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Sequences

Sequence CASP10.gAug05

AAGGAAATGGAGATCCAAAGGAAAGCCTGAAGCACTTTGTGGCTTCCACGGGTTCGTTTCTAGGAAGCTTTTGCTTTACCTGGGGAAACCCCAAGCTCTA CAGTGAGAAAGTTGTAAATTAGCCTTTAGGAGACGCTGTTTGTCAAAGTTATCTTAACCCTGGAAAAGGGGAGGGAAAAAGGCAGATAAGCAGTGATGAC ATCAGCAGGAAACTAGTATCAGGCTACCCAGTCCTGAAGATTCAGTTTTCACTTAAACAACCAGCAAGTCTTGAAGTCTCTTCCCAAGCAAATGGGAGCT TCTTTGGACCTTGGAGCACACAGAGGATTCTACTTTCTTTAAAACTTTGTTTTCAGGCAATTTCCCTGAGAACCGTTTACTTCCAGAAGATTGGTGGAGC TTGATCTGAAGGCTGGCCATGAAATCTCAAGGTCAACATTGGTATTCCAGTTCAGATAAAAACTGTAAAGTGAGCTTTCGTGAGAAGCTTCTGATTATTG ATTCAAACCTGGGGGTCCAAGATGTGGAGAACCTCAAGTTTCTCTGCATAGGATTGGTCCCCAACAAGAAGCTGGAGAAGTCCAGCTCAGCCTCAGATGT TTTTGAACATCTCTTGGCAGAGGATCTGCTGAGTGAGGAAGACCCTTTCTTCCTGGCAGAACTCCTCTATATCATACGGCAGAAGAAGCTGCTGCAGCAC CTCAACTGTACCAAAGAGGAAGTGGAGCGACTGCTGCCCACCCGACAAAGGGTTTCTCTGTTTAGAAACCTGCTCTACGAACTGTCAGAAGGCATTGACT CAGAGAACTTAAAGGACATGATCTTCCTTCTGAAAGACTCGCTTCCCAAAACTGAAATGACCTCCCTAAGTTTCCTGGCATTTCTAGAGAAACAAGGTAA AATAGATGAAGATAATCTGACATGCCTGGAGGACCTCTGCAAAACAGTTGTACCTAAACTTTTGAGAAACATAGAGAAATACAAAAGAGAGAAAGCTATC CAGATAGTGACACCTCCTGTAGACAAGGAAGCCGAGTCGTATCAAGGAGAGGAAGAACTAGTTTCCCAAACAGATGTTAAGACATTCTTGGAAGCCTTAC CGCAGGAGTCCTGGCAAAATAAGCATGCAGGTAGTAATGAGGGCAGCTGTGTACAGGATGAATCGGAACCACAGAGGCCTCTGTGTCATTGTCAACAACC ACAGCTTTACCTCCCTGAAGGACAGACAAGGAACCCATAAAGATGCTGAGATCCTGAGTCATGTGTTCCAGTGGCTTGGGTTCACAGTGCATATACACAA TAATGTGACGAAAGTGGAAATGGAGATGGTCCTGCAGAAGCAGAAGTGCAATCCAGCCCATGCCGACGGGGACTGCTTCGTGTTCTGTATTCTGACCCAT GGGAGATTTGGAGCTGTCTACTCTTCGGATGAGGCCCTCATTCCCATTCGGGAGATCATGTCTCACTTCACAGCCCTGCAGTGCCCTAGACTGGCTGAAA AACCTAAACTCTTTTTCATCCAGGCCTGCCAAGGTGAAGAGATACAGCCTTCCGTATCCATCGAAGCAGATGCTCTGAACCCTGAGCAGGCACCCACTTC CCTGCAGGACAGTATTCCTGCCGAGGCTGACTTCCTACTTGGTCTGGCCACTGTCCCAGGCTATGTATCCTTTCGGCATGTGGAGGAAGGCAGCTGGTAT ATTCAGTCTCTGTGTAATCATCTGAAGAAATTGGTCCCAAGACATGAAGACATCTTATCCATCCTCACTGCTGTCAACGATGATGTGAGTCGAAGAGTGG ACAAACAGGGAACAAAGAAACAGATGCCCCAGCCTGCTTTCACACTAAGGAAAAAACTAGTATTCCCTGTGCCCCTGGATGCACTTTCATTATAGCAGAG AGTTTTTGTTGGTTCTTAGACCTCAAACGAATCATTGGCTATAACCTCCAGCCTCCTGCCCAGCACAGGAATCGGTGGTCTCCACCTGTCATTCTAGAAA CAGGAAACACCGTGTTTTCTGACACAGTCAATTCTGATTTTCTTTTTCTTTTGCAAGTCTAAATGTTAGAAAACTTTCTTTTTTTTGGAGATAGTCTCAT TCTGTCACCCAGACTGGAGTGCAGGGGGGCAATCACGGCTCACTGTAGTCTCGACCTCCCAGGTTCAAGCGATCCTCCCACCTCAGCCTCCCAAGTAGCT GAGACTACAGGTGTGTGTCCATGCACAGCTAACTTTTTATTTTTTTTGTGGAGATGGGGTTTCACTATGTTGCCTAAGCTGGTCTCAAACTCCTGGGCTC AAGCGATCCTCCCACCTCAGCTTCTCAAAGTTCTGGGACTACAGGCATGAAATACTGTGCCTGGCCTGGGGACCAGGTGCATTTTAAGGTTCCTTGGTGT TCAAAAACCACGTTCTTAGCCTAGATTGAGCTTAGATTGCCTCTCTAGACAACTACCCCTTAGTTATAATTCTGTGTCCCCTCTGCATGCCCTTAAACAT TGGACAGTGAGGTCACAGTCCACCCACCCTCTCTCTGATCTCCCCCTTCCTAAGACTTCTCTTTTGCACATCTAGTGAGGTGAAAATTTGGTCTATGCCA GGCCCATTTCCTGCTTTTGTGTAAGGAAGGTGCTCACATAGGAAGTTTTTATTTGGTTAGAGACAGGTTTCCCTGTAGGAAGATGATGGCTCATTTACAC TCAGCTGCTCTGCAAGCAGAAACTTTACAACCTGATGTCATATTCCATTTTGGACTGGGTGCGGTGACTCATGCCTGTAATCCCAGTACTCTGGGAAGCC AAGGCAGGCAGATCACTTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAATACGGCAAAACCTCATCATTACTAAAAACACAAAAATTAGCCAGGTGTGGC GGCGAGCACCTGTAATCCCAGCTACTCGGGAGGCTGAGACAGGAGAATCTCTTGAATCCAGGAGGCAGAGGCTGTGGTGAGCCAAGATGACACAACTGCA CTCCAGCTTGGGCAACAGGGCGAGACCTTGTTTAAAAAAAAAATTCAATATTGGGGTTGGAACATTTCAGTTGCCATTGACAGAACACCCAATTCAAATT GACTGAAGCAAAGAAGGGAATTTATTGCCTCTTTCACATTGAAACCCAGGAGTGGATAACACTGGCTTCAGGCAAAGCTTGAATCAGGACTCAATCTACA GGCCAGCACCTTTCTCTTGGCCGGATGTCCTCAGGGCTGGCAGATGCAGTAGACTGCAGTGGACAGTCCCCACCTTGTTACTGCTACTACACTTTGCTCC TCTGGCCCAAGGCATGAGGAGAGAGGCTGTGTCAGAAACTGAAGCTGTTCTCAGGATCACTGGGCTCTTCTTGGCAGAGGGGATGTCTGGCTTGCCTGAA GGGAGTGGCTCTGTAAGGACGCCTTGATGCTTTCTTCATTAAGATTTTGAGCATTTTTACGTACTTGAGCTTTTTTTTTTTTTTTTTTCAATTTCTAGAG GAACTTTTTCTCTGTTAATTCCTGGAACTGTATTTTGAATCCTTAAAGGTGAGCCCTCATAGGGAGATCCAAAGTCCTGTGGTTAACGCCTTCATTTATA GATGAGGCAGCTGAGGCCTGGGGATGTGAACAACCTGCTCACAGTCCTCATTTACTGGATTTGACTTCAGCCAGGTGAACTGGAATGCCTTGGGGCGTGG AAGGGCATTAGGAGTGTTTCATTTGATATGTGAATGCTCATAAAAAAATGTCAAGGAATGAAGAACAACAACTCTCAGTGGTGCCTGCATTTATAATTAT TTATGTGAAAGTCAAATTCATGTACAGTAAATTTGTTATAAGAATATTCACAAGAACACTGTTCTGATATCTCTGATTGTCATGTGGATTTGAATGTAGC TTGACAGAGGGAATGTCTAATCTATATTGACAGGGCAGGAACACCGTCATCTTAGACAAACACCGCCACTTTAAGTTCCAGTTCCCTTTCTAG

CASP10.b.f.23 (forward primer)
CASP10.u.r.15 (reverse primer)
Single exon skipping

Frame 0

KEMEIQRKA*STLWLPRVRF*EAFALPGETPSS TVRKL*ISL*ETLFVKVILTLEKGREKGR*AVMT SAGN*YQATQS*RFSFHLNNQQVLKSLPKQMGA SLDLGAHRGFYFL*NFVFRQFP*EPFTSRRLVE LDLKAGHEISRSTLVFQFR*KL*SELS*EASDY* FKPGGPRCGEPQVSLHRIGPQQEAGEVQLSLRC F*TSLGRGSAE*GRPFLPGRTPLYHTAEEAAAA PQLYQRGSGATAAHPTKGFSV*KPALRTVRRH*L RELKGHDLPSERLASQN*NDLPKFPGISRETR* NR*R*SDMPGGPLQNSCT*TFEKHREIQKRESY PDSDTSCRQGSRVVSRRGRTSFPNRC*DILGSLT AGVLAK*ACR***GQLCTG*IGTTEASVSLSTT TALPP*RTDKEPIKMLRS*VMCSSGLGSQCIYT IM*RKWKWRWSCRSRSAIQPMPTGTASCSVF*PM GDLELSTLRMRPSFPFGRSCLTSQPCSALDWLK NLNSFSSRPAKVKRYSLPYPSKQML*TLSRHPL PCRTVFLPRLTSYLVWPLSQAMYPFGMWRKAAGI FSLCVII*RNWSQDMKTSYPSSLLSTMM*VEEW TNREQRNRCPSLLSH*GKN*YSLCPWMHFHYSR EFLLVLRPQTNHWL*PPASCPAQESVVSTCHSRN RKHRVF*HSQF*FSFSFASLNVRKLSFFWR*SH SVTQTGVQGGNHGSL*SRPPRFKRSSHLSLPSS *DYRCVSMHS*LFIFFVEMGFHYVA*AGLKLLGS SDPPTSASQSSGTTGMKYCAWPGDQVHFKVPWC SKTTFLA*IELRLPL*TTTP*L*FCVPSACP*T LDSEVTVHPPSL*SPPS*DFSFAHLVR*KFGLCQ AHFLLLCKEGAHIGSFYLVRDRFPCRKMMAHLH SAALQAETLQPDVIFHFGLGAVTHACNPSTLGS QGRQIT*GQEFETSLANTAKPHHY*KHKN*PGVA ASTCNPSYSGG*DRRIS*IQEAEAVVSQDDTTA LQLGQQGETLFKKKIQYWGWNISVAIDRTPNSN *LKQRREFIASFTLKPRSG*HWLQAKLESGLNLQ ASTFLLAGCPQGWQMQ*TAVDSPHLVTATTLCS SGPRHEERGCVRN*SCSQDHWALLGRGDVWLA* REWLCKDALMLSSLRF*AFLRT*AFFFFFFNF*R NFFSVNSWNCILNP*R*ALIGRSKVLWLTPSFI DEAAEAWGCEQPAHSPHLLDLTSAR*TGMPWGV EGH*ECFI*YVNAHKKMSRNEEQQLSVVPAFIII YVKVKFMYSKFVIRIFTRTLF*YL*LSCGFECS LTEGMSNLY*QGRNTVILDKHRHFKFQFPF*

Frame 1

RKWRSKGKPEALCGFHGFVSRKLLLYLGKPQAL Q*ESCKLAFRRRCLSKLS*PWKRGGKKADKQ** HQQETSIRLPSPEDSVFT*TTSKS*SLFPSKWEL LWTLEHTEDSTFFKTLFSGNFPENRLLPEDWWS LI*RLAMKSQGQHWYSSSDKNCKVSFREKLLII DSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDV FEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQH LNCTKEEVERLLPTRQRVSLFRNLLYELSEGID SENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGK IDEDNLTCLEDLCKTVVPKLLRNIEKYKREKAI QIVTPPVDKEAESYQGEEELVSQTDVKTFLEAL PQESWQNKHAGSNEGSCVQDESEPQRPLCHCQQP QLYLPEGQTRNP*RC*DPESCVPVAWVHSAYTQ *CDESGNGDGPAEAEVQSSPCRRGLLRVLYSDP WEIWSCLLFG*GPHSHSGDHVSLHSPAVP*TG*K T*TLFHPGLPR*RDTAFRIHRSRCSEP*AGTHF PAGQYSCRG*LPTWSGHCPRLCILSACGGRQLV YSVSV*SSEEIGPKT*RHLIHPHCCQR*CESKSG QTGNKETDAPACFHTKEKTSIPCAPGCTFIIAE SFCWFLDLKRIIGYNLQPPAQHRNRWSPPVILE TGNTVFSDTVNSDFLFLLQV*MLENFLFFGDSLI LSPRLECRGAITAHCSLDLPGSSDPPTSASQVA ETTGVCPCTANFLFFLWRWGFTMLPKLVSNSWA QAILPPQLLKVLGLQA*NTVPGLGTRCILRFLGV QKPRS*PRLSLDCLSRQLPLSYNSVSPLHALKH WTVRSQSTHPLSDLPLPKTSLLHI**GENLVYA RPISCFCVRKVLT*EVFIWLETGFPVGR*WLIYT QLLCKQKLYNLMSYSILDWVR*LMPVIPVLWEA KAGRSLEVRSSRPAWPIRQNLIITKNTKISQVW RRAPVIPATREAETGESLESRRQRLW*AKMTQLH SSLGNRARPCLKKKFNIGVGTFQLPLTEHPIQI D*SKEGNLLPLSH*NPGVDNTGFRQSLNQDSIY RPAPFSWPDVLRAGRCSRLQWTVPTLLLLLHFAP LAQGMRREAVSETEAVLRITGLFLAEGMSGLPE GSGSVRTP*CFLH*DFEHFYVLELFFFFFSISR GTFSLLIPGTVF*ILKGEPS*GDPKSCG*RLHL* MRQLRPGDVNNLLTVLIYWI*LQPGELECLGAW KGIRSVSFDM*MLIKKCQGMKNNNSQWCLHL*L FM*KSNSCTVNLL*EYSQEHCSDISDCHVDLNVA *QRECLIYIDRAGTPSS*TNTATLSSSSLS

Frame 2

GNGDPKESLKHFVASTGSFLGSFCFTWGNPKLY SEKVVN*PLGDAVCQSYLNPGKGEGKRQISSDD ISRKLVSGYPVLKIQFSLKQPASLEVSSQANGS FFGPWSTQRILLSLKLCFQAISLRTVYFQKIGGA *SEGWP*NLKVNIGIPVQIKTVK*AFVRSF*LL IQTWGSKMWRTSSFSA*DWSPTRSWRSPAQPQM FLNISWQRIC*VRKTLSSWQNSSISYGRRSCCST STVPKRKWSDCCPPDKGFLCLETCSTNCQKALT QRT*RT*SSF*KTRFPKLK*PP*VSWHF*RNKV K*MKII*HAWRTSAKQLYLNF*ET*RNTKERKLS R**HLL*TRKPSRIKERKN*FPKQMLRHSWKPY RRSPGKISMQVVMRAAVYRMNRNHRGLCVIVNN HSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHN NVTKVEMEMVLQKQKCNPAHADGDCFVFCILTH GRFGAVYSSDEALIPIREIMSHFTALQCPRLAE KPKLFFIQACQGEEIQPSVSIEADALNPEQAPTS LQDSIPAEADFLLGLATVPGYVSFRHVEEGSWY IQSLCNHLKKLVPRHEDILSILTAVNDDVSRRV DKQGTKKQMPQPAFTLRKKLVFPVPLDALSL*QR VFVGS*TSNESLAITSSLLPSTGIGGLHLSF*K QETPCFLTQSILIFFFFCKSKC*KTFFFLEIVS FCHPDWSAGGQSRLTVVSTSQVQAILPPQPPK*L RLQVCVHAQLTFYFFCGDGVSLCCLSWSQTPGL KRSSHLSFSKFWDYRHEILCLAWGPGAF*GSLV FKNHVLSLD*A*IASLDNYPLVIILCPLCMPLNI GQ*GHSPPTLSLISPFLRLLFCTSSEVKIWSMP GPFPAFV*GRCSHRKFLFG*RQVSL*EDDGSFT LSCSASRNFTT*CHIPFWTGCGDSCL*SQYSGKP RQADHLRSGVRDQPGQYGKTSSLLKTQKLARCG GEHL*SQLLGRLRQENLLNPGGRGCGEPR*HNC TPAWATGRDLV*KKNSILGLEHFSCH*QNTQFKL TEAKKGIYCLFHIETQEWITLASGKA*IRTQST GQHLSLGRMSSGLADAVDCSGQSPPCYCYYTLL LWPKA*GERLCQKLKLFSGSLGSSWQRGCLACLK GVAL*GRLDAFFIKILSIFTYLSFFFFFFQFLE ELFLC*FLELYFESLKVSPHREIQSPVVNAFIY R*GS*GLGM*TTCSQSSFTGFDFSQVNWNALGRG RALGVFHLICECS*KNVKE*RTTTLSGACIYNY LCESQIHVQ*ICYKNIHKNTVLISLIVMWI*M* LDRGNV*SILTGQEHRHLRQTPPL*VPVPFL

Sequence CASP10.cAug05

CASP10.b.f.23 (forward primer)
CASP10.u.r.15 (reverse primer)
Single exon skipping

Frame 0

Frame 1

Frame 2

Sequence CASP10.bAug05

AAGGAAATGGAGATCCAAAGGAAAGCCTGAAGCACTTTGTGGCTTCCACGGGTTCGTTTCTAGGAAGCTTTTGCTTTACCTGGGGAAACCCCAAGCTCTA CAGTGAGAAAGTTGTAAATTAGCCTTTAGGAGACGCTGTTTGTCAAAGTTATCTTAACCCTGGAAAAGGGGAGGGAAAAAGGCAGATAAGCAGTGATGAC ATCAGCAGGAAACTAGTATCAGGCTACCCAGTCCTGAAGATTCAGTTTTCACTTAAACAACCAGCAAGTCTTGAAGTCTCTTCCCAAGCAAATGGGAGCT TCTTTGGACCTTGGAGCACACAGAGGATTCTACTTTCTTTAAAACTTTGTTTTCAGGCAATTTCCCTGAGAACCGTTTACTTCCAGAAGATTGGTGGAGC TTGATCTGAAGGCTGGCCATGAAATCTCAAGGTCAACATTGGTATTCCAGTTCAGATAAAAACTGTAAAGTGAGCTTTCGTGAGAAGCTTCTGATTATTG ATTCAAACCTGGGGGTCCAAGATGTGGAGAACCTCAAGTTTCTCTGCATAGGATTGGTCCCCAACAAGAAGCTGGAGAAGTCCAGCTCAGCCTCAGATGT TTTTGAACATCTCTTGGCAGAGGATCTGCTGAGTGAGGAAGACCCTTTCTTCCTGGCAGAACTCCTCTATATCATACGGCAGAAGAAGCTGCTGCAGCAC CTCAACTGTACCAAAGAGGAAGTGGAGCGACTGCTGCCCACCCGACAAAGGGTTTCTCTGTTTAGAAACCTGCTCTACGAACTGTCAGAAGGCATTGACT CAGAGAACTTAAAGGACATGATCTTCCTTCTGAAAGACTCGCTTCCCAAAACTGAAATGACCTCCCTAAGTTTCCTGGCATTTCTAGAGAAACAAGGTAA AATAGATGAAGATAATCTGACATGCCTGGAGGACCTCTGCAAAACAGTTGTACCTAAACTTTTGAGAAACATAGAGAAATACAAAAGAGAGAAAGCTATC CAGATAGTGACACCTCCTGTAGACAAGGAAGCCGAGTCGTATCAAGGAGAGGAAGAACTAGTTTCCCAAACAGATGTTAAGACATTCTTGGAAGCCTTAC CGCAGGAGTCCTGGCAAAATAAGCATGCAGGTAGTAATGGTAACAGAGCCACAAATGGTGCACCAAGCCTGGTCTCCAGGGGGATGCAAGGAGCATCTGC TAACACTCTAAACTCTGAAACCAGCACAAAGAGGGCAGCTGTGTACAGGATGAATCGGAACCACAGAGGCCTCTGTGTCATTGTCAACAACCACAGCTTT ACCTCCCTGAAGGACAGACAAGGAACCCATAAAGATGCTGAGATCCTGAGTCATGTGTTCCAGTGGCTTGGGTTCACAGTGCATATACACAATAATGTGA CGAAAGTGGAAATGGAGATGGTCCTGCAGAAGCAGAAGTGCAATCCAGCCCATGCCGACGGGGACTGCTTCGTGTTCTGTATTCTGACCCATGGGAGATT TGGAGCTGTCTACTCTTCGGATGAGGCCCTCATTCCCATTCGGGAGATCATGTCTCACTTCACAGCCCTGCAGTGCCCTAGACTGGCTGAAAAACCTAAA CTCTTTTTCATCCAGGCCTGCCAAGGTGAAGAGATACAGCCTTCCGTATCCATCGAAGCAGATGCTCTGAACCCTGAGCAGGCACCCACTTCCCTGCAGG ACAGTATTCCTGCCGAGGCTGACTTCCTACTTGGTCTGGCCACTGTCCCAGGCTATGTATCCTTTCGGCATGTGGAGGAAGGCAGCTGGTATATTCAGTC TCTGTGTAATCATCTGAAGAAATTGGTCCCAAGACATGAAGACATCTTATCCATCCTCACTGCTGTCAACGATGATGTGAGTCGAAGAGTGGACAAACAG GGAACAAAGAAACAGATGCCCCAGCCTGCTTTCACACTAAGGAAAAAACTAGTATTCCCTGTGCCCCTGGATGCACTTTCATTATAGCAGAGAGTTTTTG TTGGTTCTTAGACCTCAAACGAATCATTGGCTATAACCTCCAGCCTCCTGCCCAGCACAGGAATCGGTGGTCTCCACCTGTCATTCTAGAAACAGGAAAC ACCGTGTTTTCTGACACAGTCAATTCTGATTTTCTTTTTCTTTTGCAAGTCTAAATGTTAGAAAACTTTCTTTTTTTTGGAGATAGTCTCATTCTGTCAC CCAGACTGGAGTGCAGGGGGGCAATCACGGCTCACTGTAGTCTCGACCTCCCAGGCTCAAGCTGTCCTCCCGCCTCAGCTTCCCAAGTAGCTGGGACCAC AGGTGTGTACCACCGTGCCCGGATTTTTTTTATTCTTTATTTTTTGTAGAGATGGAGGGATCTCACTTTGTTGCACAGGCTGGTTTCAAACTCCTAGGCC CAAGTGATCCTCCCACCTCTGTCCCCAAAATACTGGGATTATAGGCACGAGCCACCACACCTGGCCAGAAAACTTTCATTATTGAAGACTTGGATTGTAG CCTTGGTTTTGGATGTCTATTCTGAAGACAGAGTAATTGGCTTTGGTTTGTGCAGGTACTTTTTCTTTGAGACAGAGTCACTCCGTCACCTGGGCTGGAG TGCAGTGGTGGGATCACTGTTCACTGCAGCCTTGACCTCCCAGGTTCAAGCGATCCTCCCACCTCAGCCTCCCAAGTAGCTGAGACTACAGGTGTGTGTC CATGCACAGCTAACTTTTTATTTTTTTTGTGGAGATGGGGTTTCACTATGTTGCCTAAGCTGGTCTCAAACTCCTGGGCTCAAGCGATCCTCCCACCTCA GCTTCTCAAAGTTCTGGGACTACAGGCATGAAATACTGTGCCTGGCCTGGGGACCAGGTGCATTTTAAGGTTCCTTGGTGTTCAAAAACCACGTTCTTAG CCTAGATTGAGCTTAGATTGCCTCTCTAGACAACTACCCCTTAGTTATAATTCTGTGTCCCCTCTGCATGCCCTTAAACATTGGACAGTGAGGTCACAGT CCACCCACCCTCTCTCTGATCTCCCCCTTCCTAAGACTTCTCTTTTGCACATCTAGTGAGGTGAAAATTTGGTCTATGCCAGGCCCATTTCCTGCTTTTG TGTAAGGAAGGTGCTCACATAGGAAGTTTTTATTTGGTTAGAGACAGGTTTCCCTGTAGGAAGATGATGGCTCATTTACACTCAGCTGCTCTGCAAGCAG AAACTTTACAACCTGATGTCATATTCCATTTTGGACTGGGTGCGGTGACTCATGCCTGTAATCCCAGTACTCTGGGAAGCCAAGGCAGGCAGATCACTTG AGGTCAGGAGTTCGAGACCAGCCTGGCCAATACGGCAAAACCTCATCATTACTAAAAACACAAAAATTAGCCAGGTGTGGCGGCGAGCACCTGTAATCCC AGCTACTCGGGAGGCTGAGACAGGAGAATCTCTTGAATCCAGGAGGCAGAGGCTGTGGTGAGCCAAGATGACACAACTGCACTCCAGCTTGGGCAACAGG GCGAGACCTTGTTTAAAAAAAAAATTCAATATTGGGGTTGGAACATTTCAGTTGCCATTGACAGAACACCCAATTCAAATTGACTGAAGCAAAGAAGGGA ATTTATTGCCTCTTTCACATTGAAACCCAGGAGTGGATAACACTGGCTTCAGGCAAAGCTTGAATCAGGACTCAATCTACAGGCCAGCACCTTTCTCTTG GCCGGATGTCCTCAGGGCTGGCAGATGCAGTAGACTGCAGTGGACAGTCCCCACCTTGTTACTGCTACTACACTTTGCTCCTCTGGCCCAAGGCATGAGG AGAGAGGCTGTGTCAGAAACTGAAGCTGTTCTCAGGATCACTGGGCTCTTCTTGGCAGAGGGGATGTCTGGCTTGCCTGAAGGGAGTGGCTCTGTAAGGA CGCCTTGATGCTTTCTTCATTAAGATTTTGAGCATTTTTACGTACTTGAGCTTTTTTTTTTTTTTTTTTCAATTTCTAGAGGAACTTTTTCTCTGTTAAT TCCTGGAACTGTATTTTGAATCCTTAAAGGTGAGCCCTCATAGGGAGATCCAAAGTCCTGTGGTTAACGCCTTCATTTATAGATGAGGCAGCTGAGGCCT GGGGATGTGAACAACCTGCTCACAGTCCTCATTTACTGGATTTGACTTCAGCCAGGTGAACTGGAATGCCTTGGGGCGTGGAAGGGCATTAGGAGTGTTT CATTTGATATGTGAATGCTCATAAAAAAATGTCAAGGAATGAAGAACAACAACTCTCAGTGGTGCCTGCATTTATAATTATTTATGTGAAAGTCAAATTC ATGTACAGTAAATTTGTTATAAGAATATTCACAAGAACACTGTTCTGATATCTCTGATTGTCATGTGGATTTGAATGTAGCTTGACAGAGGGAATGTCTA ATCTATATTGACAGGGCAGGAACACCGTCATCTTAGACAAACACCGCCACTTTAAGTTCCAGTTCCCTTTCTAG

CASP10.b.f.23 (forward primer)
CASP10.u.r.15 (reverse primer)
Single exon skipping

Frame 0

KEMEIQRKA*STLWLPRVRF*EAFALPGETPSS TVRKL*ISL*ETLFVKVILTLEKGREKGR*AVMT SAGN*YQATQS*RFSFHLNNQQVLKSLPKQMGA SLDLGAHRGFYFL*NFVFRQFP*EPFTSRRLVE LDLKAGHEISRSTLVFQFR*KL*SELS*EASDY* FKPGGPRCGEPQVSLHRIGPQQEAGEVQLSLRC F*TSLGRGSAE*GRPFLPGRTPLYHTAEEAAAA PQLYQRGSGATAAHPTKGFSV*KPALRTVRRH*L RELKGHDLPSERLASQN*NDLPKFPGISRETR* NR*R*SDMPGGPLQNSCT*TFEKHREIQKRESY PDSDTSCRQGSRVVSRRGRTSFPNRC*DILGSLT AGVLAK*ACR**W*QSHKWCTKPGLQGDARSIC *HSKL*NQHKEGSCVQDESEPQRPLCHCQQPQL YLPEGQTRNP*RC*DPESCVPVAWVHSAYTQ*CD ESGNGDGPAEAEVQSSPCRRGLLRVLYSDPWEI WSCLLFG*GPHSHSGDHVSLHSPAVP*TG*KT* TLFHPGLPR*RDTAFRIHRSRCSEP*AGTHFPAG QYSCRG*LPTWSGHCPRLCILSACGGRQLVYSV SV*SSEEIGPKT*RHLIHPHCCQR*CESKSGQT GNKETDAPACFHTKEKTSIPCAPGCTFIIAESFC WFLDLKRIIGYNLQPPAQHRNRWSPPVILETGN TVFSDTVNSDFLFLLQV*MLENFLFFGDSLILS PRLECRGAITAHCSLDLPGSSCPPASASQVAGTT GVYHRARIFFILYFL*RWRDLTLLHRLVSNS*A QVILPPLSPKYWDYRHEPPHLARKLSLLKTWIV ALVLDVYSEDRVIGFGLCRYFFFETESLRHLGWS AVVGSLFTAALTSQVQAILPPQPPK*LRLQVCV HAQLTFYFFCGDGVSLCCLSWSQTPGLKRSSHL SFSKFWDYRHEILCLAWGPGAF*GSLVFKNHVLS LD*A*IASLDNYPLVIILCPLCMPLNIGQ*GHS PPTLSLISPFLRLLFCTSSEVKIWSMPGPFPAF V*GRCSHRKFLFG*RQVSL*EDDGSFTLSCSASR NFTT*CHIPFWTGCGDSCL*SQYSGKPRQADHL RSGVRDQPGQYGKTSSLLKTQKLARCGGEHL*S QLLGRLRQENLLNPGGRGCGEPR*HNCTPAWATG RDLV*KKNSILGLEHFSCH*QNTQFKLTEAKKG IYCLFHIETQEWITLASGKA*IRTQSTGQHLSL GRMSSGLADAVDCSGQSPPCYCYYTLLLWPKA*G ERLCQKLKLFSGSLGSSWQRGCLACLKGVAL*G RLDAFFIKILSIFTYLSFFFFFFQFLEELFLC* FLELYFESLKVSPHREIQSPVVNAFIYR*GS*GL GM*TTCSQSSFTGFDFSQVNWNALGRGRALGVF HLICECS*KNVKE*RTTTLSGACIYNYLCESQI HVQ*ICYKNIHKNTVLISLIVMWI*M*LDRGNV* SILTGQEHRHLRQTPPL*VPVPFL

Frame 1

RKWRSKGKPEALCGFHGFVSRKLLLYLGKPQAL Q*ESCKLAFRRRCLSKLS*PWKRGGKKADKQ** HQQETSIRLPSPEDSVFT*TTSKS*SLFPSKWEL LWTLEHTEDSTFFKTLFSGNFPENRLLPEDWWS LI*RLAMKSQGQHWYSSSDKNCKVSFREKLLII DSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDV FEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQH LNCTKEEVERLLPTRQRVSLFRNLLYELSEGID SENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGK IDEDNLTCLEDLCKTVVPKLLRNIEKYKREKAI QIVTPPVDKEAESYQGEEELVSQTDVKTFLEAL PQESWQNKHAGSNGNRATNGAPSLVSRGMQGASA NTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSF TSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNV TKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRF GAVYSSDEALIPIREIMSHFTALQCPRLAEKPK LFFIQACQGEEIQPSVSIEADALNPEQAPTSLQ DSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQS LCNHLKKLVPRHEDILSILTAVNDDVSRRVDKQ GTKKQMPQPAFTLRKKLVFPVPLDALSL*QRVF VGS*TSNESLAITSSLLPSTGIGGLHLSF*KQET PCFLTQSILIFFFFCKSKC*KTFFFLEIVSFCH PDWSAGGQSRLTVVSTSQAQAVLPPQLPK*LGP QVCTTVPGFFLFFIFCRDGGISLCCTGWFQTPRP K*SSHLCPQNTGIIGTSHHTWPENFHY*RLGL* PWFWMSILKTE*LALVCAGTFSLRQSHSVTWAG VQWWDHCSLQP*PPRFKRSSHLSLPSS*DYRCVS MHS*LFIFFVEMGFHYVA*AGLKLLGSSDPPTS ASQSSGTTGMKYCAWPGDQVHFKVPWCSKTTFL A*IELRLPL*TTTP*L*FCVPSACP*TLDSEVTV HPPSL*SPPS*DFSFAHLVR*KFGLCQAHFLLL CKEGAHIGSFYLVRDRFPCRKMMAHLHSAALQA ETLQPDVIFHFGLGAVTHACNPSTLGSQGRQIT* GQEFETSLANTAKPHHY*KHKN*PGVAASTCNP SYSGG*DRRIS*IQEAEAVVSQDDTTALQLGQQ GETLFKKKIQYWGWNISVAIDRTPNSN*LKQRRE FIASFTLKPRSG*HWLQAKLESGLNLQASTFLL AGCPQGWQMQ*TAVDSPHLVTATTLCSSGPRHE ERGCVRN*SCSQDHWALLGRGDVWLA*REWLCKD ALMLSSLRF*AFLRT*AFFFFFFNF*RNFFSVN SWNCILNP*R*ALIGRSKVLWLTPSFIDEAAEA WGCEQPAHSPHLLDLTSAR*TGMPWGVEGH*ECF I*YVNAHKKMSRNEEQQLSVVPAFIIIYVKVKF MYSKFVIRIFTRTLF*YL*LSCGFECSLTEGMS NLY*QGRNTVILDKHRHFKFQFPF*

Frame 2

GNGDPKESLKHFVASTGSFLGSFCFTWGNPKLY SEKVVN*PLGDAVCQSYLNPGKGEGKRQISSDD ISRKLVSGYPVLKIQFSLKQPASLEVSSQANGS FFGPWSTQRILLSLKLCFQAISLRTVYFQKIGGA *SEGWP*NLKVNIGIPVQIKTVK*AFVRSF*LL IQTWGSKMWRTSSFSA*DWSPTRSWRSPAQPQM FLNISWQRIC*VRKTLSSWQNSSISYGRRSCCST STVPKRKWSDCCPPDKGFLCLETCSTNCQKALT QRT*RT*SSF*KTRFPKLK*PP*VSWHF*RNKV K*MKII*HAWRTSAKQLYLNF*ET*RNTKERKLS R**HLL*TRKPSRIKERKN*FPKQMLRHSWKPY RRSPGKISMQVVMVTEPQMVHQAWSPGGCKEHL LTL*TLKPAQRGQLCTG*IGTTEASVSLSTTTAL PP*RTDKEPIKMLRS*VMCSSGLGSQCIYTIM* RKWKWRWSCRSRSAIQPMPTGTASCSVF*PMGD LELSTLRMRPSFPFGRSCLTSQPCSALDWLKNLN SFSSRPAKVKRYSLPYPSKQML*TLSRHPLPCR TVFLPRLTSYLVWPLSQAMYPFGMWRKAAGIFS LCVII*RNWSQDMKTSYPSSLLSTMM*VEEWTNR EQRNRCPSLLSH*GKN*YSLCPWMHFHYSREFL LVLRPQTNHWL*PPASCPAQESVVSTCHSRNRK HRVF*HSQF*FSFSFASLNVRKLSFFWR*SHSVT QTGVQGGNHGSL*SRPPRLKLSSRLSFPSSWDH RCVPPCPDFFYSLFFVEMEGSHFVAQAGFKLLG PSDPPTSVPKILGL*ARATTPGQKTFIIEDLDCS LGFGCLF*RQSNWLWFVQVLFL*DRVTPSPGLE CSGGITVHCSLDLPGSSDPPTSASQVAETTGVC PCTANFLFFLWRWGFTMLPKLVSNSWAQAILPPQ LLKVLGLQA*NTVPGLGTRCILRFLGVQKPRS* PRLSLDCLSRQLPLSYNSVSPLHALKHWTVRSQ STHPLSDLPLPKTSLLHI**GENLVYARPISCFC VRKVLT*EVFIWLETGFPVGR*WLIYTQLLCKQ KLYNLMSYSILDWVR*LMPVIPVLWEAKAGRSL EVRSSRPAWPIRQNLIITKNTKISQVWRRAPVIP ATREAETGESLESRRQRLW*AKMTQLHSSLGNR ARPCLKKKFNIGVGTFQLPLTEHPIQID*SKEG NLLPLSH*NPGVDNTGFRQSLNQDSIYRPAPFSW PDVLRAGRCSRLQWTVPTLLLLLHFAPLAQGMR REAVSETEAVLRITGLFLAEGMSGLPEGSGSVR TP*CFLH*DFEHFYVLELFFFFFSISRGTFSLLI PGTVF*ILKGEPS*GDPKSCG*RLHL*MRQLRP GDVNNLLTVLIYWI*LQPGELECLGAWKGIRSV SFDM*MLIKKCQGMKNNNSQWCLHL*LFM*KSNS CTVNLL*EYSQEHCSDISDCHVDLNVA*QRECL IYIDRAGTPSS*TNTATLSSSSLS

Sequence CASP10.aAug05

AAGGAAATGGAGATCCAAAGGAAAGCCTGAAGCACTTTGTGGCTTCCACGGGTTCGTTTCTAGGAAGCTTTTGCTTTACCTGGGGAAACCCCAAGCTCTA CAGTGAGAAAGTTGTAAATTAGCCTTTAGGAGACGCTGTTTGTCAAAGTTATCTTAACCCTGGAAAAGGGGAGGGAAAAAGGCAGATAAGCAGTGATGAC ATCAGCAGGAAACTAGTATCAGGCTACCCAGTCCTGAAGATTCAGTTTTCACTTAAACAACCAGCAAGTCTTGAAGTCTCTTCCCAAGCAAATGGGAGCT TCTTTGGACCTTGGAGCACACAGAGGATTCTACTTTCTTTAAAACTTTGTTTTCAGGCAATTTCCCTGAGAACCGTTTACTTCCAGAAGATTGGTGGAGC TTGATCTGAAGGCTGGCCATGAAATCTCAAGGTCAACATTGGTATTCCAGTTCAGATAAAAACTGTAAAGTGAGCTTTCGTGAGAAGCTTCTGATTATTG ATTCAAACCTGGGGGTCCAAGATGTGGAGAACCTCAAGTTTCTCTGCATAGGATTGGTCCCCAACAAGAAGCTGGAGAAGTCCAGCTCAGCCTCAGATGT TTTTGAACATCTCTTGGCAGAGGATCTGCTGAGTGAGGAAGACCCTTTCTTCCTGGCAGAACTCCTCTATATCATACGGCAGAAGAAGCTGCTGCAGCAC CTCAACTGTACCAAAGAGGAAGTGGAGCGACTGCTGCCCACCCGACAAAGGGTTTCTCTGTTTAGAAACCTGCTCTACGAACTGTCAGAAGGCATTGACT CAGAGAACTTAAAGGACATGATCTTCCTTCTGAAAGACTCGCTTCCCAAAACTGAAATGACCTCCCTAAGTTTCCTGGCATTTCTAGAGAAACAAGGTAA AATAGATGAAGATAATCTGACATGCCTGGAGGACCTCTGCAAAACAGTTGTACCTAAACTTTTGAGAAACATAGAGAAATACAAAAGAGAGAAAGCTATC CAGATAGTGACACCTCCTGTAGACAAGGAAGCCGAGTCGTATCAAGGAGAGGAAGAACTAGTTTCCCAAACAGATGTTAAGACATTCTTGGAAGCCTTAC CGCAGGAGTCCTGGCAAAATAAGCATGCAGGTAGTAATGGTAACAGAGCCACAAATGGTGCACCAAGCCTGGTCTCCAGGGGGATGCAAGGAGCATCTGC TAACACTCTAAACTCTGAAACCAGCACAAAGAGGGCAGCTGTGTACAGGATGAATCGGAACCACAGAGGCCTCTGTGTCATTGTCAACAACCACAGCTTT ACCTCCCTGAAGGACAGACAAGGAACCCATAAAGATGCTGAGATCCTGAGTCATGTGTTCCAGTGGCTTGGGTTCACAGTGCATATACACAATAATGTGA CGAAAGTGGAAATGGAGATGGTCCTGCAGAAGCAGAAGTGCAATCCAGCCCATGCCGACGGGGACTGCTTCGTGTTCTGTATTCTGACCCATGGGAGATT TGGAGCTGTCTACTCTTCGGATGAGGCCCTCATTCCCATTCGGGAGATCATGTCTCACTTCACAGCCCTGCAGTGCCCTAGACTGGCTGAAAAACCTAAA CTCTTTTTCATCCAGGCCTGCCAAGGTGAAGAGATACAGCCTTCCGTATCCATCGAAGCAGATGCTCTGAACCCTGAGCAGGCACCCACTTCCCTGCAGG ACAGTATTCCTGCCGAGGCTGACTTCCTACTTGGTCTGGCCACTGTCCCAGGCTATGTATCCTTTCGGCATGTGGAGGAAGGCAGCTGGTATATTCAGTC TCTGTGTAATCATCTGAAGAAATTGGTCCCAAGACATGAAGACATCTTATCCATCCTCACTGCTGTCAACGATGATGTGAGTCGAAGAGTGGACAAACAG GGAACAAAGAAACAGATGCCCCAGCCTGCTTTCACACTAAGGAAAAAACTAGTATTCCCTGTGCCCCTGGATGCACTTTCATTATAGCAGAGAGTTTTTG TTGGTTCTTAGACCTCAAACGAATCATTGGCTATAACCTCCAGCCTCCTGCCCAGCACAGGAATCGGTGGTCTCCACCTGTCATTCTAGAAACAGGAAAC ACCGTGTTTTCTGACACAGTCAATTCTGATTTTCTTTTTCTTTTGCAAGTCTAAATGTTAGAAAACTTTCTTTTTTTTGGAGATAGTCTCATTCTGTCAC CCAGACTGGAGTGCAGGGGGGCAATCACGGCTCACTGTAGTCTCGACCTCCCAGGTTCAAGCGATCCTCCCACCTCAGCCTCCCAAGTAGCTGAGACTAC AGGTGTGTGTCCATGCACAGCTAACTTTTTATTTTTTTTGTGGAGATGGGGTTTCACTATGTTGCCTAAGCTGGTCTCAAACTCCTGGGCTCAAGCGATC CTCCCACCTCAGCTTCTCAAAGTTCTGGGACTACAGGCATGAAATACTGTGCCTGGCCTGGGGACCAGGTGCATTTTAAGGTTCCTTGGTGTTCAAAAAC CACGTTCTTAGCCTAGATTGAGCTTAGATTGCCTCTCTAGACAACTACCCCTTAGTTATAATTCTGTGTCCCCTCTGCATGCCCTTAAACATTGGACAGT GAGGTCACAGTCCACCCACCCTCTCTCTGATCTCCCCCTTCCTAAGACTTCTCTTTTGCACATCTAGTGAGGTGAAAATTTGGTCTATGCCAGGCCCATT TCCTGCTTTTGTGTAAGGAAGGTGCTCACATAGGAAGTTTTTATTTGGTTAGAGACAGGTTTCCCTGTAGGAAGATGATGGCTCATTTACACTCAGCTGC TCTGCAAGCAGAAACTTTACAACCTGATGTCATATTCCATTTTGGACTGGGTGCGGTGACTCATGCCTGTAATCCCAGTACTCTGGGAAGCCAAGGCAGG CAGATCACTTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAATACGGCAAAACCTCATCATTACTAAAAACACAAAAATTAGCCAGGTGTGGCGGCGAGCA CCTGTAATCCCAGCTACTCGGGAGGCTGAGACAGGAGAATCTCTTGAATCCAGGAGGCAGAGGCTGTGGTGAGCCAAGATGACACAACTGCACTCCAGCT TGGGCAACAGGGCGAGACCTTGTTTAAAAAAAAAATTCAATATTGGGGTTGGAACATTTCAGTTGCCATTGACAGAACACCCAATTCAAATTGACTGAAG CAAAGAAGGGAATTTATTGCCTCTTTCACATTGAAACCCAGGAGTGGATAACACTGGCTTCAGGCAAAGCTTGAATCAGGACTCAATCTACAGGCCAGCA CCTTTCTCTTGGCCGGATGTCCTCAGGGCTGGCAGATGCAGTAGACTGCAGTGGACAGTCCCCACCTTGTTACTGCTACTACACTTTGCTCCTCTGGCCC AAGGCATGAGGAGAGAGGCTGTGTCAGAAACTGAAGCTGTTCTCAGGATCACTGGGCTCTTCTTGGCAGAGGGGATGTCTGGCTTGCCTGAAGGGAGTGG CTCTGTAAGGACGCCTTGATGCTTTCTTCATTAAGATTTTGAGCATTTTTACGTACTTGAGCTTTTTTTTTTTTTTTTTTCAATTTCTAGAGGAACTTTT TCTCTGTTAATTCCTGGAACTGTATTTTGAATCCTTAAAGGTGAGCCCTCATAGGGAGATCCAAAGTCCTGTGGTTAACGCCTTCATTTATAGATGAGGC AGCTGAGGCCTGGGGATGTGAACAACCTGCTCACAGTCCTCATTTACTGGATTTGACTTCAGCCAGGTGAACTGGAATGCCTTGGGGCGTGGAAGGGCAT TAGGAGTGTTTCATTTGATATGTGAATGCTCATAAAAAAATGTCAAGGAATGAAGAACAACAACTCTCAGTGGTGCCTGCATTTATAATTATTTATGTGA AAGTCAAATTCATGTACAGTAAATTTGTTATAAGAATATTCACAAGAACACTGTTCTGATATCTCTGATTGTCATGTGGATTTGAATGTAGCTTGACAGA GGGAATGTCTAATCTATATTGACAGGGCAGGAACACCGTCATCTTAGACAAACACCGCCACTTTAAGTTCCAGTTCCCTTTCTAG

CASP10.b.f.23 (forward primer)
CASP10.u.r.15 (reverse primer)
Single exon skipping

Frame 0

KEMEIQRKA*STLWLPRVRF*EAFALPGETPSS TVRKL*ISL*ETLFVKVILTLEKGREKGR*AVMT SAGN*YQATQS*RFSFHLNNQQVLKSLPKQMGA SLDLGAHRGFYFL*NFVFRQFP*EPFTSRRLVE LDLKAGHEISRSTLVFQFR*KL*SELS*EASDY* FKPGGPRCGEPQVSLHRIGPQQEAGEVQLSLRC F*TSLGRGSAE*GRPFLPGRTPLYHTAEEAAAA PQLYQRGSGATAAHPTKGFSV*KPALRTVRRH*L RELKGHDLPSERLASQN*NDLPKFPGISRETR* NR*R*SDMPGGPLQNSCT*TFEKHREIQKRESY PDSDTSCRQGSRVVSRRGRTSFPNRC*DILGSLT AGVLAK*ACR**W*QSHKWCTKPGLQGDARSIC *HSKL*NQHKEGSCVQDESEPQRPLCHCQQPQL YLPEGQTRNP*RC*DPESCVPVAWVHSAYTQ*CD ESGNGDGPAEAEVQSSPCRRGLLRVLYSDPWEI WSCLLFG*GPHSHSGDHVSLHSPAVP*TG*KT* TLFHPGLPR*RDTAFRIHRSRCSEP*AGTHFPAG QYSCRG*LPTWSGHCPRLCILSACGGRQLVYSV SV*SSEEIGPKT*RHLIHPHCCQR*CESKSGQT GNKETDAPACFHTKEKTSIPCAPGCTFIIAESFC WFLDLKRIIGYNLQPPAQHRNRWSPPVILETGN TVFSDTVNSDFLFLLQV*MLENFLFFGDSLILS PRLECRGAITAHCSLDLPGSSDPPTSASQVAETT GVCPCTANFLFFLWRWGFTMLPKLVSNSWAQAI LPPQLLKVLGLQA*NTVPGLGTRCILRFLGVQK PRS*PRLSLDCLSRQLPLSYNSVSPLHALKHWTV RSQSTHPLSDLPLPKTSLLHI**GENLVYARPI SCFCVRKVLT*EVFIWLETGFPVGR*WLIYTQL LCKQKLYNLMSYSILDWVR*LMPVIPVLWEAKAG RSLEVRSSRPAWPIRQNLIITKNTKISQVWRRA PVIPATREAETGESLESRRQRLW*AKMTQLHSS LGNRARPCLKKKFNIGVGTFQLPLTEHPIQID*S KEGNLLPLSH*NPGVDNTGFRQSLNQDSIYRPA PFSWPDVLRAGRCSRLQWTVPTLLLLLHFAPLA QGMRREAVSETEAVLRITGLFLAEGMSGLPEGSG SVRTP*CFLH*DFEHFYVLELFFFFFSISRGTF SLLIPGTVF*ILKGEPS*GDPKSCG*RLHL*MR QLRPGDVNNLLTVLIYWI*LQPGELECLGAWKGI RSVSFDM*MLIKKCQGMKNNNSQWCLHL*LFM* KSNSCTVNLL*EYSQEHCSDISDCHVDLNVA*Q RECLIYIDRAGTPSS*TNTATLSSSSLS

Frame 1

RKWRSKGKPEALCGFHGFVSRKLLLYLGKPQAL Q*ESCKLAFRRRCLSKLS*PWKRGGKKADKQ** HQQETSIRLPSPEDSVFT*TTSKS*SLFPSKWEL LWTLEHTEDSTFFKTLFSGNFPENRLLPEDWWS LI*RLAMKSQGQHWYSSSDKNCKVSFREKLLII DSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDV FEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQH LNCTKEEVERLLPTRQRVSLFRNLLYELSEGID SENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGK IDEDNLTCLEDLCKTVVPKLLRNIEKYKREKAI QIVTPPVDKEAESYQGEEELVSQTDVKTFLEAL PQESWQNKHAGSNGNRATNGAPSLVSRGMQGASA NTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSF TSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNV TKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRF GAVYSSDEALIPIREIMSHFTALQCPRLAEKPK LFFIQACQGEEIQPSVSIEADALNPEQAPTSLQ DSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQS LCNHLKKLVPRHEDILSILTAVNDDVSRRVDKQ GTKKQMPQPAFTLRKKLVFPVPLDALSL*QRVF VGS*TSNESLAITSSLLPSTGIGGLHLSF*KQET PCFLTQSILIFFFFCKSKC*KTFFFLEIVSFCH PDWSAGGQSRLTVVSTSQVQAILPPQPPK*LRL QVCVHAQLTFYFFCGDGVSLCCLSWSQTPGLKRS SHLSFSKFWDYRHEILCLAWGPGAF*GSLVFKN HVLSLD*A*IASLDNYPLVIILCPLCMPLNIGQ *GHSPPTLSLISPFLRLLFCTSSEVKIWSMPGPF PAFV*GRCSHRKFLFG*RQVSL*EDDGSFTLSC SASRNFTT*CHIPFWTGCGDSCL*SQYSGKPRQ ADHLRSGVRDQPGQYGKTSSLLKTQKLARCGGEH L*SQLLGRLRQENLLNPGGRGCGEPR*HNCTPA WATGRDLV*KKNSILGLEHFSCH*QNTQFKLTE AKKGIYCLFHIETQEWITLASGKA*IRTQSTGQH LSLGRMSSGLADAVDCSGQSPPCYCYYTLLLWP KA*GERLCQKLKLFSGSLGSSWQRGCLACLKGV AL*GRLDAFFIKILSIFTYLSFFFFFFQFLEELF LC*FLELYFESLKVSPHREIQSPVVNAFIYR*G S*GLGM*TTCSQSSFTGFDFSQVNWNALGRGRA LGVFHLICECS*KNVKE*RTTTLSGACIYNYLCE SQIHVQ*ICYKNIHKNTVLISLIVMWI*M*LDR GNV*SILTGQEHRHLRQTPPL*VPVPFL

Frame 2

GNGDPKESLKHFVASTGSFLGSFCFTWGNPKLY SEKVVN*PLGDAVCQSYLNPGKGEGKRQISSDD ISRKLVSGYPVLKIQFSLKQPASLEVSSQANGS FFGPWSTQRILLSLKLCFQAISLRTVYFQKIGGA *SEGWP*NLKVNIGIPVQIKTVK*AFVRSF*LL IQTWGSKMWRTSSFSA*DWSPTRSWRSPAQPQM FLNISWQRIC*VRKTLSSWQNSSISYGRRSCCST STVPKRKWSDCCPPDKGFLCLETCSTNCQKALT QRT*RT*SSF*KTRFPKLK*PP*VSWHF*RNKV K*MKII*HAWRTSAKQLYLNF*ET*RNTKERKLS R**HLL*TRKPSRIKERKN*FPKQMLRHSWKPY RRSPGKISMQVVMVTEPQMVHQAWSPGGCKEHL LTL*TLKPAQRGQLCTG*IGTTEASVSLSTTTAL PP*RTDKEPIKMLRS*VMCSSGLGSQCIYTIM* RKWKWRWSCRSRSAIQPMPTGTASCSVF*PMGD LELSTLRMRPSFPFGRSCLTSQPCSALDWLKNLN SFSSRPAKVKRYSLPYPSKQML*TLSRHPLPCR TVFLPRLTSYLVWPLSQAMYPFGMWRKAAGIFS LCVII*RNWSQDMKTSYPSSLLSTMM*VEEWTNR EQRNRCPSLLSH*GKN*YSLCPWMHFHYSREFL LVLRPQTNHWL*PPASCPAQESVVSTCHSRNRK HRVF*HSQF*FSFSFASLNVRKLSFFWR*SHSVT QTGVQGGNHGSL*SRPPRFKRSSHLSLPSS*DY RCVSMHS*LFIFFVEMGFHYVA*AGLKLLGSSD PPTSASQSSGTTGMKYCAWPGDQVHFKVPWCSKT TFLA*IELRLPL*TTTP*L*FCVPSACP*TLDS EVTVHPPSL*SPPS*DFSFAHLVR*KFGLCQAH FLLLCKEGAHIGSFYLVRDRFPCRKMMAHLHSAA LQAETLQPDVIFHFGLGAVTHACNPSTLGSQGR QIT*GQEFETSLANTAKPHHY*KHKN*PGVAAS TCNPSYSGG*DRRIS*IQEAEAVVSQDDTTALQL GQQGETLFKKKIQYWGWNISVAIDRTPNSN*LK QRREFIASFTLKPRSG*HWLQAKLESGLNLQAS TFLLAGCPQGWQMQ*TAVDSPHLVTATTLCSSGP RHEERGCVRN*SCSQDHWALLGRGDVWLA*REW LCKDALMLSSLRF*AFLRT*AFFFFFFNF*RNF FSVNSWNCILNP*R*ALIGRSKVLWLTPSFIDEA AEAWGCEQPAHSPHLLDLTSAR*TGMPWGVEGH *ECFI*YVNAHKKMSRNEEQQLSVVPAFIIIYV KVKFMYSKFVIRIFTRTLF*YL*LSCGFECSLTE GMSNLY*QGRNTVILDKHRHFKFQFPF*