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Sequence INSR.bAug05
TCCCGCCGCCCGCCCGCCACCCGCCAGCCCAGGTGCCCGCCCGCCAGTCAGCTAGTCCGTCGGTCCGCGCGTCCCTCTGTCCCGGAGCCCGCAGATCGCGACCCAGAGCGCGCGGGGCCGAGAGCCGAGAGACAGTCCCGGGCGCAGCGCGGAGCTCCGGGCCCCGAGATCCTGGGACGGGGCCCGGGCCGCAGCGGCCG
GGGGGTCGGGGCCACCACCGCAAGGGCCTCCGCTCAGTATTTGTAGCTGGCGAAGCCGCGCGCGCCCTTCCCGGGGCTGCCTCTGGGCCCTCCCCGGCAG
GGGGGCTGCGGCCCGCGGGTCGCGGGCGTGGAAGAGAAGGACGCGCGGCCCCCAGCGCCTCTTGGGTGGCCGCCTCGGAGCATGACCCCCGCGGGCCAGC
GCCGCGCGCTCTGATCCGAGGAGACCCCGCGCTCCCGCAGCCATGGCCACCGGGGGCCGGCGGGGGGCGGCGGCCGCGCCGCTGCTGGTGGCGGTGGCCG
CGCTGCTACTGGGCGCCGCGGGCCACCTGTACCCCGGAGAGGTGTGTCCCGGCATGGATATCCGGAACAACCTCACTAGGTTGCATGAGCTGGAGAATTG
CTCTGTCATCGAAGGACACTTGCAGATACTCTTGATGTTCAAAACGAGGCCCGAAGATTTCCGAGACCTCAGTTTCCCCAAACTCATCATGATCACTGAT
TACTTGCTGCTCTTCCGGGTCTATGGGCTCGAGAGCCTGAAGGACCTGTTCCCCAACCTCACGGTCATCCGGGGATCACGACTGTTCTTTAACTACGCGC
TGGTCATCTTCGAGATGGTTCACCTCAAGGAACTCGGCCTCTACAACCTGATGAACATCACCCGGGGTTCTGTCCGCATCGAGAAGAACAATGAGCTCTG
TTACTTGGCCACTATCGACTGGTCCCGTATCCTGGATTCCGTGGAGGATAATTACATCGTGTTGAACAAAGATGACAACGAGGAGTGTGGAGACATCTGT
CCGGGTACCGCGAAGGGCAAGACCAACTGCCCCGCCACCGTCATCAACGGGCAGTTTGTCGAACGATGTTGGACTCATAGTCACTGCCAGAAAGTTTGCC
CGACCATCTGTAAGTCACACGGCTGCACCGCCGAAGGCCTCTGTTGCCACAGCGAGTGCCTGGGCAACTGTTCTCAGCCCGACGACCCCACCAAGTGCGT
GGCCTGCCGCAACTTCTACCTGGACGGCAGGTGTGTGGAGACCTGCCCGCCCCCGTACTACCACTTCCAGGACTGGCGCTGTGTGAACTTCAGCTTCTGC
CAGGACCTGCACCACAAATGCAAGAACTCGCGGAGGCAGGGCTGCCACCAGTACGTCATTCACAACAACAAGTGCATCCCTGAGTGTCCCTCCGGGTACA
CGATGAATTCCAGCAACTTGCTGTGCACCCCATGCCTGGGTCCCTGTCCCAAGGTGTGCCACCTCCTAGAAGGCGAGAAGACCATCGACTCGGTGACGTC
TGCCCAGGAGCTCCGAGGATGCACCGTCATCAACGGGAGTCTGATCATCAACATTCGAGGAGGCAACAATCTGGCAGCTGAGCTAGAAGCCAACCTCGGC
CTCATTGAAGAAATTTCAGGGTATCTAAAAATCCGCCGATCCTACGCTCTGGTGTCACTTTCCTTCTTCCGGAAGTTACGTCTGATTCGAGGAGAGACCT
TGGAAATTGGGAACTACTCCTTCTATGCCTTGGACAACCAGAACCTAAGGCAGCTCTGGGACTGGAGCAAACACAACCTCACCATCACTCAGGGGAAACT
CTTCTTCCACTATAACCCCAAACTCTGCTTGTCAGAAATCCACAAGATGGAAGAAGTTTCAGGAACCAAGGGGCGCCAGGAGAGAAACGACATTGCCCTG
AAGACCAATGGGGACCAGGCATCCTGTGAAAATGAGTTACTTAAATTTTCTTACATTCGGACATCTTTTGACAAGATCTTGCTGAGATGGGAGCCGTACT
GGCCCCCCGACTTCCGAGACCTCTTGGGGTTCATGCTGTTCTACAAAGAGGCCCCTTATCAGAATGTGACGGAGTTCGACGGGCAGGATGCGTGTGGTTC
CAACAGTTGGACGGTGGTAGACATTGACCCACCCCTGAGGTCCAACGACCCCAAATCACAGAACCACCCAGGGTGGCTGATGCGGGGTCTCAAGCCCTGG
ACCCAGTATGCCATCTTTGTGAAGACCCTGGTCACCTTTTCGGATGAACGCCGGACCTATGGGGCCAAGAGTGACATCATTTATGTCCAGACAGATGCCA
CCAACCCCTCTGTGCCCCTGGATCCAATCTCAGTGTCTAACTCATCATCCCAGATTATTCTGAAGTGGAAACCACCCTCCGACCCCAATGGCAACATCAC
CCACTACCTGGTTTTCTGGGAGAGGCAGGCGGAAGACAGTGAGCTGTTCGAGCTGGATTATTGCCTCAAAGGGCTGAAGCTGCCCTCGAGGACCTGGTCT
CCACCATTCGAGTCTGAAGATTCTCAGAAGCACAACCAGAGTGAGTATGAGGATTCGGCCGGCGAATGCTGCTCCTGTCCAAAGACAGACTCTCAGATCC
TGAAGGAGCTGGAGGAGTCCTCGTTTAGGAAGACGTTTGAGGATTACCTGCACAACGTGGTTTTCGTCCCCAGGCCATCTCGGAAACGCAGGTCCCTTGG
CGATGTTGGGAATGTGACGGTGGCCGTGCCCACGGTGGCAGCTTTCCCCAACACTTCCTCGACCAGCGTGCCCACGAGTCCGGAGGAGCACAGGCCTTTT
GAGAAGGTGGTGAACAAGGAGTCGCTGGTCATCTCCGGCTTGCGACACTTCACGGGCTATCGCATCGAGCTGCAGGCTTGCAACCAGGACACCCCTGAGG
AACGGTGCAGTGTGGCAGCCTACGTCAGTGCGAGGACCATGCCTGAAGCCAAGGCTGATGACATTGTTGGCCCTGTGACGCATGAAATCTTTGAGAACAA
CGTCGTCCACTTGATGTGGCAGGAGCCGAAGGAGCCCAATGGTCTGATCGTGCTGTATGAAGTGAGTTATCGGCGATATGGTGATGAGGAGCTGCATCTC
TGCGTCTCCCGCAAGCACTTCGCTCTGGAACGGGGCTGCAGGCTGCGTGGGCTGTCACCGGGGAACTACAGCGTGCGAATCCGGGCCACCTCCCTTGCGG
GCAACGGCTCTTGGACGGAACCCACCTATTTCTACGTGACAGACTATTTAGACGTCCCGTCAAATATTGCAAAAATTATCATCGGCCCCCTCATCTTTGT
CTTTCTCTTCAGTGTTGTGATTGGAAGTATTTATCTATTCCTGAGAAAGAGGCAGCCAGATGGGCCGCTGGGACCGCTTTACGCTTCTTCAAACCCTGAG
TATCTCAGTGCCAGTGATGTGTTTCCATGCTCTGTGTACGTGCCGGACGAGTGGGAGGTGTCTCGAGAGAAGATCACCCTCCTTCGAGAGCTGGGGCAGG
GCTCCTTCGGCATGGTGTATGAGGGCAATGCCAGGGACATCATCAAGGGTGAGGCAGAGACCCGCGTGGCGGTGAAGACGGTCAACGAGTCAGCCAGTCT
CCGAGAGCGGATTGAGTTCCTCAATGAGGCCTCGGTCATGAAGGGCTTCACCTGCCATCACGTGGTGCGCCTCCTGGGAGTGGTGTCCAAGGGCCAGCCC
ACGCTGGTGGTGATGGAGCTGATGGCTCACGGAGACCTGAAGAGCTACCTCCGTTCTCTGCGGCCAGAGGCTGAGAATAATCCTGGCCGCCCTCCCCCTA
CCCTTCAAGAGATGATTCAGATGGCGGCAGAGATTGCTGACGGGATGGCCTACCTGAACGCCAAGAAGTTTGTGCATCGGGACCTGGCAGCGAGAAACTG
CATGGTCGCCCATGATTTTACTGTCAAAATTGGAGACTTTGGAATGACCAGAGACATCTATGAAACGGATTACTACCGGAAAGGGGGCAAGGGTCTGCTC
CCTGTACGGTGGATGGCACCGGAGTCCCTGAAGGATGGGGTCTTCACCACTTCTTCTGACATGTGGTCCTTTGGCGTGGTCCTTTGGGAAATCACCAGCT
TGGCAGAACAGCCTTACCAAGGCCTGTCTAATGAACAGGTGTTGAAATTTGTCATGGATGGAGGGTATCTGGATCAACCCGACAACTGTCCAGAGAGAGT
CACTGACCTCATGCGCATGTGCTGGCAATTCAACCCCAAGATGAGGCCAACCTTCCTGGAGATTGTCAACCTGCTCAAGGACGACCTGCACCCCAGCTTT
CCAGAGGTGTCGTTCTTCCACAGCGAGGAGAACAAGGCTCCCGAGAGTGAGGAGCTGGAGATGGAGTTTGAGGACATGGAGAATGTGCCCCTGGACCGTT
CCTCGCACTGTCAGAGGGAGGAGGCGGGGGGCCGGGATGGAGGGTCCTCGCTGGGTTTCAAGCGGAGCTACGAGGAACACATCCCTTACACACACATGAA
CGGAGGCAAGAAAAACGGGCGGATTCTGACCTTGCCTCGGTCCAATCCTTCCTAACAGTGCCTACCGTGGCGGGGGCGGGCAGGGGTTCCCATTTTCGCT
TTCCTCTGGTTTGAAAGCCTCTGGAAAACTCAGGATTCTCACGACTCTACCATGTCCAATGGAGTTCAGAGATCGTTCCTATACATTTCTGTTCATCTTA
AGGTGGACTCGTTTGGTTACCAATTTAACTAGTCCTGCAGAGGATTTAACTGTGAACCTGGAGGGCAAGGGGTTTCCACAGTTGCTGCTCCTTTGGGGCA
ACGACGGTTTCAAACCAGGATTTTGTGTTTTTTCGTTCCCCCCACCCGCCCCCAGCAGATGGAAAGAAAGCACCTGTTTTTACAAATTCTTTTTTTTTTT
TTTTTTTTTTGCTGGTGTCTGAGCTTCAGTATAAAAGACAAAACTTCCTGTTTGTGGAACAAAAGTTCGAAAGAAAAAACAAAACAAAAACACCCAGCCC
TGTTCCAGGAGAATTTCAAGTTTTACAGGTTGAGCTTCAAGATGGTTTTTTTGGTTTTTTTTTTTTCTCTCATCCAGGCTGAAGGATTTTTTTTTTCTTT
ACAAAATGAGTTCCTCAAATTGACCAATAGCTGCTGCTTTCATATTTTGGATAAGGGTCTGTGGTCCCGGCGTGTGCTCACGTGTGTATGCACGTGTGTG
TGTCCATTAGACACGGCTGATGTGTGTGCAAAGTATCCATGCGGAGTTGATGCTTTGGGAATTGGCTCATGAAGGTTCTTCTCAAGGGTGCGAGCTCATC
CCCCTCTCTCCTTCCTTCTTATTGACTGGGAGACTGTGCTCTCGACAGATTCTTCTTGTGTCAGAAGTCTAGCCTCAGGTTTCTACCCTCCCTTCACATT
GGTGGCCAAGGGAGGAGCATTTCATTTGGAGTGATTATGAATCTTTTCAAGACCAAACCAAGCTAGGACATTAAAAAAAAAAAAAGAAAAAGAAAGAAAA
AACAAAATGGAAAAAGGAAAAAAAAAAAGAACTGAGATGACAGAGTTTTGAGAATATATTTGTACCATATTTAATTTTTAAAGTCTCTGGTATTAGCCTC
ATAAGTTATTGACTATTCCCCGGGGTTGGCGGGGAGTGGGGACATGAGTTGGTCTGCCTGTTGTGGGGCCGGGAAGGGGAGGGAGTCAGGCACAAGTGGC
CTCTTTGTTTGGTCTTAAAGGCATCCATTTCTGGGAATGAAGCCATGTTCGCTGCTAACACTTTTGGATGTTGTGAGGCCACGTGGAGTGTGTGAGAGAC
TAGGTTTTATGGATGGTCTGGTTCAGGTACCAGGTCTGCTGGAAGGTTCCTGTTCGGATAAGCTGGTAGCTACCTAGCTCTGAGCCTGCCTTCAAGAACA
CCTGTGTTCATCCTCTGATTCTCTGTGTGTACCTCTTGTGGCGTTTCCTCTCCCGGGTGTGAACATCCTAACCGTTATTGTGCAAACCCAAGAACGTCAG
ATCCCAAAGCACAACAACCTGGATGGACTTTGGGAACATCTAAGCAATGTAAGAGAGAGGTGCACTGAGAGTACGTCTTGGTCCCCTCCACCCTGAGAGC
ATCTGACGGTCCTCAGTACTGAACTCCCGGAAGCTGCTCTGAGCCCGGTGACCTCATCTGGGCCAGGTGTGGTGCCTGAGCTGAATGCTCAGGTGCTTAC
AGTGTTGCAATCCCTAAGAGAGTAGAGTCTGGAGGAGAAACCGTGAAAAAGACCTTACACACCACCAAGAACTTCCGAATGGGCGTGAATCCACCGTTTC
TTCTCTTTGCAAAAAGAACCACCACAGCTGCTCAAAGAACACAGTGAACTCATCACTTTGGTTCATCAAAAAATCATCGCCCATGCGTTATTCCTGAGTG
CATTTTCTTACAACTTTTTGACTGCTTCCTTTTCTTCTTCTCTTAAGAGTTGTGGGCTTAAGAATGGGATAGAGTCATAATGGCAACCTCCAAGCCCTCT
CAATTCTTGATTAAGAACACAGGTAGACATGAATCCCAATTGTCTATTGCTATCTTATTTATATGATTCGGGAAAATACAGCATGTAAAAATATTGCTGA
GGAGCCTCAGTGATTGGGTACAAGAAGCAAGAGTACAGAAATTATTTTTGCCAAATTTATTTTGTAAATATGAGGGTCTGTACCTAAATTTAAAAAAAAA
ACACGTAGAACTAGGTATTTTGTTCTCTTCTTAGTAAATTTGTAGTGGTTGTATACTACACTAGCTGCAATTTTCACATTTTTCTAATTCAGAAAGGTTT
TTCTTATATTAGGGGAAAAAGTATTTATTTTAATATATAAAATCACTCTGAAAATCACTCTCATAAAAAATGGAGCGCATGTAAATTTTTATCAAAGAAA
AATAAACAGGTGAATGGGGGATAGTGATTTTCTTTTTTCAGCACAGTCTACCTCAGTGTATTGTTAAGATGTGATTCAATCATGGACATCTTTGAGATTT
CAGAATTCTACCTGGAACCGGTCTGAATCAGGGAACGTGTGTATCAGCTGATTCGAATGCCAGGGACCAGTAAGAATTTTGAGGGAGGGAGTTGGGATGG
AGAAGGTATGGCCTTTATGCGAGCATAGATCCTTTTCTTCCTGGCTGGTAATATTCTTCTCTGAATTTAATCTTCCTTTAAAAAAAAATCCTCCATCTAT
TGTCACTATGTTCCCCAAACATAAACTAAGTTCCAGGCTGTCATGATGTATCTGATATATGGGGTAACCCAGCAAGGTGTACCTTCCTTTGGTGAGAGAT
GGCTGCCGGGGCAAAGACGGGCTTTGATTCAGAGCAAGCATTCCCACCTGTTCCATGGAATCCCCCTGAAGTGAGCACAAAGGTGCCCTGGGCTCCCTGA
TGGTTTATGCCCACTCCTTTCAGGCTGGTGATGCACCTTACACACAAACACCTAATGCAATGTCTTTTTAAATTCTCCAAGTGGGATGGGAGCATGTGAG
GGAAATTCCAATCCAAAACCCATTAATGTGCTGAACGCTTTTTTTTTTTTTTTTTTTTTTTTTGCAACAACACCTTGGACCTCTGTGTTGGGGTTTGACT
GACCTCAAGCTGATATTATTGGACCTTGTGCAGCTTTGATAACCCATGTGAGAGTCTAGGCAGGACCAGTGGGGCCCAAATCTTGCTGCTCTTGTACTTT
TAGGCACTGCCCTTGCAGACTCACCTTTCTCCACCTGCCCTGGAGAAAGGTAGGGTGTGCTGGGCCTGCCCCTTGCAAATGGGATTCACCAGTTTCATTT
ATTTGACTCTACTGCCACAGTGAAAAGAGCAAACAGCTATTGGGTTGCAAACCTCCTTTGACATTAGGAAATGTTGACTTTGTAACAATAAAACTTTGGT
CCTAGAAAGACACGGTTGTCCTGGGAGTTTGTAGTGTTAAGTTGCAACAACAACAACAAAAAGCAACAAAACCAGCTTAGGATAACACTTTTTGTTGCTT
GTTCTTAAAGATGTCTCACTATGATTAAAACCCTTTTCATTAATGTAGTGAAAGCCACACAGGAGTTCCTTCTTCCAGGAGGAGAATACCAAGCACATCA
CTTTCTCTCTGCATCAGTGATGTCAAATACGCATCAGAAAATGTTCAGGTTTTAGGAGCTGTCCTAGGTGCTGTTTCATCATTGGAAGCAGTGAGAAAGA
GAAGCACTGCTGCTTGTCTGGATATAGGCTGAGGATGATTGAGAGAAGCTGTGGGAACTGACACAAGGGTCTGCATAGGTCATCCTGTGACCCTGGGGAC
TATGTTACCAACTGACAGACAGATCTTTCACTGTATCCTAGCAGGGCAGGTAGTCCACCAAGAAATGTGCTTATTGGATTGGGAGGTGTTTATTTGTAGT
CTGCTGTAACACGTGTGAAAGAGCAGGAGCGTCATCAGCATATGACTTGCGCTGGTCATCCGGTAAATGGATGTGCTGTAGTCCCAGTGCTAATCATTTC
TCTCCTTCACAGTGGGTGGAAGTTTAGGGTTAAATGTCCTTTGAATGTCACCTGGTGAGTCCTTGACACCTTAGGCTCTTCAGAAACAATGGTTTTGTTG
AGGATGGGGAACAGGGAATGCCGATTTTATATACATGGTACACAGAGAGGGGTGTCACTTCAGAAAATCTTCCAGCATGTTCTTCAGAATATTAATTTAT
ATGCGAGGTGAGGTTGGGAATGAAAAGAACAGGTCAGCACTTTTTTTTTTCCTAGAACATACAAAAGAACATGGTGGACTTTCAGGGAGTGCAATGGAAG
GTGAATATTTCCTTAAGGGTCCCCGAGAAATGGGAGTGAGGGGAGGGGACACAATGGCTTTTTGAGCTTACTTTTACCTTCTGATACTAGTCAAGGTCCA
GAACCAGCCACCAGCCAAATTTCTATCTGGGTGCGGGCCACTGAAAATCCTTGTTAAAAACCAGATCACAAATCTGGGGCTCTTGGTCCCATTGGAGAAG
GAAGGAAGAGCCTCAAAATAAGTGTGCACCCATGCACATATTCAGGAACAGCTTGTTTAGTCTTTACACTTTGCCTGAAAGTTGCTTCTCCTCGTCCCTT
TGTGTGCCTGGGTGGCCTCGGCCCTGTGCGTTGGCAACGCAGGATCAAATGTGCTGCAGCTTTTGCAGAAAACAACTCAGAAACACAAAACCCCCCAACA
GCTCAATTATTATTTTTTCAATGTTTTCCTACAAGAGCCAAGTAGCACCATGTACAGAAGACGCCTTTTTTTTTGGAATATTGAAATCGTTCTGCATGTA
AAATATGGGATAATGACCTGTTTATATTAAAATTCTGATTAAATTATCTGAGAATA
- INSR.u.f.13 (forward primer)
- INSR.u.r.17 (reverse primer)
- Single exon skipping
Frame 0
SRRPPATRQPRCPPASQLVRRSARPSVPEPADRDPERAGPRAERQSRAQRGAPGPEILGRGPGRSGR
GVGATTARASAQYL*LAKPRAPFPGLPLGPPRQ
GGCGPRVAGVEEKDARPPAPLGWPPRSMTPAGQ
RRAL*SEETPRSRSHGHRGPAGGGGRAAAGGGGR
AATGRRGPPVPRRGVSRHGYPEQPH*VA*AGEL
LCHRRTLADTLDVQNEARRFPRPQFPQTHHDH*
LLAALPGLWAREPEGPVPQPHGHPGITTVL*LRA
GHLRDGSPQGTRPLQPDEHHPGFCPHREEQ*AL
LLGHYRLVPYPGFRGG*LHRVEQR*QRGVWRHL
SGYREGQDQLPRHRHQRAVCRTMLDS*SLPESLP
DHL*VTRLHRRRPLLPQRVPGQLFSARRPHQVR
GLPQLLPGRQVCGDLPAPVLPLPGLALCELQLL
PGPAPQMQELAEAGLPPVRHSQQQVHP*VSLRVH
DEFQQLAVHPMPGSLSQGVPPPRRREDHRLGDV
CPGAPRMHRHQRESDHQHSRRQQSGS*ARSQPR
PH*RNFRVSKNPPILRSGVTFLLPEVTSDSRRDL
GNWELLLLCLGQPEPKAALGLEQTQPHHHSGET
LLPL*PQTLLVRNPQDGRSFRNQGAPGEKRHCP
EDQWGPGIL*K*VT*IFLHSDIF*QDLAEMGAVL
APRLPRPLGVHAVLQRGPLSECDGVRRAGCVWF
QQLDGGRH*PTPEVQRPQITEPPRVADAGSQAL
DPVCHLCEDPGHLFG*TPDLWGQE*HHLCPDRCH
QPLCAPGSNLSV*LIIPDYSEVETTLRPQWQHH
PLPGFLGEAGGRQ*AVRAGLLPQRAEAALEDLV
STIRV*RFSEAQPE*V*GFGRRMLLLSKDRLSDP
EGAGGVLV*EDV*GLPAQRGFRPQAISETQVPW
RCWECDGGRAHGGSFPQHFLDQRAHESGGAQAF
*EGGEQGVAGHLRLATLHGLSHRAAGLQPGHP*G
TVQCGSLRQCEDHA*SQG**HCWPCDA*NL*EQ
RRPLDVAGAEGAQWSDRAV*SELSAIW**GAAS
LRLPQALRSGTGLQAAWAVTGELQRANPGHLPCG
QRLLDGTHLFLRDRLFRRPVKYCKNYHRPPHLC
LSLQCCDWKYLSIPEKEAARWAAGTALRFFKP*
VSQCQ*CVSMLCVRAGRVGGVSREDHPPSRAGAG
LLRHGV*GQCQGHHQG*GRDPRGGEDGQRVSQS
PRAD*VPQ*GLGHEGLHLPSRGAPPGSGVQGPA
HAGGDGADGSRRPEELPPFSAARG*E*SWPPSPY
PSRDDSDGGRDC*RDGLPERQEVCASGPGSEKL
HGRP*FYCQNWRLWNDQRHL*NGLLPERGQGSA
PCTVDGTGVPEGWGLHHFF*HVVLWRGPLGNHQL
GRTALPRPV**TGVEICHGWRVSGSTRQLSRES
H*PHAHVLAIQPQDEANLPGDCQPAQGRPAPQL
SRGVVLPQRGEQGSRE*GAGDGV*GHGECAPGPF
LALSEGGGGGPGWRVLAGFQAELRGTHPLHTHE
RRQEKRADSDLASVQSFLTVPTVAGAGRGSHFR
FPLV*KPLENSGFSRLYHVQWSSEIVPIHFCSS*
GGLVWLPI*LVLQRI*L*TWRARGFHSCCSFGA
TTVSNQDFVFFRSPHPPPADGKKAPVFTNSFFF
FFFLLVSELQYKRQNFLFVEQKFERKNKTKTPSP
VPGEFQVLQVELQDGFFGFFFFSHPG*RIFFFF
TK*VPQIDQ*LLLSYFG*GSVVPACAHVCMHVC
VSIRHG*CVCKVSMRS*CFGNWLMKVLLKGASSS
PSLLPSY*LGDCALDRFFLCQKSSLRFLPSLHI
GGQGRSISFGVIMNLFKTKPS*DIKKKKRKRKK
KQNGKRKKKKN*DDRVLRIYLYHI*FLKSLVLAS
*VIDYSPGLAGSGDMSWSACCGAGKGRESGTSG
LFVWS*RHPFLGMKPCSLLTLLDVVRPRGVCER
LGFMDGLVQVPGLLEGSCSDKLVAT*L*ACLQEH
LCSSSDSLCVPLVAFPLPGVNILTVIVQTQERQ
IPKHNNLDGLWEHLSNVRERCTESTSWSPPP*E
HLTVLSTELPEAALSPVTSSGPGVVPELNAQVLT
VLQSLRE*SLEEKP*KRPYTPPRTSEWA*IHRF
FSLQKEPPQLLKEHSELITLVHQKIIAHALFLS
AFSYNFLTASFSSSLKSCGLKNGIES*WQPPSPL
NS*LRTQVDMNPNCLLLSYLYDSGKYSM*KYC*
GASVIGYKKQEYRNYFCQIYFVNMRVCT*I*KK
NT*N*VFCSLLSKFVVVVYYTSCNFHIFLIQKGF
SYIRGKSIYFNI*NHSENHSHKKWSACKFLSKK
NKQVNGG**FSFFSTVYLSVLLRCDSIMDIFEI
SEFYLEPV*IRERVYQLIRMPGTSKNFEGGSWDG
EGMAFMRA*ILFFLAGNILL*I*SSFKKKSSIY
CHYVPQT*TKFQAVMMYLIYGVTQQGVPSFGER
WLPGQRRALIQSKHSHLFHGIPLK*AQRCPGLPD
GLCPLLSGW*CTLHTNT*CNVFLNSPSGMGACE
GNSNPKPINVLNAFFFFFFFFATTPWTSVLGFD
*PQADIIGPCAALITHVRV*AGPVGPKSCCSCTF
RHCPCRLTFLHLPWRKVGCAGPAPCKWDSPVSF
I*LYCHSEKSKQLLGCKPPLTLGNVDFVTIKLW
S*KDTVVLGVCSVKLQQQQQKATKPA*DNTFCCL
FLKMSHYD*NPFH*CSESHTGVPSSRRRIPSTS
LSLCISDVKYASENVQVLGAVLGAVSSLEAVRK
RSTAACLDIG*G*LREAVGTDTRVCIGHPVTLGT
MLPTDRQIFHCILAGQVVHQEMCLLDWEVFICS
LL*HV*KSRSVISI*LALVIR*MDVL*SQC*SF
LSFTVGGSLGLNVL*MSPGESLTP*ALQKQWFC*
GWGTGNADFIYMVHREGCHFRKSSSMFFRILIY
MRGEVGNEKNRSALFFFLEHTKEHGGLSGSAME
GEYFLKGPREMGVRGGDTMAF*AYFYLLILVKVQ
NQPPAKFLSGCGPLKILVKNQITNLGLLVPLEK
EGRASK*VCTHAHIQEQLV*SLHFA*KLLLLVP
LCAWVASALCVGNAGSNVLQLLQKTTQKHKTPQQ
LNYYFFNVFLQEPSSTMYRRRLFFWNIEIVLHV
KYGIMTCLY*NSD*II*E
Frame 1
PAARPPPASPGARPPVS*SVGPRVPLSRSPQIATQSARGREPRDSPGRSAELRAPRSWDGARAAAA
GGSGPPPQGPPLSICSWRSRARPSRGCLWALPGR
GAAARGSRAWKRRTRGPQRLLGGRLGA*PPRAS
AARSDPRRPRAPAAMATGGRRGAAAAPLLVAVA
ALLLGAAGHLYPGEVCPGMDIRNNLTRLHELENC
SVIEGHLQILLMFKTRPEDFRDLSFPKLIMITD
YLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYA
LVIFEMVHLKELGLYNLMNITRGSVRIEKNNELC
YLATIDWSRILDSVEDNYIVLNKDDNEECGDIC
PGTAKGKTNCPATVINGQFVERCWTHSHCQKVC
PTICKSHGCTAEGLCCHSECLGNCSQPDDPTKCV
ACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFC
QDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGY
TMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTS
AQELRGCTVINGSLIINIRGGNNLAAELEANLG
LIEEISGYLKIRRSYALVSLSFFRKLRLIRGET
LEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKL
FFHYNPKLCLSEIHKMEEVSGTKGRQERNDIAL
KTNGDQASCENELLKFSYIRTSFDKILLRWEPY
WPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGS
NSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPW
TQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDA
TNPSVPLDPISVSNSSSQIILKWKPPSDPNGNIT
HYLVFWERQAEDSELFELDYCLKGLKLPSRTWS
PPFESEDSQKHNQSEYEDSAGECCSCPKTDSQI
LKELEESSFRKTFEDYLHNVVFVPRPSRKRRSLG
DVGNVTVAVPTVAAFPNTSSTSVPTSPEEHRPF
EKVVNKESLVISGLRHFTGYRIELQACNQDTPE
ERCSVAAYVSARTMPEAKADDIVGPVTHEIFENN
VVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHL
CVSRKHFALERGCRLRGLSPGNYSVRIRATSLA
GNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFV
FLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPE
YLSASDVFPCSVYVPDEWEVSREKITLLRELGQ
GSFGMVYEGNARDIIKGEAETRVAVKTVNESASL
RERIEFLNEASVMKGFTCHHVVRLLGVVSKGQP
TLVVMELMAHGDLKSYLRSLRPEAENNPGRPPP
TLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNC
MVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLL
PVRWMAPESLKDGVFTTSSDMWSFGVVLWEITS
LAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERV
TDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSF
PEVSFFHSEENKAPESEELEMEFEDMENVPLDR
SSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMN
GGKKNGRILTLPRSNPS*QCLPWRGRAGVPIFA
FLWFESLWKTQDSHDSTMSNGVQRSFLYISVHL
KVDSFGYQFN*SCRGFNCEPGGQGVSTVAAPLGQ
RRFQTRILCFFVPPTRPQQMERKHLFLQILFFF
FFFCWCLSFSIKDKTSCLWNKSSKEKTKQKHPA
LFQENFKFYRLSFKMVFLVFFFSLIQAEGFFFSL
QNEFLKLTNSCCFHILDKGLWSRRVLTCVCTCV
CPLDTADVCAKYPCGVDALGIGS*RFFSRVRAH
PPLSFLLIDWETVLSTDSSCVRSLASGFYPPFTL
VAKGGAFHLE*L*IFSRPNQARTLKKKKEKERK
NKMEKGKKKRTEMTEF*EYICTIFNF*SLWY*P
HKLLTIPRGWRGVGT*VGLPVVGPGRGGSQAQVA
SLFGLKGIHFWE*SHVRC*HFWML*GHVECVRD
*VLWMVWFRYQVCWKVPVRISW*LPSSEPAFKN
TCVHPLILCVYLLWRFLSRV*TS*PLLCKPKNVR
SQSTTTWMDFGNI*AM*ERGALRVRLGPLHPES
I*RSSVLNSRKLL*AR*PHLGQVWCLS*MLRCL
QCCNP*ESRVWRRNREKDLTHHQELPNGRESTVS
SLCKKNHHSCSKNTVNSSLWFIKKSSPMRYS*V
HFLTTF*LLPFLLLLRVVGLRMG*SHNGNLQAL
SILD*EHR*T*IPIVYCYLIYMIRENTACKNIAE
EPQ*LGTRSKSTEIIFAKFIL*I*GSVPKFKKK
TRRTRYFVLFLVNL*WLYTTLAAIFTFF*FRKV
FLILGEKVFILIYKITLKITLIKNGAHVNFYQRK
INR*MGDSDFLFSAQSTSVYC*DVIQSWTSLRF
QNSTWNRSESGNVCIS*FECQGPVRILREGVGM
EKVWPLCEHRSFSSWLVIFFSEFNLPLKKNPPSI
VTMFPKHKLSSRLS*CI*YMG*PSKVYLPLVRD
GCRGKDGL*FRASIPTCSMESP*SEHKGALGSL
MVYAHSFQAGDAPYTQTPNAMSF*ILQVGWEHVR
EIPIQNPLMC*TLFFFFFFFLQQHLGPLCWGLT
DLKLILLDLVQL**PM*ESRQDQWGPNLAALVL
LGTALADSPFSTCPGER*GVLGLPLANGIHQFHL
FDSTATVKRANSYWVANLL*H*EMLTL*Q*NFG
PRKTRLSWEFVVLSCNNNNKKQQNQLRITLFVA
CS*RCLTMIKTLFINVVKATQEFLLPGGEYQAHH
FLSASVMSNTHQKMFRF*ELS*VLFHHWKQ*ER
EALLLVWI*AEDD*EKLWELTQGSA*VIL*PWG
LCYQLTDRSFTVS*QGR*STKKCAYWIGRCLFVV
CCNTCERAGASSAYDLRWSSGKWMCCSPSANHF
SPSQWVEV*G*MSFECHLVSP*HLRLFRNNGFV
EDGEQGMPILYTWYTERGVTSENLPACSSEY*FI
CEVRLGMKRTGQHFFFS*NIQKNMVDFQGVQWK
VNISLRVPEKWE*GEGTQWLFELTFTF*Y*SRS
RTSHQPNFYLGAGH*KSLLKTRSQIWGSWSHWRR
KEEPQNKCAPMHIFRNSLFSLYTLPESCFSSSL
CVPGWPRPCALATQDQMCCSFCRKQLRNTKPPN
SSIIIFSMFSYKSQVAPCTEDAFFFGILKSFCM*
NMG**PVYIKILIKLSEN
Frame 2
PPPARHPPAQVPARQSASPSVRASLCPGARRSRPRARGAESRETVPGAARSSGPRDPGTGPGPQRP
GGRGHHRKGLRSVFVAGEAARALPGAASGPSPA
GGLRPAGRGRGREGRAAPSASWVAASEHDPRGPA
PRALIRGDPALPQPWPPGAGGGRRPRRCWWRWP
RCYWAPRATCTPERCVPAWISGTTSLGCMSWRI
ALSSKDTCRYS*CSKRGPKISETSVSPNSS*SLI
TCCSSGSMGSRA*RTCSPTSRSSGDHDCSLTTR
WSSSRWFTSRNSASTT**TSPGVLSASRRTMSS
VTWPLSTGPVSWIPWRIITSC*TKMTTRSVETSV
RVPRRARPTAPPPSSTGSLSNDVGLIVTARKFA
RPSVSHTAAPPKASVATASAWATVLSPTTPPSA
WPAATSTWTAGVWRPARPRTTTSRTGAV*TSASA
RTCTTNARTRGGRAATSTSFTTTSASLSVPPGT
R*IPATCCAPHAWVPVPRCATS*KARRPSTR*R
LPRSSEDAPSSTGV*SSTFEEATIWQLS*KPTSA
SLKKFQGI*KSADPTLWCHFPSSGSYV*FEERP
WKLGTTPSMPWTTRT*GSSGTGANTTSPSLRGN
SSSTITPNSACQKSTRWKKFQEPRGARRETTLP*
RPMGTRHPVKMSYLNFLTFGHLLTRSC*DGSRT
GPPTSETSWGSCCSTKRPLIRM*RSSTGRMRVV
PTVGRW*TLTHP*GPTTPNHRTTQGG*CGVSSPG
PSMPSL*RPWSPFRMNAGPMGPRVTSFMSRQMP
PTPLCPWIQSQCLTHHPRLF*SGNHPPTPMATS
PTTWFSGRGRRKTVSCSSWIIASKG*SCPRGPGL
HHSSLKILRSTTRVSMRIRPANAAPVQRQTLRS
*RSWRSPRLGRRLRITCTTWFSSPGHLGNAGPL
AMLGM*RWPCPRWQLSPTLPRPACPRVRRSTGLL
RRW*TRSRWSSPACDTSRAIASSCRLATRTPLR
NGAVWQPTSVRGPCLKPRLMTLLAL*RMKSLRT
TSST*CGRSRRSPMV*SCCMK*VIGDMVMRSCIS
ASPASTSLWNGAAGCVGCHRGTTACESGPPPLR
ATALGRNPPIST*QTI*TSRQILQKLSSAPSSL
SFSSVL*LEVFIYS*ERGSQMGRWDRFTLLQTLS
ISVPVMCFHALCTCRTSGRCLERRSPSFESWGR
APSAWCMRAMPGTSSRVRQRPAWR*RRSTSQPV
SESGLSSSMRPRS*RASPAITWCASWEWCPRASP
RWW*WS*WLTET*RATSVLCGQRLRIILAALPL
PFKR*FRWRQRLLTGWPT*TPRSLCIGTWQRET
AWSPMILLSKLETLE*PETSMKRITTGKGARVCS
LYGGWHRSP*RMGSSPLLLTCGPLAWSFGKSPA
WQNSLTKACLMNRC*NLSWMEGIWINPTTVQRE
SLTSCACAGNSTPR*GQPSWRLSTCSRTTCTPAF
QRCRSSTARRTRLPRVRSWRWSLRTWRMCPWTV
PRTVRGRRRGAGMEGPRWVSSGATRNTSLTHT*
TEARKTGGF*PCLGPILPNSAYRGGGGQGFPFSL
SSGLKASGKLRILTTLPCPMEFRDRSYTFLFIL
RWTRLVTNLTSPAEDLTVNLEGKGFPQLLLLWG
NDGFKPGFCVFSFPPPAPSRWKESTCFYKFFFFF
FFFAGV*ASV*KTKLPVCGTKVRKKKQNKNTQP
CSRRISSFTG*ASRWFFWFFFFLSSRLKDFFFL
YKMSSSN*PIAAAFIFWIRVCGPGVCSRVYARVC
VH*TRLMCVQSIHAELMLWELAHEGSSQGCELI
PLSPSFLLTGRLCSRQILLVSEV*PQVSTLPSH
WWPREEHFIWSDYESFQDQTKLGH*KKKKKKKEK
TKWKKEKKKELR*QSFENIFVPYLIFKVSGISL
ISY*LFPGVGGEWGHELVCLLWGREGEGVRHKW
PLCLVLKASISGNEAMFAANTFGCCEATWSV*ET
RFYGWSGSGTRSAGRFLFG*AGSYLALSLPSRT
PVFIL*FSVCTSCGVSSPGCEHPNRYCANPRTS
DPKAQQPGWTLGTSKQCKREVH*EYVLVPSTLRA
SDGPQY*TPGSCSEPGDLIWARCGA*AECSGAY
SVAIPKRVESGGETVKKTLHTTKNFRMGVNPPF
LLFAKRTTTAAQRTQ*THHFGSSKNHRPCVIPEC
IFLQLFDCFLFFFS*ELWA*EWDRVIMATSKPS
QFLIKNTGRHESQLSIAILFI*FGKIQHVKILL
RSLSDWVQEARVQKLFLPNLFCKYEGLYLNLKKK
HVELGILFSS**ICSGCILH*LQFSHFSNSERF
FLY*GKKYLF*YIKSL*KSLS*KMERM*IFIKE
K*TGEWGIVIFFFQHSLPQCIVKM*FNHGHL*DF
RILPGTGLNQGTCVSADSNARDQ*EF*GRELGW
RRYGLYASIDPFLPGW*YSSLNLIFL*KKILHL
LSLCSPNIN*VPGCHDVSDIWGNPARCTFLW*EM
AAGAKTGFDSEQAFPPVPWNPPEVSTKVPWAP*
WFMPTPFRLVMHLTHKHLMQCLFKFSKWDGSM*
GKFQSKTH*CAERFFFFFFFFCNNTLDLCVGV*L
TSS*YYWTLCSFDNPCESLGRTSGAQILLLLYF
*ALPLQTHLSPPALEKGRVCWACPLQMGFTSFI
YLTLLPQ*KEQTAIGLQTSFDIRKC*LCNNKTLV
LERHGCPGSL*C*VATTTTKSNKTSLG*HFLLL
VLKDVSL*LKPFSLM**KPHRSSFFQEENTKHI
TFSLHQ*CQIRIRKCSGFRSCPRCCFIIGSSEKE
KHCCLSGYRLRMIERSCGN*HKGLHRSSCDPGD
YVTN*QTDLSLYPSRAGSPPRNVLIGLGGVYL*
SAVTRVKEQERHQHMTCAGHPVNGCAVVPVLIIS
LLHSGWKFRVKCPLNVTW*VLDTLGSSETMVLL
RMGNRECRFYIHGTQRGVSLQKIFQHVLQNINL
YAR*GWE*KEQVSTFFFPRTYKRTWWTFRECNGR
*IFP*GSPRNGSEGRGHNGFLSLLLPSDTSQGP
EPATSQISIWVRATENPC*KPDHKSGALGPIGE
GRKSLKISVHPCTYSGTACLVFTLCLKVASPRPF
VCLGGLGPVRWQRRIKCAAAFAENNSETQNPPT
AQLLFFQCFPTRAK*HHVQKTPFFLEY*NRSAC
KIWDNDLFILKF*LNYLRI
Sequence INSR.aAug05
TCCCGCCGCCCGCCCGCCACCCGCCAGCCCAGGTGCCCGCCCGCCAGTCAGCTAGTCCGTCGGTCCGCGCGTCCCTCTGTCCCGGAGCCCGCAGATCGCGACCCAGAGCGCGCGGGGCCGAGAGCCGAGAGACAGTCCCGGGCGCAGCGCGGAGCTCCGGGCCCCGAGATCCTGGGACGGGGCCCGGGCCGCAGCGGCCG
GGGGGTCGGGGCCACCACCGCAAGGGCCTCCGCTCAGTATTTGTAGCTGGCGAAGCCGCGCGCGCCCTTCCCGGGGCTGCCTCTGGGCCCTCCCCGGCAG
GGGGGCTGCGGCCCGCGGGTCGCGGGCGTGGAAGAGAAGGACGCGCGGCCCCCAGCGCCTCTTGGGTGGCCGCCTCGGAGCATGACCCCCGCGGGCCAGC
GCCGCGCGCTCTGATCCGAGGAGACCCCGCGCTCCCGCAGCCATGGCCACCGGGGGCCGGCGGGGGGCGGCGGCCGCGCCGCTGCTGGTGGCGGTGGCCG
CGCTGCTACTGGGCGCCGCGGGCCACCTGTACCCCGGAGAGGTGTGTCCCGGCATGGATATCCGGAACAACCTCACTAGGTTGCATGAGCTGGAGAATTG
CTCTGTCATCGAAGGACACTTGCAGATACTCTTGATGTTCAAAACGAGGCCCGAAGATTTCCGAGACCTCAGTTTCCCCAAACTCATCATGATCACTGAT
TACTTGCTGCTCTTCCGGGTCTATGGGCTCGAGAGCCTGAAGGACCTGTTCCCCAACCTCACGGTCATCCGGGGATCACGACTGTTCTTTAACTACGCGC
TGGTCATCTTCGAGATGGTTCACCTCAAGGAACTCGGCCTCTACAACCTGATGAACATCACCCGGGGTTCTGTCCGCATCGAGAAGAACAATGAGCTCTG
TTACTTGGCCACTATCGACTGGTCCCGTATCCTGGATTCCGTGGAGGATAATTACATCGTGTTGAACAAAGATGACAACGAGGAGTGTGGAGACATCTGT
CCGGGTACCGCGAAGGGCAAGACCAACTGCCCCGCCACCGTCATCAACGGGCAGTTTGTCGAACGATGTTGGACTCATAGTCACTGCCAGAAAGTTTGCC
CGACCATCTGTAAGTCACACGGCTGCACCGCCGAAGGCCTCTGTTGCCACAGCGAGTGCCTGGGCAACTGTTCTCAGCCCGACGACCCCACCAAGTGCGT
GGCCTGCCGCAACTTCTACCTGGACGGCAGGTGTGTGGAGACCTGCCCGCCCCCGTACTACCACTTCCAGGACTGGCGCTGTGTGAACTTCAGCTTCTGC
CAGGACCTGCACCACAAATGCAAGAACTCGCGGAGGCAGGGCTGCCACCAGTACGTCATTCACAACAACAAGTGCATCCCTGAGTGTCCCTCCGGGTACA
CGATGAATTCCAGCAACTTGCTGTGCACCCCATGCCTGGGTCCCTGTCCCAAGGTGTGCCACCTCCTAGAAGGCGAGAAGACCATCGACTCGGTGACGTC
TGCCCAGGAGCTCCGAGGATGCACCGTCATCAACGGGAGTCTGATCATCAACATTCGAGGAGGCAACAATCTGGCAGCTGAGCTAGAAGCCAACCTCGGC
CTCATTGAAGAAATTTCAGGGTATCTAAAAATCCGCCGATCCTACGCTCTGGTGTCACTTTCCTTCTTCCGGAAGTTACGTCTGATTCGAGGAGAGACCT
TGGAAATTGGGAACTACTCCTTCTATGCCTTGGACAACCAGAACCTAAGGCAGCTCTGGGACTGGAGCAAACACAACCTCACCATCACTCAGGGGAAACT
CTTCTTCCACTATAACCCCAAACTCTGCTTGTCAGAAATCCACAAGATGGAAGAAGTTTCAGGAACCAAGGGGCGCCAGGAGAGAAACGACATTGCCCTG
AAGACCAATGGGGACCAGGCATCCTGTGAAAATGAGTTACTTAAATTTTCTTACATTCGGACATCTTTTGACAAGATCTTGCTGAGATGGGAGCCGTACT
GGCCCCCCGACTTCCGAGACCTCTTGGGGTTCATGCTGTTCTACAAAGAGGCCCCTTATCAGAATGTGACGGAGTTCGACGGGCAGGATGCGTGTGGTTC
CAACAGTTGGACGGTGGTAGACATTGACCCACCCCTGAGGTCCAACGACCCCAAATCACAGAACCACCCAGGGTGGCTGATGCGGGGTCTCAAGCCCTGG
ACCCAGTATGCCATCTTTGTGAAGACCCTGGTCACCTTTTCGGATGAACGCCGGACCTATGGGGCCAAGAGTGACATCATTTATGTCCAGACAGATGCCA
CCAACCCCTCTGTGCCCCTGGATCCAATCTCAGTGTCTAACTCATCATCCCAGATTATTCTGAAGTGGAAACCACCCTCCGACCCCAATGGCAACATCAC
CCACTACCTGGTTTTCTGGGAGAGGCAGGCGGAAGACAGTGAGCTGTTCGAGCTGGATTATTGCCTCAAAGGGCTGAAGCTGCCCTCGAGGACCTGGTCT
CCACCATTCGAGTCTGAAGATTCTCAGAAGCACAACCAGAGTGAGTATGAGGATTCGGCCGGCGAATGCTGCTCCTGTCCAAAGACAGACTCTCAGATCC
TGAAGGAGCTGGAGGAGTCCTCGTTTAGGAAGACGTTTGAGGATTACCTGCACAACGTGGTTTTCGTCCCCAGAAAAACCTCTTCAGGCACTGGTGCCGA
GGACCCTAGGCCATCTCGGAAACGCAGGTCCCTTGGCGATGTTGGGAATGTGACGGTGGCCGTGCCCACGGTGGCAGCTTTCCCCAACACTTCCTCGACC
AGCGTGCCCACGAGTCCGGAGGAGCACAGGCCTTTTGAGAAGGTGGTGAACAAGGAGTCGCTGGTCATCTCCGGCTTGCGACACTTCACGGGCTATCGCA
TCGAGCTGCAGGCTTGCAACCAGGACACCCCTGAGGAACGGTGCAGTGTGGCAGCCTACGTCAGTGCGAGGACCATGCCTGAAGCCAAGGCTGATGACAT
TGTTGGCCCTGTGACGCATGAAATCTTTGAGAACAACGTCGTCCACTTGATGTGGCAGGAGCCGAAGGAGCCCAATGGTCTGATCGTGCTGTATGAAGTG
AGTTATCGGCGATATGGTGATGAGGAGCTGCATCTCTGCGTCTCCCGCAAGCACTTCGCTCTGGAACGGGGCTGCAGGCTGCGTGGGCTGTCACCGGGGA
ACTACAGCGTGCGAATCCGGGCCACCTCCCTTGCGGGCAACGGCTCTTGGACGGAACCCACCTATTTCTACGTGACAGACTATTTAGACGTCCCGTCAAA
TATTGCAAAAATTATCATCGGCCCCCTCATCTTTGTCTTTCTCTTCAGTGTTGTGATTGGAAGTATTTATCTATTCCTGAGAAAGAGGCAGCCAGATGGG
CCGCTGGGACCGCTTTACGCTTCTTCAAACCCTGAGTATCTCAGTGCCAGTGATGTGTTTCCATGCTCTGTGTACGTGCCGGACGAGTGGGAGGTGTCTC
GAGAGAAGATCACCCTCCTTCGAGAGCTGGGGCAGGGCTCCTTCGGCATGGTGTATGAGGGCAATGCCAGGGACATCATCAAGGGTGAGGCAGAGACCCG
CGTGGCGGTGAAGACGGTCAACGAGTCAGCCAGTCTCCGAGAGCGGATTGAGTTCCTCAATGAGGCCTCGGTCATGAAGGGCTTCACCTGCCATCACGTG
GTGCGCCTCCTGGGAGTGGTGTCCAAGGGCCAGCCCACGCTGGTGGTGATGGAGCTGATGGCTCACGGAGACCTGAAGAGCTACCTCCGTTCTCTGCGGC
CAGAGGCTGAGAATAATCCTGGCCGCCCTCCCCCTACCCTTCAAGAGATGATTCAGATGGCGGCAGAGATTGCTGACGGGATGGCCTACCTGAACGCCAA
GAAGTTTGTGCATCGGGACCTGGCAGCGAGAAACTGCATGGTCGCCCATGATTTTACTGTCAAAATTGGAGACTTTGGAATGACCAGAGACATCTATGAA
ACGGATTACTACCGGAAAGGGGGCAAGGGTCTGCTCCCTGTACGGTGGATGGCACCGGAGTCCCTGAAGGATGGGGTCTTCACCACTTCTTCTGACATGT
GGTCCTTTGGCGTGGTCCTTTGGGAAATCACCAGCTTGGCAGAACAGCCTTACCAAGGCCTGTCTAATGAACAGGTGTTGAAATTTGTCATGGATGGAGG
GTATCTGGATCAACCCGACAACTGTCCAGAGAGAGTCACTGACCTCATGCGCATGTGCTGGCAATTCAACCCCAAGATGAGGCCAACCTTCCTGGAGATT
GTCAACCTGCTCAAGGACGACCTGCACCCCAGCTTTCCAGAGGTGTCGTTCTTCCACAGCGAGGAGAACAAGGCTCCCGAGAGTGAGGAGCTGGAGATGG
AGTTTGAGGACATGGAGAATGTGCCCCTGGACCGTTCCTCGCACTGTCAGAGGGAGGAGGCGGGGGGCCGGGATGGAGGGTCCTCGCTGGGTTTCAAGCG
GAGCTACGAGGAACACATCCCTTACACACACATGAACGGAGGCAAGAAAAACGGGCGGATTCTGACCTTGCCTCGGTCCAATCCTTCCTAACAGTGCCTA
CCGTGGCGGGGGCGGGCAGGGGTTCCCATTTTCGCTTTCCTCTGGTTTGAAAGCCTCTGGAAAACTCAGGATTCTCACGACTCTACCATGTCCAATGGAG
TTCAGAGATCGTTCCTATACATTTCTGTTCATCTTAAGGTGGACTCGTTTGGTTACCAATTTAACTAGTCCTGCAGAGGATTTAACTGTGAACCTGGAGG
GCAAGGGGTTTCCACAGTTGCTGCTCCTTTGGGGCAACGACGGTTTCAAACCAGGATTTTGTGTTTTTTCGTTCCCCCCACCCGCCCCCAGCAGATGGAA
AGAAAGCACCTGTTTTTACAAATTCTTTTTTTTTTTTTTTTTTTTTGCTGGTGTCTGAGCTTCAGTATAAAAGACAAAACTTCCTGTTTGTGGAACAAAA
GTTCGAAAGAAAAAACAAAACAAAAACACCCAGCCCTGTTCCAGGAGAATTTCAAGTTTTACAGGTTGAGCTTCAAGATGGTTTTTTTGGTTTTTTTTTT
TTCTCTCATCCAGGCTGAAGGATTTTTTTTTTCTTTACAAAATGAGTTCCTCAAATTGACCAATAGCTGCTGCTTTCATATTTTGGATAAGGGTCTGTGG
TCCCGGCGTGTGCTCACGTGTGTATGCACGTGTGTGTGTCCATTAGACACGGCTGATGTGTGTGCAAAGTATCCATGCGGAGTTGATGCTTTGGGAATTG
GCTCATGAAGGTTCTTCTCAAGGGTGCGAGCTCATCCCCCTCTCTCCTTCCTTCTTATTGACTGGGAGACTGTGCTCTCGACAGATTCTTCTTGTGTCAG
AAGTCTAGCCTCAGGTTTCTACCCTCCCTTCACATTGGTGGCCAAGGGAGGAGCATTTCATTTGGAGTGATTATGAATCTTTTCAAGACCAAACCAAGCT
AGGACATTAAAAAAAAAAAAAGAAAAAGAAAGAAAAAACAAAATGGAAAAAGGAAAAAAAAAAAGAACTGAGATGACAGAGTTTTGAGAATATATTTGTA
CCATATTTAATTTTTAAAGTCTCTGGTATTAGCCTCATAAGTTATTGACTATTCCCCGGGGTTGGCGGGGAGTGGGGACATGAGTTGGTCTGCCTGTTGT
GGGGCCGGGAAGGGGAGGGAGTCAGGCACAAGTGGCCTCTTTGTTTGGTCTTAAAGGCATCCATTTCTGGGAATGAAGCCATGTTCGCTGCTAACACTTT
TGGATGTTGTGAGGCCACGTGGAGTGTGTGAGAGACTAGGTTTTATGGATGGTCTGGTTCAGGTACCAGGTCTGCTGGAAGGTTCCTGTTCGGATAAGCT
GGTAGCTACCTAGCTCTGAGCCTGCCTTCAAGAACACCTGTGTTCATCCTCTGATTCTCTGTGTGTACCTCTTGTGGCGTTTCCTCTCCCGGGTGTGAAC
ATCCTAACCGTTATTGTGCAAACCCAAGAACGTCAGATCCCAAAGCACAACAACCTGGATGGACTTTGGGAACATCTAAGCAATGTAAGAGAGAGGTGCA
CTGAGAGTACGTCTTGGTCCCCTCCACCCTGAGAGCATCTGACGGTCCTCAGTACTGAACTCCCGGAAGCTGCTCTGAGCCCGGTGACCTCATCTGGGCC
AGGTGTGGTGCCTGAGCTGAATGCTCAGGTGCTTACAGTGTTGCAATCCCTAAGAGAGTAGAGTCTGGAGGAGAAACCGTGAAAAAGACCTTACACACCA
CCAAGAACTTCCGAATGGGCGTGAATCCACCGTTTCTTCTCTTTGCAAAAAGAACCACCACAGCTGCTCAAAGAACACAGTGAACTCATCACTTTGGTTC
ATCAAAAAATCATCGCCCATGCGTTATTCCTGAGTGCATTTTCTTACAACTTTTTGACTGCTTCCTTTTCTTCTTCTCTTAAGAGTTGTGGGCTTAAGAA
TGGGATAGAGTCATAATGGCAACCTCCAAGCCCTCTCAATTCTTGATTAAGAACACAGGTAGACATGAATCCCAATTGTCTATTGCTATCTTATTTATAT
GATTCGGGAAAATACAGCATGTAAAAATATTGCTGAGGAGCCTCAGTGATTGGGTACAAGAAGCAAGAGTACAGAAATTATTTTTGCCAAATTTATTTTG
TAAATATGAGGGTCTGTACCTAAATTTAAAAAAAAAACACGTAGAACTAGGTATTTTGTTCTCTTCTTAGTAAATTTGTAGTGGTTGTATACTACACTAG
CTGCAATTTTCACATTTTTCTAATTCAGAAAGGTTTTTCTTATATTAGGGGAAAAAGTATTTATTTTAATATATAAAATCACTCTGAAAATCACTCTCAT
AAAAAATGGAGCGCATGTAAATTTTTATCAAAGAAAAATAAACAGGTGAATGGGGGATAGTGATTTTCTTTTTTCAGCACAGTCTACCTCAGTGTATTGT
TAAGATGTGATTCAATCATGGACATCTTTGAGATTTCAGAATTCTACCTGGAACCGGTCTGAATCAGGGAACGTGTGTATCAGCTGATTCGAATGCCAGG
GACCAGTAAGAATTTTGAGGGAGGGAGTTGGGATGGAGAAGGTATGGCCTTTATGCGAGCATAGATCCTTTTCTTCCTGGCTGGTAATATTCTTCTCTGA
ATTTAATCTTCCTTTAAAAAAAAATCCTCCATCTATTGTCACTATGTTCCCCAAACATAAACTAAGTTCCAGGCTGTCATGATGTATCTGATATATGGGG
TAACCCAGCAAGGTGTACCTTCCTTTGGTGAGAGATGGCTGCCGGGGCAAAGACGGGCTTTGATTCAGAGCAAGCATTCCCACCTGTTCCATGGAATCCC
CCTGAAGTGAGCACAAAGGTGCCCTGGGCTCCCTGATGGTTTATGCCCACTCCTTTCAGGCTGGTGATGCACCTTACACACAAACACCTAATGCAATGTC
TTTTTAAATTCTCCAAGTGGGATGGGAGCATGTGAGGGAAATTCCAATCCAAAACCCATTAATGTGCTGAACGCTTTTTTTTTTTTTTTTTTTTTTTTTG
CAACAACACCTTGGACCTCTGTGTTGGGGTTTGACTGACCTCAAGCTGATATTATTGGACCTTGTGCAGCTTTGATAACCCATGTGAGAGTCTAGGCAGG
ACCAGTGGGGCCCAAATCTTGCTGCTCTTGTACTTTTAGGCACTGCCCTTGCAGACTCACCTTTCTCCACCTGCCCTGGAGAAAGGTAGGGTGTGCTGGG
CCTGCCCCTTGCAAATGGGATTCACCAGTTTCATTTATTTGACTCTACTGCCACAGTGAAAAGAGCAAACAGCTATTGGGTTGCAAACCTCCTTTGACAT
TAGGAAATGTTGACTTTGTAACAATAAAACTTTGGTCCTAGAAAGACACGGTTGTCCTGGGAGTTTGTAGTGTTAAGTTGCAACAACAACAACAAAAAGC
AACAAAACCAGCTTAGGATAACACTTTTTGTTGCTTGTTCTTAAAGATGTCTCACTATGATTAAAACCCTTTTCATTAATGTAGTGAAAGCCACACAGGA
GTTCCTTCTTCCAGGAGGAGAATACCAAGCACATCACTTTCTCTCTGCATCAGTGATGTCAAATACGCATCAGAAAATGTTCAGGTTTTAGGAGCTGTCC
TAGGTGCTGTTTCATCATTGGAAGCAGTGAGAAAGAGAAGCACTGCTGCTTGTCTGGATATAGGCTGAGGATGATTGAGAGAAGCTGTGGGAACTGACAC
AAGGGTCTGCATAGGTCATCCTGTGACCCTGGGGACTATGTTACCAACTGACAGACAGATCTTTCACTGTATCCTAGCAGGGCAGGTAGTCCACCAAGAA
ATGTGCTTATTGGATTGGGAGGTGTTTATTTGTAGTCTGCTGTAACACGTGTGAAAGAGCAGGAGCGTCATCAGCATATGACTTGCGCTGGTCATCCGGT
AAATGGATGTGCTGTAGTCCCAGTGCTAATCATTTCTCTCCTTCACAGTGGGTGGAAGTTTAGGGTTAAATGTCCTTTGAATGTCACCTGGTGAGTCCTT
GACACCTTAGGCTCTTCAGAAACAATGGTTTTGTTGAGGATGGGGAACAGGGAATGCCGATTTTATATACATGGTACACAGAGAGGGGTGTCACTTCAGA
AAATCTTCCAGCATGTTCTTCAGAATATTAATTTATATGCGAGGTGAGGTTGGGAATGAAAAGAACAGGTCAGCACTTTTTTTTTTCCTAGAACATACAA
AAGAACATGGTGGACTTTCAGGGAGTGCAATGGAAGGTGAATATTTCCTTAAGGGTCCCCGAGAAATGGGAGTGAGGGGAGGGGACACAATGGCTTTTTG
AGCTTACTTTTACCTTCTGATACTAGTCAAGGTCCAGAACCAGCCACCAGCCAAATTTCTATCTGGGTGCGGGCCACTGAAAATCCTTGTTAAAAACCAG
ATCACAAATCTGGGGCTCTTGGTCCCATTGGAGAAGGAAGGAAGAGCCTCAAAATAAGTGTGCACCCATGCACATATTCAGGAACAGCTTGTTTAGTCTT
TACACTTTGCCTGAAAGTTGCTTCTCCTCGTCCCTTTGTGTGCCTGGGTGGCCTCGGCCCTGTGCGTTGGCAACGCAGGATCAAATGTGCTGCAGCTTTT
GCAGAAAACAACTCAGAAACACAAAACCCCCCAACAGCTCAATTATTATTTTTTCAATGTTTTCCTACAAGAGCCAAGTAGCACCATGTACAGAAGACGC
CTTTTTTTTTGGAATATTGAAATCGTTCTGCATGTAAAATATGGGATAATGACCTGTTTATATTAAAATTCTGATTAAATTATCTGAGAATA
- INSR.u.f.13 (forward primer)
- INSR.u.r.17 (reverse primer)
- Single exon skipping
Frame 0
SRRPPATRQPRCPPASQLVRRSARPSVPEPADRDPERAGPRAERQSRAQRGAPGPEILGRGPGRSGR
GVGATTARASAQYL*LAKPRAPFPGLPLGPPRQ
GGCGPRVAGVEEKDARPPAPLGWPPRSMTPAGQ
RRAL*SEETPRSRSHGHRGPAGGGGRAAAGGGGR
AATGRRGPPVPRRGVSRHGYPEQPH*VA*AGEL
LCHRRTLADTLDVQNEARRFPRPQFPQTHHDH*
LLAALPGLWAREPEGPVPQPHGHPGITTVL*LRA
GHLRDGSPQGTRPLQPDEHHPGFCPHREEQ*AL
LLGHYRLVPYPGFRGG*LHRVEQR*QRGVWRHL
SGYREGQDQLPRHRHQRAVCRTMLDS*SLPESLP
DHL*VTRLHRRRPLLPQRVPGQLFSARRPHQVR
GLPQLLPGRQVCGDLPAPVLPLPGLALCELQLL
PGPAPQMQELAEAGLPPVRHSQQQVHP*VSLRVH
DEFQQLAVHPMPGSLSQGVPPPRRREDHRLGDV
CPGAPRMHRHQRESDHQHSRRQQSGS*ARSQPR
PH*RNFRVSKNPPILRSGVTFLLPEVTSDSRRDL
GNWELLLLCLGQPEPKAALGLEQTQPHHHSGET
LLPL*PQTLLVRNPQDGRSFRNQGAPGEKRHCP
EDQWGPGIL*K*VT*IFLHSDIF*QDLAEMGAVL
APRLPRPLGVHAVLQRGPLSECDGVRRAGCVWF
QQLDGGRH*PTPEVQRPQITEPPRVADAGSQAL
DPVCHLCEDPGHLFG*TPDLWGQE*HHLCPDRCH
QPLCAPGSNLSV*LIIPDYSEVETTLRPQWQHH
PLPGFLGEAGGRQ*AVRAGLLPQRAEAALEDLV
STIRV*RFSEAQPE*V*GFGRRMLLLSKDRLSDP
EGAGGVLV*EDV*GLPAQRGFRPQKNLFRHWCR
GP*AISETQVPWRCWECDGGRAHGGSFPQHFLD
QRAHESGGAQAF*EGGEQGVAGHLRLATLHGLSH
RAAGLQPGHP*GTVQCGSLRQCEDHA*SQG**H
CWPCDA*NL*EQRRPLDVAGAEGAQWSDRAV*S
ELSAIW**GAASLRLPQALRSGTGLQAAWAVTGE
LQRANPGHLPCGQRLLDGTHLFLRDRLFRRPVK
YCKNYHRPPHLCLSLQCCDWKYLSIPEKEAARW
AAGTALRFFKP*VSQCQ*CVSMLCVRAGRVGGVS
REDHPPSRAGAGLLRHGV*GQCQGHHQG*GRDP
RGGEDGQRVSQSPRAD*VPQ*GLGHEGLHLPSR
GAPPGSGVQGPAHAGGDGADGSRRPEELPPFSAA
RG*E*SWPPSPYPSRDDSDGGRDC*RDGLPERQ
EVCASGPGSEKLHGRP*FYCQNWRLWNDQRHL*
NGLLPERGQGSAPCTVDGTGVPEGWGLHHFF*HV
VLWRGPLGNHQLGRTALPRPV**TGVEICHGWR
VSGSTRQLSRESH*PHAHVLAIQPQDEANLPGD
CQPAQGRPAPQLSRGVVLPQRGEQGSRE*GAGDG
V*GHGECAPGPFLALSEGGGGGPGWRVLAGFQA
ELRGTHPLHTHERRQEKRADSDLASVQSFLTVP
TVAGAGRGSHFRFPLV*KPLENSGFSRLYHVQWS
SEIVPIHFCSS*GGLVWLPI*LVLQRI*L*TWR
ARGFHSCCSFGATTVSNQDFVFFRSPHPPPADG
KKAPVFTNSFFFFFFLLVSELQYKRQNFLFVEQK
FERKNKTKTPSPVPGEFQVLQVELQDGFFGFFF
FSHPG*RIFFFFTK*VPQIDQ*LLLSYFG*GSV
VPACAHVCMHVCVSIRHG*CVCKVSMRS*CFGNW
LMKVLLKGASSSPSLLPSY*LGDCALDRFFLCQ
KSSLRFLPSLHIGGQGRSISFGVIMNLFKTKPS
*DIKKKKRKRKKKQNGKRKKKKN*DDRVLRIYLY
HI*FLKSLVLAS*VIDYSPGLAGSGDMSWSACC
GAGKGRESGTSGLFVWS*RHPFLGMKPCSLLTL
LDVVRPRGVCERLGFMDGLVQVPGLLEGSCSDKL
VAT*L*ACLQEHLCSSSDSLCVPLVAFPLPGVN
ILTVIVQTQERQIPKHNNLDGLWEHLSNVRERC
TESTSWSPPP*EHLTVLSTELPEAALSPVTSSGP
GVVPELNAQVLTVLQSLRE*SLEEKP*KRPYTP
PRTSEWA*IHRFFSLQKEPPQLLKEHSELITLV
HQKIIAHALFLSAFSYNFLTASFSSSLKSCGLKN
GIES*WQPPSPLNS*LRTQVDMNPNCLLLSYLY
DSGKYSM*KYC*GASVIGYKKQEYRNYFCQIYF
VNMRVCT*I*KKNT*N*VFCSLLSKFVVVVYYTS
CNFHIFLIQKGFSYIRGKSIYFNI*NHSENHSH
KKWSACKFLSKKNKQVNGG**FSFFSTVYLSVL
LRCDSIMDIFEISEFYLEPV*IRERVYQLIRMPG
TSKNFEGGSWDGEGMAFMRA*ILFFLAGNILL*
I*SSFKKKSSIYCHYVPQT*TKFQAVMMYLIYG
VTQQGVPSFGERWLPGQRRALIQSKHSHLFHGIP
LK*AQRCPGLPDGLCPLLSGW*CTLHTNT*CNV
FLNSPSGMGACEGNSNPKPINVLNAFFFFFFFF
ATTPWTSVLGFD*PQADIIGPCAALITHVRV*AG
PVGPKSCCSCTFRHCPCRLTFLHLPWRKVGCAG
PAPCKWDSPVSFI*LYCHSEKSKQLLGCKPPLT
LGNVDFVTIKLWS*KDTVVLGVCSVKLQQQQQKA
TKPA*DNTFCCLFLKMSHYD*NPFH*CSESHTG
VPSSRRRIPSTSLSLCISDVKYASENVQVLGAV
LGAVSSLEAVRKRSTAACLDIG*G*LREAVGTDT
RVCIGHPVTLGTMLPTDRQIFHCILAGQVVHQE
MCLLDWEVFICSLL*HV*KSRSVISI*LALVIR
*MDVL*SQC*SFLSFTVGGSLGLNVL*MSPGESL
TP*ALQKQWFC*GWGTGNADFIYMVHREGCHFR
KSSSMFFRILIYMRGEVGNEKNRSALFFFLEHT
KEHGGLSGSAMEGEYFLKGPREMGVRGGDTMAF*
AYFYLLILVKVQNQPPAKFLSGCGPLKILVKNQ
ITNLGLLVPLEKEGRASK*VCTHAHIQEQLV*S
LHFA*KLLLLVPLCAWVASALCVGNAGSNVLQLL
QKTTQKHKTPQQLNYYFFNVFLQEPSSTMYRRR
LFFWNIEIVLHVKYGIMTCLY*NSD*II*E
Frame 1
PAARPPPASPGARPPVS*SVGPRVPLSRSPQIATQSARGREPRDSPGRSAELRAPRSWDGARAAAA
GGSGPPPQGPPLSICSWRSRARPSRGCLWALPGR
GAAARGSRAWKRRTRGPQRLLGGRLGA*PPRAS
AARSDPRRPRAPAAMATGGRRGAAAAPLLVAVA
ALLLGAAGHLYPGEVCPGMDIRNNLTRLHELENC
SVIEGHLQILLMFKTRPEDFRDLSFPKLIMITD
YLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYA
LVIFEMVHLKELGLYNLMNITRGSVRIEKNNELC
YLATIDWSRILDSVEDNYIVLNKDDNEECGDIC
PGTAKGKTNCPATVINGQFVERCWTHSHCQKVC
PTICKSHGCTAEGLCCHSECLGNCSQPDDPTKCV
ACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFC
QDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGY
TMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTS
AQELRGCTVINGSLIINIRGGNNLAAELEANLG
LIEEISGYLKIRRSYALVSLSFFRKLRLIRGET
LEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKL
FFHYNPKLCLSEIHKMEEVSGTKGRQERNDIAL
KTNGDQASCENELLKFSYIRTSFDKILLRWEPY
WPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGS
NSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPW
TQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDA
TNPSVPLDPISVSNSSSQIILKWKPPSDPNGNIT
HYLVFWERQAEDSELFELDYCLKGLKLPSRTWS
PPFESEDSQKHNQSEYEDSAGECCSCPKTDSQI
LKELEESSFRKTFEDYLHNVVFVPRKTSSGTGAE
DPRPSRKRRSLGDVGNVTVAVPTVAAFPNTSST
SVPTSPEEHRPFEKVVNKESLVISGLRHFTGYR
IELQACNQDTPEERCSVAAYVSARTMPEAKADDI
VGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEV
SYRRYGDEELHLCVSRKHFALERGCRLRGLSPG
NYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSN
IAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDG
PLGPLYASSNPEYLSASDVFPCSVYVPDEWEVS
REKITLLRELGQGSFGMVYEGNARDIIKGEAETR
VAVKTVNESASLRERIEFLNEASVMKGFTCHHV
VRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLR
PEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAK
KFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYE
TDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDM
WSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGG
YLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEI
VNLLKDDLHPSFPEVSFFHSEENKAPESEELEM
EFEDMENVPLDRSSHCQREEAGGRDGGSSLGFKR
SYEEHIPYTHMNGGKKNGRILTLPRSNPS*QCL
PWRGRAGVPIFAFLWFESLWKTQDSHDSTMSNG
VQRSFLYISVHLKVDSFGYQFN*SCRGFNCEPGG
QGVSTVAAPLGQRRFQTRILCFFVPPTRPQQME
RKHLFLQILFFFFFFCWCLSFSIKDKTSCLWNK
SSKEKTKQKHPALFQENFKFYRLSFKMVFLVFFF
SLIQAEGFFFSLQNEFLKLTNSCCFHILDKGLW
SRRVLTCVCTCVCPLDTADVCAKYPCGVDALGI
GS*RFFSRVRAHPPLSFLLIDWETVLSTDSSCVR
SLASGFYPPFTLVAKGGAFHLE*L*IFSRPNQA
RTLKKKKEKERKNKMEKGKKKRTEMTEF*EYIC
TIFNF*SLWY*PHKLLTIPRGWRGVGT*VGLPVV
GPGRGGSQAQVASLFGLKGIHFWE*SHVRC*HF
WML*GHVECVRD*VLWMVWFRYQVCWKVPVRIS
W*LPSSEPAFKNTCVHPLILCVYLLWRFLSRV*T
S*PLLCKPKNVRSQSTTTWMDFGNI*AM*ERGA
LRVRLGPLHPESI*RSSVLNSRKLL*AR*PHLG
QVWCLS*MLRCLQCCNP*ESRVWRRNREKDLTHH
QELPNGRESTVSSLCKKNHHSCSKNTVNSSLWF
IKKSSPMRYS*VHFLTTF*LLPFLLLLRVVGLR
MG*SHNGNLQALSILD*EHR*T*IPIVYCYLIYM
IRENTACKNIAEEPQ*LGTRSKSTEIIFAKFIL
*I*GSVPKFKKKTRRTRYFVLFLVNL*WLYTTL
AAIFTFF*FRKVFLILGEKVFILIYKITLKITLI
KNGAHVNFYQRKINR*MGDSDFLFSAQSTSVYC
*DVIQSWTSLRFQNSTWNRSESGNVCIS*FECQ
GPVRILREGVGMEKVWPLCEHRSFSSWLVIFFSE
FNLPLKKNPPSIVTMFPKHKLSSRLS*CI*YMG
*PSKVYLPLVRDGCRGKDGL*FRASIPTCSMES
P*SEHKGALGSLMVYAHSFQAGDAPYTQTPNAMS
F*ILQVGWEHVREIPIQNPLMC*TLFFFFFFFL
QQHLGPLCWGLTDLKLILLDLVQL**PM*ESRQ
DQWGPNLAALVLLGTALADSPFSTCPGER*GVLG
LPLANGIHQFHLFDSTATVKRANSYWVANLL*H
*EMLTL*Q*NFGPRKTRLSWEFVVLSCNNNNKK
QQNQLRITLFVACS*RCLTMIKTLFINVVKATQE
FLLPGGEYQAHHFLSASVMSNTHQKMFRF*ELS
*VLFHHWKQ*EREALLLVWI*AEDD*EKLWELT
QGSA*VIL*PWGLCYQLTDRSFTVS*QGR*STKK
CAYWIGRCLFVVCCNTCERAGASSAYDLRWSSG
KWMCCSPSANHFSPSQWVEV*G*MSFECHLVSP
*HLRLFRNNGFVEDGEQGMPILYTWYTERGVTSE
NLPACSSEY*FICEVRLGMKRTGQHFFFS*NIQ
KNMVDFQGVQWKVNISLRVPEKWE*GEGTQWLF
ELTFTF*Y*SRSRTSHQPNFYLGAGH*KSLLKTR
SQIWGSWSHWRRKEEPQNKCAPMHIFRNSLFSL
YTLPESCFSSSLCVPGWPRPCALATQDQMCCSF
CRKQLRNTKPPNSSIIIFSMFSYKSQVAPCTEDA
FFFGILKSFCM*NMG**PVYIKILIKLSEN
Frame 2
PPPARHPPAQVPARQSASPSVRASLCPGARRSRPRARGAESRETVPGAARSSGPRDPGTGPGPQRP
GGRGHHRKGLRSVFVAGEAARALPGAASGPSPA
GGLRPAGRGRGREGRAAPSASWVAASEHDPRGPA
PRALIRGDPALPQPWPPGAGGGRRPRRCWWRWP
RCYWAPRATCTPERCVPAWISGTTSLGCMSWRI
ALSSKDTCRYS*CSKRGPKISETSVSPNSS*SLI
TCCSSGSMGSRA*RTCSPTSRSSGDHDCSLTTR
WSSSRWFTSRNSASTT**TSPGVLSASRRTMSS
VTWPLSTGPVSWIPWRIITSC*TKMTTRSVETSV
RVPRRARPTAPPPSSTGSLSNDVGLIVTARKFA
RPSVSHTAAPPKASVATASAWATVLSPTTPPSA
WPAATSTWTAGVWRPARPRTTTSRTGAV*TSASA
RTCTTNARTRGGRAATSTSFTTTSASLSVPPGT
R*IPATCCAPHAWVPVPRCATS*KARRPSTR*R
LPRSSEDAPSSTGV*SSTFEEATIWQLS*KPTSA
SLKKFQGI*KSADPTLWCHFPSSGSYV*FEERP
WKLGTTPSMPWTTRT*GSSGTGANTTSPSLRGN
SSSTITPNSACQKSTRWKKFQEPRGARRETTLP*
RPMGTRHPVKMSYLNFLTFGHLLTRSC*DGSRT
GPPTSETSWGSCCSTKRPLIRM*RSSTGRMRVV
PTVGRW*TLTHP*GPTTPNHRTTQGG*CGVSSPG
PSMPSL*RPWSPFRMNAGPMGPRVTSFMSRQMP
PTPLCPWIQSQCLTHHPRLF*SGNHPPTPMATS
PTTWFSGRGRRKTVSCSSWIIASKG*SCPRGPGL
HHSSLKILRSTTRVSMRIRPANAAPVQRQTLRS
*RSWRSPRLGRRLRITCTTWFSSPEKPLQALVP
RTLGHLGNAGPLAMLGM*RWPCPRWQLSPTLPRP
ACPRVRRSTGLLRRW*TRSRWSSPACDTSRAIA
SSCRLATRTPLRNGAVWQPTSVRGPCLKPRLMT
LLAL*RMKSLRTTSST*CGRSRRSPMV*SCCMK*
VIGDMVMRSCISASPASTSLWNGAAGCVGCHRG
TTACESGPPPLRATALGRNPPIST*QTI*TSRQ
ILQKLSSAPSSLSFSSVL*LEVFIYS*ERGSQMG
RWDRFTLLQTLSISVPVMCFHALCTCRTSGRCL
ERRSPSFESWGRAPSAWCMRAMPGTSSRVRQRP
AWR*RRSTSQPVSESGLSSSMRPRS*RASPAITW
CASWEWCPRASPRWW*WS*WLTET*RATSVLCG
QRLRIILAALPLPFKR*FRWRQRLLTGWPT*TP
RSLCIGTWQRETAWSPMILLSKLETLE*PETSMK
RITTGKGARVCSLYGGWHRSP*RMGSSPLLLTC
GPLAWSFGKSPAWQNSLTKACLMNRC*NLSWME
GIWINPTTVQRESLTSCACAGNSTPR*GQPSWRL
STCSRTTCTPAFQRCRSSTARRTRLPRVRSWRW
SLRTWRMCPWTVPRTVRGRRRGAGMEGPRWVSS
GATRNTSLTHT*TEARKTGGF*PCLGPILPNSAY
RGGGGQGFPFSLSSGLKASGKLRILTTLPCPME
FRDRSYTFLFILRWTRLVTNLTSPAEDLTVNLE
GKGFPQLLLLWGNDGFKPGFCVFSFPPPAPSRWK
ESTCFYKFFFFFFFFAGV*ASV*KTKLPVCGTK
VRKKKQNKNTQPCSRRISSFTG*ASRWFFWFFF
FLSSRLKDFFFLYKMSSSN*PIAAAFIFWIRVCG
PGVCSRVYARVCVH*TRLMCVQSIHAELMLWEL
AHEGSSQGCELIPLSPSFLLTGRLCSRQILLVS
EV*PQVSTLPSHWWPREEHFIWSDYESFQDQTKL
GH*KKKKKKKEKTKWKKEKKKELR*QSFENIFV
PYLIFKVSGISLISY*LFPGVGGEWGHELVCLL
WGREGEGVRHKWPLCLVLKASISGNEAMFAANTF
GCCEATWSV*ETRFYGWSGSGTRSAGRFLFG*A
GSYLALSLPSRTPVFIL*FSVCTSCGVSSPGCE
HPNRYCANPRTSDPKAQQPGWTLGTSKQCKREVH
*EYVLVPSTLRASDGPQY*TPGSCSEPGDLIWA
RCGA*AECSGAYSVAIPKRVESGGETVKKTLHT
TKNFRMGVNPPFLLFAKRTTTAAQRTQ*THHFGS
SKNHRPCVIPECIFLQLFDCFLFFFS*ELWA*E
WDRVIMATSKPSQFLIKNTGRHESQLSIAILFI
*FGKIQHVKILLRSLSDWVQEARVQKLFLPNLFC
KYEGLYLNLKKKHVELGILFSS**ICSGCILH*
LQFSHFSNSERFFLY*GKKYLF*YIKSL*KSLS
*KMERM*IFIKEK*TGEWGIVIFFFQHSLPQCIV
KM*FNHGHL*DFRILPGTGLNQGTCVSADSNAR
DQ*EF*GRELGWRRYGLYASIDPFLPGW*YSSL
NLIFL*KKILHLLSLCSPNIN*VPGCHDVSDIWG
NPARCTFLW*EMAAGAKTGFDSEQAFPPVPWNP
PEVSTKVPWAP*WFMPTPFRLVMHLTHKHLMQC
LFKFSKWDGSM*GKFQSKTH*CAERFFFFFFFFC
NNTLDLCVGV*LTSS*YYWTLCSFDNPCESLGR
TSGAQILLLLYF*ALPLQTHLSPPALEKGRVCW
ACPLQMGFTSFIYLTLLPQ*KEQTAIGLQTSFDI
RKC*LCNNKTLVLERHGCPGSL*C*VATTTTKS
NKTSLG*HFLLLVLKDVSL*LKPFSLM**KPHR
SSFFQEENTKHITFSLHQ*CQIRIRKCSGFRSCP
RCCFIIGSSEKEKHCCLSGYRLRMIERSCGN*H
KGLHRSSCDPGDYVTN*QTDLSLYPSRAGSPPR
NVLIGLGGVYL*SAVTRVKEQERHQHMTCAGHPV
NGCAVVPVLIISLLHSGWKFRVKCPLNVTW*VL
DTLGSSETMVLLRMGNRECRFYIHGTQRGVSLQ
KIFQHVLQNINLYAR*GWE*KEQVSTFFFPRTYK
RTWWTFRECNGR*IFP*GSPRNGSEGRGHNGFL
SLLLPSDTSQGPEPATSQISIWVRATENPC*KP
DHKSGALGPIGEGRKSLKISVHPCTYSGTACLVF
TLCLKVASPRPFVCLGGLGPVRWQRRIKCAAAF
AENNSETQNPPTAQLLFFQCFPTRAK*HHVQKT
PFFLEY*NRSACKIWDNDLFILKF*LNYLRI
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