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Sequences

Sequence WISP1.eAug05

ATATCTGGTGCTCCTGATGGGCCGGCCAGTCTGGGCCCAGCTCCCCCGAGAGGTGGTCGGATCCTCTGGGCTGCTCGGTCGATGCCTGTGCCACTGACGT CCAGGCATGAGGTGGTTCCTGCCCTGGACGCTGGCAGCAGTGACAGCAGCAGCCGCCAGCACCGTCCTGGCCACGGCAGGGAAGAAGTGTCTGGCTGTGT ACCAGCCAGAGGCATCCATGAACTTCACACTTGCGGGCTGCATCAGCACACGCTCCTATCAACCCAAGTACTGTGGAGTTTGCATGGACAATAGGTGCTG CATCCCCTACAAGTCTAAGACTATCGACGTGTCCTTCCAGTGTCCTGATGGGCTTGGCTTCTCCCGCCAGGTCCTATGGATTAATGCCTGCTTCTGTAAC CTGAGCTGTAGGAATCCCAATGACATCTTTGCTGACTTGGAATCCTACCCTGACTTCTCAGAAATTGCCAACTAGGCAGGCACAAATCTTGGGTCTTGGG GACTAACCCAATGCCTGTGAAGCAGTCAGCCCTTATGGCCAATAACTTTTCACCAATGAGCCTTAGTTACCCTGATCTGGACCCTTGGCCTCCATTTCTG TCTCTAACCATTCAAATGACGCCTGATGGTGCTGCTCAGGCCCATGCTATGAGTTTTCTCCTTGATATCATTCAGCATCTACTCTAAAGAAAAATGCCTG TCTCTAGCTGTTCTGGACTACACCCAAGCCTGATCCAGCCTTTCCAAGTCACTAGAAGTCCTGCTGGATCTTGCCTAAATCCCAAGAAATGGAATCAGGT AGACTTTTAATATCACTAATTTCTTCTTTAGATGCCAAACCACAAGACTCTTTGGGTCCATTCAGATGAATAGATGGAATTTGGAACAATAGAATAATCT ATTATTTGGAGCCTGCCAAGAGGTACTGTAATGGGTAATTCTGACGTCAGCGCACCAAAACTATCCTGATTCCAAATATGTATGCACCTCAAGGTCATCA AACATTTGCCAAGTGAGTTGAATAGTTGCTTAATTTTGATTTTTAATGGAAAGTTGTATCCATTAACCTGGGCATTGTTGAGGTTAAGTTTCTCTTCACC CCTACACTGTGAAGGGTACAGATTAGGTTTGTCCCAGTCAGAAATAAAATTTGATAAACATTCCTGTTGATGGGAAAAGCCCCCAGTTAATACTCCAGAG ACAGGGAAAGGTCAGCCCGTTTCAGAAGGACCAATTGACTCTCACACTGAATCAGCTGCTGACTGGCAGGGCTTTGGGCAGTTGGCCAGGCTCTTCCTTG AATCTTCTCCCTTGTCCTGCTTGGGGTTCATAGGAATTGGTAAGGCCTCTGGACTGGCCTGTCTGGCCCCTGAGAGTGGTGCCCTGGAACACTCCTCTAC TCTTACAGAGCCTTGAGAGACCCAGCTGCAGACCATGCCAGACCCACTGAAATGACCAAGACAGGTTCAGGTAGGGGTGTGGGTCAAACCAAGAAGTGGG TGCCCTTGGTAGCAGCCTGGGGTGACCTCTAGAGCTGGAGGCTGTGGGACTCCAGGGGCCCCCGTGTTCAGGACACATCTATTGCAGAGACTCATTTCAC AGCCTTTCGTTCTGCTGACCAAATGGCCAGTTTTCTGGTAGGAAGATGGAGGTTTACCGGTTGTTTAGAAACAGAAATAGACTTAATAAAGGTTTAAAGC TGAAGAGGTTGAAGCTAAAAGGAAAAGGTTGTTGTTAATGAATATCAGGCTATTATTTATTGTATTAGGAAAATATAATATTTACTGTTAGAATTCTTTT ATTTAGGGCCTTTTCTGTGCCAGACATTGCTCTCAGTGCTTTGCATGTATTAGCTCACTGAATCTTCACGACAATGTTGAGAAGTTCCCATTATTATTTC TGTTCTTACAAATGTGAAACGGAAGCTCATAGAGGTGAGAAAACTCAACCAGAGTCACCCAGTTGGTGACTGGGAAAGTTAGGATTCAGATCGAAATTGG ACTGTCTTTATAACCCATATTTTCCCCCTGTTTTTAGAGCTTCCAAATGTGTCAGAATAGGAAAACATTGCAATAAATGGCTTGATTTTTTAATGTCATT TTTCCCTCTTATAGTCTTTCTAGCTCCTTTTCAAAAGACGAGAATATCTGATTTTCTGATAATTTAGGTGCTTAAGCATCCAAAATACATGGGACACACA AAAATCCAGGAATCCCCTGTAGCTTATTCCCTCTTTCCCATCGGAACCAGCTCTCATCACACATTTAAAAGATGATTCTGTTTACCCAATGCTGCATATT GAATGTTGTGTAGTTATTCACAGGGAATTCTGTGCAGTGTGCAGAGAGATTCCTAAACGGGAAAAGGACTGGGAATACATCCTCCTTACTGTGACCTCCC CAAAACCTAGTCCAGTGCAAGGTATACAGTGGTGCTCATTAAATACTTGATGAATACAGGAAGCTGTGCATGTGTTCCTACTTTTATTCGAAGCTCTCTT CTTCCAAAGCTACATGAAAATAGAATTTTAACAGTCAAAATTTTATATTAAGTGCCTTAGCAAAAGAGACATTTAATATTTCAAAGAAATGCATATGTAT GTATACATATATTTGTGTATGCGTATGCAAGAATTCTTGTATAAAGAGAATTCACTCCATGAATGATCTCTTCTGTAAGTCAGTGTGAATCATGTTAGAT TTTCTGAGAGTGAAAACACCTGCCATCTACAAATTACAAGGCTGGATAACAGCTCACTCCATTTGAAATTCAGTGGAAACCCAAGAGCTAGGTTCTTACT GAATTTGCATCTCAATTTGGGAAACTGAACTTAGCTTTCAAAGATCATAGGAAGTCTGGTTGGAGAAACTAGGGATTATTCTGGCAATGGGTGCAGGAAG GTGGTCAGAATAACCCAGTCGCCATTGGTTTTGAGAAACGGAACTATCTTATGCAGAGCCCGGAGGGCAAGTCTCAGACCCATGGGTTGAAGCCATGGAG AAGGAAATTTGGATCCAATGTAATGAAGCGCTTTCTAAGTCAGAATTTCCCTGCAATGGTGTGGCCTGATTCAATAAAAATTAAGAATAATAAATATAAT GGAAAAAAATCTCCACTGATTGAGTGTTTACTTGGTGCCAAGCACTATGCTAAGTTGTTCATTATTTTATTTAATTGTTACAGCAATTTTGAGTATGCAT CTTTCACTATTTTATAAGTGGAAAAGAGAAGTGCCCCCAAAAAGTTAGAGCTCAAACAGCAGCTTATTCTACCAGCCCCTGCTCTTGCGGAGGCCTCTGG AAAAGACCTGAATGACACCTATTGGAGAATTACATCTACAAGGGGCTTCAAACAGACCAAATAGATCATCACCTCTGTGGTCCCTTGTTAACTATATGTT CTGAGACAAAGGAAAGCTACCCTAAGGGTTAGTTAACCTTTGCTGAGGAAATTTACATTCATACTTAGAGTGAATTACTCAGGTGTGCTTAGGTGTGCAA AAGGGAAGGAGACCTGAATTCACCAAGTTAAATCTTGCTAAACCTTATCATAAGCATTTTTTGAGCGCTTAGCATACACCAAGCCTTGTGGAAGGTGCTT TCCTGCCATATCTCATTTAATCCTCACAGCAAACCTATAGAATATGGCATTATCATCTGAGTCTCACAGAAGTTTAGTCGTGTACTCAAGGTCTTACCAG CTAGTGAACAGCAGACCAAGACTGGAAACCCAGGATAGTCTGATACCTGAGCCATCTCTTCTTGTGCTACGCCTAGTTATTCTGTCCCCCAAATCAAAAG GCATGACCTTTATAAGAGGCGCTTTACTGACAATAGCTGCAATTTTAACTTTGAAAATGATTCAGAATTATCAAAGATAGTAGATTCGAATGACATGATT GTCTATAATCTCGCTAGCCTTGTACTGTGTGTGCATAGCAATTACAGGGAAGTAATCTAGCTCCTGACTATTATGTTGAACTATGTCGCTGCTTTTTACA AACTTGTCTTGATCCAAAGCAGTCACAATGATAACCCTGCATATCTGGGAATCATAAGTCAACTATGTATCCCTGTGTGTGTATATATATGTATGTATGT ATCTATTTTCAAACTGTGATTTAATATTTAAATATTCCTACTGCCATTTTTGTGACTGAAAAACTACACATGAGGAAACGTCTTAGAATTTTCCAATAGA GGAAAAATAACACTTGGGCAATCTGTCATGTTTCACAACAGTTCTCATTTTTCTCATGATTTGTGTAGCGTGGAATGTGTTTGCTCAATGTGAAGGGTTT TCATTGCTCAATTTCTCTGTGTAAGTCTTTTCCTTAAGGTAATAAACCATCAGCAAAGTCACATACTGGAGTTGGTGGCTTTTCTTGTACAGGCAGTTGT TATGAGACAATGATGGAGCATTGAGCATGTTCAATAAATGTGCAGATGGTGGAAA

WISP1.u.f.1 (forward primer)
WISP1.u.r.4 (reverse primer)
Multiple exon skipping

Frame 0

ISGAPDGPASLGPAPPRGGRILWAARSMPVPLT SRHEVVPALDAGSSDSSSRQHRPGHGREEVSGCV PARGIHELHTCGLHQHTLLSTQVLWSLHGQ*VL HPLQV*DYRRVLPVS*WAWLLPPGPMD*CLLL* PEL*ESQ*HLC*LGILP*LLRNCQLGRHKSWVLG TNPMPVKQSALMANNFSPMSLSYPDLDPWPPFL SLTIQMTPDGAAQAHAMSFLLDIIQHLL*RKMP VSSCSGLHPSLIQPFQVTRSPAGSCLNPKKWNQV DF*YH*FLL*MPNHKTLWVHSDE*MEFGTIE*S IIWSLPRGTVMGNSDVSAPKLS*FQICMHLKVI KHLPSELNSCLILIFNGKLYPLTWALLRLSFSSP LHCEGYRLGLSQSEIKFDKHSC*WEKPPVNTPE TGKGQPVSEGPIDSHTESAADWQGFGQLARLFL ESSPLSCLGFIGIGKASGLACLAPESGALEHSST LTEP*ETQLQTMPDPLK*PRQVQVGVWVKPRSG CPW*QPGVTSRAGGCGTPGAPVFRTHLLQRLIS QPFVLLTKWPVFW*EDGGLPVV*KQK*T**RFKA EEVEAKRKRLLLMNIRLLFIVLGKYNIYC*NSF I*GLFCARHCSQCFACISSLNLHDNVEKFPLLF LFLQM*NGSS*R*ENSTRVTQLVTGKVRIQIEIG LSL*PIFSPCF*SFQMCQNRKTLQ*MA*FFNVI FPSYSLSSSFSKDENI*FSDNLGA*ASKIHGTH KNPGIPCSLFPLSHRNQLSSHI*KMILFTQCCIL NVV*LFTGNSVQCAERFLNGKRTGNTSSLL*PP QNLVQCKVYSGAH*ILDEYRKLCMCSYFYSKLS SSKAT*K*NFNSQNFILSALAKETFNISKKCICM YTYICVCVCKNSCIKRIHSMNDLFCKSV*IMLD FLRVKTPAIYKLQGWITAHSI*NSVETQELGSY *ICISIWETELSFQRS*EVWLEKLGIILAMGAGR WSE*PSRHWF*ETELSYAEPGGQVSDPWVEAME KEIWIQCNEALSKSEFPCNGVA*FNKN*E**I* WKKISTD*VFTWCQALC*VVHYFI*LLQQF*VCI FHYFISGKEKCPQKVRAQTAAYSTSPCSCGGLW KRPE*HLLENYIYKGLQTDQIDHHLCGPLLTIC SETKESYPKG*LTFAEEIYIHT*SELLRCA*VCK REGDLNSPS*ILLNLIISIF*ALSIHQALWKVL SCHISFNPHSKPIEYGIII*VSQKFSRVLKVLP ASEQQTKTGNPG*SDT*AISSCATPSYSVPQIKR HDLYKRRFTDNSCNFNFENDSELSKIVDSNDMI VYNLASLVLCVHSNYREVI*LLTIMLNYVAAFY KLVLIQSSHNDNPAYLGIISQLCIPVCVYICMYV SIFKL*FNI*IFLLPFL*LKNYT*GNVLEFSNR GKITLGQSVMFHNSSHFSHDLCSVECVCSM*RV FIAQFLCVSLFLKVINHQQSHILELVAFLVQAVV MRQ*WSIEHVQ*MCRWWK

Frame 1

YLVLLMGRPVWAQLPREVVGSSGLLGRCLCH*R PGMRWFLPWTLAAVTAAAASTVLATAGKKCLAV YQPEASMNFTLAGCISTRSYQPKYCGVCMDNRCC IPYKSKTIDVSFQCPDGLGFSRQVLWINACFCN LSCRNPNDIFADLESYPDFSEIAN*AGTNLGSW GLTQCL*SSQPLWPITFHQ*ALVTLIWTLGLHFC L*PFK*RLMVLLRPML*VFSLISFSIYSKEKCL SLAVLDYTQA*SSLSKSLEVLLDLA*IPRNGIR *TFNITNFFFRCQTTRLFGSIQMNRWNLEQ*NNL LFGACQEVL*WVILTSAHQNYPDSKYVCTSRSS NICQVS*IVA*F*FLMESCIH*PGHC*G*VSLH PYTVKGTD*VCPSQK*NLINIPVDGKSPQLILQR QGKVSPFQKDQLTLTLNQLLTGRALGSWPGSSL NLLPCPAWGS*ELVRPLDWPVWPLRVVPWNTPL LLQSLERPSCRPCQTH*NDQDRFR*GCGSNQEVG ALGSSLG*PLELEAVGLQGPPCSGHIYCRDSFH SLSFC*PNGQFSGRKMEVYRLFRNRNRLNKGLK LKRLKLKGKGCC**ISGYYLLY*ENIIFTVRILL FRAFSVPDIALSALHVLAH*IFTTMLRSSHYYF CSYKCETEAHRGEKTQPESPSW*LGKLGFRSKL DCLYNPYFPPVFRASKCVRIGKHCNKWLDFLMSF FPLIVFLAPFQKTRISDFLII*VLKHPKYMGHT KIQESPVAYSLFPIGTSSHHTFKR*FCLPNAAY *MLCSYSQGILCSVQRDS*TGKGLGIHPPYCDLP KT*SSARYTVVLIKYLMNTGSCACVPTFIRSSL LPKLHENRILTVKILY*VP*QKRHLIFQRNAYV CIHIFVYAYARILV*REFTP*MISSVSQCESC*I F*E*KHLPSTNYKAG*QLTPFEIQWKPKS*VLT EFASQFGKLNLAFKDHRKSGWRN*GLFWQWVQE GGQNNPVAIGFEKRNYLMQSPEGKSQTHGLKPWR RKFGSNVMKRFLSQNFPAMVWPDSIKIKNNKYN GKKSPLIECLLGAKHYAKLFIILFNCYSNFEYA SFTIL*VEKRSAPKKLELKQQLILPAPALAEASG KDLNDTYWRITSTRGFKQTK*IITSVVPC*LYV LRQRKATLRVS*PLLRKFTFILRVNYSGVLRCA KGKET*IHQVKSC*TLS*AFFERLAYTKPCGRCF PAISHLILTANL*NMALSSESHRSLVVYSRSYQ LVNSRPRLETQDSLIPEPSLLVLRLVILSPKSK GMTFIRGALLTIAAILTLKMIQNYQR**IRMT*L SIISLALYCVCIAITGK*SSS*LLC*TMSLLFT NLS*SKAVTMITLHIWES*VNYVSLCVYIYVCM YLFSNCDLIFKYSYCHFCD*KTTHEETS*NFPIE EK*HLGNLSCFTTVLIFLMICVAWNVFAQCEGF SLLNFSV*VFSLR**TISKVTYWSWWLFLYRQL L*DNDGALSMFNKCADGG

Frame 2

IWCS*WAGQSGPSSPERWSDPLGCSVDACATDV QA*GGSCPGRWQQ*QQQPPAPSWPRQGRSVWLC TSQRHP*TSHLRAASAHAPINPSTVEFAWTIGA ASPTSLRLSTCPSSVLMGLASPARSYGLMPASVT *AVGIPMTSLLTWNPTLTSQKLPTRQAQILGLG D*PNACEAVSPYGQ*LFTNEP*LP*SGPLASIS VSNHSNDA*WCCSGPCYEFSP*YHSASTLKKNAC L*LFWTTPKPDPAFPSH*KSCWILPKSQEMESG RLLISLISSLDAKPQDSLGPFR*IDGIWNNRII YYLEPAKRYCNG*F*RQRTKTILIPNMYAPQGHQ TFAK*VE*LLNFDF*WKVVSINLGIVEVKFLFT PTL*RVQIRFVPVRNKI**TFLLMGKAPS*YSR DRERSARFRRTN*LSH*ISC*LAGLWAVGQALP* IFSLVLLGVHRNW*GLWTGLSGP*EWCPGTLLY SYRALRDPAADHARPTEMTKTGSGRGVGQTKKW VPLVAAWGDL*SWRLWDSRGPRVQDTSIAETHFT AFRSADQMASFLVGRWRFTGCLETEIDLIKV*S *RG*S*KEKVVVNEYQAIIYCIRKI*YLLLEFF YLGPFLCQTLLSVLCMY*LTESSRQC*EVPIIIS VLTNVKRKLIEVRKLNQSHPVGDWES*DSDRNW TVFITHIFPLFLELPNVSE*ENIAINGLIF*CH FSLL*SF*LLFKRREYLIF**FRCLSIQNTWDTQ KSRNPL*LIPSFPSEPALITHLKDDSVYPMLHI ECCVVIHREFCAVCREIPKREKDWEYILLTVTS PKPSPVQGIQWCSLNT**IQEAVHVFLLLFEALF FQSYMKIEF*QSKFYIKCLSKRDI*YFKEMHMY VYIYLCMRMQEFLYKENSLHE*SLL*VSVNHVR FSESENTCHLQITRLDNSSLHLKFSGNPRARFLL NLHLNLGN*T*LSKIIGSLVGETRDYSGNGCRK VVRITQSPLVLRNGTILCRARRASLRPMG*SHG EGNLDPM**SAF*VRISLQWCGLIQ*KLRIINIM EKNLH*LSVYLVPSTMLSCSLFYLIVTAILSMH LSLFYKWKREVPPKS*SSNSSLFYQPLLLRRPL EKT*MTPIGELHLQGASNRPNRSSPLWSLVNYMF *DKGKLP*GLVNLC*GNLHSYLE*ITQVCLGVQ KGRRPEFTKLNLAKPYHKHFLSA*HTPSLVEGA FLPYLI*SSQQTYRIWHYHLSLTEV*SCTQGLTS **TADQDWKPRIV*YLSHLFLCYA*LFCPPNQK A*PL*EALY*Q*LQF*L*K*FRIIKDSRFE*HD CL*SR*PCTVCA*QLQGSNLAPDYYVELCRCFLQ TCLDPKQSQ**PCISGNHKSTMYPCVCIYMYVC IYFQTVI*YLNIPTAIFVTEKLHMRKRLRIFQ* RKNNTWAICHVSQQFSFFS*FV*RGMCLLNVKGF HCSISLCKSFP*GNKPSAKSHTGVGGFSCTGSC YETMMEH*ACSINVQMVE

Sequence WISP1.bAug05

ATATCTGGTGCTCCTGATGGGCCGGCCAGTCTGGGCCCAGCTCCCCCGAGAGGTGGTCGGATCCTCTGGGCTGCTCGGTCGATGCCTGTGCCACTGACGT CCAGGCATGAGGTGGTTCCTGCCCTGGACGCTGGCAGCAGTGACAGCAGCAGCCGCCAGCACCGTCCTGGCCACGGCCCTCTCTCCAGCCCCTACGACCA TGGACTTTACCCCAGCTCCACTGGAGGACACCTCCTCACGCCCCCAATTCTGCAAGTGGCCATGTGAGTGCCCGCCATCCCCACCCCGCTGCCCGCTGGG GGTCAGCCTCATCACAGATGGCTGTGAGTGCTGTAAGATGTGCGCTCAGCAGCTTGGGGACAACTGCACGGAGGCTGCCATCTGTGACCCCCACCGGGGC CTCTACTGTGACTACAGCGGGGACCGCCCGAGGTACGCAATAGGAGTGTGTGCACATGCTGTGGGTGAGGTGGAGGCATGGCACAGGAACTGCATAGCCT ACACAAGCCCCTGGAGCCCTTGCTCCACCAGCTGCGGCCTGGGGGTCTCCACTCGGATCTCCAATGTTAACGCCCAGTGCTGGCCTGAGCAAGAGAGCCG CCTCTGCAACTTGCGGCCATGCGATGTGGACATCCATACACTCATTAAGGCAGGGAAGAAGTGTCTGGCTGTGTACCAGCCAGAGGCATCCATGAACTTC ACACTTGCGGGCTGCATCAGCACACGCTCCTATCAACCCAAGTACTGTGGAGTTTGCATGGACAATAGGTGCTGCATCCCCTACAAGTCTAAGACTATCG ACGTGTCCTTCCAGTGTCCTGATGGGCTTGGCTTCTCCCGCCAGGTCCTATGGATTAATGCCTGCTTCTGTAACCTGAGCTGTAGGAATCCCAATGACAT CTTTGCTGACTTGGAATCCTACCCTGACTTCTCAGAAATTGCCAACTAGGCAGGCACAAATCTTGGGTCTTGGGGACTAACCCAATGCCTGTGAAGCAGT CAGCCCTTATGGCCAATAACTTTTCACCAATGAGCCTTAGTTACCCTGATCTGGACCCTTGGCCTCCATTTCTGTCTCTAACCATTCAAATGACGCCTGA TGGTGCTGCTCAGGCCCATGCTATGAGTTTTCTCCTTGATATCATTCAGCATCTACTCTAAAGAAAAATGCCTGTCTCTAGCTGTTCTGGACTACACCCA AGCCTGATCCAGCCTTTCCAAGTCACTAGAAGTCCTGCTGGATCTTGCCTAAATCCCAAGAAATGGAATCAGGTAGACTTTTAATATCACTAATTTCTTC TTTAGATGCCAAACCACAAGACTCTTTGGGTCCATTCAGATGAATAGATGGAATTTGGAACAATAGAATAATCTATTATTTGGAGCCTGCCAAGAGGTAC TGTAATGGGTAATTCTGACGTCAGCGCACCAAAACTATCCTGATTCCAAATATGTATGCACCTCAAGGTCATCAAACATTTGCCAAGTGAGTTGAATAGT TGCTTAATTTTGATTTTTAATGGAAAGTTGTATCCATTAACCTGGGCATTGTTGAGGTTAAGTTTCTCTTCACCCCTACACTGTGAAGGGTACAGATTAG GTTTGTCCCAGTCAGAAATAAAATTTGATAAACATTCCTGTTGATGGGAAAAGCCCCCAGTTAATACTCCAGAGACAGGGAAAGGTCAGCCCGTTTCAGA AGGACCAATTGACTCTCACACTGAATCAGCTGCTGACTGGCAGGGCTTTGGGCAGTTGGCCAGGCTCTTCCTTGAATCTTCTCCCTTGTCCTGCTTGGGG TTCATAGGAATTGGTAAGGCCTCTGGACTGGCCTGTCTGGCCCCTGAGAGTGGTGCCCTGGAACACTCCTCTACTCTTACAGAGCCTTGAGAGACCCAGC TGCAGACCATGCCAGACCCACTGAAATGACCAAGACAGGTTCAGGTAGGGGTGTGGGTCAAACCAAGAAGTGGGTGCCCTTGGTAGCAGCCTGGGGTGAC CTCTAGAGCTGGAGGCTGTGGGACTCCAGGGGCCCCCGTGTTCAGGACACATCTATTGCAGAGACTCATTTCACAGCCTTTCGTTCTGCTGACCAAATGG CCAGTTTTCTGGTAGGAAGATGGAGGTTTACCGGTTGTTTAGAAACAGAAATAGACTTAATAAAGGTTTAAAGCTGAAGAGGTTGAAGCTAAAAGGAAAA GGTTGTTGTTAATGAATATCAGGCTATTATTTATTGTATTAGGAAAATATAATATTTACTGTTAGAATTCTTTTATTTAGGGCCTTTTCTGTGCCAGACA TTGCTCTCAGTGCTTTGCATGTATTAGCTCACTGAATCTTCACGACAATGTTGAGAAGTTCCCATTATTATTTCTGTTCTTACAAATGTGAAACGGAAGC TCATAGAGGTGAGAAAACTCAACCAGAGTCACCCAGTTGGTGACTGGGAAAGTTAGGATTCAGATCGAAATTGGACTGTCTTTATAACCCATATTTTCCC CCTGTTTTTAGAGCTTCCAAATGTGTCAGAATAGGAAAACATTGCAATAAATGGCTTGATTTTTTAATGTCATTTTTCCCTCTTATAGTCTTTCTAGCTC CTTTTCAAAAGACGAGAATATCTGATTTTCTGATAATTTAGGTGCTTAAGCATCCAAAATACATGGGACACACAAAAATCCAGGAATCCCCTGTAGCTTA TTCCCTCTTTCCCATCGGAACCAGCTCTCATCACACATTTAAAAGATGATTCTGTTTACCCAATGCTGCATATTGAATGTTGTGTAGTTATTCACAGGGA ATTCTGTGCAGTGTGCAGAGAGATTCCTAAACGGGAAAAGGACTGGGAATACATCCTCCTTACTGTGACCTCCCCAAAACCTAGTCCAGTGCAAGGTATA CAGTGGTGCTCATTAAATACTTGATGAATACAGGAAGCTGTGCATGTGTTCCTACTTTTATTCGAAGCTCTCTTCTTCCAAAGCTACATGAAAATAGAAT TTTAACAGTCAAAATTTTATATTAAGTGCCTTAGCAAAAGAGACATTTAATATTTCAAAGAAATGCATATGTATGTATACATATATTTGTGTATGCGTAT GCAAGAATTCTTGTATAAAGAGAATTCACTCCATGAATGATCTCTTCTGTAAGTCAGTGTGAATCATGTTAGATTTTCTGAGAGTGAAAACACCTGCCAT CTACAAATTACAAGGCTGGATAACAGCTCACTCCATTTGAAATTCAGTGGAAACCCAAGAGCTAGGTTCTTACTGAATTTGCATCTCAATTTGGGAAACT GAACTTAGCTTTCAAAGATCATAGGAAGTCTGGTTGGAGAAACTAGGGATTATTCTGGCAATGGGTGCAGGAAGGTGGTCAGAATAACCCAGTCGCCATT GGTTTTGAGAAACGGAACTATCTTATGCAGAGCCCGGAGGGCAAGTCTCAGACCCATGGGTTGAAGCCATGGAGAAGGAAATTTGGATCCAATGTAATGA AGCGCTTTCTAAGTCAGAATTTCCCTGCAATGGTGTGGCCTGATTCAATAAAAATTAAGAATAATAAATATAATGGAAAAAAATCTCCACTGATTGAGTG TTTACTTGGTGCCAAGCACTATGCTAAGTTGTTCATTATTTTATTTAATTGTTACAGCAATTTTGAGTATGCATCTTTCACTATTTTATAAGTGGAAAAG AGAAGTGCCCCCAAAAAGTTAGAGCTCAAACAGCAGCTTATTCTACCAGCCCCTGCTCTTGCGGAGGCCTCTGGAAAAGACCTGAATGACACCTATTGGA GAATTACATCTACAAGGGGCTTCAAACAGACCAAATAGATCATCACCTCTGTGGTCCCTTGTTAACTATATGTTCTGAGACAAAGGAAAGCTACCCTAAG GGTTAGTTAACCTTTGCTGAGGAAATTTACATTCATACTTAGAGTGAATTACTCAGGTGTGCTTAGGTGTGCAAAAGGGAAGGAGACCTGAATTCACCAA GTTAAATCTTGCTAAACCTTATCATAAGCATTTTTTGAGCGCTTAGCATACACCAAGCCTTGTGGAAGGTGCTTTCCTGCCATATCTCATTTAATCCTCA CAGCAAACCTATAGAATATGGCATTATCATCTGAGTCTCACAGAAGTTTAGTCGTGTACTCAAGGTCTTACCAGCTAGTGAACAGCAGACCAAGACTGGA AACCCAGGATAGTCTGATACCTGAGCCATCTCTTCTTGTGCTACGCCTAGTTATTCTGTCCCCCAAATCAAAAGGCATGACCTTTATAAGAGGCGCTTTA CTGACAATAGCTGCAATTTTAACTTTGAAAATGATTCAGAATTATCAAAGATAGTAGATTCGAATGACATGATTGTCTATAATCTCGCTAGCCTTGTACT GTGTGTGCATAGCAATTACAGGGAAGTAATCTAGCTCCTGACTATTATGTTGAACTATGTCGCTGCTTTTTACAAACTTGTCTTGATCCAAAGCAGTCAC AATGATAACCCTGCATATCTGGGAATCATAAGTCAACTATGTATCCCTGTGTGTGTATATATATGTATGTATGTATCTATTTTCAAACTGTGATTTAATA TTTAAATATTCCTACTGCCATTTTTGTGACTGAAAAACTACACATGAGGAAACGTCTTAGAATTTTCCAATAGAGGAAAAATAACACTTGGGCAATCTGT CATGTTTCACAACAGTTCTCATTTTTCTCATGATTTGTGTAGCGTGGAATGTGTTTGCTCAATGTGAAGGGTTTTCATTGCTCAATTTCTCTGTGTAAGT CTTTTCCTTAAGGTAATAAACCATCAGCAAAGTCACATACTGGAGTTGGTGGCTTTTCTTGTACAGGCAGTTGTTATGAGACAATGATGGAGCATTGAGC ATGTTCAATAAATGTGCAGATGGTGGAAA

WISP1.u.f.1 (forward primer)
WISP1.u.r.4 (reverse primer)
Multiple exon skipping

Frame 0

ISGAPDGPASLGPAPPRGGRILWAARSMPVPLT SRHEVVPALDAGSSDSSSRQHRPGHGPLSSPYDH GLYPSSTGGHLLTPPILQVAM*VPAIPTPLPAG GQPHHRWL*VL*DVRSAAWGQLHGGCHL*PPPG PLL*LQRGPPEVRNRSVCTCCG*GGGMAQELHSL HKPLEPLLHQLRPGGLHSDLQC*RPVLA*AREP PLQLAAMRCGHPYTH*GREEVSGCVPARGIHEL HTCGLHQHTLLSTQVLWSLHGQ*VLHPLQV*DYR RVLPVS*WAWLLPPGPMD*CLLL*PEL*ESQ*H LC*LGILP*LLRNCQLGRHKSWVLGTNPMPVKQ SALMANNFSPMSLSYPDLDPWPPFLSLTIQMTPD GAAQAHAMSFLLDIIQHLL*RKMPVSSCSGLHP SLIQPFQVTRSPAGSCLNPKKWNQVDF*YH*FL L*MPNHKTLWVHSDE*MEFGTIE*SIIWSLPRGT VMGNSDVSAPKLS*FQICMHLKVIKHLPSELNS CLILIFNGKLYPLTWALLRLSFSSPLHCEGYRL GLSQSEIKFDKHSC*WEKPPVNTPETGKGQPVSE GPIDSHTESAADWQGFGQLARLFLESSPLSCLG FIGIGKASGLACLAPESGALEHSSTLTEP*ETQ LQTMPDPLK*PRQVQVGVWVKPRSGCPW*QPGVT SRAGGCGTPGAPVFRTHLLQRLISQPFVLLTKW PVFW*EDGGLPVV*KQK*T**RFKAEEVEAKRK RLLLMNIRLLFIVLGKYNIYC*NSFI*GLFCARH CSQCFACISSLNLHDNVEKFPLLFLFLQM*NGS S*R*ENSTRVTQLVTGKVRIQIEIGLSL*PIFS PCF*SFQMCQNRKTLQ*MA*FFNVIFPSYSLSSS FSKDENI*FSDNLGA*ASKIHGTHKNPGIPCSL FPLSHRNQLSSHI*KMILFTQCCILNVV*LFTG NSVQCAERFLNGKRTGNTSSLL*PPQNLVQCKVY SGAH*ILDEYRKLCMCSYFYSKLSSSKAT*K*N FNSQNFILSALAKETFNISKKCICMYTYICVCV CKNSCIKRIHSMNDLFCKSV*IMLDFLRVKTPAI YKLQGWITAHSI*NSVETQELGSY*ICISIWET ELSFQRS*EVWLEKLGIILAMGAGRWSE*PSRH WF*ETELSYAEPGGQVSDPWVEAMEKEIWIQCNE ALSKSEFPCNGVA*FNKN*E**I*WKKISTD*V FTWCQALC*VVHYFI*LLQQF*VCIFHYFISGK EKCPQKVRAQTAAYSTSPCSCGGLWKRPE*HLLE NYIYKGLQTDQIDHHLCGPLLTICSETKESYPK G*LTFAEEIYIHT*SELLRCA*VCKREGDLNSP S*ILLNLIISIF*ALSIHQALWKVLSCHISFNPH SKPIEYGIII*VSQKFSRVLKVLPASEQQTKTG NPG*SDT*AISSCATPSYSVPQIKRHDLYKRRF TDNSCNFNFENDSELSKIVDSNDMIVYNLASLVL CVHSNYREVI*LLTIMLNYVAAFYKLVLIQSSH NDNPAYLGIISQLCIPVCVYICMYVSIFKL*FN I*IFLLPFL*LKNYT*GNVLEFSNRGKITLGQSV MFHNSSHFSHDLCSVECVCSM*RVFIAQFLCVS LFLKVINHQQSHILELVAFLVQAVVMRQ*WSIE HVQ*MCRWWK

Frame 1

YLVLLMGRPVWAQLPREVVGSSGLLGRCLCH*R PGMRWFLPWTLAAVTAAAASTVLATALSPAPTT MDFTPAPLEDTSSRPQFCKWPCECPPSPPRCPLG VSLITDGCECCKMCAQQLGDNCTEAAICDPHRG LYCDYSGDRPRYAIGVCAHAVGEVEAWHRNCIA YTSPWSPCSTSCGLGVSTRISNVNAQCWPEQESR LCNLRPCDVDIHTLIKAGKKCLAVYQPEASMNF TLAGCISTRSYQPKYCGVCMDNRCCIPYKSKTI DVSFQCPDGLGFSRQVLWINACFCNLSCRNPNDI FADLESYPDFSEIAN*AGTNLGSWGLTQCL*SS QPLWPITFHQ*ALVTLIWTLGLHFCL*PFK*RL MVLLRPML*VFSLISFSIYSKEKCLSLAVLDYTQ A*SSLSKSLEVLLDLA*IPRNGIR*TFNITNFF FRCQTTRLFGSIQMNRWNLEQ*NNLLFGACQEV L*WVILTSAHQNYPDSKYVCTSRSSNICQVS*IV A*F*FLMESCIH*PGHC*G*VSLHPYTVKGTD* VCPSQK*NLINIPVDGKSPQLILQRQGKVSPFQ KDQLTLTLNQLLTGRALGSWPGSSLNLLPCPAWG S*ELVRPLDWPVWPLRVVPWNTPLLLQSLERPS CRPCQTH*NDQDRFR*GCGSNQEVGALGSSLG* PLELEAVGLQGPPCSGHIYCRDSFHSLSFC*PNG QFSGRKMEVYRLFRNRNRLNKGLKLKRLKLKGK GCC**ISGYYLLY*ENIIFTVRILLFRAFSVPD IALSALHVLAH*IFTTMLRSSHYYFCSYKCETEA HRGEKTQPESPSW*LGKLGFRSKLDCLYNPYFP PVFRASKCVRIGKHCNKWLDFLMSFFPLIVFLA PFQKTRISDFLII*VLKHPKYMGHTKIQESPVAY SLFPIGTSSHHTFKR*FCLPNAAY*MLCSYSQG ILCSVQRDS*TGKGLGIHPPYCDLPKT*SSARY TVVLIKYLMNTGSCACVPTFIRSSLLPKLHENRI LTVKILY*VP*QKRHLIFQRNAYVCIHIFVYAY ARILV*REFTP*MISSVSQCESC*IF*E*KHLP STNYKAG*QLTPFEIQWKPKS*VLTEFASQFGKL NLAFKDHRKSGWRN*GLFWQWVQEGGQNNPVAI GFEKRNYLMQSPEGKSQTHGLKPWRRKFGSNVM KRFLSQNFPAMVWPDSIKIKNNKYNGKKSPLIEC LLGAKHYAKLFIILFNCYSNFEYASFTIL*VEK RSAPKKLELKQQLILPAPALAEASGKDLNDTYW RITSTRGFKQTK*IITSVVPC*LYVLRQRKATLR VS*PLLRKFTFILRVNYSGVLRCAKGKET*IHQ VKSC*TLS*AFFERLAYTKPCGRCFPAISHLIL TANL*NMALSSESHRSLVVYSRSYQLVNSRPRLE TQDSLIPEPSLLVLRLVILSPKSKGMTFIRGAL LTIAAILTLKMIQNYQR**IRMT*LSIISLALY CVCIAITGK*SSS*LLC*TMSLLFTNLS*SKAVT MITLHIWES*VNYVSLCVYIYVCMYLFSNCDLI FKYSYCHFCD*KTTHEETS*NFPIEEK*HLGNL SCFTTVLIFLMICVAWNVFAQCEGFSLLNFSV*V FSLR**TISKVTYWSWWLFLYRQLL*DNDGALS MFNKCADGG

Frame 2

IWCS*WAGQSGPSSPERWSDPLGCSVDACATDV QA*GGSCPGRWQQ*QQQPPAPSWPRPSLQPLRP WTLPQLHWRTPPHAPNSASGHVSARHPHPAARW GSASSQMAVSAVRCALSSLGTTARRLPSVTPTGA STVTTAGTARGTQ*ECVHMLWVRWRHGTGTA*P TQAPGALAPPAAAWGSPLGSPMLTPSAGLSKRA ASATCGHAMWTSIHSLRQGRSVWLCTSQRHP*TS HLRAASAHAPINPSTVEFAWTIGAASPTSLRLS TCPSSVLMGLASPARSYGLMPASVT*AVGIPMT SLLTWNPTLTSQKLPTRQAQILGLGD*PNACEAV SPYGQ*LFTNEP*LP*SGPLASISVSNHSNDA* WCCSGPCYEFSP*YHSASTLKKNACL*LFWTTP KPDPAFPSH*KSCWILPKSQEMESGRLLISLISS LDAKPQDSLGPFR*IDGIWNNRIIYYLEPAKRY CNG*F*RQRTKTILIPNMYAPQGHQTFAK*VE* LLNFDF*WKVVSINLGIVEVKFLFTPTL*RVQIR FVPVRNKI**TFLLMGKAPS*YSRDRERSARFR RTN*LSH*ISC*LAGLWAVGQALP*IFSLVLLG VHRNW*GLWTGLSGP*EWCPGTLLYSYRALRDPA ADHARPTEMTKTGSGRGVGQTKKWVPLVAAWGD L*SWRLWDSRGPRVQDTSIAETHFTAFRSADQM ASFLVGRWRFTGCLETEIDLIKV*S*RG*S*KEK VVVNEYQAIIYCIRKI*YLLLEFFYLGPFLCQT LLSVLCMY*LTESSRQC*EVPIIISVLTNVKRK LIEVRKLNQSHPVGDWES*DSDRNWTVFITHIFP LFLELPNVSE*ENIAINGLIF*CHFSLL*SF*L LFKRREYLIF**FRCLSIQNTWDTQKSRNPL*L IPSFPSEPALITHLKDDSVYPMLHIECCVVIHRE FCAVCREIPKREKDWEYILLTVTSPKPSPVQGI QWCSLNT**IQEAVHVFLLLFEALFFQSYMKIE F*QSKFYIKCLSKRDI*YFKEMHMYVYIYLCMRM QEFLYKENSLHE*SLL*VSVNHVRFSESENTCH LQITRLDNSSLHLKFSGNPRARFLLNLHLNLGN *T*LSKIIGSLVGETRDYSGNGCRKVVRITQSPL VLRNGTILCRARRASLRPMG*SHGEGNLDPM** SAF*VRISLQWCGLIQ*KLRIINIMEKNLH*LS VYLVPSTMLSCSLFYLIVTAILSMHLSLFYKWKR EVPPKS*SSNSSLFYQPLLLRRPLEKT*MTPIG ELHLQGASNRPNRSSPLWSLVNYMF*DKGKLP* GLVNLC*GNLHSYLE*ITQVCLGVQKGRRPEFTK LNLAKPYHKHFLSA*HTPSLVEGAFLPYLI*SS QQTYRIWHYHLSLTEV*SCTQGLTS**TADQDW KPRIV*YLSHLFLCYA*LFCPPNQKA*PL*EALY *Q*LQF*L*K*FRIIKDSRFE*HDCL*SR*PCT VCA*QLQGSNLAPDYYVELCRCFLQTCLDPKQS Q**PCISGNHKSTMYPCVCIYMYVCIYFQTVI*Y LNIPTAIFVTEKLHMRKRLRIFQ*RKNNTWAIC HVSQQFSFFS*FV*RGMCLLNVKGFHCSISLCK SFP*GNKPSAKSHTGVGGFSCTGSCYETMMEH*A CSINVQMVE