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Sequences

Sequence WISP1.dAug05

ATATCTGGTGCTCCTGATGGGCCGGCCAGTCTGGGCCCAGCTCCCCCGAGAGGTGGTCGGATCCTCTGGGCTGCTCGGTCGATGCCTGTGCCACTGACGT CCAGGCATGAGGTGGTTCCTGCCCTGGACGCTGGCAGCAGTGACAGCAGCAGCCGCCAGCACCGTCCTGGCCACGGCCCTCTCTCCAGCCCCTACGACCA TGGACTTTACCCCAGCTCCACTGGAGGACACCTCCTCACGCCCCCAATTCTGCAAGTGGCCATGTGAGTGCCCGCCATCCCCACCCCGCTGCCCGCTGGG GGTCAGCCTCATCACAGATGGCTGTGAGTGCTGTAAGATGTGCGCTCAGCAGCTTGGGGACAACTGCACGGAGGCTGCCATCTGTGACCCCCACCGGGGC CTCTACTGTGACTACAGCGGGGACCGCCCGAGGTACGCAATAGGAGTGTGTGCACGCAGGGAAGAAGTGTCTGGCTGTGTACCAGCCAGAGGCATCCATG AACTTCACACTTGCGGGCTGCATCAGCACACGCTCCTATCAACCCAAGTACTGTGGAGTTTGCATGGACAATAGGTGCTGCATCCCCTACAAGTCTAAGA CTATCGACGTGTCCTTCCAGTGTCCTGATGGGCTTGGCTTCTCCCGCCAGGTCCTATGGATTAATGCCTGCTTCTGTAACCTGAGCTGTAGGAATCCCAA TGACATCTTTGCTGACTTGGAATCCTACCCTGACTTCTCAGAAATTGCCAACTAGGCAGGCACAAATCTTGGGTCTTGGGGACTAACCCAATGCCTGTGA AGCAGTCAGCCCTTATGGCCAATAACTTTTCACCAATGAGCCTTAGTTACCCTGATCTGGACCCTTGGCCTCCATTTCTGTCTCTAACCATTCAAATGAC GCCTGATGGTGCTGCTCAGGCCCATGCTATGAGTTTTCTCCTTGATATCATTCAGCATCTACTCTAAAGAAAAATGCCTGTCTCTAGCTGTTCTGGACTA CACCCAAGCCTGATCCAGCCTTTCCAAGTCACTAGAAGTCCTGCTGGATCTTGCCTAAATCCCAAGAAATGGAATCAGGTAGACTTTTAATATCACTAAT TTCTTCTTTAGATGCCAAACCACAAGACTCTTTGGGTCCATTCAGATGAATAGATGGAATTTGGAACAATAGAATAATCTATTATTTGGAGCCTGCCAAG AGGTACTGTAATGGGTAATTCTGACGTCAGCGCACCAAAACTATCCTGATTCCAAATATGTATGCACCTCAAGGTCATCAAACATTTGCCAAGTGAGTTG AATAGTTGCTTAATTTTGATTTTTAATGGAAAGTTGTATCCATTAACCTGGGCATTGTTGAGGTTAAGTTTCTCTTCACCCCTACACTGTGAAGGGTACA GATTAGGTTTGTCCCAGTCAGAAATAAAATTTGATAAACATTCCTGTTGATGGGAAAAGCCCCCAGTTAATACTCCAGAGACAGGGAAAGGTCAGCCCGT TTCAGAAGGACCAATTGACTCTCACACTGAATCAGCTGCTGACTGGCAGGGCTTTGGGCAGTTGGCCAGGCTCTTCCTTGAATCTTCTCCCTTGTCCTGC TTGGGGTTCATAGGAATTGGTAAGGCCTCTGGACTGGCCTGTCTGGCCCCTGAGAGTGGTGCCCTGGAACACTCCTCTACTCTTACAGAGCCTTGAGAGA CCCAGCTGCAGACCATGCCAGACCCACTGAAATGACCAAGACAGGTTCAGGTAGGGGTGTGGGTCAAACCAAGAAGTGGGTGCCCTTGGTAGCAGCCTGG GGTGACCTCTAGAGCTGGAGGCTGTGGGACTCCAGGGGCCCCCGTGTTCAGGACACATCTATTGCAGAGACTCATTTCACAGCCTTTCGTTCTGCTGACC AAATGGCCAGTTTTCTGGTAGGAAGATGGAGGTTTACCGGTTGTTTAGAAACAGAAATAGACTTAATAAAGGTTTAAAGCTGAAGAGGTTGAAGCTAAAA GGAAAAGGTTGTTGTTAATGAATATCAGGCTATTATTTATTGTATTAGGAAAATATAATATTTACTGTTAGAATTCTTTTATTTAGGGCCTTTTCTGTGC CAGACATTGCTCTCAGTGCTTTGCATGTATTAGCTCACTGAATCTTCACGACAATGTTGAGAAGTTCCCATTATTATTTCTGTTCTTACAAATGTGAAAC GGAAGCTCATAGAGGTGAGAAAACTCAACCAGAGTCACCCAGTTGGTGACTGGGAAAGTTAGGATTCAGATCGAAATTGGACTGTCTTTATAACCCATAT TTTCCCCCTGTTTTTAGAGCTTCCAAATGTGTCAGAATAGGAAAACATTGCAATAAATGGCTTGATTTTTTAATGTCATTTTTCCCTCTTATAGTCTTTC TAGCTCCTTTTCAAAAGACGAGAATATCTGATTTTCTGATAATTTAGGTGCTTAAGCATCCAAAATACATGGGACACACAAAAATCCAGGAATCCCCTGT AGCTTATTCCCTCTTTCCCATCGGAACCAGCTCTCATCACACATTTAAAAGATGATTCTGTTTACCCAATGCTGCATATTGAATGTTGTGTAGTTATTCA CAGGGAATTCTGTGCAGTGTGCAGAGAGATTCCTAAACGGGAAAAGGACTGGGAATACATCCTCCTTACTGTGACCTCCCCAAAACCTAGTCCAGTGCAA GGTATACAGTGGTGCTCATTAAATACTTGATGAATACAGGAAGCTGTGCATGTGTTCCTACTTTTATTCGAAGCTCTCTTCTTCCAAAGCTACATGAAAA TAGAATTTTAACAGTCAAAATTTTATATTAAGTGCCTTAGCAAAAGAGACATTTAATATTTCAAAGAAATGCATATGTATGTATACATATATTTGTGTAT GCGTATGCAAGAATTCTTGTATAAAGAGAATTCACTCCATGAATGATCTCTTCTGTAAGTCAGTGTGAATCATGTTAGATTTTCTGAGAGTGAAAACACC TGCCATCTACAAATTACAAGGCTGGATAACAGCTCACTCCATTTGAAATTCAGTGGAAACCCAAGAGCTAGGTTCTTACTGAATTTGCATCTCAATTTGG GAAACTGAACTTAGCTTTCAAAGATCATAGGAAGTCTGGTTGGAGAAACTAGGGATTATTCTGGCAATGGGTGCAGGAAGGTGGTCAGAATAACCCAGTC GCCATTGGTTTTGAGAAACGGAACTATCTTATGCAGAGCCCGGAGGGCAAGTCTCAGACCCATGGGTTGAAGCCATGGAGAAGGAAATTTGGATCCAATG TAATGAAGCGCTTTCTAAGTCAGAATTTCCCTGCAATGGTGTGGCCTGATTCAATAAAAATTAAGAATAATAAATATAATGGAAAAAAATCTCCACTGAT TGAGTGTTTACTTGGTGCCAAGCACTATGCTAAGTTGTTCATTATTTTATTTAATTGTTACAGCAATTTTGAGTATGCATCTTTCACTATTTTATAAGTG GAAAAGAGAAGTGCCCCCAAAAAGTTAGAGCTCAAACAGCAGCTTATTCTACCAGCCCCTGCTCTTGCGGAGGCCTCTGGAAAAGACCTGAATGACACCT ATTGGAGAATTACATCTACAAGGGGCTTCAAACAGACCAAATAGATCATCACCTCTGTGGTCCCTTGTTAACTATATGTTCTGAGACAAAGGAAAGCTAC CCTAAGGGTTAGTTAACCTTTGCTGAGGAAATTTACATTCATACTTAGAGTGAATTACTCAGGTGTGCTTAGGTGTGCAAAAGGGAAGGAGACCTGAATT CACCAAGTTAAATCTTGCTAAACCTTATCATAAGCATTTTTTGAGCGCTTAGCATACACCAAGCCTTGTGGAAGGTGCTTTCCTGCCATATCTCATTTAA TCCTCACAGCAAACCTATAGAATATGGCATTATCATCTGAGTCTCACAGAAGTTTAGTCGTGTACTCAAGGTCTTACCAGCTAGTGAACAGCAGACCAAG ACTGGAAACCCAGGATAGTCTGATACCTGAGCCATCTCTTCTTGTGCTACGCCTAGTTATTCTGTCCCCCAAATCAAAAGGCATGACCTTTATAAGAGGC GCTTTACTGACAATAGCTGCAATTTTAACTTTGAAAATGATTCAGAATTATCAAAGATAGTAGATTCGAATGACATGATTGTCTATAATCTCGCTAGCCT TGTACTGTGTGTGCATAGCAATTACAGGGAAGTAATCTAGCTCCTGACTATTATGTTGAACTATGTCGCTGCTTTTTACAAACTTGTCTTGATCCAAAGC AGTCACAATGATAACCCTGCATATCTGGGAATCATAAGTCAACTATGTATCCCTGTGTGTGTATATATATGTATGTATGTATCTATTTTCAAACTGTGAT TTAATATTTAAATATTCCTACTGCCATTTTTGTGACTGAAAAACTACACATGAGGAAACGTCTTAGAATTTTCCAATAGAGGAAAAATAACACTTGGGCA ATCTGTCATGTTTCACAACAGTTCTCATTTTTCTCATGATTTGTGTAGCGTGGAATGTGTTTGCTCAATGTGAAGGGTTTTCATTGCTCAATTTCTCTGT GTAAGTCTTTTCCTTAAGGTAATAAACCATCAGCAAAGTCACATACTGGAGTTGGTGGCTTTTCTTGTACAGGCAGTTGTTATGAGACAATGATGGAGCA TTGAGCATGTTCAATAAATGTGCAGATGGTGGAAA

WISP1.u.f.4 (forward primer)
WISP1.u.r.4 (reverse primer)
Multiple exon skipping

Frame 0

ISGAPDGPASLGPAPPRGGRILWAARSMPVPLT SRHEVVPALDAGSSDSSSRQHRPGHGPLSSPYDH GLYPSSTGGHLLTPPILQVAM*VPAIPTPLPAG GQPHHRWL*VL*DVRSAAWGQLHGGCHL*PPPG PLL*LQRGPPEVRNRSVCTQGRSVWLCTSQRHP* TSHLRAASAHAPINPSTVEFAWTIGAASPTSLR LSTCPSSVLMGLASPARSYGLMPASVT*AVGIP MTSLLTWNPTLTSQKLPTRQAQILGLGD*PNACE AVSPYGQ*LFTNEP*LP*SGPLASISVSNHSND A*WCCSGPCYEFSP*YHSASTLKKNACL*LFWT TPKPDPAFPSH*KSCWILPKSQEMESGRLLISLI SSLDAKPQDSLGPFR*IDGIWNNRIIYYLEPAK RYCNG*F*RQRTKTILIPNMYAPQGHQTFAK*V E*LLNFDF*WKVVSINLGIVEVKFLFTPTL*RVQ IRFVPVRNKI**TFLLMGKAPS*YSRDRERSAR FRRTN*LSH*ISC*LAGLWAVGQALP*IFSLVL LGVHRNW*GLWTGLSGP*EWCPGTLLYSYRALRD PAADHARPTEMTKTGSGRGVGQTKKWVPLVAAW GDL*SWRLWDSRGPRVQDTSIAETHFTAFRSAD QMASFLVGRWRFTGCLETEIDLIKV*S*RG*S*K EKVVVNEYQAIIYCIRKI*YLLLEFFYLGPFLC QTLLSVLCMY*LTESSRQC*EVPIIISVLTNVK RKLIEVRKLNQSHPVGDWES*DSDRNWTVFITHI FPLFLELPNVSE*ENIAINGLIF*CHFSLL*SF *LLFKRREYLIF**FRCLSIQNTWDTQKSRNPL *LIPSFPSEPALITHLKDDSVYPMLHIECCVVIH REFCAVCREIPKREKDWEYILLTVTSPKPSPVQ GIQWCSLNT**IQEAVHVFLLLFEALFFQSYMK IEF*QSKFYIKCLSKRDI*YFKEMHMYVYIYLCM RMQEFLYKENSLHE*SLL*VSVNHVRFSESENT CHLQITRLDNSSLHLKFSGNPRARFLLNLHLNL GN*T*LSKIIGSLVGETRDYSGNGCRKVVRITQS PLVLRNGTILCRARRASLRPMG*SHGEGNLDPM **SAF*VRISLQWCGLIQ*KLRIINIMEKNLH* LSVYLVPSTMLSCSLFYLIVTAILSMHLSLFYKW KREVPPKS*SSNSSLFYQPLLLRRPLEKT*MTP IGELHLQGASNRPNRSSPLWSLVNYMF*DKGKL P*GLVNLC*GNLHSYLE*ITQVCLGVQKGRRPEF TKLNLAKPYHKHFLSA*HTPSLVEGAFLPYLI* SSQQTYRIWHYHLSLTEV*SCTQGLTS**TADQ DWKPRIV*YLSHLFLCYA*LFCPPNQKA*PL*EA LY*Q*LQF*L*K*FRIIKDSRFE*HDCL*SR*P CTVCA*QLQGSNLAPDYYVELCRCFLQTCLDPK QSQ**PCISGNHKSTMYPCVCIYMYVCIYFQTVI *YLNIPTAIFVTEKLHMRKRLRIFQ*RKNNTWA ICHVSQQFSFFS*FV*RGMCLLNVKGFHCSISL CKSFP*GNKPSAKSHTGVGGFSCTGSCYETMMEH *ACSINVQMVE

Frame 1

YLVLLMGRPVWAQLPREVVGSSGLLGRCLCH*R PGMRWFLPWTLAAVTAAAASTVLATALSPAPTT MDFTPAPLEDTSSRPQFCKWPCECPPSPPRCPLG VSLITDGCECCKMCAQQLGDNCTEAAICDPHRG LYCDYSGDRPRYAIGVCARREEVSGCVPARGIH ELHTCGLHQHTLLSTQVLWSLHGQ*VLHPLQV*D YRRVLPVS*WAWLLPPGPMD*CLLL*PEL*ESQ *HLC*LGILP*LLRNCQLGRHKSWVLGTNPMPV KQSALMANNFSPMSLSYPDLDPWPPFLSLTIQMT PDGAAQAHAMSFLLDIIQHLL*RKMPVSSCSGL HPSLIQPFQVTRSPAGSCLNPKKWNQVDF*YH* FLL*MPNHKTLWVHSDE*MEFGTIE*SIIWSLPR GTVMGNSDVSAPKLS*FQICMHLKVIKHLPSEL NSCLILIFNGKLYPLTWALLRLSFSSPLHCEGY RLGLSQSEIKFDKHSC*WEKPPVNTPETGKGQPV SEGPIDSHTESAADWQGFGQLARLFLESSPLSC LGFIGIGKASGLACLAPESGALEHSSTLTEP*E TQLQTMPDPLK*PRQVQVGVWVKPRSGCPW*QPG VTSRAGGCGTPGAPVFRTHLLQRLISQPFVLLT KWPVFW*EDGGLPVV*KQK*T**RFKAEEVEAK RKRLLLMNIRLLFIVLGKYNIYC*NSFI*GLFCA RHCSQCFACISSLNLHDNVEKFPLLFLFLQM*N GSS*R*ENSTRVTQLVTGKVRIQIEIGLSL*PI FSPCF*SFQMCQNRKTLQ*MA*FFNVIFPSYSLS SSFSKDENI*FSDNLGA*ASKIHGTHKNPGIPC SLFPLSHRNQLSSHI*KMILFTQCCILNVV*LF TGNSVQCAERFLNGKRTGNTSSLL*PPQNLVQCK VYSGAH*ILDEYRKLCMCSYFYSKLSSSKAT*K *NFNSQNFILSALAKETFNISKKCICMYTYICV CVCKNSCIKRIHSMNDLFCKSV*IMLDFLRVKTP AIYKLQGWITAHSI*NSVETQELGSY*ICISIW ETELSFQRS*EVWLEKLGIILAMGAGRWSE*PS RHWF*ETELSYAEPGGQVSDPWVEAMEKEIWIQC NEALSKSEFPCNGVA*FNKN*E**I*WKKISTD *VFTWCQALC*VVHYFI*LLQQF*VCIFHYFIS GKEKCPQKVRAQTAAYSTSPCSCGGLWKRPE*HL LENYIYKGLQTDQIDHHLCGPLLTICSETKESY PKG*LTFAEEIYIHT*SELLRCA*VCKREGDLN SPS*ILLNLIISIF*ALSIHQALWKVLSCHISFN PHSKPIEYGIII*VSQKFSRVLKVLPASEQQTK TGNPG*SDT*AISSCATPSYSVPQIKRHDLYKR RFTDNSCNFNFENDSELSKIVDSNDMIVYNLASL VLCVHSNYREVI*LLTIMLNYVAAFYKLVLIQS SHNDNPAYLGIISQLCIPVCVYICMYVSIFKL* FNI*IFLLPFL*LKNYT*GNVLEFSNRGKITLGQ SVMFHNSSHFSHDLCSVECVCSM*RVFIAQFLC VSLFLKVINHQQSHILELVAFLVQAVVMRQ*WS IEHVQ*MCRWWK

Frame 2

IWCS*WAGQSGPSSPERWSDPLGCSVDACATDV QA*GGSCPGRWQQ*QQQPPAPSWPRPSLQPLRP WTLPQLHWRTPPHAPNSASGHVSARHPHPAARW GSASSQMAVSAVRCALSSLGTTARRLPSVTPTGA STVTTAGTARGTQ*ECVHAGKKCLAVYQPEASM NFTLAGCISTRSYQPKYCGVCMDNRCCIPYKSK TIDVSFQCPDGLGFSRQVLWINACFCNLSCRNPN DIFADLESYPDFSEIAN*AGTNLGSWGLTQCL* SSQPLWPITFHQ*ALVTLIWTLGLHFCL*PFK* RLMVLLRPML*VFSLISFSIYSKEKCLSLAVLDY TQA*SSLSKSLEVLLDLA*IPRNGIR*TFNITN FFFRCQTTRLFGSIQMNRWNLEQ*NNLLFGACQ EVL*WVILTSAHQNYPDSKYVCTSRSSNICQVS* IVA*F*FLMESCIH*PGHC*G*VSLHPYTVKGT D*VCPSQK*NLINIPVDGKSPQLILQRQGKVSP FQKDQLTLTLNQLLTGRALGSWPGSSLNLLPCPA WGS*ELVRPLDWPVWPLRVVPWNTPLLLQSLER PSCRPCQTH*NDQDRFR*GCGSNQEVGALGSSL G*PLELEAVGLQGPPCSGHIYCRDSFHSLSFC*P NGQFSGRKMEVYRLFRNRNRLNKGLKLKRLKLK GKGCC**ISGYYLLY*ENIIFTVRILLFRAFSV PDIALSALHVLAH*IFTTMLRSSHYYFCSYKCET EAHRGEKTQPESPSW*LGKLGFRSKLDCLYNPY FPPVFRASKCVRIGKHCNKWLDFLMSFFPLIVF LAPFQKTRISDFLII*VLKHPKYMGHTKIQESPV AYSLFPIGTSSHHTFKR*FCLPNAAY*MLCSYS QGILCSVQRDS*TGKGLGIHPPYCDLPKT*SSA RYTVVLIKYLMNTGSCACVPTFIRSSLLPKLHEN RILTVKILY*VP*QKRHLIFQRNAYVCIHIFVY AYARILV*REFTP*MISSVSQCESC*IF*E*KH LPSTNYKAG*QLTPFEIQWKPKS*VLTEFASQFG KLNLAFKDHRKSGWRN*GLFWQWVQEGGQNNPV AIGFEKRNYLMQSPEGKSQTHGLKPWRRKFGSN VMKRFLSQNFPAMVWPDSIKIKNNKYNGKKSPLI ECLLGAKHYAKLFIILFNCYSNFEYASFTIL*V EKRSAPKKLELKQQLILPAPALAEASGKDLNDT YWRITSTRGFKQTK*IITSVVPC*LYVLRQRKAT LRVS*PLLRKFTFILRVNYSGVLRCAKGKET*I HQVKSC*TLS*AFFERLAYTKPCGRCFPAISHL ILTANL*NMALSSESHRSLVVYSRSYQLVNSRPR LETQDSLIPEPSLLVLRLVILSPKSKGMTFIRG ALLTIAAILTLKMIQNYQR**IRMT*LSIISLA LYCVCIAITGK*SSS*LLC*TMSLLFTNLS*SKA VTMITLHIWES*VNYVSLCVYIYVCMYLFSNCD LIFKYSYCHFCD*KTTHEETS*NFPIEEK*HLG NLSCFTTVLIFLMICVAWNVFAQCEGFSLLNFSV *VFSLR**TISKVTYWSWWLFLYRQLL*DNDGA LSMFNKCADGG

Sequence WISP1.aAug05

ATATCTGGTGCTCCTGATGGGCCGGCCAGTCTGGGCCCAGCTCCCCCGAGAGGTGGTCGGATCCTCTGGGCTGCTCGGTCGATGCCTGTGCCACTGACGT CCAGGCATGAGGTGGTTCCTGCCCTGGACGCTGGCAGCAGTGACAGCAGCAGCCGCCAGCACCGTCCTGGCCACGGCCCTCTCTCCAGCCCCTACGACCA TGGACTTTACCCCAGCTCCACTGGAGGACACCTCCTCACGCCCCCAATTCTGCAAGTGGCCATGTGAGTGCCCGCCATCCCCACCCCGCTGCCCGCTGGG GGTCAGCCTCATCACAGATGGCTGTGAGTGCTGTAAGATGTGCGCTCAGCAGCTTGGGGACAACTGCACGGAGGCTGCCATCTGTGACCCCCACCGGGGC CTCTACTGTGACTACAGCGGGGACCGCCCGAGGTACGCAATAGGAGTGTGTGCACAGGTGGTCGGTGTGGGCTGCGTCCTGGATGGGGTGCGCTACAACA ACGGCCAGTCCTTCCAGCCTAACTGCAAGTACAACTGCACGTGCATCGACGGCGCGGTGGGCTGCACACCACTGTGCCTCCGAGTGCGCCCCCCGCGTCT CTGGTGCCCCCACCCGCGGCGCGTGAGCATACCTGGCCACTGCTGTGAGCAGTGGGTATGTGAGGACGACGCCAAGAGGCCACGCAAGACCGCACCCCGT GACACAGGAGCCTTCGATGCTGTGGGTGAGGTGGAGGCATGGCACAGGAACTGCATAGCCTACACAAGCCCCTGGAGCCCTTGCTCCACCAGCTGCGGCC TGGGGGTCTCCACTCGGATCTCCAATGTTAACGCCCAGTGCTGGCCTGAGCAAGAGAGCCGCCTCTGCAACTTGCGGCCATGCGATGTGGACATCCATAC ACTCATTAAGGCAGGGAAGAAGTGTCTGGCTGTGTACCAGCCAGAGGCATCCATGAACTTCACACTTGCGGGCTGCATCAGCACACGCTCCTATCAACCC AAGTACTGTGGAGTTTGCATGGACAATAGGTGCTGCATCCCCTACAAGTCTAAGACTATCGACGTGTCCTTCCAGTGTCCTGATGGGCTTGGCTTCTCCC GCCAGGTCCTATGGATTAATGCCTGCTTCTGTAACCTGAGCTGTAGGAATCCCAATGACATCTTTGCTGACTTGGAATCCTACCCTGACTTCTCAGAAAT TGCCAACTAGGCAGGCACAAATCTTGGGTCTTGGGGACTAACCCAATGCCTGTGAAGCAGTCAGCCCTTATGGCCAATAACTTTTCACCAATGAGCCTTA GTTACCCTGATCTGGACCCTTGGCCTCCATTTCTGTCTCTAACCATTCAAATGACGCCTGATGGTGCTGCTCAGGCCCATGCTATGAGTTTTCTCCTTGA TATCATTCAGCATCTACTCTAAAGAAAAATGCCTGTCTCTAGCTGTTCTGGACTACACCCAAGCCTGATCCAGCCTTTCCAAGTCACTAGAAGTCCTGCT GGATCTTGCCTAAATCCCAAGAAATGGAATCAGGTAGACTTTTAATATCACTAATTTCTTCTTTAGATGCCAAACCACAAGACTCTTTGGGTCCATTCAG ATGAATAGATGGAATTTGGAACAATAGAATAATCTATTATTTGGAGCCTGCCAAGAGGTACTGTAATGGGTAATTCTGACGTCAGCGCACCAAAACTATC CTGATTCCAAATATGTATGCACCTCAAGGTCATCAAACATTTGCCAAGTGAGTTGAATAGTTGCTTAATTTTGATTTTTAATGGAAAGTTGTATCCATTA ACCTGGGCATTGTTGAGGTTAAGTTTCTCTTCACCCCTACACTGTGAAGGGTACAGATTAGGTTTGTCCCAGTCAGAAATAAAATTTGATAAACATTCCT GTTGATGGGAAAAGCCCCCAGTTAATACTCCAGAGACAGGGAAAGGTCAGCCCGTTTCAGAAGGACCAATTGACTCTCACACTGAATCAGCTGCTGACTG GCAGGGCTTTGGGCAGTTGGCCAGGCTCTTCCTTGAATCTTCTCCCTTGTCCTGCTTGGGGTTCATAGGAATTGGTAAGGCCTCTGGACTGGCCTGTCTG GCCCCTGAGAGTGGTGCCCTGGAACACTCCTCTACTCTTACAGAGCCTTGAGAGACCCAGCTGCAGACCATGCCAGACCCACTGAAATGACCAAGACAGG TTCAGGTAGGGGTGTGGGTCAAACCAAGAAGTGGGTGCCCTTGGTAGCAGCCTGGGGTGACCTCTAGAGCTGGAGGCTGTGGGACTCCAGGGGCCCCCGT GTTCAGGACACATCTATTGCAGAGACTCATTTCACAGCCTTTCGTTCTGCTGACCAAATGGCCAGTTTTCTGGTAGGAAGATGGAGGTTTACCGGTTGTT TAGAAACAGAAATAGACTTAATAAAGGTTTAAAGCTGAAGAGGTTGAAGCTAAAAGGAAAAGGTTGTTGTTAATGAATATCAGGCTATTATTTATTGTAT TAGGAAAATATAATATTTACTGTTAGAATTCTTTTATTTAGGGCCTTTTCTGTGCCAGACATTGCTCTCAGTGCTTTGCATGTATTAGCTCACTGAATCT TCACGACAATGTTGAGAAGTTCCCATTATTATTTCTGTTCTTACAAATGTGAAACGGAAGCTCATAGAGGTGAGAAAACTCAACCAGAGTCACCCAGTTG GTGACTGGGAAAGTTAGGATTCAGATCGAAATTGGACTGTCTTTATAACCCATATTTTCCCCCTGTTTTTAGAGCTTCCAAATGTGTCAGAATAGGAAAA CATTGCAATAAATGGCTTGATTTTTTAATGTCATTTTTCCCTCTTATAGTCTTTCTAGCTCCTTTTCAAAAGACGAGAATATCTGATTTTCTGATAATTT AGGTGCTTAAGCATCCAAAATACATGGGACACACAAAAATCCAGGAATCCCCTGTAGCTTATTCCCTCTTTCCCATCGGAACCAGCTCTCATCACACATT TAAAAGATGATTCTGTTTACCCAATGCTGCATATTGAATGTTGTGTAGTTATTCACAGGGAATTCTGTGCAGTGTGCAGAGAGATTCCTAAACGGGAAAA GGACTGGGAATACATCCTCCTTACTGTGACCTCCCCAAAACCTAGTCCAGTGCAAGGTATACAGTGGTGCTCATTAAATACTTGATGAATACAGGAAGCT GTGCATGTGTTCCTACTTTTATTCGAAGCTCTCTTCTTCCAAAGCTACATGAAAATAGAATTTTAACAGTCAAAATTTTATATTAAGTGCCTTAGCAAAA GAGACATTTAATATTTCAAAGAAATGCATATGTATGTATACATATATTTGTGTATGCGTATGCAAGAATTCTTGTATAAAGAGAATTCACTCCATGAATG ATCTCTTCTGTAAGTCAGTGTGAATCATGTTAGATTTTCTGAGAGTGAAAACACCTGCCATCTACAAATTACAAGGCTGGATAACAGCTCACTCCATTTG AAATTCAGTGGAAACCCAAGAGCTAGGTTCTTACTGAATTTGCATCTCAATTTGGGAAACTGAACTTAGCTTTCAAAGATCATAGGAAGTCTGGTTGGAG AAACTAGGGATTATTCTGGCAATGGGTGCAGGAAGGTGGTCAGAATAACCCAGTCGCCATTGGTTTTGAGAAACGGAACTATCTTATGCAGAGCCCGGAG GGCAAGTCTCAGACCCATGGGTTGAAGCCATGGAGAAGGAAATTTGGATCCAATGTAATGAAGCGCTTTCTAAGTCAGAATTTCCCTGCAATGGTGTGGC CTGATTCAATAAAAATTAAGAATAATAAATATAATGGAAAAAAATCTCCACTGATTGAGTGTTTACTTGGTGCCAAGCACTATGCTAAGTTGTTCATTAT TTTATTTAATTGTTACAGCAATTTTGAGTATGCATCTTTCACTATTTTATAAGTGGAAAAGAGAAGTGCCCCCAAAAAGTTAGAGCTCAAACAGCAGCTT ATTCTACCAGCCCCTGCTCTTGCGGAGGCCTCTGGAAAAGACCTGAATGACACCTATTGGAGAATTACATCTACAAGGGGCTTCAAACAGACCAAATAGA TCATCACCTCTGTGGTCCCTTGTTAACTATATGTTCTGAGACAAAGGAAAGCTACCCTAAGGGTTAGTTAACCTTTGCTGAGGAAATTTACATTCATACT TAGAGTGAATTACTCAGGTGTGCTTAGGTGTGCAAAAGGGAAGGAGACCTGAATTCACCAAGTTAAATCTTGCTAAACCTTATCATAAGCATTTTTTGAG CGCTTAGCATACACCAAGCCTTGTGGAAGGTGCTTTCCTGCCATATCTCATTTAATCCTCACAGCAAACCTATAGAATATGGCATTATCATCTGAGTCTC ACAGAAGTTTAGTCGTGTACTCAAGGTCTTACCAGCTAGTGAACAGCAGACCAAGACTGGAAACCCAGGATAGTCTGATACCTGAGCCATCTCTTCTTGT GCTACGCCTAGTTATTCTGTCCCCCAAATCAAAAGGCATGACCTTTATAAGAGGCGCTTTACTGACAATAGCTGCAATTTTAACTTTGAAAATGATTCAG AATTATCAAAGATAGTAGATTCGAATGACATGATTGTCTATAATCTCGCTAGCCTTGTACTGTGTGTGCATAGCAATTACAGGGAAGTAATCTAGCTCCT GACTATTATGTTGAACTATGTCGCTGCTTTTTACAAACTTGTCTTGATCCAAAGCAGTCACAATGATAACCCTGCATATCTGGGAATCATAAGTCAACTA TGTATCCCTGTGTGTGTATATATATGTATGTATGTATCTATTTTCAAACTGTGATTTAATATTTAAATATTCCTACTGCCATTTTTGTGACTGAAAAACT ACACATGAGGAAACGTCTTAGAATTTTCCAATAGAGGAAAAATAACACTTGGGCAATCTGTCATGTTTCACAACAGTTCTCATTTTTCTCATGATTTGTG TAGCGTGGAATGTGTTTGCTCAATGTGAAGGGTTTTCATTGCTCAATTTCTCTGTGTAAGTCTTTTCCTTAAGGTAATAAACCATCAGCAAAGTCACATA CTGGAGTTGGTGGCTTTTCTTGTACAGGCAGTTGTTATGAGACAATGATGGAGCATTGAGCATGTTCAATAAATGTGCAGATGGTGGAAA

WISP1.u.f.4 (forward primer)
WISP1.u.r.4 (reverse primer)
Multiple exon skipping

Frame 0

ISGAPDGPASLGPAPPRGGRILWAARSMPVPLT SRHEVVPALDAGSSDSSSRQHRPGHGPLSSPYDH GLYPSSTGGHLLTPPILQVAM*VPAIPTPLPAG GQPHHRWL*VL*DVRSAAWGQLHGGCHL*PPPG PLL*LQRGPPEVRNRSVCTGGRCGLRPGWGALQQ RPVLPA*LQVQLHVHRRRGGLHTTVPPSAPPAS LVPPPAAREHTWPLL*AVGM*GRRQEATQDRTP *HRSLRCCG*GGGMAQELHSLHKPLEPLLHQLRP GGLHSDLQC*RPVLA*AREPPLQLAAMRCGHPY TH*GREEVSGCVPARGIHELHTCGLHQHTLLST QVLWSLHGQ*VLHPLQV*DYRRVLPVS*WAWLLP PGPMD*CLLL*PEL*ESQ*HLC*LGILP*LLRN CQLGRHKSWVLGTNPMPVKQSALMANNFSPMSL SYPDLDPWPPFLSLTIQMTPDGAAQAHAMSFLLD IIQHLL*RKMPVSSCSGLHPSLIQPFQVTRSPA GSCLNPKKWNQVDF*YH*FLL*MPNHKTLWVHS DE*MEFGTIE*SIIWSLPRGTVMGNSDVSAPKLS *FQICMHLKVIKHLPSELNSCLILIFNGKLYPL TWALLRLSFSSPLHCEGYRLGLSQSEIKFDKHS C*WEKPPVNTPETGKGQPVSEGPIDSHTESAADW QGFGQLARLFLESSPLSCLGFIGIGKASGLACL APESGALEHSSTLTEP*ETQLQTMPDPLK*PRQ VQVGVWVKPRSGCPW*QPGVTSRAGGCGTPGAPV FRTHLLQRLISQPFVLLTKWPVFW*EDGGLPVV *KQK*T**RFKAEEVEAKRKRLLLMNIRLLFIV LGKYNIYC*NSFI*GLFCARHCSQCFACISSLNL HDNVEKFPLLFLFLQM*NGSS*R*ENSTRVTQL VTGKVRIQIEIGLSL*PIFSPCF*SFQMCQNRK TLQ*MA*FFNVIFPSYSLSSSFSKDENI*FSDNL GA*ASKIHGTHKNPGIPCSLFPLSHRNQLSSHI *KMILFTQCCILNVV*LFTGNSVQCAERFLNGK RTGNTSSLL*PPQNLVQCKVYSGAH*ILDEYRKL CMCSYFYSKLSSSKAT*K*NFNSQNFILSALAK ETFNISKKCICMYTYICVCVCKNSCIKRIHSMN DLFCKSV*IMLDFLRVKTPAIYKLQGWITAHSI* NSVETQELGSY*ICISIWETELSFQRS*EVWLE KLGIILAMGAGRWSE*PSRHWF*ETELSYAEPG GQVSDPWVEAMEKEIWIQCNEALSKSEFPCNGVA *FNKN*E**I*WKKISTD*VFTWCQALC*VVHY FI*LLQQF*VCIFHYFISGKEKCPQKVRAQTAA YSTSPCSCGGLWKRPE*HLLENYIYKGLQTDQID HHLCGPLLTICSETKESYPKG*LTFAEEIYIHT *SELLRCA*VCKREGDLNSPS*ILLNLIISIF* ALSIHQALWKVLSCHISFNPHSKPIEYGIII*VS QKFSRVLKVLPASEQQTKTGNPG*SDT*AISSC ATPSYSVPQIKRHDLYKRRFTDNSCNFNFENDS ELSKIVDSNDMIVYNLASLVLCVHSNYREVI*LL TIMLNYVAAFYKLVLIQSSHNDNPAYLGIISQL CIPVCVYICMYVSIFKL*FNI*IFLLPFL*LKN YT*GNVLEFSNRGKITLGQSVMFHNSSHFSHDLC SVECVCSM*RVFIAQFLCVSLFLKVINHQQSHI LELVAFLVQAVVMRQ*WSIEHVQ*MCRWWK

Frame 1

YLVLLMGRPVWAQLPREVVGSSGLLGRCLCH*R PGMRWFLPWTLAAVTAAAASTVLATALSPAPTT MDFTPAPLEDTSSRPQFCKWPCECPPSPPRCPLG VSLITDGCECCKMCAQQLGDNCTEAAICDPHRG LYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYN NGQSFQPNCKYNCTCIDGAVGCTPLCLRVRPPRL WCPHPRRVSIPGHCCEQWVCEDDAKRPRKTAPR DTGAFDAVGEVEAWHRNCIAYTSPWSPCSTSCG LGVSTRISNVNAQCWPEQESRLCNLRPCDVDIHT LIKAGKKCLAVYQPEASMNFTLAGCISTRSYQP KYCGVCMDNRCCIPYKSKTIDVSFQCPDGLGFS RQVLWINACFCNLSCRNPNDIFADLESYPDFSEI AN*AGTNLGSWGLTQCL*SSQPLWPITFHQ*AL VTLIWTLGLHFCL*PFK*RLMVLLRPML*VFSL ISFSIYSKEKCLSLAVLDYTQA*SSLSKSLEVLL DLA*IPRNGIR*TFNITNFFFRCQTTRLFGSIQ MNRWNLEQ*NNLLFGACQEVL*WVILTSAHQNY PDSKYVCTSRSSNICQVS*IVA*F*FLMESCIH* PGHC*G*VSLHPYTVKGTD*VCPSQK*NLINIP VDGKSPQLILQRQGKVSPFQKDQLTLTLNQLLT GRALGSWPGSSLNLLPCPAWGS*ELVRPLDWPVW PLRVVPWNTPLLLQSLERPSCRPCQTH*NDQDR FR*GCGSNQEVGALGSSLG*PLELEAVGLQGPP CSGHIYCRDSFHSLSFC*PNGQFSGRKMEVYRLF RNRNRLNKGLKLKRLKLKGKGCC**ISGYYLLY *ENIIFTVRILLFRAFSVPDIALSALHVLAH*I FTTMLRSSHYYFCSYKCETEAHRGEKTQPESPSW *LGKLGFRSKLDCLYNPYFPPVFRASKCVRIGK HCNKWLDFLMSFFPLIVFLAPFQKTRISDFLII *VLKHPKYMGHTKIQESPVAYSLFPIGTSSHHTF KR*FCLPNAAY*MLCSYSQGILCSVQRDS*TGK GLGIHPPYCDLPKT*SSARYTVVLIKYLMNTGS CACVPTFIRSSLLPKLHENRILTVKILY*VP*QK RHLIFQRNAYVCIHIFVYAYARILV*REFTP*M ISSVSQCESC*IF*E*KHLPSTNYKAG*QLTPF EIQWKPKS*VLTEFASQFGKLNLAFKDHRKSGWR N*GLFWQWVQEGGQNNPVAIGFEKRNYLMQSPE GKSQTHGLKPWRRKFGSNVMKRFLSQNFPAMVW PDSIKIKNNKYNGKKSPLIECLLGAKHYAKLFII LFNCYSNFEYASFTIL*VEKRSAPKKLELKQQL ILPAPALAEASGKDLNDTYWRITSTRGFKQTK* IITSVVPC*LYVLRQRKATLRVS*PLLRKFTFIL RVNYSGVLRCAKGKET*IHQVKSC*TLS*AFFE RLAYTKPCGRCFPAISHLILTANL*NMALSSES HRSLVVYSRSYQLVNSRPRLETQDSLIPEPSLLV LRLVILSPKSKGMTFIRGALLTIAAILTLKMIQ NYQR**IRMT*LSIISLALYCVCIAITGK*SSS *LLC*TMSLLFTNLS*SKAVTMITLHIWES*VNY VSLCVYIYVCMYLFSNCDLIFKYSYCHFCD*KT THEETS*NFPIEEK*HLGNLSCFTTVLIFLMIC VAWNVFAQCEGFSLLNFSV*VFSLR**TISKVTY WSWWLFLYRQLL*DNDGALSMFNKCADGG

Frame 2

IWCS*WAGQSGPSSPERWSDPLGCSVDACATDV QA*GGSCPGRWQQ*QQQPPAPSWPRPSLQPLRP WTLPQLHWRTPPHAPNSASGHVSARHPHPAARW GSASSQMAVSAVRCALSSLGTTARRLPSVTPTGA STVTTAGTARGTQ*ECVHRWSVWAASWMGCATT TASPSSLTASTTARASTARWAAHHCASECAPRV SGAPTRGA*AYLATAVSSGYVRTTPRGHARPHPV TQEPSMLWVRWRHGTGTA*PTQAPGALAPPAAA WGSPLGSPMLTPSAGLSKRAASATCGHAMWTSI HSLRQGRSVWLCTSQRHP*TSHLRAASAHAPINP STVEFAWTIGAASPTSLRLSTCPSSVLMGLASP ARSYGLMPASVT*AVGIPMTSLLTWNPTLTSQK LPTRQAQILGLGD*PNACEAVSPYGQ*LFTNEP* LP*SGPLASISVSNHSNDA*WCCSGPCYEFSP* YHSASTLKKNACL*LFWTTPKPDPAFPSH*KSC WILPKSQEMESGRLLISLISSLDAKPQDSLGPFR *IDGIWNNRIIYYLEPAKRYCNG*F*RQRTKTI LIPNMYAPQGHQTFAK*VE*LLNFDF*WKVVSI NLGIVEVKFLFTPTL*RVQIRFVPVRNKI**TFL LMGKAPS*YSRDRERSARFRRTN*LSH*ISC*L AGLWAVGQALP*IFSLVLLGVHRNW*GLWTGLS GP*EWCPGTLLYSYRALRDPAADHARPTEMTKTG SGRGVGQTKKWVPLVAAWGDL*SWRLWDSRGPR VQDTSIAETHFTAFRSADQMASFLVGRWRFTGC LETEIDLIKV*S*RG*S*KEKVVVNEYQAIIYCI RKI*YLLLEFFYLGPFLCQTLLSVLCMY*LTES SRQC*EVPIIISVLTNVKRKLIEVRKLNQSHPV GDWES*DSDRNWTVFITHIFPLFLELPNVSE*EN IAINGLIF*CHFSLL*SF*LLFKRREYLIF**F RCLSIQNTWDTQKSRNPL*LIPSFPSEPALITH LKDDSVYPMLHIECCVVIHREFCAVCREIPKREK DWEYILLTVTSPKPSPVQGIQWCSLNT**IQEA VHVFLLLFEALFFQSYMKIEF*QSKFYIKCLSK RDI*YFKEMHMYVYIYLCMRMQEFLYKENSLHE* SLL*VSVNHVRFSESENTCHLQITRLDNSSLHL KFSGNPRARFLLNLHLNLGN*T*LSKIIGSLVG ETRDYSGNGCRKVVRITQSPLVLRNGTILCRARR ASLRPMG*SHGEGNLDPM**SAF*VRISLQWCG LIQ*KLRIINIMEKNLH*LSVYLVPSTMLSCSL FYLIVTAILSMHLSLFYKWKREVPPKS*SSNSSL FYQPLLLRRPLEKT*MTPIGELHLQGASNRPNR SSPLWSLVNYMF*DKGKLP*GLVNLC*GNLHSY LE*ITQVCLGVQKGRRPEFTKLNLAKPYHKHFLS A*HTPSLVEGAFLPYLI*SSQQTYRIWHYHLSL TEV*SCTQGLTS**TADQDWKPRIV*YLSHLFL CYA*LFCPPNQKA*PL*EALY*Q*LQF*L*K*FR IIKDSRFE*HDCL*SR*PCTVCA*QLQGSNLAP DYYVELCRCFLQTCLDPKQSQ**PCISGNHKST MYPCVCIYMYVCIYFQTVI*YLNIPTAIFVTEKL HMRKRLRIFQ*RKNNTWAICHVSQQFSFFS*FV *RGMCLLNVKGFHCSISLCKSFP*GNKPSAKSH TGVGGFSCTGSCYETMMEH*ACSINVQMVE