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Sequences

Sequence PARK2.cAug05

AGTGTTTGTCAGGTTCAACTCCAGCCATGGTTTCCCAGTGGAGGTCGATTCTGACACCAGCATCTTCCAGCTCAAGGAGGTGGTTGCTAAGCGACAGGGG GTTCCGGCTGACCAGTTGCGTGTGATTTTCGCAGGGAAGGAGCTGAGGAATGACTGGACTGTGCAGAATTGTGACCTGGATCAGCAGAGCATTGTTCACA TTGTGCAGAGACCGTGGAGAAAAGGTCAAGAAATGAATGCAACTGGAGGCGACGACCCCAGAAACGCGGCGGGAGGCTGTGAGCGGGAGCCCCAGAGCTT GACTCGGGTGGACCTCAGCAGCTCAGTCCTCCCAGGAGACTCTGTGGGGCTGGCTGTCATTCTGCACACTGACAGCAGGAAGGACTCACCACCAGCTGGA AGTCCAGGGTCCATCTTGCTGGGATGATGTTTTAATTCCAAACCGGATGAGTGGTGAATGCCAATCCCCACACTGCCCTGGGACTAGTGCAGAATTTTTC TTTAAATGTGGAGCACACCCCACCTCTGACAAGGAAACATCAGTAGCTTTGCACCTGATCGCAACAAATAGTCGGAACATCACTTGCATTACGTGCACAG ACGTCAGGAGCCCCGTCCTGGTTTTCCAGTGCAACTCCCGCCACGTGATTTGCTTAGACTGTTTCCACTTATACTGTGTGACAAGACTCAATGATCGGCA GTTTGTTCACGACCCTCAACTTGGCTACTCCCTGCCTTGTGTGGCTGGCTGTCCCAACTCCTTGATTAAAGAGCTCCATCACTTCAGGATTCTGGGAGAA GAGCAGTACAACCGGTACCAGCAGTATGGTGCAGAGGAGTGTGTCCTGCAGATGGGGGGCGTGTTATGCCCCCGCCCTGGCTGTGGAGCGGGGCTGCTGC CGGAGCCTGACCAGAGGAAAGTCACCTGCGAAGGGGGCAATGGCCTGGGCTGTGGGTTTGCCTTCTGCCGGGAATGTAAAGAAGCGTACCATGAAGGGGA GTGCAGTGCCGTATTTGAAGCCTCAGGAACAACTACTCAGGAGGCTGCATGCACATGAAGTGTCCGCAGCCCCAGTGCAGGCTCGAGTGGTGCTGGAACT GTGGCTGCGAGTGGAACCGCGTCTGCATGGGGGACCACTGGTTCGACGTGTAGCCAGGGCGGCCGGGCGCCCCATCGCCACATCCTGGGGGAGCATACCC AGTGTCTACCTTCATTTTCTAATTCTCTTTTCAAACACACACACACACGCGCGCGCGCGCACACACACTCTTCAAGTTTTTTTCAAAGTCCAACTACAGC CAAATTGCAGAAGAAACTCCTGGATCCCTTTCACTATGTCCATGAAAAACAGCAGAGTAAAATTACAGAAGAAGCTCCTGAATCCCTTTCAGTTTGTCCA CACAAGACAGCAGAGCCATCTGCGACACCACCAACAGGCGTTCTCAGCCTCCGGATGACACAAATACCAGAGCACAGATTCAAGTGCAATCCATGTATCT GTATGGGTCATTCTCACCTGAATTCGAGACAGGCAGAATCAGTAGCTGGAGAGAGAGTTCTCACATTTAATATCCTGCCTTTTACCTTCAGTAAACACCA TGAAGATGCCATTGACAAGGTGTTTCTCTGTAAAATGAACTGCAGTGGGTTCTCCAAACTAGATTCATGGCTTTAACAGTAATGTTCTTATTTAAATTTT CAGAAAGCATCTATTCCCAAAGAACCCCAGGCAATAGTCAAAAACATTTGTTTATCCTTAAGAATTCCATCTATATAAATCGCATTAATGAAATACCAAC TATGCGTAAATCAACTTGTCACAAAGTGAGAAATTATGAAAGTTAATTTGAATGTTGAATGTTTGAATTACAGGGAAGAAATCAAGTTAATGTACTTTCA TTCCCTTTCATGATTTGCAACTTTAGAAAGAAATTGTTTTTCTGAAAGTATCACCAAAAAATCTATAGTTTGATTCTGAGTATTCATTTTGCAACTTGGA GATTTTGCTAATACATTTGGCTCCACTGTAAATTTAATAGATAAAGTGCCTATAAAGGAAACACGTTTAGAAATGATTTCAAAATGATATTCAATCTTAA CAAAAGTGAACATTATTAAATCAGAATCTTTAAAGAGGAGCCTTTCCAGAACTACCAAAATGAAGACACGCCCGACTCTCTCCATCAGAAGGGTTTATAC CCCTTTGGCACACCCTCTCTGTCCAATCTGCAAGTCCCAGGGAGCTCTGCATACCAGGGGTTCCCCAGGAGAGACCTTCTCTTAGGACAGTAAACTCACT AGAATATTCCTTATGTTGACATGGATTGGATTTCAGTTCAATCAAACTTTCAGCTTTTTTTTCAGCCATTCACAACACAATCAAAAGATTAACAACACTG CATGCGGCAAACCGCATGCTCTTACCCACACTACGCAGAAGAGAAAGTACAACCACTATCTTTTGTTCTACCTGTATTGTCTGACTTCTCAGGAAGATCG TGAACATAACTGAGGGCATGAGTCTCACTAGCACATGGAGGCCCTTTTGGATTTAGAGACTGTAAATTATTAAATCGGCAACAGGGCTTCTCTTTTTAGA TGTAGCACTGAAATCCTTGCTGGAGGGAAGAGAGGGGATGAACTCAAGTTTTCCACATCCTGGGACACCTGTCCCTCTTTTCCTAACTGCCTAAGATAAC CCATTTCTTCCAACCATCTGAGGACAGTCCCGTCGTCTCAGAGGCCCTGCACCGGGGAGAGACTGGGCTCTGCAGCAGCCACATCAGCATTCACAGCTTC ATGTGGCTTCACTGTCTGAAAATCTACCGACTCCAACATGGCCCCACGGTGACAACAGACCTGTGACAGGAAGCCCAAAGCTCACATAGAAATGGTGGAC AGATCAAAGTCTCTATAGTAAGGGAAAAAAAGAGAGGTGGCAGGCATGAGCCCCCTGCACCCAGTGGCTCGTGTCCATACTGAGTCCAGACCCTGATCAA GGCCTGACTTAGTGTCACTGGCAGTCCCACTAAATTACACTTCCTTACACTGGCCCGATGCGACAAATCAGGTGGCTCCCTTCTGTCACGTGGAGCACAC AGTGTTTTCCATCATCCATAGCTTTCTTCCTGATGGTGTTTGCATTATTGCGCCTTCCCAATCTGCATGCTGCGTTGGGCTTGCGGTGCCTGAACAAGGT TTGCTCCCATGAGCTCAGGCACCCTAGGATCCCCTGTTAGACTATTAGGCTGTCCAGCATGGTCTCCTTTCCCTTCTTGGTGGTGGTCTTTTCCCTTTCC AGAATAGAACAGTGATTCTTAAAATAAGTTAGAGCAGGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCAC GAGGTCAGGAGTTCAAGACCAGCCTGGCCAAGATGATGAAACCCCGTCTCTATTAAAAATACAAAAATTAGCTGGGCGTGGTGGCAGGCACCTGTAATCC CAGCTTCCTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGGGGCAGAGGTTGCAGTGAGCCGAGATCACGCCACTGAACTCCAGCCTGGGCAACAG AGTGAGACTCTGTCTCAAAAAAAAAAAAAAAACAAAAACAAAAAAGCAAGATCATCCACTACACATGAACATGAATCACAGTATTATTTGCACAGGAAGG GTGTAACAAAATATGAATGTATCAAAAAATAGAAATAAAGTCTTTGCAGAAAAAGTCTGTTTTTCTCTGAAGTGTGTTGAGATTATCTGACAACTCTAAG ATTGTACTTAAATTGTCAATAAAGCATCAAAA

PARK2.u.f.6 (forward primer)
PARK2.u.r.9 (reverse primer)
Single exon skipping

Frame 0

SVCQVQLQPWFPSGGRF*HQHLPAQGGGC*ATG GSG*PVACDFRREGAEE*LDCAEL*PGSAEHCSH CAETVEKRSRNECNWRRRPQKRGGRL*AGAPEL DSGGPQQLSPPRRLCGAGCHSAH*QQEGLTTSW KSRVHLAGMMF*FQTG*VVNANPHTALGLVQNFS LNVEHTPPLTRKHQ*LCT*SQQIVGTSLALRAQ TSGAPSWFSSATPAT*FA*TVSTYTV*QDSMIG SLFTTLNLATPCLVWLAVPTP*LKSSITSGFWEK SSTTGTSSMVQRSVSCRWGACYAPALAVERGCC RSLTRGKSPAKGAMAWAVGLPSAGNVKKRTMKG SAVPYLKPQEQLLRRLHAHEVSAAPVQARVVLEL WLRVEPRLHGGPLVRRVARAAGRPIATSWGSIP SVYLHFLILFSNTHTHARARTHTLQVFFKVQLQ PNCRRNSWIPFTMSMKNSRVKLQKKLLNPFQFVH TRQQSHLRHHQQAFSASG*HKYQSTDSSAIHVS VWVILT*IRDRQNQ*LEREFSHLISCLLPSVNT MKMPLTRCFSVK*TAVGSPN*IHGFNSNVLI*IF RKHLFPKNPRQ*SKTFVYP*EFHLYKSH**NTN YA*INLSQSEKL*KLI*MLNV*ITGKKSS*CTF IPFHDLQL*KEIVFLKVSPKNL*FDSEYSFCNLE ILLIHLAPL*I**IKCL*RKHV*K*FQNDIQS* QK*TLLNQNL*RGAFPELPK*RHARLSPSEGFI PLWHTLSVQSASPRELCIPGVPQERPSLRTVNSL EYSLC*HGLDFSSIKLSAFFSAIHNTIKRLTTL HAANRMLLPTLRRRESTTTIFCSTCIV*LLRKI VNITEGMSLTSTWRPFWI*RL*IIKSATGLLFLD VALKSLLEGREGMNSSFPHPGTPVPLFLTA*DN PFLPTI*GQSRRLRGPAPGRDWALQQPHQHSQL HVASLSENLPTPTWPHGDNRPVTGSPKLT*KWWT DQSLYSKGKKERWQA*APCTQWLVSILSPDPDQ GLT*CHWQSH*ITLPYTGPMRQIRWLPSVTWST QCFPSSIAFFLMVFALLRLPNLHAALGLRCLNKV CSHELRHPRIPC*TIRLSSMVSFPFLVVVFSLS RIEQ*FLK*VRAGRARWLMPVIPALWEAEVGGS RGQEFKTSLAKMMKPRLY*KYKN*LGVVAGTCNP SFLGG*GRRIT*TRGAEVAVSRDHATELQPGQQ SETLSQKKKKNKNKKARSSTTHEHESQYYLHRK GVTKYECIKK*K*SLCRKSLFFSEVC*DYLTTLR LYLNCQ*SIK

Frame 1

VFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQG VPADQLRVIFAGKELRNDWTVQNCDLDQQSIVH IVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSL TRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAG SPGSILLG*CFNSKPDEW*MPIPTLPWD*CRIF L*MWSTPHL*QGNISSFAPDRNK*SEHHLHYVHR RQEPRPGFPVQLPPRDLLRLFPLILCDKTQ*SA VCSRPSTWLLPALCGWLSQLLD*RAPSLQDSGR RAVQPVPAVWCRGVCPADGGRVMPPPWLWSGAAA GA*PEESHLRRGQWPGLWVCLLPGM*RSVP*RG VQCRI*SLRNNYSGGCMHMKCPQPQCRLEWCWN CGCEWNRVCMGDHWFDV*PGRPGAPSPHPGGAYP VSTFIF*FSFQTHTHTRARAHTLFKFFSKSNYS QIAEETPGSLSLCP*KTAE*NYRRSS*IPFSLS TQDSRAICDTTNRRSQPPDDTNTRAQIQVQSMYL YGSFSPEFETGRISSWRESSHI*YPAFYLQ*TP *RCH*QGVSL*NELQWVLQTRFMALTVMFLFKF SESIYSQRTPGNSQKHLFILKNSIYINRINEIPT MRKSTCHKVRNYES*FEC*MFELQGRNQVNVLS FPFMICNFRKKLFF*KYHQKIYSLILSIHFATW RFC*YIWLHCKFNR*SAYKGNTFRNDFKMIFNLN KSEHY*IRIFKEEPFQNYQNEDTPDSLHQKGLY PFGTPSLSNLQVPGSSAYQGFPRRDLLLGQ*TH *NIPYVDMDWISVQSNFQLFFQPFTTQSKD*QHC MRQTACSYPHYAEEKVQPLSFVLPVLSDFSGRS *T*LRA*VSLAHGGPFGFRDCKLLNRQQGFSF* M*H*NPCWREERG*TQVFHILGHLSLFS*LPKIT HFFQPSEDSPVVSEALHRGETGLCSSHISIHSF MWLHCLKIYRLQHGPTVTTDL*QEAQSSHRNGG QIKVSIVREKKRGGRHEPPAPSGSCPY*VQTLIK A*LSVTGSPTKLHFLTLARCDKSGGSLLSRGAH SVFHHP*LSS*WCLHYCAFPICMLRWACGA*TR FAPMSSGTLGSPVRLLGCPAWSPFPSWWWSFPFP E*NSDS*NKLEQAGRGGSCL*SQHFGRPRWVDH EVRSSRPAWPR**NPVSIKNTKISWAWWQAPVI PASWEAEAGESLEPGGQRLQ*AEITPLNSSLGNR VRLCLKKKKKTKTKKQDHPLHMNMNHSIICTGR V*QNMNVSKNRNKVFAEKVCFSLKCVEII*QL* DCT*IVNKASK

Frame 2

CLSGSTPAMVSQWRSILTPASSSSRRWLLSDRG FRLTSCV*FSQGRS*GMTGLCRIVTWISRALFT LCRDRGEKVKK*MQLEATTPETRREAVSGSPRA *LGWTSAAQSSQETLWGWLSFCTLTAGRTHHQLE VQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFF FKCGAHPTSDKETSVALHLIATNSRNITCITCT DVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQ FVHDPQLGYSLPCVAGCPNSLIKELHHFRILGE EQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLL PEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGE CSAVFEASGTTTQEAACT*SVRSPSAGSSGAGT VAASGTASAWGTTGSTCSQGGRAPHRHILGEHT QCLPSFSNSLFKHTHTRARAHTHSSSFFQSPTTA KLQKKLLDPFHYVHEKQQSKITEEAPESLSVCP HKTAEPSATPPTGVLSLRMTQIPEHRFKCNPCI CMGHSHLNSRQAESVAGERVLTFNILPFTFSKHH EDAIDKVFLCKMNCSGFSKLDSWL*Q*CSYLNF QKASIPKEPQAIVKNICLSLRIPSI*IALMKYQ LCVNQLVTK*EIMKVNLNVECLNYREEIKLMYFH SLS*FATLERNCFSESITKKSIV*F*VFILQLG DFANTFGSTVNLIDKVPIKETRLEMISK*YSIL TKVNIIKSESLKRSLSRTTKMKTRPTLSIRRVYT PLAHPLCPICKSQGALHTRGSPGETFS*DSKLT RIFLMLTWIGFQFNQTFSFFFSHSQHNQKINNT ACGKPHALTHTTQKRKYNHYLLFYLYCLTSQEDR EHN*GHESH*HMEALLDLETVNY*IGNRASLFR CSTEILAGGKRGDELKFSTSWDTCPSFPNCLR* PISSNHLRTVPSSQRPCTGERLGSAAATSAFTAS CGFTV*KSTDSNMAPR*QQTCDRKPKAHIEMVD RSKSL**GKKREVAGMSPLHPVARVHTESRP*S RPDLVSLAVPLNYTSLHWPDATNQVAPFCHVEHT VFSIIHSFLPDGVCIIAPSQSACCVGLAVPEQG LLP*AQAP*DPLLDY*AVQHGLLSLLGGGLFPF QNRTVILKIS*SRPGAVAHACNPSTLGGRGGWIT RSGVQDQPGQDDETPSLLKIQKLAGRGGRHL*S QLPGRLRQENHLNPGGRGCSEPRSRH*TPAWAT E*DSVSKKKKKQKQKSKIIHYT*T*ITVLFAQEG CNKI*MYQKIEIKSLQKKSVFL*SVLRLSDNSK IVLKLSIKHQ

Sequence PARK2.bAug05

CAGGTAGATCAATCTACAACAGCTTTTATGTGTATTGCAAAGGCCCCTGTCAAAGAGTGCAGCCGGGAAAACTCAGGGTACAGTGCAGCACCTGCAGGCA GGCAACGCTCACCTTGACCCAGGGTCCATCTTGCTGGGATGATGTTTTAATTCCAAACCGGATGAGTGGTGAATGCCAATCCCCACACTGCCCTGGGACT AGTGCAGAATTTTTCTTTAAATGTGGAGCACACCCCACCTCTGACAAGGAAACATCAGTAGCTTTGCACCTGATCGCAACAAATAGTCGGAACATCACTT GCATTACGTGCACAGACGTCAGGAGCCCCGTCCTGGTTTTCCAGTGCAACTCCCGCCACGTGATTTGCTTAGACTGTTTCCACTTATACTGTGTGACAAG ACTCAATGATCGGCAGTTTGTTCACGACCCTCAACTTGGCTACTCCCTGCCTTGTGTGGCTGGCTGTCCCAACTCCTTGATTAAAGAGCTCCATCACTTC AGGATTCTGGGAGAAGAGCAGTACAACCGGTACCAGCAGTATGGTGCAGAGGAGTGTGTCCTGCAGATGGGGGGCGTGTTATGCCCCCGCCCTGGCTGTG GAGCGGGGCTGCTGCCGGAGCCTGACCAGAGGAAAGTCACCTGCGAAGGGGGCAATGGCCTGGGCTGTGGGTTTGCCTTCTGCCGGGAATGTAAAGAAGC GTACCATGAAGGGGAGTGCAGTGCCGTATTTGAAGCCTCAGGAACAACTACTCAGGCCTACAGAGTCGATGAAAGAGCCGCCGAGCAGGCTCGTTGGGAA GCAGCCTCCAAAGAAACCATCAAGAAAACCACCAAGCCCTGTCCCCGCTGCCATGTACCAGTGGAAAAAAATGGAGGCTGCATGCACATGAAGTGTCCGC AGCCCCAGTGCAGGCTCGAGTGGTGCTGGAACTGTGGCTGCGAGTGGAACCGCGTCTGCATGGGGGACCACTGGTTCGACGTGTAGCCAGGGCGGCCGGG CGCCCCATCGCCACATCCTGGGGGAGCATACCCAGTGTCTACCTTCATTTTCTAATTCTCTTTTCAAACACACACACACACGCGCGCGCGCGCACACACA CTCTTCAAGTTTTTTTCAAAGTCCAACTACAGCCAAATTGCAGAAGAAACTCCTGGATCCCTTTCACTATGTCCATGAAAAACAGCAGAGTAAAATTACA GAAGAAGCTCCTGAATCCCTTTCAGTTTGTCCACACAAGACAGCAGAGCCATCTGCGACACCACCAACAGGCGTTCTCAGCCTCCGGATGACACAAATAC CAGAGCACAGATTCAAGTGCAATCCATGTATCTGTATGGGTCATTCTCACCTGAATTCGAGACAGGCAGAATCAGTAGCTGGAGAGAGAGTTCTCACATT TAATATCCTGCCTTTTACCTTCAGTAAACACCATGAAGATGCCATTGACAAGGTGTTTCTCTGTAAAATGAACTGCAGTGGGTTCTCCAAACTAGATTCA TGGCTTTAACAGTAATGTTCTTATTTAAATTTTCAGAAAGCATCTATTCCCAAAGAACCCCAGGCAATAGTCAAAAACATTTGTTTATCCTTAAGAATTC CATCTATATAAATCGCATTAATGAAATACCAACTATGCGTAAATCAACTTGTCACAAAGTGAGAAATTATGAAAGTTAATTTGAATGTTGAATGTTTGAA TTACAGGGAAGAAATCAAGTTAATGTACTTTCATTCCCTTTCATGATTTGCAACTTTAGAAAGAAATTGTTTTTCTGAAAGTATCACCAAAAAATCTATA GTTTGATTCTGAGTATTCATTTTGCAACTTGGAGATTTTGCTAATACATTTGGCTCCACTGTAAATTTAATAGATAAAGTGCCTATAAAGGAAACACGTT TAGAAATGATTTCAAAATGATATTCAATCTTAACAAAAGTGAACATTATTAAATCAGAATCTTTAAAGAGGAGCCTTTCCAGAACTACCAAAATGAAGAC ACGCCCGACTCTCTCCATCAGAAGGGTTTATACCCCTTTGGCACACCCTCTCTGTCCAATCTGCAAGTCCCAGGGAGCTCTGCATACCAGGGGTTCCCCA GGAGAGACCTTCTCTTAGGACAGTAAACTCACTAGAATATTCCTTATGTTGACATGGATTGGATTTCAGTTCAATCAAACTTTCAGCTTTTTTTTCAGCC ATTCACAACACAATCAAAAGATTAACAACACTGCATGCGGCAAACCGCATGCTCTTACCCACACTACGCAGAAGAGAAAGTACAACCACTATCTTTTGTT CTACCTGTATTGTCTGACTTCTCAGGAAGATCGTGAACATAACTGAGGGCATGAGTCTCACTAGCACATGGAGGCCCTTTTGGATTTAGAGACTGTAAAT TATTAAATCGGCAACAGGGCTTCTCTTTTTAGATGTAGCACTGAAATCCTTGCTGGAGGGAAGAGAGGGGATGAACTCAAGTTTTCCACATCCTGGGACA CCTGTCCCTCTTTTCCTAACTGCCTAAGATAACCCATTTCTTCCAACCATCTGAGGACAGTCCCGTCGTCTCAGAGGCCCTGCACCGGGGAGAGACTGGG CTCTGCAGCAGCCACATCAGCATTCACAGCTTCATGTGGCTTCACTGTCTGAAAATCTACCGACTCCAACATGGCCCCACGGTGACAACAGACCTGTGAC AGGAAGCCCAAAGCTCACATAGAAATGGTGGACAGATCAAAGTCTCTATAGTAAGGGAAAAAAAGAGAGGTGGCAGGCATGAGCCCCCTGCACCCAGTGG CTCGTGTCCATACTGAGTCCAGACCCTGATCAAGGCCTGACTTAGTGTCACTGGCAGTCCCACTAAATTACACTTCCTTACACTGGCCCGATGCGACAAA TCAGGTGGCTCCCTTCTGTCACGTGGAGCACACAGTGTTTTCCATCATCCATAGCTTTCTTCCTGATGGTGTTTGCATTATTGCGCCTTCCCAATCTGCA TGCTGCGTTGGGCTTGCGGTGCCTGAACAAGGTTTGCTCCCATGAGCTCAGGCACCCTAGGATCCCCTGTTAGACTATTAGGCTGTCCAGCATGGTCTCC TTTCCCTTCTTGGTGGTGGTCTTTTCCCTTTCCAGAATAGAACAGTGATTCTTAAAATAAGTTAGAGCAGGCCGGGCGCGGTGGCTCATGCCTGTAATCC CAGCACTTTGGGAGGCCGAGGTGGGTGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGGCCAAGATGATGAAACCCCGTCTCTATTAAAAATACAAAAA TTAGCTGGGCGTGGTGGCAGGCACCTGTAATCCCAGCTTCCTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGGGGCAGAGGTTGCAGTGAGCCGA GATCACGCCACTGAACTCCAGCCTGGGCAACAGAGTGAGACTCTGTCTCAAAAAAAAAAAAAAAACAAAAACAAAAAAGCAAGATCATCCACTACACATG AACATGAATCACAGTATTATTTGCACAGGAAGGGTGTAACAAAATATGAATGTATCAAAAAATAGAAATAAAGTCTTTGCAGAAAAAGTCTGTTTTTCTC TGAAGTGTGTTGAGATTATCTGACAACTCTAAGATTGTACTTAAATTGTCAATAAAGCATCAAAA

PARK2.u.f.6 (forward primer)
PARK2.u.r.9 (reverse primer)
Single exon skipping

Frame 0

QVDQSTTAFMCIAKAPVKECSRENSGYSAAPAG RQRSP*PRVHLAGMMF*FQTG*VVNANPHTALGL VQNFSLNVEHTPPLTRKHQ*LCT*SQQIVGTSL ALRAQTSGAPSWFSSATPAT*FA*TVSTYTV*Q DSMIGSLFTTLNLATPCLVWLAVPTP*LKSSITS GFWEKSSTTGTSSMVQRSVSCRWGACYAPALAV ERGCCRSLTRGKSPAKGAMAWAVGLPSAGNVKK RTMKGSAVPYLKPQEQLLRPTESMKEPPSRLVGK QPPKKPSRKPPSPVPAAMYQWKKMEAACT*SVR SPSAGSSGAGTVAASGTASAWGTTGSTCSQGGR APHRHILGEHTQCLPSFSNSLFKHTHTRARAHTH SSSFFQSPTTAKLQKKLLDPFHYVHEKQQSKIT EEAPESLSVCPHKTAEPSATPPTGVLSLRMTQI PEHRFKCNPCICMGHSHLNSRQAESVAGERVLTF NILPFTFSKHHEDAIDKVFLCKMNCSGFSKLDS WL*Q*CSYLNFQKASIPKEPQAIVKNICLSLRI PSI*IALMKYQLCVNQLVTK*EIMKVNLNVECLN YREEIKLMYFHSLS*FATLERNCFSESITKKSI V*F*VFILQLGDFANTFGSTVNLIDKVPIKETR LEMISK*YSILTKVNIIKSESLKRSLSRTTKMKT RPTLSIRRVYTPLAHPLCPICKSQGALHTRGSP GETFS*DSKLTRIFLMLTWIGFQFNQTFSFFFS HSQHNQKINNTACGKPHALTHTTQKRKYNHYLLF YLYCLTSQEDREHN*GHESH*HMEALLDLETVN Y*IGNRASLFRCSTEILAGGKRGDELKFSTSWD TCPSFPNCLR*PISSNHLRTVPSSQRPCTGERLG SAAATSAFTASCGFTV*KSTDSNMAPR*QQTCD RKPKAHIEMVDRSKSL**GKKREVAGMSPLHPV ARVHTESRP*SRPDLVSLAVPLNYTSLHWPDATN QVAPFCHVEHTVFSIIHSFLPDGVCIIAPSQSA CCVGLAVPEQGLLP*AQAP*DPLLDY*AVQHGL LSLLGGGLFPFQNRTVILKIS*SRPGAVAHACNP STLGGRGGWITRSGVQDQPGQDDETPSLLKIQK LAGRGGRHL*SQLPGRLRQENHLNPGGRGCSEP RSRH*TPAWATE*DSVSKKKKKQKQKSKIIHYT* T*ITVLFAQEGCNKI*MYQKIEIKSLQKKSVFL *SVLRLSDNSKIVLKLSIKHQ

Frame 1

R*INLQQLLCVLQRPLSKSAAGKTQGTVQHLQA GNAHLDPGSILLG*CFNSKPDEW*MPIPTLPWD *CRIFL*MWSTPHL*QGNISSFAPDRNK*SEHHL HYVHRRQEPRPGFPVQLPPRDLLRLFPLILCDK TQ*SAVCSRPSTWLLPALCGWLSQLLD*RAPSL QDSGRRAVQPVPAVWCRGVCPADGGRVMPPPWLW SGAAAGA*PEESHLRRGQWPGLWVCLLPGM*RS VP*RGVQCRI*SLRNNYSGLQSR*KSRRAGSLG SSLQRNHQENHQALSPLPCTSGKKWRLHAHEVSA APVQARVVLELWLRVEPRLHGGPLVRRVARAAG RPIATSWGSIPSVYLHFLILFSNTHTHARARTH TLQVFFKVQLQPNCRRNSWIPFTMSMKNSRVKLQ KKLLNPFQFVHTRQQSHLRHHQQAFSASG*HKY QSTDSSAIHVSVWVILT*IRDRQNQ*LEREFSH LISCLLPSVNTMKMPLTRCFSVK*TAVGSPN*IH GFNSNVLI*IFRKHLFPKNPRQ*SKTFVYP*EF HLYKSH**NTNYA*INLSQSEKL*KLI*MLNV* ITGKKSS*CTFIPFHDLQL*KEIVFLKVSPKNL* FDSEYSFCNLEILLIHLAPL*I**IKCL*RKHV *K*FQNDIQS*QK*TLLNQNL*RGAFPELPK*R HARLSPSEGFIPLWHTLSVQSASPRELCIPGVPQ ERPSLRTVNSLEYSLC*HGLDFSSIKLSAFFSA IHNTIKRLTTLHAANRMLLPTLRRRESTTTIFC STCIV*LLRKIVNITEGMSLTSTWRPFWI*RL*I IKSATGLLFLDVALKSLLEGREGMNSSFPHPGT PVPLFLTA*DNPFLPTI*GQSRRLRGPAPGRDW ALQQPHQHSQLHVASLSENLPTPTWPHGDNRPVT GSPKLT*KWWTDQSLYSKGKKERWQA*APCTQW LVSILSPDPDQGLT*CHWQSH*ITLPYTGPMRQ IRWLPSVTWSTQCFPSSIAFFLMVFALLRLPNLH AALGLRCLNKVCSHELRHPRIPC*TIRLSSMVS FPFLVVVFSLSRIEQ*FLK*VRAGRARWLMPVI PALWEAEVGGSRGQEFKTSLAKMMKPRLY*KYKN *LGVVAGTCNPSFLGG*GRRIT*TRGAEVAVSR DHATELQPGQQSETLSQKKKKNKNKKARSSTTH EHESQYYLHRKGVTKYECIKK*K*SLCRKSLFFS EVC*DYLTTLRLYLNCQ*SIK

Frame 2

GRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQ ATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGT SAEFFFKCGAHPTSDKETSVALHLIATNSRNIT CITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTR LNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHF RILGEEQYNRYQQYGAEECVLQMGGVLCPRPGC GAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEA YHEGECSAVFEASGTTTQAYRVDERAAEQARWE AASKETIKKTTKPCPRCHVPVEKNGGCMHMKCP QPQCRLEWCWNCGCEWNRVCMGDHWFDV*PGRPG APSPHPGGAYPVSTFIF*FSFQTHTHTRARAHT LFKFFSKSNYSQIAEETPGSLSLCP*KTAE*NY RRSS*IPFSLSTQDSRAICDTTNRRSQPPDDTNT RAQIQVQSMYLYGSFSPEFETGRISSWRESSHI *YPAFYLQ*TP*RCH*QGVSL*NELQWVLQTRF MALTVMFLFKFSESIYSQRTPGNSQKHLFILKNS IYINRINEIPTMRKSTCHKVRNYES*FEC*MFE LQGRNQVNVLSFPFMICNFRKKLFF*KYHQKIY SLILSIHFATWRFC*YIWLHCKFNR*SAYKGNTF RNDFKMIFNLNKSEHY*IRIFKEEPFQNYQNED TPDSLHQKGLYPFGTPSLSNLQVPGSSAYQGFP RRDLLLGQ*TH*NIPYVDMDWISVQSNFQLFFQP FTTQSKD*QHCMRQTACSYPHYAEEKVQPLSFV LPVLSDFSGRS*T*LRA*VSLAHGGPFGFRDCK LLNRQQGFSF*M*H*NPCWREERG*TQVFHILGH LSLFS*LPKITHFFQPSEDSPVVSEALHRGETG LCSSHISIHSFMWLHCLKIYRLQHGPTVTTDL* QEAQSSHRNGGQIKVSIVREKKRGGRHEPPAPSG SCPY*VQTLIKA*LSVTGSPTKLHFLTLARCDK SGGSLLSRGAHSVFHHP*LSS*WCLHYCAFPIC MLRWACGA*TRFAPMSSGTLGSPVRLLGCPAWSP FPSWWWSFPFPE*NSDS*NKLEQAGRGGSCL*S QHFGRPRWVDHEVRSSRPAWPR**NPVSIKNTK ISWAWWQAPVIPASWEAEAGESLEPGGQRLQ*AE ITPLNSSLGNRVRLCLKKKKKTKTKKQDHPLHM NMNHSIICTGRV*QNMNVSKNRNKVFAEKVCFS LKCVEII*QL*DCT*IVNKASK

Sequence PARK2.aAug05

PARK2.u.f.6 (forward primer)
PARK2.u.r.9 (reverse primer)
Single exon skipping

Frame 0

SVCQVQLQPWFPSGGRF*HQHLPAQGGGC*ATG GSG*PVACDFRREGAEE*LDCAEL*PGSAEHCSH CAETVEKRSRNECNWRRRPQKRGGRL*AGAPEL DSGGPQQLSPPRRLCGAGCHSAH*QQEGLTTSW KSSR*INLQQLLCVLQRPLSKSAAGKTQGTVQHL QAGNAHLDPGSILLG*CFNSKPDEW*MPIPTLP WD*CRIFL*MWSTPHL*QGNISSFAPDRNK*SE HHLHYVHRRQEPRPGFPVQLPPRDLLRLFPLILC DKTQ*SAVCSRPSTWLLPALCGNWRHSGA*RSS GGIQERSRWLSQLLD*RAPSLQDSGRRAVQPVP AVWCRGVCPADGGRVMPPPWLWSGAAAGA*PEES HLRRGQWPGLWVWTTKNKISCLREK*VPHSIHR SRKSHW*QSYRRITEFQMWKKP*TSLTPVIIRM WFTDLL*DACEFTRA*FFFPSIIKIEKVQLLPCG YARNVSCYKKNRV*KS*KPN

Frame 1

VFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQG VPADQLRVIFAGKELRNDWTVQNCDLDQQSIVH IVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSL TRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAG SPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCST CRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCP GTSAEFFFKCGAHPTSDKETSVALHLIATNSRN ITCITCTDVRSPVLVFQCNSRHVICLDCFHLYC VTRLNDRQFVHDPQLGYSLPCVGTGDTVVLRGAL GGFRRGVAGCPNSLIKELHHFRILGEEQYNRYQ QYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRK VTCEGGNGLGCGYGQRRTK*AASGRSECLIQYIV QGKVIGSKAIEELQSSRCGKSPRRH*LQ*LSGC GSQIYCKMPVNSPVLNFFFPQLSR*KKYNSYHV GMQEMLAVTKKIAYKKVENQ

Frame 2

CLSGSTPAMVSQWRSILTPASSSSRRWLLSDRG FRLTSCV*FSQGRS*GMTGLCRIVTWISRALFT LCRDRGEKVKK*MQLEATTPETRREAVSGSPRA *LGWTSAAQSSQETLWGWLSFCTLTAGRTHHQLE VQQVDQSTTAFMCIAKAPVKECSRENSGYSAAP AGRQRSP*PRVHLAGMMF*FQTG*VVNANPHTA LGLVQNFSLNVEHTPPLTRKHQ*LCT*SQQIVGT SLALRAQTSGAPSWFSSATPAT*FA*TVSTYTV *QDSMIGSLFTTLNLATPCLVWELETQWCLEEL WGDSGEESLAVPTP*LKSSITSGFWEKSSTTGTS SMVQRSVSCRWGACYAPALAVERGCCRSLTRGK SPAKGAMAWAVGMDNEEQNKLPQGEVSASFNTS FKEKSLVAKL*KNYRVPDVEKALDVINSSDYQDV VHRFIVRCL*IHPCLIFFSLNYQDRKSTTLTMW VCKKC*LLQKKSRIKKLKTK