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Sequences

Sequence CASP10.eAug05

CASP10.b.f.23 (forward primer)
CASP10.u.r.15 (reverse primer)
Multiple exon skipping

Frame 0

Frame 1

Frame 2

Sequence CASP10.dAug05

AAGGAAATGGAGATCCAAAGGAAAGCCTGAAGCACTTTGTGGCTTCCACGGGTTCGTTTCTAGGAAGCTTTTGCTTTACCTGGGGAAACCCCAAGCTCTA CAGTGAGAAAGTTGTAAATTAGCCTTTAGGAGACGCTGTTTGTCAAAGTTATCTTAACCCTGGAAAAGGGGAGGGAAAAAGGCAGATAAGCAGTGATGAC ATCAGCAGGAAACTAGTATCAGGCTACCCAGTCCTGAAGATTCAGTTTTCACTTAAACAACCAGCAAGTCTTGAAGTCTCTTCCCAAGCAAATGGGAGCT TCTTTGGACCTTGGAGCACACAGAGGATTCTACTTTCTTTAAAACTTTGTTTTCAGGCAATTTCCCTGAGAACCGTTTACTTCCAGAAGATTGGTGGAGC TTGATCTGAAGGCTGGCCATGAAATCTCAAGGTCAACATTGGTATTCCAGTTCAGATAAAAACTGTAAAGTGAGCTTTCGTGAGAAGCTTCTGATTATTG ATTCAAACCTGGGGGTCCAAGATGTGGAGAACCTCAAGTTTCTCTGCATAGGATTGGTCCCCAACAAGAAGCTGGAGAAGTCCAGCTCAGCCTCAGATGT TTTTGAACATCTCTTGGCAGAGGATCTGCTGAGTGAGGAAGACCCTTTCTTCCTGGCAGAACTCCTCTATATCATACGGCAGAAGAAGCTGCTGCAGCAC CTCAACTGTACCAAAGAGGAAGTGGAGCGACTGCTGCCCACCCGACAAAGGGTTTCTCTGTTTAGAAACCTGCTCTACGAACTGTCAGAAGGCATTGACT CAGAGAACTTAAAGGACATGATCTTCCTTCTGAAAGACTCGCTTCCCAAAACTGAAATGACCTCCCTAAGTTTCCTGGCATTTCTAGAGAAACAAGGTAA AATAGATGAAGATAATCTGACATGCCTGGAGGACCTCTGCAAAACAGTTGTACCTAAACTTTTGAGAAACATAGAGAAATACAAAAGAGAGAAAGCTATC CAGATAGTGACACCTCCTGTAGACAAGGAAGCCGAGTCGTATCAAGGAGAGGAAGAACTAGTTTCCCAAACAGATGTTAAGACATTCTTGGAAGCCTTAC CGAGGGCAGCTGTGTACAGGATGAATCGGAACCACAGAGGCCTCTGTGTCATTGTCAACAACCACAGCTTTACCTCCCTGAAGGACAGACAAGGAACCCA TAAAGATGCTGAGATCCTGAGTCATGTGTTCCAGTGGCTTGGGTTCACAGTGCATATACACAATAATGTGACGAAAGTGGAAATGGAGATGGTCCTGCAG AAGCAGAAGTGCAATCCAGCCCATGCCGACGGGGACTGCTTCGTGTTCTGTATTCTGACCCATGGGAGATTTGGAGCTGTCTACTCTTCGGATGAGGCCC TCATTCCCATTCGGGAGATCATGTCTCACTTCACAGCCCTGCAGTGCCCTAGACTGGCTGAAAAACCTAAACTCTTTTTCATCCAGGCCTGCCAAGGTGA AGAGATACAGCCTTCCGTATCCATCGAAGCAGATGCTCTGAACCCTGAGCAGGCACCCACTTCCCTGCAGGACAGTATTCCTGCCGAGGCTGACTTCCTA CTTGGTCTGGCCACTGTCCCAGGCTATGTATCCTTTCGGCATGTGGAGGAAGGCAGCTGGTATATTCAGTCTCTGTGTAATCATCTGAAGAAATTGGTCC CAAGACATGAAGACATCTTATCCATCCTCACTGCTGTCAACGATGATGTGAGTCGAAGAGTGGACAAACAGGGAACAAAGAAACAGATGCCCCAGCCTGC TTTCACACTAAGGAAAAAACTAGTATTCCCTGTGCCCCTGGATGCACTTTCATTATAGCAGAGAGTTTTTGTTGGTTCTTAGACCTCAAACGAATCATTG GCTATAACCTCCAGCCTCCTGCCCAGCACAGGAATCGGTGGTCTCCACCTGTCATTCTAGAAACAGGAAACACCGTGTTTTCTGACACAGTCAATTCTGA TTTTCTTTTTCTTTTGCAAGTCTAAATGTTAGAAAACTTTCTTTTTTTTGGAGATAGTCTCATTCTGTCACCCAGACTGGAGTGCAGGGGGGCAATCACG GCTCACTGTAGTCTCGACCTCCCAGGTTCAAGCGATCCTCCCACCTCAGCCTCCCAAGTAGCTGAGACTACAGGTGTGTGTCCATGCACAGCTAACTTTT TATTTTTTTTGTGGAGATGGGGTTTCACTATGTTGCCTAAGCTGGTCTCAAACTCCTGGGCTCAAGCGATCCTCCCACCTCAGCTTCTCAAAGTTCTGGG ACTACAGGCATGAAATACTGTGCCTGGCCTGGGGACCAGGTGCATTTTAAGGTTCCTTGGTGTTCAAAAACCACGTTCTTAGCCTAGATTGAGCTTAGAT TGCCTCTCTAGACAACTACCCCTTAGTTATAATTCTGTGTCCCCTCTGCATGCCCTTAAACATTGGACAGTGAGGTCACAGTCCACCCACCCTCTCTCTG ATCTCCCCCTTCCTAAGACTTCTCTTTTGCACATCTAGTGAGGTGAAAATTTGGTCTATGCCAGGCCCATTTCCTGCTTTTGTGTAAGGAAGGTGCTCAC ATAGGAAGTTTTTATTTGGTTAGAGACAGGTTTCCCTGTAGGAAGATGATGGCTCATTTACACTCAGCTGCTCTGCAAGCAGAAACTTTACAACCTGATG TCATATTCCATTTTGGACTGGGTGCGGTGACTCATGCCTGTAATCCCAGTACTCTGGGAAGCCAAGGCAGGCAGATCACTTGAGGTCAGGAGTTCGAGAC CAGCCTGGCCAATACGGCAAAACCTCATCATTACTAAAAACACAAAAATTAGCCAGGTGTGGCGGCGAGCACCTGTAATCCCAGCTACTCGGGAGGCTGA GACAGGAGAATCTCTTGAATCCAGGAGGCAGAGGCTGTGGTGAGCCAAGATGACACAACTGCACTCCAGCTTGGGCAACAGGGCGAGACCTTGTTTAAAA AAAAAATTCAATATTGGGGTTGGAACATTTCAGTTGCCATTGACAGAACACCCAATTCAAATTGACTGAAGCAAAGAAGGGAATTTATTGCCTCTTTCAC ATTGAAACCCAGGAGTGGATAACACTGGCTTCAGGCAAAGCTTGAATCAGGACTCAATCTACAGGCCAGCACCTTTCTCTTGGCCGGATGTCCTCAGGGC TGGCAGATGCAGTAGACTGCAGTGGACAGTCCCCACCTTGTTACTGCTACTACACTTTGCTCCTCTGGCCCAAGGCATGAGGAGAGAGGCTGTGTCAGAA ACTGAAGCTGTTCTCAGGATCACTGGGCTCTTCTTGGCAGAGGGGATGTCTGGCTTGCCTGAAGGGAGTGGCTCTGTAAGGACGCCTTGATGCTTTCTTC ATTAAGATTTTGAGCATTTTTACGTACTTGAGCTTTTTTTTTTTTTTTTTTCAATTTCTAGAGGAACTTTTTCTCTGTTAATTCCTGGAACTGTATTTTG AATCCTTAAAGGTGAGCCCTCATAGGGAGATCCAAAGTCCTGTGGTTAACGCCTTCATTTATAGATGAGGCAGCTGAGGCCTGGGGATGTGAACAACCTG CTCACAGTCCTCATTTACTGGATTTGACTTCAGCCAGGTGAACTGGAATGCCTTGGGGCGTGGAAGGGCATTAGGAGTGTTTCATTTGATATGTGAATGC TCATAAAAAAATGTCAAGGAATGAAGAACAACAACTCTCAGTGGTGCCTGCATTTATAATTATTTATGTGAAAGTCAAATTCATGTACAGTAAATTTGTT ATAAGAATATTCACAAGAACACTGTTCTGATATCTCTGATTGTCATGTGGATTTGAATGTAGCTTGACAGAGGGAATGTCTAATCTATATTGACAGGGCA GGAACACCGTCATCTTAGACAAACACCGCCACTTTAAGTTCCAGTTCCCTTTCTAG

CASP10.b.f.23 (forward primer)
CASP10.u.r.15 (reverse primer)
Multiple exon skipping

Frame 0

KEMEIQRKA*STLWLPRVRF*EAFALPGETPSS TVRKL*ISL*ETLFVKVILTLEKGREKGR*AVMT SAGN*YQATQS*RFSFHLNNQQVLKSLPKQMGA SLDLGAHRGFYFL*NFVFRQFP*EPFTSRRLVE LDLKAGHEISRSTLVFQFR*KL*SELS*EASDY* FKPGGPRCGEPQVSLHRIGPQQEAGEVQLSLRC F*TSLGRGSAE*GRPFLPGRTPLYHTAEEAAAA PQLYQRGSGATAAHPTKGFSV*KPALRTVRRH*L RELKGHDLPSERLASQN*NDLPKFPGISRETR* NR*R*SDMPGGPLQNSCT*TFEKHREIQKRESY PDSDTSCRQGSRVVSRRGRTSFPNRC*DILGSLT EGSCVQDESEPQRPLCHCQQPQLYLPEGQTRNP *RC*DPESCVPVAWVHSAYTQ*CDESGNGDGPA EAEVQSSPCRRGLLRVLYSDPWEIWSCLLFG*GP HSHSGDHVSLHSPAVP*TG*KT*TLFHPGLPR* RDTAFRIHRSRCSEP*AGTHFPAGQYSCRG*LP TWSGHCPRLCILSACGGRQLVYSVSV*SSEEIGP KT*RHLIHPHCCQR*CESKSGQTGNKETDAPAC FHTKEKTSIPCAPGCTFIIAESFCWFLDLKRII GYNLQPPAQHRNRWSPPVILETGNTVFSDTVNSD FLFLLQV*MLENFLFFGDSLILSPRLECRGAIT AHCSLDLPGSSDPPTSASQVAETTGVCPCTANF LFFLWRWGFTMLPKLVSNSWAQAILPPQLLKVLG LQA*NTVPGLGTRCILRFLGVQKPRS*PRLSLD CLSRQLPLSYNSVSPLHALKHWTVRSQSTHPLS DLPLPKTSLLHI**GENLVYARPISCFCVRKVLT *EVFIWLETGFPVGR*WLIYTQLLCKQKLYNLM SYSILDWVR*LMPVIPVLWEAKAGRSLEVRSSR PAWPIRQNLIITKNTKISQVWRRAPVIPATREAE TGESLESRRQRLW*AKMTQLHSSLGNRARPCLK KKFNIGVGTFQLPLTEHPIQID*SKEGNLLPLS H*NPGVDNTGFRQSLNQDSIYRPAPFSWPDVLRA GRCSRLQWTVPTLLLLLHFAPLAQGMRREAVSE TEAVLRITGLFLAEGMSGLPEGSGSVRTP*CFL H*DFEHFYVLELFFFFFSISRGTFSLLIPGTVF* ILKGEPS*GDPKSCG*RLHL*MRQLRPGDVNNL LTVLIYWI*LQPGELECLGAWKGIRSVSFDM*M LIKKCQGMKNNNSQWCLHL*LFM*KSNSCTVNLL *EYSQEHCSDISDCHVDLNVA*QRECLIYIDRA GTPSS*TNTATLSSSSLS

Frame 1

RKWRSKGKPEALCGFHGFVSRKLLLYLGKPQAL Q*ESCKLAFRRRCLSKLS*PWKRGGKKADKQ** HQQETSIRLPSPEDSVFT*TTSKS*SLFPSKWEL LWTLEHTEDSTFFKTLFSGNFPENRLLPEDWWS LI*RLAMKSQGQHWYSSSDKNCKVSFREKLLII DSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDV FEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQH LNCTKEEVERLLPTRQRVSLFRNLLYELSEGID SENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGK IDEDNLTCLEDLCKTVVPKLLRNIEKYKREKAI QIVTPPVDKEAESYQGEEELVSQTDVKTFLEAL PRAAVYRMNRNHRGLCVIVNNHSFTSLKDRQGTH KDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQ KQKCNPAHADGDCFVFCILTHGRFGAVYSSDEA LIPIREIMSHFTALQCPRLAEKPKLFFIQACQGE EIQPSVSIEADALNPEQAPTSLQDSIPAEADFL LGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLV PRHEDILSILTAVNDDVSRRVDKQGTKKQMPQPA FTLRKKLVFPVPLDALSL*QRVFVGS*TSNESL AITSSLLPSTGIGGLHLSF*KQETPCFLTQSIL IFFFFCKSKC*KTFFFLEIVSFCHPDWSAGGQSR LTVVSTSQVQAILPPQPPK*LRLQVCVHAQLTF YFFCGDGVSLCCLSWSQTPGLKRSSHLSFSKFW DYRHEILCLAWGPGAF*GSLVFKNHVLSLD*A*I ASLDNYPLVIILCPLCMPLNIGQ*GHSPPTLSL ISPFLRLLFCTSSEVKIWSMPGPFPAFV*GRCS HRKFLFG*RQVSL*EDDGSFTLSCSASRNFTT*C HIPFWTGCGDSCL*SQYSGKPRQADHLRSGVRD QPGQYGKTSSLLKTQKLARCGGEHL*SQLLGRL RQENLLNPGGRGCGEPR*HNCTPAWATGRDLV*K KNSILGLEHFSCH*QNTQFKLTEAKKGIYCLFH IETQEWITLASGKA*IRTQSTGQHLSLGRMSSG LADAVDCSGQSPPCYCYYTLLLWPKA*GERLCQK LKLFSGSLGSSWQRGCLACLKGVAL*GRLDAFF IKILSIFTYLSFFFFFFQFLEELFLC*FLELYF ESLKVSPHREIQSPVVNAFIYR*GS*GLGM*TTC SQSSFTGFDFSQVNWNALGRGRALGVFHLICEC S*KNVKE*RTTTLSGACIYNYLCESQIHVQ*IC YKNIHKNTVLISLIVMWI*M*LDRGNV*SILTGQ EHRHLRQTPPL*VPVPFL

Frame 2

GNGDPKESLKHFVASTGSFLGSFCFTWGNPKLY SEKVVN*PLGDAVCQSYLNPGKGEGKRQISSDD ISRKLVSGYPVLKIQFSLKQPASLEVSSQANGS FFGPWSTQRILLSLKLCFQAISLRTVYFQKIGGA *SEGWP*NLKVNIGIPVQIKTVK*AFVRSF*LL IQTWGSKMWRTSSFSA*DWSPTRSWRSPAQPQM FLNISWQRIC*VRKTLSSWQNSSISYGRRSCCST STVPKRKWSDCCPPDKGFLCLETCSTNCQKALT QRT*RT*SSF*KTRFPKLK*PP*VSWHF*RNKV K*MKII*HAWRTSAKQLYLNF*ET*RNTKERKLS R**HLL*TRKPSRIKERKN*FPKQMLRHSWKPY RGQLCTG*IGTTEASVSLSTTTALPP*RTDKEP IKMLRS*VMCSSGLGSQCIYTIM*RKWKWRWSCR SRSAIQPMPTGTASCSVF*PMGDLELSTLRMRP SFPFGRSCLTSQPCSALDWLKNLNSFSSRPAKV KRYSLPYPSKQML*TLSRHPLPCRTVFLPRLTSY LVWPLSQAMYPFGMWRKAAGIFSLCVII*RNWS QDMKTSYPSSLLSTMM*VEEWTNREQRNRCPSL LSH*GKN*YSLCPWMHFHYSREFLLVLRPQTNHW L*PPASCPAQESVVSTCHSRNRKHRVF*HSQF* FSFSFASLNVRKLSFFWR*SHSVTQTGVQGGNH GSL*SRPPRFKRSSHLSLPSS*DYRCVSMHS*LF IFFVEMGFHYVA*AGLKLLGSSDPPTSASQSSG TTGMKYCAWPGDQVHFKVPWCSKTTFLA*IELR LPL*TTTP*L*FCVPSACP*TLDSEVTVHPPSL* SPPS*DFSFAHLVR*KFGLCQAHFLLLCKEGAH IGSFYLVRDRFPCRKMMAHLHSAALQAETLQPD VIFHFGLGAVTHACNPSTLGSQGRQIT*GQEFET SLANTAKPHHY*KHKN*PGVAASTCNPSYSGG* DRRIS*IQEAEAVVSQDDTTALQLGQQGETLFK KKIQYWGWNISVAIDRTPNSN*LKQRREFIASFT LKPRSG*HWLQAKLESGLNLQASTFLLAGCPQG WQMQ*TAVDSPHLVTATTLCSSGPRHEERGCVR N*SCSQDHWALLGRGDVWLA*REWLCKDALMLSS LRF*AFLRT*AFFFFFFNF*RNFFSVNSWNCIL NP*R*ALIGRSKVLWLTPSFIDEAAEAWGCEQP AHSPHLLDLTSAR*TGMPWGVEGH*ECFI*YVNA HKKMSRNEEQQLSVVPAFIIIYVKVKFMYSKFV IRIFTRTLF*YL*LSCGFECSLTEGMSNLY*QG RNTVILDKHRHFKFQFPF*

Sequence CASP10.cAug05

CASP10.b.f.23 (forward primer)
CASP10.u.r.15 (reverse primer)
Multiple exon skipping

Frame 0

Frame 1

Frame 2

Sequence CASP10.bAug05

AAGGAAATGGAGATCCAAAGGAAAGCCTGAAGCACTTTGTGGCTTCCACGGGTTCGTTTCTAGGAAGCTTTTGCTTTACCTGGGGAAACCCCAAGCTCTA CAGTGAGAAAGTTGTAAATTAGCCTTTAGGAGACGCTGTTTGTCAAAGTTATCTTAACCCTGGAAAAGGGGAGGGAAAAAGGCAGATAAGCAGTGATGAC ATCAGCAGGAAACTAGTATCAGGCTACCCAGTCCTGAAGATTCAGTTTTCACTTAAACAACCAGCAAGTCTTGAAGTCTCTTCCCAAGCAAATGGGAGCT TCTTTGGACCTTGGAGCACACAGAGGATTCTACTTTCTTTAAAACTTTGTTTTCAGGCAATTTCCCTGAGAACCGTTTACTTCCAGAAGATTGGTGGAGC TTGATCTGAAGGCTGGCCATGAAATCTCAAGGTCAACATTGGTATTCCAGTTCAGATAAAAACTGTAAAGTGAGCTTTCGTGAGAAGCTTCTGATTATTG ATTCAAACCTGGGGGTCCAAGATGTGGAGAACCTCAAGTTTCTCTGCATAGGATTGGTCCCCAACAAGAAGCTGGAGAAGTCCAGCTCAGCCTCAGATGT TTTTGAACATCTCTTGGCAGAGGATCTGCTGAGTGAGGAAGACCCTTTCTTCCTGGCAGAACTCCTCTATATCATACGGCAGAAGAAGCTGCTGCAGCAC CTCAACTGTACCAAAGAGGAAGTGGAGCGACTGCTGCCCACCCGACAAAGGGTTTCTCTGTTTAGAAACCTGCTCTACGAACTGTCAGAAGGCATTGACT CAGAGAACTTAAAGGACATGATCTTCCTTCTGAAAGACTCGCTTCCCAAAACTGAAATGACCTCCCTAAGTTTCCTGGCATTTCTAGAGAAACAAGGTAA AATAGATGAAGATAATCTGACATGCCTGGAGGACCTCTGCAAAACAGTTGTACCTAAACTTTTGAGAAACATAGAGAAATACAAAAGAGAGAAAGCTATC CAGATAGTGACACCTCCTGTAGACAAGGAAGCCGAGTCGTATCAAGGAGAGGAAGAACTAGTTTCCCAAACAGATGTTAAGACATTCTTGGAAGCCTTAC CGCAGGAGTCCTGGCAAAATAAGCATGCAGGTAGTAATGGTAACAGAGCCACAAATGGTGCACCAAGCCTGGTCTCCAGGGGGATGCAAGGAGCATCTGC TAACACTCTAAACTCTGAAACCAGCACAAAGAGGGCAGCTGTGTACAGGATGAATCGGAACCACAGAGGCCTCTGTGTCATTGTCAACAACCACAGCTTT ACCTCCCTGAAGGACAGACAAGGAACCCATAAAGATGCTGAGATCCTGAGTCATGTGTTCCAGTGGCTTGGGTTCACAGTGCATATACACAATAATGTGA CGAAAGTGGAAATGGAGATGGTCCTGCAGAAGCAGAAGTGCAATCCAGCCCATGCCGACGGGGACTGCTTCGTGTTCTGTATTCTGACCCATGGGAGATT TGGAGCTGTCTACTCTTCGGATGAGGCCCTCATTCCCATTCGGGAGATCATGTCTCACTTCACAGCCCTGCAGTGCCCTAGACTGGCTGAAAAACCTAAA CTCTTTTTCATCCAGGCCTGCCAAGGTGAAGAGATACAGCCTTCCGTATCCATCGAAGCAGATGCTCTGAACCCTGAGCAGGCACCCACTTCCCTGCAGG ACAGTATTCCTGCCGAGGCTGACTTCCTACTTGGTCTGGCCACTGTCCCAGGCTATGTATCCTTTCGGCATGTGGAGGAAGGCAGCTGGTATATTCAGTC TCTGTGTAATCATCTGAAGAAATTGGTCCCAAGACATGAAGACATCTTATCCATCCTCACTGCTGTCAACGATGATGTGAGTCGAAGAGTGGACAAACAG GGAACAAAGAAACAGATGCCCCAGCCTGCTTTCACACTAAGGAAAAAACTAGTATTCCCTGTGCCCCTGGATGCACTTTCATTATAGCAGAGAGTTTTTG TTGGTTCTTAGACCTCAAACGAATCATTGGCTATAACCTCCAGCCTCCTGCCCAGCACAGGAATCGGTGGTCTCCACCTGTCATTCTAGAAACAGGAAAC ACCGTGTTTTCTGACACAGTCAATTCTGATTTTCTTTTTCTTTTGCAAGTCTAAATGTTAGAAAACTTTCTTTTTTTTGGAGATAGTCTCATTCTGTCAC CCAGACTGGAGTGCAGGGGGGCAATCACGGCTCACTGTAGTCTCGACCTCCCAGGCTCAAGCTGTCCTCCCGCCTCAGCTTCCCAAGTAGCTGGGACCAC AGGTGTGTACCACCGTGCCCGGATTTTTTTTATTCTTTATTTTTTGTAGAGATGGAGGGATCTCACTTTGTTGCACAGGCTGGTTTCAAACTCCTAGGCC CAAGTGATCCTCCCACCTCTGTCCCCAAAATACTGGGATTATAGGCACGAGCCACCACACCTGGCCAGAAAACTTTCATTATTGAAGACTTGGATTGTAG CCTTGGTTTTGGATGTCTATTCTGAAGACAGAGTAATTGGCTTTGGTTTGTGCAGGTACTTTTTCTTTGAGACAGAGTCACTCCGTCACCTGGGCTGGAG TGCAGTGGTGGGATCACTGTTCACTGCAGCCTTGACCTCCCAGGTTCAAGCGATCCTCCCACCTCAGCCTCCCAAGTAGCTGAGACTACAGGTGTGTGTC CATGCACAGCTAACTTTTTATTTTTTTTGTGGAGATGGGGTTTCACTATGTTGCCTAAGCTGGTCTCAAACTCCTGGGCTCAAGCGATCCTCCCACCTCA GCTTCTCAAAGTTCTGGGACTACAGGCATGAAATACTGTGCCTGGCCTGGGGACCAGGTGCATTTTAAGGTTCCTTGGTGTTCAAAAACCACGTTCTTAG CCTAGATTGAGCTTAGATTGCCTCTCTAGACAACTACCCCTTAGTTATAATTCTGTGTCCCCTCTGCATGCCCTTAAACATTGGACAGTGAGGTCACAGT CCACCCACCCTCTCTCTGATCTCCCCCTTCCTAAGACTTCTCTTTTGCACATCTAGTGAGGTGAAAATTTGGTCTATGCCAGGCCCATTTCCTGCTTTTG TGTAAGGAAGGTGCTCACATAGGAAGTTTTTATTTGGTTAGAGACAGGTTTCCCTGTAGGAAGATGATGGCTCATTTACACTCAGCTGCTCTGCAAGCAG AAACTTTACAACCTGATGTCATATTCCATTTTGGACTGGGTGCGGTGACTCATGCCTGTAATCCCAGTACTCTGGGAAGCCAAGGCAGGCAGATCACTTG AGGTCAGGAGTTCGAGACCAGCCTGGCCAATACGGCAAAACCTCATCATTACTAAAAACACAAAAATTAGCCAGGTGTGGCGGCGAGCACCTGTAATCCC AGCTACTCGGGAGGCTGAGACAGGAGAATCTCTTGAATCCAGGAGGCAGAGGCTGTGGTGAGCCAAGATGACACAACTGCACTCCAGCTTGGGCAACAGG GCGAGACCTTGTTTAAAAAAAAAATTCAATATTGGGGTTGGAACATTTCAGTTGCCATTGACAGAACACCCAATTCAAATTGACTGAAGCAAAGAAGGGA ATTTATTGCCTCTTTCACATTGAAACCCAGGAGTGGATAACACTGGCTTCAGGCAAAGCTTGAATCAGGACTCAATCTACAGGCCAGCACCTTTCTCTTG GCCGGATGTCCTCAGGGCTGGCAGATGCAGTAGACTGCAGTGGACAGTCCCCACCTTGTTACTGCTACTACACTTTGCTCCTCTGGCCCAAGGCATGAGG AGAGAGGCTGTGTCAGAAACTGAAGCTGTTCTCAGGATCACTGGGCTCTTCTTGGCAGAGGGGATGTCTGGCTTGCCTGAAGGGAGTGGCTCTGTAAGGA CGCCTTGATGCTTTCTTCATTAAGATTTTGAGCATTTTTACGTACTTGAGCTTTTTTTTTTTTTTTTTTCAATTTCTAGAGGAACTTTTTCTCTGTTAAT TCCTGGAACTGTATTTTGAATCCTTAAAGGTGAGCCCTCATAGGGAGATCCAAAGTCCTGTGGTTAACGCCTTCATTTATAGATGAGGCAGCTGAGGCCT GGGGATGTGAACAACCTGCTCACAGTCCTCATTTACTGGATTTGACTTCAGCCAGGTGAACTGGAATGCCTTGGGGCGTGGAAGGGCATTAGGAGTGTTT CATTTGATATGTGAATGCTCATAAAAAAATGTCAAGGAATGAAGAACAACAACTCTCAGTGGTGCCTGCATTTATAATTATTTATGTGAAAGTCAAATTC ATGTACAGTAAATTTGTTATAAGAATATTCACAAGAACACTGTTCTGATATCTCTGATTGTCATGTGGATTTGAATGTAGCTTGACAGAGGGAATGTCTA ATCTATATTGACAGGGCAGGAACACCGTCATCTTAGACAAACACCGCCACTTTAAGTTCCAGTTCCCTTTCTAG

CASP10.b.f.23 (forward primer)
CASP10.u.r.15 (reverse primer)
Multiple exon skipping

Frame 0

KEMEIQRKA*STLWLPRVRF*EAFALPGETPSS TVRKL*ISL*ETLFVKVILTLEKGREKGR*AVMT SAGN*YQATQS*RFSFHLNNQQVLKSLPKQMGA SLDLGAHRGFYFL*NFVFRQFP*EPFTSRRLVE LDLKAGHEISRSTLVFQFR*KL*SELS*EASDY* FKPGGPRCGEPQVSLHRIGPQQEAGEVQLSLRC F*TSLGRGSAE*GRPFLPGRTPLYHTAEEAAAA PQLYQRGSGATAAHPTKGFSV*KPALRTVRRH*L RELKGHDLPSERLASQN*NDLPKFPGISRETR* NR*R*SDMPGGPLQNSCT*TFEKHREIQKRESY PDSDTSCRQGSRVVSRRGRTSFPNRC*DILGSLT AGVLAK*ACR**W*QSHKWCTKPGLQGDARSIC *HSKL*NQHKEGSCVQDESEPQRPLCHCQQPQL YLPEGQTRNP*RC*DPESCVPVAWVHSAYTQ*CD ESGNGDGPAEAEVQSSPCRRGLLRVLYSDPWEI WSCLLFG*GPHSHSGDHVSLHSPAVP*TG*KT* TLFHPGLPR*RDTAFRIHRSRCSEP*AGTHFPAG QYSCRG*LPTWSGHCPRLCILSACGGRQLVYSV SV*SSEEIGPKT*RHLIHPHCCQR*CESKSGQT GNKETDAPACFHTKEKTSIPCAPGCTFIIAESFC WFLDLKRIIGYNLQPPAQHRNRWSPPVILETGN TVFSDTVNSDFLFLLQV*MLENFLFFGDSLILS PRLECRGAITAHCSLDLPGSSCPPASASQVAGTT GVYHRARIFFILYFL*RWRDLTLLHRLVSNS*A QVILPPLSPKYWDYRHEPPHLARKLSLLKTWIV ALVLDVYSEDRVIGFGLCRYFFFETESLRHLGWS AVVGSLFTAALTSQVQAILPPQPPK*LRLQVCV HAQLTFYFFCGDGVSLCCLSWSQTPGLKRSSHL SFSKFWDYRHEILCLAWGPGAF*GSLVFKNHVLS LD*A*IASLDNYPLVIILCPLCMPLNIGQ*GHS PPTLSLISPFLRLLFCTSSEVKIWSMPGPFPAF V*GRCSHRKFLFG*RQVSL*EDDGSFTLSCSASR NFTT*CHIPFWTGCGDSCL*SQYSGKPRQADHL RSGVRDQPGQYGKTSSLLKTQKLARCGGEHL*S QLLGRLRQENLLNPGGRGCGEPR*HNCTPAWATG RDLV*KKNSILGLEHFSCH*QNTQFKLTEAKKG IYCLFHIETQEWITLASGKA*IRTQSTGQHLSL GRMSSGLADAVDCSGQSPPCYCYYTLLLWPKA*G ERLCQKLKLFSGSLGSSWQRGCLACLKGVAL*G RLDAFFIKILSIFTYLSFFFFFFQFLEELFLC* FLELYFESLKVSPHREIQSPVVNAFIYR*GS*GL GM*TTCSQSSFTGFDFSQVNWNALGRGRALGVF HLICECS*KNVKE*RTTTLSGACIYNYLCESQI HVQ*ICYKNIHKNTVLISLIVMWI*M*LDRGNV* SILTGQEHRHLRQTPPL*VPVPFL

Frame 1

RKWRSKGKPEALCGFHGFVSRKLLLYLGKPQAL Q*ESCKLAFRRRCLSKLS*PWKRGGKKADKQ** HQQETSIRLPSPEDSVFT*TTSKS*SLFPSKWEL LWTLEHTEDSTFFKTLFSGNFPENRLLPEDWWS LI*RLAMKSQGQHWYSSSDKNCKVSFREKLLII DSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDV FEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQH LNCTKEEVERLLPTRQRVSLFRNLLYELSEGID SENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGK IDEDNLTCLEDLCKTVVPKLLRNIEKYKREKAI QIVTPPVDKEAESYQGEEELVSQTDVKTFLEAL PQESWQNKHAGSNGNRATNGAPSLVSRGMQGASA NTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSF TSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNV TKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRF GAVYSSDEALIPIREIMSHFTALQCPRLAEKPK LFFIQACQGEEIQPSVSIEADALNPEQAPTSLQ DSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQS LCNHLKKLVPRHEDILSILTAVNDDVSRRVDKQ GTKKQMPQPAFTLRKKLVFPVPLDALSL*QRVF VGS*TSNESLAITSSLLPSTGIGGLHLSF*KQET PCFLTQSILIFFFFCKSKC*KTFFFLEIVSFCH PDWSAGGQSRLTVVSTSQAQAVLPPQLPK*LGP QVCTTVPGFFLFFIFCRDGGISLCCTGWFQTPRP K*SSHLCPQNTGIIGTSHHTWPENFHY*RLGL* PWFWMSILKTE*LALVCAGTFSLRQSHSVTWAG VQWWDHCSLQP*PPRFKRSSHLSLPSS*DYRCVS MHS*LFIFFVEMGFHYVA*AGLKLLGSSDPPTS ASQSSGTTGMKYCAWPGDQVHFKVPWCSKTTFL A*IELRLPL*TTTP*L*FCVPSACP*TLDSEVTV HPPSL*SPPS*DFSFAHLVR*KFGLCQAHFLLL CKEGAHIGSFYLVRDRFPCRKMMAHLHSAALQA ETLQPDVIFHFGLGAVTHACNPSTLGSQGRQIT* GQEFETSLANTAKPHHY*KHKN*PGVAASTCNP SYSGG*DRRIS*IQEAEAVVSQDDTTALQLGQQ GETLFKKKIQYWGWNISVAIDRTPNSN*LKQRRE FIASFTLKPRSG*HWLQAKLESGLNLQASTFLL AGCPQGWQMQ*TAVDSPHLVTATTLCSSGPRHE ERGCVRN*SCSQDHWALLGRGDVWLA*REWLCKD ALMLSSLRF*AFLRT*AFFFFFFNF*RNFFSVN SWNCILNP*R*ALIGRSKVLWLTPSFIDEAAEA WGCEQPAHSPHLLDLTSAR*TGMPWGVEGH*ECF I*YVNAHKKMSRNEEQQLSVVPAFIIIYVKVKF MYSKFVIRIFTRTLF*YL*LSCGFECSLTEGMS NLY*QGRNTVILDKHRHFKFQFPF*

Frame 2

GNGDPKESLKHFVASTGSFLGSFCFTWGNPKLY SEKVVN*PLGDAVCQSYLNPGKGEGKRQISSDD ISRKLVSGYPVLKIQFSLKQPASLEVSSQANGS FFGPWSTQRILLSLKLCFQAISLRTVYFQKIGGA *SEGWP*NLKVNIGIPVQIKTVK*AFVRSF*LL IQTWGSKMWRTSSFSA*DWSPTRSWRSPAQPQM FLNISWQRIC*VRKTLSSWQNSSISYGRRSCCST STVPKRKWSDCCPPDKGFLCLETCSTNCQKALT QRT*RT*SSF*KTRFPKLK*PP*VSWHF*RNKV K*MKII*HAWRTSAKQLYLNF*ET*RNTKERKLS R**HLL*TRKPSRIKERKN*FPKQMLRHSWKPY RRSPGKISMQVVMVTEPQMVHQAWSPGGCKEHL LTL*TLKPAQRGQLCTG*IGTTEASVSLSTTTAL PP*RTDKEPIKMLRS*VMCSSGLGSQCIYTIM* RKWKWRWSCRSRSAIQPMPTGTASCSVF*PMGD LELSTLRMRPSFPFGRSCLTSQPCSALDWLKNLN SFSSRPAKVKRYSLPYPSKQML*TLSRHPLPCR TVFLPRLTSYLVWPLSQAMYPFGMWRKAAGIFS LCVII*RNWSQDMKTSYPSSLLSTMM*VEEWTNR EQRNRCPSLLSH*GKN*YSLCPWMHFHYSREFL LVLRPQTNHWL*PPASCPAQESVVSTCHSRNRK HRVF*HSQF*FSFSFASLNVRKLSFFWR*SHSVT QTGVQGGNHGSL*SRPPRLKLSSRLSFPSSWDH RCVPPCPDFFYSLFFVEMEGSHFVAQAGFKLLG PSDPPTSVPKILGL*ARATTPGQKTFIIEDLDCS LGFGCLF*RQSNWLWFVQVLFL*DRVTPSPGLE CSGGITVHCSLDLPGSSDPPTSASQVAETTGVC PCTANFLFFLWRWGFTMLPKLVSNSWAQAILPPQ LLKVLGLQA*NTVPGLGTRCILRFLGVQKPRS* PRLSLDCLSRQLPLSYNSVSPLHALKHWTVRSQ STHPLSDLPLPKTSLLHI**GENLVYARPISCFC VRKVLT*EVFIWLETGFPVGR*WLIYTQLLCKQ KLYNLMSYSILDWVR*LMPVIPVLWEAKAGRSL EVRSSRPAWPIRQNLIITKNTKISQVWRRAPVIP ATREAETGESLESRRQRLW*AKMTQLHSSLGNR ARPCLKKKFNIGVGTFQLPLTEHPIQID*SKEG NLLPLSH*NPGVDNTGFRQSLNQDSIYRPAPFSW PDVLRAGRCSRLQWTVPTLLLLLHFAPLAQGMR REAVSETEAVLRITGLFLAEGMSGLPEGSGSVR TP*CFLH*DFEHFYVLELFFFFFSISRGTFSLLI PGTVF*ILKGEPS*GDPKSCG*RLHL*MRQLRP GDVNNLLTVLIYWI*LQPGELECLGAWKGIRSV SFDM*MLIKKCQGMKNNNSQWCLHL*LFM*KSNS CTVNLL*EYSQEHCSDISDCHVDLNVA*QRECL IYIDRAGTPSS*TNTATLSSSSLS

Sequence CASP10.aAug05

AAGGAAATGGAGATCCAAAGGAAAGCCTGAAGCACTTTGTGGCTTCCACGGGTTCGTTTCTAGGAAGCTTTTGCTTTACCTGGGGAAACCCCAAGCTCTA CAGTGAGAAAGTTGTAAATTAGCCTTTAGGAGACGCTGTTTGTCAAAGTTATCTTAACCCTGGAAAAGGGGAGGGAAAAAGGCAGATAAGCAGTGATGAC ATCAGCAGGAAACTAGTATCAGGCTACCCAGTCCTGAAGATTCAGTTTTCACTTAAACAACCAGCAAGTCTTGAAGTCTCTTCCCAAGCAAATGGGAGCT TCTTTGGACCTTGGAGCACACAGAGGATTCTACTTTCTTTAAAACTTTGTTTTCAGGCAATTTCCCTGAGAACCGTTTACTTCCAGAAGATTGGTGGAGC TTGATCTGAAGGCTGGCCATGAAATCTCAAGGTCAACATTGGTATTCCAGTTCAGATAAAAACTGTAAAGTGAGCTTTCGTGAGAAGCTTCTGATTATTG ATTCAAACCTGGGGGTCCAAGATGTGGAGAACCTCAAGTTTCTCTGCATAGGATTGGTCCCCAACAAGAAGCTGGAGAAGTCCAGCTCAGCCTCAGATGT TTTTGAACATCTCTTGGCAGAGGATCTGCTGAGTGAGGAAGACCCTTTCTTCCTGGCAGAACTCCTCTATATCATACGGCAGAAGAAGCTGCTGCAGCAC CTCAACTGTACCAAAGAGGAAGTGGAGCGACTGCTGCCCACCCGACAAAGGGTTTCTCTGTTTAGAAACCTGCTCTACGAACTGTCAGAAGGCATTGACT CAGAGAACTTAAAGGACATGATCTTCCTTCTGAAAGACTCGCTTCCCAAAACTGAAATGACCTCCCTAAGTTTCCTGGCATTTCTAGAGAAACAAGGTAA AATAGATGAAGATAATCTGACATGCCTGGAGGACCTCTGCAAAACAGTTGTACCTAAACTTTTGAGAAACATAGAGAAATACAAAAGAGAGAAAGCTATC CAGATAGTGACACCTCCTGTAGACAAGGAAGCCGAGTCGTATCAAGGAGAGGAAGAACTAGTTTCCCAAACAGATGTTAAGACATTCTTGGAAGCCTTAC CGCAGGAGTCCTGGCAAAATAAGCATGCAGGTAGTAATGGTAACAGAGCCACAAATGGTGCACCAAGCCTGGTCTCCAGGGGGATGCAAGGAGCATCTGC TAACACTCTAAACTCTGAAACCAGCACAAAGAGGGCAGCTGTGTACAGGATGAATCGGAACCACAGAGGCCTCTGTGTCATTGTCAACAACCACAGCTTT ACCTCCCTGAAGGACAGACAAGGAACCCATAAAGATGCTGAGATCCTGAGTCATGTGTTCCAGTGGCTTGGGTTCACAGTGCATATACACAATAATGTGA CGAAAGTGGAAATGGAGATGGTCCTGCAGAAGCAGAAGTGCAATCCAGCCCATGCCGACGGGGACTGCTTCGTGTTCTGTATTCTGACCCATGGGAGATT TGGAGCTGTCTACTCTTCGGATGAGGCCCTCATTCCCATTCGGGAGATCATGTCTCACTTCACAGCCCTGCAGTGCCCTAGACTGGCTGAAAAACCTAAA CTCTTTTTCATCCAGGCCTGCCAAGGTGAAGAGATACAGCCTTCCGTATCCATCGAAGCAGATGCTCTGAACCCTGAGCAGGCACCCACTTCCCTGCAGG ACAGTATTCCTGCCGAGGCTGACTTCCTACTTGGTCTGGCCACTGTCCCAGGCTATGTATCCTTTCGGCATGTGGAGGAAGGCAGCTGGTATATTCAGTC TCTGTGTAATCATCTGAAGAAATTGGTCCCAAGACATGAAGACATCTTATCCATCCTCACTGCTGTCAACGATGATGTGAGTCGAAGAGTGGACAAACAG GGAACAAAGAAACAGATGCCCCAGCCTGCTTTCACACTAAGGAAAAAACTAGTATTCCCTGTGCCCCTGGATGCACTTTCATTATAGCAGAGAGTTTTTG TTGGTTCTTAGACCTCAAACGAATCATTGGCTATAACCTCCAGCCTCCTGCCCAGCACAGGAATCGGTGGTCTCCACCTGTCATTCTAGAAACAGGAAAC ACCGTGTTTTCTGACACAGTCAATTCTGATTTTCTTTTTCTTTTGCAAGTCTAAATGTTAGAAAACTTTCTTTTTTTTGGAGATAGTCTCATTCTGTCAC CCAGACTGGAGTGCAGGGGGGCAATCACGGCTCACTGTAGTCTCGACCTCCCAGGTTCAAGCGATCCTCCCACCTCAGCCTCCCAAGTAGCTGAGACTAC AGGTGTGTGTCCATGCACAGCTAACTTTTTATTTTTTTTGTGGAGATGGGGTTTCACTATGTTGCCTAAGCTGGTCTCAAACTCCTGGGCTCAAGCGATC CTCCCACCTCAGCTTCTCAAAGTTCTGGGACTACAGGCATGAAATACTGTGCCTGGCCTGGGGACCAGGTGCATTTTAAGGTTCCTTGGTGTTCAAAAAC CACGTTCTTAGCCTAGATTGAGCTTAGATTGCCTCTCTAGACAACTACCCCTTAGTTATAATTCTGTGTCCCCTCTGCATGCCCTTAAACATTGGACAGT GAGGTCACAGTCCACCCACCCTCTCTCTGATCTCCCCCTTCCTAAGACTTCTCTTTTGCACATCTAGTGAGGTGAAAATTTGGTCTATGCCAGGCCCATT TCCTGCTTTTGTGTAAGGAAGGTGCTCACATAGGAAGTTTTTATTTGGTTAGAGACAGGTTTCCCTGTAGGAAGATGATGGCTCATTTACACTCAGCTGC TCTGCAAGCAGAAACTTTACAACCTGATGTCATATTCCATTTTGGACTGGGTGCGGTGACTCATGCCTGTAATCCCAGTACTCTGGGAAGCCAAGGCAGG CAGATCACTTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAATACGGCAAAACCTCATCATTACTAAAAACACAAAAATTAGCCAGGTGTGGCGGCGAGCA CCTGTAATCCCAGCTACTCGGGAGGCTGAGACAGGAGAATCTCTTGAATCCAGGAGGCAGAGGCTGTGGTGAGCCAAGATGACACAACTGCACTCCAGCT TGGGCAACAGGGCGAGACCTTGTTTAAAAAAAAAATTCAATATTGGGGTTGGAACATTTCAGTTGCCATTGACAGAACACCCAATTCAAATTGACTGAAG CAAAGAAGGGAATTTATTGCCTCTTTCACATTGAAACCCAGGAGTGGATAACACTGGCTTCAGGCAAAGCTTGAATCAGGACTCAATCTACAGGCCAGCA CCTTTCTCTTGGCCGGATGTCCTCAGGGCTGGCAGATGCAGTAGACTGCAGTGGACAGTCCCCACCTTGTTACTGCTACTACACTTTGCTCCTCTGGCCC AAGGCATGAGGAGAGAGGCTGTGTCAGAAACTGAAGCTGTTCTCAGGATCACTGGGCTCTTCTTGGCAGAGGGGATGTCTGGCTTGCCTGAAGGGAGTGG CTCTGTAAGGACGCCTTGATGCTTTCTTCATTAAGATTTTGAGCATTTTTACGTACTTGAGCTTTTTTTTTTTTTTTTTTCAATTTCTAGAGGAACTTTT TCTCTGTTAATTCCTGGAACTGTATTTTGAATCCTTAAAGGTGAGCCCTCATAGGGAGATCCAAAGTCCTGTGGTTAACGCCTTCATTTATAGATGAGGC AGCTGAGGCCTGGGGATGTGAACAACCTGCTCACAGTCCTCATTTACTGGATTTGACTTCAGCCAGGTGAACTGGAATGCCTTGGGGCGTGGAAGGGCAT TAGGAGTGTTTCATTTGATATGTGAATGCTCATAAAAAAATGTCAAGGAATGAAGAACAACAACTCTCAGTGGTGCCTGCATTTATAATTATTTATGTGA AAGTCAAATTCATGTACAGTAAATTTGTTATAAGAATATTCACAAGAACACTGTTCTGATATCTCTGATTGTCATGTGGATTTGAATGTAGCTTGACAGA GGGAATGTCTAATCTATATTGACAGGGCAGGAACACCGTCATCTTAGACAAACACCGCCACTTTAAGTTCCAGTTCCCTTTCTAG

CASP10.b.f.23 (forward primer)
CASP10.u.r.15 (reverse primer)
Multiple exon skipping

Frame 0

KEMEIQRKA*STLWLPRVRF*EAFALPGETPSS TVRKL*ISL*ETLFVKVILTLEKGREKGR*AVMT SAGN*YQATQS*RFSFHLNNQQVLKSLPKQMGA SLDLGAHRGFYFL*NFVFRQFP*EPFTSRRLVE LDLKAGHEISRSTLVFQFR*KL*SELS*EASDY* FKPGGPRCGEPQVSLHRIGPQQEAGEVQLSLRC F*TSLGRGSAE*GRPFLPGRTPLYHTAEEAAAA PQLYQRGSGATAAHPTKGFSV*KPALRTVRRH*L RELKGHDLPSERLASQN*NDLPKFPGISRETR* NR*R*SDMPGGPLQNSCT*TFEKHREIQKRESY PDSDTSCRQGSRVVSRRGRTSFPNRC*DILGSLT AGVLAK*ACR**W*QSHKWCTKPGLQGDARSIC *HSKL*NQHKEGSCVQDESEPQRPLCHCQQPQL YLPEGQTRNP*RC*DPESCVPVAWVHSAYTQ*CD ESGNGDGPAEAEVQSSPCRRGLLRVLYSDPWEI WSCLLFG*GPHSHSGDHVSLHSPAVP*TG*KT* TLFHPGLPR*RDTAFRIHRSRCSEP*AGTHFPAG QYSCRG*LPTWSGHCPRLCILSACGGRQLVYSV SV*SSEEIGPKT*RHLIHPHCCQR*CESKSGQT GNKETDAPACFHTKEKTSIPCAPGCTFIIAESFC WFLDLKRIIGYNLQPPAQHRNRWSPPVILETGN TVFSDTVNSDFLFLLQV*MLENFLFFGDSLILS PRLECRGAITAHCSLDLPGSSDPPTSASQVAETT GVCPCTANFLFFLWRWGFTMLPKLVSNSWAQAI LPPQLLKVLGLQA*NTVPGLGTRCILRFLGVQK PRS*PRLSLDCLSRQLPLSYNSVSPLHALKHWTV RSQSTHPLSDLPLPKTSLLHI**GENLVYARPI SCFCVRKVLT*EVFIWLETGFPVGR*WLIYTQL LCKQKLYNLMSYSILDWVR*LMPVIPVLWEAKAG RSLEVRSSRPAWPIRQNLIITKNTKISQVWRRA PVIPATREAETGESLESRRQRLW*AKMTQLHSS LGNRARPCLKKKFNIGVGTFQLPLTEHPIQID*S KEGNLLPLSH*NPGVDNTGFRQSLNQDSIYRPA PFSWPDVLRAGRCSRLQWTVPTLLLLLHFAPLA QGMRREAVSETEAVLRITGLFLAEGMSGLPEGSG SVRTP*CFLH*DFEHFYVLELFFFFFSISRGTF SLLIPGTVF*ILKGEPS*GDPKSCG*RLHL*MR QLRPGDVNNLLTVLIYWI*LQPGELECLGAWKGI RSVSFDM*MLIKKCQGMKNNNSQWCLHL*LFM* KSNSCTVNLL*EYSQEHCSDISDCHVDLNVA*Q RECLIYIDRAGTPSS*TNTATLSSSSLS

Frame 1

RKWRSKGKPEALCGFHGFVSRKLLLYLGKPQAL Q*ESCKLAFRRRCLSKLS*PWKRGGKKADKQ** HQQETSIRLPSPEDSVFT*TTSKS*SLFPSKWEL LWTLEHTEDSTFFKTLFSGNFPENRLLPEDWWS LI*RLAMKSQGQHWYSSSDKNCKVSFREKLLII DSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDV FEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQH LNCTKEEVERLLPTRQRVSLFRNLLYELSEGID SENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGK IDEDNLTCLEDLCKTVVPKLLRNIEKYKREKAI QIVTPPVDKEAESYQGEEELVSQTDVKTFLEAL PQESWQNKHAGSNGNRATNGAPSLVSRGMQGASA NTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSF TSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNV TKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRF GAVYSSDEALIPIREIMSHFTALQCPRLAEKPK LFFIQACQGEEIQPSVSIEADALNPEQAPTSLQ DSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQS LCNHLKKLVPRHEDILSILTAVNDDVSRRVDKQ GTKKQMPQPAFTLRKKLVFPVPLDALSL*QRVF VGS*TSNESLAITSSLLPSTGIGGLHLSF*KQET PCFLTQSILIFFFFCKSKC*KTFFFLEIVSFCH PDWSAGGQSRLTVVSTSQVQAILPPQPPK*LRL QVCVHAQLTFYFFCGDGVSLCCLSWSQTPGLKRS SHLSFSKFWDYRHEILCLAWGPGAF*GSLVFKN HVLSLD*A*IASLDNYPLVIILCPLCMPLNIGQ *GHSPPTLSLISPFLRLLFCTSSEVKIWSMPGPF PAFV*GRCSHRKFLFG*RQVSL*EDDGSFTLSC SASRNFTT*CHIPFWTGCGDSCL*SQYSGKPRQ ADHLRSGVRDQPGQYGKTSSLLKTQKLARCGGEH L*SQLLGRLRQENLLNPGGRGCGEPR*HNCTPA WATGRDLV*KKNSILGLEHFSCH*QNTQFKLTE AKKGIYCLFHIETQEWITLASGKA*IRTQSTGQH LSLGRMSSGLADAVDCSGQSPPCYCYYTLLLWP KA*GERLCQKLKLFSGSLGSSWQRGCLACLKGV AL*GRLDAFFIKILSIFTYLSFFFFFFQFLEELF LC*FLELYFESLKVSPHREIQSPVVNAFIYR*G S*GLGM*TTCSQSSFTGFDFSQVNWNALGRGRA LGVFHLICECS*KNVKE*RTTTLSGACIYNYLCE SQIHVQ*ICYKNIHKNTVLISLIVMWI*M*LDR GNV*SILTGQEHRHLRQTPPL*VPVPFL

Frame 2

GNGDPKESLKHFVASTGSFLGSFCFTWGNPKLY SEKVVN*PLGDAVCQSYLNPGKGEGKRQISSDD ISRKLVSGYPVLKIQFSLKQPASLEVSSQANGS FFGPWSTQRILLSLKLCFQAISLRTVYFQKIGGA *SEGWP*NLKVNIGIPVQIKTVK*AFVRSF*LL IQTWGSKMWRTSSFSA*DWSPTRSWRSPAQPQM FLNISWQRIC*VRKTLSSWQNSSISYGRRSCCST STVPKRKWSDCCPPDKGFLCLETCSTNCQKALT QRT*RT*SSF*KTRFPKLK*PP*VSWHF*RNKV K*MKII*HAWRTSAKQLYLNF*ET*RNTKERKLS R**HLL*TRKPSRIKERKN*FPKQMLRHSWKPY RRSPGKISMQVVMVTEPQMVHQAWSPGGCKEHL LTL*TLKPAQRGQLCTG*IGTTEASVSLSTTTAL PP*RTDKEPIKMLRS*VMCSSGLGSQCIYTIM* RKWKWRWSCRSRSAIQPMPTGTASCSVF*PMGD LELSTLRMRPSFPFGRSCLTSQPCSALDWLKNLN SFSSRPAKVKRYSLPYPSKQML*TLSRHPLPCR TVFLPRLTSYLVWPLSQAMYPFGMWRKAAGIFS LCVII*RNWSQDMKTSYPSSLLSTMM*VEEWTNR EQRNRCPSLLSH*GKN*YSLCPWMHFHYSREFL LVLRPQTNHWL*PPASCPAQESVVSTCHSRNRK HRVF*HSQF*FSFSFASLNVRKLSFFWR*SHSVT QTGVQGGNHGSL*SRPPRFKRSSHLSLPSS*DY RCVSMHS*LFIFFVEMGFHYVA*AGLKLLGSSD PPTSASQSSGTTGMKYCAWPGDQVHFKVPWCSKT TFLA*IELRLPL*TTTP*L*FCVPSACP*TLDS EVTVHPPSL*SPPS*DFSFAHLVR*KFGLCQAH FLLLCKEGAHIGSFYLVRDRFPCRKMMAHLHSAA LQAETLQPDVIFHFGLGAVTHACNPSTLGSQGR QIT*GQEFETSLANTAKPHHY*KHKN*PGVAAS TCNPSYSGG*DRRIS*IQEAEAVVSQDDTTALQL GQQGETLFKKKIQYWGWNISVAIDRTPNSN*LK QRREFIASFTLKPRSG*HWLQAKLESGLNLQAS TFLLAGCPQGWQMQ*TAVDSPHLVTATTLCSSGP RHEERGCVRN*SCSQDHWALLGRGDVWLA*REW LCKDALMLSSLRF*AFLRT*AFFFFFFNF*RNF FSVNSWNCILNP*R*ALIGRSKVLWLTPSFIDEA AEAWGCEQPAHSPHLLDLTSAR*TGMPWGVEGH *ECFI*YVNAHKKMSRNEEQQLSVVPAFIIIYV KVKFMYSKFVIRIFTRTLF*YL*LSCGFECSLTE GMSNLY*QGRNTVILDKHRHFKFQFPF*