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Sequences

Sequence NEO1.aAug05

GGGCCGGGCCGGGCTGGGCTGGAGCAGCGGCGGCCGCGGGAGCCGAGCTTGCAGCGAGGGACCGGCTGAGGCGCGCGGGAGGGAAGGAGGCAAGGGCTCC GCGGCGCTGTCGCCGCCGCTGCCGCTCACTCTCGGGGAAGAGATGGCGGCGGAGCGGGGAGCCCGGCGACTCCTCAGCACCCCCTCCTTCTGGCTCTACT GCCTGCTGCTGCTCGGGCGCCGGGCGCCGGGCGCCGCGGCCGCCAGGAGCGGCTCCGCGCCGCAGTCCCCAGGAGCCAGCATTCGAACGTTCACTCCATT TTATTTTCTGGTGGAGCCGGTGGATACACTCTCAGTTAGAGGCTCTTCTGTTATATTAAACTGTTCAGCATATTCTGAGCCTTCTCCAAAAATTGAATGG AAAAAAGATGGAACTTTTTTAAACTTAGTATCAGATGATCGACGCCAGCTTCTCCCGGATGGATCTTTATTTATCAGCAATGTGGTGCATTCCAAACACA ATAAACCTGATGAAGGTTATTATCAGTGTGTGGCCACTGTTGAGAGTCTTGGAACTATTATCAGTAGAACAGCGAAGCTCATAGTAGCAGGTCTTCCAAG ATTTACCAGCCAACCAGAACCTTCCTCAGTTTATGCTGGGAACAATGCAATTCTGAATTGTGAAGTTAATGCAGATTTGGTCCCATTTGTGAGGTGGGAA CAGAACAGACAACCCCTTCTTCTGGATGATAGAGTTATCAAACTTCCAAGTGGAATGCTGGTTATCAGCAATGCAACTGAAGGAGATGGCGGGCTTTATC GCTGCGTAGTGGAAAGTGGTGGGCCACCAAAGTATAGTGATGAAGTTGAATTGAAGGTTCTTCCAGATCCTGAGGTGATATCAGACTTGGTATTTTTGAA ACAGCCTTCTCCCTTAGTCAGAGTCATTGGTCAGGATGTAGTGTTGCCATGTGTTGCTTCAGGACTTCCTACTCCAACCATTAAATGGATGAAAAATGAG GAGGCACTTGACACAGAAAGCTCTGAAAGATTGGTATTGCTGGCAGGTGGTAGCCTGGAGATCAGTGATGTTACTGAGGATGATGCTGGGACTTATTTTT GTATAGCTGATAATGGAAATGAGACAATTGAAGCTCAAGCAGAGCTTACAGTGCAAGCTCAACCTGAATTCCTGAAGCAGCCTACTAATATATATGCTCA CGAATCTATGGATATTGTATTTGAATGTGAAGTGACTGGAAAACCAACTCCAACTGTGAAGTGGGTCAAAAATGGGGATATGGTTATCCCAAGTGATTAT TTTAAGATTGTAAAGGAACATAATCTTCAAGTTTTGGGTCTGGTGAAATCAGATGAAGGGTTCTATCAGTGCATTGCTGAAAATGATGTTGGAAATGCAC AAGCTGGAGCCCAACTGATAATCCTTGAACATGCACCAGCCACAACGGGACCACTGCCTTCAGCTCCTCGGGATGTCGTGGCCTCCCTGGTCTCTACCCG CTTCATCAAATTGACGTGGCGGACACCTGCATCAGATCCTCACGGAGACAACCTTACCTACTCTGTGTTCTACACCAAGGAAGGGATTGCTAGGGAACGT GTTGAGAATACCAGTCACCCAGGAGAGATGCAAGTAACCATTCAAAACCTAATGCCAGCGACCGTGTACATCTTTAGAGTTATGGCTCAAAATAAGCATG GCTCAGGAGAGAGTTCAGCTCCACTGCGAGTAGAAACACAACCTGAGGTTCAGCTCCCTGGCCCAGCACCTAACCTTCGTGCATATGCAGCTTCGCCTAC CTCCATCACTGTTACGTGGGAAACACCAGTGTCTGGCAATGGGGAAATTCAGAATTATAAATTGTACTACATGGAAAAGGGGACTGATAAAGAACAGGAT GTTGATGTTTCAAGTCACTCTTACACCATTAATGGGTTGAAAAAATATACAGAGTATAGTTTCCGAGTGGTGGCCTACAATAAACATGGTCCTGGAGTTT CCACACCAGATGTTGCTGTTCGAACATTGTCAGATGTTCCCAGTGCTGCTCCTCAGAATCTGTCCTTGGAAGTGAGAAATTCAAAGAGTATTATGATTCA CTGGCAGCCACCTGCTCCAGCCACACAAAATGGGCAGATTACTGGCTACAAGATTCGCTACCGAAAGGCCTCCCGAAAGAGTGATGTCACTGAGACCTTG GTAAGCGGGACACAGCTGTCTCAGCTGATTGAAGGTCTTGATCGGGGGACTGAGTATAATTTCCGAGTGGCTGCTCTAACAATCAATGGTACAGGCCCGG CAACTGACTGGCTGTCTGCTGAAACTTTTGAAAGTGACCTAGATGAAACTCGTGTTCCTGAAGTGCCTAGCTCTCTTCACGTACGCCCGCTCGTTACTAG CATCGTAGTGAGCTGGACTCCTCCAGAGAATCAGAACATTGTGGTCAGAGGTTACGCCATTGGTTATGGCATTGGCAGCCCTCATGCCCAGACCATCAAA GTGGACTATAAACAGCGCTATTACACCATTGAAAATCTGGATCCCAGCTCTCACTATGTGATTACCCTGAAAGCATTTAATAACGTGGGTGAAGGCATCC CCCTGTATGAGAGTGCTGTGACCAGGCCTCACACAGACACTTCTGAAGTTGATTTATTTGTTATTAATGCTCCATACACTCCAGTGCCAGATCCCACTCC CATGATGCCACCAGTGGGAGTTCAGGCTTCCATTCTGAGTCATGACACCATCAGGATTACGTGGGCAGACAACTCGCTGCCCAAGCACCAGAAGATTACA GACTCCCGATACTACACCGTCCGATGGAAAACCAACATCCCAGCAAACACCAAGTACAAGAATGCAAATGCAACCACTTTGAGTTATTTGGTGACTGGTT TAAAGCCGAATACACTCTATGAATTCTCTGTGATGGTGACCAAAGGTCGAAGATCAAGTACATGGAGTATGACAGCCCATGGGACCACCTTTGAATTAGT TCCGACTTCTCCACCCAAGGATGTGACTGTTGTGAGTAAAGAGGGGAAACCTAAGACCATAATTGTGAATTGGCAGCCTCCCTCCGAAGCCAATGGCAAA ATTACAGGTTACATCATATATTACAGTACAGATGTGAATGCAGAGATACATGACTGGGTTATTGAGCCTGTTGTGGGAAACAGACTGACTCACCAGATAC AAGAGTTAACTCTTGACACACCATACTACTTCAAAATCCAGGCACGGAACTCAAAGGGCATGGGACCCATGTCTGAAGCTGTCCAATTCAGAACACCTAA AGCGGACTCCTCTGATAAAATGCCTAATGATCAAGCCTCAGGGTCTGGAGGGAAAGGAAGCCGGCTGCCAGACCTAGGATCCGACTACAAACCTCCAATG AGCGGCAGTAACAGCCCTCATGGGAGCCCCACCTCTCCTCTGGACAGTAATATGCTGCTGGTCATAATTGTTTCTGTTGGCGTCATCACCATCGTGGTGG TTGTGATTATCGCTGTCTTTTGTACCCGTCGTACCACCTCTCACCAGAAAAAGAAACGAGCTGCCTGCAAATCAGTGAATGGCTCTCATAAGTACAAAGG GAATTCCAAAGATGTGAAACCTCCAGATCTCTGGATCCATCATGAGAGACTGGAGCTGAAACCCATTGATAAGTCTCCAGACCCAAACCCCATCATGACT GATACTCCAATTCCTCGCAACTCTCAAGATATCACACCAGTTGACAACTCCATGGACAGCAATATCCATCAAAGGCGAAATTCATACAGAGGGCATGAGT CAGAGGACAGCATGTCTACACTGGCTGGAAGGCGAGGAATGAGACCAAAAATGATGATGCCCTTTGACTCCCAGCCACCCCAGCCTGTGATTAGTGCCCA TCCCATCCATTCCCTCGATAACCCTCACCATCATTTCCACTCCAGCAGCCTCGCTTCTCCAGCTCGCAGTCATCTCTACCACCCGGGCAGCCCATGGCCC ATTGGCACATCCATGTCCCTTTCAGACAGGGCCAATTCCACAGAATCCGTTCGAAATACCCCCAGCACTGACACCATGCCAGCCTCTTCGTCTCAAACAT GCTGCACTGATCACCAGGACCCTGAAGGTGCTACCAGCTCCTCTTACTTGGCCAGCTCCCAAGAGGAAGATTCAGGCCAGAGTCTTCCCACTGCCCATGT TCGCCCTTCCCACCCATTGAAGAGCTTCGCCGTGCCAGCAATCCCGCCTCCAGGACCTCCCACCTATGATCCTGCATTGCCAAGCACACCATTACTGTCC CAGCAAGCTCTGAACCATCACATTCACTCAGTGAAGACAGCCTCCATCGGGACTCTAGGAAGGAGCCGGCCTCCTATGCCAGTGGTTGTTCCCAGTGCCC CTGAAGTGCAGGAGACCACAAGGATGTTGGAAGACTCCGAGAGTAGCTATGAACCAGATGAGCTGACCAAAGAGATGGCCCACCTGGAAGGACTAATGAA GGACCTAAACGCTATCACAACAGCATGACGACCTTCACCAGGACCTGACTTCAAACCTGAGTCTGGAAGTCTTGGAACTTACCCTTGAAAACAAGGAATT GTACAGAGTACGAGAGGACAGCACTTGAGAACACAGAATGAGCCAGCAGACTGGCCAGCGCCTCTGTGTAGGGCTGGCTCCAGGCATGGCCACCTGCCTT CCCCTGGTCAGCCTGGAAGAAGCCTGTGTCGAGGCAGCTTCCCTTTGCCTGCTGATATTCTGCAGGACTGGGCACCATGGGCCAAAATTTTGTGTCCAGG GAAGAGGCGAGAAGTGCAACCTGCATTTCACTTTGTGGTCAGGCCGTGTCTTTGTGCTGTGACTGCATCACCTTTATGGAGTGTAGACATTGGCATTTAT GTACAATTTTATTTGTGTCTTATTTTATTTTACCTTCAAAAACAAAAACGCCATCCAAAACCAAGGAAGTCCTTGGTGTTCTCCACAAGTGGTTGACATT TGACTGCTTGTTCCAATTATGTATGGAAAGTCTTTGACAGTGTGGGTCGTTCCTGGGGTTGGCTTGTTTTTTGGTTTCATTTTTATTTTTTAATTCTGAG TCATTGCATCCTCTACCAGCTGTTAATCCATCACTCTGAGGGGGAGGAAATGTTGCATTGCTGTTTGTAAGCTTTTTTTATTATTTTTTTATTATAATTA TTAAAGGCCTGACTCTTTCCTCTCATCACTGTGAGATTACAGATCTATTTGAATTGAATGAAATGTAACATTGAAAAGACTTGTTTGTTGCTTTCTGTGC AGTTTCAGTATTGGGGCGGGTGGGGGGCTGGGGGTTGGTAATAGGAAATGGAGGGGCTGCTGAGGTCCTGTGAATGTTTCTGTCATTGTACTTTCTTCCA GAAGCCTGCAGAGAATGGAAGCATCTTCTTTATTGTCCTTTCCTGGCATGTCCATCCTTATTGTCACTACGTTGCAACTGGAGTTTGATTTGGATCTGGT TTTAAAATTCTTCTGTGCAATAGATGGGTTTGAGGATTTAGCGGCCCTGATGTCTTGGTCATAGCCTGGTAAGAATGTCCATGCTGAGGAGCCAGATGTT GTATTTCTAACTGCCTGAGTCACACAGAATAGGGTAAGAGCCTGACCCCATTCTGTAAATCAGAAAGCAAGGATGGAGACCCTTTCCTGCTGCTATTATT GGCTCTCTTTGAGGAAGTTGGAGGTTAAGGAAGGAACTTGTTTGTTTCCGTATACGACTCCTTCTTCTCTCTAGTTCAGTCTTCAGCCAGTCCAGCGCTC TCTTCCACACTTCAGAGCCCCTTCAGAGAAAGCATTAGCAGGAATGAGACAAGGCAGAGCTGCAGTGCCCCCTGAGGCTTCCACACATCTTTCTGAATAT TATTTTTCAAGTAACAAGGGCAGGGACAGCGGAAACAGCTGCCCACCCCCCCCATCCCAGCAGCTCAGCTAAGCCCTGATGAGAATGAAGCCACAGGAGT TGTCTGAGGTGAACCCAGCCGCTCAGCCACACATGGAAGCCATTGCCTTTGCACATAGTTCTTGGGTTCTTTTTCCTAAAAAGGTAAGGAGCTGAGGTGT GTGGTTTTTTAATATTAAGAATATATAATGGAAAACACACGACTGACGCTCAGGCATCTTCCCCTACTCCCCAACAGATCCCCAGAAGACAGCGTGGAAG GCAGTGTAGACAGTAAATCGGGCTTCAGTTCTATAGCCAAGAAGAGATCAGCTGCTGAAACCACCAGTGGGTACCCCAGGCCACCTGCCTTTGAACTTGG GGATTTGCCATGTTTGATCTTGTCACATACTTGCTTTTTTACAAGATGAACTCTTTGTATTTATGATTTGGGGGGCAATGAAAGGTGCAATGCAGGAACT GCTGCTGCCGAGCTCGCTGGTCACATGGGGGTGCCAGGCGGGATTCTGGAAAACCAGTGCACTTAAACTGATCCTGAAGAGAGCTGTCCCAGCACTCTGG CCACCAGGAGGGCCAGATTCCCCAGAAACTACCTTTTGCCCAAAGAACATGCTCAGTATTTGGGGCATTTCCTCCCACAAACCCTGACTGCTTCTGTTAC CTCAGGGCCTTGGTACCTGGATACTGCCACAGAATTGGGGCGGGTGGGGGAGGGGCCTATTTTTAAATAAAATAACTGTTCAAAGTTGGGGGTTTTTTAA AAAATTAAGAAAAAGGAAAGCTATTCTGTATTGCACCTTTTCACAATTTAATACATTTTCTTACATTTTCCTGTGATTTTCGAAACTAAACCATTGTGTG TCCTGTAGTGTCCTGGTTGAGCTGCCGCTCAGCAGCTTCCTCGGGGGGATTTGGAACACCTGTGTCTGTCGCCGCACTGCCTGTGGGAGGGGCCCAGAGG GCTGCTGGGACTGGCGTCTGTACACACTTGTTTGGCCTTTTCTGTAGTTGATGCTGTAAACTCTATGGCTTTTTAAAAACGATTTCATGTTTTTATTTAG TATTGGAAATCCAATACACTTTTTTAATCCAATCAAA

NEO1.u.f.8 (forward primer)
NEO1.u.r.13 (reverse primer)
Alternative acceptor

Frame 0

GPGRAGLEQRRPREPSLQRGTG*GAREGRRQGL RGAVAAAAAHSRGRDGGGAGSPATPQHPLLLALL PAAARAPGAGRRGRQERLRAAVPRSQHSNVHSI LFSGGAGGYTLS*RLFCYIKLFSIF*AFSKN*M EKRWNFFKLSIR*STPASPGWIFIYQQCGAFQTQ *T**RLLSVCGHC*ESWNYYQ*NSEAHSSRSSK IYQPTRTFLSLCWEQCNSEL*S*CRFGPICEVG TEQTTPSSG**SYQTSKWNAGYQQCN*RRWRALS LRSGKWWATKV***S*IEGSSRS*GDIRLGIFE TAFSLSQSHWSGCSVAMCCFRTSYSNH*MDEK* GGT*HRKL*KIGIAGRW*PGDQ*CY*G*CWDLFL YS**WK*DN*SSSRAYSASST*IPEAAY*YICS RIYGYCI*M*SDWKTNSNCEVGQKWGYGYPK*L F*DCKGT*SSSFGSGEIR*RVLSVHC*K*CWKCT SWSPTDNP*TCTSHNGTTAFSSSGCRGLPGLYP LHQIDVADTCIRSSRRQPYLLCVLHQGRDC*GT C*EYQSPRRDASNHSKPNASDRVHL*SYGSK*AW LRREFSSTASRNTT*GSAPWPST*PSCICSFAY LHHCYVGNTSVWQWGNSEL*IVLHGKGD**RTG C*CFKSLLHH*WVEKIYRV*FPSGGLQ*TWSWSF HTRCCCSNIVRCSQCCSSESVLGSEKFKEYYDS LAATCSSHTKWADYWLQDSLPKGLPKE*CH*DL GKRDTAVSAD*RS*SGD*V*FPSGCSNNQWYRPG N*LAVC*NF*K*PR*NSCS*SA*LSSRTPARY* HRSELDSSRESEHCGQRLRHWLWHWQPSCPDHQ SGL*TALLHH*KSGSQLSLCDYPESI**RG*RHP PV*ECCDQASHRHF*S*FICY*CSIHSSARSHS HDATSGSSGFHSES*HHQDYVGRQLAAQAPEDY RLPILHRPMENQHPSKHQVQECKCNHFELFGDWF KAEYTL*ILCDGDQRSKIKYMEYDSPWDHL*IS SDFSTQGCDCCE*RGET*DHNCELAASLRSQWQ NYRLHHILQYRCECRDT*LGY*ACCGKQTDSPDT RVNS*HTILLQNPGTELKGHGTHV*SCPIQNT* SGLL**NA**SSLRVWRERKPAARPRIRLQTSN ERQ*QPSWEPHLSSGQ*YAAGHNCFCWRHHHRGG CDYRCLLYPSYHLSPEKETSCLQISEWLS*VQR EFQRCETSRSLDPS*ETGAETH**VSRPKPHHD *YSNSSQLSRYHTS*QLHGQQYPSKAKFIQRA*V RGQHVYTGWKARNETKNDDAL*LPATPACD*CP SHPFPR*PSPSFPLQQPRFSSSQSSLPPGQPMA HWHIHVPFRQGQFHRIRSKYPQH*HHASLFVSNM LH*SPGP*RCYQLLLLGQLPRGRFRPESSHCPC SPFPPIEELRRASNPASRTSHL*SCIAKHTITV PASSEPSHSLSEDSLHRDSRKEPASYASGCSQCP *SAGDHKDVGRLRE*L*TR*ADQRDGPPGRTNE GPKRYHNSMTTFTRT*LQT*VWKSWNLPLKTRN CTEYERTALENTE*ASRLASASV*GWLQAWPPAF PWSAWKKPVSRQLPFAC*YSAGLGTMGQNFVSR EEARSATCISLCGQAVSLCCDCITFMECRHWHL CTILFVSYFILPSKTKTPSKTKEVLGVLHKWLTF DCLFQLCMESL*QCGSFLGLACFLVSFLFFNSE SLHPLPAVNPSL*GGGNVALLFVSFFYYFFIII IKGLTLSSHHCEITDLFELNEM*H*KDLFVAFCA VSVLGRVGGWGLVIGNGGAAEVL*MFLSLYFLP EACREWKHLLYCPFLACPSLLSLRCNWSLIWIW F*NSSVQ*MGLRI*RP*CLGHSLVRMSMLRSQML YF*LPESHRIG*EPDPIL*IRKQGWRPFPAAII GSL*GSWRLRKELVCFRIRLLLLSSSVFSQSSA LFHTSEPLQRKH*QE*DKAELQCPLRLPHIFLNI IFQVTRAGTAETAAHPPHPSSSAKP**E*SHRS CLR*TQPLSHTWKPLPLHIVLGFFFLKR*GAEV CGFLILRIYNGKHTTDAQASSPTPQQIPRRQRGR QCRQ*IGLQFYSQEEISC*NHQWVPQATCL*TW GFAMFDLVTYLLFYKMNSLYL*FGGQ*KVQCRN CCCRARWSHGGARRDSGKPVHLN*S*RELSQHSG HQEGQIPQKLPFAQRTCSVFGAFPPTNPDCFCY LRALVPGYCHRIGAGGGGAYF*IK*LFKVGGFL KN*EKGKLFCIAPFHNLIHFLTFSCDFRN*TIVC PVVSWLSCRSAASSGGFGTPVSVAALPVGGAQR AAGTGVCTHLFGLFCS*CCKLYGFLKTISCFYL VLEIQYTFLIQS

Frame 1

GRAGLGWSSGGRGSRACSEGPAEARGREGGKGS AALSPPLPLTLGEEMAAERGARRLLSTPSFWLY CLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPF YFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEW KKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKH NKPDEGYYQCVATVESLGTIISRTAKLIVAGLPR FTSQPEPSSVYAGNNAILNCEVNADLVPFVRWE QNRQPLLLDDRVIKLPSGMLVISNATEGDGGLY RCVVESGGPPKYSDEVELKVLPDPEVISDLVFLK QPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNE EALDTESSERLVLLAGGSLEISDVTEDDAGTYF CIADNGNETIEAQAELTVQAQPEFLKQPTNIYAH ESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDY FKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNA QAGAQLIILEHAPATTGPLPSAPRDVVASLVSTR FIKLTWRTPASDPHGDNLTYSVFYTKEGIARER VENTSHPGEMQVTIQNLMPATVYIFRVMAQNKH GSGESSAPLRVETQPEVQLPGPAPNLRAYAASPT SITVTWETPVSGNGEIQNYKLYYMEKGTDKEQD VDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGV STPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIH WQPPAPATQNGQITGYKIRYRKASRKSDVTETL VSGTQLSQLIEGLDRGTEYNFRVAALTINGTGP ATDWLSAETFESDLDETRVPEVPSSLHVRPLVTS IVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIK VDYKQRYYTIENLDPSSHYVITLKAFNNVGEGI PLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTP MMPPVGVQASILSHDTIRITWADNSLPKHQKIT DSRYYTVRWKTNIPANTKYKNANATTLSYLVTG LKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELV PTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGK ITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQI QELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPK ADSSDKMPNDQASGSGGKGSRLPDLGSDYKPPM SGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVV VVIIAVFCTRRTTSHQKKKRAACKSVNGSHKYKG NSKDVKPPDLWIHHERLELKPIDKSPDPNPIMT DTPIPRNSQDITPVDNSMDSNIHQRRNSYRGHE SEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAH PIHSLDNPHHHFHSSSLASPARSHLYHPGSPWP IGTSMSLSDRANSTESVRNTPSTDTMPASSSQT CCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHV RPSHPLKSFAVPAIPPPGPPTYDPALPSTPLLS QQALNHHIHSVKTASIGTLGRSRPPMPVVVPSA PEVQETTRMLEDSESSYEPDELTKEMAHLEGLMK DLNAITTA*RPSPGPDFKPESGSLGTYP*KQGI VQSTRGQHLRTQNEPADWPAPLCRAGSRHGHLP SPGQPGRSLCRGSFPLPADILQDWAPWAKILCPG KRREVQPAFHFVVRPCLCAVTASPLWSVDIGIY VQFYLCLILFYLQKQKRHPKPRKSLVFSTSG*H LTACSNYVWKVFDSVGRSWGWLVFWFHFYFLILS HCILYQLLIHHSEGEEMLHCCL*AFFIIFLL*L LKA*LFPLITVRLQIYLN*MKCNIEKTCLLLSV QFQYWGGWGAGGW**EMEGLLRSCECFCHCTFFQ KPAENGSIFFIVLSWHVHPYCHYVATGV*FGSG FKILLCNRWV*GFSGPDVLVIAW*ECPC*GARC CISNCLSHTE*GKSLTPFCKSESKDGDPFLLLLL ALFEEVGG*GRNLFVSVYDSFFSLVQSSASPAL SSTLQSPFRESISRNETRQSCSAP*GFHTSF*I LFFK*QGQGQRKQLPTPPIPAAQLSPDENEATGV V*GEPSRSATHGSHCLCT*FLGSFS*KGKELRC VVF*Y*EYIMENTRLTLRHLPLLPNRSPEDSVE GSVDSKSGFSSIAKKRSAAETTSGYPRPPAFELG DLPCLILSHTCFFTR*TLCIYDLGGNERCNAGT AAAELAGHMGVPGGILENQCT*TDPEESCPSTL ATRRARFPRNYLLPKEHAQYLGHFLPQTLTASVT SGPWYLDTATELGRVGEGPIFK*NNCSKLGVF* KIKKKESYSVLHLFTI*YIFLHFPVIFETKPLC VL*CPG*AAAQQLPRGDLEHLCLSPHCLWEGPRG LLGLASVHTCLAFSVVDAVNSMAF*KRFHVFI* YWKSNTLF*SNQ

Frame 2

AGPGWAGAAAAAGAELAARDRLRRAGGKEARAP RRCRRRCRSLSGKRWRRSGEPGDSSAPPPSGST ACCCSGAGRRAPRPPGAAPRRSPQEPAFERSLH FIFWWSRWIHSQLEALLLY*TVQHILSLLQKLNG KKMELF*T*YQMIDASFSRMDLYLSAMWCIPNT INLMKVIISVWPLLRVLELLSVEQRSS**QVFQ DLPANQNLPQFMLGTMQF*IVKLMQIWSHL*GGN RTDNPFFWMIELSNFQVECWLSAMQLKEMAGFI AA*WKVVGHQSIVMKLN*RFFQILR*YQTWYF* NSLLP*SESLVRM*CCHVLLQDFLLQPLNG*KMR RHLTQKALKDWYCWQVVAWRSVMLLRMMLGLIF V*LIMEMRQLKLKQSLQCKLNLNS*SSLLIYML TNLWILYLNVK*LENQLQL*SGSKMGIWLSQVII LRL*RNIIFKFWVW*NQMKGSISALLKMMLEMH KLEPN**SLNMHQPQRDHCLQLLGMSWPPWSLP ASSN*RGGHLHQILTETTLPTLCSTPRKGLLGNV LRIPVTQERCK*PFKT*CQRPCTSLELWLKISM AQERVQLHCE*KHNLRFSSLAQHLTFVHMQLRL PPSLLRGKHQCLAMGKFRIINCTTWKRGLIKNRM LMFQVTLTPLMG*KNIQSIVSEWWPTINMVLEF PHQMLLFEHCQMFPVLLLRICPWK*EIQRVL*F TGSHLLQPHKMGRLLATRFATERPPERVMSLRPW *AGHSCLS*LKVLIGGLSIISEWLL*QSMVQAR QLTGCLLKLLKVT*MKLVFLKCLALFTYARSLL AS**AGLLQRIRTLWSEVTPLVMALAALMPRPSK WTINSAITPLKIWIPALTM*LP*KHLITWVKAS PCMRVL*PGLTQTLLKLIYLLLMLHTLQCQIPL P*CHQWEFRLPF*VMTPSGLRGQTTRCPSTRRLQ TPDTTPSDGKPTSQQTPSTRMQMQPL*VIW*LV *SRIHSMNSL*W*PKVEDQVHGV*QPMGPPLN* FRLLHPRM*LL*VKRGNLRP*L*IGSLPPKPMAK LQVTSYITVQM*MQRYMTGLLSLLWETD*LTRY KS*LLTHHTTSKSRHGTQRAWDPCLKLSNSEHL KRTPLIKCLMIKPQGLEGKEAGCQT*DPTTNLQ* AAVTALMGAPPLLWTVICCWS*LFLLASSPSWW L*LSLSFVPVVPPLTRKRNELPANQ*MALISTK GIPKM*NLQISGSIMRDWS*NPLISLQTQTPS*L ILQFLATLKISHQLTTPWTAISIKGEIHTEGMS QRTACLHWLEGEE*DQK**CPLTPSHPSL*LVP IPSIPSITLTIISTPAASLLQLAVISTTRAAHGP LAHPCPFQTGPIPQNPFEIPPALTPCQPLRLKH AALITRTLKVLPAPLTWPAPKRKIQARVFPLPM FALPTH*RASPCQQSRLQDLPPMILHCQAHHYCP SKL*TITFTQ*RQPPSGL*EGAGLLCQWLFPVP LKCRRPQGCWKTPRVAMNQMS*PKRWPTWKD** RT*TLSQQHDDLHQDLTSNLSLEVLELTLENKEL YRVREDST*EHRMSQQTGQRLCVGLAPGMATCL PLVSLEEACVEAASLCLLIFCRTGHHGPKFCVQ GRGEKCNLHFTLWSGRVFVL*LHHLYGV*TLAFM YNFICVLFYFTFKNKNAIQNQGSPWCSPQVVDI *LLVPIMYGKSLTVWVVPGVGLFFGFIFIF*F* VIASSTSC*SITLRGRKCCIAVCKLFLLFFYYNY *RPDSFLSSL*DYRSI*IE*NVTLKRLVCCFLC SFSIGAGGGLGVGNRKWRGC*GPVNVSVIVLSS RSLQRMEASSLLSFPGMSILIVTTLQLEFDLDLV LKFFCAIDGFEDLAALMSWS*PGKNVHAEEPDV VFLTA*VTQNRVRA*PHSVNQKARMETLSCCYY WLSLRKLEVKEGTCLFPYTTPSSL*FSLQPVQRS LPHFRAPSEKALAGMRQGRAAVPPEASTHLSEY YFSSNKGRDSGNSCPPPPSQQLS*ALMRMKPQE LSEVNPAAQPHMEAIAFAHSSWVLFPKKVRS*GV WFFNIKNI*WKTHD*RSGIFPYSPTDPQKTAWK AV*TVNRASVL*PRRDQLLKPPVGTPGHLPLNL GICHV*SCHILAFLQDELFVFMIWGAMKGAMQEL LLPSSLVTWGCQAGFWKTSALKLILKRAVPALW PPGGPDSPETTFCPKNMLSIWGISSHKP*LLLL PQGLGTWILPQNWGGWGRGLFLNKITVQSWGFFK KLRKRKAILYCTFSQFNTFSYIFL*FSKLNHCV SCSVLVELPLSSFLGGIWNTCVCRRTACGRGPE GCWDWRLYTLVWPFL*LML*TLWLFKNDFMFLFS IGNPIHFFNPIK

Sequence NEO1.bAug05

GGAAATGAGACAATTGAAGCTCAAGCAGAGCTTACAGTGCAAGCTCAACCTGAATTCCTGAAGCAGCCTACTAATATATATGCTCACGAATCTATGGATA TTGTATTTGAATGTGAAGTGACTGGAAAACCAACTCCAACTGTGAAGTGGGTCAAAAATGGGGATATGGTTATCCCAAGTGATTATTTTAAGATTGTAAA GGAACATAATCTTCAAGTTTTGGGTCTGGTGAAATCAGATGAAGGGTTCTATCAGTGCATTGCTGAAAATGATGTTGGAAATGCACAAGCTGGAGCCCAA CTGATAATCCTTGAACATGATGTTGCCATCCCAACATTACCTCCCACTTCACTGACCAGTGCCACTACTGACCATCTAGCACCAGCCACAACGGGACCAC TGCCTTCAGCTCCTCGGGATGTCGTGGCCTCCCTGGTCTCTACCCGCTTCATCAAATTGACGTGGCGGACACCTGCATCAGATCCTCACGGAGACAACCT TACCTACTCTGTGTTCTACACCAAGGAAGGGATTGCTAGGGAACGTGTTGAGAATACCAGTCACCCAGGAGAGATGCAAGTAACCATTCAAAACCTAATG CCAGCGACCGTGTACATCTTTAGAGTTATGGCTCAAAATAAGCATGGCTCAGGAGAGAGTTCAGCTCCACTGCGAGTAGAAACACAACCTGAGGTTCAGC TCCCTGGCCCAGCACCTAACCTTCGTGCATATGCAGCTTCGCCTACCTCCATCACTGTTACGTGGGAAACACCAGTGTCTGGCAATGGGGAAATTCAGAA TTATAAATTGTACTACATGGAAAAGGGGACTGATAAAGAACAGGATGTTGATGTTTCAAGTCACTCTTACACCATTAATGGGTTGAAAAAATATACAGAG TATAGTTTCCGAGTGGTGGCCTACAATAAACATGGTCCTGGAGTTTCCACACCAGATGTTGCTGTTCGAACATTGTCAGATGTTCCCAGTGCTGCTCCTC AGAATCTGTCCTTGGAAGTGAGAAATTCAAAGAGTATTATGATTCACTGGCAGCCACCTGCTCCAGCCACACAAAATGGGCAGATTACTGGCTACAAGAT TCGCTACCGAAAGGCCTCCCGAAAGAGTGATGTCACTGAGACCTTGGTAAGCGGGACACAGCTGTCTCAGCTGATTGAAGGTCTTGATCGGGGGACTGAG TATAATTTCCGAGTGGCTGCTCTAACAATCAATGGTACAGGCCCGGCAACTGACTGGCTGTCTGCTGAAACTTTTGAAAGTGACCTAGATGAAACTCGTG TTCCTGAAGTGCCTAGCTCTCTTCACGTACGCCCGCTCGTTACTAGCATCGTAGTGAGCTGGACTCCTCCAGAGAATCAGAACATTGTGGTCAGAGGTTA CGCCATTGGTTATGGCATTGGCAGCCCTCATGCCCAGACCATCAAAGTGGACTATAAACAGCGCTATTACACCATTGAAAATCTGGATCCCAGCTCTCAC TATGTGATTACCCTGAAAGCATTTAATAACGTGGGTGAAGGCATCCCCCTGTATGAGAGTGCTGTGACCAGGCCTCACACAGTGCCAGATCCCACTCCCA TGATGCCACCAGTGGGAGTTCAGGCTTCCATTCTGAGTCATGACACCATCAGGATTACGTGGGCAGACAACTCGCTGCCCAAGCACCAGAAGATTACAGA CTCCCGATACTACACCGTCCGATGGAAAACCAACATCCCAGCAAACACCAAGTACAAGAATGCAAATGCAACCACTTTGAGTTATTTGGTGACTGGTTTA AAGCCGAATACACTCTATGAATTCTCTGTGATGGTGACCAAAGGTCGAAGATCAAGTACATGGAGTATGACAGCCCATGGGACCACCTTTGAATTAGTTC CGACTTCTCCACCCAAGGATGTGACTGTTGTGAGTAAAGAGGGGAAACCTAAGACCATAATTGTGAATTGGCAGCCTCCCTCCGAAGCCAATGGCAAAAT TACAGGTTACATCATATATTACAGTACAGATGTGAATGCAGAGATACATGACTGGGTTATTGAGCCTGTTGTGGGAAACAGACTGACTCACCAGATACAA GAGTTAACTCTTGACACACCATACTACTTCAAAATCCAGGCACGGAACTCAAAGGGCATGGGACCCATGTCTGAAGCTGTCCAATTCAGAACACCTAAAG CCTCAGGGTCTGGAGGGAAAGGAAGCCGGCTGCCAGACCTAGGATCCGACTACAAACCTCCAATGAGCGGCAGTAACAGCCCTCATGGGAGCCCCACCTC TCCTCTGGACAGTAATATGCTGCTGGTCATAATTGTTTCTGTTGGCGTCATCACCATCGTGGTGGTTGTGATTATCGCTGTCTTTTGTACCCGTCGTACC ACCTCTCACCAGAAAAAGAAACGAGCTGCCTGCAAATCAGTGAATGGCTCTCATAAGTACAAAGGGAATTCCAAAGATGTGAAACCTCCAGATCTCTGGA TCCATCATGAGAGACTGGAGCTGAAACCCATTGATAAGTCTCCAGACCCAAACCCCATCATGACTGATACTCCAATTCCTCGCAACTCTCAAGATATCAC ACCAGTTGACAACTCCATGGACAGCAATATCCATCAAAGGCGAAATTCATACAGAGGGCATGAGTCAGAGGACAGCATGTCTACACTGGCTGGAAGGCGA GGAATGAGACCAAAAATGATGATGCCCTTTGACTCCCAGCCACCCCAGCCTGTGATTAGTGCCCATCCCATCCATTCCCTCGATAACCCTCACCATCATT TCCACTCCAGCAGCCTCGCTTCTCCAGCTCGCAGTCATCTCTACCACCCGGGCAGCCCATGGCCCATTGGCACATCCATGTCCCTTTCAGACAGGGCCAA TTCCACAGAATCCGTTCGAAATACCCCCAGCACTGACACCATGCCAGCCTCTTCGTCTCAAACATGCTGCACTGATCACCAGGACCCTGAAGGTGCTACC AGCTCCTCTTACTTGGCCAGCTCCCAAGAGGAAGATTCAGGCCAGAGTCTTCCCACTGCCCATGTTCGCCCTTCCCACCCATTGAAGAGCTTCGCCGTGC CAGCAATCCCGCCTCCAGGACCTCCCACCTATGATCCTGCATTGCCAAGCACACCATTACTGTCCCAGCAAGCTCTGAACCATCACATTCACTCAGTGAA GACAGCCTCCATCGGGACTCTAGGAAGGAGCCGGCCTCCTATGCCAGTGGTTGTTCCCAGTGCCCCTGAAGTGCAGGAGACCACAAGGATGTTGGAAGAC TCCGAGAGTAGCTATGAACCAGATGAGCTGACCAAAGAGATGGCCCACCTGGAAGGACTAATGAAGGACCTAAACGCTATCACAACAGCATGACGACCTT CACCAGGACCTGACTTCAAACCTGAGTCTGGAAGTCTTGGAACTTACCCTTGAAAACAAGGAATTGTACAGAGTACGAGAGGACAGCACTTGAGAACACA GAATGAGCCAGCAGACTGGCCAGCGCCTCTGTGTAGGGCTGGCTCCAGGCATGGCCACCTGCCTTCCCCTGGTCAGCCTGGAAGAAGCCTGTGTCGAGGC AGCTTCCCTTTGCCTGCTGATATTCTGCAGGACTGGGCACCATGGGCCAAAATTTTGTGTCCAGGGAAGAGGCGAGAAGTGCAACCTGCATTTCACTTTG TGGTCAGGCCGTGTCTTTGTGCTGTGACTGCATCACCTTTATGGAGTGTAGACATTGGCATTTATGTACAATTTTATTTGTGTCTTATTTTATTTTACCT TCAAAAACAAAAACGCCATCCAAAACCAAGGAAGTCCTTGGTGTTCTCCACAAGTGGTTGACATTTGACTGCTTGTTCCAATTATGTATGGAAAGTCTTT GACAGTGTGGGTCGTTCCTGGGGTTGGCTTGTTTTTTGGTTTCATTTTTATTTTTTAATTCTGAGTCATTGCATCCTCTACCAGCTGTTAATCCATCACT CTGAGGGGGAGGAAATGTTGCATTGCTGTTTGTAAGCTTTTTTTATTATTTTTTTATTATAATTATTAAAGGCCTGACTCTTTCCTCTCATCACTGTGAG ATTACAGATCTATTTGAATTGAATGAAATGTAACATTGAAAAGACTTGTTTGTTGCTTTCTGTGCAGTTTCAGTATTGGGGCGGGTGGGGGGCTGGGGGT TGGTAATAGGAAATGGAGGGGCTGCTGAGGTCCTGTGAATGTTTCTGTCATTGTACTTTCTTCCAGAAGCCTGCAGAGAATGGAAGCATCTTCTTTATTG TCCTTTCCTGGCATGTCCATCCTTATTGTCACTACGTTGCAACTGGAGTTTGATTTGGATCTGGTTTTAAAATTCTTCTGTGCAATAGATGGGTTTGAGG ATTTAGCGGCCCTGATGTCTTGGTCATAGCCTGGTAAGAATGTCCATGCTGAGGAGCCAGATGTTGTATTTCTAACTGCCTGAGTCACACAGAATAGGGT AAGAGCCTGACCCCATTCTGTAAATCAGAAAGCAAGGATGGAGACCCTTTCCTGCTGCTATTATTGGCTCTCTTTGAGGAAGTTGGAGGTTAAGGAAGGA ACTTGTTTGTTTCCGTATACGACTCCTTCTTCTCTCTAGTTCAGTCTTCAGCCAGTCCAGCGCTCTCTTCCACACTTCAGAGCCCCTTCAGAGAAAGCAT TAGCAGGAATGAGACAAGGCAGAGCTGCAGTGCCCCCTGAGGCTTCCACACATCTTTCTGAATATTATTTTTCAAGTAACAAGGGCAGGGACAGCGGAAA CAGCTGCCCACCCCCCCCATCCCAGCAGCTCAGCTAAGCCCTGATGAGAATGAAGCCACAGGAGTTGTCTGAGGTGAACCCAGCCGCTCAGCCACACATG GAAGCCATTGCCTTTGCACATAGTTCTTGGGTTCTTTTTCCTAAAAAGGTAAGGAGCTGAGGTGTGTGGTTTTTTAATATTAAGAATATATAATGGAAAA CACACGACTGACGCTCAGGCATCTTCCCCTACTCCCCAACAGATCCCCAGAAGACAGCGTGGAAGGCAGTGTAGACAGTAAATCGGGCTTCAGTTCTATA GCCAAGAAGAGATCAGCTGCTGAAACCACCAGTGGGTACCCCAGGCCACCTGCCTTTGAACTTGGGGATTTGCCATGTTTGATCTTGTCACATACTTGCT TTTTTACAAGATGAACTCTTTGTATTTATGATTTGGGGGGCAATGAAAGGTGCAATGCAGGAACTGCTGCTGCCGAGCTCGCTGGTCACATGGGGGTGCC AGGCGGGATTCTGGAAAACCAGTGCACTTAAACTGATCCTGAAGAGAGCTGTCCCAGCACTCTGGCCACCAGGAGGGCCAGATTCCCCAGAAACTACCTT TTGCCCAAAGAACATGCTCAGTATTTGGGGCATTTCCTCCCACAAACCCTGACTGCTTCTGTTACCTCAGGGCCTTGGTACCTGGATACTGCCACAGAAT TGGGGCGGGTGGGGGAGGGGCCTATTTTTAAATAAAATAACTGTTCAAAGTTGGGGGTTTTTTAAAAAATTAAGAAAAAGGAAAGCTATTCTGTATTGCA CCTTTTCACAATTTAATACATTTTCTTACATTTTCCTGTGATTTTCGAAACTAAACCATTGTGTGTCCTGTAGTGTCCTGGTTGAGCTGCCGCTCAGCAG CTTCCTCGGGGGGATTTGGAACACCTGTGTCTGTCGCCGCACTGCCTGTGGGAGGGGCCCAGAGGGCTGCTGGGACTGGCGTCTGTACACACTTGTTTGG CCTTTTCTGTAGTTGATGCTGTAAACTCTATGGCTTTTTAAAAACGATTTCATGTTTTTATTTAGTATTGGAAATCCAATACACTTTTTTAATCCAATCA AA

NEO1.u.f.8 (forward primer)
NEO1.u.r.13 (reverse primer)
Alternative acceptor

Frame 0

GNETIEAQAELTVQAQPEFLKQPTNIYAHESMD IVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVK EHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQ LIILEHDVAIPTLPPTSLTSATTDHLAPATTGP LPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNL TYSVFYTKEGIARERVENTSHPGEMQVTIQNLM PATVYIFRVMAQNKHGSGESSAPLRVETQPEVQ LPGPAPNLRAYAASPTSITVTWETPVSGNGEIQN YKLYYMEKGTDKEQDVDVSSHSYTINGLKKYTE YSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAP QNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKI RYRKASRKSDVTETLVSGTQLSQLIEGLDRGTE YNFRVAALTINGTGPATDWLSAETFESDLDETR VPEVPSSLHVRPLVTSIVVSWTPPENQNIVVRGY AIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSH YVITLKAFNNVGEGIPLYESAVTRPHTVPDPTP MMPPVGVQASILSHDTIRITWADNSLPKHQKITD SRYYTVRWKTNIPANTKYKNANATTLSYLVTGL KPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELV PTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKI TGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQ ELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPK ASGSGGKGSRLPDLGSDYKPPMSGSNSPHGSPTS PLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRT TSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLW IHHERLELKPIDKSPDPNPIMTDTPIPRNSQDIT PVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRR GMRPKMMMPFDSQPPQPVISAHPIHSLDNPHHH FHSSSLASPARSHLYHPGSPWPIGTSMSLSDRAN STESVRNTPSTDTMPASSSQTCCTDHQDPEGAT SSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAV PAIPPPGPPTYDPALPSTPLLSQQALNHHIHSVK TASIGTLGRSRPPMPVVVPSAPEVQETTRMLED SESSYEPDELTKEMAHLEGLMKDLNAITTA*RP SPGPDFKPESGSLGTYP*KQGIVQSTRGQHLRTQ NEPADWPAPLCRAGSRHGHLPSPGQPGRSLCRG SFPLPADILQDWAPWAKILCPGKRREVQPAFHF VVRPCLCAVTASPLWSVDIGIYVQFYLCLILFYL QKQKRHPKPRKSLVFSTSG*HLTACSNYVWKVF DSVGRSWGWLVFWFHFYFLILSHCILYQLLIHH SEGEEMLHCCL*AFFIIFLL*LLKA*LFPLITVR LQIYLN*MKCNIEKTCLLLSVQFQYWGGWGAGG W**EMEGLLRSCECFCHCTFFQKPAENGSIFFI VLSWHVHPYCHYVATGV*FGSGFKILLCNRWV*G FSGPDVLVIAW*ECPC*GARCCISNCLSHTE*G KSLTPFCKSESKDGDPFLLLLLALFEEVGG*GR NLFVSVYDSFFSLVQSSASPALSSTLQSPFRESI SRNETRQSCSAP*GFHTSF*ILFFK*QGQGQRK QLPTPPIPAAQLSPDENEATGVV*GEPSRSATH GSHCLCT*FLGSFS*KGKELRCVVF*Y*EYIMEN TRLTLRHLPLLPNRSPEDSVEGSVDSKSGFSSI AKKRSAAETTSGYPRPPAFELGDLPCLILSHTC FFTR*TLCIYDLGGNERCNAGTAAAELAGHMGVP GGILENQCT*TDPEESCPSTLATRRARFPRNYL LPKEHAQYLGHFLPQTLTASVTSGPWYLDTATE LGRVGEGPIFK*NNCSKLGVF*KIKKKESYSVLH LFTI*YIFLHFPVIFETKPLCVL*CPG*AAAQQ LPRGDLEHLCLSPHCLWEGPRGLLGLASVHTCL AFSVVDAVNSMAF*KRFHVFI*YWKSNTLF*SNQ

Frame 1

EMRQLKLKQSLQCKLNLNS*SSLLIYMLTNLWI LYLNVK*LENQLQL*SGSKMGIWLSQVIILRL* RNIIFKFWVW*NQMKGSISALLKMMLEMHKLEPN **SLNMMLPSQHYLPLH*PVPLLTI*HQPQRDH CLQLLGMSWPPWSLPASSN*RGGHLHQILTETT LPTLCSTPRKGLLGNVLRIPVTQERCK*PFKT*C QRPCTSLELWLKISMAQERVQLHCE*KHNLRFS SLAQHLTFVHMQLRLPPSLLRGKHQCLAMGKFR IINCTTWKRGLIKNRMLMFQVTLTPLMG*KNIQS IVSEWWPTINMVLEFPHQMLLFEHCQMFPVLLL RICPWK*EIQRVL*FTGSHLLQPHKMGRLLATR FATERPPERVMSLRPW*AGHSCLS*LKVLIGGLS IISEWLL*QSMVQARQLTGCLLKLLKVT*MKLV FLKCLALFTYARSLLAS**AGLLQRIRTLWSEV TPLVMALAALMPRPSKWTINSAITPLKIWIPALT M*LP*KHLITWVKASPCMRVL*PGLTQCQIPLP *CHQWEFRLPF*VMTPSGLRGQTTRCPSTRRLQ TPDTTPSDGKPTSQQTPSTRMQMQPL*VIW*LV* SRIHSMNSL*W*PKVEDQVHGV*QPMGPPLN*F RLLHPRM*LL*VKRGNLRP*L*IGSLPPKPMAK LQVTSYITVQM*MQRYMTGLLSLLWETD*LTRYK S*LLTHHTTSKSRHGTQRAWDPCLKLSNSEHLK PQGLEGKEAGCQT*DPTTNLQ*AAVTALMGAPP LLWTVICCWS*LFLLASSPSWWL*LSLSFVPVVP PLTRKRNELPANQ*MALISTKGIPKM*NLQISG SIMRDWS*NPLISLQTQTPS*LILQFLATLKIS HQLTTPWTAISIKGEIHTEGMSQRTACLHWLEGE E*DQK**CPLTPSHPSL*LVPIPSIPSITLTII STPAASLLQLAVISTTRAAHGPLAHPCPFQTGP IPQNPFEIPPALTPCQPLRLKHAALITRTLKVLP APLTWPAPKRKIQARVFPLPMFALPTH*RASPC QQSRLQDLPPMILHCQAHHYCPSKL*TITFTQ* RQPPSGL*EGAGLLCQWLFPVPLKCRRPQGCWKT PRVAMNQMS*PKRWPTWKD**RT*TLSQQHDDL HQDLTSNLSLEVLELTLENKELYRVREDST*EH RMSQQTGQRLCVGLAPGMATCLPLVSLEEACVEA ASLCLLIFCRTGHHGPKFCVQGRGEKCNLHFTL WSGRVFVL*LHHLYGV*TLAFMYNFICVLFYFT FKNKNAIQNQGSPWCSPQVVDI*LLVPIMYGKSL TVWVVPGVGLFFGFIFIF*F*VIASSTSC*SIT LRGRKCCIAVCKLFLLFFYYNY*RPDSFLSSL* DYRSI*IE*NVTLKRLVCCFLCSFSIGAGGGLGV GNRKWRGC*GPVNVSVIVLSSRSLQRMEASSLL SFPGMSILIVTTLQLEFDLDLVLKFFCAIDGFE DLAALMSWS*PGKNVHAEEPDVVFLTA*VTQNRV RA*PHSVNQKARMETLSCCYYWLSLRKLEVKEG TCLFPYTTPSSL*FSLQPVQRSLPHFRAPSEKA LAGMRQGRAAVPPEASTHLSEYYFSSNKGRDSGN SCPPPPSQQLS*ALMRMKPQELSEVNPAAQPHM EAIAFAHSSWVLFPKKVRS*GVWFFNIKNI*WK THD*RSGIFPYSPTDPQKTAWKAV*TVNRASVL* PRRDQLLKPPVGTPGHLPLNLGICHV*SCHILA FLQDELFVFMIWGAMKGAMQELLLPSSLVTWGC QAGFWKTSALKLILKRAVPALWPPGGPDSPETTF CPKNMLSIWGISSHKP*LLLLPQGLGTWILPQN WGGWGRGLFLNKITVQSWGFFKKLRKRKAILYC TFSQFNTFSYIFL*FSKLNHCVSCSVLVELPLSS FLGGIWNTCVCRRTACGRGPEGCWDWRLYTLVW PFL*LML*TLWLFKNDFMFLFSIGNPIHFFNPI K

Frame 2

K*DN*SSSRAYSASST*IPEAAY*YICSRIYGY CI*M*SDWKTNSNCEVGQKWGYGYPK*LF*DCK GT*SSSFGSGEIR*RVLSVHC*K*CWKCTSWSP TDNP*T*CCHPNITSHFTDQCHY*PSSTSHNGTT AFSSSGCRGLPGLYPLHQIDVADTCIRSSRRQP YLLCVLHQGRDC*GTC*EYQSPRRDASNHSKPN ASDRVHL*SYGSK*AWLRREFSSTASRNTT*GSA PWPST*PSCICSFAYLHHCYVGNTSVWQWGNSE L*IVLHGKGD**RTGC*CFKSLLHH*WVEKIYR V*FPSGGLQ*TWSWSFHTRCCCSNIVRCSQCCSS ESVLGSEKFKEYYDSLAATCSSHTKWADYWLQD SLPKGLPKE*CH*DLGKRDTAVSAD*RS*SGD* V*FPSGCSNNQWYRPGN*LAVC*NF*K*PR*NSC S*SA*LSSRTPARY*HRSELDSSRESEHCGQRL RHWLWHWQPSCPDHQSGL*TALLHH*KSGSQLS LCDYPESI**RG*RHPPV*ECCDQASHSARSHSH DATSGSSGFHSES*HHQDYVGRQLAAQAPEDYR LPILHRPMENQHPSKHQVQECKCNHFELFGDWF KAEYTL*ILCDGDQRSKIKYMEYDSPWDHL*ISS DFSTQGCDCCE*RGET*DHNCELAASLRSQWQN YRLHHILQYRCECRDT*LGY*ACCGKQTDSPDT RVNS*HTILLQNPGTELKGHGTHV*SCPIQNT*S LRVWRERKPAARPRIRLQTSNERQ*QPSWEPHL SSGQ*YAAGHNCFCWRHHHRGGCDYRCLLYPSY HLSPEKETSCLQISEWLS*VQREFQRCETSRSLD PS*ETGAETH**VSRPKPHHD*YSNSSQLSRYH TS*QLHGQQYPSKAKFIQRA*VRGQHVYTGWKA RNETKNDDAL*LPATPACD*CPSHPFPR*PSPSF PLQQPRFSSSQSSLPPGQPMAHWHIHVPFRQGQ FHRIRSKYPQH*HHASLFVSNMLH*SPGP*RCY QLLLLGQLPRGRFRPESSHCPCSPFPPIEELRRA SNPASRTSHL*SCIAKHTITVPASSEPSHSLSE DSLHRDSRKEPASYASGCSQCP*SAGDHKDVGR LRE*L*TR*ADQRDGPPGRTNEGPKRYHNSMTTF TRT*LQT*VWKSWNLPLKTRNCTEYERTALENT E*ASRLASASV*GWLQAWPPAFPWSAWKKPVSR QLPFAC*YSAGLGTMGQNFVSREEARSATCISLC GQAVSLCCDCITFMECRHWHLCTILFVSYFILP SKTKTPSKTKEVLGVLHKWLTFDCLFQLCMESL *QCGSFLGLACFLVSFLFFNSESLHPLPAVNPSL *GGGNVALLFVSFFYYFFIIIIKGLTLSSHHCE ITDLFELNEM*H*KDLFVAFCAVSVLGRVGGWG LVIGNGGAAEVL*MFLSLYFLPEACREWKHLLYC PFLACPSLLSLRCNWSLIWIWF*NSSVQ*MGLR I*RP*CLGHSLVRMSMLRSQMLYF*LPESHRIG *EPDPIL*IRKQGWRPFPAAIIGSL*GSWRLRKE LVCFRIRLLLLSSSVFSQSSALFHTSEPLQRKH *QE*DKAELQCPLRLPHIFLNIIFQVTRAGTAE TAAHPPHPSSSAKP**E*SHRSCLR*TQPLSHTW KPLPLHIVLGFFFLKR*GAEVCGFLILRIYNGK HTTDAQASSPTPQQIPRRQRGRQCRQ*IGLQFY SQEEISC*NHQWVPQATCL*TWGFAMFDLVTYLL FYKMNSLYL*FGGQ*KVQCRNCCCRARWSHGGA RRDSGKPVHLN*S*RELSQHSGHQEGQIPQKLP FAQRTCSVFGAFPPTNPDCFCYLRALVPGYCHRI GAGGGGAYF*IK*LFKVGGFLKN*EKGKLFCIA PFHNLIHFLTFSCDFRN*TIVCPVVSWLSCRSA ASSGGFGTPVSVAALPVGGAQRAAGTGVCTHLFG LFCS*CCKLYGFLKTISCFYLVLEIQYTFLIQS