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Sequences

Sequence STAT1.bAug05

GGTGGGGGCGGAAGGGGGCCGGGCGCCAGCGCTGCCTTTTCTCCTGCCGGGTAGTTTCGCTTTCCTGCGCAGAGTCTGCGGAGGGGCTCGGCTGCACCGG GGGGATCGCGCCTGGCAGACCCCAGACCGAGCAGAGGCGACCCAGCGCGCTCGGGAGAGGCTGCACCGCCGCGCCCCCGCCTAGCCCTTCCGGATCCTGC GCGCAGAGATGTCTCAGTGGTACGAACTTCAGCAGCTTGACTCAAAATTCCTGGAGCAGGTTCACCAGCTTTATGATGACAGTTTTCCCATGGAAATCAG ACAGTACCTGGCACAGTGGTTAGAAAAGCAAGACTGGGAGCACGCTGCCAATGATGTTTCATTTGCCACCATCCGTTTTCATGACCTCCTGTCACAGCTG GATGATCAATATAGTCGCTTTTCTTTGGAGAATAACTTCTTGCTACAGCATAACATAAGGAAAAGCAAGCGTAATCTTCAGGATAATTTTCAGGAAGACC CAATCCAGATGTCTATGATCATTTACAGCTGTCTGAAGGAAGAAAGGAAAATTCTGGAAAACGCCCAGAGATTTAATCAGGCTCAGTCGGGGAATATTCA GAGCACAGTGATGTTAGACAAACAGAAAGAGCTTGACAGTAAAGTCAGAAATGTGAAGGACAAGGTTATGTGTATAGAGCATGAAATCAAGAGCCTGGAA GATTTACAAGATGAATATGACTTCAAATGCAAAACCTTGCAGAACAGAGAACACGAGACCAATGGTGTGGCAAAGAGTGATCAGAAACAAGAACAGCTGT TACTCAAGAAGATGTATTTAATGCTTGACAATAAGAGAAAGGAAGTAGTTCACAAAATAATAGAGTTGCTGAATGTCACTGAACTTACCCAGAATGCCCT GATTAATGATGAACTAGTGGAGTGGAAGCGGAGACAGCAGAGCGCCTGTATTGGGGGGCCGCCCAATGCTTGCTTGGATCAGCTGCAGAACTGGTTCACT ATAGTTGCGGAGAGTCTGCAGCAAGTTCGGCAGCAGCTTAAAAAGTTGGAGGAATTGGAACAGAAATACACCTACGAACATGACCCTATCACAAAAAACA AACAAGTGTTATGGGACCGCACCTTCAGTCTTTTCCAGCAGCTCATTCAGAGCTCGTTTGTGGTGGAAAGACAGCCCTGCATGCCAACGCACCCTCAGAG GCCGCTGGTCTTGAAGACAGGGGTCCAGTTCACTGTGAAGTTGAGACTGTTGGTGAAATTGCAAGAGCTGAATTATAATTTGAAAGTCAAAGTCTTATTT GATAAAGATGTGAATGAGAGAAATACAGTAAAAGGATTTAGGAAGTTCAACATTTTGGGCACGCACACAAAAGTGATGAACATGGAGGAGTCCACCAATG GCAGTCTGGCGGCTGAATTTCGGCACCTGCAATTGAAAGAACAGAAAAATGCTGGCACCAGAACGAATGAGGGTCCTCTCATCGTTACTGAAGAGCTTCA CTCCCTTAGTTTTGAAACCCAATTGTGCCAGCCTGGTTTGGTAATTGACCTCGAGACGACCTCTCTGCCCGTTGTGGTGATCTCCAACGTCAGCCAGCTC CCGAGCGGTTGGGCCTCCATCCTTTGGTACAACATGCTGGTGGCGGAACCCAGGAATCTGTCCTTCTTCCTGACTCCACCATGTGCACGATGGGCTCAGC TTTCAGAAGTGCTGAGTTGGCAGTTTTCTTCTGTCACCAAAAGAGGTCTCAATGTGGACCAGCTGAACATGTTGGGAGAGAAGCTTCTTGGTCCTAACGC CAGCCCCGATGGTCTCATTCCGTGGACGAGGTTTTGTAAGGAAAATATAAATGATAAAAATTTTCCCTTCTGGCTTTGGATTGAAAGCATCCTAGAACTC ATTAAAAAACACCTGCTCCCTCTCTGGAATGATGGGTGCATCATGGGCTTCATCAGCAAGGAGCGAGAGCGTGCCCTGTTGAAGGACCAGCAGCCGGGGA CCTTCCTGCTGCGGTTCAGTGAGAGCTCCCGGGAAGGGGCCATCACATTCACATGGGTGGAGCGGTCCCAGAACGGAGGCGAACCTGACTTCCATGCGGT TGAACCCTACACGAAGAAAGAACTTTCTGCTGTTACTTTCCCTGACATCATTCGCAATTACAAAGTCATGGCTGCTGAGAATATTCCTGAGAATCCCCTG AAGTATCTGTATCCAAATATTGACAAAGACCATGCCTTTGGAAAGTATTACTCCAGGCCAAAGGAAGCACCAGAGCCAATGGAACTTGATGGCCCTAAAG GAACTGGATATATCAAGACTGAGTTGATTTCTGTGTCTGAAGTTCACCCTTCTAGACTTCAGACCACAGACAACCTGCTCCCCATGTCTCCTGAGGAGTT TGACGAGGTGTCTCGGATAGTGGGCTCTGTAGAATTCGACAGTATGATGAACACAGTATAGAGCATGAATTTTTTTCATCTTCTCTGGCGACAGTTTTCC TTCTCATCTGTGATTCCCTCCTGCTACTCTGTTCCTTCACATCCTGTGTTTCTAGGGAAATGAAAGAAAGGCCAGCAAATTCGCTGCAACCTGTTGATAG CAAGTGAATTTTTCTCTAACTCAGAAACATCAGTTACTCTGAAGGGCATCATGCATCTTACTGAAGGTAAAATTGAAAGGCATTCTCTGAAGAGTGGGTT TCACAAGTGAAAAACATCCAGATACACCCAAAGTATCAGGACGAGAATGAGGGTCCTTTGGGAAAGGAGAAGTTAAGCAACATCTAGCAAATGTTATGCA TAAAGTCAGTGCCCAACTGTTATAGGTTGTTGGATAAATCAGTGGTTATTTAGGGAACTGCTTGACGTAGGAACGGTAAATTTCTGTGGGAGAATTCTTA CATGTTTTCTTTGCTTTAAGTGTAACTGGCAGTTTTCCATTGGTTTACCTGTGAAATAGTTCAAAGCCAAGTTTATATACAATTATATCAGTCCTCTTTC AAAGGTAGCCATCATGGATCTGGTAGGGGGAAAATGTGTATTTTATTACATCTTTCACATTGGCTATTTAAAGACAAAGACAAATTCTAAGGATGTACAT TTCCAAATTCACAAGTTGTGTTTGATATCCAAAGCTGAATACATTCTGCTTTCATCTTGGTCACATACAATTATTTTTACAGTTCTCCCAAGGGAGTTAG GCTATTCACAACCACTCATTCAAAAGTTGAAATTAACCATAGATGTAGATAAACTCAGAAATTTAATTCATGTTTCTTAAATGGGCTACTTTGTCCTTTT TGTTATTAGGGTGGTATTTAGTCTATTAGCCACAAAATTGGGAAAGGAGTAGAAAAAGCAGTAACTGACAACTTGAATAATACACCAGAGATAATATGAG AATCAGATCATTTCAAAACTCATTTCCTATGTAACTGCATTGAGAACTGCATATGTTTCGCTGATATATGTGTTTTTCACATTTGCGAATGGTTCCATTC TCTCTCCTGTACTTTTTCCAGACACTTTTTTGAGTGGATGATGTTTCGTGAAGTATACTGTATTTTTACCTTTTTCCTTCCTTATCACTGACACAAAAAG TAGATTAAGAGATGGGTTTGACAAGGTTCTTCCCTTTTACATACTGCTGTCTATGTGGCTGTATCTTGTTTTTCCACTACTGCTACCACAACTATATTAT CATGCAAATGCTGTATTCTTCTTTGGTGGAGATAAAGATTTCTTGAGTTTTGTTTTAAAATTAAAGCTAAAGTATCTGTATTGCATTAAATATAATATGC ACACAGTGCTTTCCGTGGCACTGCATACAATCTGAGGCCTCCTCTCTCAGTTTTTATATAGATGGCGAGAACCTAAGTTTCAGTTGATTTTACAATTGAA ATGACTAAAAAACAAAGAAGACAACATTAAAACAATATTGTTTCTAATTGCTGAGGTTTAGCTGTCAGTTCTTTTTGCCCTTTGGGAATTCGGCATGGTT TCATTTTACTGCACTAGCCAAGAGACTTTACTTTTAAGAAGTATTAAAATTCTAAAATTCTATTAA

STAT1.u.f.1 (forward primer)
STAT1.u.r.5 (reverse primer)
Single exon skipping

Frame 0

GGGGRGPGASAAFSPAG*FRFPAQSLRRGSAAP GGSRLADPRPSRGDPARSGEAAPPRPRLALPDPA RRDVSVVRTSAA*LKIPGAGSPAL**QFSHGNQ TVPGTVVRKARLGARCQ*CFICHHPFS*PPVTA G*SI*SLFFGE*LLATA*HKEKQA*SSG*FSGRP NPDVYDHLQLSEGRKENSGKRPEI*SGSVGEYS EHSDVRQTERA*Q*SQKCEGQGYVYRA*NQEPG RFTR*I*LQMQNLAEQRTRDQWCGKE*SETRTAV TQEDVFNA*Q*EKGSSSQNNRVAECH*TYPECP D***TSGVEAETAERLYWGAAQCLLGSAAELVH YSCGESAASSAAA*KVGGIGTEIHLRT*PYHKKQ TSVMGPHLQSFPAAHSELVCGGKTALHANAPSE AAGLEDRGPVHCEVETVGEIARAEL*FESQSLI **RCE*EKYSKRI*EVQHFGHAHKSDEHGGVHQW QSGG*ISAPAIERTEKCWHQNE*GSSHRY*RAS LP*F*NPIVPAWFGN*PRDDLSARCGDLQRQPA PERLGLHPLVQHAGGGTQESVLLPDSTMCTMGSA FRSAELAVFFCHQKRSQCGPAEHVGREASWS*R QPRWSHSVDEVL*GKYK**KFSLLALD*KHPRT H*KTPAPSLE*WVHHGLHQQGARACPVEGPAAGD LPAAVQ*ELPGRGHHIHMGGAVPERRRT*LPCG *TLHEERTFCCYFP*HHSQLQSHGC*EYS*ESP EVSVSKY*QRPCLWKVLLQAKGSTRANGT*WP*R NWIYQD*VDFCV*SSPF*TSDHRQPAPHVS*GV *RGVSDSGLCRIRQYDEHSIEHEFFSSSLATVF LLICDSLLLLCSFTSCVSREMKERPANSLQPVDS K*IFL*LRNISYSEGHHASY*R*N*KAFSEEWV SQVKNIQIHPKYQDENEGPLGKEKLSNI*QMLC IKSVPNCYRLLDKSVVI*GTA*RRNGKFLWENSY MFSLL*V*LAVFHWFTCEIVQSQVYIQLYQSSF KGSHHGSGRGKMCILLHLSHWLFKDKDKF*GCT FPNSQVVFDIQS*IHSAFILVTYNYFYSSPKGVR LFTTTHSKVEINHRCR*TQKFNSCFLNGLLCPF CY*GGI*SISHKIGKGVEKAVTDNLNNTPEII* ESDHFKTHFLCNCIENCICFADICVFHICEWFHS LSCTFSRHFFEWMMFREVYCIFTFFLPYH*HKK *IKRWV*QGSSLLHTAVYVAVSCFSTTATTTIL SCKCCILLWWR*RFLEFCFKIKAKVSVLH*I*YA HSAFRGTAYNLRPPLSVFI*MART*VSVDFTIE MTKKQRRQH*NNIVSNC*GLAVSSFCPLGIRHG FILLH*PRDFTFKKY*NSKILL

Frame 1

VGAEGGRAPALPFLLPGSFAFLRRVCGGARLHR GDRAWQTPDRAEATQRARERLHRRAPA*PFRIL RAEMSQWYELQQLDSKFLEQVHQLYDDSFPMEIR QYLAQWLEKQDWEHAANDVSFATIRFHDLLSQL DDQYSRFSLENNFLLQHNIRKSKRNLQDNFQED PIQMSMIIYSCLKEERKILENAQRFNQAQSGNIQ STVMLDKQKELDSKVRNVKDKVMCIEHEIKSLE DLQDEYDFKCKTLQNREHETNGVAKSDQKQEQL LLKKMYLMLDNKRKEVVHKIIELLNVTELTQNAL INDELVEWKRRQQSACIGGPPNACLDQLQNWFT IVAESLQQVRQQLKKLEELEQKYTYEHDPITKN KQVLWDRTFSLFQQLIQSSFVVERQPCMPTHPQR PLVLKTGVQFTVKLRLLVKLQELNYNLKVKVLF DKDVNERNTVKGFRKFNILGTHTKVMNMEESTN GSLAAEFRHLQLKEQKNAGTRTNEGPLIVTEELH SLSFETQLCQPGLVIDLETTSLPVVVISNVSQL PSGWASILWYNMLVAEPRNLSFFLTPPCARWAQ LSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNA SPDGLIPWTRFCKENINDKNFPFWLWIESILEL IKKHLLPLWNDGCIMGFISKERERALLKDQQPG TFLLRFSESSREGAITFTWVERSQNGGEPDFHAV EPYTKKELSAVTFPDIIRNYKVMAAENIPENPL KYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPK GTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEF DEVSRIVGSVEFDSMMNTV*SMNFFHLLWRQFS FSSVIPSCYSVPSHPVFLGK*KKGQQIRCNLLI ASEFFSNSETSVTLKGIMHLTEGKIERHSLKSGF HK*KTSRYTQSIRTRMRVLWERRS*ATSSKCYA *SQCPTVIGCWINQWLFRELLDVGTVNFCGRIL TCFLCFKCNWQFSIGLPVK*FKAKFIYNYISPLS KVAIMDLVGGKCVFYYIFHIGYLKTKTNSKDVH FQIHKLCLISKAEYILLSSWSHTIIFTVLPREL GYSQPLIQKLKLTIDVDKLRNLIHVS*MGYFVLF VIRVVFSLLATKLGKE*KKQ*LTT*IIHQR*YE NQIISKLISYVTALRTAYVSLIYVFFTFANGSI LSPVLFPDTFLSG*CFVKYTVFLPFSFLITDTKS RLRDGFDKVLPFYILLSMWLYLVFPLLLPQLYY HANAVFFFGGDKDFLSFVLKLKLKYLYCIKYNM HTVLSVALHTI*GLLSQFLYRWREPKFQLILQLK *LKNKEDNIKTILFLIAEV*LSVLFALWEFGMV SFYCTSQETLLLRSIKILKFY*

Frame 2

WGRKGAGRQRCLFSCRVVSLSCAESAEGLGCTG GIAPGRPQTEQRRPSALGRGCTAAPPPSPSGSC AQRCLSGTNFSSLTQNSWSRFTSFMMTVFPWKS DSTWHSG*KSKTGSTLPMMFHLPPSVFMTSCHSW MINIVAFLWRITSCYSIT*GKASVIFRIIFRKT QSRCL*SFTAV*RKKGKFWKTPRDLIRLSRGIF RAQ*C*TNRKSLTVKSEM*RTRLCV*SMKSRAWK IYKMNMTSNAKPCRTENTRPMVWQRVIRNKNSC YSRRCI*CLTIRERK*FTK**SC*MSLNLPRMP *LMMN*WSGSGDSRAPVLGGRPMLAWISCRTGSL *LRRVCSKFGSSLKSWRNWNRNTPTNMTLSQKT NKCYGTAPSVFSSSSFRARLWWKDSPACQRTLR GRWS*RQGSSSL*S*DCW*NCKS*III*KSKSYL IKM*MREIQ*KDLGSSTFWARTQK**TWRSPPM AVWRLNFGTCN*KNRKMLAPERMRVLSSLLKSF TPLVLKPNCASLVW*LTSRRPLCPLW*SPTSASS RAVGPPSFGTTCWWRNPGICPSS*LHHVHDGLS FQKC*VGSFLLSPKEVSMWTS*TCWERSFLVLT PAPMVSFRGRGFVRKI*MIKIFPSGFGLKAS*NS LKNTCSLSGMMGASWASSARSESVPC*RTSSRG PSCCGSVRAPGKGPSHSHGWSGPRTEANLTSMR LNPTRRKNFLLLLSLTSFAITKSWLLRIFLRIP* SICIQILTKTMPLESITPGQRKHQSQWNLMALK ELDISRLS*FLCLKFTLLDFRPQTTCSPCLLRS LTRCLG*WAL*NSTV**TQYRA*IFFIFSGDSFP SHL*FPPATLFLHILCF*GNERKASKFAATC** QVNFSLTQKHQLL*RASCILLKVKLKGIL*RVG FTSEKHPDTPKVSGRE*GSFGKGEVKQHLANVMH KVSAQLL*VVG*ISGYLGNCLT*ER*ISVGEFL HVFFALSVTGSFPLVYL*NSSKPSLYTIISVLF QR*PSWIW*GENVYFITSFTLAI*RQRQILRMYI SKFTSCV*YPKLNTFCFHLGHIQLFLQFSQGS* AIHNHSFKS*N*P*M*INSEI*FMFLKWATLSF LLLGWYLVY*PQNWERSRKSSN*QLE*YTRDNMR IRSFQNSFPM*LH*ELHMFR*YMCFSHLRMVPF SLLYFFQTLF*VDDVS*SILYFYLFPSLSLTQK VD*EMGLTRFFPFTYCCLCGCILFFHYCYHNYII MQMLYSSLVEIKIS*VLF*N*S*SICIALNIIC TQCFPWHCIQSEASSLSFYIDGENLSFS*FYN* ND*KTKKTTLKQYCF*LLRFSCQFFLPFGNSAWF HFTALAKRLYF*EVLKF*NSI

Sequence STAT1.cAug05

GGTGGGGGCGGAAGGGGGCCGGGCGCCAGCGCTGCCTTTTCTCCTGCCGGGTAGTTTCGCTTTCCTGCGCAGAGTCTGCGGAGGGGCTCGGCTGCACCGG GGGGATCGCGCCTGGCAGACCCCAGACCGAGCAGAGGCGACCCAGCGCGCTCGGGAGAGGCTGCACCGCCGCGCCCCCGCCTAGCCCTTCCGGATCCTGC GCGCAGAAAAGTTTCATTTGCTGTATGCCATCCTCGAGAGCTGTCTAGGTTAACGTTCGCACTCTGTGTATATAACCTCGACAGTCTTGGCACCTAACGT GCTGTGCGTAGCTGCTCCTTTGGTTGAATCCCCAGGCCCTTGTTGGGGCACAAGGTGGCAGGATGTCTCAGTGGTACGAACTTCAGCAGCTTGACTCAAA ATTCCTGGAGCAGGTTCACCAGCTTTATGATGACAGTTTTCCCATGGAAATCAGACAGTACCTGGCACAGTGGTTAGAAAAGCAAGACTGGGAGCACGCT GCCAATGATGTTTCATTTGCCACCATCCGTTTTCATGACCTCCTGTCACAGCTGGATGATCAATATAGTCGCTTTTCTTTGGAGAATAACTTCTTGCTAC AGCATAACATAAGGAAAAGCAAGCGTAATCTTCAGGATAATTTTCAGGAAGACCCAATCCAGATGTCTATGATCATTTACAGCTGTCTGAAGGAAGAAAG GAAAATTCTGGAAAACGCCCAGAGATTTAATCAGGCTCAGTCGGGGAATATTCAGAGCACAGTGATGTTAGACAAACAGAAAGAGCTTGACAGTAAAGTC AGAAATGTGAAGGACAAGGTTATGTGTATAGAGCATGAAATCAAGAGCCTGGAAGATTTACAAGATGAATATGACTTCAAATGCAAAACCTTGCAGAACA GAGAACACGAGACCAATGGTGTGGCAAAGAGTGATCAGAAACAAGAACAGCTGTTACTCAAGAAGATGTATTTAATGCTTGACAATAAGAGAAAGGAAGT AGTTCACAAAATAATAGAGTTGCTGAATGTCACTGAACTTACCCAGAATGCCCTGATTAATGATGAACTAGTGGAGTGGAAGCGGAGACAGCAGAGCGCC TGTATTGGGGGGCCGCCCAATGCTTGCTTGGATCAGCTGCAGAACTGGTTCACTATAGTTGCGGAGAGTCTGCAGCAAGTTCGGCAGCAGCTTAAAAAGT TGGAGGAATTGGAACAGAAATACACCTACGAACATGACCCTATCACAAAAAACAAACAAGTGTTATGGGACCGCACCTTCAGTCTTTTCCAGCAGCTCAT TCAGAGCTCGTTTGTGGTGGAAAGACAGCCCTGCATGCCAACGCACCCTCAGAGGCCGCTGGTCTTGAAGACAGGGGTCCAGTTCACTGTGAAGTTGAGA CTGTTGGTGAAATTGCAAGAGCTGAATTATAATTTGAAAGTCAAAGTCTTATTTGATAAAGATGTGAATGAGAGAAATACAGTAAAAGGATTTAGGAAGT TCAACATTTTGGGCACGCACACAAAAGTGATGAACATGGAGGAGTCCACCAATGGCAGTCTGGCGGCTGAATTTCGGCACCTGCAATTGAAAGAACAGAA AAATGCTGGCACCAGAACGAATGAGGGTCCTCTCATCGTTACTGAAGAGCTTCACTCCCTTAGTTTTGAAACCCAATTGTGCCAGCCTGGTTTGGTAATT GACCTCGAGACGACCTCTCTGCCCGTTGTGGTGATCTCCAACGTCAGCCAGCTCCCGAGCGGTTGGGCCTCCATCCTTTGGTACAACATGCTGGTGGCGG AACCCAGGAATCTGTCCTTCTTCCTGACTCCACCATGTGCACGATGGGCTCAGCTTTCAGAAGTGCTGAGTTGGCAGTTTTCTTCTGTCACCAAAAGAGG TCTCAATGTGGACCAGCTGAACATGTTGGGAGAGAAGCTTCTTGGTCCTAACGCCAGCCCCGATGGTCTCATTCCGTGGACGAGGTTTTGTAAGGAAAAT ATAAATGATAAAAATTTTCCCTTCTGGCTTTGGATTGAAAGCATCCTAGAACTCATTAAAAAACACCTGCTCCCTCTCTGGAATGATGGGTGCATCATGG GCTTCATCAGCAAGGAGCGAGAGCGTGCCCTGTTGAAGGACCAGCAGCCGGGGACCTTCCTGCTGCGGTTCAGTGAGAGCTCCCGGGAAGGGGCCATCAC ATTCACATGGGTGGAGCGGTCCCAGAACGGAGGCGAACCTGACTTCCATGCGGTTGAACCCTACACGAAGAAAGAACTTTCTGCTGTTACTTTCCCTGAC ATCATTCGCAATTACAAAGTCATGGCTGCTGAGAATATTCCTGAGAATCCCCTGAAGTATCTGTATCCAAATATTGACAAAGACCATGCCTTTGGAAAGT ATTACTCCAGGCCAAAGGAAGCACCAGAGCCAATGGAACTTGATGGCCCTAAAGGAACTGGATATATCAAGACTGAGTTGATTTCTGTGTCTGAAGTGTA AGTGAACACAGAAGAGTGACATGTTTACAAACCTCAAGCCAGCCTTGCTCCTGGCTGGGGCCTGTTGAAGATGCTTGTATTTTACTTTTCCATTGTAATT GCTATCGCCATCACAGCTGAACTTGTTGAGATCCCCGTGTTACTGCCTATCAGCATTTTACTACTTTAAAAAAAAAAAAAAAGCCAAAAACCAAATTTGT ATTTAAGGTATATAAATTTTCCCAAAACTGATACCCTTTGAAAAAGTATAAATAAAATGAGCAAAAGTTGATCAGAGTGGGAAAGTAGTTCTTTTCAATC TAGAAAAGGCCAAAGTAATGATTGAGATACACTGTCTCCACTTGCTTTGATTTTGTTGTTTCATTTTATAAAAGGTAGAAAAAATTTTGGAAATGTCATT GTCAGTTATTTGGCCTGCAGCACTGTCTTGGGGTGAATGGATGTAGCCTTCATGTAAAAACACTGTGTGGAGCAGCTTTATCTGCATTCAAACCTCAAGG TAGGGATGAGGGACTCCCCAGACATTTCTCTGGTGCTTTTCTGTCCAGGGTAAGCCACGAGGCATTGTCATCTCAGGGTAGTGCACCGCACATGCTCACA CCTAGGCTTACCCAGGCAGAAGCGGCACAGATTCCAGTCTGGCTATTGCTTATCACATCCCTGGAGTGTGAAACATTTCCCAAGGGGCTGGGCTGGGGAC ATGAGCCTCCCATGAGCTGTACTTTTGCAAATGTATTTTACAAGTGTATGCACTTACCCAAAATAAAAATATAACGTGATAATTCAATTACAGACAAAAG ATAAAGTGTGTAAG

STAT1.u.f.1 (forward primer)
STAT1.u.r.5 (reverse primer)
Single exon skipping

Frame 0

GGGGRGPGASAAFSPAG*FRFPAQSLRRGSAAP GGSRLADPRPSRGDPARSGEAAPPRPRLALPDPA RRKVSFAVCHPRELSRLTFALCVYNLDSLGT*R AVRSCSFG*IPRPLLGHKVAGCLSGTNFSSLTQ NSWSRFTSFMMTVFPWKSDSTWHSG*KSKTGSTL PMMFHLPPSVFMTSCHSWMINIVAFLWRITSCY SIT*GKASVIFRIIFRKTQSRCL*SFTAV*RKK GKFWKTPRDLIRLSRGIFRAQ*C*TNRKSLTVKS EM*RTRLCV*SMKSRAWKIYKMNMTSNAKPCRT ENTRPMVWQRVIRNKNSCYSRRCI*CLTIRERK *FTK**SC*MSLNLPRMP*LMMN*WSGSGDSRAP VLGGRPMLAWISCRTGSL*LRRVCSKFGSSLKS WRNWNRNTPTNMTLSQKTNKCYGTAPSVFSSSS FRARLWWKDSPACQRTLRGRWS*RQGSSSL*S*D CW*NCKS*III*KSKSYLIKM*MREIQ*KDLGS STFWARTQK**TWRSPPMAVWRLNFGTCN*KNR KMLAPERMRVLSSLLKSFTPLVLKPNCASLVW*L TSRRPLCPLW*SPTSASSRAVGPPSFGTTCWWR NPGICPSS*LHHVHDGLSFQKC*VGSFLLSPKE VSMWTS*TCWERSFLVLTPAPMVSFRGRGFVRKI *MIKIFPSGFGLKAS*NSLKNTCSLSGMMGASW ASSARSESVPC*RTSSRGPSCCGSVRAPGKGPS HSHGWSGPRTEANLTSMRLNPTRRKNFLLLLSLT SFAITKSWLLRIFLRIP*SICIQILTKTMPLES ITPGQRKHQSQWNLMALKELDISRLS*FLCLKC K*TQKSDMFTNLKPALLLAGAC*RCLYFTFPL*L LSPSQLNLLRSPCYCLSAFYYFKKKKKAKNQIC I*GI*IFPKLIPFEKV*IK*AKVDQSGKVVLFN LEKAKVMIEIHCLHLL*FCCFIL*KVEKILEMSL SVIWPAALSWGEWM*PSCKNTVWSSFICIQTSR *G*GTPQTFLWCFSVQGKPRGIVISG*CTAHAH T*AYPGRSGTDSSLAIAYHIPGV*NISQGAGLGT *ASHELYFCKCILQVYALTQNKNIT**FNYRQK IKCV

Frame 1

VGAEGGRAPALPFLLPGSFAFLRRVCGGARLHR GDRAWQTPDRAEATQRARERLHRRAPA*PFRIL RAEKFHLLYAILESCLG*RSHSVYITSTVLAPNV LCVAAPLVESPGPCWGTRWQDVSVVRTSAA*LK IPGAGSPAL**QFSHGNQTVPGTVVRKARLGAR CQ*CFICHHPFS*PPVTAG*SI*SLFFGE*LLAT A*HKEKQA*SSG*FSGRPNPDVYDHLQLSEGRK ENSGKRPEI*SGSVGEYSEHSDVRQTERA*Q*S QKCEGQGYVYRA*NQEPGRFTR*I*LQMQNLAEQ RTRDQWCGKE*SETRTAVTQEDVFNA*Q*EKGS SSQNNRVAECH*TYPECPD***TSGVEAETAER LYWGAAQCLLGSAAELVHYSCGESAASSAAA*KV GGIGTEIHLRT*PYHKKQTSVMGPHLQSFPAAH SELVCGGKTALHANAPSEAAGLEDRGPVHCEVE TVGEIARAEL*FESQSLI**RCE*EKYSKRI*EV QHFGHAHKSDEHGGVHQWQSGG*ISAPAIERTE KCWHQNE*GSSHRY*RASLP*F*NPIVPAWFGN *PRDDLSARCGDLQRQPAPERLGLHPLVQHAGGG TQESVLLPDSTMCTMGSAFRSAELAVFFCHQKR SQCGPAEHVGREASWS*RQPRWSHSVDEVL*GK YK**KFSLLALD*KHPRTH*KTPAPSLE*WVHHG LHQQGARACPVEGPAAGDLPAAVQ*ELPGRGHH IHMGGAVPERRRT*LPCG*TLHEERTFCCYFP* HHSQLQSHGC*EYS*ESPEVSVSKY*QRPCLWKV LLQAKGSTRANGT*WP*RNWIYQD*VDFCV*SV SEHRRVTCLQTSSQPCSWLGPVEDACILLFHCN CYRHHS*TC*DPRVTAYQHFTTLKKKKKPKTKFV FKVYKFSQN*YPLKKYK*NEQKLIRVGK*FFSI *KRPK**LRYTVSTCFDFVVSFYKR*KKFWKCH CQLFGLQHCLGVNGCSLHVKTLCGAALSAFKPQG RDEGLPRHFSGAFLSRVSHEALSSQGSAPHMLT PRLTQAEAAQIPVWLLLITSLECETFPKGLGWG HEPPMSCTFANVFYKCMHLPKIKI*RDNSITDKR *SV*

Frame 2

WGRKGAGRQRCLFSCRVVSLSCAESAEGLGCTG GIAPGRPQTEQRRPSALGRGCTAAPPPSPSGSC AQKSFICCMPSSRAV*VNVRTLCI*PRQSWHLT CCA*LLLWLNPQALVGAQGGRMSQWYELQQLDSK FLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHA ANDVSFATIRFHDLLSQLDDQYSRFSLENNFLL QHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEER KILENAQRFNQAQSGNIQSTVMLDKQKELDSKV RNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQN REHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEV VHKIIELLNVTELTQNALINDELVEWKRRQQSA CIGGPPNACLDQLQNWFTIVAESLQQVRQQLKK LEELEQKYTYEHDPITKNKQVLWDRTFSLFQQLI QSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLR LLVKLQELNYNLKVKVLFDKDVNERNTVKGFRK FNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQK NAGTRTNEGPLIVTEELHSLSFETQLCQPGLVI DLETTSLPVVVISNVSQLPSGWASILWYNMLVA EPRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRG LNVDQLNMLGEKLLGPNASPDGLIPWTRFCKEN INDKNFPFWLWIESILELIKKHLLPLWNDGCIM GFISKERERALLKDQQPGTFLLRFSESSREGAIT FTWVERSQNGGEPDFHAVEPYTKKELSAVTFPD IIRNYKVMAAENIPENPLKYLYPNIDKDHAFGK YYSRPKEAPEPMELDGPKGTGYIKTELISVSEV* VNTEE*HVYKPQASLAPGWGLLKMLVFYFSIVI AIAITAELVEIPVLLPISILLL*KKKKSQKPNL YLRYINFPKTDTL*KSINKMSKS*SEWESSSFQS RKGQSND*DTLSPLALILLFHFIKGRKNFGNVI VSYLACSTVLG*MDVAFM*KHCVEQLYLHSNLK VGMRDSPDISLVLFCPG*ATRHCHLRVVHRTCSH LGLPRQKRHRFQSGYCLSHPWSVKHFPRGWAGD MSLP*AVLLQMYFTSVCTYPK*KYNVIIQLQTK DKVCK

Sequence STAT1.aAug05

GGTGGGGGCGGAAGGGGGCCGGGCGCCAGCGCTGCCTTTTCTCCTGCCGGGTAGTTTCGCTTTCCTGCGCAGAGTCTGCGGAGGGGCTCGGCTGCACCGG GGGGATCGCGCCTGGCAGACCCCAGACCGAGCAGAGGCGACCCAGCGCGCTCGGGAGAGGCTGCACCGCCGCGCCCCCGCCTAGCCCTTCCGGATCCTGC GCGCAGAAAAGTTTCATTTGCTGTATGCCATCCTCGAGAGCTGTCTAGGTTAACGTTCGCACTCTGTGTATATAACCTCGACAGTCTTGGCACCTAACGT GCTGTGCGTAGCTGCTCCTTTGGTTGAATCCCCAGGCCCTTGTTGGGGCACAAGGTGGCAGGATGTCTCAGTGGTACGAACTTCAGCAGCTTGACTCAAA ATTCCTGGAGCAGGTTCACCAGCTTTATGATGACAGTTTTCCCATGGAAATCAGACAGTACCTGGCACAGTGGTTAGAAAAGCAAGACTGGGAGCACGCT GCCAATGATGTTTCATTTGCCACCATCCGTTTTCATGACCTCCTGTCACAGCTGGATGATCAATATAGTCGCTTTTCTTTGGAGAATAACTTCTTGCTAC AGCATAACATAAGGAAAAGCAAGCGTAATCTTCAGGATAATTTTCAGGAAGACCCAATCCAGATGTCTATGATCATTTACAGCTGTCTGAAGGAAGAAAG GAAAATTCTGGAAAACGCCCAGAGATTTAATCAGGCTCAGTCGGGGAATATTCAGAGCACAGTGATGTTAGACAAACAGAAAGAGCTTGACAGTAAAGTC AGAAATGTGAAGGACAAGGTTATGTGTATAGAGCATGAAATCAAGAGCCTGGAAGATTTACAAGATGAATATGACTTCAAATGCAAAACCTTGCAGAACA GAGAACACGAGACCAATGGTGTGGCAAAGAGTGATCAGAAACAAGAACAGCTGTTACTCAAGAAGATGTATTTAATGCTTGACAATAAGAGAAAGGAAGT AGTTCACAAAATAATAGAGTTGCTGAATGTCACTGAACTTACCCAGAATGCCCTGATTAATGATGAACTAGTGGAGTGGAAGCGGAGACAGCAGAGCGCC TGTATTGGGGGGCCGCCCAATGCTTGCTTGGATCAGCTGCAGAACTGGTTCACTATAGTTGCGGAGAGTCTGCAGCAAGTTCGGCAGCAGCTTAAAAAGT TGGAGGAATTGGAACAGAAATACACCTACGAACATGACCCTATCACAAAAAACAAACAAGTGTTATGGGACCGCACCTTCAGTCTTTTCCAGCAGCTCAT TCAGAGCTCGTTTGTGGTGGAAAGACAGCCCTGCATGCCAACGCACCCTCAGAGGCCGCTGGTCTTGAAGACAGGGGTCCAGTTCACTGTGAAGTTGAGA CTGTTGGTGAAATTGCAAGAGCTGAATTATAATTTGAAAGTCAAAGTCTTATTTGATAAAGATGTGAATGAGAGAAATACAGTAAAAGGATTTAGGAAGT TCAACATTTTGGGCACGCACACAAAAGTGATGAACATGGAGGAGTCCACCAATGGCAGTCTGGCGGCTGAATTTCGGCACCTGCAATTGAAAGAACAGAA AAATGCTGGCACCAGAACGAATGAGGGTCCTCTCATCGTTACTGAAGAGCTTCACTCCCTTAGTTTTGAAACCCAATTGTGCCAGCCTGGTTTGGTAATT GACCTCGAGACGACCTCTCTGCCCGTTGTGGTGATCTCCAACGTCAGCCAGCTCCCGAGCGGTTGGGCCTCCATCCTTTGGTACAACATGCTGGTGGCGG AACCCAGGAATCTGTCCTTCTTCCTGACTCCACCATGTGCACGATGGGCTCAGCTTTCAGAAGTGCTGAGTTGGCAGTTTTCTTCTGTCACCAAAAGAGG TCTCAATGTGGACCAGCTGAACATGTTGGGAGAGAAGCTTCTTGGTCCTAACGCCAGCCCCGATGGTCTCATTCCGTGGACGAGGTTTTGTAAGGAAAAT ATAAATGATAAAAATTTTCCCTTCTGGCTTTGGATTGAAAGCATCCTAGAACTCATTAAAAAACACCTGCTCCCTCTCTGGAATGATGGGTGCATCATGG GCTTCATCAGCAAGGAGCGAGAGCGTGCCCTGTTGAAGGACCAGCAGCCGGGGACCTTCCTGCTGCGGTTCAGTGAGAGCTCCCGGGAAGGGGCCATCAC ATTCACATGGGTGGAGCGGTCCCAGAACGGAGGCGAACCTGACTTCCATGCGGTTGAACCCTACACGAAGAAAGAACTTTCTGCTGTTACTTTCCCTGAC ATCATTCGCAATTACAAAGTCATGGCTGCTGAGAATATTCCTGAGAATCCCCTGAAGTATCTGTATCCAAATATTGACAAAGACCATGCCTTTGGAAAGT ATTACTCCAGGCCAAAGGAAGCACCAGAGCCAATGGAACTTGATGGCCCTAAAGGAACTGGATATATCAAGACTGAGTTGATTTCTGTGTCTGAAGTTCA CCCTTCTAGACTTCAGACCACAGACAACCTGCTCCCCATGTCTCCTGAGGAGTTTGACGAGGTGTCTCGGATAGTGGGCTCTGTAGAATTCGACAGTATG ATGAACACAGTATAGAGCATGAATTTTTTTCATCTTCTCTGGCGACAGTTTTCCTTCTCATCTGTGATTCCCTCCTGCTACTCTGTTCCTTCACATCCTG TGTTTCTAGGGAAATGAAAGAAAGGCCAGCAAATTCGCTGCAACCTGTTGATAGCAAGTGAATTTTTCTCTAACTCAGAAACATCAGTTACTCTGAAGGG CATCATGCATCTTACTGAAGGTAAAATTGAAAGGCATTCTCTGAAGAGTGGGTTTCACAAGTGAAAAACATCCAGATACACCCAAAGTATCAGGACGAGA ATGAGGGTCCTTTGGGAAAGGAGAAGTTAAGCAACATCTAGCAAATGTTATGCATAAAGTCAGTGCCCAACTGTTATAGGTTGTTGGATAAATCAGTGGT TATTTAGGGAACTGCTTGACGTAGGAACGGTAAATTTCTGTGGGAGAATTCTTACATGTTTTCTTTGCTTTAAGTGTAACTGGCAGTTTTCCATTGGTTT ACCTGTGAAATAGTTCAAAGCCAAGTTTATATACAATTATATCAGTCCTCTTTCAAAGGTAGCCATCATGGATCTGGTAGGGGGAAAATGTGTATTTTAT TACATCTTTCACATTGGCTATTTAAAGACAAAGACAAATTCTGTTTCTTGAGAAGAGAATATTAGCTTTACTGTTTGTTATGGCTTAATGACACTAGCTA ATATCAATAGAAGGATGTACATTTCCAAATTCACAAGTTGTGTTTGATATCCAAAGCTGAATACATTCTGCTTTCATCTTGGTCACATACAATTATTTTT ACAGTTCTCCCAAGGGAGTTAGGCTATTCACAACCACTCATTCAAAAGTTGAAATTAACCATAGATGTAGATAAACTCAGAAATTTAATTCATGTTTCTT AAATGGGCTACTTTGTCCTTTTTGTTATTAGGGTGGTATTTAGTCTATTAGCCACAAAATTGGGAAAGGAGTAGAAAAAGCAGTAACTGACAACTTGAAT AATACACCAGAGATAATATGAGAATCAGATCATTTCAAAACTCATTTCCTATGTAACTGCATTGAGAACTGCATATGTTTCGCTGATATATGTGTTTTTC ACATTTGCGAATGGTTCCATTCTCTCTCCTGTACTTTTTCCAGACACTTTTTTGAGTGGATGATGTTTCGTGAAGTATACTGTATTTTTACCTTTTTCCT TCCTTATCACTGACACAAAAAGTAGATTAAGAGATGGGTTTGACAAGGTTCTTCCCTTTTACATACTGCTGTCTATGTGGCTGTATCTTGTTTTTCCACT ACTGCTACCACAACTATATTATCATGCAAATGCTGTATTCTTCTTTGGTGGAGATAAAGATTTCTTGAGTTTTGTTTTAAAATTAAAGCTAAAGTATCTG TATTGCATTAAATATAATATGCACACAGTGCTTTCCGTGGCACTGCATACAATCTGAGGCCTCCTCTCTCAGTTTTTATATAGATGGCGAGAACCTAAGT TTCAGTTGATTTTACAATTGAAATGACTAAAAAACAAAGAAGACAACATTAAAACAATATTGTTTCTAATTGCTGAGGTTTAGCTGTCAGTTCTTTTTGC CCTTTGGGAATTCGGCATGGTTTCATTTTACTGCACTAGCCAAGAGACTTTACTTTTAAGAAGTATTAAAATTCTAAAATTCTATTAA

STAT1.u.f.1 (forward primer)
STAT1.u.r.5 (reverse primer)
Single exon skipping

Frame 0

GGGGRGPGASAAFSPAG*FRFPAQSLRRGSAAP GGSRLADPRPSRGDPARSGEAAPPRPRLALPDPA RRKVSFAVCHPRELSRLTFALCVYNLDSLGT*R AVRSCSFG*IPRPLLGHKVAGCLSGTNFSSLTQ NSWSRFTSFMMTVFPWKSDSTWHSG*KSKTGSTL PMMFHLPPSVFMTSCHSWMINIVAFLWRITSCY SIT*GKASVIFRIIFRKTQSRCL*SFTAV*RKK GKFWKTPRDLIRLSRGIFRAQ*C*TNRKSLTVKS EM*RTRLCV*SMKSRAWKIYKMNMTSNAKPCRT ENTRPMVWQRVIRNKNSCYSRRCI*CLTIRERK *FTK**SC*MSLNLPRMP*LMMN*WSGSGDSRAP VLGGRPMLAWISCRTGSL*LRRVCSKFGSSLKS WRNWNRNTPTNMTLSQKTNKCYGTAPSVFSSSS FRARLWWKDSPACQRTLRGRWS*RQGSSSL*S*D CW*NCKS*III*KSKSYLIKM*MREIQ*KDLGS STFWARTQK**TWRSPPMAVWRLNFGTCN*KNR KMLAPERMRVLSSLLKSFTPLVLKPNCASLVW*L TSRRPLCPLW*SPTSASSRAVGPPSFGTTCWWR NPGICPSS*LHHVHDGLSFQKC*VGSFLLSPKE VSMWTS*TCWERSFLVLTPAPMVSFRGRGFVRKI *MIKIFPSGFGLKAS*NSLKNTCSLSGMMGASW ASSARSESVPC*RTSSRGPSCCGSVRAPGKGPS HSHGWSGPRTEANLTSMRLNPTRRKNFLLLLSLT SFAITKSWLLRIFLRIP*SICIQILTKTMPLES ITPGQRKHQSQWNLMALKELDISRLS*FLCLKF TLLDFRPQTTCSPCLLRSLTRCLG*WAL*NSTV* *TQYRA*IFFIFSGDSFPSHL*FPPATLFLHIL CF*GNERKASKFAATC**QVNFSLTQKHQLL*R ASCILLKVKLKGIL*RVGFTSEKHPDTPKVSGRE *GSFGKGEVKQHLANVMHKVSAQLL*VVG*ISG YLGNCLT*ER*ISVGEFLHVFFALSVTGSFPLV YL*NSSKPSLYTIISVLFQR*PSWIW*GENVYFI TSFTLAI*RQRQILFLEKRILALLFVMA**H*L ISIEGCTFPNSQVVFDIQS*IHSAFILVTYNYF YSSPKGVRLFTTTHSKVEINHRCR*TQKFNSCFL NGLLCPFCY*GGI*SISHKIGKGVEKAVTDNLN NTPEII*ESDHFKTHFLCNCIENCICFADICVF HICEWFHSLSCTFSRHFFEWMMFREVYCIFTFFL PYH*HKK*IKRWV*QGSSLLHTAVYVAVSCFST TATTTILSCKCCILLWWR*RFLEFCFKIKAKVS VLH*I*YAHSAFRGTAYNLRPPLSVFI*MART*V SVDFTIEMTKKQRRQH*NNIVSNC*GLAVSSFC PLGIRHGFILLH*PRDFTFKKY*NSKILL

Frame 1

VGAEGGRAPALPFLLPGSFAFLRRVCGGARLHR GDRAWQTPDRAEATQRARERLHRRAPA*PFRIL RAEKFHLLYAILESCLG*RSHSVYITSTVLAPNV LCVAAPLVESPGPCWGTRWQDVSVVRTSAA*LK IPGAGSPAL**QFSHGNQTVPGTVVRKARLGAR CQ*CFICHHPFS*PPVTAG*SI*SLFFGE*LLAT A*HKEKQA*SSG*FSGRPNPDVYDHLQLSEGRK ENSGKRPEI*SGSVGEYSEHSDVRQTERA*Q*S QKCEGQGYVYRA*NQEPGRFTR*I*LQMQNLAEQ RTRDQWCGKE*SETRTAVTQEDVFNA*Q*EKGS SSQNNRVAECH*TYPECPD***TSGVEAETAER LYWGAAQCLLGSAAELVHYSCGESAASSAAA*KV GGIGTEIHLRT*PYHKKQTSVMGPHLQSFPAAH SELVCGGKTALHANAPSEAAGLEDRGPVHCEVE TVGEIARAEL*FESQSLI**RCE*EKYSKRI*EV QHFGHAHKSDEHGGVHQWQSGG*ISAPAIERTE KCWHQNE*GSSHRY*RASLP*F*NPIVPAWFGN *PRDDLSARCGDLQRQPAPERLGLHPLVQHAGGG TQESVLLPDSTMCTMGSAFRSAELAVFFCHQKR SQCGPAEHVGREASWS*RQPRWSHSVDEVL*GK YK**KFSLLALD*KHPRTH*KTPAPSLE*WVHHG LHQQGARACPVEGPAAGDLPAAVQ*ELPGRGHH IHMGGAVPERRRT*LPCG*TLHEERTFCCYFP* HHSQLQSHGC*EYS*ESPEVSVSKY*QRPCLWKV LLQAKGSTRANGT*WP*RNWIYQD*VDFCV*SS PF*TSDHRQPAPHVS*GV*RGVSDSGLCRIRQY DEHSIEHEFFSSSLATVFLLICDSLLLLCSFTSC VSREMKERPANSLQPVDSK*IFL*LRNISYSEG HHASY*R*N*KAFSEEWVSQVKNIQIHPKYQDE NEGPLGKEKLSNI*QMLCIKSVPNCYRLLDKSVV I*GTA*RRNGKFLWENSYMFSLL*V*LAVFHWF TCEIVQSQVYIQLYQSSFKGSHHGSGRGKMCIL LHLSHWLFKDKDKFCFLRREY*LYCLLWLNDTS* YQ*KDVHFQIHKLCLISKAEYILLSSWSHTIIF TVLPRELGYSQPLIQKLKLTIDVDKLRNLIHVS *MGYFVLFVIRVVFSLLATKLGKE*KKQ*LTT*I IHQR*YENQIISKLISYVTALRTAYVSLIYVFF TFANGSILSPVLFPDTFLSG*CFVKYTVFLPFS FLITDTKSRLRDGFDKVLPFYILLSMWLYLVFPL LLPQLYYHANAVFFFGGDKDFLSFVLKLKLKYL YCIKYNMHTVLSVALHTI*GLLSQFLYRWREPK FQLILQLK*LKNKEDNIKTILFLIAEV*LSVLFA LWEFGMVSFYCTSQETLLLRSIKILKFY*

Frame 2

WGRKGAGRQRCLFSCRVVSLSCAESAEGLGCTG GIAPGRPQTEQRRPSALGRGCTAAPPPSPSGSC AQKSFICCMPSSRAV*VNVRTLCI*PRQSWHLT CCA*LLLWLNPQALVGAQGGRMSQWYELQQLDSK FLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHA ANDVSFATIRFHDLLSQLDDQYSRFSLENNFLL QHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEER KILENAQRFNQAQSGNIQSTVMLDKQKELDSKV RNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQN REHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEV VHKIIELLNVTELTQNALINDELVEWKRRQQSA CIGGPPNACLDQLQNWFTIVAESLQQVRQQLKK LEELEQKYTYEHDPITKNKQVLWDRTFSLFQQLI QSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLR LLVKLQELNYNLKVKVLFDKDVNERNTVKGFRK FNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQK NAGTRTNEGPLIVTEELHSLSFETQLCQPGLVI DLETTSLPVVVISNVSQLPSGWASILWYNMLVA EPRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRG LNVDQLNMLGEKLLGPNASPDGLIPWTRFCKEN INDKNFPFWLWIESILELIKKHLLPLWNDGCIM GFISKERERALLKDQQPGTFLLRFSESSREGAIT FTWVERSQNGGEPDFHAVEPYTKKELSAVTFPD IIRNYKVMAAENIPENPLKYLYPNIDKDHAFGK YYSRPKEAPEPMELDGPKGTGYIKTELISVSEVH PSRLQTTDNLLPMSPEEFDEVSRIVGSVEFDSM MNTV*SMNFFHLLWRQFSFSSVIPSCYSVPSHP VFLGK*KKGQQIRCNLLIASEFFSNSETSVTLKG IMHLTEGKIERHSLKSGFHK*KTSRYTQSIRTR MRVLWERRS*ATSSKCYA*SQCPTVIGCWINQW LFRELLDVGTVNFCGRILTCFLCFKCNWQFSIGL PVK*FKAKFIYNYISPLSKVAIMDLVGGKCVFY YIFHIGYLKTKTNSVS*EENISFTVCYGLMTLA NINRRMYISKFTSCV*YPKLNTFCFHLGHIQLFL QFSQGS*AIHNHSFKS*N*P*M*INSEI*FMFL KWATLSFLLLGWYLVY*PQNWERSRKSSN*QLE *YTRDNMRIRSFQNSFPM*LH*ELHMFR*YMCFS HLRMVPFSLLYFFQTLF*VDDVS*SILYFYLFP SLSLTQKVD*EMGLTRFFPFTYCCLCGCILFFH YCYHNYIIMQMLYSSLVEIKIS*VLF*N*S*SIC IALNIICTQCFPWHCIQSEASSLSFYIDGENLS FS*FYN*ND*KTKKTTLKQYCF*LLRFSCQFFL PFGNSAWFHFTALAKRLYF*EVLKF*NSI