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Sequences

Sequence WISP1.eAug05

ATATCTGGTGCTCCTGATGGGCCGGCCAGTCTGGGCCCAGCTCCCCCGAGAGGTGGTCGGATCCTCTGGGCTGCTCGGTCGATGCCTGTGCCACTGACGT CCAGGCATGAGGTGGTTCCTGCCCTGGACGCTGGCAGCAGTGACAGCAGCAGCCGCCAGCACCGTCCTGGCCACGGCAGGGAAGAAGTGTCTGGCTGTGT ACCAGCCAGAGGCATCCATGAACTTCACACTTGCGGGCTGCATCAGCACACGCTCCTATCAACCCAAGTACTGTGGAGTTTGCATGGACAATAGGTGCTG CATCCCCTACAAGTCTAAGACTATCGACGTGTCCTTCCAGTGTCCTGATGGGCTTGGCTTCTCCCGCCAGGTCCTATGGATTAATGCCTGCTTCTGTAAC CTGAGCTGTAGGAATCCCAATGACATCTTTGCTGACTTGGAATCCTACCCTGACTTCTCAGAAATTGCCAACTAGGCAGGCACAAATCTTGGGTCTTGGG GACTAACCCAATGCCTGTGAAGCAGTCAGCCCTTATGGCCAATAACTTTTCACCAATGAGCCTTAGTTACCCTGATCTGGACCCTTGGCCTCCATTTCTG TCTCTAACCATTCAAATGACGCCTGATGGTGCTGCTCAGGCCCATGCTATGAGTTTTCTCCTTGATATCATTCAGCATCTACTCTAAAGAAAAATGCCTG TCTCTAGCTGTTCTGGACTACACCCAAGCCTGATCCAGCCTTTCCAAGTCACTAGAAGTCCTGCTGGATCTTGCCTAAATCCCAAGAAATGGAATCAGGT AGACTTTTAATATCACTAATTTCTTCTTTAGATGCCAAACCACAAGACTCTTTGGGTCCATTCAGATGAATAGATGGAATTTGGAACAATAGAATAATCT ATTATTTGGAGCCTGCCAAGAGGTACTGTAATGGGTAATTCTGACGTCAGCGCACCAAAACTATCCTGATTCCAAATATGTATGCACCTCAAGGTCATCA AACATTTGCCAAGTGAGTTGAATAGTTGCTTAATTTTGATTTTTAATGGAAAGTTGTATCCATTAACCTGGGCATTGTTGAGGTTAAGTTTCTCTTCACC CCTACACTGTGAAGGGTACAGATTAGGTTTGTCCCAGTCAGAAATAAAATTTGATAAACATTCCTGTTGATGGGAAAAGCCCCCAGTTAATACTCCAGAG ACAGGGAAAGGTCAGCCCGTTTCAGAAGGACCAATTGACTCTCACACTGAATCAGCTGCTGACTGGCAGGGCTTTGGGCAGTTGGCCAGGCTCTTCCTTG AATCTTCTCCCTTGTCCTGCTTGGGGTTCATAGGAATTGGTAAGGCCTCTGGACTGGCCTGTCTGGCCCCTGAGAGTGGTGCCCTGGAACACTCCTCTAC TCTTACAGAGCCTTGAGAGACCCAGCTGCAGACCATGCCAGACCCACTGAAATGACCAAGACAGGTTCAGGTAGGGGTGTGGGTCAAACCAAGAAGTGGG TGCCCTTGGTAGCAGCCTGGGGTGACCTCTAGAGCTGGAGGCTGTGGGACTCCAGGGGCCCCCGTGTTCAGGACACATCTATTGCAGAGACTCATTTCAC AGCCTTTCGTTCTGCTGACCAAATGGCCAGTTTTCTGGTAGGAAGATGGAGGTTTACCGGTTGTTTAGAAACAGAAATAGACTTAATAAAGGTTTAAAGC TGAAGAGGTTGAAGCTAAAAGGAAAAGGTTGTTGTTAATGAATATCAGGCTATTATTTATTGTATTAGGAAAATATAATATTTACTGTTAGAATTCTTTT ATTTAGGGCCTTTTCTGTGCCAGACATTGCTCTCAGTGCTTTGCATGTATTAGCTCACTGAATCTTCACGACAATGTTGAGAAGTTCCCATTATTATTTC TGTTCTTACAAATGTGAAACGGAAGCTCATAGAGGTGAGAAAACTCAACCAGAGTCACCCAGTTGGTGACTGGGAAAGTTAGGATTCAGATCGAAATTGG ACTGTCTTTATAACCCATATTTTCCCCCTGTTTTTAGAGCTTCCAAATGTGTCAGAATAGGAAAACATTGCAATAAATGGCTTGATTTTTTAATGTCATT TTTCCCTCTTATAGTCTTTCTAGCTCCTTTTCAAAAGACGAGAATATCTGATTTTCTGATAATTTAGGTGCTTAAGCATCCAAAATACATGGGACACACA AAAATCCAGGAATCCCCTGTAGCTTATTCCCTCTTTCCCATCGGAACCAGCTCTCATCACACATTTAAAAGATGATTCTGTTTACCCAATGCTGCATATT GAATGTTGTGTAGTTATTCACAGGGAATTCTGTGCAGTGTGCAGAGAGATTCCTAAACGGGAAAAGGACTGGGAATACATCCTCCTTACTGTGACCTCCC CAAAACCTAGTCCAGTGCAAGGTATACAGTGGTGCTCATTAAATACTTGATGAATACAGGAAGCTGTGCATGTGTTCCTACTTTTATTCGAAGCTCTCTT CTTCCAAAGCTACATGAAAATAGAATTTTAACAGTCAAAATTTTATATTAAGTGCCTTAGCAAAAGAGACATTTAATATTTCAAAGAAATGCATATGTAT GTATACATATATTTGTGTATGCGTATGCAAGAATTCTTGTATAAAGAGAATTCACTCCATGAATGATCTCTTCTGTAAGTCAGTGTGAATCATGTTAGAT TTTCTGAGAGTGAAAACACCTGCCATCTACAAATTACAAGGCTGGATAACAGCTCACTCCATTTGAAATTCAGTGGAAACCCAAGAGCTAGGTTCTTACT GAATTTGCATCTCAATTTGGGAAACTGAACTTAGCTTTCAAAGATCATAGGAAGTCTGGTTGGAGAAACTAGGGATTATTCTGGCAATGGGTGCAGGAAG GTGGTCAGAATAACCCAGTCGCCATTGGTTTTGAGAAACGGAACTATCTTATGCAGAGCCCGGAGGGCAAGTCTCAGACCCATGGGTTGAAGCCATGGAG AAGGAAATTTGGATCCAATGTAATGAAGCGCTTTCTAAGTCAGAATTTCCCTGCAATGGTGTGGCCTGATTCAATAAAAATTAAGAATAATAAATATAAT GGAAAAAAATCTCCACTGATTGAGTGTTTACTTGGTGCCAAGCACTATGCTAAGTTGTTCATTATTTTATTTAATTGTTACAGCAATTTTGAGTATGCAT CTTTCACTATTTTATAAGTGGAAAAGAGAAGTGCCCCCAAAAAGTTAGAGCTCAAACAGCAGCTTATTCTACCAGCCCCTGCTCTTGCGGAGGCCTCTGG AAAAGACCTGAATGACACCTATTGGAGAATTACATCTACAAGGGGCTTCAAACAGACCAAATAGATCATCACCTCTGTGGTCCCTTGTTAACTATATGTT CTGAGACAAAGGAAAGCTACCCTAAGGGTTAGTTAACCTTTGCTGAGGAAATTTACATTCATACTTAGAGTGAATTACTCAGGTGTGCTTAGGTGTGCAA AAGGGAAGGAGACCTGAATTCACCAAGTTAAATCTTGCTAAACCTTATCATAAGCATTTTTTGAGCGCTTAGCATACACCAAGCCTTGTGGAAGGTGCTT TCCTGCCATATCTCATTTAATCCTCACAGCAAACCTATAGAATATGGCATTATCATCTGAGTCTCACAGAAGTTTAGTCGTGTACTCAAGGTCTTACCAG CTAGTGAACAGCAGACCAAGACTGGAAACCCAGGATAGTCTGATACCTGAGCCATCTCTTCTTGTGCTACGCCTAGTTATTCTGTCCCCCAAATCAAAAG GCATGACCTTTATAAGAGGCGCTTTACTGACAATAGCTGCAATTTTAACTTTGAAAATGATTCAGAATTATCAAAGATAGTAGATTCGAATGACATGATT GTCTATAATCTCGCTAGCCTTGTACTGTGTGTGCATAGCAATTACAGGGAAGTAATCTAGCTCCTGACTATTATGTTGAACTATGTCGCTGCTTTTTACA AACTTGTCTTGATCCAAAGCAGTCACAATGATAACCCTGCATATCTGGGAATCATAAGTCAACTATGTATCCCTGTGTGTGTATATATATGTATGTATGT ATCTATTTTCAAACTGTGATTTAATATTTAAATATTCCTACTGCCATTTTTGTGACTGAAAAACTACACATGAGGAAACGTCTTAGAATTTTCCAATAGA GGAAAAATAACACTTGGGCAATCTGTCATGTTTCACAACAGTTCTCATTTTTCTCATGATTTGTGTAGCGTGGAATGTGTTTGCTCAATGTGAAGGGTTT TCATTGCTCAATTTCTCTGTGTAAGTCTTTTCCTTAAGGTAATAAACCATCAGCAAAGTCACATACTGGAGTTGGTGGCTTTTCTTGTACAGGCAGTTGT TATGAGACAATGATGGAGCATTGAGCATGTTCAATAAATGTGCAGATGGTGGAAA

WISP1.u.f.1 (forward primer)
WISP1.u.r.4 (reverse primer)
Multiple exon skipping

Frame 0

ISGAPDGPASLGPAPPRGGRILWAARSMPVPLT SRHEVVPALDAGSSDSSSRQHRPGHGREEVSGCV PARGIHELHTCGLHQHTLLSTQVLWSLHGQ*VL HPLQV*DYRRVLPVS*WAWLLPPGPMD*CLLL* PEL*ESQ*HLC*LGILP*LLRNCQLGRHKSWVLG TNPMPVKQSALMANNFSPMSLSYPDLDPWPPFL SLTIQMTPDGAAQAHAMSFLLDIIQHLL*RKMP VSSCSGLHPSLIQPFQVTRSPAGSCLNPKKWNQV DF*YH*FLL*MPNHKTLWVHSDE*MEFGTIE*S IIWSLPRGTVMGNSDVSAPKLS*FQICMHLKVI KHLPSELNSCLILIFNGKLYPLTWALLRLSFSSP LHCEGYRLGLSQSEIKFDKHSC*WEKPPVNTPE TGKGQPVSEGPIDSHTESAADWQGFGQLARLFL ESSPLSCLGFIGIGKASGLACLAPESGALEHSST LTEP*ETQLQTMPDPLK*PRQVQVGVWVKPRSG CPW*QPGVTSRAGGCGTPGAPVFRTHLLQRLIS QPFVLLTKWPVFW*EDGGLPVV*KQK*T**RFKA EEVEAKRKRLLLMNIRLLFIVLGKYNIYC*NSF I*GLFCARHCSQCFACISSLNLHDNVEKFPLLF LFLQM*NGSS*R*ENSTRVTQLVTGKVRIQIEIG LSL*PIFSPCF*SFQMCQNRKTLQ*MA*FFNVI FPSYSLSSSFSKDENI*FSDNLGA*ASKIHGTH KNPGIPCSLFPLSHRNQLSSHI*KMILFTQCCIL NVV*LFTGNSVQCAERFLNGKRTGNTSSLL*PP QNLVQCKVYSGAH*ILDEYRKLCMCSYFYSKLS SSKAT*K*NFNSQNFILSALAKETFNISKKCICM YTYICVCVCKNSCIKRIHSMNDLFCKSV*IMLD FLRVKTPAIYKLQGWITAHSI*NSVETQELGSY *ICISIWETELSFQRS*EVWLEKLGIILAMGAGR WSE*PSRHWF*ETELSYAEPGGQVSDPWVEAME KEIWIQCNEALSKSEFPCNGVA*FNKN*E**I* WKKISTD*VFTWCQALC*VVHYFI*LLQQF*VCI FHYFISGKEKCPQKVRAQTAAYSTSPCSCGGLW KRPE*HLLENYIYKGLQTDQIDHHLCGPLLTIC SETKESYPKG*LTFAEEIYIHT*SELLRCA*VCK REGDLNSPS*ILLNLIISIF*ALSIHQALWKVL SCHISFNPHSKPIEYGIII*VSQKFSRVLKVLP ASEQQTKTGNPG*SDT*AISSCATPSYSVPQIKR HDLYKRRFTDNSCNFNFENDSELSKIVDSNDMI VYNLASLVLCVHSNYREVI*LLTIMLNYVAAFY KLVLIQSSHNDNPAYLGIISQLCIPVCVYICMYV SIFKL*FNI*IFLLPFL*LKNYT*GNVLEFSNR GKITLGQSVMFHNSSHFSHDLCSVECVCSM*RV FIAQFLCVSLFLKVINHQQSHILELVAFLVQAVV MRQ*WSIEHVQ*MCRWWK

Frame 1

YLVLLMGRPVWAQLPREVVGSSGLLGRCLCH*R PGMRWFLPWTLAAVTAAAASTVLATAGKKCLAV YQPEASMNFTLAGCISTRSYQPKYCGVCMDNRCC IPYKSKTIDVSFQCPDGLGFSRQVLWINACFCN LSCRNPNDIFADLESYPDFSEIAN*AGTNLGSW GLTQCL*SSQPLWPITFHQ*ALVTLIWTLGLHFC L*PFK*RLMVLLRPML*VFSLISFSIYSKEKCL SLAVLDYTQA*SSLSKSLEVLLDLA*IPRNGIR *TFNITNFFFRCQTTRLFGSIQMNRWNLEQ*NNL LFGACQEVL*WVILTSAHQNYPDSKYVCTSRSS NICQVS*IVA*F*FLMESCIH*PGHC*G*VSLH PYTVKGTD*VCPSQK*NLINIPVDGKSPQLILQR QGKVSPFQKDQLTLTLNQLLTGRALGSWPGSSL NLLPCPAWGS*ELVRPLDWPVWPLRVVPWNTPL LLQSLERPSCRPCQTH*NDQDRFR*GCGSNQEVG ALGSSLG*PLELEAVGLQGPPCSGHIYCRDSFH SLSFC*PNGQFSGRKMEVYRLFRNRNRLNKGLK LKRLKLKGKGCC**ISGYYLLY*ENIIFTVRILL FRAFSVPDIALSALHVLAH*IFTTMLRSSHYYF CSYKCETEAHRGEKTQPESPSW*LGKLGFRSKL DCLYNPYFPPVFRASKCVRIGKHCNKWLDFLMSF FPLIVFLAPFQKTRISDFLII*VLKHPKYMGHT KIQESPVAYSLFPIGTSSHHTFKR*FCLPNAAY *MLCSYSQGILCSVQRDS*TGKGLGIHPPYCDLP KT*SSARYTVVLIKYLMNTGSCACVPTFIRSSL LPKLHENRILTVKILY*VP*QKRHLIFQRNAYV CIHIFVYAYARILV*REFTP*MISSVSQCESC*I F*E*KHLPSTNYKAG*QLTPFEIQWKPKS*VLT EFASQFGKLNLAFKDHRKSGWRN*GLFWQWVQE GGQNNPVAIGFEKRNYLMQSPEGKSQTHGLKPWR RKFGSNVMKRFLSQNFPAMVWPDSIKIKNNKYN GKKSPLIECLLGAKHYAKLFIILFNCYSNFEYA SFTIL*VEKRSAPKKLELKQQLILPAPALAEASG KDLNDTYWRITSTRGFKQTK*IITSVVPC*LYV LRQRKATLRVS*PLLRKFTFILRVNYSGVLRCA KGKET*IHQVKSC*TLS*AFFERLAYTKPCGRCF PAISHLILTANL*NMALSSESHRSLVVYSRSYQ LVNSRPRLETQDSLIPEPSLLVLRLVILSPKSK GMTFIRGALLTIAAILTLKMIQNYQR**IRMT*L SIISLALYCVCIAITGK*SSS*LLC*TMSLLFT NLS*SKAVTMITLHIWES*VNYVSLCVYIYVCM YLFSNCDLIFKYSYCHFCD*KTTHEETS*NFPIE EK*HLGNLSCFTTVLIFLMICVAWNVFAQCEGF SLLNFSV*VFSLR**TISKVTYWSWWLFLYRQL L*DNDGALSMFNKCADGG

Frame 2

IWCS*WAGQSGPSSPERWSDPLGCSVDACATDV QA*GGSCPGRWQQ*QQQPPAPSWPRQGRSVWLC TSQRHP*TSHLRAASAHAPINPSTVEFAWTIGA ASPTSLRLSTCPSSVLMGLASPARSYGLMPASVT *AVGIPMTSLLTWNPTLTSQKLPTRQAQILGLG D*PNACEAVSPYGQ*LFTNEP*LP*SGPLASIS VSNHSNDA*WCCSGPCYEFSP*YHSASTLKKNAC L*LFWTTPKPDPAFPSH*KSCWILPKSQEMESG RLLISLISSLDAKPQDSLGPFR*IDGIWNNRII YYLEPAKRYCNG*F*RQRTKTILIPNMYAPQGHQ TFAK*VE*LLNFDF*WKVVSINLGIVEVKFLFT PTL*RVQIRFVPVRNKI**TFLLMGKAPS*YSR DRERSARFRRTN*LSH*ISC*LAGLWAVGQALP* IFSLVLLGVHRNW*GLWTGLSGP*EWCPGTLLY SYRALRDPAADHARPTEMTKTGSGRGVGQTKKW VPLVAAWGDL*SWRLWDSRGPRVQDTSIAETHFT AFRSADQMASFLVGRWRFTGCLETEIDLIKV*S *RG*S*KEKVVVNEYQAIIYCIRKI*YLLLEFF YLGPFLCQTLLSVLCMY*LTESSRQC*EVPIIIS VLTNVKRKLIEVRKLNQSHPVGDWES*DSDRNW TVFITHIFPLFLELPNVSE*ENIAINGLIF*CH FSLL*SF*LLFKRREYLIF**FRCLSIQNTWDTQ KSRNPL*LIPSFPSEPALITHLKDDSVYPMLHI ECCVVIHREFCAVCREIPKREKDWEYILLTVTS PKPSPVQGIQWCSLNT**IQEAVHVFLLLFEALF FQSYMKIEF*QSKFYIKCLSKRDI*YFKEMHMY VYIYLCMRMQEFLYKENSLHE*SLL*VSVNHVR FSESENTCHLQITRLDNSSLHLKFSGNPRARFLL NLHLNLGN*T*LSKIIGSLVGETRDYSGNGCRK VVRITQSPLVLRNGTILCRARRASLRPMG*SHG EGNLDPM**SAF*VRISLQWCGLIQ*KLRIINIM EKNLH*LSVYLVPSTMLSCSLFYLIVTAILSMH LSLFYKWKREVPPKS*SSNSSLFYQPLLLRRPL EKT*MTPIGELHLQGASNRPNRSSPLWSLVNYMF *DKGKLP*GLVNLC*GNLHSYLE*ITQVCLGVQ KGRRPEFTKLNLAKPYHKHFLSA*HTPSLVEGA FLPYLI*SSQQTYRIWHYHLSLTEV*SCTQGLTS **TADQDWKPRIV*YLSHLFLCYA*LFCPPNQK A*PL*EALY*Q*LQF*L*K*FRIIKDSRFE*HD CL*SR*PCTVCA*QLQGSNLAPDYYVELCRCFLQ TCLDPKQSQ**PCISGNHKSTMYPCVCIYMYVC IYFQTVI*YLNIPTAIFVTEKLHMRKRLRIFQ* RKNNTWAICHVSQQFSFFS*FV*RGMCLLNVKGF HCSISLCKSFP*GNKPSAKSHTGVGGFSCTGSC YETMMEH*ACSINVQMVE

Sequence WISP1.aAug05

ATATCTGGTGCTCCTGATGGGCCGGCCAGTCTGGGCCCAGCTCCCCCGAGAGGTGGTCGGATCCTCTGGGCTGCTCGGTCGATGCCTGTGCCACTGACGT CCAGGCATGAGGTGGTTCCTGCCCTGGACGCTGGCAGCAGTGACAGCAGCAGCCGCCAGCACCGTCCTGGCCACGGCCCTCTCTCCAGCCCCTACGACCA TGGACTTTACCCCAGCTCCACTGGAGGACACCTCCTCACGCCCCCAATTCTGCAAGTGGCCATGTGAGTGCCCGCCATCCCCACCCCGCTGCCCGCTGGG GGTCAGCCTCATCACAGATGGCTGTGAGTGCTGTAAGATGTGCGCTCAGCAGCTTGGGGACAACTGCACGGAGGCTGCCATCTGTGACCCCCACCGGGGC CTCTACTGTGACTACAGCGGGGACCGCCCGAGGTACGCAATAGGAGTGTGTGCACAGGTGGTCGGTGTGGGCTGCGTCCTGGATGGGGTGCGCTACAACA ACGGCCAGTCCTTCCAGCCTAACTGCAAGTACAACTGCACGTGCATCGACGGCGCGGTGGGCTGCACACCACTGTGCCTCCGAGTGCGCCCCCCGCGTCT CTGGTGCCCCCACCCGCGGCGCGTGAGCATACCTGGCCACTGCTGTGAGCAGTGGGTATGTGAGGACGACGCCAAGAGGCCACGCAAGACCGCACCCCGT GACACAGGAGCCTTCGATGCTGTGGGTGAGGTGGAGGCATGGCACAGGAACTGCATAGCCTACACAAGCCCCTGGAGCCCTTGCTCCACCAGCTGCGGCC TGGGGGTCTCCACTCGGATCTCCAATGTTAACGCCCAGTGCTGGCCTGAGCAAGAGAGCCGCCTCTGCAACTTGCGGCCATGCGATGTGGACATCCATAC ACTCATTAAGGCAGGGAAGAAGTGTCTGGCTGTGTACCAGCCAGAGGCATCCATGAACTTCACACTTGCGGGCTGCATCAGCACACGCTCCTATCAACCC AAGTACTGTGGAGTTTGCATGGACAATAGGTGCTGCATCCCCTACAAGTCTAAGACTATCGACGTGTCCTTCCAGTGTCCTGATGGGCTTGGCTTCTCCC GCCAGGTCCTATGGATTAATGCCTGCTTCTGTAACCTGAGCTGTAGGAATCCCAATGACATCTTTGCTGACTTGGAATCCTACCCTGACTTCTCAGAAAT TGCCAACTAGGCAGGCACAAATCTTGGGTCTTGGGGACTAACCCAATGCCTGTGAAGCAGTCAGCCCTTATGGCCAATAACTTTTCACCAATGAGCCTTA GTTACCCTGATCTGGACCCTTGGCCTCCATTTCTGTCTCTAACCATTCAAATGACGCCTGATGGTGCTGCTCAGGCCCATGCTATGAGTTTTCTCCTTGA TATCATTCAGCATCTACTCTAAAGAAAAATGCCTGTCTCTAGCTGTTCTGGACTACACCCAAGCCTGATCCAGCCTTTCCAAGTCACTAGAAGTCCTGCT GGATCTTGCCTAAATCCCAAGAAATGGAATCAGGTAGACTTTTAATATCACTAATTTCTTCTTTAGATGCCAAACCACAAGACTCTTTGGGTCCATTCAG ATGAATAGATGGAATTTGGAACAATAGAATAATCTATTATTTGGAGCCTGCCAAGAGGTACTGTAATGGGTAATTCTGACGTCAGCGCACCAAAACTATC CTGATTCCAAATATGTATGCACCTCAAGGTCATCAAACATTTGCCAAGTGAGTTGAATAGTTGCTTAATTTTGATTTTTAATGGAAAGTTGTATCCATTA ACCTGGGCATTGTTGAGGTTAAGTTTCTCTTCACCCCTACACTGTGAAGGGTACAGATTAGGTTTGTCCCAGTCAGAAATAAAATTTGATAAACATTCCT GTTGATGGGAAAAGCCCCCAGTTAATACTCCAGAGACAGGGAAAGGTCAGCCCGTTTCAGAAGGACCAATTGACTCTCACACTGAATCAGCTGCTGACTG GCAGGGCTTTGGGCAGTTGGCCAGGCTCTTCCTTGAATCTTCTCCCTTGTCCTGCTTGGGGTTCATAGGAATTGGTAAGGCCTCTGGACTGGCCTGTCTG GCCCCTGAGAGTGGTGCCCTGGAACACTCCTCTACTCTTACAGAGCCTTGAGAGACCCAGCTGCAGACCATGCCAGACCCACTGAAATGACCAAGACAGG TTCAGGTAGGGGTGTGGGTCAAACCAAGAAGTGGGTGCCCTTGGTAGCAGCCTGGGGTGACCTCTAGAGCTGGAGGCTGTGGGACTCCAGGGGCCCCCGT GTTCAGGACACATCTATTGCAGAGACTCATTTCACAGCCTTTCGTTCTGCTGACCAAATGGCCAGTTTTCTGGTAGGAAGATGGAGGTTTACCGGTTGTT TAGAAACAGAAATAGACTTAATAAAGGTTTAAAGCTGAAGAGGTTGAAGCTAAAAGGAAAAGGTTGTTGTTAATGAATATCAGGCTATTATTTATTGTAT TAGGAAAATATAATATTTACTGTTAGAATTCTTTTATTTAGGGCCTTTTCTGTGCCAGACATTGCTCTCAGTGCTTTGCATGTATTAGCTCACTGAATCT TCACGACAATGTTGAGAAGTTCCCATTATTATTTCTGTTCTTACAAATGTGAAACGGAAGCTCATAGAGGTGAGAAAACTCAACCAGAGTCACCCAGTTG GTGACTGGGAAAGTTAGGATTCAGATCGAAATTGGACTGTCTTTATAACCCATATTTTCCCCCTGTTTTTAGAGCTTCCAAATGTGTCAGAATAGGAAAA CATTGCAATAAATGGCTTGATTTTTTAATGTCATTTTTCCCTCTTATAGTCTTTCTAGCTCCTTTTCAAAAGACGAGAATATCTGATTTTCTGATAATTT AGGTGCTTAAGCATCCAAAATACATGGGACACACAAAAATCCAGGAATCCCCTGTAGCTTATTCCCTCTTTCCCATCGGAACCAGCTCTCATCACACATT TAAAAGATGATTCTGTTTACCCAATGCTGCATATTGAATGTTGTGTAGTTATTCACAGGGAATTCTGTGCAGTGTGCAGAGAGATTCCTAAACGGGAAAA GGACTGGGAATACATCCTCCTTACTGTGACCTCCCCAAAACCTAGTCCAGTGCAAGGTATACAGTGGTGCTCATTAAATACTTGATGAATACAGGAAGCT GTGCATGTGTTCCTACTTTTATTCGAAGCTCTCTTCTTCCAAAGCTACATGAAAATAGAATTTTAACAGTCAAAATTTTATATTAAGTGCCTTAGCAAAA GAGACATTTAATATTTCAAAGAAATGCATATGTATGTATACATATATTTGTGTATGCGTATGCAAGAATTCTTGTATAAAGAGAATTCACTCCATGAATG ATCTCTTCTGTAAGTCAGTGTGAATCATGTTAGATTTTCTGAGAGTGAAAACACCTGCCATCTACAAATTACAAGGCTGGATAACAGCTCACTCCATTTG AAATTCAGTGGAAACCCAAGAGCTAGGTTCTTACTGAATTTGCATCTCAATTTGGGAAACTGAACTTAGCTTTCAAAGATCATAGGAAGTCTGGTTGGAG AAACTAGGGATTATTCTGGCAATGGGTGCAGGAAGGTGGTCAGAATAACCCAGTCGCCATTGGTTTTGAGAAACGGAACTATCTTATGCAGAGCCCGGAG GGCAAGTCTCAGACCCATGGGTTGAAGCCATGGAGAAGGAAATTTGGATCCAATGTAATGAAGCGCTTTCTAAGTCAGAATTTCCCTGCAATGGTGTGGC CTGATTCAATAAAAATTAAGAATAATAAATATAATGGAAAAAAATCTCCACTGATTGAGTGTTTACTTGGTGCCAAGCACTATGCTAAGTTGTTCATTAT TTTATTTAATTGTTACAGCAATTTTGAGTATGCATCTTTCACTATTTTATAAGTGGAAAAGAGAAGTGCCCCCAAAAAGTTAGAGCTCAAACAGCAGCTT ATTCTACCAGCCCCTGCTCTTGCGGAGGCCTCTGGAAAAGACCTGAATGACACCTATTGGAGAATTACATCTACAAGGGGCTTCAAACAGACCAAATAGA TCATCACCTCTGTGGTCCCTTGTTAACTATATGTTCTGAGACAAAGGAAAGCTACCCTAAGGGTTAGTTAACCTTTGCTGAGGAAATTTACATTCATACT TAGAGTGAATTACTCAGGTGTGCTTAGGTGTGCAAAAGGGAAGGAGACCTGAATTCACCAAGTTAAATCTTGCTAAACCTTATCATAAGCATTTTTTGAG CGCTTAGCATACACCAAGCCTTGTGGAAGGTGCTTTCCTGCCATATCTCATTTAATCCTCACAGCAAACCTATAGAATATGGCATTATCATCTGAGTCTC ACAGAAGTTTAGTCGTGTACTCAAGGTCTTACCAGCTAGTGAACAGCAGACCAAGACTGGAAACCCAGGATAGTCTGATACCTGAGCCATCTCTTCTTGT GCTACGCCTAGTTATTCTGTCCCCCAAATCAAAAGGCATGACCTTTATAAGAGGCGCTTTACTGACAATAGCTGCAATTTTAACTTTGAAAATGATTCAG AATTATCAAAGATAGTAGATTCGAATGACATGATTGTCTATAATCTCGCTAGCCTTGTACTGTGTGTGCATAGCAATTACAGGGAAGTAATCTAGCTCCT GACTATTATGTTGAACTATGTCGCTGCTTTTTACAAACTTGTCTTGATCCAAAGCAGTCACAATGATAACCCTGCATATCTGGGAATCATAAGTCAACTA TGTATCCCTGTGTGTGTATATATATGTATGTATGTATCTATTTTCAAACTGTGATTTAATATTTAAATATTCCTACTGCCATTTTTGTGACTGAAAAACT ACACATGAGGAAACGTCTTAGAATTTTCCAATAGAGGAAAAATAACACTTGGGCAATCTGTCATGTTTCACAACAGTTCTCATTTTTCTCATGATTTGTG TAGCGTGGAATGTGTTTGCTCAATGTGAAGGGTTTTCATTGCTCAATTTCTCTGTGTAAGTCTTTTCCTTAAGGTAATAAACCATCAGCAAAGTCACATA CTGGAGTTGGTGGCTTTTCTTGTACAGGCAGTTGTTATGAGACAATGATGGAGCATTGAGCATGTTCAATAAATGTGCAGATGGTGGAAA

WISP1.u.f.1 (forward primer)
WISP1.u.r.4 (reverse primer)
Multiple exon skipping

Frame 0

ISGAPDGPASLGPAPPRGGRILWAARSMPVPLT SRHEVVPALDAGSSDSSSRQHRPGHGPLSSPYDH GLYPSSTGGHLLTPPILQVAM*VPAIPTPLPAG GQPHHRWL*VL*DVRSAAWGQLHGGCHL*PPPG PLL*LQRGPPEVRNRSVCTGGRCGLRPGWGALQQ RPVLPA*LQVQLHVHRRRGGLHTTVPPSAPPAS LVPPPAAREHTWPLL*AVGM*GRRQEATQDRTP *HRSLRCCG*GGGMAQELHSLHKPLEPLLHQLRP GGLHSDLQC*RPVLA*AREPPLQLAAMRCGHPY TH*GREEVSGCVPARGIHELHTCGLHQHTLLST QVLWSLHGQ*VLHPLQV*DYRRVLPVS*WAWLLP PGPMD*CLLL*PEL*ESQ*HLC*LGILP*LLRN CQLGRHKSWVLGTNPMPVKQSALMANNFSPMSL SYPDLDPWPPFLSLTIQMTPDGAAQAHAMSFLLD IIQHLL*RKMPVSSCSGLHPSLIQPFQVTRSPA GSCLNPKKWNQVDF*YH*FLL*MPNHKTLWVHS DE*MEFGTIE*SIIWSLPRGTVMGNSDVSAPKLS *FQICMHLKVIKHLPSELNSCLILIFNGKLYPL TWALLRLSFSSPLHCEGYRLGLSQSEIKFDKHS C*WEKPPVNTPETGKGQPVSEGPIDSHTESAADW QGFGQLARLFLESSPLSCLGFIGIGKASGLACL APESGALEHSSTLTEP*ETQLQTMPDPLK*PRQ VQVGVWVKPRSGCPW*QPGVTSRAGGCGTPGAPV FRTHLLQRLISQPFVLLTKWPVFW*EDGGLPVV *KQK*T**RFKAEEVEAKRKRLLLMNIRLLFIV LGKYNIYC*NSFI*GLFCARHCSQCFACISSLNL HDNVEKFPLLFLFLQM*NGSS*R*ENSTRVTQL VTGKVRIQIEIGLSL*PIFSPCF*SFQMCQNRK TLQ*MA*FFNVIFPSYSLSSSFSKDENI*FSDNL GA*ASKIHGTHKNPGIPCSLFPLSHRNQLSSHI *KMILFTQCCILNVV*LFTGNSVQCAERFLNGK RTGNTSSLL*PPQNLVQCKVYSGAH*ILDEYRKL CMCSYFYSKLSSSKAT*K*NFNSQNFILSALAK ETFNISKKCICMYTYICVCVCKNSCIKRIHSMN DLFCKSV*IMLDFLRVKTPAIYKLQGWITAHSI* NSVETQELGSY*ICISIWETELSFQRS*EVWLE KLGIILAMGAGRWSE*PSRHWF*ETELSYAEPG GQVSDPWVEAMEKEIWIQCNEALSKSEFPCNGVA *FNKN*E**I*WKKISTD*VFTWCQALC*VVHY FI*LLQQF*VCIFHYFISGKEKCPQKVRAQTAA YSTSPCSCGGLWKRPE*HLLENYIYKGLQTDQID HHLCGPLLTICSETKESYPKG*LTFAEEIYIHT *SELLRCA*VCKREGDLNSPS*ILLNLIISIF* ALSIHQALWKVLSCHISFNPHSKPIEYGIII*VS QKFSRVLKVLPASEQQTKTGNPG*SDT*AISSC ATPSYSVPQIKRHDLYKRRFTDNSCNFNFENDS ELSKIVDSNDMIVYNLASLVLCVHSNYREVI*LL TIMLNYVAAFYKLVLIQSSHNDNPAYLGIISQL CIPVCVYICMYVSIFKL*FNI*IFLLPFL*LKN YT*GNVLEFSNRGKITLGQSVMFHNSSHFSHDLC SVECVCSM*RVFIAQFLCVSLFLKVINHQQSHI LELVAFLVQAVVMRQ*WSIEHVQ*MCRWWK

Frame 1

YLVLLMGRPVWAQLPREVVGSSGLLGRCLCH*R PGMRWFLPWTLAAVTAAAASTVLATALSPAPTT MDFTPAPLEDTSSRPQFCKWPCECPPSPPRCPLG VSLITDGCECCKMCAQQLGDNCTEAAICDPHRG LYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYN NGQSFQPNCKYNCTCIDGAVGCTPLCLRVRPPRL WCPHPRRVSIPGHCCEQWVCEDDAKRPRKTAPR DTGAFDAVGEVEAWHRNCIAYTSPWSPCSTSCG LGVSTRISNVNAQCWPEQESRLCNLRPCDVDIHT LIKAGKKCLAVYQPEASMNFTLAGCISTRSYQP KYCGVCMDNRCCIPYKSKTIDVSFQCPDGLGFS RQVLWINACFCNLSCRNPNDIFADLESYPDFSEI AN*AGTNLGSWGLTQCL*SSQPLWPITFHQ*AL VTLIWTLGLHFCL*PFK*RLMVLLRPML*VFSL ISFSIYSKEKCLSLAVLDYTQA*SSLSKSLEVLL DLA*IPRNGIR*TFNITNFFFRCQTTRLFGSIQ MNRWNLEQ*NNLLFGACQEVL*WVILTSAHQNY PDSKYVCTSRSSNICQVS*IVA*F*FLMESCIH* PGHC*G*VSLHPYTVKGTD*VCPSQK*NLINIP VDGKSPQLILQRQGKVSPFQKDQLTLTLNQLLT GRALGSWPGSSLNLLPCPAWGS*ELVRPLDWPVW PLRVVPWNTPLLLQSLERPSCRPCQTH*NDQDR FR*GCGSNQEVGALGSSLG*PLELEAVGLQGPP CSGHIYCRDSFHSLSFC*PNGQFSGRKMEVYRLF RNRNRLNKGLKLKRLKLKGKGCC**ISGYYLLY *ENIIFTVRILLFRAFSVPDIALSALHVLAH*I FTTMLRSSHYYFCSYKCETEAHRGEKTQPESPSW *LGKLGFRSKLDCLYNPYFPPVFRASKCVRIGK HCNKWLDFLMSFFPLIVFLAPFQKTRISDFLII *VLKHPKYMGHTKIQESPVAYSLFPIGTSSHHTF KR*FCLPNAAY*MLCSYSQGILCSVQRDS*TGK GLGIHPPYCDLPKT*SSARYTVVLIKYLMNTGS CACVPTFIRSSLLPKLHENRILTVKILY*VP*QK RHLIFQRNAYVCIHIFVYAYARILV*REFTP*M ISSVSQCESC*IF*E*KHLPSTNYKAG*QLTPF EIQWKPKS*VLTEFASQFGKLNLAFKDHRKSGWR N*GLFWQWVQEGGQNNPVAIGFEKRNYLMQSPE GKSQTHGLKPWRRKFGSNVMKRFLSQNFPAMVW PDSIKIKNNKYNGKKSPLIECLLGAKHYAKLFII LFNCYSNFEYASFTIL*VEKRSAPKKLELKQQL ILPAPALAEASGKDLNDTYWRITSTRGFKQTK* IITSVVPC*LYVLRQRKATLRVS*PLLRKFTFIL RVNYSGVLRCAKGKET*IHQVKSC*TLS*AFFE RLAYTKPCGRCFPAISHLILTANL*NMALSSES HRSLVVYSRSYQLVNSRPRLETQDSLIPEPSLLV LRLVILSPKSKGMTFIRGALLTIAAILTLKMIQ NYQR**IRMT*LSIISLALYCVCIAITGK*SSS *LLC*TMSLLFTNLS*SKAVTMITLHIWES*VNY VSLCVYIYVCMYLFSNCDLIFKYSYCHFCD*KT THEETS*NFPIEEK*HLGNLSCFTTVLIFLMIC VAWNVFAQCEGFSLLNFSV*VFSLR**TISKVTY WSWWLFLYRQLL*DNDGALSMFNKCADGG

Frame 2

IWCS*WAGQSGPSSPERWSDPLGCSVDACATDV QA*GGSCPGRWQQ*QQQPPAPSWPRPSLQPLRP WTLPQLHWRTPPHAPNSASGHVSARHPHPAARW GSASSQMAVSAVRCALSSLGTTARRLPSVTPTGA STVTTAGTARGTQ*ECVHRWSVWAASWMGCATT TASPSSLTASTTARASTARWAAHHCASECAPRV SGAPTRGA*AYLATAVSSGYVRTTPRGHARPHPV TQEPSMLWVRWRHGTGTA*PTQAPGALAPPAAA WGSPLGSPMLTPSAGLSKRAASATCGHAMWTSI HSLRQGRSVWLCTSQRHP*TSHLRAASAHAPINP STVEFAWTIGAASPTSLRLSTCPSSVLMGLASP ARSYGLMPASVT*AVGIPMTSLLTWNPTLTSQK LPTRQAQILGLGD*PNACEAVSPYGQ*LFTNEP* LP*SGPLASISVSNHSNDA*WCCSGPCYEFSP* YHSASTLKKNACL*LFWTTPKPDPAFPSH*KSC WILPKSQEMESGRLLISLISSLDAKPQDSLGPFR *IDGIWNNRIIYYLEPAKRYCNG*F*RQRTKTI LIPNMYAPQGHQTFAK*VE*LLNFDF*WKVVSI NLGIVEVKFLFTPTL*RVQIRFVPVRNKI**TFL LMGKAPS*YSRDRERSARFRRTN*LSH*ISC*L AGLWAVGQALP*IFSLVLLGVHRNW*GLWTGLS GP*EWCPGTLLYSYRALRDPAADHARPTEMTKTG SGRGVGQTKKWVPLVAAWGDL*SWRLWDSRGPR VQDTSIAETHFTAFRSADQMASFLVGRWRFTGC LETEIDLIKV*S*RG*S*KEKVVVNEYQAIIYCI RKI*YLLLEFFYLGPFLCQTLLSVLCMY*LTES SRQC*EVPIIISVLTNVKRKLIEVRKLNQSHPV GDWES*DSDRNWTVFITHIFPLFLELPNVSE*EN IAINGLIF*CHFSLL*SF*LLFKRREYLIF**F RCLSIQNTWDTQKSRNPL*LIPSFPSEPALITH LKDDSVYPMLHIECCVVIHREFCAVCREIPKREK DWEYILLTVTSPKPSPVQGIQWCSLNT**IQEA VHVFLLLFEALFFQSYMKIEF*QSKFYIKCLSK RDI*YFKEMHMYVYIYLCMRMQEFLYKENSLHE* SLL*VSVNHVRFSESENTCHLQITRLDNSSLHL KFSGNPRARFLLNLHLNLGN*T*LSKIIGSLVG ETRDYSGNGCRKVVRITQSPLVLRNGTILCRARR ASLRPMG*SHGEGNLDPM**SAF*VRISLQWCG LIQ*KLRIINIMEKNLH*LSVYLVPSTMLSCSL FYLIVTAILSMHLSLFYKWKREVPPKS*SSNSSL FYQPLLLRRPLEKT*MTPIGELHLQGASNRPNR SSPLWSLVNYMF*DKGKLP*GLVNLC*GNLHSY LE*ITQVCLGVQKGRRPEFTKLNLAKPYHKHFLS A*HTPSLVEGAFLPYLI*SSQQTYRIWHYHLSL TEV*SCTQGLTS**TADQDWKPRIV*YLSHLFL CYA*LFCPPNQKA*PL*EALY*Q*LQF*L*K*FR IIKDSRFE*HDCL*SR*PCTVCA*QLQGSNLAP DYYVELCRCFLQTCLDPKQSQ**PCISGNHKST MYPCVCIYMYVCIYFQTVI*YLNIPTAIFVTEKL HMRKRLRIFQ*RKNNTWAICHVSQQFSFFS*FV *RGMCLLNVKGFHCSISLCKSFP*GNKPSAKSH TGVGGFSCTGSCYETMMEH*ACSINVQMVE