACTCTCGGAATTCCATCACCCTCACCAACCTCACT CCAGGCACAGAGTATGTGGTCAGCATCGTTGCTCTTAATGGCAGAGAGGAAAGTCCCTTATTGATTGGCCAACAATCAACAGTTTCTGATGTTCCGAGGG ACCTGGAAGTTGTTGCTGCGACCCCCACCAGCCTACTGATCAGCTGGGATGCTCCTGCTGTCACAGTGAGATATTACAGGATCACTTACGGAGAGACAGG AGGAAATAGCCCTGTCCAGGAGTTCACTGTGCCTGGGAGCAAGTCTACAGCTACCATCAGCGGCCTTAAACCTGGAGTTGATTATACCATCACTGTGTAT GCTGTCACTGGCCGTGGAGACAGCCCCGCAAGCAGCAAGCCAATTTCCATTAATTACCGAACAGAAATTGACAAACCATCCCAGATGCAAGTGACCGATG TTCAGGACAACAGCATTAGTGTCAAGTGGCTGCCTTCAAGTTCCCCTGTTACTGGTTACAGAGTAACCACCACTCCCAAAAATGGACCAGGACCAACAAA AACTAAAACTGCAGGTCCAGATCAAACAGAAATGACTATTGAAGGCTTGCAGCCCACAGTGGAGTATGTGGTTAGTGTCTATGCTCAGAATCCAAGCGGA GAGAGTCAGCCTCTGGTTCAGACTGCAGTAACCACTATTCCTGCACCAACTGACCTGAAGTTCACTCAGGTCACACCCACAAGCCTGAGCGCCCAGTGGA CACCACCCAATGTTCAGCTCACTGGATATCGAGTGCGGGTGACCCCCAAGGAGAAGACCGGACCAATGAAAGAAATCAACCTTGCTCCTGACAGCTCATC CGTGGTTGTATCAGGACTTATGGTGGCCACCAAATATGAAGTGAGTGTCTATGCTCTTAAGGACACTTTGACAAGCAGACCAGCTCAGGGAGTTGTCACC ACTCTGGAGAATGTCAGCCCACCAAGAAGGGCTCGTGTGACAGATGCTACTGAGACCACCATCACCATTAGCTGGAGAACCAAGACTGAGACGATCACTG GCTTCCAAGTTGATGCCGTTCCAGCCAATGGCCAGACTCCAATCCAGAGAACCATCAAGCCAGATGTCAGAAGCTACACCATCACAGGTTTACAACCAGG CACTGACTACAAGATCTACCTGTACACCTTGAATGACAATGCTCGGAGCTCCCCTGTGGTCATCGACGCCTCCACTGCCATTGATGCACCATCCAACCTG CGTTTCCTGGCCACCACACCCAATTCCTTGCTGGTATCATGGCAGCCGCCACGTGCCAGGATTACCGGCTACATCATCAAGTATGAGAAGCCTGGGTCTC CTCCCAGAGAAGTGGTCCCTCGGCCCCGCCCTGGTGTCACAGAGGCTACTATTACTGGCCTGGAACCGGGAACCGAATATACAATTTATGTCATTGCCCT GAAGAATAATCAGAAGAGCGAGCCCCTGATTGGAAGGAAAAAGACAGGACAAGAAGCTCTCTCTCAGACAACCATCTCATGGGCCCCATTCCAGGACACT TCTGAGTACATCATTTCATGTCATCCTGTTGGCACTGATGAAGAACCCTTACAGTTCAGGGTTCCTGGAACTTCTACCAGTGCCACTCTGACAGGCCTCA CCAGAGGTGCCACCTACAACGTCATAGTGGAGGCACTGAAAGACCAGCAGAGGCATAAGGTTCGGGAAGAGGTTGTTACCGTGGGCAACTCTGTCAACGA AGGCTTGAACCAACCTACGGATGACTCGTGCTTTGACCCCTACACAGTTTCCCATTATGCCGTTGGAGATGAGTGGGAACGAATGTCTGAATCAGGCTTT AAACTGTTGTGCCAGTGCTTAGGCTTTGGAAGTGGTCATTTCAGATGTGATTCATCTAGATGGTGCCATGACAATGGTGTGAACTACAAGATTGGAGAGA AGTGGGACCGTCAGGGAGAAAATGGCCAGATGATGAGCTGCACATGTCTTGGGAACGGAAAAGGAGAATTCAAGTGTGACCCTCATGAGGCAACGTGTTA TGATGATGGGAAGACATACCACGTAGGAGAACAGTGGCAGAAGGAATATCTCGGTGCCATTTGCTCCTGCACATGCTTTGGAGGCCAGCGGGGCTGGCGC TGTGACAACTGCCGCAGACCTGGGGGTGAACCCAGTCCCGAAGGCACTACTGGCCAGTCCTACAACCAGTATTCTCAGAGATACCATCAGAGAACAAACA CTAATGTTAATTGCCCAATTGAGTGCTTCATGCCTTTAGATGTACAGGCTGACAGAGAAGATTCCCGAGAGTAAATCATCTTTCCAATCCAGAGGAACAA GCATGTCTCTCTGCCAAGATCCATCTAAACTGGAGTGATGTTAGCAGACCCAGCTTAGAGTTCTTCTTTCTTTCTTAAGCCCTTTGCTCTGGAGGAAGTT CTCCAGCTTCAGCTCAACTCACAGCTTCTCCAAGCATCACCCTGGGAGTTTCCTGAGGGTTTTCTCATAAATGAGGGCTGCACATTGCCTGTTCTGCTTC GAAGTATTCAATACCGCTCAGTATTTTAAATGAAGTGATTCTAAGATTTGGTTTGGGATCAATAGGAAAGCATATGCAGCCAACCAAGATGCAAATGTTT TGAAATGATATGACCAAAATTTTAAGTAGGAAAGTCACCCAAACACTTCTGCTTTCACTTAAGTGTCTGGCCCGCAATACTGTAGGAACAAGCATGATCT TGTTACTGTGATATTTTAAATATCCACAGTACTCACTTTTTCCAAATGATCCTAGTAATTGCCTAGAAATATCTTTCTCTTACCTGTTATTTATCAATTT TTCCCAGTATTTTTATACGGAAAAAATTGTATTGAAAACACTTAGTATGCAGTTGATAAGAGGAATTTGGTATAATTATGGTGGGTGATTATTTTTTATA CTGTATGTGCCAAAGCTTTACTACTGTGGAAAGACAACTGTTTTAATAAAAGATTTACATTCCACAACTTGAAGTTCATCTATTTGATATAAGACACCTT CGGGGGAAATAATTCCTGTGAATATTCTTTTTCAATTCAGCAAACATTTGAAAATCTATGATGTGCAAGTCTAATTGTTGATTTCAGTACAAGATTTTCT AAATCAGTTGCTACAAAAACTGATTGGTTTTTGTCACTTCATCTCTTCACTAATGGAGATAGCTTTACACTTTCTGCTTTAATAGATTTAAGTGGACCCC AATATTTATTAAAATTGCTAGTTTACCGTTCAGAAGTATAATAGAAATAATCTTTAGTTGCTCTTTTCTAACCATTGTAATTCTTCCCTTCTTCCCTCCA CCTTTCCTTCATTGAATAAACCTCTGTTCAAAGAGATTGCCTGCAAGGGAAATAAAAATGACTAAGATATTAAAAGTATTTGAATAGTATAATATGGAGG AGTTTTATCTTAGGGAAACCCCATGGTATGATAACCCCCATCTAACATGTCTTACTTTGGGTCAGCTGACACTTTTGGCATGGCTTGATAAACTCCCAGC TAAACAGTTTGTTTACTCCTGATCTGTAAAGGTCATTTCTTTTTCAATTTAACATTGAGGAAACAAACTTTGGGATTAAATTTGACATTCAGGCCAGGCG CAGTGGCTCACACCTCTAATCCCAGCACTTTGGGAGGCTGAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACC TTGTCTCTATTAAAAATACAAATGTTACCAGGCATGGCAGTGGGCGTCTTTGGTCCCGGCTACTCAGAAGGCTGAGGTAGGAGAATGGCTTGAACCCAGA AGGCGGAGGTTGCAGTGAGCTGAGATTGTGCCATTGAACTCCAGCATGGGGGACAGAGCAAGACTCCATCCCAAAAAACATAAATAAATAAATGTGACAT TCAGAATAGTAAATAGTGGAAATGGAAATAATTATTAGTAAAAAATTAGTAGTTCATAATAAACAAGACATGCAAAGCACTTTTTAAATATACTAATGTA CAATGAAAGAAGGTATTTCAATAAACACCTGGCAAAGAATATTAAAACTAAATACAGAAAGATACTTCCTCATGTTCATTTGAAAAAAAAAAATACTAAC TCCCATTTGAATTGATTTACAGTTTATAAAATGCTTTGACATTTAGCTATCTCATTTAGGGGAGGTTTTAGAGCTTAATTTTACAGGGCATGAAGCTCAG ATGAGGTTTCCTTAGCGAAATACAGACCCAGCCCCTGGACTTCTATTTATTACTGATCTTTAAGCTTTATCAGCCCAATAGTCACCAAGAGAGCTGCTCT GTATGTTTTTTAAAAATCACAGAAAGTACAAAATAAAGGTGATATTAAACGACTGTC

FN1.u.f.55 (forward primer)
FN1.u.r.66 (reverse primer)
Single exon skipping

Frame 0

RGGDSPAGLSSPAPRASRGAGGDRPI*APAPGA RTPAPAVLHRGRRGNPRREREEGTCSHNFSGPLH PFCPSTRPLPHPLAPTFLEATTPGRH*KGFFPQ VAKGSKLGGNLPPGAGVSPPPSQHA*GSGARAA AAGRPVPGDSGALHGSLEEQEAGSANGSAPVPGG CQSKQARLL*QWKTLSDKSTVGADLPRQCVGLY LLWRKPRF*LRE*T*S*RDLL*QVHWEHLPSG* HL*AS*RLHDLGLYLHRGWARENKLYHRKPLP*R GSVLQDW*HLEETT*DWWLHVRVCVSW*WKRRM DLQAHS*EVF*SCCWDFLCGRRNVGEALPRLDD GRLYLPGRRQRTHHLHF*K*MQRSGHKDIL*NWR HLEQEG*SRKPAPVHLHRQRPRRVEV*EAHLCA DHIERIWPLHRCSCSCLPTAASPPASSLWPLCH RQWCGLLCGDAVAEDTRK*ANALHVPGQRSQLPR DSCNPDLRWQLKWRAMCLTIHLQWQDVLLLHHR RATGRTSLVQHNFEL*AGPEILFLHRPHCFGSD SRRKFQWCLVPLPLPIQQPQLH*LHF*GQKRQHE VVWDHTEL*CRPEVWVLPHGCPRGNLHNQ*RGH VPHWRSVG*AA*HGSHDEVHVCWEWSWGMDMHC LLAASRSVHC**HHLQCERHIPQAS*RGAHAELY MLRSGSGQVEV*SRRPMPGFRDWDVLSNWRFMG EVCAWCQIPVLLLWPWHWGVALPTFTDLSKLKW SCRSIYH*DSESAQLPPHPVECTTAISHFQVHSQ VET*KFCRPLEGSYHTRPLKLLHHQRPEAWCGI RGPAHQHPAVRPPRSDSL*LHHHQHQHTCDQQH RDRRDDSLFSSCGHF*ICDRNHSQ*LCGLLGLSF RHRVGIPGGI*AE*GGR*ATVPGSSKHSHFCEH P*PASWPKIHCKCLSDI*GWGAEFDPVYFTNNS A*CPS*HDCGPS**HLNCCSLEQTPGSHHRVQNS LFAISRR*QHRTQPS*NCKLRHPQ*LATWCSV* HHYLCCGRKSRKYTCCHSTRNHWHPTLRYSALS QGPAVCGSDRREGHHHVDTA*ECSDRLPCGCDPR QPAWRARAEAAHQQEHLCRSHRAVPWGHLLLQS LCSEPWEGEQASDCSTDNQTGCSH*PPVCQ*N* FYCPGEMDSTSGPDNRIPTDRGPYPKRTAQAVQC GSLCLQVPTEESAACI*VHRIPRGHKGQPREPQ SHWSLYHTAAWELYSTLQHRGD*DHHCDHMDAC SKNWF*AGCTTKPGRRGTTRSDFRLRKHRCVRLD SRSRIRLHHPSPERWTGKRCANCKQSGDTIVST NKLASGGKP*HWSAHSLLGEEHHPRHYWL*NYH NPYKRPAGKFFGRSGPC*SELLHF**PESRPGVQ CQCLHCQG*QGKCPYL*YHHPRGAPTH*PKLC* YNRFKHRPEVDPAKLFHHYWVPHHSSCGRRRYP YF*RFCGLLSRILHSHRAGAGH*L*YQRYHSH*W RRECPYYTDTTNGCSSSH*PAIHQHWSRHHACH LGSTPIH*FNQLPGALLTCEK*GRCCRVVNFSF RQCSGLNKSPAWYRICSECLQCLRTT*EHTS*RK TENRS*FPNWH*LF*YYCQLFYCALDCSSSHHH WLQDPPSSRALQWETSRRSGAPLSEFHHPHQPH SRHRVCGQHRCS*WQRGKSLIDWPTINSF*CSEG PGSCCCDPHQPTDQLGCSCCHSEILQDHLRRDR RK*PCPGVHCAWEQVYSYHQRP*TWS*LYHHCV CCHWPWRQPRKQQANFH*LPNRN*QTIPDASDRC SGQQH*CQVAAFKFPCYWLQSNHHSQKWTRTNK N*NCRSRSNRNDY*RLAAHSGVCG*CLCSESKR RESASGSDCSNHYSCTN*PEVHSGHTHKPERPVD TTQCSAHWISSAGDPQGEDRTNERNQPCS*QLI RGCIRTYGGHQI*SECLCS*GHFDKQTSSGSCH HSGECQPTKKGSCDRCY*DHHHH*LENQD*DDHW LPS*CRSSQWPDSNPENHQARCQKLHHHRFTTR H*LQDLPVHLE*QCSELPCGHRRLHCH*CTIQP AFPGHHTQFLAGIMAAATCQDYRLHHQV*EAWVS SQRSGPSAPPWCHRGYYYWPGTGNRIYNLCHCP EE*SEERAPDWKEKDRTRSSLSDNHLMGPIPGH F*VHHFMSSCWH**RTLTVQGSWNFYQCHSDRPH QRCHLQRHSGGTERPAEA*GSGRGCYRGQLCQR RLEPTYG*LVL*PLHSFPLCRWR*VGTNV*IRL *TVVPVLRLWKWSFQM*FI*MVP*QWCELQDWRE VGPSGRKWPDDELHMSWERKRRIQV*PS*GNVL **WEDIPRRRTVAEGISRCHLLLHMLWRPAGLA L*QLPQTWG*TQSRRHYWPVLQPVFSEIPSENKH *C*LPN*VLHAFRCTG*QRRFPRVNHLSNPEEQ ACLSAKIHLNWSDVSRPSLEFFFLS*ALCSGGS SPASAQLTASPSITLGVS*GFSHK*GLHIACSAS KYSIPLSILNEVILRFGLGSIGKHMQPTKMQMF *NDMTKILSRKVTQTLLLSLKCLARNTVGTSMI LLL*YFKYPQYSLFPNDPSNCLEISFSYLLFINF SQYFYTEKIVLKTLSMQLIRGIWYNYGG*LFFI LYVPKLYYCGKTTVLIKDLHSTT*SSSI*YKTP SGEIIPVNILFQFSKHLKIYDVQV*LLISVQDFL NQLLQKLIGFCHFISSLMEIALHFLL**I*VDP NIY*NC*FTVQKYNRNNL*LLFSNHCNSSLLPS TFPSLNKPLFKEIACKGNKND*DIKSI*IV*YGG VLS*GNPMV**PPSNMSYFGSADTFGMA**TPS *TVCLLLICKGHFFFNLTLRKQTLGLNLTFRPG AVAHTSNPSTLGG*GRWIT*GQEFETSLANMVKP CLY*KYKCYQAWQWASLVPATQKAEVGEWLEPR RRRLQ*AEIVPLNSSMGDRARLHPKKHK*INVT FRIVNSGNGNNY**KISSS**TRHAKHFLNILMY NERRYFNKHLAKNIKTKYRKILPHVHLKKKNTN SHLN*FTVYKML*HLAISFRGGFRA*FYRA*SS DEVSLAKYRPSPWTSIYY*SLSFISPIVTKRAAL YVF*KSQKVQNKGDIKRL

Frame 1

GAGTARRVSPPPRPGPPEGREGTVPYKPRLPAL GRPRRLCCTGGGEGTPGASGKRGPAATTSLVLC IPSVPPPVPFPTLWPPPSWRRQPPGGIRRDFSRR LRREANLVATCLPVRASLPHRLNMLRGPGPGLL LLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPV AVSQSKPGCYDNGKHYQINQQWERTYLGNALVCT CYGGSRGFNCESKPEAEETCFDKYTGNTYRVGD TYERPKDSMIWDCTCIGAGRGRISCTIANRCHE GGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEW TCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMM VDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIG DTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQ TTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVT DSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQ ETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTE GRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQT RGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNM KWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVM YRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIA YSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNC TCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWE KYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSG PVEVFITETPSQPNSHPIQWNAPQPSHISKYIL RWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVY EGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNT VTGETTPFSPLVATSESVTEITASSFVVSWVSA SDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNI PDLLPGRKYIVNVYQISEDGEQSLILSTSQTTA PDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRI VYSPSVEGSSTELNLPETANSVTLSDLQPGVQYN ITIYAVEENQESTPVVIQQETTGTPRSDTVPSP RDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIP VNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKV FAVSHGRESKPLTAQQTTKLDAPTNLQFVNETD STVLVRWTPPRAQITGYRLTVGLTRRGQPRQYN VGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPK ATGVFTTLQPGSSIPPYNTEVTETTIVITWTPA PRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGL TPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPP TNLHLEANPDTGVLTVSWERSTTPDITGYRITT TPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEY NVSVYTVKDDKESVPISDTIIPEVPQLTDLSFVD ITDSSIGLRWTPLNSSTIIGYRITVVAAGEGIP IFEDFVDSSVGYYTVTGLEPGIDYDISVITLIN GGESAPTTLTQQTAVPPPTDLRFTNIGPDTMRVT WAPPPSIDLTNFLVRYSPVKNEEDVAELSISPS DNAVVLTNLLPGTEYVVSVSSVYEQHESTPLRG RQKTGLDSPTGIDFSDITANSFTVHWIAPRATIT GYRIRHHPEHFSGRPREDRVPHSRNSITLTNLT PGTEYVVSIVALNGREESPLLIGQQSTVSDVPR DLEVVAATPTSLLISWDAPAVTVRYYRITYGETG GNSPVQEFTVPGSKSTATISGLKPGVDYTITVY AVTGRGDSPASSKPISINYRTEIDKPSQMQVTD VQDNSISVKWLPSSSPVTGYRVTTTPKNGPGPTK TKTAGPDQTEMTIEGLQPTVEYVVSVYAQNPSG ESQPLVQTAVTTIPAPTDLKFTQVTPTSLSAQW TPPNVQLTGYRVRVTPKEKTGPMKEINLAPDSSS VVVSGLMVATKYEVSVYALKDTLTSRPAQGVVT TLENVSPPRRARVTDATETTITISWRTKTETIT GFQVDAVPANGQTPIQRTIKPDVRSYTITGLQPG TDYKIYLYTLNDNARSSPVVIDASTAIDAPSNL RFLATTPNSLLVSWQPPRARITGYIIKYEKPGS PPREVVPRPRPGVTEATITGLEPGTEYTIYVIAL KNNQKSEPLIGRKKTGQEALSQTTISWAPFQDT SEYIISCHPVGTDEEPLQFRVPGTSTSATLTGL TRGATYNVIVEALKDQQRHKVREEVVTVGNSVNE GLNQPTDDSCFDPYTVSHYAVGDEWERMSESGF KLLCQCLGFGSGHFRCDSSRWCHDNGVNYKIGE KWDRQGENGQMMSCTCLGNGKGEFKCDPHEATCY DDGKTYHVGEQWQKEYLGAICSCTCFGGQRGWR CDNCRRPGGEPSPEGTTGQSYNQYSQRYHQRTN TNVNCPIECFMPLDVQADREDSRE*IIFPIQRNK HVSLPRSI*TGVMLADPA*SSSFFLKPFALEEV LQLQLNSQLLQASPWEFPEGFLINEGCTLPVLL RSIQYRSVF*MK*F*DLVWDQ*ESICSQPRCKCF EMI*PKF*VGKSPKHFCFHLSVWPAIL*EQA*S CYCDILNIHSTHFFQMILVIA*KYLSLTCYLSI FPSIFIRKKLY*KHLVCS**EEFGIIMVGDYFLY CMCQSFTTVERQLF**KIYIPQLEVHLFDIRHL RGK*FL*IFFFNSANI*KSMMCKSNC*FQYKIF *ISCYKN*LVFVTSSLH*WR*LYTFCFNRFKWTP IFIKIASLPFRSIIEIIFSCSFLTIVILPFFPP PFLH*INLCSKRLPAREIKMTKILKVFE*YNME EFYLRETPWYDNPHLTCLTLGQLTLLAWLDKLPA KQFVYS*SVKVISFSI*H*GNKLWD*I*HSGQA QWLTPLIPALWEAEAGGSPEVRSLRPAWPTW*N LVSIKNTNVTRHGSGRLWSRLLRRLR*ENGLNPE GGGCSELRLCH*TPAWGTEQDSIPKNINK*M*H SE**IVEMEIIISKKLVVHNKQDMQSTF*IY*C TMKEGISINTWQRILKLNTERYFLMFI*KKKILT PI*IDLQFIKCFDI*LSHLGEVLELNFTGHEAQ MRFP*RNTDPAPGLLFITDL*ALSAQ*SPRELL CMFFKNHRKYKIKVILNDC

Frame 2

GRGQPGGSLLPRAPGLQRGGRGPSHISPGSRRS DARAGCAAQGEEREPQARAGRGDLQPQLLWSSA SLLSLHPSPSPPSGPHLLGGDNPREALEGIFPA GCEGKQTWWQLASRCGRLSPTVSTCLGVRGPGCC CWPSSAWGQRCPPREPRRARGRLSKWFSPSPRW LSVKASPVVMTMENTIR*INSGSGPT*AMRWFV LVMEEAEVLTARVNLKLKRLALTSTLGTLTEWVT LMSVLKTP*SGTVPASGLGEGE*AVPSQTAAMK GVSPTRLVTPGGDHMRLVVTC*SVCVLVMEKEN GPASP*LRSVLIMLLGLPMWSEKRGRSPTKAG*W *IVLAWEKAADASLALLEIDATIRTQGHPIELE TPGARRIIEETCSSASAQATAEESGSVRGTPLC RPHRADLAPSPMFVQLFTNRSLTPSLLPMATVSQ TVVWSTLWGCSG*RHKEISKCFARAWATESAAK RQL*PRLTVATQMESHVSYHSPTMAGRSTPAPQ KGDRTDIFGAAQLRIMSRTRNTLSAQTTLFWFRL EEEIPMVPCATSPSYTTTTITLIALLRAEETT* SGVGPHRTMMPTRSLGSAPWLPTRKSAQPMKGS CTALEISGISSMTWVT**GARVLGMVVGNGHALP TRSFEISALLMTSLTM*TTHSTSVMKRGTC*TV HASVRVGAGGSVIPSTNARIQRLGRFIKLEIHG RSMCMVSDTSATAMAVALGSGIANLYRPIQAQVV LSKYLSLRLRVSPTPTPSSGMHHSHLTFPSTFS GGDLKIL*AVGRKLPYQAT*TPTPSKA*SLVWY TRASSSASSSTATKK*LALTSPPPAPAHL*PATP *QERRLPFLLLWPLLNL*PKSQPVALWSPGSQL PTPCRDSGWNMS*VRREMSHSTWIFQAQPLL*T SLTCFLAENTL*MSIRYLRMGSRV*SCLLHKQQR LMPLLTRLWTKLMTPQLLFAGADPRLPSQGTE* SIRHQ*KVAAQNSTFLKLQTPSPSVTCNLVFSI TSLSMLWKKIKKVHLLSFNKKPLAPHAQIQCPLP GTCSLWK*QT*RSPSCGHRLRVQ*PATVWM*SP STCLASTGRGCPSAGTPLQKSPGCPLGSPITSK SLQ*AMGGRASL*LLNRQPNWMLPLTSSLSMKLI LLSW*DGLHLGPR*QDTD*PWALPEEDSPGSTM WVPLSPSTH*GICSLHLSTPYPSWP*RATKRAP KPLESLPHCSLGALFHLTTPR*LRPPL*SHGRLL QELVLSWVYDQAREERHHEK*LQTQEASLCPA* LQE*NTSTPSKS*EMDRKEMRQL*TKW*HHCLH QQTCIWRQTLTLECSQSPGRGAPPQTLLVIELPQ PLQTASREILWKKWSMLIRAPALLIT*VPAWST MSVFTLSRMTRKVSLSLIPSSQRCPNSLT*ALL I*PIQASA*GGPR*TLPPLLGTASQ*LRQEKVSL FLKILWTPQ*DTTQSQGWSRALTMISALSLSLM AARVPLLH*HNKRLFLLPLTCDSPTLVQTPCVS PGLHPHPLI*PTSWCVTHL*KMRKMLQSCQFLLQ TMQWS*QISCLVQNM**VSPVSTNNMRAHLLEE DRKQVLIPQLALTFLILLPTLLLCTGLLLEPPS LATGSAIIPSTSVGDLEKIGCPTLGIPSPSPTSL QAQSMWSASLLLMAERKVPY*LANNQQFLMFRG TWKLLLRPPPAY*SAGMLLLSQ*DITGSLTERQ EEIALSRSSLCLGASLQLPSAALNLELIIPSLCM LSLAVETAPQAASQFPLITEQKLTNHPRCK*PM FRTTALVSSGCLQVPLLLVTE*PPLPKMDQDQQ KLKLQVQIKQK*LLKACSPQWSMWLVSMLRIQAE RVSLWFRLQ*PLFLHQLT*SSLRSHPQA*APSG HHPMFSSLDIECG*PPRRRPDQ*KKSTLLLTAH PWLYQDLWWPPNMK*VSMLLRTL*QADQLRELSP LWRMSAHQEGLV*QMLLRPPSPLAGEPRLRRSL ASKLMPFQPMARLQSREPSSQMSEATPSQVYNQ ALTTRSTCTP*MTMLGAPLWSSTPPLPLMHHPTC VSWPPHPIPCWYHGSRHVPGLPATSSSMRSLGL LPEKWSLGPALVSQRLLLLAWNREPNIQFMSLP *RIIRRASP*LEGKRQDKKLSLRQPSHGPHSRTL LSTSFHVILLALMKNPYSSGFLELLPVPL*QAS PEVPPTTS*WRH*KTSRGIRFGKRLLPWATLST KA*TNLRMTRALTPTQFPIMPLEMSGNECLNQAL NCCASA*ALEVVISDVIHLDGAMTMV*TTRLER SGTVREKMAR**AAHVLGTEKENSSVTLMRQRV MMMGRHTT*ENSGRRNISVPFAPAHALEASGAGA VTTAADLGVNPVPKALLASPTTSILRDTIREQT LMLIAQLSASCL*MYRLTEKIPESKSSFQSRGT SMSLCQDPSKLE*C*QTQLRVLLSFLSPLLWRKF SSFSSTHSFSKHHPGSFLRVFS*MRAAHCLFCF EVFNTAQYFK*SDSKIWFGINRKAYAANQDANV LK*YDQNFK*ESHPNTSAFT*VSGPQYCRNKHDL VTVIF*ISTVLTFSK*S**LPRNIFLLPVIYQF FPVFLYGKNCIENT*YAVDKRNLV*LWWVIIFY TVCAKALLLWKDNCFNKRFTFHNLKFIYLI*DTF GGNNSCEYSFSIQQTFENL*CASLIVDFSTRFS KSVATKTDWFLSLHLFTNGDSFTLSALIDLSGP QYLLKLLVYRSEV**K*SLVALF*PL*FFPSSLH LSFIE*TSVQRDCLQGK*K*LRY*KYLNSIIWR SFILGKPHGMITPI*HVLLWVS*HFWHGLINSQ LNSLFTPDL*RSFLFQFNIEETNFGIKFDIQARR SGSHL*SQHFGRLRQVDHLRSGV*DQPGQHGET LSLLKIQMLPGMAVGVFGPGYSEG*GRRMA*TQ KAEVAVS*DCAIELQHGGQSKTPSQKT*INKCDI QNSK*WKWK*LLVKN**FIINKTCKALFKYTNV Q*KKVFQ*TPGKEY*N*IQKDTSSCSFEKKKY* LPFELIYSL*NALTFSYLI*GRF*SLILQGMKLR *GFLSEIQTQPLDFYLLLIFKLYQPNSHQESCS VCFLKITESTK*R*Y*TTV

Sequence FN1.gAug05

CGGGGCGGGGACAGCCCGGCGGGTCTCTCCTCCCCCGCGCCCCGGGCCTCCAGAGGGGCGGGAGGGGACCGTCCCATATAAGCCCCGGCTCCCGGCGCTC GGACGCCCGCGCCGGCTGTGCTGCACAGGGGGAGGAGAGGGAACCCCAGGCGCGAGCGGGAAGAGGGGACCTGCAGCCACAACTTCTCTGGTCCTCTGCA TCCCTTCTGTCCCTCCACCCGTCCCCTTCCCCACCCTCTGGCCCCCACCTTCTTGGAGGCGACAACCCCCGGGAGGCATTAGAAGGGATTTTTCCCGCAG GTTGCGAAGGGAAGCAAACTTGGTGGCAACTTGCCTCCCGGTGCGGGCGTCTCTCCCCCACCGTCTCAACATGCTTAGGGGTCCGGGGCCCGGGCTGCTG CTGCTGGCCGTCCAGTGCCTGGGGACAGCGGTGCCCTCCACGGGAGCCTCGAAGAGCAAGAGGCAGGCTCAGCAAATGGTTCAGCCCCAGTCCCCGGTGG CTGTCAGTCAAAGCAAGCCCGGTTGTTATGACAATGGAAAACACTATCAGATAAATCAACAGTGGGAGCGGACCTACCTAGGCAATGCGTTGGTTTGTAC TTGTTATGGAGGAAGCCGAGGTTTTAACTGCGAGAGTAAACCTGAAGCTGAAGAGACTTGCTTTGACAAGTACACTGGGAACACTTACCGAGTGGGTGAC ACTTATGAGCGTCCTAAAGACTCCATGATCTGGGACTGTACCTGCATCGGGGCTGGGCGAGGGAGAATAAGCTGTACCATCGCAAACCGCTGCCATGAAG GGGGTCAGTCCTACAAGATTGGTGACACCTGGAGGAGACCACATGAGACTGGTGGTTACATGTTAGAGTGTGTGTGTCTTGGTAATGGAAAAGGAGAATG GACCTGCAAGCCCATAGCTGAGAAGTGTTTTGATCATGCTGCTGGGACTTCCTATGTGGTCGGAGAAACGTGGGAGAAGCCCTACCAAGGCTGGATGATG GTAGATTGTACTTGCCTGGGAGAAGGCAGCGGACGCATCACTTGCACTTCTAGAAATAGATGCAACGATCAGGACACAAGGACATCCTATAGAATTGGAG ACACCTGGAGCAAGAAGGATAATCGAGGAAACCTGCTCCAGTGCATCTGCACAGGCAACGGCCGAGGAGAGTGGAAGTGTGAGAGGCACACCTCTGTGCA GACCACATCGAGCGGATCTGGCCCCTTCACCGATGTTCGTGCAGCTGTTTACCAACCGCAGCCTCACCCCCAGCCTCCTCCCTATGGCCACTGTGTCACA GACAGTGGTGTGGTCTACTCTGTGGGGATGCAGTGGCTGAAGACACAAGGAAATAAGCAAATGCTTTGCACGTGCCTGGGCAACGGAGTCAGCTGCCAAG AGACAGCTGTAACCCAGACTTACGGTGGCAACTCAAATGGAGAGCCATGTGTCTTACCATTCACCTACAATGGCAGGACGTTCTACTCCTGCACCACAGA AGGGCGACAGGACGGACATCTTTGGTGCAGCACAACTTCGAATTATGAGCAGGACCAGAAATACTCTTTCTGCACAGACCACACTGTTTTGGTTCAGACT CGAGGAGGAAATTCCAATGGTGCCTTGTGCCACTTCCCCTTCCTATACAACAACCACAATTACACTGATTGCACTTCTGAGGGCAGAAGAGACAACATGA AGTGGTGTGGGACCACACAGAACTATGATGCCGACCAGAAGTTTGGGTTCTGCCCCATGGCTGCCCACGAGGAAATCTGCACAACCAATGAAGGGGTCAT GTACCGCATTGGAGATCAGTGGGATAAGCAGCATGACATGGGTCACATGATGAGGTGCACGTGTGTTGGGAATGGTCGTGGGGAATGGACATGCATTGCC TACTCGCAGCTTCGAGATCAGTGCATTGTTGATGACATCACTTACAATGTGAACGACACATTCCACAAGCGTCATGAAGAGGGGCACATGCTGAACTGTA CATGCTTCGGTCAGGGTCGGGGCAGGTGGAAGTGTGATCCCGTCGACCAATGCCAGGATTCAGAGACTGGGACGTTTTATCAAATTGGAGATTCATGGGA GAAGTATGTGCATGGTGTCAGATACCAGTGCTACTGCTATGGCCGTGGCATTGGGGAGTGGCATTGCCAACCTTTACAGACCTATCCAAGCTCAAGTGGT CCTGTCGAAGTATTTATCACTGAGACTCCGAGTCAGCCCAACTCCCACCCCATCCAGTGGAATGCACCACAGCCATCTCACATTTCCAAGTACATTCTCA GGTGGAGACCTAAAAATTCTGTAGGCCGTTGGAAGGAAGCTACCATACCAGGCCACTTAAACTCCTACACCATCAAAGGCCTGAAGCCTGGTGTGGTATA CGAGGGCCAGCTCATCAGCATCCAGCAGTACGGCCACCAAGAAGTGACTCGCTTTGACTTCACCACCACCAGCACCAGCACACCTGTGACCAGCAACACC GTGACAGGAGAGACGACTCCCTTTTCTCCTCTTGTGGCCACTTCTGAATCTGTGACCGAAATCACAGCCAGTAGCTTTGTGGTCTCCTGGGTCTCAGCTT CCGACACCGTGTCGGGATTCCGGGTGGAATATGAGCTGAGTGAGGAGGGAGATGAGCCACAGTACCTGGATCTTCCAAGCACAGCCACTTCTGTGAACAT CCCTGACCTGCTTCCTGGCCGAAAATACATTGTAAATGTCTATCAGATATCTGAGGATGGGGAGCAGAGTTTGATCCTGTCTACTTCACAAACAACAGCG CCTGATGCCCCTCCTGACACGACTGTGGACCAAGTTGATGACACCTCAATTGTTGTTCGCTGGAGCAGACCCCAGGCTCCCATCACAGGGTACAGAATAG TCTATTCGCCATCAGTAGAAGGTAGCAGCACAGAACTCAACCTTCCTGAAACTGCAAACTCCGTCACCCTCAGTGACTTGCAACCTGGTGTTCAGTATAA CATCACTATCTATGCTGTGGAAGAAAATCAAGAAAGTACACCTGTTGTCATTCAACAAGAAACCACTGGCACCCCACGCTCAGATACAGTGCCCTCTCCC AGGGACCTGCAGTTTGTGGAAGTGACAGACGTGAAGGTCACCATCATGTGGACACCGCCTGAGAGTGCAGTGACCGGCTACCGTGTGGATGTGATCCCCG TCAACCTGCCTGGCGAGCACGGGCAGAGGCTGCCCATCAGCAGGAACACCTTTGCAGAAGTCACCGGGCTGTCCCCTGGGGTCACCTATTACTTCAAAGT CTTTGCAGTGAGCCATGGGAGGGAGAGCAAGCCTCTGACTGCTCAACAGACAACCAAACTGGATGCTCCCACTAACCTCCAGTTTGTCAATGAAACTGAT TCTACTGTCCTGGTGAGATGGACTCCACCTCGGGCCCAGATAACAGGATACCGACTGACCGTGGGCCTTACCCGAAGAGGACAGCCCAGGCAGTACAATG TGGGTCCCTCTGTCTCCAAGTACCCACTGAGGAATCTGCAGCCTGCATCTGAGTACACCGTATCCCTCGTGGCCATAAAGGGCAACCAAGAGAGCCCCAA AGCCACTGGAGTCTTTACCACACTGCAGCCTGGGAGCTCTATTCCACCTTACAACACCGAGGTGACTGAGACCACCATTGTGATCACATGGACGCCTGCT CCAAGAATTGGTTTTAAGCTGGGTGTACGACCAAGCCAGGGAGGAGAGGCACCACGAGAAGTGACTTCAGACTCAGGAAGCATCGTTGTGTCCGGCTTGA CTCCAGGAGTAGAATACGTCTACACCATCCAAGTCCTGAGAGATGGACAGGAAAGAGATGCGCCAATTGTAAACAAAGTGGTGACACCATTGTCTCCACC AACAAACTTGCATCTGGAGGCAAACCCTGACACTGGAGTGCTCACAGTCTCCTGGGAGAGGAGCACCACCCCAGACATTACTGGTTATAGAATTACCACA ACCCCTACAAACGGCCAGCAGGGAAATTCTTTGGAAGAAGTGGTCCATGCTGATCAGAGCTCCTGCACTTTTGATAACCTGAGTCCCGGCCTGGAGTACA ATGTCAGTGTTTACACTGTCAAGGATGACAAGGAAAGTGTCCCTATCTCTGATACCATCATCCCAGCTGTTCCTCCTCCCACTGACCTGCGATTCACCAA CATTGGTCCAGACACCATGCGTGTCACCTGGGCTCCACCCCCATCCATTGATTTAACCAACTTCCTGGTGCGTTACTCACCTGTGAAAAATGAGGAAGAT GTTGCAGAGTTGTCAATTTCTCCTTCAGACAATGCAGTGGTCTTAACAAATCTCCTGCCTGGTACAGAATATGTAGTGAGTGTCTCCAGTGTCTACGAAC AACATGAGAGCACACCTCTTAGAGGAAGACAGAAAACAGGTCTTGATTCCCCAACTGGCATTGACTTTTCTGATATTACTGCCAACTCTTTTACTGTGCA CTGGATTGCTCCTCGAGCCACCATCACTGGCTACAGGATCCGCCATCATCCCGAGCACTTCAGTGGGAGACCTCGAGAAGATCGGGTGCCCCACTCTCGG AATTCCATCACCCTCACCAACCTCACTCCAGGCACAGAGTATGTGGTCAGCATCGTTGCTCTTAATGGCAGAGAGGAAAGTCCCTTATTGATTGGCCAAC AATCAACAGTTTCTGATGTTCCGAGGGACCTGGAAGTTGTTGCTGCGACCCCCACCAGCCTACTGATCAGCTGGGATGCTCCTGCTGTCACAGTGAGATA TTACAGGATCACTTACGGAGAGACAGGAGGAAATAGCCCTGTCCAGGAGTTCACTGTGCCTGGGAGCAAGTCTACAGCTACCATCAGCGGCCTTAAACCT GGAGTTGATTATACCATCACTGTGTATGCTGTCACTGGCCGTGGAGACAGCCCCGCAAGCAGCAAGCCAATTTCCATTAATTACCGAACAGAAATTGACA AACCATCCCAGATGCAAGTGACCGATGTTCAGGACAACAGCATTAGTGTCAAGTGGCTGCCTTCAAGTTCCCCTGTTACTGGTTACAGAGTAACCACCAC TCCCAAAAATGGACCAGGACCAACAAAAACTAAAACTGCAGGTCCAGATCAAACAGAAATGACTATTGAAGGCTTGCAGCCCACAGTGGAGTATGTGGTT AGTGTCTATGCTCAGAATCCAAGCGGAGAGAGTCAGCCTCTGGTTCAGACTGCAGTAACCACTATTCCTGCACCAACTGACCTGAAGTTCACTCAGGTCA CACCCACAAGCCTGAGCGCCCAGTGGACACCACCCAATGTTCAGCTCACTGGATATCGAGTGCGGGTGACCCCCAAGGAGAAGACCGGACCAATGAAAGA AATCAACCTTGCTCCTGACAGCTCATCCGTGGTTGTATCAGGACTTATGGTGGCCACCAAATATGAAGTGAGTGTCTATGCTCTTAAGGACACTTTGACA AGCAGACCAGCTCAGGGAGTTGTCACCACTCTGGAGAATGTCAGCCCACCAAGAAGGGCTCGTGTGACAGATGCTACTGAGACCACCATCACCATTAGCT GGAGAACCAAGACTGAGACGATCACTGGCTTCCAAGTTGATGCCGTTCCAGCCAATGGCCAGACTCCAATCCAGAGAACCATCAAGCCAGATGTCAGAAG CTACACCATCACAGGTTTACAACCAGGCACTGACTACAAGATCTACCTGTACACCTTGAATGACAATGCTCGGAGCTCCCCTGTGGTCATCGACGCCTCC ACTGCCATTGATGCACCATCCAACCTGCGTTTCCTGGCCACCACACCCAATTCCTTGCTGGTATCATGGCAGCCGCCACGTGCCAGGATTACCGGCTACA TCATCAAGTATGAGAAGCCTGGGTCTCCTCCCAGAGAAGTGGTCCCTCGGCCCCGCCCTGGTGTCACAGAGGCTACTATTACTGGCCTGGAACCGGGAAC CGAATATACAATTTATGTCATTGCCCTGAAGAATAATCAGAAGAGCGAGCCCCTGATTGGAAGGAAAAAGACAGACGAGCTTCCCCAACTGGTAACCCTT CCACACCCCAATCTTCATGGACCAGAGATCTTGGATGTTCCTTCCACAGTTCAAAAGACCCCTTTCGTCACCCACCCTGGGTATGACACTGGAAATGGTA TTCAGCTTCCTGGCACTTCTGGTCAGCAACCCAGTGTTGGGCAACAAATGATCTTTGAGGAACATGGTTTTAGGCGGACCACACCGCCCACAACGGCCAC CCCCATAAGGCATAGGCCAAGACCATACCCGCCGAATGTAGGACAAGAAGCTCTCTCTCAGACAACCATCTCATGGGCCCCATTCCAGGACACTTCTGAG TACATCATTTCATGTCATCCTGTTGGCACTGATGAAGAACCCTTACAGTTCAGGGTTCCTGGAACTTCTACCAGTGCCACTCTGACAGGCCTCACCAGAG GTGCCACCTACAACGTCATAGTGGAGGCACTGAAAGACCAGCAGAGGCATAAGGTTCGGGAAGAGGTTGTTACCGTGGGCAACTCTGTCAACGAAGGCTT GAACCAACCTACGGATGACTCGTGCTTTGACCCCTACACAGTTTCCCATTATGCCGTTGGAGATGAGTGGGAACGAATGTCTGAATCAGGCTTTAAACTG TTGTGCCAGTGCTTAGGCTTTGGAAGTGGTCATTTCAGATGTGATTCATCTAGATGGTGCCATGACAATGGTGTGAACTACAAGATTGGAGAGAAGTGGG ACCGTCAGGGAGAAAATGGCCAGATGATGAGCTGCACATGTCTTGGGAACGGAAAAGGAGAATTCAAGTGTGACCCTCATGAGGCAACGTGTTATGATGA TGGGAAGACATACCACGTAGGAGAACAGTGGCAGAAGGAATATCTCGGTGCCATTTGCTCCTGCACATGCTTTGGAGGCCAGCGGGGCTGGCGCTGTGAC AACTGCCGCAGACCTGGGGGTGAACCCAGTCCCGAAGGCACTACTGGCCAGTCCTACAACCAGTATTCTCAGAGATACCATCAGAGAACAAACACTAATG TTAATTGCCCAATTGAGTGCTTCATGCCTTTAGATGTACAGGCTGACAGAGAAGATTCCCGAGAGTAAATCATCTTTCCAATCCAGAGGAACAAGCATGT CTCTCTGCCAAGATCCATCTAAACTGGAGTGATGTTAGCAGACCCAGCTTAGAGTTCTTCTTTCTTTCTTAAGCCCTTTGCTCTGGAGGAAGTTCTCCAG CTTCAGCTCAACTCACAGCTTCTCCAAGCATCACCCTGGGAGTTTCCTGAGGGTTTTCTCATAAATGAGGGCTGCACATTGCCTGTTCTGCTTCGAAGTA TTCAATACCGCTCAGTATTTTAAATGAAGTGATTCTAAGATTTGGTTTGGGATCAATAGGAAAGCATATGCAGCCAACCAAGATGCAAATGTTTTGAAAT GATATGACCAAAATTTTAAGTAGGAAAGTCACCCAAACACTTCTGCTTTCACTTAAGTGTCTGGCCCGCAATACTGTAGGAACAAGCATGATCTTGTTAC TGTGATATTTTAAATATCCACAGTACTCACTTTTTCCAAATGATCCTAGTAATTGCCTAGAAATATCTTTCTCTTACCTGTTATTTATCAATTTTTCCCA GTATTTTTATACGGAAAAAATTGTATTGAAAACACTTAGTATGCAGTTGATAAGAGGAATTTGGTATAATTATGGTGGGTGATTATTTTTTATACTGTAT GTGCCAAAGCTTTACTACTGTGGAAAGACAACTGTTTTAATAAAAGATTTACATTCCACAACTTGAAGTTCATCTATTTGATATAAGACACCTTCGGGGG AAATAATTCCTGTGAATATTCTTTTTCAATTCAGCAAACATTTGAAAATCTATGATGTGCAAGTCTAATTGTTGATTTCAGTACAAGATTTTCTAAATCA GTTGCTACAAAAACTGATTGGTTTTTGTCACTTCATCTCTTCACTAATGGAGATAGCTTTACACTTTCTGCTTTAATAGATTTAAGTGGACCCCAATATT TATTAAAATTGCTAGTTTACCGTTCAGAAGTATAATAGAAATAATCTTTAGTTGCTCTTTTCTAACCATTGTAATTCTTCCCTTCTTCCCTCCACCTTTC CTTCATTGAATAAACCTCTGTTCAAAGAGATTGCCTGCAAGGGAAATAAAAATGACTAAGATATTAAAAGTATTTGAATAGTATAATATGGAGGAGTTTT ATCTTAGGGAAACCCCATGGTATGATAACCCCCATCTAACATGTCTTACTTTGGGTCAGCTGACACTTTTGGCATGGCTTGATAAACTCCCAGCTAAACA GTTTGTTTACTCCTGATCTGTAAAGGTCATTTCTTTTTCAATTTAACATTGAGGAAACAAACTTTGGGATTAAATTTGACATTCAGGCCAGGCGCAGTGG CTCACACCTCTAATCCCAGCACTTTGGGAGGCTGAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCTTGTCT CTATTAAAAATACAAATGTTACCAGGCATGGCAGTGGGCGTCTTTGGTCCCGGCTACTCAGAAGGCTGAGGTAGGAGAATGGCTTGAACCCAGAAGGCGG AGGTTGCAGTGAGCTGAGATTGTGCCATTGAACTCCAGCATGGGGGACAGAGCAAGACTCCATCCCAAAAAACATAAATAAATAAATGTGACATTCAGAA TAGTAAATAGTGGAAATGGAAATAATTATTAGTAAAAAATTAGTAGTTCATAATAAACAAGACATGCAAAGCACTTTTTAAATATACTAATGTACAATGA AAGAAGGTATTTCAATAAACACCTGGCAAAGAATATTAAAACTAAATACAGAAAGATACTTCCTCATGTTCATTTGAAAAAAAAAAATACTAACTCCCAT TTGAATTGATTTACAGTTTATAAAATGCTTTGACATTTAGCTATCTCATTTAGGGGAGGTTTTAGAGCTTAATTTTACAGGGCATGAAGCTCAGATGAGG TTTCCTTAGCGAAATACAGACCCAGCCCCTGGACTTCTATTTATTACTGATCTTTAAGCTTTATCAGCCCAATAGTCACCAAGAGAGCTGCTCTGTATGT TTTTTAAAAATCACAGAAAGTACAAAATAAAGGTGATATTAAACGACTGTC

FN1.u.f.55 (forward primer)
FN1.u.r.66 (reverse primer)
Single exon skipping

Frame 0

RGGDSPAGLSSPAPRASRGAGGDRPI*APAPGA RTPAPAVLHRGRRGNPRREREEGTCSHNFSGPLH PFCPSTRPLPHPLAPTFLEATTPGRH*KGFFPQ VAKGSKLGGNLPPGAGVSPPPSQHA*GSGARAA AAGRPVPGDSGALHGSLEEQEAGSANGSAPVPGG CQSKQARLL*QWKTLSDKSTVGADLPRQCVGLY LLWRKPRF*LRE*T*S*RDLL*QVHWEHLPSG* HL*AS*RLHDLGLYLHRGWARENKLYHRKPLP*R GSVLQDW*HLEETT*DWWLHVRVCVSW*WKRRM DLQAHS*EVF*SCCWDFLCGRRNVGEALPRLDD GRLYLPGRRQRTHHLHF*K*MQRSGHKDIL*NWR HLEQEG*SRKPAPVHLHRQRPRRVEV*EAHLCA DHIERIWPLHRCSCSCLPTAASPPASSLWPLCH RQWCGLLCGDAVAEDTRK*ANALHVPGQRSQLPR DSCNPDLRWQLKWRAMCLTIHLQWQDVLLLHHR RATGRTSLVQHNFEL*AGPEILFLHRPHCFGSD SRRKFQWCLVPLPLPIQQPQLH*LHF*GQKRQHE VVWDHTEL*CRPEVWVLPHGCPRGNLHNQ*RGH VPHWRSVG*AA*HGSHDEVHVCWEWSWGMDMHC LLAASRSVHC**HHLQCERHIPQAS*RGAHAELY MLRSGSGQVEV*SRRPMPGFRDWDVLSNWRFMG EVCAWCQIPVLLLWPWHWGVALPTFTDLSKLKW SCRSIYH*DSESAQLPPHPVECTTAISHFQVHSQ VET*KFCRPLEGSYHTRPLKLLHHQRPEAWCGI RGPAHQHPAVRPPRSDSL*LHHHQHQHTCDQQH RDRRDDSLFSSCGHF*ICDRNHSQ*LCGLLGLSF RHRVGIPGGI*AE*GGR*ATVPGSSKHSHFCEH P*PASWPKIHCKCLSDI*GWGAEFDPVYFTNNS A*CPS*HDCGPS**HLNCCSLEQTPGSHHRVQNS LFAISRR*QHRTQPS*NCKLRHPQ*LATWCSV* HHYLCCGRKSRKYTCCHSTRNHWHPTLRYSALS QGPAVCGSDRREGHHHVDTA*ECSDRLPCGCDPR QPAWRARAEAAHQQEHLCRSHRAVPWGHLLLQS LCSEPWEGEQASDCSTDNQTGCSH*PPVCQ*N* FYCPGEMDSTSGPDNRIPTDRGPYPKRTAQAVQC GSLCLQVPTEESAACI*VHRIPRGHKGQPREPQ SHWSLYHTAAWELYSTLQHRGD*DHHCDHMDAC SKNWF*AGCTTKPGRRGTTRSDFRLRKHRCVRLD SRSRIRLHHPSPERWTGKRCANCKQSGDTIVST NKLASGGKP*HWSAHSLLGEEHHPRHYWL*NYH NPYKRPAGKFFGRSGPC*SELLHF**PESRPGVQ CQCLHCQG*QGKCPYL*YHHPSCSSSH*PAIHQ HWSRHHACHLGSTPIH*FNQLPGALLTCEK*GR CCRVVNFSFRQCSGLNKSPAWYRICSECLQCLRT T*EHTS*RKTENRS*FPNWH*LF*YYCQLFYCA LDCSSSHHHWLQDPPSSRALQWETSRRSGAPLS EFHHPHQPHSRHRVCGQHRCS*WQRGKSLIDWPT INSF*CSEGPGSCCCDPHQPTDQLGCSCCHSEI LQDHLRRDRRK*PCPGVHCAWEQVYSYHQRP*T WS*LYHHCVCCHWPWRQPRKQQANFH*LPNRN*Q TIPDASDRCSGQQH*CQVAAFKFPCYWLQSNHH SQKWTRTNKN*NCRSRSNRNDY*RLAAHSGVCG *CLCSESKRRESASGSDCSNHYSCTN*PEVHSGH THKPERPVDTTQCSAHWISSAGDPQGEDRTNER NQPCS*QLIRGCIRTYGGHQI*SECLCS*GHFD KQTSSGSCHHSGECQPTKKGSCDRCY*DHHHH*L ENQD*DDHWLPS*CRSSQWPDSNPENHQARCQK LHHHRFTTRH*LQDLPVHLE*QCSELPCGHRRL HCH*CTIQPAFPGHHTQFLAGIMAAATCQDYRLH HQV*EAWVSSQRSGPSAPPWCHRGYYYWPGTGN RIYNLCHCPEE*SEERAPDWKEKDRRASPTGNP STPQSSWTRDLGCSFHSSKDPFRHPPWV*HWKWY SASWHFWSATQCWATNDL*GTWF*ADHTAHNGH PHKA*AKTIPAECRTRSSLSDNHLMGPIPGHF* VHHFMSSCWH**RTLTVQGSWNFYQCHSDRPHQR CHLQRHSGGTERPAEA*GSGRGCYRGQLCQRRL EPTYG*LVL*PLHSFPLCRWR*VGTNV*IRL*T VVPVLRLWKWSFQM*FI*MVP*QWCELQDWREVG PSGRKWPDDELHMSWERKRRIQV*PS*GNVL** WEDIPRRRTVAEGISRCHLLLHMLWRPAGLAL* QLPQTWG*TQSRRHYWPVLQPVFSEIPSENKH*C *LPN*VLHAFRCTG*QRRFPRVNHLSNPEEQAC LSAKIHLNWSDVSRPSLEFFFLS*ALCSGGSSP ASAQLTASPSITLGVS*GFSHK*GLHIACSASKY SIPLSILNEVILRFGLGSIGKHMQPTKMQMF*N DMTKILSRKVTQTLLLSLKCLARNTVGTSMILL L*YFKYPQYSLFPNDPSNCLEISFSYLLFINFSQ YFYTEKIVLKTLSMQLIRGIWYNYGG*LFFILY VPKLYYCGKTTVLIKDLHSTT*SSSI*YKTPSG EIIPVNILFQFSKHLKIYDVQV*LLISVQDFLNQ LLQKLIGFCHFISSLMEIALHFLL**I*VDPNI Y*NC*FTVQKYNRNNL*LLFSNHCNSSLLPSTF PSLNKPLFKEIACKGNKND*DIKSI*IV*YGGVL S*GNPMV**PPSNMSYFGSADTFGMA**TPS*T VCLLLICKGHFFFNLTLRKQTLGLNLTFRPGAV AHTSNPSTLGG*GRWIT*GQEFETSLANMVKPCL Y*KYKCYQAWQWASLVPATQKAEVGEWLEPRRR RLQ*AEIVPLNSSMGDRARLHPKKHK*INVTFR IVNSGNGNNY**KISSS**TRHAKHFLNILMYNE RRYFNKHLAKNIKTKYRKILPHVHLKKKNTNSH LN*FTVYKML*HLAISFRGGFRA*FYRA*SSDE VSLAKYRPSPWTSIYY*SLSFISPIVTKRAALYV F*KSQKVQNKGDIKRL

Frame 1

GAGTARRVSPPPRPGPPEGREGTVPYKPRLPAL GRPRRLCCTGGGEGTPGASGKRGPAATTSLVLC IPSVPPPVPFPTLWPPPSWRRQPPGGIRRDFSRR LRREANLVATCLPVRASLPHRLNMLRGPGPGLL LLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPV AVSQSKPGCYDNGKHYQINQQWERTYLGNALVCT CYGGSRGFNCESKPEAEETCFDKYTGNTYRVGD TYERPKDSMIWDCTCIGAGRGRISCTIANRCHE GGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEW TCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMM VDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIG DTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQ TTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVT DSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQ ETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTE GRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQT RGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNM KWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVM YRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIA YSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNC TCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWE KYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSG PVEVFITETPSQPNSHPIQWNAPQPSHISKYIL RWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVY EGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNT VTGETTPFSPLVATSESVTEITASSFVVSWVSA SDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNI PDLLPGRKYIVNVYQISEDGEQSLILSTSQTTA PDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRI VYSPSVEGSSTELNLPETANSVTLSDLQPGVQYN ITIYAVEENQESTPVVIQQETTGTPRSDTVPSP RDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIP VNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKV FAVSHGRESKPLTAQQTTKLDAPTNLQFVNETD STVLVRWTPPRAQITGYRLTVGLTRRGQPRQYN VGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPK ATGVFTTLQPGSSIPPYNTEVTETTIVITWTPA PRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGL TPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPP TNLHLEANPDTGVLTVSWERSTTPDITGYRITT TPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEY NVSVYTVKDDKESVPISDTIIPAVPPPTDLRFTN IGPDTMRVTWAPPPSIDLTNFLVRYSPVKNEED VAELSISPSDNAVVLTNLLPGTEYVVSVSSVYE QHESTPLRGRQKTGLDSPTGIDFSDITANSFTVH WIAPRATITGYRIRHHPEHFSGRPREDRVPHSR NSITLTNLTPGTEYVVSIVALNGREESPLLIGQ QSTVSDVPRDLEVVAATPTSLLISWDAPAVTVRY YRITYGETGGNSPVQEFTVPGSKSTATISGLKP GVDYTITVYAVTGRGDSPASSKPISINYRTEID KPSQMQVTDVQDNSISVKWLPSSSPVTGYRVTTT PKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVV SVYAQNPSGESQPLVQTAVTTIPAPTDLKFTQV TPTSLSAQWTPPNVQLTGYRVRVTPKEKTGPMKE INLAPDSSSVVVSGLMVATKYEVSVYALKDTLT SRPAQGVVTTLENVSPPRRARVTDATETTITIS WRTKTETITGFQVDAVPANGQTPIQRTIKPDVRS YTITGLQPGTDYKIYLYTLNDNARSSPVVIDAS TAIDAPSNLRFLATTPNSLLVSWQPPRARITGY IIKYEKPGSPPREVVPRPRPGVTEATITGLEPGT EYTIYVIALKNNQKSEPLIGRKKTDELPQLVTL PHPNLHGPEILDVPSTVQKTPFVTHPGYDTGNG IQLPGTSGQQPSVGQQMIFEEHGFRRTTPPTTAT PIRHRPRPYPPNVGQEALSQTTISWAPFQDTSE YIISCHPVGTDEEPLQFRVPGTSTSATLTGLTR GATYNVIVEALKDQQRHKVREEVVTVGNSVNEGL NQPTDDSCFDPYTVSHYAVGDEWERMSESGFKL LCQCLGFGSGHFRCDSSRWCHDNGVNYKIGEKW DRQGENGQMMSCTCLGNGKGEFKCDPHEATCYDD GKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCD NCRRPGGEPSPEGTTGQSYNQYSQRYHQRTNTN VNCPIECFMPLDVQADREDSRE*IIFPIQRNKHV SLPRSI*TGVMLADPA*SSSFFLKPFALEEVLQ LQLNSQLLQASPWEFPEGFLINEGCTLPVLLRS IQYRSVF*MK*F*DLVWDQ*ESICSQPRCKCFEM I*PKF*VGKSPKHFCFHLSVWPAIL*EQA*SCY CDILNIHSTHFFQMILVIA*KYLSLTCYLSIFP SIFIRKKLY*KHLVCS**EEFGIIMVGDYFLYCM CQSFTTVERQLF**KIYIPQLEVHLFDIRHLRG K*FL*IFFFNSANI*KSMMCKSNC*FQYKIF*I SCYKN*LVFVTSSLH*WR*LYTFCFNRFKWTPIF IKIASLPFRSIIEIIFSCSFLTIVILPFFPPPF LH*INLCSKRLPAREIKMTKILKVFE*YNMEEF YLRETPWYDNPHLTCLTLGQLTLLAWLDKLPAKQ FVYS*SVKVISFSI*H*GNKLWD*I*HSGQAQW LTPLIPALWEAEAGGSPEVRSLRPAWPTW*NLV SIKNTNVTRHGSGRLWSRLLRRLR*ENGLNPEGG GCSELRLCH*TPAWGTEQDSIPKNINK*M*HSE **IVEMEIIISKKLVVHNKQDMQSTF*IY*CTM KEGISINTWQRILKLNTERYFLMFI*KKKILTPI *IDLQFIKCFDI*LSHLGEVLELNFTGHEAQMR FP*RNTDPAPGLLFITDL*ALSAQ*SPRELLCM FFKNHRKYKIKVILNDC

Frame 2

GRGQPGGSLLPRAPGLQRGGRGPSHISPGSRRS DARAGCAAQGEEREPQARAGRGDLQPQLLWSSA SLLSLHPSPSPPSGPHLLGGDNPREALEGIFPA GCEGKQTWWQLASRCGRLSPTVSTCLGVRGPGCC CWPSSAWGQRCPPREPRRARGRLSKWFSPSPRW LSVKASPVVMTMENTIR*INSGSGPT*AMRWFV LVMEEAEVLTARVNLKLKRLALTSTLGTLTEWVT LMSVLKTP*SGTVPASGLGEGE*AVPSQTAAMK GVSPTRLVTPGGDHMRLVVTC*SVCVLVMEKEN GPASP*LRSVLIMLLGLPMWSEKRGRSPTKAG*W *IVLAWEKAADASLALLEIDATIRTQGHPIELE TPGARRIIEETCSSASAQATAEESGSVRGTPLC RPHRADLAPSPMFVQLFTNRSLTPSLLPMATVSQ TVVWSTLWGCSG*RHKEISKCFARAWATESAAK RQL*PRLTVATQMESHVSYHSPTMAGRSTPAPQ KGDRTDIFGAAQLRIMSRTRNTLSAQTTLFWFRL EEEIPMVPCATSPSYTTTTITLIALLRAEETT* SGVGPHRTMMPTRSLGSAPWLPTRKSAQPMKGS CTALEISGISSMTWVT**GARVLGMVVGNGHALP TRSFEISALLMTSLTM*TTHSTSVMKRGTC*TV HASVRVGAGGSVIPSTNARIQRLGRFIKLEIHG RSMCMVSDTSATAMAVALGSGIANLYRPIQAQVV LSKYLSLRLRVSPTPTPSSGMHHSHLTFPSTFS GGDLKIL*AVGRKLPYQAT*TPTPSKA*SLVWY TRASSSASSSTATKK*LALTSPPPAPAHL*PATP *QERRLPFLLLWPLLNL*PKSQPVALWSPGSQL PTPCRDSGWNMS*VRREMSHSTWIFQAQPLL*T SLTCFLAENTL*MSIRYLRMGSRV*SCLLHKQQR LMPLLTRLWTKLMTPQLLFAGADPRLPSQGTE* SIRHQ*KVAAQNSTFLKLQTPSPSVTCNLVFSI TSLSMLWKKIKKVHLLSFNKKPLAPHAQIQCPLP GTCSLWK*QT*RSPSCGHRLRVQ*PATVWM*SP STCLASTGRGCPSAGTPLQKSPGCPLGSPITSK SLQ*AMGGRASL*LLNRQPNWMLPLTSSLSMKLI LLSW*DGLHLGPR*QDTD*PWALPEEDSPGSTM WVPLSPSTH*GICSLHLSTPYPSWP*RATKRAP KPLESLPHCSLGALFHLTTPR*LRPPL*SHGRLL QELVLSWVYDQAREERHHEK*LQTQEASLCPA* LQE*NTSTPSKS*EMDRKEMRQL*TKW*HHCLH QQTCIWRQTLTLECSQSPGRGAPPQTLLVIELPQ PLQTASREILWKKWSMLIRAPALLIT*VPAWST MSVFTLSRMTRKVSLSLIPSSQLFLLPLTCDSP TLVQTPCVSPGLHPHPLI*PTSWCVTHL*KMRKM LQSCQFLLQTMQWS*QISCLVQNM**VSPVSTN NMRAHLLEEDRKQVLIPQLALTFLILLPTLLLC TGLLLEPPSLATGSAIIPSTSVGDLEKIGCPTLG IPSPSPTSLQAQSMWSASLLLMAERKVPY*LAN NQQFLMFRGTWKLLLRPPPAY*SAGMLLLSQ*D ITGSLTERQEEIALSRSSLCLGASLQLPSAALNL ELIIPSLCMLSLAVETAPQAASQFPLITEQKLT NHPRCK*PMFRTTALVSSGCLQVPLLLVTE*PP LPKMDQDQQKLKLQVQIKQK*LLKACSPQWSMWL VSMLRIQAERVSLWFRLQ*PLFLHQLT*SSLRS HPQA*APSGHHPMFSSLDIECG*PPRRRPDQ*K KSTLLLTAHPWLYQDLWWPPNMK*VSMLLRTL*Q ADQLRELSPLWRMSAHQEGLV*QMLLRPPSPLA GEPRLRRSLASKLMPFQPMARLQSREPSSQMSE ATPSQVYNQALTTRSTCTP*MTMLGAPLWSSTPP LPLMHHPTCVSWPPHPIPCWYHGSRHVPGLPAT SSSMRSLGLLPEKWSLGPALVSQRLLLLAWNRE PNIQFMSLP*RIIRRASP*LEGKRQTSFPNW*PF HTPIFMDQRSWMFLPQFKRPLSSPTLGMTLEMV FSFLALLVSNPVLGNK*SLRNMVLGGPHRPQRP PP*GIGQDHTRRM*DKKLSLRQPSHGPHSRTLLS TSFHVILLALMKNPYSSGFLELLPVPL*QASPE VPPTTS*WRH*KTSRGIRFGKRLLPWATLSTKA *TNLRMTRALTPTQFPIMPLEMSGNECLNQALNC CASA*ALEVVISDVIHLDGAMTMV*TTRLERSG TVREKMAR**AAHVLGTEKENSSVTLMRQRVMM MGRHTT*ENSGRRNISVPFAPAHALEASGAGAVT TAADLGVNPVPKALLASPTTSILRDTIREQTLM LIAQLSASCL*MYRLTEKIPESKSSFQSRGTSM SLCQDPSKLE*C*QTQLRVLLSFLSPLLWRKFSS FSSTHSFSKHHPGSFLRVFS*MRAAHCLFCFEV FNTAQYFK*SDSKIWFGINRKAYAANQDANVLK *YDQNFK*ESHPNTSAFT*VSGPQYCRNKHDLVT VIF*ISTVLTFSK*S**LPRNIFLLPVIYQFFP VFLYGKNCIENT*YAVDKRNLV*LWWVIIFYTV CAKALLLWKDNCFNKRFTFHNLKFIYLI*DTFGG NNSCEYSFSIQQTFENL*CASLIVDFSTRFSKS VATKTDWFLSLHLFTNGDSFTLSALIDLSGPQY LLKLLVYRSEV**K*SLVALF*PL*FFPSSLHLS FIE*TSVQRDCLQGK*K*LRY*KYLNSIIWRSF ILGKPHGMITPI*HVLLWVS*HFWHGLINSQLN SLFTPDL*RSFLFQFNIEETNFGIKFDIQARRSG SHL*SQHFGRLRQVDHLRSGV*DQPGQHGETLS LLKIQMLPGMAVGVFGPGYSEG*GRRMA*TQKA EVAVS*DCAIELQHGGQSKTPSQKT*INKCDIQN SK*WKWK*LLVKN**FIINKTCKALFKYTNVQ* KKVFQ*TPGKEY*N*IQKDTSSCSFEKKKY*LP FELIYSL*NALTFSYLI*GRF*SLILQGMKLR*G FLSEIQTQPLDFYLLLIFKLYQPNSHQESCSVC FLKITESTK*R*Y*TTV

Sequence FN1.eAug05

CGGGGCGGGGACAGCCCGGCGGGTCTCTCCTCCCCCGCGCCCCGGGCCTCCAGAGGGGCGGGAGGGGACCGTCCCATATAAGCCCCGGCTCCCGGCGCTC GGACGCCCGCGCCGGCTGTGCTGCACAGGGGGAGGAGAGGGAACCCCAGGCGCGAGCGGGAAGAGGGGACCTGCAGCCACAACTTCTCTGGTCCTCTGCA TCCCTTCTGTCCCTCCACCCGTCCCCTTCCCCACCCTCTGGCCCCCACCTTCTTGGAGGCGACAACCCCCGGGAGGCATTAGAAGGGATTTTTCCCGCAG GTTGCGAAGGGAAGCAAACTTGGTGGCAACTTGCCTCCCGGTGCGGGCGTCTCTCCCCCACCGTCTCAACATGCTTAGGGGTCCGGGGCCCGGGCTGCTG CTGCTGGCCGTCCAGTGCCTGGGGACAGCGGTGCCCTCCACGGGAGCCTCGAAGAGCAAGAGGCAGGCTCAGCAAATGGTTCAGCCCCAGTCCCCGGTGG CTGTCAGTCAAAGCAAGCCCGGTTGTTATGACAATGGAAAACACTATCAGATAAATCAACAGTGGGAGCGGACCTACCTAGGCAATGCGTTGGTTTGTAC TTGTTATGGAGGAAGCCGAGGTTTTAACTGCGAGAGTAAACCTGAAGCTGAAGAGACTTGCTTTGACAAGTACACTGGGAACACTTACCGAGTGGGTGAC ACTTATGAGCGTCCTAAAGACTCCATGATCTGGGACTGTACCTGCATCGGGGCTGGGCGAGGGAGAATAAGCTGTACCATCGCAAACCGCTGCCATGAAG GGGGTCAGTCCTACAAGATTGGTGACACCTGGAGGAGACCACATGAGACTGGTGGTTACATGTTAGAGTGTGTGTGTCTTGGTAATGGAAAAGGAGAATG GACCTGCAAGCCCATAGCTGAGAAGTGTTTTGATCATGCTGCTGGGACTTCCTATGTGGTCGGAGAAACGTGGGAGAAGCCCTACCAAGGCTGGATGATG GTAGATTGTACTTGCCTGGGAGAAGGCAGCGGACGCATCACTTGCACTTCTAGAAATAGATGCAACGATCAGGACACAAGGACATCCTATAGAATTGGAG ACACCTGGAGCAAGAAGGATAATCGAGGAAACCTGCTCCAGTGCATCTGCACAGGCAACGGCCGAGGAGAGTGGAAGTGTGAGAGGCACACCTCTGTGCA GACCACATCGAGCGGATCTGGCCCCTTCACCGATGTTCGTGCAGCTGTTTACCAACCGCAGCCTCACCCCCAGCCTCCTCCCTATGGCCACTGTGTCACA GACAGTGGTGTGGTCTACTCTGTGGGGATGCAGTGGCTGAAGACACAAGGAAATAAGCAAATGCTTTGCACGTGCCTGGGCAACGGAGTCAGCTGCCAAG AGACAGCTGTAACCCAGACTTACGGTGGCAACTCAAATGGAGAGCCATGTGTCTTACCATTCACCTACAATGGCAGGACGTTCTACTCCTGCACCACAGA AGGGCGACAGGACGGACATCTTTGGTGCAGCACAACTTCGAATTATGAGCAGGACCAGAAATACTCTTTCTGCACAGACCACACTGTTTTGGTTCAGACT CGAGGAGGAAATTCCAATGGTGCCTTGTGCCACTTCCCCTTCCTATACAACAACCACAATTACACTGATTGCACTTCTGAGGGCAGAAGAGACAACATGA AGTGGTGTGGGACCACACAGAACTATGATGCCGACCAGAAGTTTGGGTTCTGCCCCATGGCTGCCCACGAGGAAATCTGCACAACCAATGAAGGGGTCAT GTACCGCATTGGAGATCAGTGGGATAAGCAGCATGACATGGGTCACATGATGAGGTGCACGTGTGTTGGGAATGGTCGTGGGGAATGGACATGCATTGCC TACTCGCAGCTTCGAGATCAGTGCATTGTTGATGACATCACTTACAATGTGAACGACACATTCCACAAGCGTCATGAAGAGGGGCACATGCTGAACTGTA CATGCTTCGGTCAGGGTCGGGGCAGGTGGAAGTGTGATCCCGTCGACCAATGCCAGGATTCAGAGACTGGGACGTTTTATCAAATTGGAGATTCATGGGA GAAGTATGTGCATGGTGTCAGATACCAGTGCTACTGCTATGGCCGTGGCATTGGGGAGTGGCATTGCCAACCTTTACAGACCTATCCAAGCTCAAGTGGT CCTGTCGAAGTATTTATCACTGAGACTCCGAGTCAGCCCAACTCCCACCCCATCCAGTGGAATGCACCACAGCCATCTCACATTTCCAAGTACATTCTCA GGTGGAGACCTAAAAATTCTGTAGGCCGTTGGAAGGAAGCTACCATACCAGGCCACTTAAACTCCTACACCATCAAAGGCCTGAAGCCTGGTGTGGTATA CGAGGGCCAGCTCATCAGCATCCAGCAGTACGGCCACCAAGAAGTGACTCGCTTTGACTTCACCACCACCAGCACCAGCACACCTGTGACCAGCAACACC GTGACAGGAGAGACGACTCCCTTTTCTCCTCTTGTGGCCACTTCTGAATCTGTGACCGAAATCACAGCCAGTAGCTTTGTGGTCTCCTGGGTCTCAGCTT CCGACACCGTGTCGGGATTCCGGGTGGAATATGAGCTGAGTGAGGAGGGAGATGAGCCACAGTACCTGGATCTTCCAAGCACAGCCACTTCTGTGAACAT CCCTGACCTGCTTCCTGGCCGAAAATACATTGTAAATGTCTATCAGATATCTGAGGATGGGGAGCAGAGTTTGATCCTGTCTACTTCACAAACAACAGCG CCTGATGCCCCTCCTGACACGACTGTGGACCAAGTTGATGACACCTCAATTGTTGTTCGCTGGAGCAGACCCCAGGCTCCCATCACAGGGTACAGAATAG TCTATTCGCCATCAGTAGAAGGTAGCAGCACAGAACTCAACCTTCCTGAAACTGCAAACTCCGTCACCCTCAGTGACTTGCAACCTGGTGTTCAGTATAA CATCACTATCTATGCTGTGGAAGAAAATCAAGAAAGTACACCTGTTGTCATTCAACAAGAAACCACTGGCACCCCACGCTCAGATACAGTGCCCTCTCCC AGGGACCTGCAGTTTGTGGAAGTGACAGACGTGAAGGTCACCATCATGTGGACACCGCCTGAGAGTGCAGTGACCGGCTACCGTGTGGATGTGATCCCCG TCAACCTGCCTGGCGAGCACGGGCAGAGGCTGCCCATCAGCAGGAACACCTTTGCAGAAGTCACCGGGCTGTCCCCTGGGGTCACCTATTACTTCAAAGT CTTTGCAGTGAGCCATGGGAGGGAGAGCAAGCCTCTGACTGCTCAACAGACAACCAAACTGGATGCTCCCACTAACCTCCAGTTTGTCAATGAAACTGAT TCTACTGTCCTGGTGAGATGGACTCCACCTCGGGCCCAGATAACAGGATACCGACTGACCGTGGGCCTTACCCGAAGAGGACAGCCCAGGCAGTACAATG TGGGTCCCTCTGTCTCCAAGTACCCACTGAGGAATCTGCAGCCTGCATCTGAGTACACCGTATCCCTCGTGGCCATAAAGGGCAACCAAGAGAGCCCCAA AGCCACTGGAGTCTTTACCACACTGCAGCCTGGGAGCTCTATTCCACCTTACAACACCGAGGTGACTGAGACCACCATTGTGATCACATGGACGCCTGCT CCAAGAATTGGTTTTAAGCTGGGTGTACGACCAAGCCAGGGAGGAGAGGCACCACGAGAAGTGACTTCAGACTCAGGAAGCATCGTTGTGTCCGGCTTGA CTCCAGGAGTAGAATACGTCTACACCATCCAAGTCCTGAGAGATGGACAGGAAAGAGATGCGCCAATTGTAAACAAAGTGGTGACACCATTGTCTCCACC AACAAACTTGCATCTGGAGGCAAACCCTGACACTGGAGTGCTCACAGTCTCCTGGGAGAGGAGCACCACCCCAGACATTACTGGTTATAGAATTACCACA ACCCCTACAAACGGCCAGCAGGGAAATTCTTTGGAAGAAGTGGTCCATGCTGATCAGAGCTCCTGCACTTTTGATAACCTGAGTCCCGGCCTGGAGTACA ATGTCAGTGTTTACACTGTCAAGGATGACAAGGAAAGTGTCCCTATCTCTGATACCATCATCCCAGCTGTTCCTCCTCCCACTGACCTGCGATTCACCAA CATTGGTCCAGACACCATGCGTGTCACCTGGGCTCCACCCCCATCCATTGATTTAACCAACTTCCTGGTGCGTTACTCACCTGTGAAAAATGAGGAAGAT GTTGCAGAGTTGTCAATTTCTCCTTCAGACAATGCAGTGGTCTTAACAAATCTCCTGCCTGGTACAGAATATGTAGTGAGTGTCTCCAGTGTCTACGAAC AACATGAGAGCACACCTCTTAGAGGAAGACAGAAAACAGGTCTTGATTCCCCAACTGGCATTGACTTTTCTGATATTACTGCCAACTCTTTTACTGTGCA CTGGATTGCTCCTCGAGCCACCATCACTGGCTACAGGATCCGCCATCATCCCGAGCACTTCAGTGGGAGACCTCGAGAAGATCGGGTGCCCCACTCTCGG AATTCCATCACCCTCACCAACCTCACTCCAGGCACAGAGTATGTGGTCAGCATCGTTGCTCTTAATGGCAGAGAGGAAAGTCCCTTATTGATTGGCCAAC AATCAACAGTTTCTGATGTTCCGAGGGACCTGGAAGTTGTTGCTGCGACCCCCACCAGCCTACTGATCAGCTGGGATGCTCCTGCTGTCACAGTGAGATA TTACAGGATCACTTACGGAGAGACAGGAGGAAATAGCCCTGTCCAGGAGTTCACTGTGCCTGGGAGCAAGTCTACAGCTACCATCAGCGGCCTTAAACCT GGAGTTGATTATACCATCACTGTGTATGCTGTCACTGGCCGTGGAGACAGCCCCGCAAGCAGCAAGCCAATTTCCATTAATTACCGAACAGAAATTGACA AACCATCCCAGATGCAAGTGACCGATGTTCAGGACAACAGCATTAGTGTCAAGTGGCTGCCTTCAAGTTCCCCTGTTACTGGTTACAGAGTAACCACCAC TCCCAAAAATGGACCAGGACCAACAAAAACTAAAACTGCAGGTCCAGATCAAACAGAAATGACTATTGAAGGCTTGCAGCCCACAGTGGAGTATGTGGTT AGTGTCTATGCTCAGAATCCAAGCGGAGAGAGTCAGCCTCTGGTTCAGACTGCAGTAACCAACATTGATCGCCCTAAAGGACTGGCATTCACTGATGTGG ATGTCGATTCCATCAAAATTGCTTGGGAAAGCCCACAGGGGCAAGTTTCCAGGTACAGGGTGACCTACTCGAGCCCTGAGGATGGAATCCATGAGCTATT CCCTGCACCTGATGGTGAAGAAGACACTGCAGAGCTGCAAGGCCTCAGACCGGGTTCTGAGTACACAGTCAGTGTGGTTGCCTTGCACGATGATATGGAG AGCCAGCCCCTGATTGGAACCCAGTCCACAGCTATTCCTGCACCAACTGACCTGAAGTTCACTCAGGTCACACCCACAAGCCTGAGCGCCCAGTGGACAC CACCCAATGTTCAGCTCACTGGATATCGAGTGCGGGTGACCCCCAAGGAGAAGACCGGACCAATGAAAGAAATCAACCTTGCTCCTGACAGCTCATCCGT GGTTGTATCAGGACTTATGGTGGCCACCAAATATGAAGTGAGTGTCTATGCTCTTAAGGACACTTTGACAAGCAGACCAGCTCAGGGAGTTGTCACCACT CTGGAGAATGTCAGCCCACCAAGAAGGGCTCGTGTGACAGATGCTACTGAGACCACCATCACCATTAGCTGGAGAACCAAGACTGAGACGATCACTGGCT TCCAAGTTGATGCCGTTCCAGCCAATGGCCAGACTCCAATCCAGAGAACCATCAAGCCAGATGTCAGAAGCTACACCATCACAGGTTTACAACCAGGCAC TGACTACAAGATCTACCTGTACACCTTGAATGACAATGCTCGGAGCTCCCCTGTGGTCATCGACGCCTCCACTGCCATTGATGCACCATCCAACCTGCGT TTCCTGGCCACCACACCCAATTCCTTGCTGGTATCATGGCAGCCGCCACGTGCCAGGATTACCGGCTACATCATCAAGTATGAGAAGCCTGGGTCTCCTC CCAGAGAAGTGGTCCCTCGGCCCCGCCCTGGTGTCACAGAGGCTACTATTACTGGCCTGGAACCGGGAACCGAATATACAATTTATGTCATTGCCCTGAA GAATAATCAGAAGAGCGAGCCCCTGATTGGAAGGAAAAAGACAGACGAGCTTCCCCAACTGGTAACCCTTCCACACCCCAATCTTCATGGACCAGAGATC TTGGATGTTCCTTCCACAGTTCAAAAGACCCCTTTCGTCACCCACCCTGGGTATGACACTGGAAATGGTATTCAGCTTCCTGGCACTTCTGGTCAGCAAC CCAGTGTTGGGCAACAAATGATCTTTGAGGAACATGGTTTTAGGCGGACCACACCGCCCACAACGGCCACCCCCATAAGGCATAGGCCAAGACCATACCC GCCGAATGTAGGACAAGAAGCTCTCTCTCAGACAACCATCTCATGGGCCCCATTCCAGGACACTTCTGAGTACATCATTTCATGTCATCCTGTTGGCACT GATGAAGAACCCTTACAGTTCAGGGTTCCTGGAACTTCTACCAGTGCCACTCTGACAGGCCTCACCAGAGGTGCCACCTACAACGTCATAGTGGAGGCAC TGAAAGACCAGCAGAGGCATAAGGTTCGGGAAGAGGTTGTTACCGTGGGCAACTCTGTCAACGAAGGCTTGAACCAACCTACGGATGACTCGTGCTTTGA CCCCTACACAGTTTCCCATTATGCCGTTGGAGATGAGTGGGAACGAATGTCTGAATCAGGCTTTAAACTGTTGTGCCAGTGCTTAGGCTTTGGAAGTGGT CATTTCAGATGTGATTCATCTAGATGGTGCCATGACAATGGTGTGAACTACAAGATTGGAGAGAAGTGGGACCGTCAGGGAGAAAATGGCCAGATGATGA GCTGCACATGTCTTGGGAACGGAAAAGGAGAATTCAAGTGTGACCCTCATGAGGCAACGTGTTATGATGATGGGAAGACATACCACGTAGGAGAACAGTG GCAGAAGGAATATCTCGGTGCCATTTGCTCCTGCACATGCTTTGGAGGCCAGCGGGGCTGGCGCTGTGACAACTGCCGCAGACCTGGGGGTGAACCCAGT CCCGAAGGCACTACTGGCCAGTCCTACAACCAGTATTCTCAGAGATACCATCAGAGAACAAACACTAATGTTAATTGCCCAATTGAGTGCTTCATGCCTT TAGATGTACAGGCTGACAGAGAAGATTCCCGAGAGTAAATCATCTTTCCAATCCAGAGGAACAAGCATGTCTCTCTGCCAAGATCCATCTAAACTGGAGT GATGTTAGCAGACCCAGCTTAGAGTTCTTCTTTCTTTCTTAAGCCCTTTGCTCTGGAGGAAGTTCTCCAGCTTCAGCTCAACTCACAGCTTCTCCAAGCA TCACCCTGGGAGTTTCCTGAGGGTTTTCTCATAAATGAGGGCTGCACATTGCCTGTTCTGCTTCGAAGTATTCAATACCGCTCAGTATTTTAAATGAAGT GATTCTAAGATTTGGTTTGGGATCAATAGGAAAGCATATGCAGCCAACCAAGATGCAAATGTTTTGAAATGATATGACCAAAATTTTAAGTAGGAAAGTC ACCCAAACACTTCTGCTTTCACTTAAGTGTCTGGCCCGCAATACTGTAGGAACAAGCATGATCTTGTTACTGTGATATTTTAAATATCCACAGTACTCAC TTTTTCCAAATGATCCTAGTAATTGCCTAGAAATATCTTTCTCTTACCTGTTATTTATCAATTTTTCCCAGTATTTTTATACGGAAAAAATTGTATTGAA AACACTTAGTATGCAGTTGATAAGAGGAATTTGGTATAATTATGGTGGGTGATTATTTTTTATACTGTATGTGCCAAAGCTTTACTACTGTGGAAAGACA ACTGTTTTAATAAAAGATTTACATTCCACAACTTGAAGTTCATCTATTTGATATAAGACACCTTCGGGGGAAATAATTCCTGTGAATATTCTTTTTCAAT TCAGCAAACATTTGAAAATCTATGATGTGCAAGTCTAATTGTTGATTTCAGTACAAGATTTTCTAAATCAGTTGCTACAAAAACTGATTGGTTTTTGTCA CTTCATCTCTTCACTAATGGAGATAGCTTTACACTTTCTGCTTTAATAGATTTAAGTGGACCCCAATATTTATTAAAATTGCTAGTTTACCGTTCAGAAG TATAATAGAAATAATCTTTAGTTGCTCTTTTCTAACCATTGTAATTCTTCCCTTCTTCCCTCCACCTTTCCTTCATTGAATAAACCTCTGTTCAAAGAGA TTGCCTGCAAGGGAAATAAAAATGACTAAGATATTAAAAGTATTTGAATAGTATAATATGGAGGAGTTTTATCTTAGGGAAACCCCATGGTATGATAACC CCCATCTAACATGTCTTACTTTGGGTCAGCTGACACTTTTGGCATGGCTTGATAAACTCCCAGCTAAACAGTTTGTTTACTCCTGATCTGTAAAGGTCAT TTCTTTTTCAATTTAACATTGAGGAAACAAACTTTGGGATTAAATTTGACATTCAGGCCAGGCGCAGTGGCTCACACCTCTAATCCCAGCACTTTGGGAG GCTGAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCTTGTCTCTATTAAAAATACAAATGTTACCAGGCATG GCAGTGGGCGTCTTTGGTCCCGGCTACTCAGAAGGCTGAGGTAGGAGAATGGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCTGAGATTGTGCCATTG AACTCCAGCATGGGGGACAGAGCAAGACTCCATCCCAAAAAACATAAATAAATAAATGTGACATTCAGAATAGTAAATAGTGGAAATGGAAATAATTATT AGTAAAAAATTAGTAGTTCATAATAAACAAGACATGCAAAGCACTTTTTAAATATACTAATGTACAATGAAAGAAGGTATTTCAATAAACACCTGGCAAA GAATATTAAAACTAAATACAGAAAGATACTTCCTCATGTTCATTTGAAAAAAAAAAATACTAACTCCCATTTGAATTGATTTACAGTTTATAAAATGCTT TGACATTTAGCTATCTCATTTAGGGGAGGTTTTAGAGCTTAATTTTACAGGGCATGAAGCTCAGATGAGGTTTCCTTAGCGAAATACAGACCCAGCCCCT GGACTTCTATTTATTACTGATCTTTAAGCTTTATCAGCCCAATAGTCACCAAGAGAGCTGCTCTGTATGTTTTTTAAAAATCACAGAAAGTACAAAATAA AGGTGATATTAAACGACTGTC

FN1.u.f.55 (forward primer)
FN1.u.r.66 (reverse primer)
Single exon skipping

Frame 0

RGGDSPAGLSSPAPRASRGAGGDRPI*APAPGA RTPAPAVLHRGRRGNPRREREEGTCSHNFSGPLH PFCPSTRPLPHPLAPTFLEATTPGRH*KGFFPQ VAKGSKLGGNLPPGAGVSPPPSQHA*GSGARAA AAGRPVPGDSGALHGSLEEQEAGSANGSAPVPGG CQSKQARLL*QWKTLSDKSTVGADLPRQCVGLY LLWRKPRF*LRE*T*S*RDLL*QVHWEHLPSG* HL*AS*RLHDLGLYLHRGWARENKLYHRKPLP*R GSVLQDW*HLEETT*DWWLHVRVCVSW*WKRRM DLQAHS*EVF*SCCWDFLCGRRNVGEALPRLDD GRLYLPGRRQRTHHLHF*K*MQRSGHKDIL*NWR HLEQEG*SRKPAPVHLHRQRPRRVEV*EAHLCA DHIERIWPLHRCSCSCLPTAASPPASSLWPLCH RQWCGLLCGDAVAEDTRK*ANALHVPGQRSQLPR DSCNPDLRWQLKWRAMCLTIHLQWQDVLLLHHR RATGRTSLVQHNFEL*AGPEILFLHRPHCFGSD SRRKFQWCLVPLPLPIQQPQLH*LHF*GQKRQHE VVWDHTEL*CRPEVWVLPHGCPRGNLHNQ*RGH VPHWRSVG*AA*HGSHDEVHVCWEWSWGMDMHC LLAASRSVHC**HHLQCERHIPQAS*RGAHAELY MLRSGSGQVEV*SRRPMPGFRDWDVLSNWRFMG EVCAWCQIPVLLLWPWHWGVALPTFTDLSKLKW SCRSIYH*DSESAQLPPHPVECTTAISHFQVHSQ VET*KFCRPLEGSYHTRPLKLLHHQRPEAWCGI RGPAHQHPAVRPPRSDSL*LHHHQHQHTCDQQH RDRRDDSLFSSCGHF*ICDRNHSQ*LCGLLGLSF RHRVGIPGGI*AE*GGR*ATVPGSSKHSHFCEH P*PASWPKIHCKCLSDI*GWGAEFDPVYFTNNS A*CPS*HDCGPS**HLNCCSLEQTPGSHHRVQNS LFAISRR*QHRTQPS*NCKLRHPQ*LATWCSV* HHYLCCGRKSRKYTCCHSTRNHWHPTLRYSALS QGPAVCGSDRREGHHHVDTA*ECSDRLPCGCDPR QPAWRARAEAAHQQEHLCRSHRAVPWGHLLLQS LCSEPWEGEQASDCSTDNQTGCSH*PPVCQ*N* FYCPGEMDSTSGPDNRIPTDRGPYPKRTAQAVQC GSLCLQVPTEESAACI*VHRIPRGHKGQPREPQ SHWSLYHTAAWELYSTLQHRGD*DHHCDHMDAC SKNWF*AGCTTKPGRRGTTRSDFRLRKHRCVRLD SRSRIRLHHPSPERWTGKRCANCKQSGDTIVST NKLASGGKP*HWSAHSLLGEEHHPRHYWL*NYH NPYKRPAGKFFGRSGPC*SELLHF**PESRPGVQ CQCLHCQG*QGKCPYL*YHHPSCSSSH*PAIHQ HWSRHHACHLGSTPIH*FNQLPGALLTCEK*GR CCRVVNFSFRQCSGLNKSPAWYRICSECLQCLRT T*EHTS*RKTENRS*FPNWH*LF*YYCQLFYCA LDCSSSHHHWLQDPPSSRALQWETSRRSGAPLS EFHHPHQPHSRHRVCGQHRCS*WQRGKSLIDWPT INSF*CSEGPGSCCCDPHQPTDQLGCSCCHSEI LQDHLRRDRRK*PCPGVHCAWEQVYSYHQRP*T WS*LYHHCVCCHWPWRQPRKQQANFH*LPNRN*Q TIPDASDRCSGQQH*CQVAAFKFPCYWLQSNHH SQKWTRTNKN*NCRSRSNRNDY*RLAAHSGVCG *CLCSESKRRESASGSDCSNQH*SP*RTGIH*CG CRFHQNCLGKPTGASFQVQGDLLEP*GWNP*AI PCT*W*RRHCRAARPQTGF*VHSQCGCLAR*YG EPAPDWNPVHSYSCTN*PEVHSGHTHKPERPVDT TQCSAHWISSAGDPQGEDRTNERNQPCS*QLIR GCIRTYGGHQI*SECLCS*GHFDKQTSSGSCHH SGECQPTKKGSCDRCY*DHHHH*LENQD*DDHWL PS*CRSSQWPDSNPENHQARCQKLHHHRFTTRH *LQDLPVHLE*QCSELPCGHRRLHCH*CTIQPA FPGHHTQFLAGIMAAATCQDYRLHHQV*EAWVSS QRSGPSAPPWCHRGYYYWPGTGNRIYNLCHCPE E*SEERAPDWKEKDRRASPTGNPSTPQSSWTRD LGCSFHSSKDPFRHPPWV*HWKWYSASWHFWSAT QCWATNDL*GTWF*ADHTAHNGHPHKA*AKTIP AECRTRSSLSDNHLMGPIPGHF*VHHFMSSCWH **RTLTVQGSWNFYQCHSDRPHQRCHLQRHSGGT ERPAEA*GSGRGCYRGQLCQRRLEPTYG*LVL* PLHSFPLCRWR*VGTNV*IRL*TVVPVLRLWKW SFQM*FI*MVP*QWCELQDWREVGPSGRKWPDDE LHMSWERKRRIQV*PS*GNVL**WEDIPRRRTV AEGISRCHLLLHMLWRPAGLAL*QLPQTWG*TQ SRRHYWPVLQPVFSEIPSENKH*C*LPN*VLHAF RCTG*QRRFPRVNHLSNPEEQACLSAKIHLNWS DVSRPSLEFFFLS*ALCSGGSSPASAQLTASPS ITLGVS*GFSHK*GLHIACSASKYSIPLSILNEV ILRFGLGSIGKHMQPTKMQMF*NDMTKILSRKV TQTLLLSLKCLARNTVGTSMILLL*YFKYPQYS LFPNDPSNCLEISFSYLLFINFSQYFYTEKIVLK TLSMQLIRGIWYNYGG*LFFILYVPKLYYCGKT TVLIKDLHSTT*SSSI*YKTPSGEIIPVNILFQ FSKHLKIYDVQV*LLISVQDFLNQLLQKLIGFCH FISSLMEIALHFLL**I*VDPNIY*NC*FTVQK YNRNNL*LLFSNHCNSSLLPSTFPSLNKPLFKE IACKGNKND*DIKSI*IV*YGGVLS*GNPMV**P PSNMSYFGSADTFGMA**TPS*TVCLLLICKGH FFFNLTLRKQTLGLNLTFRPGAVAHTSNPSTLG G*GRWIT*GQEFETSLANMVKPCLY*KYKCYQAW QWASLVPATQKAEVGEWLEPRRRRLQ*AEIVPL NSSMGDRARLHPKKHK*INVTFRIVNSGNGNNY **KISSS**TRHAKHFLNILMYNERRYFNKHLAK NIKTKYRKILPHVHLKKKNTNSHLN*FTVYKML *HLAISFRGGFRA*FYRA*SSDEVSLAKYRPSP WTSIYY*SLSFISPIVTKRAALYVF*KSQKVQNK GDIKRL

Frame 1

GAGTARRVSPPPRPGPPEGREGTVPYKPRLPAL GRPRRLCCTGGGEGTPGASGKRGPAATTSLVLC IPSVPPPVPFPTLWPPPSWRRQPPGGIRRDFSRR LRREANLVATCLPVRASLPHRLNMLRGPGPGLL LLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPV AVSQSKPGCYDNGKHYQINQQWERTYLGNALVCT CYGGSRGFNCESKPEAEETCFDKYTGNTYRVGD TYERPKDSMIWDCTCIGAGRGRISCTIANRCHE GGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEW TCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMM VDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIG DTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQ TTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVT DSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQ ETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTE GRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQT RGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNM KWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVM YRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIA YSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNC TCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWE KYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSG PVEVFITETPSQPNSHPIQWNAPQPSHISKYIL RWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVY EGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNT VTGETTPFSPLVATSESVTEITASSFVVSWVSA SDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNI PDLLPGRKYIVNVYQISEDGEQSLILSTSQTTA PDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRI VYSPSVEGSSTELNLPETANSVTLSDLQPGVQYN ITIYAVEENQESTPVVIQQETTGTPRSDTVPSP RDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIP VNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKV FAVSHGRESKPLTAQQTTKLDAPTNLQFVNETD STVLVRWTPPRAQITGYRLTVGLTRRGQPRQYN VGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPK ATGVFTTLQPGSSIPPYNTEVTETTIVITWTPA PRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGL TPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPP TNLHLEANPDTGVLTVSWERSTTPDITGYRITT TPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEY NVSVYTVKDDKESVPISDTIIPAVPPPTDLRFTN IGPDTMRVTWAPPPSIDLTNFLVRYSPVKNEED VAELSISPSDNAVVLTNLLPGTEYVVSVSSVYE QHESTPLRGRQKTGLDSPTGIDFSDITANSFTVH WIAPRATITGYRIRHHPEHFSGRPREDRVPHSR NSITLTNLTPGTEYVVSIVALNGREESPLLIGQ QSTVSDVPRDLEVVAATPTSLLISWDAPAVTVRY YRITYGETGGNSPVQEFTVPGSKSTATISGLKP GVDYTITVYAVTGRGDSPASSKPISINYRTEID KPSQMQVTDVQDNSISVKWLPSSSPVTGYRVTTT PKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVV SVYAQNPSGESQPLVQTAVTNIDRPKGLAFTDV DVDSIKIAWESPQGQVSRYRVTYSSPEDGIHELF PAPDGEEDTAELQGLRPGSEYTVSVVALHDDME SQPLIGTQSTAIPAPTDLKFTQVTPTSLSAQWT PPNVQLTGYRVRVTPKEKTGPMKEINLAPDSSSV VVSGLMVATKYEVSVYALKDTLTSRPAQGVVTT LENVSPPRRARVTDATETTITISWRTKTETITG FQVDAVPANGQTPIQRTIKPDVRSYTITGLQPGT DYKIYLYTLNDNARSSPVVIDASTAIDAPSNLR FLATTPNSLLVSWQPPRARITGYIIKYEKPGSP PREVVPRPRPGVTEATITGLEPGTEYTIYVIALK NNQKSEPLIGRKKTDELPQLVTLPHPNLHGPEI LDVPSTVQKTPFVTHPGYDTGNGIQLPGTSGQQ PSVGQQMIFEEHGFRRTTPPTTATPIRHRPRPYP PNVGQEALSQTTISWAPFQDTSEYIISCHPVGT DEEPLQFRVPGTSTSATLTGLTRGATYNVIVEA LKDQQRHKVREEVVTVGNSVNEGLNQPTDDSCFD PYTVSHYAVGDEWERMSESGFKLLCQCLGFGSG HFRCDSSRWCHDNGVNYKIGEKWDRQGENGQMM SCTCLGNGKGEFKCDPHEATCYDDGKTYHVGEQW QKEYLGAICSCTCFGGQRGWRCDNCRRPGGEPS PEGTTGQSYNQYSQRYHQRTNTNVNCPIECFMP LDVQADREDSRE*IIFPIQRNKHVSLPRSI*TGV MLADPA*SSSFFLKPFALEEVLQLQLNSQLLQA SPWEFPEGFLINEGCTLPVLLRSIQYRSVF*MK *F*DLVWDQ*ESICSQPRCKCFEMI*PKF*VGKS PKHFCFHLSVWPAIL*EQA*SCYCDILNIHSTH FFQMILVIA*KYLSLTCYLSIFPSIFIRKKLY* KHLVCS**EEFGIIMVGDYFLYCMCQSFTTVERQ LF**KIYIPQLEVHLFDIRHLRGK*FL*IFFFN SANI*KSMMCKSNC*FQYKIF*ISCYKN*LVFV TSSLH*WR*LYTFCFNRFKWTPIFIKIASLPFRS IIEIIFSCSFLTIVILPFFPPPFLH*INLCSKR LPAREIKMTKILKVFE*YNMEEFYLRETPWYDN PHLTCLTLGQLTLLAWLDKLPAKQFVYS*SVKVI SFSI*H*GNKLWD*I*HSGQAQWLTPLIPALWE AEAGGSPEVRSLRPAWPTW*NLVSIKNTNVTRH GSGRLWSRLLRRLR*ENGLNPEGGGCSELRLCH* TPAWGTEQDSIPKNINK*M*HSE**IVEMEIII SKKLVVHNKQDMQSTF*IY*CTMKEGISINTWQ RILKLNTERYFLMFI*KKKILTPI*IDLQFIKCF DI*LSHLGEVLELNFTGHEAQMRFP*RNTDPAP GLLFITDL*ALSAQ*SPRELLCMFFKNHRKYKI KVILNDC

Frame 2

GRGQPGGSLLPRAPGLQRGGRGPSHISPGSRRS DARAGCAAQGEEREPQARAGRGDLQPQLLWSSA SLLSLHPSPSPPSGPHLLGGDNPREALEGIFPA GCEGKQTWWQLASRCGRLSPTVSTCLGVRGPGCC CWPSSAWGQRCPPREPRRARGRLSKWFSPSPRW LSVKASPVVMTMENTIR*INSGSGPT*AMRWFV LVMEEAEVLTARVNLKLKRLALTSTLGTLTEWVT LMSVLKTP*SGTVPASGLGEGE*AVPSQTAAMK GVSPTRLVTPGGDHMRLVVTC*SVCVLVMEKEN GPASP*LRSVLIMLLGLPMWSEKRGRSPTKAG*W *IVLAWEKAADASLALLEIDATIRTQGHPIELE TPGARRIIEETCSSASAQATAEESGSVRGTPLC RPHRADLAPSPMFVQLFTNRSLTPSLLPMATVSQ TVVWSTLWGCSG*RHKEISKCFARAWATESAAK RQL*PRLTVATQMESHVSYHSPTMAGRSTPAPQ KGDRTDIFGAAQLRIMSRTRNTLSAQTTLFWFRL EEEIPMVPCATSPSYTTTTITLIALLRAEETT* SGVGPHRTMMPTRSLGSAPWLPTRKSAQPMKGS CTALEISGISSMTWVT**GARVLGMVVGNGHALP TRSFEISALLMTSLTM*TTHSTSVMKRGTC*TV HASVRVGAGGSVIPSTNARIQRLGRFIKLEIHG RSMCMVSDTSATAMAVALGSGIANLYRPIQAQVV LSKYLSLRLRVSPTPTPSSGMHHSHLTFPSTFS GGDLKIL*AVGRKLPYQAT*TPTPSKA*SLVWY TRASSSASSSTATKK*LALTSPPPAPAHL*PATP *QERRLPFLLLWPLLNL*PKSQPVALWSPGSQL PTPCRDSGWNMS*VRREMSHSTWIFQAQPLL*T SLTCFLAENTL*MSIRYLRMGSRV*SCLLHKQQR LMPLLTRLWTKLMTPQLLFAGADPRLPSQGTE* SIRHQ*KVAAQNSTFLKLQTPSPSVTCNLVFSI TSLSMLWKKIKKVHLLSFNKKPLAPHAQIQCPLP GTCSLWK*QT*RSPSCGHRLRVQ*PATVWM*SP STCLASTGRGCPSAGTPLQKSPGCPLGSPITSK SLQ*AMGGRASL*LLNRQPNWMLPLTSSLSMKLI LLSW*DGLHLGPR*QDTD*PWALPEEDSPGSTM WVPLSPSTH*GICSLHLSTPYPSWP*RATKRAP KPLESLPHCSLGALFHLTTPR*LRPPL*SHGRLL QELVLSWVYDQAREERHHEK*LQTQEASLCPA* LQE*NTSTPSKS*EMDRKEMRQL*TKW*HHCLH QQTCIWRQTLTLECSQSPGRGAPPQTLLVIELPQ PLQTASREILWKKWSMLIRAPALLIT*VPAWST MSVFTLSRMTRKVSLSLIPSSQLFLLPLTCDSP TLVQTPCVSPGLHPHPLI*PTSWCVTHL*KMRKM LQSCQFLLQTMQWS*QISCLVQNM**VSPVSTN NMRAHLLEEDRKQVLIPQLALTFLILLPTLLLC TGLLLEPPSLATGSAIIPSTSVGDLEKIGCPTLG IPSPSPTSLQAQSMWSASLLLMAERKVPY*LAN NQQFLMFRGTWKLLLRPPPAY*SAGMLLLSQ*D ITGSLTERQEEIALSRSSLCLGASLQLPSAALNL ELIIPSLCMLSLAVETAPQAASQFPLITEQKLT NHPRCK*PMFRTTALVSSGCLQVPLLLVTE*PP LPKMDQDQQKLKLQVQIKQK*LLKACSPQWSMWL VSMLRIQAERVSLWFRLQ*PTLIALKDWHSLMW MSIPSKLLGKAHRGKFPGTG*PTRALRMESMSY SLHLMVKKTLQSCKASDRVLSTQSVWLPCTMIWR ASP*LEPSPQLFLHQLT*SSLRSHPQA*APSGH HPMFSSLDIECG*PPRRRPDQ*KKSTLLLTAHP WLYQDLWWPPNMK*VSMLLRTL*QADQLRELSPL WRMSAHQEGLV*QMLLRPPSPLAGEPRLRRSLA SKLMPFQPMARLQSREPSSQMSEATPSQVYNQA LTTRSTCTP*MTMLGAPLWSSTPPLPLMHHPTCV SWPPHPIPCWYHGSRHVPGLPATSSSMRSLGLL PEKWSLGPALVSQRLLLLAWNREPNIQFMSLP* RIIRRASP*LEGKRQTSFPNW*PFHTPIFMDQRS WMFLPQFKRPLSSPTLGMTLEMVFSFLALLVSN PVLGNK*SLRNMVLGGPHRPQRPPP*GIGQDHT RRM*DKKLSLRQPSHGPHSRTLLSTSFHVILLAL MKNPYSSGFLELLPVPL*QASPEVPPTTS*WRH *KTSRGIRFGKRLLPWATLSTKA*TNLRMTRAL TPTQFPIMPLEMSGNECLNQALNCCASA*ALEVV ISDVIHLDGAMTMV*TTRLERSGTVREKMAR** AAHVLGTEKENSSVTLMRQRVMMMGRHTT*ENS GRRNISVPFAPAHALEASGAGAVTTAADLGVNPV PKALLASPTTSILRDTIREQTLMLIAQLSASCL *MYRLTEKIPESKSSFQSRGTSMSLCQDPSKLE *C*QTQLRVLLSFLSPLLWRKFSSFSSTHSFSKH HPGSFLRVFS*MRAAHCLFCFEVFNTAQYFK*S DSKIWFGINRKAYAANQDANVLK*YDQNFK*ES HPNTSAFT*VSGPQYCRNKHDLVTVIF*ISTVLT FSK*S**LPRNIFLLPVIYQFFPVFLYGKNCIE NT*YAVDKRNLV*LWWVIIFYTVCAKALLLWKD NCFNKRFTFHNLKFIYLI*DTFGGNNSCEYSFSI QQTFENL*CASLIVDFSTRFSKSVATKTDWFLS LHLFTNGDSFTLSALIDLSGPQYLLKLLVYRSE V**K*SLVALF*PL*FFPSSLHLSFIE*TSVQRD CLQGK*K*LRY*KYLNSIIWRSFILGKPHGMIT PI*HVLLWVS*HFWHGLINSQLNSLFTPDL*RS FLFQFNIEETNFGIKFDIQARRSGSHL*SQHFGR LRQVDHLRSGV*DQPGQHGETLSLLKIQMLPGM AVGVFGPGYSEG*GRRMA*TQKAEVAVS*DCAI ELQHGGQSKTPSQKT*INKCDIQNSK*WKWK*LL VKN**FIINKTCKALFKYTNVQ*KKVFQ*TPGK EY*N*IQKDTSSCSFEKKKY*LPFELIYSL*NA LTFSYLI*GRF*SLILQGMKLR*GFLSEIQTQPL DFYLLLIFKLYQPNSHQESCSVCFLKITESTK* R*Y*TTV

Sequence FN1.bAug05

CGGGGCGGGGACAGCCCGGCGGGTCTCTCCTCCCCCGCGCCCCGGGCCTCCAGAGGGGCGGGAGGGGACCGTCCCATATAAGCCCCGGCTCCCGGCGCTC GGACGCCCGCGCCGGCTGTGCTGCACAGGGGGAGGAGAGGGAACCCCAGGCGCGAGCGGGAAGAGGGGACCTGCAGCCACAACTTCTCTGGTCCTCTGCA TCCCTTCTGTCCCTCCACCCGTCCCCTTCCCCACCCTCTGGCCCCCACCTTCTTGGAGGCGACAACCCCCGGGAGGCATTAGAAGGGATTTTTCCCGCAG GTTGCGAAGGGAAGCAAACTTGGTGGCAACTTGCCTCCCGGTGCGGGCGTCTCTCCCCCACCGTCTCAACATGCTTAGGGGTCCGGGGCCCGGGCTGCTG CTGCTGGCCGTCCAGTGCCTGGGGACAGCGGTGCCCTCCACGGGAGCCTCGAAGAGCAAGAGGCAGGCTCAGCAAATGGTTCAGCCCCAGTCCCCGGTGG CTGTCAGTCAAAGCAAGCCCGGTTGTTATGACAATGGAAAACACTATCAGATAAATCAACAGTGGGAGCGGACCTACCTAGGCAATGCGTTGGTTTGTAC TTGTTATGGAGGAAGCCGAGGTTTTAACTGCGAGAGTAAACCTGAAGCTGAAGAGACTTGCTTTGACAAGTACACTGGGAACACTTACCGAGTGGGTGAC ACTTATGAGCGTCCTAAAGACTCCATGATCTGGGACTGTACCTGCATCGGGGCTGGGCGAGGGAGAATAAGCTGTACCATCGCAAACCGCTGCCATGAAG GGGGTCAGTCCTACAAGATTGGTGACACCTGGAGGAGACCACATGAGACTGGTGGTTACATGTTAGAGTGTGTGTGTCTTGGTAATGGAAAAGGAGAATG GACCTGCAAGCCCATAGCTGAGAAGTGTTTTGATCATGCTGCTGGGACTTCCTATGTGGTCGGAGAAACGTGGGAGAAGCCCTACCAAGGCTGGATGATG GTAGATTGTACTTGCCTGGGAGAAGGCAGCGGACGCATCACTTGCACTTCTAGAAATAGATGCAACGATCAGGACACAAGGACATCCTATAGAATTGGAG ACACCTGGAGCAAGAAGGATAATCGAGGAAACCTGCTCCAGTGCATCTGCACAGGCAACGGCCGAGGAGAGTGGAAGTGTGAGAGGCACACCTCTGTGCA GACCACATCGAGCGGATCTGGCCCCTTCACCGATGTTCGTGCAGCTGTTTACCAACCGCAGCCTCACCCCCAGCCTCCTCCCTATGGCCACTGTGTCACA GACAGTGGTGTGGTCTACTCTGTGGGGATGCAGTGGCTGAAGACACAAGGAAATAAGCAAATGCTTTGCACGTGCCTGGGCAACGGAGTCAGCTGCCAAG AGACAGCTGTAACCCAGACTTACGGTGGCAACTCAAATGGAGAGCCATGTGTCTTACCATTCACCTACAATGGCAGGACGTTCTACTCCTGCACCACAGA AGGGCGACAGGACGGACATCTTTGGTGCAGCACAACTTCGAATTATGAGCAGGACCAGAAATACTCTTTCTGCACAGACCACACTGTTTTGGTTCAGACT CGAGGAGGAAATTCCAATGGTGCCTTGTGCCACTTCCCCTTCCTATACAACAACCACAATTACACTGATTGCACTTCTGAGGGCAGAAGAGACAACATGA AGTGGTGTGGGACCACACAGAACTATGATGCCGACCAGAAGTTTGGGTTCTGCCCCATGGCTGCCCACGAGGAAATCTGCACAACCAATGAAGGGGTCAT GTACCGCATTGGAGATCAGTGGGATAAGCAGCATGACATGGGTCACATGATGAGGTGCACGTGTGTTGGGAATGGTCGTGGGGAATGGACATGCATTGCC TACTCGCAGCTTCGAGATCAGTGCATTGTTGATGACATCACTTACAATGTGAACGACACATTCCACAAGCGTCATGAAGAGGGGCACATGCTGAACTGTA CATGCTTCGGTCAGGGTCGGGGCAGGTGGAAGTGTGATCCCGTCGACCAATGCCAGGATTCAGAGACTGGGACGTTTTATCAAATTGGAGATTCATGGGA GAAGTATGTGCATGGTGTCAGATACCAGTGCTACTGCTATGGCCGTGGCATTGGGGAGTGGCATTGCCAACCTTTACAGACCTATCCAAGCTCAAGTGGT CCTGTCGAAGTATTTATCACTGAGACTCCGAGTCAGCCCAACTCCCACCCCATCCAGTGGAATGCACCACAGCCATCTCACATTTCCAAGTACATTCTCA GGTGGAGACCTAAAAATTCTGTAGGCCGTTGGAAGGAAGCTACCATACCAGGCCACTTAAACTCCTACACCATCAAAGGCCTGAAGCCTGGTGTGGTATA CGAGGGCCAGCTCATCAGCATCCAGCAGTACGGCCACCAAGAAGTGACTCGCTTTGACTTCACCACCACCAGCACCAGCACACCTGTGACCAGCAACACC GTGACAGGAGAGACGACTCCCTTTTCTCCTCTTGTGGCCACTTCTGAATCTGTGACCGAAATCACAGCCAGTAGCTTTGTGGTCTCCTGGGTCTCAGCTT CCGACACCGTGTCGGGATTCCGGGTGGAATATGAGCTGAGTGAGGAGGGAGATGAGCCACAGTACCTGGATCTTCCAAGCACAGCCACTTCTGTGAACAT CCCTGACCTGCTTCCTGGCCGAAAATACATTGTAAATGTCTATCAGATATCTGAGGATGGGGAGCAGAGTTTGATCCTGTCTACTTCACAAACAACAGCG CCTGATGCCCCTCCTGACACGACTGTGGACCAAGTTGATGACACCTCAATTGTTGTTCGCTGGAGCAGACCCCAGGCTCCCATCACAGGGTACAGAATAG TCTATTCGCCATCAGTAGAAGGTAGCAGCACAGAACTCAACCTTCCTGAAACTGCAAACTCCGTCACCCTCAGTGACTTGCAACCTGGTGTTCAGTATAA CATCACTATCTATGCTGTGGAAGAAAATCAAGAAAGTACACCTGTTGTCATTCAACAAGAAACCACTGGCACCCCACGCTCAGATACAGTGCCCTCTCCC AGGGACCTGCAGTTTGTGGAAGTGACAGACGTGAAGGTCACCATCATGTGGACACCGCCTGAGAGTGCAGTGACCGGCTACCGTGTGGATGTGATCCCCG TCAACCTGCCTGGCGAGCACGGGCAGAGGCTGCCCATCAGCAGGAACACCTTTGCAGAAGTCACCGGGCTGTCCCCTGGGGTCACCTATTACTTCAAAGT CTTTGCAGTGAGCCATGGGAGGGAGAGCAAGCCTCTGACTGCTCAACAGACAACCAAACTGGATGCTCCCACTAACCTCCAGTTTGTCAATGAAACTGAT TCTACTGTCCTGGTGAGATGGACTCCACCTCGGGCCCAGATAACAGGATACCGACTGACCGTGGGCCTTACCCGAAGAGGACAGCCCAGGCAGTACAATG TGGGTCCCTCTGTCTCCAAGTACCCACTGAGGAATCTGCAGCCTGCATCTGAGTACACCGTATCCCTCGTGGCCATAAAGGGCAACCAAGAGAGCCCCAA AGCCACTGGAGTCTTTACCACACTGCAGCCTGGGAGCTCTATTCCACCTTACAACACCGAGGTGACTGAGACCACCATTGTGATCACATGGACGCCTGCT CCAAGAATTGGTTTTAAGCTGGGTGTACGACCAAGCCAGGGAGGAGAGGCACCACGAGAAGTGACTTCAGACTCAGGAAGCATCGTTGTGTCCGGCTTGA CTCCAGGAGTAGAATACGTCTACACCATCCAAGTCCTGAGAGATGGACAGGAAAGAGATGCGCCAATTGTAAACAAAGTGGTGACACCATTGTCTCCACC AACAAACTTGCATCTGGAGGCAAACCCTGACACTGGAGTGCTCACAGTCTCCTGGGAGAGGAGCACCACCCCAGACATTACTGGTTATAGAATTACCACA ACCCCTACAAACGGCCAGCAGGGAAATTCTTTGGAAGAAGTGGTCCATGCTGATCAGAGCTCCTGCACTTTTGATAACCTGAGTCCCGGCCTGGAGTACA ATGTCAGTGTTTACACTGTCAAGGATGACAAGGAAAGTGTCCCTATCTCTGATACCATCATCCCAGAGGTGCCCCAACTCACTGACCTAAGCTTTGTTGA TATAACCGATTCAAGCATCGGCCTGAGGTGGACCCCGCTAAACTCTTCCACCATTATTGGGTACCGCATCACAGTAGTTGCGGCAGGAGAAGGTATCCCT ATTTTTGAAGATTTTGTGGACTCCTCAGTAGGATACTACACAGTCACAGGGCTGGAGCCGGGCATTGACTATGATATCAGCGTTATCACTCTCATTAATG GCGGCGAGAGTGCCCCTACTACACTGACACAACAAACGGCTGTTCCTCCTCCCACTGACCTGCGATTCACCAACATTGGTCCAGACACCATGCGTGTCAC CTGGGCTCCACCCCCATCCATTGATTTAACCAACTTCCTGGTGCGTTACTCACCTGTGAAAAATGAGGAAGATGTTGCAGAGTTGTCAATTTCTCCTTCA GACAATGCAGTGGTCTTAACAAATCTCCTGCCTGGTACAGAATATGTAGTGAGTGTCTCCAGTGTCTACGAACAACATGAGAGCACACCTCTTAGAGGAA GACAGAAAACAGGTCTTGATTCCCCAACTGGCATTGACTTTTCTGATATTACTGCCAACTCTTTTACTGTGCACTGGATTGCTCCTCGAGCCACCATCAC TGGCTACAGGATCCGCCATCATCCCGAGCACTTCAGTGGGAGACCTCGAGAAGATCGGGTGCCCCACTCTCGGAATTCCATCACCCTCACCAACCTCACT CCAGGCACAGAGTATGTGGTCAGCATCGTTGCTCTTAATGGCAGAGAGGAAAGTCCCTTATTGATTGGCCAACAATCAACAGTTTCTGATGTTCCGAGGG ACCTGGAAGTTGTTGCTGCGACCCCCACCAGCCTACTGATCAGCTGGGATGCTCCTGCTGTCACAGTGAGATATTACAGGATCACTTACGGAGAGACAGG AGGAAATAGCCCTGTCCAGGAGTTCACTGTGCCTGGGAGCAAGTCTACAGCTACCATCAGCGGCCTTAAACCTGGAGTTGATTATACCATCACTGTGTAT GCTGTCACTGGCCGTGGAGACAGCCCCGCAAGCAGCAAGCCAATTTCCATTAATTACCGAACAGAAATTGACAAACCATCCCAGATGCAAGTGACCGATG TTCAGGACAACAGCATTAGTGTCAAGTGGCTGCCTTCAAGTTCCCCTGTTACTGGTTACAGAGTAACCACCACTCCCAAAAATGGACCAGGACCAACAAA AACTAAAACTGCAGGTCCAGATCAAACAGAAATGACTATTGAAGGCTTGCAGCCCACAGTGGAGTATGTGGTTAGTGTCTATGCTCAGAATCCAAGCGGA GAGAGTCAGCCTCTGGTTCAGACTGCAGTAACCAACATTGATCGCCCTAAAGGACTGGCATTCACTGATGTGGATGTCGATTCCATCAAAATTGCTTGGG AAAGCCCACAGGGGCAAGTTTCCAGGTACAGGGTGACCTACTCGAGCCCTGAGGATGGAATCCATGAGCTATTCCCTGCACCTGATGGTGAAGAAGACAC TGCAGAGCTGCAAGGCCTCAGACCGGGTTCTGAGTACACAGTCAGTGTGGTTGCCTTGCACGATGATATGGAGAGCCAGCCCCTGATTGGAACCCAGTCC ACAGCTATTCCTGCACCAACTGACCTGAAGTTCACTCAGGTCACACCCACAAGCCTGAGCGCCCAGTGGACACCACCCAATGTTCAGCTCACTGGATATC GAGTGCGGGTGACCCCCAAGGAGAAGACCGGACCAATGAAAGAAATCAACCTTGCTCCTGACAGCTCATCCGTGGTTGTATCAGGACTTATGGTGGCCAC CAAATATGAAGTGAGTGTCTATGCTCTTAAGGACACTTTGACAAGCAGACCAGCTCAGGGAGTTGTCACCACTCTGGAGAATGTCAGCCCACCAAGAAGG GCTCGTGTGACAGATGCTACTGAGACCACCATCACCATTAGCTGGAGAACCAAGACTGAGACGATCACTGGCTTCCAAGTTGATGCCGTTCCAGCCAATG GCCAGACTCCAATCCAGAGAACCATCAAGCCAGATGTCAGAAGCTACACCATCACAGGTTTACAACCAGGCACTGACTACAAGATCTACCTGTACACCTT GAATGACAATGCTCGGAGCTCCCCTGTGGTCATCGACGCCTCCACTGCCATTGATGCACCATCCAACCTGCGTTTCCTGGCCACCACACCCAATTCCTTG CTGGTATCATGGCAGCCGCCACGTGCCAGGATTACCGGCTACATCATCAAGTATGAGAAGCCTGGGTCTCCTCCCAGAGAAGTGGTCCCTCGGCCCCGCC CTGGTGTCACAGAGGCTACTATTACTGGCCTGGAACCGGGAACCGAATATACAATTTATGTCATTGCCCTGAAGAATAATCAGAAGAGCGAGCCCCTGAT TGGAAGGAAAAAGACAGACGAGCTTCCCCAACTGGTAACCCTTCCACACCCCAATCTTCATGGACCAGAGATCTTGGATGTTCCTTCCACAGTTCAAAAG ACCCCTTTCGTCACCCACCCTGGGTATGACACTGGAAATGGTATTCAGCTTCCTGGCACTTCTGGTCAGCAACCCAGTGTTGGGCAACAAATGATCTTTG AGGAACATGGTTTTAGGCGGACCACACCGCCCACAACGGCCACCCCCATAAGGCATAGGCCAAGACCATACCCGCCGAATGTAGGACAAGAAGCTCTCTC TCAGACAACCATCTCATGGGCCCCATTCCAGGACACTTCTGAGTACATCATTTCATGTCATCCTGTTGGCACTGATGAAGAACCCTTACAGTTCAGGGTT CCTGGAACTTCTACCAGTGCCACTCTGACAGGCCTCACCAGAGGTGCCACCTACAACGTCATAGTGGAGGCACTGAAAGACCAGCAGAGGCATAAGGTTC GGGAAGAGGTTGTTACCGTGGGCAACTCTGTCAACGAAGGCTTGAACCAACCTACGGATGACTCGTGCTTTGACCCCTACACAGTTTCCCATTATGCCGT TGGAGATGAGTGGGAACGAATGTCTGAATCAGGCTTTAAACTGTTGTGCCAGTGCTTAGGCTTTGGAAGTGGTCATTTCAGATGTGATTCATCTAGATGG TGCCATGACAATGGTGTGAACTACAAGATTGGAGAGAAGTGGGACCGTCAGGGAGAAAATGGCCAGATGATGAGCTGCACATGTCTTGGGAACGGAAAAG GAGAATTCAAGTGTGACCCTCATGAGGCAACGTGTTATGATGATGGGAAGACATACCACGTAGGAGAACAGTGGCAGAAGGAATATCTCGGTGCCATTTG CTCCTGCACATGCTTTGGAGGCCAGCGGGGCTGGCGCTGTGACAACTGCCGCAGACCTGGGGGTGAACCCAGTCCCGAAGGCACTACTGGCCAGTCCTAC AACCAGTATTCTCAGAGATACCATCAGAGAACAAACACTAATGTTAATTGCCCAATTGAGTGCTTCATGCCTTTAGATGTACAGGCTGACAGAGAAGATT CCCGAGAGTAAATCATCTTTCCAATCCAGAGGAACAAGCATGTCTCTCTGCCAAGATCCATCTAAACTGGAGTGATGTTAGCAGACCCAGCTTAGAGTTC TTCTTTCTTTCTTAAGCCCTTTGCTCTGGAGGAAGTTCTCCAGCTTCAGCTCAACTCACAGCTTCTCCAAGCATCACCCTGGGAGTTTCCTGAGGGTTTT CTCATAAATGAGGGCTGCACATTGCCTGTTCTGCTTCGAAGTATTCAATACCGCTCAGTATTTTAAATGAAGTGATTCTAAGATTTGGTTTGGGATCAAT AGGAAAGCATATGCAGCCAACCAAGATGCAAATGTTTTGAAATGATATGACCAAAATTTTAAGTAGGAAAGTCACCCAAACACTTCTGCTTTCACTTAAG TGTCTGGCCCGCAATACTGTAGGAACAAGCATGATCTTGTTACTGTGATATTTTAAATATCCACAGTACTCACTTTTTCCAAATGATCCTAGTAATTGCC TAGAAATATCTTTCTCTTACCTGTTATTTATCAATTTTTCCCAGTATTTTTATACGGAAAAAATTGTATTGAAAACACTTAGTATGCAGTTGATAAGAGG AATTTGGTATAATTATGGTGGGTGATTATTTTTTATACTGTATGTGCCAAAGCTTTACTACTGTGGAAAGACAACTGTTTTAATAAAAGATTTACATTCC ACAACTTGAAGTTCATCTATTTGATATAAGACACCTTCGGGGGAAATAATTCCTGTGAATATTCTTTTTCAATTCAGCAAACATTTGAAAATCTATGATG TGCAAGTCTAATTGTTGATTTCAGTACAAGATTTTCTAAATCAGTTGCTACAAAAACTGATTGGTTTTTGTCACTTCATCTCTTCACTAATGGAGATAGC TTTACACTTTCTGCTTTAATAGATTTAAGTGGACCCCAATATTTATTAAAATTGCTAGTTTACCGTTCAGAAGTATAATAGAAATAATCTTTAGTTGCTC TTTTCTAACCATTGTAATTCTTCCCTTCTTCCCTCCACCTTTCCTTCATTGAATAAACCTCTGTTCAAAGAGATTGCCTGCAAGGGAAATAAAAATGACT AAGATATTAAAAGTATTTGAATAGTATAATATGGAGGAGTTTTATCTTAGGGAAACCCCATGGTATGATAACCCCCATCTAACATGTCTTACTTTGGGTC AGCTGACACTTTTGGCATGGCTTGATAAACTCCCAGCTAAACAGTTTGTTTACTCCTGATCTGTAAAGGTCATTTCTTTTTCAATTTAACATTGAGGAAA CAAACTTTGGGATTAAATTTGACATTCAGGCCAGGCGCAGTGGCTCACACCTCTAATCCCAGCACTTTGGGAGGCTGAGGCAGGTGGATCACCTGAGGTC AGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCTTGTCTCTATTAAAAATACAAATGTTACCAGGCATGGCAGTGGGCGTCTTTGGTCCCGGCTAC TCAGAAGGCTGAGGTAGGAGAATGGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCTGAGATTGTGCCATTGAACTCCAGCATGGGGGACAGAGCAAGA CTCCATCCCAAAAAACATAAATAAATAAATGTGACATTCAGAATAGTAAATAGTGGAAATGGAAATAATTATTAGTAAAAAATTAGTAGTTCATAATAAA CAAGACATGCAAAGCACTTTTTAAATATACTAATGTACAATGAAAGAAGGTATTTCAATAAACACCTGGCAAAGAATATTAAAACTAAATACAGAAAGAT ACTTCCTCATGTTCATTTGAAAAAAAAAAATACTAACTCCCATTTGAATTGATTTACAGTTTATAAAATGCTTTGACATTTAGCTATCTCATTTAGGGGA GGTTTTAGAGCTTAATTTTACAGGGCATGAAGCTCAGATGAGGTTTCCTTAGCGAAATACAGACCCAGCCCCTGGACTTCTATTTATTACTGATCTTTAA GCTTTATCAGCCCAATAGTCACCAAGAGAGCTGCTCTGTATGTTTTTTAAAAATCACAGAAAGTACAAAATAAAGGTGATATTAAACGACTGTC

FN1.u.f.55 (forward primer)
FN1.u.r.66 (reverse primer)
Single exon skipping

Frame 0

RGGDSPAGLSSPAPRASRGAGGDRPI*APAPGA RTPAPAVLHRGRRGNPRREREEGTCSHNFSGPLH PFCPSTRPLPHPLAPTFLEATTPGRH*KGFFPQ VAKGSKLGGNLPPGAGVSPPPSQHA*GSGARAA AAGRPVPGDSGALHGSLEEQEAGSANGSAPVPGG CQSKQARLL*QWKTLSDKSTVGADLPRQCVGLY LLWRKPRF*LRE*T*S*RDLL*QVHWEHLPSG* HL*AS*RLHDLGLYLHRGWARENKLYHRKPLP*R GSVLQDW*HLEETT*DWWLHVRVCVSW*WKRRM DLQAHS*EVF*SCCWDFLCGRRNVGEALPRLDD GRLYLPGRRQRTHHLHF*K*MQRSGHKDIL*NWR HLEQEG*SRKPAPVHLHRQRPRRVEV*EAHLCA DHIERIWPLHRCSCSCLPTAASPPASSLWPLCH RQWCGLLCGDAVAEDTRK*ANALHVPGQRSQLPR DSCNPDLRWQLKWRAMCLTIHLQWQDVLLLHHR RATGRTSLVQHNFEL*AGPEILFLHRPHCFGSD SRRKFQWCLVPLPLPIQQPQLH*LHF*GQKRQHE VVWDHTEL*CRPEVWVLPHGCPRGNLHNQ*RGH VPHWRSVG*AA*HGSHDEVHVCWEWSWGMDMHC LLAASRSVHC**HHLQCERHIPQAS*RGAHAELY MLRSGSGQVEV*SRRPMPGFRDWDVLSNWRFMG EVCAWCQIPVLLLWPWHWGVALPTFTDLSKLKW SCRSIYH*DSESAQLPPHPVECTTAISHFQVHSQ VET*KFCRPLEGSYHTRPLKLLHHQRPEAWCGI RGPAHQHPAVRPPRSDSL*LHHHQHQHTCDQQH RDRRDDSLFSSCGHF*ICDRNHSQ*LCGLLGLSF RHRVGIPGGI*AE*GGR*ATVPGSSKHSHFCEH P*PASWPKIHCKCLSDI*GWGAEFDPVYFTNNS A*CPS*HDCGPS**HLNCCSLEQTPGSHHRVQNS LFAISRR*QHRTQPS*NCKLRHPQ*LATWCSV* HHYLCCGRKSRKYTCCHSTRNHWHPTLRYSALS QGPAVCGSDRREGHHHVDTA*ECSDRLPCGCDPR QPAWRARAEAAHQQEHLCRSHRAVPWGHLLLQS LCSEPWEGEQASDCSTDNQTGCSH*PPVCQ*N* FYCPGEMDSTSGPDNRIPTDRGPYPKRTAQAVQC GSLCLQVPTEESAACI*VHRIPRGHKGQPREPQ SHWSLYHTAAWELYSTLQHRGD*DHHCDHMDAC SKNWF*AGCTTKPGRRGTTRSDFRLRKHRCVRLD SRSRIRLHHPSPERWTGKRCANCKQSGDTIVST NKLASGGKP*HWSAHSLLGEEHHPRHYWL*NYH NPYKRPAGKFFGRSGPC*SELLHF**PESRPGVQ CQCLHCQG*QGKCPYL*YHHPRGAPTH*PKLC* YNRFKHRPEVDPAKLFHHYWVPHHSSCGRRRYP YF*RFCGLLSRILHSHRAGAGH*L*YQRYHSH*W RRECPYYTDTTNGCSSSH*PAIHQHWSRHHACH LGSTPIH*FNQLPGALLTCEK*GRCCRVVNFSF RQCSGLNKSPAWYRICSECLQCLRTT*EHTS*RK TENRS*FPNWH*LF*YYCQLFYCALDCSSSHHH WLQDPPSSRALQWETSRRSGAPLSEFHHPHQPH SRHRVCGQHRCS*WQRGKSLIDWPTINSF*CSEG PGSCCCDPHQPTDQLGCSCCHSEILQDHLRRDR RK*PCPGVHCAWEQVYSYHQRP*TWS*LYHHCV CCHWPWRQPRKQQANFH*LPNRN*QTIPDASDRC SGQQH*CQVAAFKFPCYWLQSNHHSQKWTRTNK N*NCRSRSNRNDY*RLAAHSGVCG*CLCSESKR RESASGSDCSNQH*SP*RTGIH*CGCRFHQNCLG KPTGASFQVQGDLLEP*GWNP*AIPCT*W*RRH CRAARPQTGF*VHSQCGCLAR*YGEPAPDWNPV HSYSCTN*PEVHSGHTHKPERPVDTTQCSAHWIS SAGDPQGEDRTNERNQPCS*QLIRGCIRTYGGH QI*SECLCS*GHFDKQTSSGSCHHSGECQPTKK GSCDRCY*DHHHH*LENQD*DDHWLPS*CRSSQW PDSNPENHQARCQKLHHHRFTTRH*LQDLPVHL E*QCSELPCGHRRLHCH*CTIQPAFPGHHTQFL AGIMAAATCQDYRLHHQV*EAWVSSQRSGPSAPP WCHRGYYYWPGTGNRIYNLCHCPEE*SEERAPD WKEKDRRASPTGNPSTPQSSWTRDLGCSFHSSK DPFRHPPWV*HWKWYSASWHFWSATQCWATNDL* GTWF*ADHTAHNGHPHKA*AKTIPAECRTRSSL SDNHLMGPIPGHF*VHHFMSSCWH**RTLTVQG SWNFYQCHSDRPHQRCHLQRHSGGTERPAEA*GS GRGCYRGQLCQRRLEPTYG*LVL*PLHSFPLCR WR*VGTNV*IRL*TVVPVLRLWKWSFQM*FI*M VP*QWCELQDWREVGPSGRKWPDDELHMSWERKR RIQV*PS*GNVL**WEDIPRRRTVAEGISRCHL LLHMLWRPAGLAL*QLPQTWG*TQSRRHYWPVL QPVFSEIPSENKH*C*LPN*VLHAFRCTG*QRRF PRVNHLSNPEEQACLSAKIHLNWSDVSRPSLEF FFLS*ALCSGGSSPASAQLTASPSITLGVS*GF SHK*GLHIACSASKYSIPLSILNEVILRFGLGSI GKHMQPTKMQMF*NDMTKILSRKVTQTLLLSLK CLARNTVGTSMILLL*YFKYPQYSLFPNDPSNC LEISFSYLLFINFSQYFYTEKIVLKTLSMQLIRG IWYNYGG*LFFILYVPKLYYCGKTTVLIKDLHS TT*SSSI*YKTPSGEIIPVNILFQFSKHLKIYD VQV*LLISVQDFLNQLLQKLIGFCHFISSLMEIA LHFLL**I*VDPNIY*NC*FTVQKYNRNNL*LL FSNHCNSSLLPSTFPSLNKPLFKEIACKGNKND *DIKSI*IV*YGGVLS*GNPMV**PPSNMSYFGS ADTFGMA**TPS*TVCLLLICKGHFFFNLTLRK QTLGLNLTFRPGAVAHTSNPSTLGG*GRWIT*G QEFETSLANMVKPCLY*KYKCYQAWQWASLVPAT QKAEVGEWLEPRRRRLQ*AEIVPLNSSMGDRAR LHPKKHK*INVTFRIVNSGNGNNY**KISSS** TRHAKHFLNILMYNERRYFNKHLAKNIKTKYRKI LPHVHLKKKNTNSHLN*FTVYKML*HLAISFRG GFRA*FYRA*SSDEVSLAKYRPSPWTSIYY*SL SFISPIVTKRAALYVF*KSQKVQNKGDIKRL

Frame 1

GAGTARRVSPPPRPGPPEGREGTVPYKPRLPAL GRPRRLCCTGGGEGTPGASGKRGPAATTSLVLC IPSVPPPVPFPTLWPPPSWRRQPPGGIRRDFSRR LRREANLVATCLPVRASLPHRLNMLRGPGPGLL LLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPV AVSQSKPGCYDNGKHYQINQQWERTYLGNALVCT CYGGSRGFNCESKPEAEETCFDKYTGNTYRVGD TYERPKDSMIWDCTCIGAGRGRISCTIANRCHE GGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEW TCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMM VDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIG DTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQ TTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVT DSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQ ETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTE GRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQT RGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNM KWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVM YRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIA YSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNC TCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWE KYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSG PVEVFITETPSQPNSHPIQWNAPQPSHISKYIL RWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVY EGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNT VTGETTPFSPLVATSESVTEITASSFVVSWVSA SDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNI PDLLPGRKYIVNVYQISEDGEQSLILSTSQTTA PDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRI VYSPSVEGSSTELNLPETANSVTLSDLQPGVQYN ITIYAVEENQESTPVVIQQETTGTPRSDTVPSP RDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIP VNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKV FAVSHGRESKPLTAQQTTKLDAPTNLQFVNETD STVLVRWTPPRAQITGYRLTVGLTRRGQPRQYN VGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPK ATGVFTTLQPGSSIPPYNTEVTETTIVITWTPA PRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGL TPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPP TNLHLEANPDTGVLTVSWERSTTPDITGYRITT TPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEY NVSVYTVKDDKESVPISDTIIPEVPQLTDLSFVD ITDSSIGLRWTPLNSSTIIGYRITVVAAGEGIP IFEDFVDSSVGYYTVTGLEPGIDYDISVITLIN GGESAPTTLTQQTAVPPPTDLRFTNIGPDTMRVT WAPPPSIDLTNFLVRYSPVKNEEDVAELSISPS DNAVVLTNLLPGTEYVVSVSSVYEQHESTPLRG RQKTGLDSPTGIDFSDITANSFTVHWIAPRATIT GYRIRHHPEHFSGRPREDRVPHSRNSITLTNLT PGTEYVVSIVALNGREESPLLIGQQSTVSDVPR DLEVVAATPTSLLISWDAPAVTVRYYRITYGETG GNSPVQEFTVPGSKSTATISGLKPGVDYTITVY AVTGRGDSPASSKPISINYRTEIDKPSQMQVTD VQDNSISVKWLPSSSPVTGYRVTTTPKNGPGPTK TKTAGPDQTEMTIEGLQPTVEYVVSVYAQNPSG ESQPLVQTAVTNIDRPKGLAFTDVDVDSIKIAW ESPQGQVSRYRVTYSSPEDGIHELFPAPDGEEDT AELQGLRPGSEYTVSVVALHDDMESQPLIGTQS TAIPAPTDLKFTQVTPTSLSAQWTPPNVQLTGY RVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVAT KYEVSVYALKDTLTSRPAQGVVTTLENVSPPRR ARVTDATETTITISWRTKTETITGFQVDAVPAN GQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYTL NDNARSSPVVIDASTAIDAPSNLRFLATTPNSL LVSWQPPRARITGYIIKYEKPGSPPREVVPRPR PGVTEATITGLEPGTEYTIYVIALKNNQKSEPLI GRKKTDELPQLVTLPHPNLHGPEILDVPSTVQK TPFVTHPGYDTGNGIQLPGTSGQQPSVGQQMIF EEHGFRRTTPPTTATPIRHRPRPYPPNVGQEALS QTTISWAPFQDTSEYIISCHPVGTDEEPLQFRV PGTSTSATLTGLTRGATYNVIVEALKDQQRHKV REEVVTVGNSVNEGLNQPTDDSCFDPYTVSHYAV GDEWERMSESGFKLLCQCLGFGSGHFRCDSSRW CHDNGVNYKIGEKWDRQGENGQMMSCTCLGNGK GEFKCDPHEATCYDDGKTYHVGEQWQKEYLGAIC SCTCFGGQRGWRCDNCRRPGGEPSPEGTTGQSY NQYSQRYHQRTNTNVNCPIECFMPLDVQADRED SRE*IIFPIQRNKHVSLPRSI*TGVMLADPA*SS SFFLKPFALEEVLQLQLNSQLLQASPWEFPEGF LINEGCTLPVLLRSIQYRSVF*MK*F*DLVWDQ *ESICSQPRCKCFEMI*PKF*VGKSPKHFCFHLS VWPAIL*EQA*SCYCDILNIHSTHFFQMILVIA *KYLSLTCYLSIFPSIFIRKKLY*KHLVCS**E EFGIIMVGDYFLYCMCQSFTTVERQLF**KIYIP QLEVHLFDIRHLRGK*FL*IFFFNSANI*KSMM CKSNC*FQYKIF*ISCYKN*LVFVTSSLH*WR* LYTFCFNRFKWTPIFIKIASLPFRSIIEIIFSCS FLTIVILPFFPPPFLH*INLCSKRLPAREIKMT KILKVFE*YNMEEFYLRETPWYDNPHLTCLTLG QLTLLAWLDKLPAKQFVYS*SVKVISFSI*H*GN KLWD*I*HSGQAQWLTPLIPALWEAEAGGSPEV RSLRPAWPTW*NLVSIKNTNVTRHGSGRLWSRL LRRLR*ENGLNPEGGGCSELRLCH*TPAWGTEQD SIPKNINK*M*HSE**IVEMEIIISKKLVVHNK QDMQSTF*IY*CTMKEGISINTWQRILKLNTER YFLMFI*KKKILTPI*IDLQFIKCFDI*LSHLGE VLELNFTGHEAQMRFP*RNTDPAPGLLFITDL* ALSAQ*SPRELLCMFFKNHRKYKIKVILNDC

Frame 2

GRGQPGGSLLPRAPGLQRGGRGPSHISPGSRRS DARAGCAAQGEEREPQARAGRGDLQPQLLWSSA SLLSLHPSPSPPSGPHLLGGDNPREALEGIFPA GCEGKQTWWQLASRCGRLSPTVSTCLGVRGPGCC CWPSSAWGQRCPPREPRRARGRLSKWFSPSPRW LSVKASPVVMTMENTIR*INSGSGPT*AMRWFV LVMEEAEVLTARVNLKLKRLALTSTLGTLTEWVT LMSVLKTP*SGTVPASGLGEGE*AVPSQTAAMK GVSPTRLVTPGGDHMRLVVTC*SVCVLVMEKEN GPASP*LRSVLIMLLGLPMWSEKRGRSPTKAG*W *IVLAWEKAADASLALLEIDATIRTQGHPIELE TPGARRIIEETCSSASAQATAEESGSVRGTPLC RPHRADLAPSPMFVQLFTNRSLTPSLLPMATVSQ TVVWSTLWGCSG*RHKEISKCFARAWATESAAK RQL*PRLTVATQMESHVSYHSPTMAGRSTPAPQ KGDRTDIFGAAQLRIMSRTRNTLSAQTTLFWFRL EEEIPMVPCATSPSYTTTTITLIALLRAEETT* SGVGPHRTMMPTRSLGSAPWLPTRKSAQPMKGS CTALEISGISSMTWVT**GARVLGMVVGNGHALP TRSFEISALLMTSLTM*TTHSTSVMKRGTC*TV HASVRVGAGGSVIPSTNARIQRLGRFIKLEIHG RSMCMVSDTSATAMAVALGSGIANLYRPIQAQVV LSKYLSLRLRVSPTPTPSSGMHHSHLTFPSTFS GGDLKIL*AVGRKLPYQAT*TPTPSKA*SLVWY TRASSSASSSTATKK*LALTSPPPAPAHL*PATP *QERRLPFLLLWPLLNL*PKSQPVALWSPGSQL PTPCRDSGWNMS*VRREMSHSTWIFQAQPLL*T SLTCFLAENTL*MSIRYLRMGSRV*SCLLHKQQR LMPLLTRLWTKLMTPQLLFAGADPRLPSQGTE* SIRHQ*KVAAQNSTFLKLQTPSPSVTCNLVFSI TSLSMLWKKIKKVHLLSFNKKPLAPHAQIQCPLP GTCSLWK*QT*RSPSCGHRLRVQ*PATVWM*SP STCLASTGRGCPSAGTPLQKSPGCPLGSPITSK SLQ*AMGGRASL*LLNRQPNWMLPLTSSLSMKLI LLSW*DGLHLGPR*QDTD*PWALPEEDSPGSTM WVPLSPSTH*GICSLHLSTPYPSWP*RATKRAP KPLESLPHCSLGALFHLTTPR*LRPPL*SHGRLL QELVLSWVYDQAREERHHEK*LQTQEASLCPA* LQE*NTSTPSKS*EMDRKEMRQL*TKW*HHCLH QQTCIWRQTLTLECSQSPGRGAPPQTLLVIELPQ PLQTASREILWKKWSMLIRAPALLIT*VPAWST MSVFTLSRMTRKVSLSLIPSSQRCPNSLT*ALL I*PIQASA*GGPR*TLPPLLGTASQ*LRQEKVSL FLKILWTPQ*DTTQSQGWSRALTMISALSLSLM AARVPLLH*HNKRLFLLPLTCDSPTLVQTPCVS PGLHPHPLI*PTSWCVTHL*KMRKMLQSCQFLLQ TMQWS*QISCLVQNM**VSPVSTNNMRAHLLEE DRKQVLIPQLALTFLILLPTLLLCTGLLLEPPS LATGSAIIPSTSVGDLEKIGCPTLGIPSPSPTSL QAQSMWSASLLLMAERKVPY*LANNQQFLMFRG TWKLLLRPPPAY*SAGMLLLSQ*DITGSLTERQ EEIALSRSSLCLGASLQLPSAALNLELIIPSLCM LSLAVETAPQAASQFPLITEQKLTNHPRCK*PM FRTTALVSSGCLQVPLLLVTE*PPLPKMDQDQQ KLKLQVQIKQK*LLKACSPQWSMWLVSMLRIQAE RVSLWFRLQ*PTLIALKDWHSLMWMSIPSKLLG KAHRGKFPGTG*PTRALRMESMSYSLHLMVKKT LQSCKASDRVLSTQSVWLPCTMIWRASP*LEPSP QLFLHQLT*SSLRSHPQA*APSGHHPMFSSLDI ECG*PPRRRPDQ*KKSTLLLTAHPWLYQDLWWP PNMK*VSMLLRTL*QADQLRELSPLWRMSAHQEG LV*QMLLRPPSPLAGEPRLRRSLASKLMPFQPM ARLQSREPSSQMSEATPSQVYNQALTTRSTCTP *MTMLGAPLWSSTPPLPLMHHPTCVSWPPHPIPC WYHGSRHVPGLPATSSSMRSLGLLPEKWSLGPA LVSQRLLLLAWNREPNIQFMSLP*RIIRRASP* LEGKRQTSFPNW*PFHTPIFMDQRSWMFLPQFKR PLSSPTLGMTLEMVFSFLALLVSNPVLGNK*SL RNMVLGGPHRPQRPPP*GIGQDHTRRM*DKKLS LRQPSHGPHSRTLLSTSFHVILLALMKNPYSSGF LELLPVPL*QASPEVPPTTS*WRH*KTSRGIRF GKRLLPWATLSTKA*TNLRMTRALTPTQFPIMP LEMSGNECLNQALNCCASA*ALEVVISDVIHLDG AMTMV*TTRLERSGTVREKMAR**AAHVLGTEK ENSSVTLMRQRVMMMGRHTT*ENSGRRNISVPF APAHALEASGAGAVTTAADLGVNPVPKALLASPT TSILRDTIREQTLMLIAQLSASCL*MYRLTEKI PESKSSFQSRGTSMSLCQDPSKLE*C*QTQLRV LLSFLSPLLWRKFSSFSSTHSFSKHHPGSFLRVF S*MRAAHCLFCFEVFNTAQYFK*SDSKIWFGIN RKAYAANQDANVLK*YDQNFK*ESHPNTSAFT* VSGPQYCRNKHDLVTVIF*ISTVLTFSK*S**LP RNIFLLPVIYQFFPVFLYGKNCIENT*YAVDKR NLV*LWWVIIFYTVCAKALLLWKDNCFNKRFTF HNLKFIYLI*DTFGGNNSCEYSFSIQQTFENL*C ASLIVDFSTRFSKSVATKTDWFLSLHLFTNGDS FTLSALIDLSGPQYLLKLLVYRSEV**K*SLVA LF*PL*FFPSSLHLSFIE*TSVQRDCLQGK*K*L RY*KYLNSIIWRSFILGKPHGMITPI*HVLLWV S*HFWHGLINSQLNSLFTPDL*RSFLFQFNIEE TNFGIKFDIQARRSGSHL*SQHFGRLRQVDHLRS GV*DQPGQHGETLSLLKIQMLPGMAVGVFGPGY SEG*GRRMA*TQKAEVAVS*DCAIELQHGGQSK TPSQKT*INKCDIQNSK*WKWK*LLVKN**FIIN KTCKALFKYTNVQ*KKVFQ*TPGKEY*N*IQKD TSSCSFEKKKY*LPFELIYSL*NALTFSYLI*G RF*SLILQGMKLR*GFLSEIQTQPLDFYLLLIFK LYQPNSHQESCSVCFLKITESTK*R*Y*TTV