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Sequence WISP1.cAug05
ATATCTGGTGCTCCTGATGGGCCGGCCAGTCTGGGCCCAGCTCCCCCGAGAGGTGGTCGGATCCTCTGGGCTGCTCGGTCGATGCCTGTGCCACTGACGTCCAGGCATGAGGTGGTTCCTGCCCTGGACGCTGGCAGCAGTGACAGCAGCAGCCGCCAGCACCGTCCTGGCCACGATGCTGTGGGTGAGGTGGAGGCATG
GCACAGGAACTGCATAGCCTACACAAGCCCCTGGAGCCCTTGCTCCACCAGCTGCGGCCTGGGGGTCTCCACTCGGATCTCCAATGTTAACGCCCAGTGC
TGGCCTGAGCAAGAGAGCCGCCTCTGCAACTTGCGGCCATGCGATGTGGACATCCATACACTCATTAAGGCAGGGAAGAAGTGTCTGGCTGTGTACCAGC
CAGAGGCATCCATGAACTTCACACTTGCGGGCTGCATCAGCACACGCTCCTATCAACCCAAGTACTGTGGAGTTTGCATGGACAATAGGTGCTGCATCCC
CTACAAGTCTAAGACTATCGACGTGTCCTTCCAGTGTCCTGATGGGCTTGGCTTCTCCCGCCAGGTCCTATGGATTAATGCCTGCTTCTGTAACCTGAGC
TGTAGGAATCCCAATGACATCTTTGCTGACTTGGAATCCTACCCTGACTTCTCAGAAATTGCCAACTAGGCAGGCACAAATCTTGGGTCTTGGGGACTAA
CCCAATGCCTGTGAAGCAGTCAGCCCTTATGGCCAATAACTTTTCACCAATGAGCCTTAGTTACCCTGATCTGGACCCTTGGCCTCCATTTCTGTCTCTA
ACCATTCAAATGACGCCTGATGGTGCTGCTCAGGCCCATGCTATGAGTTTTCTCCTTGATATCATTCAGCATCTACTCTAAAGAAAAATGCCTGTCTCTA
GCTGTTCTGGACTACACCCAAGCCTGATCCAGCCTTTCCAAGTCACTAGAAGTCCTGCTGGATCTTGCCTAAATCCCAAGAAATGGAATCAGGTAGACTT
TTAATATCACTAATTTCTTCTTTAGATGCCAAACCACAAGACTCTTTGGGTCCATTCAGATGAATAGATGGAATTTGGAACAATAGAATAATCTATTATT
TGGAGCCTGCCAAGAGGTACTGTAATGGGTAATTCTGACGTCAGCGCACCAAAACTATCCTGATTCCAAATATGTATGCACCTCAAGGTCATCAAACATT
TGCCAAGTGAGTTGAATAGTTGCTTAATTTTGATTTTTAATGGAAAGTTGTATCCATTAACCTGGGCATTGTTGAGGTTAAGTTTCTCTTCACCCCTACA
CTGTGAAGGGTACAGATTAGGTTTGTCCCAGTCAGAAATAAAATTTGATAAACATTCCTGTTGATGGGAAAAGCCCCCAGTTAATACTCCAGAGACAGGG
AAAGGTCAGCCCGTTTCAGAAGGACCAATTGACTCTCACACTGAATCAGCTGCTGACTGGCAGGGCTTTGGGCAGTTGGCCAGGCTCTTCCTTGAATCTT
CTCCCTTGTCCTGCTTGGGGTTCATAGGAATTGGTAAGGCCTCTGGACTGGCCTGTCTGGCCCCTGAGAGTGGTGCCCTGGAACACTCCTCTACTCTTAC
AGAGCCTTGAGAGACCCAGCTGCAGACCATGCCAGACCCACTGAAATGACCAAGACAGGTTCAGGTAGGGGTGTGGGTCAAACCAAGAAGTGGGTGCCCT
TGGTAGCAGCCTGGGGTGACCTCTAGAGCTGGAGGCTGTGGGACTCCAGGGGCCCCCGTGTTCAGGACACATCTATTGCAGAGACTCATTTCACAGCCTT
TCGTTCTGCTGACCAAATGGCCAGTTTTCTGGTAGGAAGATGGAGGTTTACCGGTTGTTTAGAAACAGAAATAGACTTAATAAAGGTTTAAAGCTGAAGA
GGTTGAAGCTAAAAGGAAAAGGTTGTTGTTAATGAATATCAGGCTATTATTTATTGTATTAGGAAAATATAATATTTACTGTTAGAATTCTTTTATTTAG
GGCCTTTTCTGTGCCAGACATTGCTCTCAGTGCTTTGCATGTATTAGCTCACTGAATCTTCACGACAATGTTGAGAAGTTCCCATTATTATTTCTGTTCT
TACAAATGTGAAACGGAAGCTCATAGAGGTGAGAAAACTCAACCAGAGTCACCCAGTTGGTGACTGGGAAAGTTAGGATTCAGATCGAAATTGGACTGTC
TTTATAACCCATATTTTCCCCCTGTTTTTAGAGCTTCCAAATGTGTCAGAATAGGAAAACATTGCAATAAATGGCTTGATTTTTTAATGTCATTTTTCCC
TCTTATAGTCTTTCTAGCTCCTTTTCAAAAGACGAGAATATCTGATTTTCTGATAATTTAGGTGCTTAAGCATCCAAAATACATGGGACACACAAAAATC
CAGGAATCCCCTGTAGCTTATTCCCTCTTTCCCATCGGAACCAGCTCTCATCACACATTTAAAAGATGATTCTGTTTACCCAATGCTGCATATTGAATGT
TGTGTAGTTATTCACAGGGAATTCTGTGCAGTGTGCAGAGAGATTCCTAAACGGGAAAAGGACTGGGAATACATCCTCCTTACTGTGACCTCCCCAAAAC
CTAGTCCAGTGCAAGGTATACAGTGGTGCTCATTAAATACTTGATGAATACAGGAAGCTGTGCATGTGTTCCTACTTTTATTCGAAGCTCTCTTCTTCCA
AAGCTACATGAAAATAGAATTTTAACAGTCAAAATTTTATATTAAGTGCCTTAGCAAAAGAGACATTTAATATTTCAAAGAAATGCATATGTATGTATAC
ATATATTTGTGTATGCGTATGCAAGAATTCTTGTATAAAGAGAATTCACTCCATGAATGATCTCTTCTGTAAGTCAGTGTGAATCATGTTAGATTTTCTG
AGAGTGAAAACACCTGCCATCTACAAATTACAAGGCTGGATAACAGCTCACTCCATTTGAAATTCAGTGGAAACCCAAGAGCTAGGTTCTTACTGAATTT
GCATCTCAATTTGGGAAACTGAACTTAGCTTTCAAAGATCATAGGAAGTCTGGTTGGAGAAACTAGGGATTATTCTGGCAATGGGTGCAGGAAGGTGGTC
AGAATAACCCAGTCGCCATTGGTTTTGAGAAACGGAACTATCTTATGCAGAGCCCGGAGGGCAAGTCTCAGACCCATGGGTTGAAGCCATGGAGAAGGAA
ATTTGGATCCAATGTAATGAAGCGCTTTCTAAGTCAGAATTTCCCTGCAATGGTGTGGCCTGATTCAATAAAAATTAAGAATAATAAATATAATGGAAAA
AAATCTCCACTGATTGAGTGTTTACTTGGTGCCAAGCACTATGCTAAGTTGTTCATTATTTTATTTAATTGTTACAGCAATTTTGAGTATGCATCTTTCA
CTATTTTATAAGTGGAAAAGAGAAGTGCCCCCAAAAAGTTAGAGCTCAAACAGCAGCTTATTCTACCAGCCCCTGCTCTTGCGGAGGCCTCTGGAAAAGA
CCTGAATGACACCTATTGGAGAATTACATCTACAAGGGGCTTCAAACAGACCAAATAGATCATCACCTCTGTGGTCCCTTGTTAACTATATGTTCTGAGA
CAAAGGAAAGCTACCCTAAGGGTTAGTTAACCTTTGCTGAGGAAATTTACATTCATACTTAGAGTGAATTACTCAGGTGTGCTTAGGTGTGCAAAAGGGA
AGGAGACCTGAATTCACCAAGTTAAATCTTGCTAAACCTTATCATAAGCATTTTTTGAGCGCTTAGCATACACCAAGCCTTGTGGAAGGTGCTTTCCTGC
CATATCTCATTTAATCCTCACAGCAAACCTATAGAATATGGCATTATCATCTGAGTCTCACAGAAGTTTAGTCGTGTACTCAAGGTCTTACCAGCTAGTG
AACAGCAGACCAAGACTGGAAACCCAGGATAGTCTGATACCTGAGCCATCTCTTCTTGTGCTACGCCTAGTTATTCTGTCCCCCAAATCAAAAGGCATGA
CCTTTATAAGAGGCGCTTTACTGACAATAGCTGCAATTTTAACTTTGAAAATGATTCAGAATTATCAAAGATAGTAGATTCGAATGACATGATTGTCTAT
AATCTCGCTAGCCTTGTACTGTGTGTGCATAGCAATTACAGGGAAGTAATCTAGCTCCTGACTATTATGTTGAACTATGTCGCTGCTTTTTACAAACTTG
TCTTGATCCAAAGCAGTCACAATGATAACCCTGCATATCTGGGAATCATAAGTCAACTATGTATCCCTGTGTGTGTATATATATGTATGTATGTATCTAT
TTTCAAACTGTGATTTAATATTTAAATATTCCTACTGCCATTTTTGTGACTGAAAAACTACACATGAGGAAACGTCTTAGAATTTTCCAATAGAGGAAAA
ATAACACTTGGGCAATCTGTCATGTTTCACAACAGTTCTCATTTTTCTCATGATTTGTGTAGCGTGGAATGTGTTTGCTCAATGTGAAGGGTTTTCATTG
CTCAATTTCTCTGTGTAAGTCTTTTCCTTAAGGTAATAAACCATCAGCAAAGTCACATACTGGAGTTGGTGGCTTTTCTTGTACAGGCAGTTGTTATGAG
ACAATGATGGAGCATTGAGCATGTTCAATAAATGTGCAGATGGTGGAAA
- WISP1.u.f.1 (forward primer)
- WISP1.u.r.4 (reverse primer)
- Mutually exclusive exon skipping
Frame 0
ISGAPDGPASLGPAPPRGGRILWAARSMPVPLTSRHEVVPALDAGSSDSSSRQHRPGHDAVGEVEAW
HRNCIAYTSPWSPCSTSCGLGVSTRISNVNAQC
WPEQESRLCNLRPCDVDIHTLIKAGKKCLAVYQ
PEASMNFTLAGCISTRSYQPKYCGVCMDNRCCIP
YKSKTIDVSFQCPDGLGFSRQVLWINACFCNLS
CRNPNDIFADLESYPDFSEIAN*AGTNLGSWGL
TQCL*SSQPLWPITFHQ*ALVTLIWTLGLHFCL*
PFK*RLMVLLRPML*VFSLISFSIYSKEKCLSL
AVLDYTQA*SSLSKSLEVLLDLA*IPRNGIR*T
FNITNFFFRCQTTRLFGSIQMNRWNLEQ*NNLLF
GACQEVL*WVILTSAHQNYPDSKYVCTSRSSNI
CQVS*IVA*F*FLMESCIH*PGHC*G*VSLHPY
TVKGTD*VCPSQK*NLINIPVDGKSPQLILQRQG
KVSPFQKDQLTLTLNQLLTGRALGSWPGSSLNL
LPCPAWGS*ELVRPLDWPVWPLRVVPWNTPLLL
QSLERPSCRPCQTH*NDQDRFR*GCGSNQEVGAL
GSSLG*PLELEAVGLQGPPCSGHIYCRDSFHSL
SFC*PNGQFSGRKMEVYRLFRNRNRLNKGLKLK
RLKLKGKGCC**ISGYYLLY*ENIIFTVRILLFR
AFSVPDIALSALHVLAH*IFTTMLRSSHYYFCS
YKCETEAHRGEKTQPESPSW*LGKLGFRSKLDC
LYNPYFPPVFRASKCVRIGKHCNKWLDFLMSFFP
LIVFLAPFQKTRISDFLII*VLKHPKYMGHTKI
QESPVAYSLFPIGTSSHHTFKR*FCLPNAAY*M
LCSYSQGILCSVQRDS*TGKGLGIHPPYCDLPKT
*SSARYTVVLIKYLMNTGSCACVPTFIRSSLLP
KLHENRILTVKILY*VP*QKRHLIFQRNAYVCI
HIFVYAYARILV*REFTP*MISSVSQCESC*IF*
E*KHLPSTNYKAG*QLTPFEIQWKPKS*VLTEF
ASQFGKLNLAFKDHRKSGWRN*GLFWQWVQEGG
QNNPVAIGFEKRNYLMQSPEGKSQTHGLKPWRRK
FGSNVMKRFLSQNFPAMVWPDSIKIKNNKYNGK
KSPLIECLLGAKHYAKLFIILFNCYSNFEYASF
TIL*VEKRSAPKKLELKQQLILPAPALAEASGKD
LNDTYWRITSTRGFKQTK*IITSVVPC*LYVLR
QRKATLRVS*PLLRKFTFILRVNYSGVLRCAKG
KET*IHQVKSC*TLS*AFFERLAYTKPCGRCFPA
ISHLILTANL*NMALSSESHRSLVVYSRSYQLV
NSRPRLETQDSLIPEPSLLVLRLVILSPKSKGM
TFIRGALLTIAAILTLKMIQNYQR**IRMT*LSI
ISLALYCVCIAITGK*SSS*LLC*TMSLLFTNL
S*SKAVTMITLHIWES*VNYVSLCVYIYVCMYL
FSNCDLIFKYSYCHFCD*KTTHEETS*NFPIEEK
*HLGNLSCFTTVLIFLMICVAWNVFAQCEGFSL
LNFSV*VFSLR**TISKVTYWSWWLFLYRQLL*
DNDGALSMFNKCADGG
Frame 1
YLVLLMGRPVWAQLPREVVGSSGLLGRCLCH*RPGMRWFLPWTLAAVTAAAASTVLATMLWVRWRH
GTGTA*PTQAPGALAPPAAAWGSPLGSPMLTPSA
GLSKRAASATCGHAMWTSIHSLRQGRSVWLCTS
QRHP*TSHLRAASAHAPINPSTVEFAWTIGAAS
PTSLRLSTCPSSVLMGLASPARSYGLMPASVT*A
VGIPMTSLLTWNPTLTSQKLPTRQAQILGLGD*
PNACEAVSPYGQ*LFTNEP*LP*SGPLASISVS
NHSNDA*WCCSGPCYEFSP*YHSASTLKKNACL*
LFWTTPKPDPAFPSH*KSCWILPKSQEMESGRL
LISLISSLDAKPQDSLGPFR*IDGIWNNRIIYY
LEPAKRYCNG*F*RQRTKTILIPNMYAPQGHQTF
AK*VE*LLNFDF*WKVVSINLGIVEVKFLFTPT
L*RVQIRFVPVRNKI**TFLLMGKAPS*YSRDR
ERSARFRRTN*LSH*ISC*LAGLWAVGQALP*IF
SLVLLGVHRNW*GLWTGLSGP*EWCPGTLLYSY
RALRDPAADHARPTEMTKTGSGRGVGQTKKWVP
LVAAWGDL*SWRLWDSRGPRVQDTSIAETHFTAF
RSADQMASFLVGRWRFTGCLETEIDLIKV*S*R
G*S*KEKVVVNEYQAIIYCIRKI*YLLLEFFYL
GPFLCQTLLSVLCMY*LTESSRQC*EVPIIISVL
TNVKRKLIEVRKLNQSHPVGDWES*DSDRNWTV
FITHIFPLFLELPNVSE*ENIAINGLIF*CHFS
LL*SF*LLFKRREYLIF**FRCLSIQNTWDTQKS
RNPL*LIPSFPSEPALITHLKDDSVYPMLHIEC
CVVIHREFCAVCREIPKREKDWEYILLTVTSPK
PSPVQGIQWCSLNT**IQEAVHVFLLLFEALFFQ
SYMKIEF*QSKFYIKCLSKRDI*YFKEMHMYVY
IYLCMRMQEFLYKENSLHE*SLL*VSVNHVRFS
ESENTCHLQITRLDNSSLHLKFSGNPRARFLLNL
HLNLGN*T*LSKIIGSLVGETRDYSGNGCRKVV
RITQSPLVLRNGTILCRARRASLRPMG*SHGEG
NLDPM**SAF*VRISLQWCGLIQ*KLRIINIMEK
NLH*LSVYLVPSTMLSCSLFYLIVTAILSMHLS
LFYKWKREVPPKS*SSNSSLFYQPLLLRRPLEK
T*MTPIGELHLQGASNRPNRSSPLWSLVNYMF*D
KGKLP*GLVNLC*GNLHSYLE*ITQVCLGVQKG
RRPEFTKLNLAKPYHKHFLSA*HTPSLVEGAFL
PYLI*SSQQTYRIWHYHLSLTEV*SCTQGLTS**
TADQDWKPRIV*YLSHLFLCYA*LFCPPNQKA*
PL*EALY*Q*LQF*L*K*FRIIKDSRFE*HDCL
*SR*PCTVCA*QLQGSNLAPDYYVELCRCFLQTC
LDPKQSQ**PCISGNHKSTMYPCVCIYMYVCIY
FQTVI*YLNIPTAIFVTEKLHMRKRLRIFQ*RK
NNTWAICHVSQQFSFFS*FV*RGMCLLNVKGFHC
SISLCKSFP*GNKPSAKSHTGVGGFSCTGSCYE
TMMEH*ACSINVQMVE
Frame 2
IWCS*WAGQSGPSSPERWSDPLGCSVDACATDVQA*GGSCPGRWQQ*QQQPPAPSWPRCCG*GGGM
AQELHSLHKPLEPLLHQLRPGGLHSDLQC*RPV
LA*AREPPLQLAAMRCGHPYTH*GREEVSGCVPA
RGIHELHTCGLHQHTLLSTQVLWSLHGQ*VLHP
LQV*DYRRVLPVS*WAWLLPPGPMD*CLLL*PE
L*ESQ*HLC*LGILP*LLRNCQLGRHKSWVLGTN
PMPVKQSALMANNFSPMSLSYPDLDPWPPFLSL
TIQMTPDGAAQAHAMSFLLDIIQHLL*RKMPVS
SCSGLHPSLIQPFQVTRSPAGSCLNPKKWNQVDF
*YH*FLL*MPNHKTLWVHSDE*MEFGTIE*SII
WSLPRGTVMGNSDVSAPKLS*FQICMHLKVIKH
LPSELNSCLILIFNGKLYPLTWALLRLSFSSPLH
CEGYRLGLSQSEIKFDKHSC*WEKPPVNTPETG
KGQPVSEGPIDSHTESAADWQGFGQLARLFLES
SPLSCLGFIGIGKASGLACLAPESGALEHSSTLT
EP*ETQLQTMPDPLK*PRQVQVGVWVKPRSGCP
W*QPGVTSRAGGCGTPGAPVFRTHLLQRLISQP
FVLLTKWPVFW*EDGGLPVV*KQK*T**RFKAEE
VEAKRKRLLLMNIRLLFIVLGKYNIYC*NSFI*
GLFCARHCSQCFACISSLNLHDNVEKFPLLFLF
LQM*NGSS*R*ENSTRVTQLVTGKVRIQIEIGLS
L*PIFSPCF*SFQMCQNRKTLQ*MA*FFNVIFP
SYSLSSSFSKDENI*FSDNLGA*ASKIHGTHKN
PGIPCSLFPLSHRNQLSSHI*KMILFTQCCILNV
V*LFTGNSVQCAERFLNGKRTGNTSSLL*PPQN
LVQCKVYSGAH*ILDEYRKLCMCSYFYSKLSSS
KAT*K*NFNSQNFILSALAKETFNISKKCICMYT
YICVCVCKNSCIKRIHSMNDLFCKSV*IMLDFL
RVKTPAIYKLQGWITAHSI*NSVETQELGSY*I
CISIWETELSFQRS*EVWLEKLGIILAMGAGRWS
E*PSRHWF*ETELSYAEPGGQVSDPWVEAMEKE
IWIQCNEALSKSEFPCNGVA*FNKN*E**I*WK
KISTD*VFTWCQALC*VVHYFI*LLQQF*VCIFH
YFISGKEKCPQKVRAQTAAYSTSPCSCGGLWKR
PE*HLLENYIYKGLQTDQIDHHLCGPLLTICSE
TKESYPKG*LTFAEEIYIHT*SELLRCA*VCKRE
GDLNSPS*ILLNLIISIF*ALSIHQALWKVLSC
HISFNPHSKPIEYGIII*VSQKFSRVLKVLPAS
EQQTKTGNPG*SDT*AISSCATPSYSVPQIKRHD
LYKRRFTDNSCNFNFENDSELSKIVDSNDMIVY
NLASLVLCVHSNYREVI*LLTIMLNYVAAFYKL
VLIQSSHNDNPAYLGIISQLCIPVCVYICMYVSI
FKL*FNI*IFLLPFL*LKNYT*GNVLEFSNRGK
ITLGQSVMFHNSSHFSHDLCSVECVCSM*RVFI
AQFLCVSLFLKVINHQQSHILELVAFLVQAVVMR
Q*WSIEHVQ*MCRWWK
Sequence WISP1.dAug05
ATATCTGGTGCTCCTGATGGGCCGGCCAGTCTGGGCCCAGCTCCCCCGAGAGGTGGTCGGATCCTCTGGGCTGCTCGGTCGATGCCTGTGCCACTGACGTCCAGGCATGAGGTGGTTCCTGCCCTGGACGCTGGCAGCAGTGACAGCAGCAGCCGCCAGCACCGTCCTGGCCACGGCCCTCTCTCCAGCCCCTACGACCA
TGGACTTTACCCCAGCTCCACTGGAGGACACCTCCTCACGCCCCCAATTCTGCAAGTGGCCATGTGAGTGCCCGCCATCCCCACCCCGCTGCCCGCTGGG
GGTCAGCCTCATCACAGATGGCTGTGAGTGCTGTAAGATGTGCGCTCAGCAGCTTGGGGACAACTGCACGGAGGCTGCCATCTGTGACCCCCACCGGGGC
CTCTACTGTGACTACAGCGGGGACCGCCCGAGGTACGCAATAGGAGTGTGTGCACGCAGGGAAGAAGTGTCTGGCTGTGTACCAGCCAGAGGCATCCATG
AACTTCACACTTGCGGGCTGCATCAGCACACGCTCCTATCAACCCAAGTACTGTGGAGTTTGCATGGACAATAGGTGCTGCATCCCCTACAAGTCTAAGA
CTATCGACGTGTCCTTCCAGTGTCCTGATGGGCTTGGCTTCTCCCGCCAGGTCCTATGGATTAATGCCTGCTTCTGTAACCTGAGCTGTAGGAATCCCAA
TGACATCTTTGCTGACTTGGAATCCTACCCTGACTTCTCAGAAATTGCCAACTAGGCAGGCACAAATCTTGGGTCTTGGGGACTAACCCAATGCCTGTGA
AGCAGTCAGCCCTTATGGCCAATAACTTTTCACCAATGAGCCTTAGTTACCCTGATCTGGACCCTTGGCCTCCATTTCTGTCTCTAACCATTCAAATGAC
GCCTGATGGTGCTGCTCAGGCCCATGCTATGAGTTTTCTCCTTGATATCATTCAGCATCTACTCTAAAGAAAAATGCCTGTCTCTAGCTGTTCTGGACTA
CACCCAAGCCTGATCCAGCCTTTCCAAGTCACTAGAAGTCCTGCTGGATCTTGCCTAAATCCCAAGAAATGGAATCAGGTAGACTTTTAATATCACTAAT
TTCTTCTTTAGATGCCAAACCACAAGACTCTTTGGGTCCATTCAGATGAATAGATGGAATTTGGAACAATAGAATAATCTATTATTTGGAGCCTGCCAAG
AGGTACTGTAATGGGTAATTCTGACGTCAGCGCACCAAAACTATCCTGATTCCAAATATGTATGCACCTCAAGGTCATCAAACATTTGCCAAGTGAGTTG
AATAGTTGCTTAATTTTGATTTTTAATGGAAAGTTGTATCCATTAACCTGGGCATTGTTGAGGTTAAGTTTCTCTTCACCCCTACACTGTGAAGGGTACA
GATTAGGTTTGTCCCAGTCAGAAATAAAATTTGATAAACATTCCTGTTGATGGGAAAAGCCCCCAGTTAATACTCCAGAGACAGGGAAAGGTCAGCCCGT
TTCAGAAGGACCAATTGACTCTCACACTGAATCAGCTGCTGACTGGCAGGGCTTTGGGCAGTTGGCCAGGCTCTTCCTTGAATCTTCTCCCTTGTCCTGC
TTGGGGTTCATAGGAATTGGTAAGGCCTCTGGACTGGCCTGTCTGGCCCCTGAGAGTGGTGCCCTGGAACACTCCTCTACTCTTACAGAGCCTTGAGAGA
CCCAGCTGCAGACCATGCCAGACCCACTGAAATGACCAAGACAGGTTCAGGTAGGGGTGTGGGTCAAACCAAGAAGTGGGTGCCCTTGGTAGCAGCCTGG
GGTGACCTCTAGAGCTGGAGGCTGTGGGACTCCAGGGGCCCCCGTGTTCAGGACACATCTATTGCAGAGACTCATTTCACAGCCTTTCGTTCTGCTGACC
AAATGGCCAGTTTTCTGGTAGGAAGATGGAGGTTTACCGGTTGTTTAGAAACAGAAATAGACTTAATAAAGGTTTAAAGCTGAAGAGGTTGAAGCTAAAA
GGAAAAGGTTGTTGTTAATGAATATCAGGCTATTATTTATTGTATTAGGAAAATATAATATTTACTGTTAGAATTCTTTTATTTAGGGCCTTTTCTGTGC
CAGACATTGCTCTCAGTGCTTTGCATGTATTAGCTCACTGAATCTTCACGACAATGTTGAGAAGTTCCCATTATTATTTCTGTTCTTACAAATGTGAAAC
GGAAGCTCATAGAGGTGAGAAAACTCAACCAGAGTCACCCAGTTGGTGACTGGGAAAGTTAGGATTCAGATCGAAATTGGACTGTCTTTATAACCCATAT
TTTCCCCCTGTTTTTAGAGCTTCCAAATGTGTCAGAATAGGAAAACATTGCAATAAATGGCTTGATTTTTTAATGTCATTTTTCCCTCTTATAGTCTTTC
TAGCTCCTTTTCAAAAGACGAGAATATCTGATTTTCTGATAATTTAGGTGCTTAAGCATCCAAAATACATGGGACACACAAAAATCCAGGAATCCCCTGT
AGCTTATTCCCTCTTTCCCATCGGAACCAGCTCTCATCACACATTTAAAAGATGATTCTGTTTACCCAATGCTGCATATTGAATGTTGTGTAGTTATTCA
CAGGGAATTCTGTGCAGTGTGCAGAGAGATTCCTAAACGGGAAAAGGACTGGGAATACATCCTCCTTACTGTGACCTCCCCAAAACCTAGTCCAGTGCAA
GGTATACAGTGGTGCTCATTAAATACTTGATGAATACAGGAAGCTGTGCATGTGTTCCTACTTTTATTCGAAGCTCTCTTCTTCCAAAGCTACATGAAAA
TAGAATTTTAACAGTCAAAATTTTATATTAAGTGCCTTAGCAAAAGAGACATTTAATATTTCAAAGAAATGCATATGTATGTATACATATATTTGTGTAT
GCGTATGCAAGAATTCTTGTATAAAGAGAATTCACTCCATGAATGATCTCTTCTGTAAGTCAGTGTGAATCATGTTAGATTTTCTGAGAGTGAAAACACC
TGCCATCTACAAATTACAAGGCTGGATAACAGCTCACTCCATTTGAAATTCAGTGGAAACCCAAGAGCTAGGTTCTTACTGAATTTGCATCTCAATTTGG
GAAACTGAACTTAGCTTTCAAAGATCATAGGAAGTCTGGTTGGAGAAACTAGGGATTATTCTGGCAATGGGTGCAGGAAGGTGGTCAGAATAACCCAGTC
GCCATTGGTTTTGAGAAACGGAACTATCTTATGCAGAGCCCGGAGGGCAAGTCTCAGACCCATGGGTTGAAGCCATGGAGAAGGAAATTTGGATCCAATG
TAATGAAGCGCTTTCTAAGTCAGAATTTCCCTGCAATGGTGTGGCCTGATTCAATAAAAATTAAGAATAATAAATATAATGGAAAAAAATCTCCACTGAT
TGAGTGTTTACTTGGTGCCAAGCACTATGCTAAGTTGTTCATTATTTTATTTAATTGTTACAGCAATTTTGAGTATGCATCTTTCACTATTTTATAAGTG
GAAAAGAGAAGTGCCCCCAAAAAGTTAGAGCTCAAACAGCAGCTTATTCTACCAGCCCCTGCTCTTGCGGAGGCCTCTGGAAAAGACCTGAATGACACCT
ATTGGAGAATTACATCTACAAGGGGCTTCAAACAGACCAAATAGATCATCACCTCTGTGGTCCCTTGTTAACTATATGTTCTGAGACAAAGGAAAGCTAC
CCTAAGGGTTAGTTAACCTTTGCTGAGGAAATTTACATTCATACTTAGAGTGAATTACTCAGGTGTGCTTAGGTGTGCAAAAGGGAAGGAGACCTGAATT
CACCAAGTTAAATCTTGCTAAACCTTATCATAAGCATTTTTTGAGCGCTTAGCATACACCAAGCCTTGTGGAAGGTGCTTTCCTGCCATATCTCATTTAA
TCCTCACAGCAAACCTATAGAATATGGCATTATCATCTGAGTCTCACAGAAGTTTAGTCGTGTACTCAAGGTCTTACCAGCTAGTGAACAGCAGACCAAG
ACTGGAAACCCAGGATAGTCTGATACCTGAGCCATCTCTTCTTGTGCTACGCCTAGTTATTCTGTCCCCCAAATCAAAAGGCATGACCTTTATAAGAGGC
GCTTTACTGACAATAGCTGCAATTTTAACTTTGAAAATGATTCAGAATTATCAAAGATAGTAGATTCGAATGACATGATTGTCTATAATCTCGCTAGCCT
TGTACTGTGTGTGCATAGCAATTACAGGGAAGTAATCTAGCTCCTGACTATTATGTTGAACTATGTCGCTGCTTTTTACAAACTTGTCTTGATCCAAAGC
AGTCACAATGATAACCCTGCATATCTGGGAATCATAAGTCAACTATGTATCCCTGTGTGTGTATATATATGTATGTATGTATCTATTTTCAAACTGTGAT
TTAATATTTAAATATTCCTACTGCCATTTTTGTGACTGAAAAACTACACATGAGGAAACGTCTTAGAATTTTCCAATAGAGGAAAAATAACACTTGGGCA
ATCTGTCATGTTTCACAACAGTTCTCATTTTTCTCATGATTTGTGTAGCGTGGAATGTGTTTGCTCAATGTGAAGGGTTTTCATTGCTCAATTTCTCTGT
GTAAGTCTTTTCCTTAAGGTAATAAACCATCAGCAAAGTCACATACTGGAGTTGGTGGCTTTTCTTGTACAGGCAGTTGTTATGAGACAATGATGGAGCA
TTGAGCATGTTCAATAAATGTGCAGATGGTGGAAA
- WISP1.u.f.1 (forward primer)
- WISP1.u.r.4 (reverse primer)
- Mutually exclusive exon skipping
Frame 0
ISGAPDGPASLGPAPPRGGRILWAARSMPVPLTSRHEVVPALDAGSSDSSSRQHRPGHGPLSSPYDH
GLYPSSTGGHLLTPPILQVAM*VPAIPTPLPAG
GQPHHRWL*VL*DVRSAAWGQLHGGCHL*PPPG
PLL*LQRGPPEVRNRSVCTQGRSVWLCTSQRHP*
TSHLRAASAHAPINPSTVEFAWTIGAASPTSLR
LSTCPSSVLMGLASPARSYGLMPASVT*AVGIP
MTSLLTWNPTLTSQKLPTRQAQILGLGD*PNACE
AVSPYGQ*LFTNEP*LP*SGPLASISVSNHSND
A*WCCSGPCYEFSP*YHSASTLKKNACL*LFWT
TPKPDPAFPSH*KSCWILPKSQEMESGRLLISLI
SSLDAKPQDSLGPFR*IDGIWNNRIIYYLEPAK
RYCNG*F*RQRTKTILIPNMYAPQGHQTFAK*V
E*LLNFDF*WKVVSINLGIVEVKFLFTPTL*RVQ
IRFVPVRNKI**TFLLMGKAPS*YSRDRERSAR
FRRTN*LSH*ISC*LAGLWAVGQALP*IFSLVL
LGVHRNW*GLWTGLSGP*EWCPGTLLYSYRALRD
PAADHARPTEMTKTGSGRGVGQTKKWVPLVAAW
GDL*SWRLWDSRGPRVQDTSIAETHFTAFRSAD
QMASFLVGRWRFTGCLETEIDLIKV*S*RG*S*K
EKVVVNEYQAIIYCIRKI*YLLLEFFYLGPFLC
QTLLSVLCMY*LTESSRQC*EVPIIISVLTNVK
RKLIEVRKLNQSHPVGDWES*DSDRNWTVFITHI
FPLFLELPNVSE*ENIAINGLIF*CHFSLL*SF
*LLFKRREYLIF**FRCLSIQNTWDTQKSRNPL
*LIPSFPSEPALITHLKDDSVYPMLHIECCVVIH
REFCAVCREIPKREKDWEYILLTVTSPKPSPVQ
GIQWCSLNT**IQEAVHVFLLLFEALFFQSYMK
IEF*QSKFYIKCLSKRDI*YFKEMHMYVYIYLCM
RMQEFLYKENSLHE*SLL*VSVNHVRFSESENT
CHLQITRLDNSSLHLKFSGNPRARFLLNLHLNL
GN*T*LSKIIGSLVGETRDYSGNGCRKVVRITQS
PLVLRNGTILCRARRASLRPMG*SHGEGNLDPM
**SAF*VRISLQWCGLIQ*KLRIINIMEKNLH*
LSVYLVPSTMLSCSLFYLIVTAILSMHLSLFYKW
KREVPPKS*SSNSSLFYQPLLLRRPLEKT*MTP
IGELHLQGASNRPNRSSPLWSLVNYMF*DKGKL
P*GLVNLC*GNLHSYLE*ITQVCLGVQKGRRPEF
TKLNLAKPYHKHFLSA*HTPSLVEGAFLPYLI*
SSQQTYRIWHYHLSLTEV*SCTQGLTS**TADQ
DWKPRIV*YLSHLFLCYA*LFCPPNQKA*PL*EA
LY*Q*LQF*L*K*FRIIKDSRFE*HDCL*SR*P
CTVCA*QLQGSNLAPDYYVELCRCFLQTCLDPK
QSQ**PCISGNHKSTMYPCVCIYMYVCIYFQTVI
*YLNIPTAIFVTEKLHMRKRLRIFQ*RKNNTWA
ICHVSQQFSFFS*FV*RGMCLLNVKGFHCSISL
CKSFP*GNKPSAKSHTGVGGFSCTGSCYETMMEH
*ACSINVQMVE
Frame 1
YLVLLMGRPVWAQLPREVVGSSGLLGRCLCH*RPGMRWFLPWTLAAVTAAAASTVLATALSPAPTT
MDFTPAPLEDTSSRPQFCKWPCECPPSPPRCPLG
VSLITDGCECCKMCAQQLGDNCTEAAICDPHRG
LYCDYSGDRPRYAIGVCARREEVSGCVPARGIH
ELHTCGLHQHTLLSTQVLWSLHGQ*VLHPLQV*D
YRRVLPVS*WAWLLPPGPMD*CLLL*PEL*ESQ
*HLC*LGILP*LLRNCQLGRHKSWVLGTNPMPV
KQSALMANNFSPMSLSYPDLDPWPPFLSLTIQMT
PDGAAQAHAMSFLLDIIQHLL*RKMPVSSCSGL
HPSLIQPFQVTRSPAGSCLNPKKWNQVDF*YH*
FLL*MPNHKTLWVHSDE*MEFGTIE*SIIWSLPR
GTVMGNSDVSAPKLS*FQICMHLKVIKHLPSEL
NSCLILIFNGKLYPLTWALLRLSFSSPLHCEGY
RLGLSQSEIKFDKHSC*WEKPPVNTPETGKGQPV
SEGPIDSHTESAADWQGFGQLARLFLESSPLSC
LGFIGIGKASGLACLAPESGALEHSSTLTEP*E
TQLQTMPDPLK*PRQVQVGVWVKPRSGCPW*QPG
VTSRAGGCGTPGAPVFRTHLLQRLISQPFVLLT
KWPVFW*EDGGLPVV*KQK*T**RFKAEEVEAK
RKRLLLMNIRLLFIVLGKYNIYC*NSFI*GLFCA
RHCSQCFACISSLNLHDNVEKFPLLFLFLQM*N
GSS*R*ENSTRVTQLVTGKVRIQIEIGLSL*PI
FSPCF*SFQMCQNRKTLQ*MA*FFNVIFPSYSLS
SSFSKDENI*FSDNLGA*ASKIHGTHKNPGIPC
SLFPLSHRNQLSSHI*KMILFTQCCILNVV*LF
TGNSVQCAERFLNGKRTGNTSSLL*PPQNLVQCK
VYSGAH*ILDEYRKLCMCSYFYSKLSSSKAT*K
*NFNSQNFILSALAKETFNISKKCICMYTYICV
CVCKNSCIKRIHSMNDLFCKSV*IMLDFLRVKTP
AIYKLQGWITAHSI*NSVETQELGSY*ICISIW
ETELSFQRS*EVWLEKLGIILAMGAGRWSE*PS
RHWF*ETELSYAEPGGQVSDPWVEAMEKEIWIQC
NEALSKSEFPCNGVA*FNKN*E**I*WKKISTD
*VFTWCQALC*VVHYFI*LLQQF*VCIFHYFIS
GKEKCPQKVRAQTAAYSTSPCSCGGLWKRPE*HL
LENYIYKGLQTDQIDHHLCGPLLTICSETKESY
PKG*LTFAEEIYIHT*SELLRCA*VCKREGDLN
SPS*ILLNLIISIF*ALSIHQALWKVLSCHISFN
PHSKPIEYGIII*VSQKFSRVLKVLPASEQQTK
TGNPG*SDT*AISSCATPSYSVPQIKRHDLYKR
RFTDNSCNFNFENDSELSKIVDSNDMIVYNLASL
VLCVHSNYREVI*LLTIMLNYVAAFYKLVLIQS
SHNDNPAYLGIISQLCIPVCVYICMYVSIFKL*
FNI*IFLLPFL*LKNYT*GNVLEFSNRGKITLGQ
SVMFHNSSHFSHDLCSVECVCSM*RVFIAQFLC
VSLFLKVINHQQSHILELVAFLVQAVVMRQ*WS
IEHVQ*MCRWWK
Frame 2
IWCS*WAGQSGPSSPERWSDPLGCSVDACATDVQA*GGSCPGRWQQ*QQQPPAPSWPRPSLQPLRP
WTLPQLHWRTPPHAPNSASGHVSARHPHPAARW
GSASSQMAVSAVRCALSSLGTTARRLPSVTPTGA
STVTTAGTARGTQ*ECVHAGKKCLAVYQPEASM
NFTLAGCISTRSYQPKYCGVCMDNRCCIPYKSK
TIDVSFQCPDGLGFSRQVLWINACFCNLSCRNPN
DIFADLESYPDFSEIAN*AGTNLGSWGLTQCL*
SSQPLWPITFHQ*ALVTLIWTLGLHFCL*PFK*
RLMVLLRPML*VFSLISFSIYSKEKCLSLAVLDY
TQA*SSLSKSLEVLLDLA*IPRNGIR*TFNITN
FFFRCQTTRLFGSIQMNRWNLEQ*NNLLFGACQ
EVL*WVILTSAHQNYPDSKYVCTSRSSNICQVS*
IVA*F*FLMESCIH*PGHC*G*VSLHPYTVKGT
D*VCPSQK*NLINIPVDGKSPQLILQRQGKVSP
FQKDQLTLTLNQLLTGRALGSWPGSSLNLLPCPA
WGS*ELVRPLDWPVWPLRVVPWNTPLLLQSLER
PSCRPCQTH*NDQDRFR*GCGSNQEVGALGSSL
G*PLELEAVGLQGPPCSGHIYCRDSFHSLSFC*P
NGQFSGRKMEVYRLFRNRNRLNKGLKLKRLKLK
GKGCC**ISGYYLLY*ENIIFTVRILLFRAFSV
PDIALSALHVLAH*IFTTMLRSSHYYFCSYKCET
EAHRGEKTQPESPSW*LGKLGFRSKLDCLYNPY
FPPVFRASKCVRIGKHCNKWLDFLMSFFPLIVF
LAPFQKTRISDFLII*VLKHPKYMGHTKIQESPV
AYSLFPIGTSSHHTFKR*FCLPNAAY*MLCSYS
QGILCSVQRDS*TGKGLGIHPPYCDLPKT*SSA
RYTVVLIKYLMNTGSCACVPTFIRSSLLPKLHEN
RILTVKILY*VP*QKRHLIFQRNAYVCIHIFVY
AYARILV*REFTP*MISSVSQCESC*IF*E*KH
LPSTNYKAG*QLTPFEIQWKPKS*VLTEFASQFG
KLNLAFKDHRKSGWRN*GLFWQWVQEGGQNNPV
AIGFEKRNYLMQSPEGKSQTHGLKPWRRKFGSN
VMKRFLSQNFPAMVWPDSIKIKNNKYNGKKSPLI
ECLLGAKHYAKLFIILFNCYSNFEYASFTIL*V
EKRSAPKKLELKQQLILPAPALAEASGKDLNDT
YWRITSTRGFKQTK*IITSVVPC*LYVLRQRKAT
LRVS*PLLRKFTFILRVNYSGVLRCAKGKET*I
HQVKSC*TLS*AFFERLAYTKPCGRCFPAISHL
ILTANL*NMALSSESHRSLVVYSRSYQLVNSRPR
LETQDSLIPEPSLLVLRLVILSPKSKGMTFIRG
ALLTIAAILTLKMIQNYQR**IRMT*LSIISLA
LYCVCIAITGK*SSS*LLC*TMSLLFTNLS*SKA
VTMITLHIWES*VNYVSLCVYIYVCMYLFSNCD
LIFKYSYCHFCD*KTTHEETS*NFPIEEK*HLG
NLSCFTTVLIFLMICVAWNVFAQCEGFSLLNFSV
*VFSLR**TISKVTYWSWWLFLYRQLL*DNDGA
LSMFNKCADGG
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