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Sequence WISP1.cAug05
ATATCTGGTGCTCCTGATGGGCCGGCCAGTCTGGGCCCAGCTCCCCCGAGAGGTGGTCGGATCCTCTGGGCTGCTCGGTCGATGCCTGTGCCACTGACGTCCAGGCATGAGGTGGTTCCTGCCCTGGACGCTGGCAGCAGTGACAGCAGCAGCCGCCAGCACCGTCCTGGCCACGATGCTGTGGGTGAGGTGGAGGCATG
GCACAGGAACTGCATAGCCTACACAAGCCCCTGGAGCCCTTGCTCCACCAGCTGCGGCCTGGGGGTCTCCACTCGGATCTCCAATGTTAACGCCCAGTGC
TGGCCTGAGCAAGAGAGCCGCCTCTGCAACTTGCGGCCATGCGATGTGGACATCCATACACTCATTAAGGCAGGGAAGAAGTGTCTGGCTGTGTACCAGC
CAGAGGCATCCATGAACTTCACACTTGCGGGCTGCATCAGCACACGCTCCTATCAACCCAAGTACTGTGGAGTTTGCATGGACAATAGGTGCTGCATCCC
CTACAAGTCTAAGACTATCGACGTGTCCTTCCAGTGTCCTGATGGGCTTGGCTTCTCCCGCCAGGTCCTATGGATTAATGCCTGCTTCTGTAACCTGAGC
TGTAGGAATCCCAATGACATCTTTGCTGACTTGGAATCCTACCCTGACTTCTCAGAAATTGCCAACTAGGCAGGCACAAATCTTGGGTCTTGGGGACTAA
CCCAATGCCTGTGAAGCAGTCAGCCCTTATGGCCAATAACTTTTCACCAATGAGCCTTAGTTACCCTGATCTGGACCCTTGGCCTCCATTTCTGTCTCTA
ACCATTCAAATGACGCCTGATGGTGCTGCTCAGGCCCATGCTATGAGTTTTCTCCTTGATATCATTCAGCATCTACTCTAAAGAAAAATGCCTGTCTCTA
GCTGTTCTGGACTACACCCAAGCCTGATCCAGCCTTTCCAAGTCACTAGAAGTCCTGCTGGATCTTGCCTAAATCCCAAGAAATGGAATCAGGTAGACTT
TTAATATCACTAATTTCTTCTTTAGATGCCAAACCACAAGACTCTTTGGGTCCATTCAGATGAATAGATGGAATTTGGAACAATAGAATAATCTATTATT
TGGAGCCTGCCAAGAGGTACTGTAATGGGTAATTCTGACGTCAGCGCACCAAAACTATCCTGATTCCAAATATGTATGCACCTCAAGGTCATCAAACATT
TGCCAAGTGAGTTGAATAGTTGCTTAATTTTGATTTTTAATGGAAAGTTGTATCCATTAACCTGGGCATTGTTGAGGTTAAGTTTCTCTTCACCCCTACA
CTGTGAAGGGTACAGATTAGGTTTGTCCCAGTCAGAAATAAAATTTGATAAACATTCCTGTTGATGGGAAAAGCCCCCAGTTAATACTCCAGAGACAGGG
AAAGGTCAGCCCGTTTCAGAAGGACCAATTGACTCTCACACTGAATCAGCTGCTGACTGGCAGGGCTTTGGGCAGTTGGCCAGGCTCTTCCTTGAATCTT
CTCCCTTGTCCTGCTTGGGGTTCATAGGAATTGGTAAGGCCTCTGGACTGGCCTGTCTGGCCCCTGAGAGTGGTGCCCTGGAACACTCCTCTACTCTTAC
AGAGCCTTGAGAGACCCAGCTGCAGACCATGCCAGACCCACTGAAATGACCAAGACAGGTTCAGGTAGGGGTGTGGGTCAAACCAAGAAGTGGGTGCCCT
TGGTAGCAGCCTGGGGTGACCTCTAGAGCTGGAGGCTGTGGGACTCCAGGGGCCCCCGTGTTCAGGACACATCTATTGCAGAGACTCATTTCACAGCCTT
TCGTTCTGCTGACCAAATGGCCAGTTTTCTGGTAGGAAGATGGAGGTTTACCGGTTGTTTAGAAACAGAAATAGACTTAATAAAGGTTTAAAGCTGAAGA
GGTTGAAGCTAAAAGGAAAAGGTTGTTGTTAATGAATATCAGGCTATTATTTATTGTATTAGGAAAATATAATATTTACTGTTAGAATTCTTTTATTTAG
GGCCTTTTCTGTGCCAGACATTGCTCTCAGTGCTTTGCATGTATTAGCTCACTGAATCTTCACGACAATGTTGAGAAGTTCCCATTATTATTTCTGTTCT
TACAAATGTGAAACGGAAGCTCATAGAGGTGAGAAAACTCAACCAGAGTCACCCAGTTGGTGACTGGGAAAGTTAGGATTCAGATCGAAATTGGACTGTC
TTTATAACCCATATTTTCCCCCTGTTTTTAGAGCTTCCAAATGTGTCAGAATAGGAAAACATTGCAATAAATGGCTTGATTTTTTAATGTCATTTTTCCC
TCTTATAGTCTTTCTAGCTCCTTTTCAAAAGACGAGAATATCTGATTTTCTGATAATTTAGGTGCTTAAGCATCCAAAATACATGGGACACACAAAAATC
CAGGAATCCCCTGTAGCTTATTCCCTCTTTCCCATCGGAACCAGCTCTCATCACACATTTAAAAGATGATTCTGTTTACCCAATGCTGCATATTGAATGT
TGTGTAGTTATTCACAGGGAATTCTGTGCAGTGTGCAGAGAGATTCCTAAACGGGAAAAGGACTGGGAATACATCCTCCTTACTGTGACCTCCCCAAAAC
CTAGTCCAGTGCAAGGTATACAGTGGTGCTCATTAAATACTTGATGAATACAGGAAGCTGTGCATGTGTTCCTACTTTTATTCGAAGCTCTCTTCTTCCA
AAGCTACATGAAAATAGAATTTTAACAGTCAAAATTTTATATTAAGTGCCTTAGCAAAAGAGACATTTAATATTTCAAAGAAATGCATATGTATGTATAC
ATATATTTGTGTATGCGTATGCAAGAATTCTTGTATAAAGAGAATTCACTCCATGAATGATCTCTTCTGTAAGTCAGTGTGAATCATGTTAGATTTTCTG
AGAGTGAAAACACCTGCCATCTACAAATTACAAGGCTGGATAACAGCTCACTCCATTTGAAATTCAGTGGAAACCCAAGAGCTAGGTTCTTACTGAATTT
GCATCTCAATTTGGGAAACTGAACTTAGCTTTCAAAGATCATAGGAAGTCTGGTTGGAGAAACTAGGGATTATTCTGGCAATGGGTGCAGGAAGGTGGTC
AGAATAACCCAGTCGCCATTGGTTTTGAGAAACGGAACTATCTTATGCAGAGCCCGGAGGGCAAGTCTCAGACCCATGGGTTGAAGCCATGGAGAAGGAA
ATTTGGATCCAATGTAATGAAGCGCTTTCTAAGTCAGAATTTCCCTGCAATGGTGTGGCCTGATTCAATAAAAATTAAGAATAATAAATATAATGGAAAA
AAATCTCCACTGATTGAGTGTTTACTTGGTGCCAAGCACTATGCTAAGTTGTTCATTATTTTATTTAATTGTTACAGCAATTTTGAGTATGCATCTTTCA
CTATTTTATAAGTGGAAAAGAGAAGTGCCCCCAAAAAGTTAGAGCTCAAACAGCAGCTTATTCTACCAGCCCCTGCTCTTGCGGAGGCCTCTGGAAAAGA
CCTGAATGACACCTATTGGAGAATTACATCTACAAGGGGCTTCAAACAGACCAAATAGATCATCACCTCTGTGGTCCCTTGTTAACTATATGTTCTGAGA
CAAAGGAAAGCTACCCTAAGGGTTAGTTAACCTTTGCTGAGGAAATTTACATTCATACTTAGAGTGAATTACTCAGGTGTGCTTAGGTGTGCAAAAGGGA
AGGAGACCTGAATTCACCAAGTTAAATCTTGCTAAACCTTATCATAAGCATTTTTTGAGCGCTTAGCATACACCAAGCCTTGTGGAAGGTGCTTTCCTGC
CATATCTCATTTAATCCTCACAGCAAACCTATAGAATATGGCATTATCATCTGAGTCTCACAGAAGTTTAGTCGTGTACTCAAGGTCTTACCAGCTAGTG
AACAGCAGACCAAGACTGGAAACCCAGGATAGTCTGATACCTGAGCCATCTCTTCTTGTGCTACGCCTAGTTATTCTGTCCCCCAAATCAAAAGGCATGA
CCTTTATAAGAGGCGCTTTACTGACAATAGCTGCAATTTTAACTTTGAAAATGATTCAGAATTATCAAAGATAGTAGATTCGAATGACATGATTGTCTAT
AATCTCGCTAGCCTTGTACTGTGTGTGCATAGCAATTACAGGGAAGTAATCTAGCTCCTGACTATTATGTTGAACTATGTCGCTGCTTTTTACAAACTTG
TCTTGATCCAAAGCAGTCACAATGATAACCCTGCATATCTGGGAATCATAAGTCAACTATGTATCCCTGTGTGTGTATATATATGTATGTATGTATCTAT
TTTCAAACTGTGATTTAATATTTAAATATTCCTACTGCCATTTTTGTGACTGAAAAACTACACATGAGGAAACGTCTTAGAATTTTCCAATAGAGGAAAA
ATAACACTTGGGCAATCTGTCATGTTTCACAACAGTTCTCATTTTTCTCATGATTTGTGTAGCGTGGAATGTGTTTGCTCAATGTGAAGGGTTTTCATTG
CTCAATTTCTCTGTGTAAGTCTTTTCCTTAAGGTAATAAACCATCAGCAAAGTCACATACTGGAGTTGGTGGCTTTTCTTGTACAGGCAGTTGTTATGAG
ACAATGATGGAGCATTGAGCATGTTCAATAAATGTGCAGATGGTGGAAA
- WISP1.u.f.1 (forward primer)
- WISP1.u.r.4 (reverse primer)
- Multiple exon skipping
Frame 0
ISGAPDGPASLGPAPPRGGRILWAARSMPVPLTSRHEVVPALDAGSSDSSSRQHRPGHDAVGEVEAW
HRNCIAYTSPWSPCSTSCGLGVSTRISNVNAQC
WPEQESRLCNLRPCDVDIHTLIKAGKKCLAVYQ
PEASMNFTLAGCISTRSYQPKYCGVCMDNRCCIP
YKSKTIDVSFQCPDGLGFSRQVLWINACFCNLS
CRNPNDIFADLESYPDFSEIAN*AGTNLGSWGL
TQCL*SSQPLWPITFHQ*ALVTLIWTLGLHFCL*
PFK*RLMVLLRPML*VFSLISFSIYSKEKCLSL
AVLDYTQA*SSLSKSLEVLLDLA*IPRNGIR*T
FNITNFFFRCQTTRLFGSIQMNRWNLEQ*NNLLF
GACQEVL*WVILTSAHQNYPDSKYVCTSRSSNI
CQVS*IVA*F*FLMESCIH*PGHC*G*VSLHPY
TVKGTD*VCPSQK*NLINIPVDGKSPQLILQRQG
KVSPFQKDQLTLTLNQLLTGRALGSWPGSSLNL
LPCPAWGS*ELVRPLDWPVWPLRVVPWNTPLLL
QSLERPSCRPCQTH*NDQDRFR*GCGSNQEVGAL
GSSLG*PLELEAVGLQGPPCSGHIYCRDSFHSL
SFC*PNGQFSGRKMEVYRLFRNRNRLNKGLKLK
RLKLKGKGCC**ISGYYLLY*ENIIFTVRILLFR
AFSVPDIALSALHVLAH*IFTTMLRSSHYYFCS
YKCETEAHRGEKTQPESPSW*LGKLGFRSKLDC
LYNPYFPPVFRASKCVRIGKHCNKWLDFLMSFFP
LIVFLAPFQKTRISDFLII*VLKHPKYMGHTKI
QESPVAYSLFPIGTSSHHTFKR*FCLPNAAY*M
LCSYSQGILCSVQRDS*TGKGLGIHPPYCDLPKT
*SSARYTVVLIKYLMNTGSCACVPTFIRSSLLP
KLHENRILTVKILY*VP*QKRHLIFQRNAYVCI
HIFVYAYARILV*REFTP*MISSVSQCESC*IF*
E*KHLPSTNYKAG*QLTPFEIQWKPKS*VLTEF
ASQFGKLNLAFKDHRKSGWRN*GLFWQWVQEGG
QNNPVAIGFEKRNYLMQSPEGKSQTHGLKPWRRK
FGSNVMKRFLSQNFPAMVWPDSIKIKNNKYNGK
KSPLIECLLGAKHYAKLFIILFNCYSNFEYASF
TIL*VEKRSAPKKLELKQQLILPAPALAEASGKD
LNDTYWRITSTRGFKQTK*IITSVVPC*LYVLR
QRKATLRVS*PLLRKFTFILRVNYSGVLRCAKG
KET*IHQVKSC*TLS*AFFERLAYTKPCGRCFPA
ISHLILTANL*NMALSSESHRSLVVYSRSYQLV
NSRPRLETQDSLIPEPSLLVLRLVILSPKSKGM
TFIRGALLTIAAILTLKMIQNYQR**IRMT*LSI
ISLALYCVCIAITGK*SSS*LLC*TMSLLFTNL
S*SKAVTMITLHIWES*VNYVSLCVYIYVCMYL
FSNCDLIFKYSYCHFCD*KTTHEETS*NFPIEEK
*HLGNLSCFTTVLIFLMICVAWNVFAQCEGFSL
LNFSV*VFSLR**TISKVTYWSWWLFLYRQLL*
DNDGALSMFNKCADGG
Frame 1
YLVLLMGRPVWAQLPREVVGSSGLLGRCLCH*RPGMRWFLPWTLAAVTAAAASTVLATMLWVRWRH
GTGTA*PTQAPGALAPPAAAWGSPLGSPMLTPSA
GLSKRAASATCGHAMWTSIHSLRQGRSVWLCTS
QRHP*TSHLRAASAHAPINPSTVEFAWTIGAAS
PTSLRLSTCPSSVLMGLASPARSYGLMPASVT*A
VGIPMTSLLTWNPTLTSQKLPTRQAQILGLGD*
PNACEAVSPYGQ*LFTNEP*LP*SGPLASISVS
NHSNDA*WCCSGPCYEFSP*YHSASTLKKNACL*
LFWTTPKPDPAFPSH*KSCWILPKSQEMESGRL
LISLISSLDAKPQDSLGPFR*IDGIWNNRIIYY
LEPAKRYCNG*F*RQRTKTILIPNMYAPQGHQTF
AK*VE*LLNFDF*WKVVSINLGIVEVKFLFTPT
L*RVQIRFVPVRNKI**TFLLMGKAPS*YSRDR
ERSARFRRTN*LSH*ISC*LAGLWAVGQALP*IF
SLVLLGVHRNW*GLWTGLSGP*EWCPGTLLYSY
RALRDPAADHARPTEMTKTGSGRGVGQTKKWVP
LVAAWGDL*SWRLWDSRGPRVQDTSIAETHFTAF
RSADQMASFLVGRWRFTGCLETEIDLIKV*S*R
G*S*KEKVVVNEYQAIIYCIRKI*YLLLEFFYL
GPFLCQTLLSVLCMY*LTESSRQC*EVPIIISVL
TNVKRKLIEVRKLNQSHPVGDWES*DSDRNWTV
FITHIFPLFLELPNVSE*ENIAINGLIF*CHFS
LL*SF*LLFKRREYLIF**FRCLSIQNTWDTQKS
RNPL*LIPSFPSEPALITHLKDDSVYPMLHIEC
CVVIHREFCAVCREIPKREKDWEYILLTVTSPK
PSPVQGIQWCSLNT**IQEAVHVFLLLFEALFFQ
SYMKIEF*QSKFYIKCLSKRDI*YFKEMHMYVY
IYLCMRMQEFLYKENSLHE*SLL*VSVNHVRFS
ESENTCHLQITRLDNSSLHLKFSGNPRARFLLNL
HLNLGN*T*LSKIIGSLVGETRDYSGNGCRKVV
RITQSPLVLRNGTILCRARRASLRPMG*SHGEG
NLDPM**SAF*VRISLQWCGLIQ*KLRIINIMEK
NLH*LSVYLVPSTMLSCSLFYLIVTAILSMHLS
LFYKWKREVPPKS*SSNSSLFYQPLLLRRPLEK
T*MTPIGELHLQGASNRPNRSSPLWSLVNYMF*D
KGKLP*GLVNLC*GNLHSYLE*ITQVCLGVQKG
RRPEFTKLNLAKPYHKHFLSA*HTPSLVEGAFL
PYLI*SSQQTYRIWHYHLSLTEV*SCTQGLTS**
TADQDWKPRIV*YLSHLFLCYA*LFCPPNQKA*
PL*EALY*Q*LQF*L*K*FRIIKDSRFE*HDCL
*SR*PCTVCA*QLQGSNLAPDYYVELCRCFLQTC
LDPKQSQ**PCISGNHKSTMYPCVCIYMYVCIY
FQTVI*YLNIPTAIFVTEKLHMRKRLRIFQ*RK
NNTWAICHVSQQFSFFS*FV*RGMCLLNVKGFHC
SISLCKSFP*GNKPSAKSHTGVGGFSCTGSCYE
TMMEH*ACSINVQMVE
Frame 2
IWCS*WAGQSGPSSPERWSDPLGCSVDACATDVQA*GGSCPGRWQQ*QQQPPAPSWPRCCG*GGGM
AQELHSLHKPLEPLLHQLRPGGLHSDLQC*RPV
LA*AREPPLQLAAMRCGHPYTH*GREEVSGCVPA
RGIHELHTCGLHQHTLLSTQVLWSLHGQ*VLHP
LQV*DYRRVLPVS*WAWLLPPGPMD*CLLL*PE
L*ESQ*HLC*LGILP*LLRNCQLGRHKSWVLGTN
PMPVKQSALMANNFSPMSLSYPDLDPWPPFLSL
TIQMTPDGAAQAHAMSFLLDIIQHLL*RKMPVS
SCSGLHPSLIQPFQVTRSPAGSCLNPKKWNQVDF
*YH*FLL*MPNHKTLWVHSDE*MEFGTIE*SII
WSLPRGTVMGNSDVSAPKLS*FQICMHLKVIKH
LPSELNSCLILIFNGKLYPLTWALLRLSFSSPLH
CEGYRLGLSQSEIKFDKHSC*WEKPPVNTPETG
KGQPVSEGPIDSHTESAADWQGFGQLARLFLES
SPLSCLGFIGIGKASGLACLAPESGALEHSSTLT
EP*ETQLQTMPDPLK*PRQVQVGVWVKPRSGCP
W*QPGVTSRAGGCGTPGAPVFRTHLLQRLISQP
FVLLTKWPVFW*EDGGLPVV*KQK*T**RFKAEE
VEAKRKRLLLMNIRLLFIVLGKYNIYC*NSFI*
GLFCARHCSQCFACISSLNLHDNVEKFPLLFLF
LQM*NGSS*R*ENSTRVTQLVTGKVRIQIEIGLS
L*PIFSPCF*SFQMCQNRKTLQ*MA*FFNVIFP
SYSLSSSFSKDENI*FSDNLGA*ASKIHGTHKN
PGIPCSLFPLSHRNQLSSHI*KMILFTQCCILNV
V*LFTGNSVQCAERFLNGKRTGNTSSLL*PPQN
LVQCKVYSGAH*ILDEYRKLCMCSYFYSKLSSS
KAT*K*NFNSQNFILSALAKETFNISKKCICMYT
YICVCVCKNSCIKRIHSMNDLFCKSV*IMLDFL
RVKTPAIYKLQGWITAHSI*NSVETQELGSY*I
CISIWETELSFQRS*EVWLEKLGIILAMGAGRWS
E*PSRHWF*ETELSYAEPGGQVSDPWVEAMEKE
IWIQCNEALSKSEFPCNGVA*FNKN*E**I*WK
KISTD*VFTWCQALC*VVHYFI*LLQQF*VCIFH
YFISGKEKCPQKVRAQTAAYSTSPCSCGGLWKR
PE*HLLENYIYKGLQTDQIDHHLCGPLLTICSE
TKESYPKG*LTFAEEIYIHT*SELLRCA*VCKRE
GDLNSPS*ILLNLIISIF*ALSIHQALWKVLSC
HISFNPHSKPIEYGIII*VSQKFSRVLKVLPAS
EQQTKTGNPG*SDT*AISSCATPSYSVPQIKRHD
LYKRRFTDNSCNFNFENDSELSKIVDSNDMIVY
NLASLVLCVHSNYREVI*LLTIMLNYVAAFYKL
VLIQSSHNDNPAYLGIISQLCIPVCVYICMYVSI
FKL*FNI*IFLLPFL*LKNYT*GNVLEFSNRGK
ITLGQSVMFHNSSHFSHDLCSVECVCSM*RVFI
AQFLCVSLFLKVINHQQSHILELVAFLVQAVVMR
Q*WSIEHVQ*MCRWWK
Sequence WISP1.aAug05
ATATCTGGTGCTCCTGATGGGCCGGCCAGTCTGGGCCCAGCTCCCCCGAGAGGTGGTCGGATCCTCTGGGCTGCTCGGTCGATGCCTGTGCCACTGACGTCCAGGCATGAGGTGGTTCCTGCCCTGGACGCTGGCAGCAGTGACAGCAGCAGCCGCCAGCACCGTCCTGGCCACGGCCCTCTCTCCAGCCCCTACGACCA
TGGACTTTACCCCAGCTCCACTGGAGGACACCTCCTCACGCCCCCAATTCTGCAAGTGGCCATGTGAGTGCCCGCCATCCCCACCCCGCTGCCCGCTGGG
GGTCAGCCTCATCACAGATGGCTGTGAGTGCTGTAAGATGTGCGCTCAGCAGCTTGGGGACAACTGCACGGAGGCTGCCATCTGTGACCCCCACCGGGGC
CTCTACTGTGACTACAGCGGGGACCGCCCGAGGTACGCAATAGGAGTGTGTGCACAGGTGGTCGGTGTGGGCTGCGTCCTGGATGGGGTGCGCTACAACA
ACGGCCAGTCCTTCCAGCCTAACTGCAAGTACAACTGCACGTGCATCGACGGCGCGGTGGGCTGCACACCACTGTGCCTCCGAGTGCGCCCCCCGCGTCT
CTGGTGCCCCCACCCGCGGCGCGTGAGCATACCTGGCCACTGCTGTGAGCAGTGGGTATGTGAGGACGACGCCAAGAGGCCACGCAAGACCGCACCCCGT
GACACAGGAGCCTTCGATGCTGTGGGTGAGGTGGAGGCATGGCACAGGAACTGCATAGCCTACACAAGCCCCTGGAGCCCTTGCTCCACCAGCTGCGGCC
TGGGGGTCTCCACTCGGATCTCCAATGTTAACGCCCAGTGCTGGCCTGAGCAAGAGAGCCGCCTCTGCAACTTGCGGCCATGCGATGTGGACATCCATAC
ACTCATTAAGGCAGGGAAGAAGTGTCTGGCTGTGTACCAGCCAGAGGCATCCATGAACTTCACACTTGCGGGCTGCATCAGCACACGCTCCTATCAACCC
AAGTACTGTGGAGTTTGCATGGACAATAGGTGCTGCATCCCCTACAAGTCTAAGACTATCGACGTGTCCTTCCAGTGTCCTGATGGGCTTGGCTTCTCCC
GCCAGGTCCTATGGATTAATGCCTGCTTCTGTAACCTGAGCTGTAGGAATCCCAATGACATCTTTGCTGACTTGGAATCCTACCCTGACTTCTCAGAAAT
TGCCAACTAGGCAGGCACAAATCTTGGGTCTTGGGGACTAACCCAATGCCTGTGAAGCAGTCAGCCCTTATGGCCAATAACTTTTCACCAATGAGCCTTA
GTTACCCTGATCTGGACCCTTGGCCTCCATTTCTGTCTCTAACCATTCAAATGACGCCTGATGGTGCTGCTCAGGCCCATGCTATGAGTTTTCTCCTTGA
TATCATTCAGCATCTACTCTAAAGAAAAATGCCTGTCTCTAGCTGTTCTGGACTACACCCAAGCCTGATCCAGCCTTTCCAAGTCACTAGAAGTCCTGCT
GGATCTTGCCTAAATCCCAAGAAATGGAATCAGGTAGACTTTTAATATCACTAATTTCTTCTTTAGATGCCAAACCACAAGACTCTTTGGGTCCATTCAG
ATGAATAGATGGAATTTGGAACAATAGAATAATCTATTATTTGGAGCCTGCCAAGAGGTACTGTAATGGGTAATTCTGACGTCAGCGCACCAAAACTATC
CTGATTCCAAATATGTATGCACCTCAAGGTCATCAAACATTTGCCAAGTGAGTTGAATAGTTGCTTAATTTTGATTTTTAATGGAAAGTTGTATCCATTA
ACCTGGGCATTGTTGAGGTTAAGTTTCTCTTCACCCCTACACTGTGAAGGGTACAGATTAGGTTTGTCCCAGTCAGAAATAAAATTTGATAAACATTCCT
GTTGATGGGAAAAGCCCCCAGTTAATACTCCAGAGACAGGGAAAGGTCAGCCCGTTTCAGAAGGACCAATTGACTCTCACACTGAATCAGCTGCTGACTG
GCAGGGCTTTGGGCAGTTGGCCAGGCTCTTCCTTGAATCTTCTCCCTTGTCCTGCTTGGGGTTCATAGGAATTGGTAAGGCCTCTGGACTGGCCTGTCTG
GCCCCTGAGAGTGGTGCCCTGGAACACTCCTCTACTCTTACAGAGCCTTGAGAGACCCAGCTGCAGACCATGCCAGACCCACTGAAATGACCAAGACAGG
TTCAGGTAGGGGTGTGGGTCAAACCAAGAAGTGGGTGCCCTTGGTAGCAGCCTGGGGTGACCTCTAGAGCTGGAGGCTGTGGGACTCCAGGGGCCCCCGT
GTTCAGGACACATCTATTGCAGAGACTCATTTCACAGCCTTTCGTTCTGCTGACCAAATGGCCAGTTTTCTGGTAGGAAGATGGAGGTTTACCGGTTGTT
TAGAAACAGAAATAGACTTAATAAAGGTTTAAAGCTGAAGAGGTTGAAGCTAAAAGGAAAAGGTTGTTGTTAATGAATATCAGGCTATTATTTATTGTAT
TAGGAAAATATAATATTTACTGTTAGAATTCTTTTATTTAGGGCCTTTTCTGTGCCAGACATTGCTCTCAGTGCTTTGCATGTATTAGCTCACTGAATCT
TCACGACAATGTTGAGAAGTTCCCATTATTATTTCTGTTCTTACAAATGTGAAACGGAAGCTCATAGAGGTGAGAAAACTCAACCAGAGTCACCCAGTTG
GTGACTGGGAAAGTTAGGATTCAGATCGAAATTGGACTGTCTTTATAACCCATATTTTCCCCCTGTTTTTAGAGCTTCCAAATGTGTCAGAATAGGAAAA
CATTGCAATAAATGGCTTGATTTTTTAATGTCATTTTTCCCTCTTATAGTCTTTCTAGCTCCTTTTCAAAAGACGAGAATATCTGATTTTCTGATAATTT
AGGTGCTTAAGCATCCAAAATACATGGGACACACAAAAATCCAGGAATCCCCTGTAGCTTATTCCCTCTTTCCCATCGGAACCAGCTCTCATCACACATT
TAAAAGATGATTCTGTTTACCCAATGCTGCATATTGAATGTTGTGTAGTTATTCACAGGGAATTCTGTGCAGTGTGCAGAGAGATTCCTAAACGGGAAAA
GGACTGGGAATACATCCTCCTTACTGTGACCTCCCCAAAACCTAGTCCAGTGCAAGGTATACAGTGGTGCTCATTAAATACTTGATGAATACAGGAAGCT
GTGCATGTGTTCCTACTTTTATTCGAAGCTCTCTTCTTCCAAAGCTACATGAAAATAGAATTTTAACAGTCAAAATTTTATATTAAGTGCCTTAGCAAAA
GAGACATTTAATATTTCAAAGAAATGCATATGTATGTATACATATATTTGTGTATGCGTATGCAAGAATTCTTGTATAAAGAGAATTCACTCCATGAATG
ATCTCTTCTGTAAGTCAGTGTGAATCATGTTAGATTTTCTGAGAGTGAAAACACCTGCCATCTACAAATTACAAGGCTGGATAACAGCTCACTCCATTTG
AAATTCAGTGGAAACCCAAGAGCTAGGTTCTTACTGAATTTGCATCTCAATTTGGGAAACTGAACTTAGCTTTCAAAGATCATAGGAAGTCTGGTTGGAG
AAACTAGGGATTATTCTGGCAATGGGTGCAGGAAGGTGGTCAGAATAACCCAGTCGCCATTGGTTTTGAGAAACGGAACTATCTTATGCAGAGCCCGGAG
GGCAAGTCTCAGACCCATGGGTTGAAGCCATGGAGAAGGAAATTTGGATCCAATGTAATGAAGCGCTTTCTAAGTCAGAATTTCCCTGCAATGGTGTGGC
CTGATTCAATAAAAATTAAGAATAATAAATATAATGGAAAAAAATCTCCACTGATTGAGTGTTTACTTGGTGCCAAGCACTATGCTAAGTTGTTCATTAT
TTTATTTAATTGTTACAGCAATTTTGAGTATGCATCTTTCACTATTTTATAAGTGGAAAAGAGAAGTGCCCCCAAAAAGTTAGAGCTCAAACAGCAGCTT
ATTCTACCAGCCCCTGCTCTTGCGGAGGCCTCTGGAAAAGACCTGAATGACACCTATTGGAGAATTACATCTACAAGGGGCTTCAAACAGACCAAATAGA
TCATCACCTCTGTGGTCCCTTGTTAACTATATGTTCTGAGACAAAGGAAAGCTACCCTAAGGGTTAGTTAACCTTTGCTGAGGAAATTTACATTCATACT
TAGAGTGAATTACTCAGGTGTGCTTAGGTGTGCAAAAGGGAAGGAGACCTGAATTCACCAAGTTAAATCTTGCTAAACCTTATCATAAGCATTTTTTGAG
CGCTTAGCATACACCAAGCCTTGTGGAAGGTGCTTTCCTGCCATATCTCATTTAATCCTCACAGCAAACCTATAGAATATGGCATTATCATCTGAGTCTC
ACAGAAGTTTAGTCGTGTACTCAAGGTCTTACCAGCTAGTGAACAGCAGACCAAGACTGGAAACCCAGGATAGTCTGATACCTGAGCCATCTCTTCTTGT
GCTACGCCTAGTTATTCTGTCCCCCAAATCAAAAGGCATGACCTTTATAAGAGGCGCTTTACTGACAATAGCTGCAATTTTAACTTTGAAAATGATTCAG
AATTATCAAAGATAGTAGATTCGAATGACATGATTGTCTATAATCTCGCTAGCCTTGTACTGTGTGTGCATAGCAATTACAGGGAAGTAATCTAGCTCCT
GACTATTATGTTGAACTATGTCGCTGCTTTTTACAAACTTGTCTTGATCCAAAGCAGTCACAATGATAACCCTGCATATCTGGGAATCATAAGTCAACTA
TGTATCCCTGTGTGTGTATATATATGTATGTATGTATCTATTTTCAAACTGTGATTTAATATTTAAATATTCCTACTGCCATTTTTGTGACTGAAAAACT
ACACATGAGGAAACGTCTTAGAATTTTCCAATAGAGGAAAAATAACACTTGGGCAATCTGTCATGTTTCACAACAGTTCTCATTTTTCTCATGATTTGTG
TAGCGTGGAATGTGTTTGCTCAATGTGAAGGGTTTTCATTGCTCAATTTCTCTGTGTAAGTCTTTTCCTTAAGGTAATAAACCATCAGCAAAGTCACATA
CTGGAGTTGGTGGCTTTTCTTGTACAGGCAGTTGTTATGAGACAATGATGGAGCATTGAGCATGTTCAATAAATGTGCAGATGGTGGAAA
- WISP1.u.f.1 (forward primer)
- WISP1.u.r.4 (reverse primer)
- Multiple exon skipping
Frame 0
ISGAPDGPASLGPAPPRGGRILWAARSMPVPLTSRHEVVPALDAGSSDSSSRQHRPGHGPLSSPYDH
GLYPSSTGGHLLTPPILQVAM*VPAIPTPLPAG
GQPHHRWL*VL*DVRSAAWGQLHGGCHL*PPPG
PLL*LQRGPPEVRNRSVCTGGRCGLRPGWGALQQ
RPVLPA*LQVQLHVHRRRGGLHTTVPPSAPPAS
LVPPPAAREHTWPLL*AVGM*GRRQEATQDRTP
*HRSLRCCG*GGGMAQELHSLHKPLEPLLHQLRP
GGLHSDLQC*RPVLA*AREPPLQLAAMRCGHPY
TH*GREEVSGCVPARGIHELHTCGLHQHTLLST
QVLWSLHGQ*VLHPLQV*DYRRVLPVS*WAWLLP
PGPMD*CLLL*PEL*ESQ*HLC*LGILP*LLRN
CQLGRHKSWVLGTNPMPVKQSALMANNFSPMSL
SYPDLDPWPPFLSLTIQMTPDGAAQAHAMSFLLD
IIQHLL*RKMPVSSCSGLHPSLIQPFQVTRSPA
GSCLNPKKWNQVDF*YH*FLL*MPNHKTLWVHS
DE*MEFGTIE*SIIWSLPRGTVMGNSDVSAPKLS
*FQICMHLKVIKHLPSELNSCLILIFNGKLYPL
TWALLRLSFSSPLHCEGYRLGLSQSEIKFDKHS
C*WEKPPVNTPETGKGQPVSEGPIDSHTESAADW
QGFGQLARLFLESSPLSCLGFIGIGKASGLACL
APESGALEHSSTLTEP*ETQLQTMPDPLK*PRQ
VQVGVWVKPRSGCPW*QPGVTSRAGGCGTPGAPV
FRTHLLQRLISQPFVLLTKWPVFW*EDGGLPVV
*KQK*T**RFKAEEVEAKRKRLLLMNIRLLFIV
LGKYNIYC*NSFI*GLFCARHCSQCFACISSLNL
HDNVEKFPLLFLFLQM*NGSS*R*ENSTRVTQL
VTGKVRIQIEIGLSL*PIFSPCF*SFQMCQNRK
TLQ*MA*FFNVIFPSYSLSSSFSKDENI*FSDNL
GA*ASKIHGTHKNPGIPCSLFPLSHRNQLSSHI
*KMILFTQCCILNVV*LFTGNSVQCAERFLNGK
RTGNTSSLL*PPQNLVQCKVYSGAH*ILDEYRKL
CMCSYFYSKLSSSKAT*K*NFNSQNFILSALAK
ETFNISKKCICMYTYICVCVCKNSCIKRIHSMN
DLFCKSV*IMLDFLRVKTPAIYKLQGWITAHSI*
NSVETQELGSY*ICISIWETELSFQRS*EVWLE
KLGIILAMGAGRWSE*PSRHWF*ETELSYAEPG
GQVSDPWVEAMEKEIWIQCNEALSKSEFPCNGVA
*FNKN*E**I*WKKISTD*VFTWCQALC*VVHY
FI*LLQQF*VCIFHYFISGKEKCPQKVRAQTAA
YSTSPCSCGGLWKRPE*HLLENYIYKGLQTDQID
HHLCGPLLTICSETKESYPKG*LTFAEEIYIHT
*SELLRCA*VCKREGDLNSPS*ILLNLIISIF*
ALSIHQALWKVLSCHISFNPHSKPIEYGIII*VS
QKFSRVLKVLPASEQQTKTGNPG*SDT*AISSC
ATPSYSVPQIKRHDLYKRRFTDNSCNFNFENDS
ELSKIVDSNDMIVYNLASLVLCVHSNYREVI*LL
TIMLNYVAAFYKLVLIQSSHNDNPAYLGIISQL
CIPVCVYICMYVSIFKL*FNI*IFLLPFL*LKN
YT*GNVLEFSNRGKITLGQSVMFHNSSHFSHDLC
SVECVCSM*RVFIAQFLCVSLFLKVINHQQSHI
LELVAFLVQAVVMRQ*WSIEHVQ*MCRWWK
Frame 1
YLVLLMGRPVWAQLPREVVGSSGLLGRCLCH*RPGMRWFLPWTLAAVTAAAASTVLATALSPAPTT
MDFTPAPLEDTSSRPQFCKWPCECPPSPPRCPLG
VSLITDGCECCKMCAQQLGDNCTEAAICDPHRG
LYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYN
NGQSFQPNCKYNCTCIDGAVGCTPLCLRVRPPRL
WCPHPRRVSIPGHCCEQWVCEDDAKRPRKTAPR
DTGAFDAVGEVEAWHRNCIAYTSPWSPCSTSCG
LGVSTRISNVNAQCWPEQESRLCNLRPCDVDIHT
LIKAGKKCLAVYQPEASMNFTLAGCISTRSYQP
KYCGVCMDNRCCIPYKSKTIDVSFQCPDGLGFS
RQVLWINACFCNLSCRNPNDIFADLESYPDFSEI
AN*AGTNLGSWGLTQCL*SSQPLWPITFHQ*AL
VTLIWTLGLHFCL*PFK*RLMVLLRPML*VFSL
ISFSIYSKEKCLSLAVLDYTQA*SSLSKSLEVLL
DLA*IPRNGIR*TFNITNFFFRCQTTRLFGSIQ
MNRWNLEQ*NNLLFGACQEVL*WVILTSAHQNY
PDSKYVCTSRSSNICQVS*IVA*F*FLMESCIH*
PGHC*G*VSLHPYTVKGTD*VCPSQK*NLINIP
VDGKSPQLILQRQGKVSPFQKDQLTLTLNQLLT
GRALGSWPGSSLNLLPCPAWGS*ELVRPLDWPVW
PLRVVPWNTPLLLQSLERPSCRPCQTH*NDQDR
FR*GCGSNQEVGALGSSLG*PLELEAVGLQGPP
CSGHIYCRDSFHSLSFC*PNGQFSGRKMEVYRLF
RNRNRLNKGLKLKRLKLKGKGCC**ISGYYLLY
*ENIIFTVRILLFRAFSVPDIALSALHVLAH*I
FTTMLRSSHYYFCSYKCETEAHRGEKTQPESPSW
*LGKLGFRSKLDCLYNPYFPPVFRASKCVRIGK
HCNKWLDFLMSFFPLIVFLAPFQKTRISDFLII
*VLKHPKYMGHTKIQESPVAYSLFPIGTSSHHTF
KR*FCLPNAAY*MLCSYSQGILCSVQRDS*TGK
GLGIHPPYCDLPKT*SSARYTVVLIKYLMNTGS
CACVPTFIRSSLLPKLHENRILTVKILY*VP*QK
RHLIFQRNAYVCIHIFVYAYARILV*REFTP*M
ISSVSQCESC*IF*E*KHLPSTNYKAG*QLTPF
EIQWKPKS*VLTEFASQFGKLNLAFKDHRKSGWR
N*GLFWQWVQEGGQNNPVAIGFEKRNYLMQSPE
GKSQTHGLKPWRRKFGSNVMKRFLSQNFPAMVW
PDSIKIKNNKYNGKKSPLIECLLGAKHYAKLFII
LFNCYSNFEYASFTIL*VEKRSAPKKLELKQQL
ILPAPALAEASGKDLNDTYWRITSTRGFKQTK*
IITSVVPC*LYVLRQRKATLRVS*PLLRKFTFIL
RVNYSGVLRCAKGKET*IHQVKSC*TLS*AFFE
RLAYTKPCGRCFPAISHLILTANL*NMALSSES
HRSLVVYSRSYQLVNSRPRLETQDSLIPEPSLLV
LRLVILSPKSKGMTFIRGALLTIAAILTLKMIQ
NYQR**IRMT*LSIISLALYCVCIAITGK*SSS
*LLC*TMSLLFTNLS*SKAVTMITLHIWES*VNY
VSLCVYIYVCMYLFSNCDLIFKYSYCHFCD*KT
THEETS*NFPIEEK*HLGNLSCFTTVLIFLMIC
VAWNVFAQCEGFSLLNFSV*VFSLR**TISKVTY
WSWWLFLYRQLL*DNDGALSMFNKCADGG
Frame 2
IWCS*WAGQSGPSSPERWSDPLGCSVDACATDVQA*GGSCPGRWQQ*QQQPPAPSWPRPSLQPLRP
WTLPQLHWRTPPHAPNSASGHVSARHPHPAARW
GSASSQMAVSAVRCALSSLGTTARRLPSVTPTGA
STVTTAGTARGTQ*ECVHRWSVWAASWMGCATT
TASPSSLTASTTARASTARWAAHHCASECAPRV
SGAPTRGA*AYLATAVSSGYVRTTPRGHARPHPV
TQEPSMLWVRWRHGTGTA*PTQAPGALAPPAAA
WGSPLGSPMLTPSAGLSKRAASATCGHAMWTSI
HSLRQGRSVWLCTSQRHP*TSHLRAASAHAPINP
STVEFAWTIGAASPTSLRLSTCPSSVLMGLASP
ARSYGLMPASVT*AVGIPMTSLLTWNPTLTSQK
LPTRQAQILGLGD*PNACEAVSPYGQ*LFTNEP*
LP*SGPLASISVSNHSNDA*WCCSGPCYEFSP*
YHSASTLKKNACL*LFWTTPKPDPAFPSH*KSC
WILPKSQEMESGRLLISLISSLDAKPQDSLGPFR
*IDGIWNNRIIYYLEPAKRYCNG*F*RQRTKTI
LIPNMYAPQGHQTFAK*VE*LLNFDF*WKVVSI
NLGIVEVKFLFTPTL*RVQIRFVPVRNKI**TFL
LMGKAPS*YSRDRERSARFRRTN*LSH*ISC*L
AGLWAVGQALP*IFSLVLLGVHRNW*GLWTGLS
GP*EWCPGTLLYSYRALRDPAADHARPTEMTKTG
SGRGVGQTKKWVPLVAAWGDL*SWRLWDSRGPR
VQDTSIAETHFTAFRSADQMASFLVGRWRFTGC
LETEIDLIKV*S*RG*S*KEKVVVNEYQAIIYCI
RKI*YLLLEFFYLGPFLCQTLLSVLCMY*LTES
SRQC*EVPIIISVLTNVKRKLIEVRKLNQSHPV
GDWES*DSDRNWTVFITHIFPLFLELPNVSE*EN
IAINGLIF*CHFSLL*SF*LLFKRREYLIF**F
RCLSIQNTWDTQKSRNPL*LIPSFPSEPALITH
LKDDSVYPMLHIECCVVIHREFCAVCREIPKREK
DWEYILLTVTSPKPSPVQGIQWCSLNT**IQEA
VHVFLLLFEALFFQSYMKIEF*QSKFYIKCLSK
RDI*YFKEMHMYVYIYLCMRMQEFLYKENSLHE*
SLL*VSVNHVRFSESENTCHLQITRLDNSSLHL
KFSGNPRARFLLNLHLNLGN*T*LSKIIGSLVG
ETRDYSGNGCRKVVRITQSPLVLRNGTILCRARR
ASLRPMG*SHGEGNLDPM**SAF*VRISLQWCG
LIQ*KLRIINIMEKNLH*LSVYLVPSTMLSCSL
FYLIVTAILSMHLSLFYKWKREVPPKS*SSNSSL
FYQPLLLRRPLEKT*MTPIGELHLQGASNRPNR
SSPLWSLVNYMF*DKGKLP*GLVNLC*GNLHSY
LE*ITQVCLGVQKGRRPEFTKLNLAKPYHKHFLS
A*HTPSLVEGAFLPYLI*SSQQTYRIWHYHLSL
TEV*SCTQGLTS**TADQDWKPRIV*YLSHLFL
CYA*LFCPPNQKA*PL*EALY*Q*LQF*L*K*FR
IIKDSRFE*HDCL*SR*PCTVCA*QLQGSNLAP
DYYVELCRCFLQTCLDPKQSQ**PCISGNHKST
MYPCVCIYMYVCIYFQTVI*YLNIPTAIFVTEKL
HMRKRLRIFQ*RKNNTWAICHVSQQFSFFS*FV
*RGMCLLNVKGFHCSISLCKSFP*GNKPSAKSH
TGVGGFSCTGSCYETMMEH*ACSINVQMVE
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