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Sequence WISP1.eAug05
ATATCTGGTGCTCCTGATGGGCCGGCCAGTCTGGGCCCAGCTCCCCCGAGAGGTGGTCGGATCCTCTGGGCTGCTCGGTCGATGCCTGTGCCACTGACGTCCAGGCATGAGGTGGTTCCTGCCCTGGACGCTGGCAGCAGTGACAGCAGCAGCCGCCAGCACCGTCCTGGCCACGGCAGGGAAGAAGTGTCTGGCTGTGT
ACCAGCCAGAGGCATCCATGAACTTCACACTTGCGGGCTGCATCAGCACACGCTCCTATCAACCCAAGTACTGTGGAGTTTGCATGGACAATAGGTGCTG
CATCCCCTACAAGTCTAAGACTATCGACGTGTCCTTCCAGTGTCCTGATGGGCTTGGCTTCTCCCGCCAGGTCCTATGGATTAATGCCTGCTTCTGTAAC
CTGAGCTGTAGGAATCCCAATGACATCTTTGCTGACTTGGAATCCTACCCTGACTTCTCAGAAATTGCCAACTAGGCAGGCACAAATCTTGGGTCTTGGG
GACTAACCCAATGCCTGTGAAGCAGTCAGCCCTTATGGCCAATAACTTTTCACCAATGAGCCTTAGTTACCCTGATCTGGACCCTTGGCCTCCATTTCTG
TCTCTAACCATTCAAATGACGCCTGATGGTGCTGCTCAGGCCCATGCTATGAGTTTTCTCCTTGATATCATTCAGCATCTACTCTAAAGAAAAATGCCTG
TCTCTAGCTGTTCTGGACTACACCCAAGCCTGATCCAGCCTTTCCAAGTCACTAGAAGTCCTGCTGGATCTTGCCTAAATCCCAAGAAATGGAATCAGGT
AGACTTTTAATATCACTAATTTCTTCTTTAGATGCCAAACCACAAGACTCTTTGGGTCCATTCAGATGAATAGATGGAATTTGGAACAATAGAATAATCT
ATTATTTGGAGCCTGCCAAGAGGTACTGTAATGGGTAATTCTGACGTCAGCGCACCAAAACTATCCTGATTCCAAATATGTATGCACCTCAAGGTCATCA
AACATTTGCCAAGTGAGTTGAATAGTTGCTTAATTTTGATTTTTAATGGAAAGTTGTATCCATTAACCTGGGCATTGTTGAGGTTAAGTTTCTCTTCACC
CCTACACTGTGAAGGGTACAGATTAGGTTTGTCCCAGTCAGAAATAAAATTTGATAAACATTCCTGTTGATGGGAAAAGCCCCCAGTTAATACTCCAGAG
ACAGGGAAAGGTCAGCCCGTTTCAGAAGGACCAATTGACTCTCACACTGAATCAGCTGCTGACTGGCAGGGCTTTGGGCAGTTGGCCAGGCTCTTCCTTG
AATCTTCTCCCTTGTCCTGCTTGGGGTTCATAGGAATTGGTAAGGCCTCTGGACTGGCCTGTCTGGCCCCTGAGAGTGGTGCCCTGGAACACTCCTCTAC
TCTTACAGAGCCTTGAGAGACCCAGCTGCAGACCATGCCAGACCCACTGAAATGACCAAGACAGGTTCAGGTAGGGGTGTGGGTCAAACCAAGAAGTGGG
TGCCCTTGGTAGCAGCCTGGGGTGACCTCTAGAGCTGGAGGCTGTGGGACTCCAGGGGCCCCCGTGTTCAGGACACATCTATTGCAGAGACTCATTTCAC
AGCCTTTCGTTCTGCTGACCAAATGGCCAGTTTTCTGGTAGGAAGATGGAGGTTTACCGGTTGTTTAGAAACAGAAATAGACTTAATAAAGGTTTAAAGC
TGAAGAGGTTGAAGCTAAAAGGAAAAGGTTGTTGTTAATGAATATCAGGCTATTATTTATTGTATTAGGAAAATATAATATTTACTGTTAGAATTCTTTT
ATTTAGGGCCTTTTCTGTGCCAGACATTGCTCTCAGTGCTTTGCATGTATTAGCTCACTGAATCTTCACGACAATGTTGAGAAGTTCCCATTATTATTTC
TGTTCTTACAAATGTGAAACGGAAGCTCATAGAGGTGAGAAAACTCAACCAGAGTCACCCAGTTGGTGACTGGGAAAGTTAGGATTCAGATCGAAATTGG
ACTGTCTTTATAACCCATATTTTCCCCCTGTTTTTAGAGCTTCCAAATGTGTCAGAATAGGAAAACATTGCAATAAATGGCTTGATTTTTTAATGTCATT
TTTCCCTCTTATAGTCTTTCTAGCTCCTTTTCAAAAGACGAGAATATCTGATTTTCTGATAATTTAGGTGCTTAAGCATCCAAAATACATGGGACACACA
AAAATCCAGGAATCCCCTGTAGCTTATTCCCTCTTTCCCATCGGAACCAGCTCTCATCACACATTTAAAAGATGATTCTGTTTACCCAATGCTGCATATT
GAATGTTGTGTAGTTATTCACAGGGAATTCTGTGCAGTGTGCAGAGAGATTCCTAAACGGGAAAAGGACTGGGAATACATCCTCCTTACTGTGACCTCCC
CAAAACCTAGTCCAGTGCAAGGTATACAGTGGTGCTCATTAAATACTTGATGAATACAGGAAGCTGTGCATGTGTTCCTACTTTTATTCGAAGCTCTCTT
CTTCCAAAGCTACATGAAAATAGAATTTTAACAGTCAAAATTTTATATTAAGTGCCTTAGCAAAAGAGACATTTAATATTTCAAAGAAATGCATATGTAT
GTATACATATATTTGTGTATGCGTATGCAAGAATTCTTGTATAAAGAGAATTCACTCCATGAATGATCTCTTCTGTAAGTCAGTGTGAATCATGTTAGAT
TTTCTGAGAGTGAAAACACCTGCCATCTACAAATTACAAGGCTGGATAACAGCTCACTCCATTTGAAATTCAGTGGAAACCCAAGAGCTAGGTTCTTACT
GAATTTGCATCTCAATTTGGGAAACTGAACTTAGCTTTCAAAGATCATAGGAAGTCTGGTTGGAGAAACTAGGGATTATTCTGGCAATGGGTGCAGGAAG
GTGGTCAGAATAACCCAGTCGCCATTGGTTTTGAGAAACGGAACTATCTTATGCAGAGCCCGGAGGGCAAGTCTCAGACCCATGGGTTGAAGCCATGGAG
AAGGAAATTTGGATCCAATGTAATGAAGCGCTTTCTAAGTCAGAATTTCCCTGCAATGGTGTGGCCTGATTCAATAAAAATTAAGAATAATAAATATAAT
GGAAAAAAATCTCCACTGATTGAGTGTTTACTTGGTGCCAAGCACTATGCTAAGTTGTTCATTATTTTATTTAATTGTTACAGCAATTTTGAGTATGCAT
CTTTCACTATTTTATAAGTGGAAAAGAGAAGTGCCCCCAAAAAGTTAGAGCTCAAACAGCAGCTTATTCTACCAGCCCCTGCTCTTGCGGAGGCCTCTGG
AAAAGACCTGAATGACACCTATTGGAGAATTACATCTACAAGGGGCTTCAAACAGACCAAATAGATCATCACCTCTGTGGTCCCTTGTTAACTATATGTT
CTGAGACAAAGGAAAGCTACCCTAAGGGTTAGTTAACCTTTGCTGAGGAAATTTACATTCATACTTAGAGTGAATTACTCAGGTGTGCTTAGGTGTGCAA
AAGGGAAGGAGACCTGAATTCACCAAGTTAAATCTTGCTAAACCTTATCATAAGCATTTTTTGAGCGCTTAGCATACACCAAGCCTTGTGGAAGGTGCTT
TCCTGCCATATCTCATTTAATCCTCACAGCAAACCTATAGAATATGGCATTATCATCTGAGTCTCACAGAAGTTTAGTCGTGTACTCAAGGTCTTACCAG
CTAGTGAACAGCAGACCAAGACTGGAAACCCAGGATAGTCTGATACCTGAGCCATCTCTTCTTGTGCTACGCCTAGTTATTCTGTCCCCCAAATCAAAAG
GCATGACCTTTATAAGAGGCGCTTTACTGACAATAGCTGCAATTTTAACTTTGAAAATGATTCAGAATTATCAAAGATAGTAGATTCGAATGACATGATT
GTCTATAATCTCGCTAGCCTTGTACTGTGTGTGCATAGCAATTACAGGGAAGTAATCTAGCTCCTGACTATTATGTTGAACTATGTCGCTGCTTTTTACA
AACTTGTCTTGATCCAAAGCAGTCACAATGATAACCCTGCATATCTGGGAATCATAAGTCAACTATGTATCCCTGTGTGTGTATATATATGTATGTATGT
ATCTATTTTCAAACTGTGATTTAATATTTAAATATTCCTACTGCCATTTTTGTGACTGAAAAACTACACATGAGGAAACGTCTTAGAATTTTCCAATAGA
GGAAAAATAACACTTGGGCAATCTGTCATGTTTCACAACAGTTCTCATTTTTCTCATGATTTGTGTAGCGTGGAATGTGTTTGCTCAATGTGAAGGGTTT
TCATTGCTCAATTTCTCTGTGTAAGTCTTTTCCTTAAGGTAATAAACCATCAGCAAAGTCACATACTGGAGTTGGTGGCTTTTCTTGTACAGGCAGTTGT
TATGAGACAATGATGGAGCATTGAGCATGTTCAATAAATGTGCAGATGGTGGAAA
- WISP1.u.f.1 (forward primer)
- WISP1.u.r.4 (reverse primer)
- Single exon skipping
Frame 0
ISGAPDGPASLGPAPPRGGRILWAARSMPVPLTSRHEVVPALDAGSSDSSSRQHRPGHGREEVSGCV
PARGIHELHTCGLHQHTLLSTQVLWSLHGQ*VL
HPLQV*DYRRVLPVS*WAWLLPPGPMD*CLLL*
PEL*ESQ*HLC*LGILP*LLRNCQLGRHKSWVLG
TNPMPVKQSALMANNFSPMSLSYPDLDPWPPFL
SLTIQMTPDGAAQAHAMSFLLDIIQHLL*RKMP
VSSCSGLHPSLIQPFQVTRSPAGSCLNPKKWNQV
DF*YH*FLL*MPNHKTLWVHSDE*MEFGTIE*S
IIWSLPRGTVMGNSDVSAPKLS*FQICMHLKVI
KHLPSELNSCLILIFNGKLYPLTWALLRLSFSSP
LHCEGYRLGLSQSEIKFDKHSC*WEKPPVNTPE
TGKGQPVSEGPIDSHTESAADWQGFGQLARLFL
ESSPLSCLGFIGIGKASGLACLAPESGALEHSST
LTEP*ETQLQTMPDPLK*PRQVQVGVWVKPRSG
CPW*QPGVTSRAGGCGTPGAPVFRTHLLQRLIS
QPFVLLTKWPVFW*EDGGLPVV*KQK*T**RFKA
EEVEAKRKRLLLMNIRLLFIVLGKYNIYC*NSF
I*GLFCARHCSQCFACISSLNLHDNVEKFPLLF
LFLQM*NGSS*R*ENSTRVTQLVTGKVRIQIEIG
LSL*PIFSPCF*SFQMCQNRKTLQ*MA*FFNVI
FPSYSLSSSFSKDENI*FSDNLGA*ASKIHGTH
KNPGIPCSLFPLSHRNQLSSHI*KMILFTQCCIL
NVV*LFTGNSVQCAERFLNGKRTGNTSSLL*PP
QNLVQCKVYSGAH*ILDEYRKLCMCSYFYSKLS
SSKAT*K*NFNSQNFILSALAKETFNISKKCICM
YTYICVCVCKNSCIKRIHSMNDLFCKSV*IMLD
FLRVKTPAIYKLQGWITAHSI*NSVETQELGSY
*ICISIWETELSFQRS*EVWLEKLGIILAMGAGR
WSE*PSRHWF*ETELSYAEPGGQVSDPWVEAME
KEIWIQCNEALSKSEFPCNGVA*FNKN*E**I*
WKKISTD*VFTWCQALC*VVHYFI*LLQQF*VCI
FHYFISGKEKCPQKVRAQTAAYSTSPCSCGGLW
KRPE*HLLENYIYKGLQTDQIDHHLCGPLLTIC
SETKESYPKG*LTFAEEIYIHT*SELLRCA*VCK
REGDLNSPS*ILLNLIISIF*ALSIHQALWKVL
SCHISFNPHSKPIEYGIII*VSQKFSRVLKVLP
ASEQQTKTGNPG*SDT*AISSCATPSYSVPQIKR
HDLYKRRFTDNSCNFNFENDSELSKIVDSNDMI
VYNLASLVLCVHSNYREVI*LLTIMLNYVAAFY
KLVLIQSSHNDNPAYLGIISQLCIPVCVYICMYV
SIFKL*FNI*IFLLPFL*LKNYT*GNVLEFSNR
GKITLGQSVMFHNSSHFSHDLCSVECVCSM*RV
FIAQFLCVSLFLKVINHQQSHILELVAFLVQAVV
MRQ*WSIEHVQ*MCRWWK
Frame 1
YLVLLMGRPVWAQLPREVVGSSGLLGRCLCH*RPGMRWFLPWTLAAVTAAAASTVLATAGKKCLAV
YQPEASMNFTLAGCISTRSYQPKYCGVCMDNRCC
IPYKSKTIDVSFQCPDGLGFSRQVLWINACFCN
LSCRNPNDIFADLESYPDFSEIAN*AGTNLGSW
GLTQCL*SSQPLWPITFHQ*ALVTLIWTLGLHFC
L*PFK*RLMVLLRPML*VFSLISFSIYSKEKCL
SLAVLDYTQA*SSLSKSLEVLLDLA*IPRNGIR
*TFNITNFFFRCQTTRLFGSIQMNRWNLEQ*NNL
LFGACQEVL*WVILTSAHQNYPDSKYVCTSRSS
NICQVS*IVA*F*FLMESCIH*PGHC*G*VSLH
PYTVKGTD*VCPSQK*NLINIPVDGKSPQLILQR
QGKVSPFQKDQLTLTLNQLLTGRALGSWPGSSL
NLLPCPAWGS*ELVRPLDWPVWPLRVVPWNTPL
LLQSLERPSCRPCQTH*NDQDRFR*GCGSNQEVG
ALGSSLG*PLELEAVGLQGPPCSGHIYCRDSFH
SLSFC*PNGQFSGRKMEVYRLFRNRNRLNKGLK
LKRLKLKGKGCC**ISGYYLLY*ENIIFTVRILL
FRAFSVPDIALSALHVLAH*IFTTMLRSSHYYF
CSYKCETEAHRGEKTQPESPSW*LGKLGFRSKL
DCLYNPYFPPVFRASKCVRIGKHCNKWLDFLMSF
FPLIVFLAPFQKTRISDFLII*VLKHPKYMGHT
KIQESPVAYSLFPIGTSSHHTFKR*FCLPNAAY
*MLCSYSQGILCSVQRDS*TGKGLGIHPPYCDLP
KT*SSARYTVVLIKYLMNTGSCACVPTFIRSSL
LPKLHENRILTVKILY*VP*QKRHLIFQRNAYV
CIHIFVYAYARILV*REFTP*MISSVSQCESC*I
F*E*KHLPSTNYKAG*QLTPFEIQWKPKS*VLT
EFASQFGKLNLAFKDHRKSGWRN*GLFWQWVQE
GGQNNPVAIGFEKRNYLMQSPEGKSQTHGLKPWR
RKFGSNVMKRFLSQNFPAMVWPDSIKIKNNKYN
GKKSPLIECLLGAKHYAKLFIILFNCYSNFEYA
SFTIL*VEKRSAPKKLELKQQLILPAPALAEASG
KDLNDTYWRITSTRGFKQTK*IITSVVPC*LYV
LRQRKATLRVS*PLLRKFTFILRVNYSGVLRCA
KGKET*IHQVKSC*TLS*AFFERLAYTKPCGRCF
PAISHLILTANL*NMALSSESHRSLVVYSRSYQ
LVNSRPRLETQDSLIPEPSLLVLRLVILSPKSK
GMTFIRGALLTIAAILTLKMIQNYQR**IRMT*L
SIISLALYCVCIAITGK*SSS*LLC*TMSLLFT
NLS*SKAVTMITLHIWES*VNYVSLCVYIYVCM
YLFSNCDLIFKYSYCHFCD*KTTHEETS*NFPIE
EK*HLGNLSCFTTVLIFLMICVAWNVFAQCEGF
SLLNFSV*VFSLR**TISKVTYWSWWLFLYRQL
L*DNDGALSMFNKCADGG
Frame 2
IWCS*WAGQSGPSSPERWSDPLGCSVDACATDVQA*GGSCPGRWQQ*QQQPPAPSWPRQGRSVWLC
TSQRHP*TSHLRAASAHAPINPSTVEFAWTIGA
ASPTSLRLSTCPSSVLMGLASPARSYGLMPASVT
*AVGIPMTSLLTWNPTLTSQKLPTRQAQILGLG
D*PNACEAVSPYGQ*LFTNEP*LP*SGPLASIS
VSNHSNDA*WCCSGPCYEFSP*YHSASTLKKNAC
L*LFWTTPKPDPAFPSH*KSCWILPKSQEMESG
RLLISLISSLDAKPQDSLGPFR*IDGIWNNRII
YYLEPAKRYCNG*F*RQRTKTILIPNMYAPQGHQ
TFAK*VE*LLNFDF*WKVVSINLGIVEVKFLFT
PTL*RVQIRFVPVRNKI**TFLLMGKAPS*YSR
DRERSARFRRTN*LSH*ISC*LAGLWAVGQALP*
IFSLVLLGVHRNW*GLWTGLSGP*EWCPGTLLY
SYRALRDPAADHARPTEMTKTGSGRGVGQTKKW
VPLVAAWGDL*SWRLWDSRGPRVQDTSIAETHFT
AFRSADQMASFLVGRWRFTGCLETEIDLIKV*S
*RG*S*KEKVVVNEYQAIIYCIRKI*YLLLEFF
YLGPFLCQTLLSVLCMY*LTESSRQC*EVPIIIS
VLTNVKRKLIEVRKLNQSHPVGDWES*DSDRNW
TVFITHIFPLFLELPNVSE*ENIAINGLIF*CH
FSLL*SF*LLFKRREYLIF**FRCLSIQNTWDTQ
KSRNPL*LIPSFPSEPALITHLKDDSVYPMLHI
ECCVVIHREFCAVCREIPKREKDWEYILLTVTS
PKPSPVQGIQWCSLNT**IQEAVHVFLLLFEALF
FQSYMKIEF*QSKFYIKCLSKRDI*YFKEMHMY
VYIYLCMRMQEFLYKENSLHE*SLL*VSVNHVR
FSESENTCHLQITRLDNSSLHLKFSGNPRARFLL
NLHLNLGN*T*LSKIIGSLVGETRDYSGNGCRK
VVRITQSPLVLRNGTILCRARRASLRPMG*SHG
EGNLDPM**SAF*VRISLQWCGLIQ*KLRIINIM
EKNLH*LSVYLVPSTMLSCSLFYLIVTAILSMH
LSLFYKWKREVPPKS*SSNSSLFYQPLLLRRPL
EKT*MTPIGELHLQGASNRPNRSSPLWSLVNYMF
*DKGKLP*GLVNLC*GNLHSYLE*ITQVCLGVQ
KGRRPEFTKLNLAKPYHKHFLSA*HTPSLVEGA
FLPYLI*SSQQTYRIWHYHLSLTEV*SCTQGLTS
**TADQDWKPRIV*YLSHLFLCYA*LFCPPNQK
A*PL*EALY*Q*LQF*L*K*FRIIKDSRFE*HD
CL*SR*PCTVCA*QLQGSNLAPDYYVELCRCFLQ
TCLDPKQSQ**PCISGNHKSTMYPCVCIYMYVC
IYFQTVI*YLNIPTAIFVTEKLHMRKRLRIFQ*
RKNNTWAICHVSQQFSFFS*FV*RGMCLLNVKGF
HCSISLCKSFP*GNKPSAKSHTGVGGFSCTGSC
YETMMEH*ACSINVQMVE
Sequence WISP1.cAug05
ATATCTGGTGCTCCTGATGGGCCGGCCAGTCTGGGCCCAGCTCCCCCGAGAGGTGGTCGGATCCTCTGGGCTGCTCGGTCGATGCCTGTGCCACTGACGTCCAGGCATGAGGTGGTTCCTGCCCTGGACGCTGGCAGCAGTGACAGCAGCAGCCGCCAGCACCGTCCTGGCCACGATGCTGTGGGTGAGGTGGAGGCATG
GCACAGGAACTGCATAGCCTACACAAGCCCCTGGAGCCCTTGCTCCACCAGCTGCGGCCTGGGGGTCTCCACTCGGATCTCCAATGTTAACGCCCAGTGC
TGGCCTGAGCAAGAGAGCCGCCTCTGCAACTTGCGGCCATGCGATGTGGACATCCATACACTCATTAAGGCAGGGAAGAAGTGTCTGGCTGTGTACCAGC
CAGAGGCATCCATGAACTTCACACTTGCGGGCTGCATCAGCACACGCTCCTATCAACCCAAGTACTGTGGAGTTTGCATGGACAATAGGTGCTGCATCCC
CTACAAGTCTAAGACTATCGACGTGTCCTTCCAGTGTCCTGATGGGCTTGGCTTCTCCCGCCAGGTCCTATGGATTAATGCCTGCTTCTGTAACCTGAGC
TGTAGGAATCCCAATGACATCTTTGCTGACTTGGAATCCTACCCTGACTTCTCAGAAATTGCCAACTAGGCAGGCACAAATCTTGGGTCTTGGGGACTAA
CCCAATGCCTGTGAAGCAGTCAGCCCTTATGGCCAATAACTTTTCACCAATGAGCCTTAGTTACCCTGATCTGGACCCTTGGCCTCCATTTCTGTCTCTA
ACCATTCAAATGACGCCTGATGGTGCTGCTCAGGCCCATGCTATGAGTTTTCTCCTTGATATCATTCAGCATCTACTCTAAAGAAAAATGCCTGTCTCTA
GCTGTTCTGGACTACACCCAAGCCTGATCCAGCCTTTCCAAGTCACTAGAAGTCCTGCTGGATCTTGCCTAAATCCCAAGAAATGGAATCAGGTAGACTT
TTAATATCACTAATTTCTTCTTTAGATGCCAAACCACAAGACTCTTTGGGTCCATTCAGATGAATAGATGGAATTTGGAACAATAGAATAATCTATTATT
TGGAGCCTGCCAAGAGGTACTGTAATGGGTAATTCTGACGTCAGCGCACCAAAACTATCCTGATTCCAAATATGTATGCACCTCAAGGTCATCAAACATT
TGCCAAGTGAGTTGAATAGTTGCTTAATTTTGATTTTTAATGGAAAGTTGTATCCATTAACCTGGGCATTGTTGAGGTTAAGTTTCTCTTCACCCCTACA
CTGTGAAGGGTACAGATTAGGTTTGTCCCAGTCAGAAATAAAATTTGATAAACATTCCTGTTGATGGGAAAAGCCCCCAGTTAATACTCCAGAGACAGGG
AAAGGTCAGCCCGTTTCAGAAGGACCAATTGACTCTCACACTGAATCAGCTGCTGACTGGCAGGGCTTTGGGCAGTTGGCCAGGCTCTTCCTTGAATCTT
CTCCCTTGTCCTGCTTGGGGTTCATAGGAATTGGTAAGGCCTCTGGACTGGCCTGTCTGGCCCCTGAGAGTGGTGCCCTGGAACACTCCTCTACTCTTAC
AGAGCCTTGAGAGACCCAGCTGCAGACCATGCCAGACCCACTGAAATGACCAAGACAGGTTCAGGTAGGGGTGTGGGTCAAACCAAGAAGTGGGTGCCCT
TGGTAGCAGCCTGGGGTGACCTCTAGAGCTGGAGGCTGTGGGACTCCAGGGGCCCCCGTGTTCAGGACACATCTATTGCAGAGACTCATTTCACAGCCTT
TCGTTCTGCTGACCAAATGGCCAGTTTTCTGGTAGGAAGATGGAGGTTTACCGGTTGTTTAGAAACAGAAATAGACTTAATAAAGGTTTAAAGCTGAAGA
GGTTGAAGCTAAAAGGAAAAGGTTGTTGTTAATGAATATCAGGCTATTATTTATTGTATTAGGAAAATATAATATTTACTGTTAGAATTCTTTTATTTAG
GGCCTTTTCTGTGCCAGACATTGCTCTCAGTGCTTTGCATGTATTAGCTCACTGAATCTTCACGACAATGTTGAGAAGTTCCCATTATTATTTCTGTTCT
TACAAATGTGAAACGGAAGCTCATAGAGGTGAGAAAACTCAACCAGAGTCACCCAGTTGGTGACTGGGAAAGTTAGGATTCAGATCGAAATTGGACTGTC
TTTATAACCCATATTTTCCCCCTGTTTTTAGAGCTTCCAAATGTGTCAGAATAGGAAAACATTGCAATAAATGGCTTGATTTTTTAATGTCATTTTTCCC
TCTTATAGTCTTTCTAGCTCCTTTTCAAAAGACGAGAATATCTGATTTTCTGATAATTTAGGTGCTTAAGCATCCAAAATACATGGGACACACAAAAATC
CAGGAATCCCCTGTAGCTTATTCCCTCTTTCCCATCGGAACCAGCTCTCATCACACATTTAAAAGATGATTCTGTTTACCCAATGCTGCATATTGAATGT
TGTGTAGTTATTCACAGGGAATTCTGTGCAGTGTGCAGAGAGATTCCTAAACGGGAAAAGGACTGGGAATACATCCTCCTTACTGTGACCTCCCCAAAAC
CTAGTCCAGTGCAAGGTATACAGTGGTGCTCATTAAATACTTGATGAATACAGGAAGCTGTGCATGTGTTCCTACTTTTATTCGAAGCTCTCTTCTTCCA
AAGCTACATGAAAATAGAATTTTAACAGTCAAAATTTTATATTAAGTGCCTTAGCAAAAGAGACATTTAATATTTCAAAGAAATGCATATGTATGTATAC
ATATATTTGTGTATGCGTATGCAAGAATTCTTGTATAAAGAGAATTCACTCCATGAATGATCTCTTCTGTAAGTCAGTGTGAATCATGTTAGATTTTCTG
AGAGTGAAAACACCTGCCATCTACAAATTACAAGGCTGGATAACAGCTCACTCCATTTGAAATTCAGTGGAAACCCAAGAGCTAGGTTCTTACTGAATTT
GCATCTCAATTTGGGAAACTGAACTTAGCTTTCAAAGATCATAGGAAGTCTGGTTGGAGAAACTAGGGATTATTCTGGCAATGGGTGCAGGAAGGTGGTC
AGAATAACCCAGTCGCCATTGGTTTTGAGAAACGGAACTATCTTATGCAGAGCCCGGAGGGCAAGTCTCAGACCCATGGGTTGAAGCCATGGAGAAGGAA
ATTTGGATCCAATGTAATGAAGCGCTTTCTAAGTCAGAATTTCCCTGCAATGGTGTGGCCTGATTCAATAAAAATTAAGAATAATAAATATAATGGAAAA
AAATCTCCACTGATTGAGTGTTTACTTGGTGCCAAGCACTATGCTAAGTTGTTCATTATTTTATTTAATTGTTACAGCAATTTTGAGTATGCATCTTTCA
CTATTTTATAAGTGGAAAAGAGAAGTGCCCCCAAAAAGTTAGAGCTCAAACAGCAGCTTATTCTACCAGCCCCTGCTCTTGCGGAGGCCTCTGGAAAAGA
CCTGAATGACACCTATTGGAGAATTACATCTACAAGGGGCTTCAAACAGACCAAATAGATCATCACCTCTGTGGTCCCTTGTTAACTATATGTTCTGAGA
CAAAGGAAAGCTACCCTAAGGGTTAGTTAACCTTTGCTGAGGAAATTTACATTCATACTTAGAGTGAATTACTCAGGTGTGCTTAGGTGTGCAAAAGGGA
AGGAGACCTGAATTCACCAAGTTAAATCTTGCTAAACCTTATCATAAGCATTTTTTGAGCGCTTAGCATACACCAAGCCTTGTGGAAGGTGCTTTCCTGC
CATATCTCATTTAATCCTCACAGCAAACCTATAGAATATGGCATTATCATCTGAGTCTCACAGAAGTTTAGTCGTGTACTCAAGGTCTTACCAGCTAGTG
AACAGCAGACCAAGACTGGAAACCCAGGATAGTCTGATACCTGAGCCATCTCTTCTTGTGCTACGCCTAGTTATTCTGTCCCCCAAATCAAAAGGCATGA
CCTTTATAAGAGGCGCTTTACTGACAATAGCTGCAATTTTAACTTTGAAAATGATTCAGAATTATCAAAGATAGTAGATTCGAATGACATGATTGTCTAT
AATCTCGCTAGCCTTGTACTGTGTGTGCATAGCAATTACAGGGAAGTAATCTAGCTCCTGACTATTATGTTGAACTATGTCGCTGCTTTTTACAAACTTG
TCTTGATCCAAAGCAGTCACAATGATAACCCTGCATATCTGGGAATCATAAGTCAACTATGTATCCCTGTGTGTGTATATATATGTATGTATGTATCTAT
TTTCAAACTGTGATTTAATATTTAAATATTCCTACTGCCATTTTTGTGACTGAAAAACTACACATGAGGAAACGTCTTAGAATTTTCCAATAGAGGAAAA
ATAACACTTGGGCAATCTGTCATGTTTCACAACAGTTCTCATTTTTCTCATGATTTGTGTAGCGTGGAATGTGTTTGCTCAATGTGAAGGGTTTTCATTG
CTCAATTTCTCTGTGTAAGTCTTTTCCTTAAGGTAATAAACCATCAGCAAAGTCACATACTGGAGTTGGTGGCTTTTCTTGTACAGGCAGTTGTTATGAG
ACAATGATGGAGCATTGAGCATGTTCAATAAATGTGCAGATGGTGGAAA
- WISP1.u.f.1 (forward primer)
- WISP1.u.r.4 (reverse primer)
- Single exon skipping
Frame 0
ISGAPDGPASLGPAPPRGGRILWAARSMPVPLTSRHEVVPALDAGSSDSSSRQHRPGHDAVGEVEAW
HRNCIAYTSPWSPCSTSCGLGVSTRISNVNAQC
WPEQESRLCNLRPCDVDIHTLIKAGKKCLAVYQ
PEASMNFTLAGCISTRSYQPKYCGVCMDNRCCIP
YKSKTIDVSFQCPDGLGFSRQVLWINACFCNLS
CRNPNDIFADLESYPDFSEIAN*AGTNLGSWGL
TQCL*SSQPLWPITFHQ*ALVTLIWTLGLHFCL*
PFK*RLMVLLRPML*VFSLISFSIYSKEKCLSL
AVLDYTQA*SSLSKSLEVLLDLA*IPRNGIR*T
FNITNFFFRCQTTRLFGSIQMNRWNLEQ*NNLLF
GACQEVL*WVILTSAHQNYPDSKYVCTSRSSNI
CQVS*IVA*F*FLMESCIH*PGHC*G*VSLHPY
TVKGTD*VCPSQK*NLINIPVDGKSPQLILQRQG
KVSPFQKDQLTLTLNQLLTGRALGSWPGSSLNL
LPCPAWGS*ELVRPLDWPVWPLRVVPWNTPLLL
QSLERPSCRPCQTH*NDQDRFR*GCGSNQEVGAL
GSSLG*PLELEAVGLQGPPCSGHIYCRDSFHSL
SFC*PNGQFSGRKMEVYRLFRNRNRLNKGLKLK
RLKLKGKGCC**ISGYYLLY*ENIIFTVRILLFR
AFSVPDIALSALHVLAH*IFTTMLRSSHYYFCS
YKCETEAHRGEKTQPESPSW*LGKLGFRSKLDC
LYNPYFPPVFRASKCVRIGKHCNKWLDFLMSFFP
LIVFLAPFQKTRISDFLII*VLKHPKYMGHTKI
QESPVAYSLFPIGTSSHHTFKR*FCLPNAAY*M
LCSYSQGILCSVQRDS*TGKGLGIHPPYCDLPKT
*SSARYTVVLIKYLMNTGSCACVPTFIRSSLLP
KLHENRILTVKILY*VP*QKRHLIFQRNAYVCI
HIFVYAYARILV*REFTP*MISSVSQCESC*IF*
E*KHLPSTNYKAG*QLTPFEIQWKPKS*VLTEF
ASQFGKLNLAFKDHRKSGWRN*GLFWQWVQEGG
QNNPVAIGFEKRNYLMQSPEGKSQTHGLKPWRRK
FGSNVMKRFLSQNFPAMVWPDSIKIKNNKYNGK
KSPLIECLLGAKHYAKLFIILFNCYSNFEYASF
TIL*VEKRSAPKKLELKQQLILPAPALAEASGKD
LNDTYWRITSTRGFKQTK*IITSVVPC*LYVLR
QRKATLRVS*PLLRKFTFILRVNYSGVLRCAKG
KET*IHQVKSC*TLS*AFFERLAYTKPCGRCFPA
ISHLILTANL*NMALSSESHRSLVVYSRSYQLV
NSRPRLETQDSLIPEPSLLVLRLVILSPKSKGM
TFIRGALLTIAAILTLKMIQNYQR**IRMT*LSI
ISLALYCVCIAITGK*SSS*LLC*TMSLLFTNL
S*SKAVTMITLHIWES*VNYVSLCVYIYVCMYL
FSNCDLIFKYSYCHFCD*KTTHEETS*NFPIEEK
*HLGNLSCFTTVLIFLMICVAWNVFAQCEGFSL
LNFSV*VFSLR**TISKVTYWSWWLFLYRQLL*
DNDGALSMFNKCADGG
Frame 1
YLVLLMGRPVWAQLPREVVGSSGLLGRCLCH*RPGMRWFLPWTLAAVTAAAASTVLATMLWVRWRH
GTGTA*PTQAPGALAPPAAAWGSPLGSPMLTPSA
GLSKRAASATCGHAMWTSIHSLRQGRSVWLCTS
QRHP*TSHLRAASAHAPINPSTVEFAWTIGAAS
PTSLRLSTCPSSVLMGLASPARSYGLMPASVT*A
VGIPMTSLLTWNPTLTSQKLPTRQAQILGLGD*
PNACEAVSPYGQ*LFTNEP*LP*SGPLASISVS
NHSNDA*WCCSGPCYEFSP*YHSASTLKKNACL*
LFWTTPKPDPAFPSH*KSCWILPKSQEMESGRL
LISLISSLDAKPQDSLGPFR*IDGIWNNRIIYY
LEPAKRYCNG*F*RQRTKTILIPNMYAPQGHQTF
AK*VE*LLNFDF*WKVVSINLGIVEVKFLFTPT
L*RVQIRFVPVRNKI**TFLLMGKAPS*YSRDR
ERSARFRRTN*LSH*ISC*LAGLWAVGQALP*IF
SLVLLGVHRNW*GLWTGLSGP*EWCPGTLLYSY
RALRDPAADHARPTEMTKTGSGRGVGQTKKWVP
LVAAWGDL*SWRLWDSRGPRVQDTSIAETHFTAF
RSADQMASFLVGRWRFTGCLETEIDLIKV*S*R
G*S*KEKVVVNEYQAIIYCIRKI*YLLLEFFYL
GPFLCQTLLSVLCMY*LTESSRQC*EVPIIISVL
TNVKRKLIEVRKLNQSHPVGDWES*DSDRNWTV
FITHIFPLFLELPNVSE*ENIAINGLIF*CHFS
LL*SF*LLFKRREYLIF**FRCLSIQNTWDTQKS
RNPL*LIPSFPSEPALITHLKDDSVYPMLHIEC
CVVIHREFCAVCREIPKREKDWEYILLTVTSPK
PSPVQGIQWCSLNT**IQEAVHVFLLLFEALFFQ
SYMKIEF*QSKFYIKCLSKRDI*YFKEMHMYVY
IYLCMRMQEFLYKENSLHE*SLL*VSVNHVRFS
ESENTCHLQITRLDNSSLHLKFSGNPRARFLLNL
HLNLGN*T*LSKIIGSLVGETRDYSGNGCRKVV
RITQSPLVLRNGTILCRARRASLRPMG*SHGEG
NLDPM**SAF*VRISLQWCGLIQ*KLRIINIMEK
NLH*LSVYLVPSTMLSCSLFYLIVTAILSMHLS
LFYKWKREVPPKS*SSNSSLFYQPLLLRRPLEK
T*MTPIGELHLQGASNRPNRSSPLWSLVNYMF*D
KGKLP*GLVNLC*GNLHSYLE*ITQVCLGVQKG
RRPEFTKLNLAKPYHKHFLSA*HTPSLVEGAFL
PYLI*SSQQTYRIWHYHLSLTEV*SCTQGLTS**
TADQDWKPRIV*YLSHLFLCYA*LFCPPNQKA*
PL*EALY*Q*LQF*L*K*FRIIKDSRFE*HDCL
*SR*PCTVCA*QLQGSNLAPDYYVELCRCFLQTC
LDPKQSQ**PCISGNHKSTMYPCVCIYMYVCIY
FQTVI*YLNIPTAIFVTEKLHMRKRLRIFQ*RK
NNTWAICHVSQQFSFFS*FV*RGMCLLNVKGFHC
SISLCKSFP*GNKPSAKSHTGVGGFSCTGSCYE
TMMEH*ACSINVQMVE
Frame 2
IWCS*WAGQSGPSSPERWSDPLGCSVDACATDVQA*GGSCPGRWQQ*QQQPPAPSWPRCCG*GGGM
AQELHSLHKPLEPLLHQLRPGGLHSDLQC*RPV
LA*AREPPLQLAAMRCGHPYTH*GREEVSGCVPA
RGIHELHTCGLHQHTLLSTQVLWSLHGQ*VLHP
LQV*DYRRVLPVS*WAWLLPPGPMD*CLLL*PE
L*ESQ*HLC*LGILP*LLRNCQLGRHKSWVLGTN
PMPVKQSALMANNFSPMSLSYPDLDPWPPFLSL
TIQMTPDGAAQAHAMSFLLDIIQHLL*RKMPVS
SCSGLHPSLIQPFQVTRSPAGSCLNPKKWNQVDF
*YH*FLL*MPNHKTLWVHSDE*MEFGTIE*SII
WSLPRGTVMGNSDVSAPKLS*FQICMHLKVIKH
LPSELNSCLILIFNGKLYPLTWALLRLSFSSPLH
CEGYRLGLSQSEIKFDKHSC*WEKPPVNTPETG
KGQPVSEGPIDSHTESAADWQGFGQLARLFLES
SPLSCLGFIGIGKASGLACLAPESGALEHSSTLT
EP*ETQLQTMPDPLK*PRQVQVGVWVKPRSGCP
W*QPGVTSRAGGCGTPGAPVFRTHLLQRLISQP
FVLLTKWPVFW*EDGGLPVV*KQK*T**RFKAEE
VEAKRKRLLLMNIRLLFIVLGKYNIYC*NSFI*
GLFCARHCSQCFACISSLNLHDNVEKFPLLFLF
LQM*NGSS*R*ENSTRVTQLVTGKVRIQIEIGLS
L*PIFSPCF*SFQMCQNRKTLQ*MA*FFNVIFP
SYSLSSSFSKDENI*FSDNLGA*ASKIHGTHKN
PGIPCSLFPLSHRNQLSSHI*KMILFTQCCILNV
V*LFTGNSVQCAERFLNGKRTGNTSSLL*PPQN
LVQCKVYSGAH*ILDEYRKLCMCSYFYSKLSSS
KAT*K*NFNSQNFILSALAKETFNISKKCICMYT
YICVCVCKNSCIKRIHSMNDLFCKSV*IMLDFL
RVKTPAIYKLQGWITAHSI*NSVETQELGSY*I
CISIWETELSFQRS*EVWLEKLGIILAMGAGRWS
E*PSRHWF*ETELSYAEPGGQVSDPWVEAMEKE
IWIQCNEALSKSEFPCNGVA*FNKN*E**I*WK
KISTD*VFTWCQALC*VVHYFI*LLQQF*VCIFH
YFISGKEKCPQKVRAQTAAYSTSPCSCGGLWKR
PE*HLLENYIYKGLQTDQIDHHLCGPLLTICSE
TKESYPKG*LTFAEEIYIHT*SELLRCA*VCKRE
GDLNSPS*ILLNLIISIF*ALSIHQALWKVLSC
HISFNPHSKPIEYGIII*VSQKFSRVLKVLPAS
EQQTKTGNPG*SDT*AISSCATPSYSVPQIKRHD
LYKRRFTDNSCNFNFENDSELSKIVDSNDMIVY
NLASLVLCVHSNYREVI*LLTIMLNYVAAFYKL
VLIQSSHNDNPAYLGIISQLCIPVCVYICMYVSI
FKL*FNI*IFLLPFL*LKNYT*GNVLEFSNRGK
ITLGQSVMFHNSSHFSHDLCSVECVCSM*RVFI
AQFLCVSLFLKVINHQQSHILELVAFLVQAVVMR
Q*WSIEHVQ*MCRWWK
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