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Sequences

Sequence CASP10.eAug05

CASP10.b.f.23 (forward primer)
CASP10.u.r.15 (reverse primer)
Single exon skipping

Frame 0

Frame 1

Frame 2

Sequence CASP10.dAug05

AAGGAAATGGAGATCCAAAGGAAAGCCTGAAGCACTTTGTGGCTTCCACGGGTTCGTTTCTAGGAAGCTTTTGCTTTACCTGGGGAAACCCCAAGCTCTA CAGTGAGAAAGTTGTAAATTAGCCTTTAGGAGACGCTGTTTGTCAAAGTTATCTTAACCCTGGAAAAGGGGAGGGAAAAAGGCAGATAAGCAGTGATGAC ATCAGCAGGAAACTAGTATCAGGCTACCCAGTCCTGAAGATTCAGTTTTCACTTAAACAACCAGCAAGTCTTGAAGTCTCTTCCCAAGCAAATGGGAGCT TCTTTGGACCTTGGAGCACACAGAGGATTCTACTTTCTTTAAAACTTTGTTTTCAGGCAATTTCCCTGAGAACCGTTTACTTCCAGAAGATTGGTGGAGC TTGATCTGAAGGCTGGCCATGAAATCTCAAGGTCAACATTGGTATTCCAGTTCAGATAAAAACTGTAAAGTGAGCTTTCGTGAGAAGCTTCTGATTATTG ATTCAAACCTGGGGGTCCAAGATGTGGAGAACCTCAAGTTTCTCTGCATAGGATTGGTCCCCAACAAGAAGCTGGAGAAGTCCAGCTCAGCCTCAGATGT TTTTGAACATCTCTTGGCAGAGGATCTGCTGAGTGAGGAAGACCCTTTCTTCCTGGCAGAACTCCTCTATATCATACGGCAGAAGAAGCTGCTGCAGCAC CTCAACTGTACCAAAGAGGAAGTGGAGCGACTGCTGCCCACCCGACAAAGGGTTTCTCTGTTTAGAAACCTGCTCTACGAACTGTCAGAAGGCATTGACT CAGAGAACTTAAAGGACATGATCTTCCTTCTGAAAGACTCGCTTCCCAAAACTGAAATGACCTCCCTAAGTTTCCTGGCATTTCTAGAGAAACAAGGTAA AATAGATGAAGATAATCTGACATGCCTGGAGGACCTCTGCAAAACAGTTGTACCTAAACTTTTGAGAAACATAGAGAAATACAAAAGAGAGAAAGCTATC CAGATAGTGACACCTCCTGTAGACAAGGAAGCCGAGTCGTATCAAGGAGAGGAAGAACTAGTTTCCCAAACAGATGTTAAGACATTCTTGGAAGCCTTAC CGAGGGCAGCTGTGTACAGGATGAATCGGAACCACAGAGGCCTCTGTGTCATTGTCAACAACCACAGCTTTACCTCCCTGAAGGACAGACAAGGAACCCA TAAAGATGCTGAGATCCTGAGTCATGTGTTCCAGTGGCTTGGGTTCACAGTGCATATACACAATAATGTGACGAAAGTGGAAATGGAGATGGTCCTGCAG AAGCAGAAGTGCAATCCAGCCCATGCCGACGGGGACTGCTTCGTGTTCTGTATTCTGACCCATGGGAGATTTGGAGCTGTCTACTCTTCGGATGAGGCCC TCATTCCCATTCGGGAGATCATGTCTCACTTCACAGCCCTGCAGTGCCCTAGACTGGCTGAAAAACCTAAACTCTTTTTCATCCAGGCCTGCCAAGGTGA AGAGATACAGCCTTCCGTATCCATCGAAGCAGATGCTCTGAACCCTGAGCAGGCACCCACTTCCCTGCAGGACAGTATTCCTGCCGAGGCTGACTTCCTA CTTGGTCTGGCCACTGTCCCAGGCTATGTATCCTTTCGGCATGTGGAGGAAGGCAGCTGGTATATTCAGTCTCTGTGTAATCATCTGAAGAAATTGGTCC CAAGACATGAAGACATCTTATCCATCCTCACTGCTGTCAACGATGATGTGAGTCGAAGAGTGGACAAACAGGGAACAAAGAAACAGATGCCCCAGCCTGC TTTCACACTAAGGAAAAAACTAGTATTCCCTGTGCCCCTGGATGCACTTTCATTATAGCAGAGAGTTTTTGTTGGTTCTTAGACCTCAAACGAATCATTG GCTATAACCTCCAGCCTCCTGCCCAGCACAGGAATCGGTGGTCTCCACCTGTCATTCTAGAAACAGGAAACACCGTGTTTTCTGACACAGTCAATTCTGA TTTTCTTTTTCTTTTGCAAGTCTAAATGTTAGAAAACTTTCTTTTTTTTGGAGATAGTCTCATTCTGTCACCCAGACTGGAGTGCAGGGGGGCAATCACG GCTCACTGTAGTCTCGACCTCCCAGGTTCAAGCGATCCTCCCACCTCAGCCTCCCAAGTAGCTGAGACTACAGGTGTGTGTCCATGCACAGCTAACTTTT TATTTTTTTTGTGGAGATGGGGTTTCACTATGTTGCCTAAGCTGGTCTCAAACTCCTGGGCTCAAGCGATCCTCCCACCTCAGCTTCTCAAAGTTCTGGG ACTACAGGCATGAAATACTGTGCCTGGCCTGGGGACCAGGTGCATTTTAAGGTTCCTTGGTGTTCAAAAACCACGTTCTTAGCCTAGATTGAGCTTAGAT TGCCTCTCTAGACAACTACCCCTTAGTTATAATTCTGTGTCCCCTCTGCATGCCCTTAAACATTGGACAGTGAGGTCACAGTCCACCCACCCTCTCTCTG ATCTCCCCCTTCCTAAGACTTCTCTTTTGCACATCTAGTGAGGTGAAAATTTGGTCTATGCCAGGCCCATTTCCTGCTTTTGTGTAAGGAAGGTGCTCAC ATAGGAAGTTTTTATTTGGTTAGAGACAGGTTTCCCTGTAGGAAGATGATGGCTCATTTACACTCAGCTGCTCTGCAAGCAGAAACTTTACAACCTGATG TCATATTCCATTTTGGACTGGGTGCGGTGACTCATGCCTGTAATCCCAGTACTCTGGGAAGCCAAGGCAGGCAGATCACTTGAGGTCAGGAGTTCGAGAC CAGCCTGGCCAATACGGCAAAACCTCATCATTACTAAAAACACAAAAATTAGCCAGGTGTGGCGGCGAGCACCTGTAATCCCAGCTACTCGGGAGGCTGA GACAGGAGAATCTCTTGAATCCAGGAGGCAGAGGCTGTGGTGAGCCAAGATGACACAACTGCACTCCAGCTTGGGCAACAGGGCGAGACCTTGTTTAAAA AAAAAATTCAATATTGGGGTTGGAACATTTCAGTTGCCATTGACAGAACACCCAATTCAAATTGACTGAAGCAAAGAAGGGAATTTATTGCCTCTTTCAC ATTGAAACCCAGGAGTGGATAACACTGGCTTCAGGCAAAGCTTGAATCAGGACTCAATCTACAGGCCAGCACCTTTCTCTTGGCCGGATGTCCTCAGGGC TGGCAGATGCAGTAGACTGCAGTGGACAGTCCCCACCTTGTTACTGCTACTACACTTTGCTCCTCTGGCCCAAGGCATGAGGAGAGAGGCTGTGTCAGAA ACTGAAGCTGTTCTCAGGATCACTGGGCTCTTCTTGGCAGAGGGGATGTCTGGCTTGCCTGAAGGGAGTGGCTCTGTAAGGACGCCTTGATGCTTTCTTC ATTAAGATTTTGAGCATTTTTACGTACTTGAGCTTTTTTTTTTTTTTTTTTCAATTTCTAGAGGAACTTTTTCTCTGTTAATTCCTGGAACTGTATTTTG AATCCTTAAAGGTGAGCCCTCATAGGGAGATCCAAAGTCCTGTGGTTAACGCCTTCATTTATAGATGAGGCAGCTGAGGCCTGGGGATGTGAACAACCTG CTCACAGTCCTCATTTACTGGATTTGACTTCAGCCAGGTGAACTGGAATGCCTTGGGGCGTGGAAGGGCATTAGGAGTGTTTCATTTGATATGTGAATGC TCATAAAAAAATGTCAAGGAATGAAGAACAACAACTCTCAGTGGTGCCTGCATTTATAATTATTTATGTGAAAGTCAAATTCATGTACAGTAAATTTGTT ATAAGAATATTCACAAGAACACTGTTCTGATATCTCTGATTGTCATGTGGATTTGAATGTAGCTTGACAGAGGGAATGTCTAATCTATATTGACAGGGCA GGAACACCGTCATCTTAGACAAACACCGCCACTTTAAGTTCCAGTTCCCTTTCTAG

CASP10.b.f.23 (forward primer)
CASP10.u.r.15 (reverse primer)
Single exon skipping

Frame 0

KEMEIQRKA*STLWLPRVRF*EAFALPGETPSS TVRKL*ISL*ETLFVKVILTLEKGREKGR*AVMT SAGN*YQATQS*RFSFHLNNQQVLKSLPKQMGA SLDLGAHRGFYFL*NFVFRQFP*EPFTSRRLVE LDLKAGHEISRSTLVFQFR*KL*SELS*EASDY* FKPGGPRCGEPQVSLHRIGPQQEAGEVQLSLRC F*TSLGRGSAE*GRPFLPGRTPLYHTAEEAAAA PQLYQRGSGATAAHPTKGFSV*KPALRTVRRH*L RELKGHDLPSERLASQN*NDLPKFPGISRETR* NR*R*SDMPGGPLQNSCT*TFEKHREIQKRESY PDSDTSCRQGSRVVSRRGRTSFPNRC*DILGSLT EGSCVQDESEPQRPLCHCQQPQLYLPEGQTRNP *RC*DPESCVPVAWVHSAYTQ*CDESGNGDGPA EAEVQSSPCRRGLLRVLYSDPWEIWSCLLFG*GP HSHSGDHVSLHSPAVP*TG*KT*TLFHPGLPR* RDTAFRIHRSRCSEP*AGTHFPAGQYSCRG*LP TWSGHCPRLCILSACGGRQLVYSVSV*SSEEIGP KT*RHLIHPHCCQR*CESKSGQTGNKETDAPAC FHTKEKTSIPCAPGCTFIIAESFCWFLDLKRII GYNLQPPAQHRNRWSPPVILETGNTVFSDTVNSD FLFLLQV*MLENFLFFGDSLILSPRLECRGAIT AHCSLDLPGSSDPPTSASQVAETTGVCPCTANF LFFLWRWGFTMLPKLVSNSWAQAILPPQLLKVLG LQA*NTVPGLGTRCILRFLGVQKPRS*PRLSLD CLSRQLPLSYNSVSPLHALKHWTVRSQSTHPLS DLPLPKTSLLHI**GENLVYARPISCFCVRKVLT *EVFIWLETGFPVGR*WLIYTQLLCKQKLYNLM SYSILDWVR*LMPVIPVLWEAKAGRSLEVRSSR PAWPIRQNLIITKNTKISQVWRRAPVIPATREAE TGESLESRRQRLW*AKMTQLHSSLGNRARPCLK KKFNIGVGTFQLPLTEHPIQID*SKEGNLLPLS H*NPGVDNTGFRQSLNQDSIYRPAPFSWPDVLRA GRCSRLQWTVPTLLLLLHFAPLAQGMRREAVSE TEAVLRITGLFLAEGMSGLPEGSGSVRTP*CFL H*DFEHFYVLELFFFFFSISRGTFSLLIPGTVF* ILKGEPS*GDPKSCG*RLHL*MRQLRPGDVNNL LTVLIYWI*LQPGELECLGAWKGIRSVSFDM*M LIKKCQGMKNNNSQWCLHL*LFM*KSNSCTVNLL *EYSQEHCSDISDCHVDLNVA*QRECLIYIDRA GTPSS*TNTATLSSSSLS

Frame 1

RKWRSKGKPEALCGFHGFVSRKLLLYLGKPQAL Q*ESCKLAFRRRCLSKLS*PWKRGGKKADKQ** HQQETSIRLPSPEDSVFT*TTSKS*SLFPSKWEL LWTLEHTEDSTFFKTLFSGNFPENRLLPEDWWS LI*RLAMKSQGQHWYSSSDKNCKVSFREKLLII DSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDV FEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQH LNCTKEEVERLLPTRQRVSLFRNLLYELSEGID SENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGK IDEDNLTCLEDLCKTVVPKLLRNIEKYKREKAI QIVTPPVDKEAESYQGEEELVSQTDVKTFLEAL PRAAVYRMNRNHRGLCVIVNNHSFTSLKDRQGTH KDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQ KQKCNPAHADGDCFVFCILTHGRFGAVYSSDEA LIPIREIMSHFTALQCPRLAEKPKLFFIQACQGE EIQPSVSIEADALNPEQAPTSLQDSIPAEADFL LGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLV PRHEDILSILTAVNDDVSRRVDKQGTKKQMPQPA FTLRKKLVFPVPLDALSL*QRVFVGS*TSNESL AITSSLLPSTGIGGLHLSF*KQETPCFLTQSIL IFFFFCKSKC*KTFFFLEIVSFCHPDWSAGGQSR LTVVSTSQVQAILPPQPPK*LRLQVCVHAQLTF YFFCGDGVSLCCLSWSQTPGLKRSSHLSFSKFW DYRHEILCLAWGPGAF*GSLVFKNHVLSLD*A*I ASLDNYPLVIILCPLCMPLNIGQ*GHSPPTLSL ISPFLRLLFCTSSEVKIWSMPGPFPAFV*GRCS HRKFLFG*RQVSL*EDDGSFTLSCSASRNFTT*C HIPFWTGCGDSCL*SQYSGKPRQADHLRSGVRD QPGQYGKTSSLLKTQKLARCGGEHL*SQLLGRL RQENLLNPGGRGCGEPR*HNCTPAWATGRDLV*K KNSILGLEHFSCH*QNTQFKLTEAKKGIYCLFH IETQEWITLASGKA*IRTQSTGQHLSLGRMSSG LADAVDCSGQSPPCYCYYTLLLWPKA*GERLCQK LKLFSGSLGSSWQRGCLACLKGVAL*GRLDAFF IKILSIFTYLSFFFFFFQFLEELFLC*FLELYF ESLKVSPHREIQSPVVNAFIYR*GS*GLGM*TTC SQSSFTGFDFSQVNWNALGRGRALGVFHLICEC S*KNVKE*RTTTLSGACIYNYLCESQIHVQ*IC YKNIHKNTVLISLIVMWI*M*LDRGNV*SILTGQ EHRHLRQTPPL*VPVPFL

Frame 2

GNGDPKESLKHFVASTGSFLGSFCFTWGNPKLY SEKVVN*PLGDAVCQSYLNPGKGEGKRQISSDD ISRKLVSGYPVLKIQFSLKQPASLEVSSQANGS FFGPWSTQRILLSLKLCFQAISLRTVYFQKIGGA *SEGWP*NLKVNIGIPVQIKTVK*AFVRSF*LL IQTWGSKMWRTSSFSA*DWSPTRSWRSPAQPQM FLNISWQRIC*VRKTLSSWQNSSISYGRRSCCST STVPKRKWSDCCPPDKGFLCLETCSTNCQKALT QRT*RT*SSF*KTRFPKLK*PP*VSWHF*RNKV K*MKII*HAWRTSAKQLYLNF*ET*RNTKERKLS R**HLL*TRKPSRIKERKN*FPKQMLRHSWKPY RGQLCTG*IGTTEASVSLSTTTALPP*RTDKEP IKMLRS*VMCSSGLGSQCIYTIM*RKWKWRWSCR SRSAIQPMPTGTASCSVF*PMGDLELSTLRMRP SFPFGRSCLTSQPCSALDWLKNLNSFSSRPAKV KRYSLPYPSKQML*TLSRHPLPCRTVFLPRLTSY LVWPLSQAMYPFGMWRKAAGIFSLCVII*RNWS QDMKTSYPSSLLSTMM*VEEWTNREQRNRCPSL LSH*GKN*YSLCPWMHFHYSREFLLVLRPQTNHW L*PPASCPAQESVVSTCHSRNRKHRVF*HSQF* FSFSFASLNVRKLSFFWR*SHSVTQTGVQGGNH GSL*SRPPRFKRSSHLSLPSS*DYRCVSMHS*LF IFFVEMGFHYVA*AGLKLLGSSDPPTSASQSSG TTGMKYCAWPGDQVHFKVPWCSKTTFLA*IELR LPL*TTTP*L*FCVPSACP*TLDSEVTVHPPSL* SPPS*DFSFAHLVR*KFGLCQAHFLLLCKEGAH IGSFYLVRDRFPCRKMMAHLHSAALQAETLQPD VIFHFGLGAVTHACNPSTLGSQGRQIT*GQEFET SLANTAKPHHY*KHKN*PGVAASTCNPSYSGG* DRRIS*IQEAEAVVSQDDTTALQLGQQGETLFK KKIQYWGWNISVAIDRTPNSN*LKQRREFIASFT LKPRSG*HWLQAKLESGLNLQASTFLLAGCPQG WQMQ*TAVDSPHLVTATTLCSSGPRHEERGCVR N*SCSQDHWALLGRGDVWLA*REWLCKDALMLSS LRF*AFLRT*AFFFFFFNF*RNFFSVNSWNCIL NP*R*ALIGRSKVLWLTPSFIDEAAEAWGCEQP AHSPHLLDLTSAR*TGMPWGVEGH*ECFI*YVNA HKKMSRNEEQQLSVVPAFIIIYVKVKFMYSKFV IRIFTRTLF*YL*LSCGFECSLTEGMSNLY*QG RNTVILDKHRHFKFQFPF*

Sequence CASP10.gAug05

AAGGAAATGGAGATCCAAAGGAAAGCCTGAAGCACTTTGTGGCTTCCACGGGTTCGTTTCTAGGAAGCTTTTGCTTTACCTGGGGAAACCCCAAGCTCTA CAGTGAGAAAGTTGTAAATTAGCCTTTAGGAGACGCTGTTTGTCAAAGTTATCTTAACCCTGGAAAAGGGGAGGGAAAAAGGCAGATAAGCAGTGATGAC ATCAGCAGGAAACTAGTATCAGGCTACCCAGTCCTGAAGATTCAGTTTTCACTTAAACAACCAGCAAGTCTTGAAGTCTCTTCCCAAGCAAATGGGAGCT TCTTTGGACCTTGGAGCACACAGAGGATTCTACTTTCTTTAAAACTTTGTTTTCAGGCAATTTCCCTGAGAACCGTTTACTTCCAGAAGATTGGTGGAGC TTGATCTGAAGGCTGGCCATGAAATCTCAAGGTCAACATTGGTATTCCAGTTCAGATAAAAACTGTAAAGTGAGCTTTCGTGAGAAGCTTCTGATTATTG ATTCAAACCTGGGGGTCCAAGATGTGGAGAACCTCAAGTTTCTCTGCATAGGATTGGTCCCCAACAAGAAGCTGGAGAAGTCCAGCTCAGCCTCAGATGT TTTTGAACATCTCTTGGCAGAGGATCTGCTGAGTGAGGAAGACCCTTTCTTCCTGGCAGAACTCCTCTATATCATACGGCAGAAGAAGCTGCTGCAGCAC CTCAACTGTACCAAAGAGGAAGTGGAGCGACTGCTGCCCACCCGACAAAGGGTTTCTCTGTTTAGAAACCTGCTCTACGAACTGTCAGAAGGCATTGACT CAGAGAACTTAAAGGACATGATCTTCCTTCTGAAAGACTCGCTTCCCAAAACTGAAATGACCTCCCTAAGTTTCCTGGCATTTCTAGAGAAACAAGGTAA AATAGATGAAGATAATCTGACATGCCTGGAGGACCTCTGCAAAACAGTTGTACCTAAACTTTTGAGAAACATAGAGAAATACAAAAGAGAGAAAGCTATC CAGATAGTGACACCTCCTGTAGACAAGGAAGCCGAGTCGTATCAAGGAGAGGAAGAACTAGTTTCCCAAACAGATGTTAAGACATTCTTGGAAGCCTTAC CGCAGGAGTCCTGGCAAAATAAGCATGCAGGTAGTAATGAGGGCAGCTGTGTACAGGATGAATCGGAACCACAGAGGCCTCTGTGTCATTGTCAACAACC ACAGCTTTACCTCCCTGAAGGACAGACAAGGAACCCATAAAGATGCTGAGATCCTGAGTCATGTGTTCCAGTGGCTTGGGTTCACAGTGCATATACACAA TAATGTGACGAAAGTGGAAATGGAGATGGTCCTGCAGAAGCAGAAGTGCAATCCAGCCCATGCCGACGGGGACTGCTTCGTGTTCTGTATTCTGACCCAT GGGAGATTTGGAGCTGTCTACTCTTCGGATGAGGCCCTCATTCCCATTCGGGAGATCATGTCTCACTTCACAGCCCTGCAGTGCCCTAGACTGGCTGAAA AACCTAAACTCTTTTTCATCCAGGCCTGCCAAGGTGAAGAGATACAGCCTTCCGTATCCATCGAAGCAGATGCTCTGAACCCTGAGCAGGCACCCACTTC CCTGCAGGACAGTATTCCTGCCGAGGCTGACTTCCTACTTGGTCTGGCCACTGTCCCAGGCTATGTATCCTTTCGGCATGTGGAGGAAGGCAGCTGGTAT ATTCAGTCTCTGTGTAATCATCTGAAGAAATTGGTCCCAAGACATGAAGACATCTTATCCATCCTCACTGCTGTCAACGATGATGTGAGTCGAAGAGTGG ACAAACAGGGAACAAAGAAACAGATGCCCCAGCCTGCTTTCACACTAAGGAAAAAACTAGTATTCCCTGTGCCCCTGGATGCACTTTCATTATAGCAGAG AGTTTTTGTTGGTTCTTAGACCTCAAACGAATCATTGGCTATAACCTCCAGCCTCCTGCCCAGCACAGGAATCGGTGGTCTCCACCTGTCATTCTAGAAA CAGGAAACACCGTGTTTTCTGACACAGTCAATTCTGATTTTCTTTTTCTTTTGCAAGTCTAAATGTTAGAAAACTTTCTTTTTTTTGGAGATAGTCTCAT TCTGTCACCCAGACTGGAGTGCAGGGGGGCAATCACGGCTCACTGTAGTCTCGACCTCCCAGGTTCAAGCGATCCTCCCACCTCAGCCTCCCAAGTAGCT GAGACTACAGGTGTGTGTCCATGCACAGCTAACTTTTTATTTTTTTTGTGGAGATGGGGTTTCACTATGTTGCCTAAGCTGGTCTCAAACTCCTGGGCTC AAGCGATCCTCCCACCTCAGCTTCTCAAAGTTCTGGGACTACAGGCATGAAATACTGTGCCTGGCCTGGGGACCAGGTGCATTTTAAGGTTCCTTGGTGT TCAAAAACCACGTTCTTAGCCTAGATTGAGCTTAGATTGCCTCTCTAGACAACTACCCCTTAGTTATAATTCTGTGTCCCCTCTGCATGCCCTTAAACAT TGGACAGTGAGGTCACAGTCCACCCACCCTCTCTCTGATCTCCCCCTTCCTAAGACTTCTCTTTTGCACATCTAGTGAGGTGAAAATTTGGTCTATGCCA GGCCCATTTCCTGCTTTTGTGTAAGGAAGGTGCTCACATAGGAAGTTTTTATTTGGTTAGAGACAGGTTTCCCTGTAGGAAGATGATGGCTCATTTACAC TCAGCTGCTCTGCAAGCAGAAACTTTACAACCTGATGTCATATTCCATTTTGGACTGGGTGCGGTGACTCATGCCTGTAATCCCAGTACTCTGGGAAGCC AAGGCAGGCAGATCACTTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAATACGGCAAAACCTCATCATTACTAAAAACACAAAAATTAGCCAGGTGTGGC GGCGAGCACCTGTAATCCCAGCTACTCGGGAGGCTGAGACAGGAGAATCTCTTGAATCCAGGAGGCAGAGGCTGTGGTGAGCCAAGATGACACAACTGCA CTCCAGCTTGGGCAACAGGGCGAGACCTTGTTTAAAAAAAAAATTCAATATTGGGGTTGGAACATTTCAGTTGCCATTGACAGAACACCCAATTCAAATT GACTGAAGCAAAGAAGGGAATTTATTGCCTCTTTCACATTGAAACCCAGGAGTGGATAACACTGGCTTCAGGCAAAGCTTGAATCAGGACTCAATCTACA GGCCAGCACCTTTCTCTTGGCCGGATGTCCTCAGGGCTGGCAGATGCAGTAGACTGCAGTGGACAGTCCCCACCTTGTTACTGCTACTACACTTTGCTCC TCTGGCCCAAGGCATGAGGAGAGAGGCTGTGTCAGAAACTGAAGCTGTTCTCAGGATCACTGGGCTCTTCTTGGCAGAGGGGATGTCTGGCTTGCCTGAA GGGAGTGGCTCTGTAAGGACGCCTTGATGCTTTCTTCATTAAGATTTTGAGCATTTTTACGTACTTGAGCTTTTTTTTTTTTTTTTTTCAATTTCTAGAG GAACTTTTTCTCTGTTAATTCCTGGAACTGTATTTTGAATCCTTAAAGGTGAGCCCTCATAGGGAGATCCAAAGTCCTGTGGTTAACGCCTTCATTTATA GATGAGGCAGCTGAGGCCTGGGGATGTGAACAACCTGCTCACAGTCCTCATTTACTGGATTTGACTTCAGCCAGGTGAACTGGAATGCCTTGGGGCGTGG AAGGGCATTAGGAGTGTTTCATTTGATATGTGAATGCTCATAAAAAAATGTCAAGGAATGAAGAACAACAACTCTCAGTGGTGCCTGCATTTATAATTAT TTATGTGAAAGTCAAATTCATGTACAGTAAATTTGTTATAAGAATATTCACAAGAACACTGTTCTGATATCTCTGATTGTCATGTGGATTTGAATGTAGC TTGACAGAGGGAATGTCTAATCTATATTGACAGGGCAGGAACACCGTCATCTTAGACAAACACCGCCACTTTAAGTTCCAGTTCCCTTTCTAG

CASP10.b.f.23 (forward primer)
CASP10.u.r.15 (reverse primer)
Single exon skipping

Frame 0

KEMEIQRKA*STLWLPRVRF*EAFALPGETPSS TVRKL*ISL*ETLFVKVILTLEKGREKGR*AVMT SAGN*YQATQS*RFSFHLNNQQVLKSLPKQMGA SLDLGAHRGFYFL*NFVFRQFP*EPFTSRRLVE LDLKAGHEISRSTLVFQFR*KL*SELS*EASDY* FKPGGPRCGEPQVSLHRIGPQQEAGEVQLSLRC F*TSLGRGSAE*GRPFLPGRTPLYHTAEEAAAA PQLYQRGSGATAAHPTKGFSV*KPALRTVRRH*L RELKGHDLPSERLASQN*NDLPKFPGISRETR* NR*R*SDMPGGPLQNSCT*TFEKHREIQKRESY PDSDTSCRQGSRVVSRRGRTSFPNRC*DILGSLT AGVLAK*ACR***GQLCTG*IGTTEASVSLSTT TALPP*RTDKEPIKMLRS*VMCSSGLGSQCIYT IM*RKWKWRWSCRSRSAIQPMPTGTASCSVF*PM GDLELSTLRMRPSFPFGRSCLTSQPCSALDWLK NLNSFSSRPAKVKRYSLPYPSKQML*TLSRHPL PCRTVFLPRLTSYLVWPLSQAMYPFGMWRKAAGI FSLCVII*RNWSQDMKTSYPSSLLSTMM*VEEW TNREQRNRCPSLLSH*GKN*YSLCPWMHFHYSR EFLLVLRPQTNHWL*PPASCPAQESVVSTCHSRN RKHRVF*HSQF*FSFSFASLNVRKLSFFWR*SH SVTQTGVQGGNHGSL*SRPPRFKRSSHLSLPSS *DYRCVSMHS*LFIFFVEMGFHYVA*AGLKLLGS SDPPTSASQSSGTTGMKYCAWPGDQVHFKVPWC SKTTFLA*IELRLPL*TTTP*L*FCVPSACP*T LDSEVTVHPPSL*SPPS*DFSFAHLVR*KFGLCQ AHFLLLCKEGAHIGSFYLVRDRFPCRKMMAHLH SAALQAETLQPDVIFHFGLGAVTHACNPSTLGS QGRQIT*GQEFETSLANTAKPHHY*KHKN*PGVA ASTCNPSYSGG*DRRIS*IQEAEAVVSQDDTTA LQLGQQGETLFKKKIQYWGWNISVAIDRTPNSN *LKQRREFIASFTLKPRSG*HWLQAKLESGLNLQ ASTFLLAGCPQGWQMQ*TAVDSPHLVTATTLCS SGPRHEERGCVRN*SCSQDHWALLGRGDVWLA* REWLCKDALMLSSLRF*AFLRT*AFFFFFFNF*R NFFSVNSWNCILNP*R*ALIGRSKVLWLTPSFI DEAAEAWGCEQPAHSPHLLDLTSAR*TGMPWGV EGH*ECFI*YVNAHKKMSRNEEQQLSVVPAFIII YVKVKFMYSKFVIRIFTRTLF*YL*LSCGFECS LTEGMSNLY*QGRNTVILDKHRHFKFQFPF*

Frame 1

RKWRSKGKPEALCGFHGFVSRKLLLYLGKPQAL Q*ESCKLAFRRRCLSKLS*PWKRGGKKADKQ** HQQETSIRLPSPEDSVFT*TTSKS*SLFPSKWEL LWTLEHTEDSTFFKTLFSGNFPENRLLPEDWWS LI*RLAMKSQGQHWYSSSDKNCKVSFREKLLII DSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDV FEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQH LNCTKEEVERLLPTRQRVSLFRNLLYELSEGID SENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGK IDEDNLTCLEDLCKTVVPKLLRNIEKYKREKAI QIVTPPVDKEAESYQGEEELVSQTDVKTFLEAL PQESWQNKHAGSNEGSCVQDESEPQRPLCHCQQP QLYLPEGQTRNP*RC*DPESCVPVAWVHSAYTQ *CDESGNGDGPAEAEVQSSPCRRGLLRVLYSDP WEIWSCLLFG*GPHSHSGDHVSLHSPAVP*TG*K T*TLFHPGLPR*RDTAFRIHRSRCSEP*AGTHF PAGQYSCRG*LPTWSGHCPRLCILSACGGRQLV YSVSV*SSEEIGPKT*RHLIHPHCCQR*CESKSG QTGNKETDAPACFHTKEKTSIPCAPGCTFIIAE SFCWFLDLKRIIGYNLQPPAQHRNRWSPPVILE TGNTVFSDTVNSDFLFLLQV*MLENFLFFGDSLI LSPRLECRGAITAHCSLDLPGSSDPPTSASQVA ETTGVCPCTANFLFFLWRWGFTMLPKLVSNSWA QAILPPQLLKVLGLQA*NTVPGLGTRCILRFLGV QKPRS*PRLSLDCLSRQLPLSYNSVSPLHALKH WTVRSQSTHPLSDLPLPKTSLLHI**GENLVYA RPISCFCVRKVLT*EVFIWLETGFPVGR*WLIYT QLLCKQKLYNLMSYSILDWVR*LMPVIPVLWEA KAGRSLEVRSSRPAWPIRQNLIITKNTKISQVW RRAPVIPATREAETGESLESRRQRLW*AKMTQLH SSLGNRARPCLKKKFNIGVGTFQLPLTEHPIQI D*SKEGNLLPLSH*NPGVDNTGFRQSLNQDSIY RPAPFSWPDVLRAGRCSRLQWTVPTLLLLLHFAP LAQGMRREAVSETEAVLRITGLFLAEGMSGLPE GSGSVRTP*CFLH*DFEHFYVLELFFFFFSISR GTFSLLIPGTVF*ILKGEPS*GDPKSCG*RLHL* MRQLRPGDVNNLLTVLIYWI*LQPGELECLGAW KGIRSVSFDM*MLIKKCQGMKNNNSQWCLHL*L FM*KSNSCTVNLL*EYSQEHCSDISDCHVDLNVA *QRECLIYIDRAGTPSS*TNTATLSSSSLS

Frame 2

GNGDPKESLKHFVASTGSFLGSFCFTWGNPKLY SEKVVN*PLGDAVCQSYLNPGKGEGKRQISSDD ISRKLVSGYPVLKIQFSLKQPASLEVSSQANGS FFGPWSTQRILLSLKLCFQAISLRTVYFQKIGGA *SEGWP*NLKVNIGIPVQIKTVK*AFVRSF*LL IQTWGSKMWRTSSFSA*DWSPTRSWRSPAQPQM FLNISWQRIC*VRKTLSSWQNSSISYGRRSCCST STVPKRKWSDCCPPDKGFLCLETCSTNCQKALT QRT*RT*SSF*KTRFPKLK*PP*VSWHF*RNKV K*MKII*HAWRTSAKQLYLNF*ET*RNTKERKLS R**HLL*TRKPSRIKERKN*FPKQMLRHSWKPY RRSPGKISMQVVMRAAVYRMNRNHRGLCVIVNN HSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHN NVTKVEMEMVLQKQKCNPAHADGDCFVFCILTH GRFGAVYSSDEALIPIREIMSHFTALQCPRLAE KPKLFFIQACQGEEIQPSVSIEADALNPEQAPTS LQDSIPAEADFLLGLATVPGYVSFRHVEEGSWY IQSLCNHLKKLVPRHEDILSILTAVNDDVSRRV DKQGTKKQMPQPAFTLRKKLVFPVPLDALSL*QR VFVGS*TSNESLAITSSLLPSTGIGGLHLSF*K QETPCFLTQSILIFFFFCKSKC*KTFFFLEIVS FCHPDWSAGGQSRLTVVSTSQVQAILPPQPPK*L RLQVCVHAQLTFYFFCGDGVSLCCLSWSQTPGL KRSSHLSFSKFWDYRHEILCLAWGPGAF*GSLV FKNHVLSLD*A*IASLDNYPLVIILCPLCMPLNI GQ*GHSPPTLSLISPFLRLLFCTSSEVKIWSMP GPFPAFV*GRCSHRKFLFG*RQVSL*EDDGSFT LSCSASRNFTT*CHIPFWTGCGDSCL*SQYSGKP RQADHLRSGVRDQPGQYGKTSSLLKTQKLARCG GEHL*SQLLGRLRQENLLNPGGRGCGEPR*HNC TPAWATGRDLV*KKNSILGLEHFSCH*QNTQFKL TEAKKGIYCLFHIETQEWITLASGKA*IRTQST GQHLSLGRMSSGLADAVDCSGQSPPCYCYYTLL LWPKA*GERLCQKLKLFSGSLGSSWQRGCLACLK GVAL*GRLDAFFIKILSIFTYLSFFFFFFQFLE ELFLC*FLELYFESLKVSPHREIQSPVVNAFIY R*GS*GLGM*TTCSQSSFTGFDFSQVNWNALGRG RALGVFHLICECS*KNVKE*RTTTLSGACIYNY LCESQIHVQ*ICYKNIHKNTVLISLIVMWI*M* LDRGNV*SILTGQEHRHLRQTPPL*VPVPFL