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Sequences

Sequence OGG1.mAug05

ATCGCTTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCGAGATCGCGCCATCACACTCCAGCCTAGGCGACAGAGTGAGACTCCGTCTCAAAGAAAAAAAA CTTGCAGCCTGATAGTTAAGATACAGCAACCCCAAATCCCTATGCTAAAAGGTGAGAATGGCCCAGATAAAGGTCATGTCTCCTAGCTCCCTGCTTTTTC ATGCCATCCTCCAGAAGGGAAGAAATTAAATAATCCATCCTCCTACTCCAGGCGACTAGAAGGCAGGCTGCCTCAGGGCCACACACTGGGACTTGGACTC AACCTGATGGGCTTCTGGGCCCAGCCCCAGACAAACCCCCGGCAAACGTCCCATTCCGAGGAAAGCATGAGCAGATGGAGTATGGAAGAAATGCCCAAGA CGGCAGGCAGCAGCTGTGGCGGCCGGCGGGACGACAATCCGAGGAGAGGCCTCTGATGTCCTGAGGTCTCAGAGGACGCCTAAAGGCCTTGAATGGGACA AGCTTAGCGGGCGGGCGCAGAAGAGAATAATACTCTGGAGACACTTCCCGAGGGCTCTGGGGCCGGAGCTGTGTTCGCTCCGGTTCTTGGTGAAGACAGG GTTCGTGGGAGGCGGCCCAAGGAGGGCGAACGCCTAAGACTGCAAAGGCTCGGGGGAGAACGGCTCTCGGAGAACGGGCTGGGGAAGGACGTGGCTCTGA AGACGGACAGCCCTGAGGAACCGCGGGGCGCCCAGATGGAACTCGTTAGCGCCCCGAGTGCAGACAATCCCGGAGGGGGAAAGGCGAGCAGCTGGCAGAG AGCCCAGTGCCGGCCAACCGCGCGAGCGCCTCAGAACGGCCCGCCCACCCTGATTTCTCATTGGCGCCTCCTACCTCCTCCTCGGATTGGCTACCTCTAG GTGAAATGAGCGGTGGTTGAGCCCTACTTCCGGTGGTGCTGTGGTCTGCCCCTGGAGAACCCAGAAGAACACAGCTGTGCGCGCCCACAGGCTCTGGGGG CGGGAGAAGATAAGTCGCAAGGAGGGGGCGGGACCTACACCTCAGGAAAGCCGGAGAATTGGGGCACGAAGCGGGGCTTTGATGACCCGCAAAGGGCGAG GCATGCAGGAGGTGGAGGAATTAAGTGAAACAGGGAAGGTTGTTAAACAGCACCGTGTGGGCGAGGCCTTAAGGGTCGTGGTCCTTGTCTGGGCGGGGTC TTTGGGCGTCGACGAGGCCTGGTTCTGGGTAGGCGGGGCTACTACGGGGCGGTGCCTGCTGTGGAAATGCCTGCCCGCGCGCTTCTGCCCAGGCGCATGG GGCATCGTACTCTAGCCTCCACTCCTGCCCTGTGGGCCTCCATCCCGTGCCCTCGCTCTGAGCTGCGCCTGGACCTGGTTCTGCCTTCTGGACAATCTTT CCGGTGGAGGGAGCAAAGTCCTGCACACTGGAGTGGTGTACTAGCGGATCAAGTATGGACACTGACTCAGACTGAGGAGCAGCTCCACTGCACTGTGTAC CGAGGAGACAAGAGCCAGGCTAGCAGGCCCACACCAGACGAGCTGGAGGCCGTGCGCAAGTACTTCCAGCTAGATGTTACCCTGGCTCAACTGTATCACC ACTGGGGTTCCGTGGACTCCCACTTCCAAGAGGTGGCTCAGAAATTCCAAGGTGTGCGACTGCTGCGACAAGACCCCATCGAATGCCTTTTCTCTTTTAT CTGTTCCTCCAACAACAACATCGCCCGCATCACTGGCATGGTGGAGCGGCTGTGCCAGGCTTTTGGACCTCGGCTCATCCAGCTTGATGATGTCACCTAC CATGGCTTCCCCAGCCTGCAGGCCCTGGCTGGTGGCTGACTGCATCTGCCTGATGGCCCTAGACAAGCCCCAGGCTGTGCCCGTGGATGTCCATATGTGG CACATTGCCCAACGTGACTACAGCTGGCACCCTACCACGTCCCAGGCGAAGGGACCGAGCCCCCAGACCAACAAGGAACTGGGAAACTTTTTCCGGAGCC TGTGGGGACCTTATGCTGGCTGGGCCCAAGCGGTGAGTGTACCTAGGTGTCCTCCCTAGGTTTCCTCTCCTCCAGCCCAGACCCAGTGGACTCTTCCACC ACCGCCCCAGGTGGCCCTAAAGGACTCTCCAGCCACCCCTGTCCCAACCCCAGTGGATTCTCATTGCCTTCGGCCCTGTTCCCCAAGGACTCTTCCACCT CCCAACACTGTCACTAGTCTCACCAGCCCTGACCCCAGTGTACCCTCCTCCCCACACAGACTCCACCCTCCTACAGGTGCTGTTCAGTGCCGACCTGCGC CAATCCCGCCATGCTCAGGAGCCACCAGCAAAGCGCAGAAAGGGTTCCAAAGGGCCGGAAGGCTAGATGGGGCACCCTGGACAAAGAAATTCCCCAAGCA CCTTCCCCTCCATTCCCCACTTCTCTCTCCCCATCCCCACCCAGTCTCATGTTGGGGAGGGGCCTCCCTGTGACTACCTCAAAGGCCAGGCACCCCCAAA TCAAGCAGTCAGTTTGCACAACAAGATGGGGTGGGGGATATTGAGGGAGACAGCGCTAAGGATGGTTTTATCTTCCCTTTATTACAAGAAGGAACAATAA AATAGAAACATTTGTATGGA

OGG1.u.f.12 (forward primer)
OGG1.u.r.14 (reverse primer)
Single exon skipping

Frame 0

IA*TREAELAVSRDRAITLQPRRQSETPSQRKK TCSLIVKIQQPQIPMLKGENGPDKGHVS*LPAFS CHPPEGKKLNNPSSYSRRLEGRLPQGHTLGLGL NLMGFWAQPQTNPRQTSHSEESMSRWSMEEMPK TAGSSCGGRRDDNPRRGL*CPEVSEDA*RP*MGQ A*RAGAEENNTLETLPEGSGAGAVFAPVLGEDR VRGRRPKEGERLRLQRLGGERLSENGLGKDVAL KTDSPEEPRGAQMELVSAPSADNPGGGKASSWQR AQCRPTARAPQNGPPTLISHWRLLPPPRIGYL* VK*AVVEPYFRWCCGLPLENPEEHSCARPQALG AGEDKSQGGGGTYTSGKPENWGTKRGFDDPQRAR HAGGGGIK*NREGC*TAPCGRGLKGRGPCLGGV FGRRRGLVLGRRGYYGAVPAVEMPARALLPRRM GHRTLASTPALWASIPCPRSELRLDLVLPSGQSF RWREQSPAHWSGVLADQVWTLTQTEEQLHCTVY RGDKSQASRPTPDELEAVRKYFQLDVTLAQLYH HWGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFI CSSNNNIARITGMVERLCQAFGPRLIQLDDVTY HGFPSLQALAGG*LHLPDGPRQAPGCARGCPYV AHCPT*LQLAPYHVPGEGTEPPDQQGTGKLFPEP VGTLCWLGPSGECT*VSSLGFLSSSPDPVDSST TAPGGPKGLSSHPCPNPSGFSLPSALFPKDSST SQHCH*SHQP*PQCTLLPTQTPPSYRCCSVPTCA NPAMLRSHQQSAERVPKGRKARWGTLDKEIPQA PSPPFPTSLSPSPPSLMLGRGLPVTTSKARHPQ IKQSVCTTRWGGGY*GRQR*GWFYLPFITRRNNK IETFVW

Frame 1

SLEPGRRSLQ*AEIAPSHSSLGDRVRLRLKEKK LAA**LRYSNPKSLC*KVRMAQIKVMSPSSLLF HAILQKGRN*IIHPPTPGD*KAGCLRATHWDLDS T*WASGPSPRQTPGKRPIPRKA*ADGVWKKCPR RQAAAVAAGGTTIRGEASDVLRSQRTPKGLEWD KLSGRAQKRIILWRHFPRALGPELCSLRFLVKTG FVGGGPRRANA*DCKGSGENGSRRTGWGRTWL* RRTALRNRGAPRWNSLAPRVQTIPEGERRAAGR EPSAGQPRERLRTARPP*FLIGASYLLLGLATSR *NERWLSPTSGGAVVCPWRTQKNTAVRAHRLWG REKISRKEGAGPTPQESRRIGARSGALMTRKGR GMQEVEELSETGKVVKQHRVGEALRVVVLVWAGS LGVDEAWFWVGGATTGRCLLWKCLPARFCPGAW GIVL*PPLLPCGPPSRALALSCAWTWFCLLDNL SGGGSKVLHTGVVY*RIKYGH*LRLRSSSTALCT EETRARLAGPHQTSWRPCASTSS*MLPWLNCIT TGVPWTPTSKRWLRNSKVCDCCDKTPSNAFSLL SVPPTTTSPASLAWWSGCARLLDLGSSSLMMSPT MASPACRPWLVADCICLMALDKPQAVPVDVHMW HIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRS LWGPYAGWAQAVSVPRCPP*VSSPPAQTQWTLPP PPQVALKDSPATPVPTPVDSHCLRPCSPRTLPP PNTVTSLTSPDPSVPSSPHRLHPPTGAVQCRPA PIPPCSGATSKAQKGFQRAGRLDGAPWTKKFPKH LPLHSPLLSPHPHPVSCWGGASL*LPQRPGTPK SSSQFAQQDGVGDIEGDSAKDGFIFPLLQEGTI K*KHLYG

Frame 2

RLNPGGGACSEPRSRHHTPA*ATE*DSVSKKKN LQPDS*DTATPNPYAKR*EWPR*RSCLLAPCFF MPSSRREEIK*SILLLQATRRQAASGPHTGTWT QPDGLLGPAPDKPPANVPFRGKHEQMEYGRNAQD GRQQLWRPAGRQSEERPLMS*GLRGRLKALNGT SLAGGRRRE*YSGDTSRGLWGRSCVRSGSW*RQ GSWEAAQGGRTPKTAKARGRTALGERAGEGRGSE DGQP*GTAGRPDGTR*RPECRQSRRGKGEQLAE SPVPANRASASERPAHPDFSLAPPTSSSDWLPL GEMSGG*ALLPVVLWSAPGEPRRTQLCAPTGSGG GRR*VARRGRDLHLRKAGELGHEAGL**PAKGE ACRRWRN*VKQGRLLNSTVWARP*GSWSLSGRG LWASTRPGSG*AGLLRGGACCGNACPRASAQAHG ASYSSLHSCPVGLHPVPSL*AAPGPGSAFWTIF PVEGAKSCTLEWCTSGSSMDTDSD*GAAPLHCV PRRQEPG*QAHTRRAGGRAQVLPARCYPGSTVSP LGFRGLPLPRGGSEIPRCATAATRPHRMPFLFY LFLQQQHRPHHWHGGAAVPGFWTSAHPA**CHL PWLPQPAGPGWWLTASA*WP*TSPRLCPWMSICG TLPNVTTAGTLPRPRRRDRAPRPTRNWETFSGA CGDLMLAGPKR*VYLGVLPRFPLLQPRPSGLFH HRPRWP*RTLQPPLSQPQWILIAFGPVPQGLFHL PTLSLVSPALTPVYPPPHTDSTLLQVLFSADLR QSRHAQEPPAKRRKGSKGPEG*MGHPGQRNSPS TFPSIPHFSLPIPTQSHVGEGPPCDYLKGQAPPN QAVSLHNKMGWGILRETALRMVLSSLYYKKEQ* NRNICM

Sequence OGG1.iAug05

ATCGCTTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCGAGATCGCGCCATCACACTCCAGCCTAGGCGACAGAGTGAGACTCCGTCTCAAAGAAAAAAAA CTTGCAGCCTGATAGTTAAGATACAGCAACCCCAAATCCCTATGCTAAAAGGTGAGAATGGCCCAGATAAAGGTCATGTCTCCTAGCTCCCTGCTTTTTC ATGCCATCCTCCAGAAGGGAAGAAATTAAATAATCCATCCTCCTACTCCAGGCGACTAGAAGGCAGGCTGCCTCAGGGCCACACACTGGGACTTGGACTC AACCTGATGGGCTTCTGGGCCCAGCCCCAGACAAACCCCCGGCAAACGTCCCATTCCGAGGAAAGCATGAGCAGATGGAGTATGGAAGAAATGCCCAAGA CGGCAGGCAGCAGCTGTGGCGGCCGGCGGGACGACAATCCGAGGAGAGGCCTCTGATGTCCTGAGGTCTCAGAGGACGCCTAAAGGCCTTGAATGGGACA AGCTTAGCGGGCGGGCGCAGAAGAGAATAATACTCTGGAGACACTTCCCGAGGGCTCTGGGGCCGGAGCTGTGTTCGCTCCGGTTCTTGGTGAAGACAGG GTTCGTGGGAGGCGGCCCAAGGAGGGCGAACGCCTAAGACTGCAAAGGCTCGGGGGAGAACGGCTCTCGGAGAACGGGCTGGGGAAGGACGTGGCTCTGA AGACGGACAGCCCTGAGGAACCGCGGGGCGCCCAGATGGAACTCGTTAGCGCCCCGAGTGCAGACAATCCCGGAGGGGGAAAGGCGAGCAGCTGGCAGAG AGCCCAGTGCCGGCCAACCGCGCGAGCGCCTCAGAACGGCCCGCCCACCCTGATTTCTCATTGGCGCCTCCTACCTCCTCCTCGGATTGGCTACCTCTAG GTGAAATGAGCGGTGGTTGAGCCCTACTTCCGGTGGTGCTGTGGTCTGCCCCTGGAGAACCCAGAAGAACACAGCTGTGCGCGCCCACAGGCTCTGGGGG CGGGAGAAGATAAGTCGCAAGGAGGGGGCGGGACCTACACCTCAGGAAAGCCGGAGAATTGGGGCACGAAGCGGGGCTTTGATGACCCGCAAAGGGCGAG GCATGCAGGAGGTGGAGGAATTAAGTGAAACAGGGAAGGTTGTTAAACAGCACCGTGTGGGCGAGGCCTTAAGGGTCGTGGTCCTTGTCTGGGCGGGGTC TTTGGGCGTCGACGAGGCCTGGTTCTGGGTAGGCGGGGCTACTACGGGGCGGTGCCTGCTGTGGAAATGCCTGCCCGCGCGCTTCTGCCCAGGCGCATGG GGCATCGTACTCTAGCCTCCACTCCTGCCCTGTGGGCCTCCATCCCGTGCCCTCGCTCTGAGCTGCGCCTGGACCTGGTTCTGCCTTCTGGACAATCTTT CCGGTGTGCGACTGCTGCGACAAGACCCCATCGAATGCCTTTTCTCTTTTATCTGTTCCTCCAACAACAACATCGCCCGCATCACTGGCATGGTGGAGCG GCTGTGCCAGGCTTTTGGACCTCGGCTCATCCAGCTTGATGATGTCACCTACCATGGCTTCCCCAGCCTGCAGGCCCTGGCTGGGCCAGAGGTGGAGGCT CATCTCAGGAAGCTGGGCCTGGGCTATCGTGCCCGTTACGTGAGTGCCAGTGCCCGAGCCATCCTGGAAGAACAGGGCGGGCTAGCCTGGCTGCAGCAGC TACGAGAGTCCTCATATGAGGAGGCCCACAAGGCCCTCTGCATCCTGCCTGGAGTGGGCACCAAGGTGGCTGACTGCATCTGCCTGATGGCCCTAGACAA GCCCCAGGCTGTGCCCGTGGATGTCCATATGTGGCACATTGCCCAACGTGACTACAGCTGGCACCCTACCACGTCCCAGGCGAAGGGACCGAGCCCCCAG ACCAACAAGGAACTGGGAAACTTTTTCCGGAGCCTGTGGGGACCTTATGCTGGCTGGGCCCAAGCGGTGAGTGTACCTAGGTGTCCTCCCTAGGTTTCCT CTCCTCCAGCCCAGACCCAGTGGACTCTTCCACCACCGCCCCAGGTGGCCCTAAAGGACTCTCCAGCCACCCCTGTCCCAACCCCAGTGGATTCTCATTG CCTTCGGCCCTGTTCCCCAAGGACTCTTCCACCTCCCAACACTGTCACTAGTCTCACCAGCCCTGACCCCAGTGTACCCTCCTCCCCACACAGACTCCAC CCTCCTACAGGTGCTGTTCAGTGCCGACCTGCGCCAATCCCGCCATGCTCAGGAGCCACCAGCAAAGCGCAGAAAGGGTTCCAAAGGGCCGGAAGGCTAG ATGGGGCACCCTGGACAAAGAAATTCCCCAAGCACCTTCCCCTCCATTCCCCACTTCTCTCTCCCCATCCCCACCCAGTCTCATGTTGGGGAGGGGCCTC CCTGTGACTACCTCAAAGGCCAGGCACCCCCAAATCAAGCAGTCAGTTTGCACAACAAGATGGGGTGGGGGATATTGAGGGAGACAGCGCTAAGGATGGT TTTATCTTCCCTTTATTACAAGAAGGAACAATAAAATAGAAACATTTGTATGGA

OGG1.u.f.12 (forward primer)
OGG1.u.r.14 (reverse primer)
Single exon skipping

Frame 0

IA*TREAELAVSRDRAITLQPRRQSETPSQRKK TCSLIVKIQQPQIPMLKGENGPDKGHVS*LPAFS CHPPEGKKLNNPSSYSRRLEGRLPQGHTLGLGL NLMGFWAQPQTNPRQTSHSEESMSRWSMEEMPK TAGSSCGGRRDDNPRRGL*CPEVSEDA*RP*MGQ A*RAGAEENNTLETLPEGSGAGAVFAPVLGEDR VRGRRPKEGERLRLQRLGGERLSENGLGKDVAL KTDSPEEPRGAQMELVSAPSADNPGGGKASSWQR AQCRPTARAPQNGPPTLISHWRLLPPPRIGYL* VK*AVVEPYFRWCCGLPLENPEEHSCARPQALG AGEDKSQGGGGTYTSGKPENWGTKRGFDDPQRAR HAGGGGIK*NREGC*TAPCGRGLKGRGPCLGGV FGRRRGLVLGRRGYYGAVPAVEMPARALLPRRM GHRTLASTPALWASIPCPRSELRLDLVLPSGQSF RCATAATRPHRMPFLFYLFLQQQHRPHHWHGGA AVPGFWTSAHPA**CHLPWLPQPAGPGWARGGG SSQEAGPGLSCPLRECQCPSHPGRTGRASLAAAA TRVLI*GGPQGPLHPAWSGHQGG*LHLPDGPRQ APGCARGCPYVAHCPT*LQLAPYHVPGEGTEPP DQQGTGKLFPEPVGTLCWLGPSGECT*VSSLGFL SSSPDPVDSSTTAPGGPKGLSSHPCPNPSGFSL PSALFPKDSSTSQHCH*SHQP*PQCTLLPTQTP PSYRCCSVPTCANPAMLRSHQQSAERVPKGRKAR WGTLDKEIPQAPSPPFPTSLSPSPPSLMLGRGL PVTTSKARHPQIKQSVCTTRWGGGY*GRQR*GW FYLPFITRRNNKIETFVW

Frame 1

SLEPGRRSLQ*AEIAPSHSSLGDRVRLRLKEKK LAA**LRYSNPKSLC*KVRMAQIKVMSPSSLLF HAILQKGRN*IIHPPTPGD*KAGCLRATHWDLDS T*WASGPSPRQTPGKRPIPRKA*ADGVWKKCPR RQAAAVAAGGTTIRGEASDVLRSQRTPKGLEWD KLSGRAQKRIILWRHFPRALGPELCSLRFLVKTG FVGGGPRRANA*DCKGSGENGSRRTGWGRTWL* RRTALRNRGAPRWNSLAPRVQTIPEGERRAAGR EPSAGQPRERLRTARPP*FLIGASYLLLGLATSR *NERWLSPTSGGAVVCPWRTQKNTAVRAHRLWG REKISRKEGAGPTPQESRRIGARSGALMTRKGR GMQEVEELSETGKVVKQHRVGEALRVVVLVWAGS LGVDEAWFWVGGATTGRCLLWKCLPARFCPGAW GIVL*PPLLPCGPPSRALALSCAWTWFCLLDNL SGVRLLRQDPIECLFSFICSSNNNIARITGMVER LCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEA HLRKLGLGYRARYVSASARAILEEQGGLAWLQQ LRESSYEEAHKALCILPGVGTKVADCICLMALDK PQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQ TNKELGNFFRSLWGPYAGWAQAVSVPRCPP*VS SPPAQTQWTLPPPPQVALKDSPATPVPTPVDSHC LRPCSPRTLPPPNTVTSLTSPDPSVPSSPHRLH PPTGAVQCRPAPIPPCSGATSKAQKGFQRAGRL DGAPWTKKFPKHLPLHSPLLSPHPHPVSCWGGAS L*LPQRPGTPKSSSQFAQQDGVGDIEGDSAKDG FIFPLLQEGTIK*KHLYG

Frame 2

RLNPGGGACSEPRSRHHTPA*ATE*DSVSKKKN LQPDS*DTATPNPYAKR*EWPR*RSCLLAPCFF MPSSRREEIK*SILLLQATRRQAASGPHTGTWT QPDGLLGPAPDKPPANVPFRGKHEQMEYGRNAQD GRQQLWRPAGRQSEERPLMS*GLRGRLKALNGT SLAGGRRRE*YSGDTSRGLWGRSCVRSGSW*RQ GSWEAAQGGRTPKTAKARGRTALGERAGEGRGSE DGQP*GTAGRPDGTR*RPECRQSRRGKGEQLAE SPVPANRASASERPAHPDFSLAPPTSSSDWLPL GEMSGG*ALLPVVLWSAPGEPRRTQLCAPTGSGG GRR*VARRGRDLHLRKAGELGHEAGL**PAKGE ACRRWRN*VKQGRLLNSTVWARP*GSWSLSGRG LWASTRPGSG*AGLLRGGACCGNACPRASAQAHG ASYSSLHSCPVGLHPVPSL*AAPGPGSAFWTIF PVCDCCDKTPSNAFSLLSVPPTTTSPASLAWWS GCARLLDLGSSSLMMSPTMASPACRPWLGQRWRL ISGSWAWAIVPVT*VPVPEPSWKNRAG*PGCSS YESPHMRRPTRPSASCLEWAPRWLTASA*WP*T SPRLCPWMSICGTLPNVTTAGTLPRPRRRDRAPR PTRNWETFSGACGDLMLAGPKR*VYLGVLPRFP LLQPRPSGLFHHRPRWP*RTLQPPLSQPQWILI AFGPVPQGLFHLPTLSLVSPALTPVYPPPHTDST LLQVLFSADLRQSRHAQEPPAKRRKGSKGPEG* MGHPGQRNSPSTFPSIPHFSLPIPTQSHVGEGP PCDYLKGQAPPNQAVSLHNKMGWGILRETALRMV LSSLYYKKEQ*NRNICM

Sequence OGG1.fAug05

ATCGCTTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCGAGATCGCGCCATCACACTCCAGCCTAGGCGACAGAGTGAGACTCCGTCTCAAAGAAAAAAAA CTTGCAGCCTGATAGTTAAGATACAGCAACCCCAAATCCCTATGCTAAAAGGTGAGAATGGCCCAGATAAAGGTCATGTCTCCTAGCTCCCTGCTTTTTC ATGCCATCCTCCAGAAGGGAAGAAATTAAATAATCCATCCTCCTACTCCAGGCGACTAGAAGGCAGGCTGCCTCAGGGCCACACACTGGGACTTGGACTC AACCTGATGGGCTTCTGGGCCCAGCCCCAGACAAACCCCCGGCAAACGTCCCATTCCGAGGAAAGCATGAGCAGATGGAGTATGGAAGAAATGCCCAAGA CGGCAGGCAGCAGCTGTGGCGGCCGGCGGGACGACAATCCGAGGAGAGGCCTCTGATGTCCTGAGGTCTCAGAGGACGCCTAAAGGCCTTGAATGGGACA AGCTTAGCGGGCGGGCGCAGAAGAGAATAATACTCTGGAGACACTTCCCGAGGGCTCTGGGGCCGGAGCTGTGTTCGCTCCGGTTCTTGGTGAAGACAGG GTTCGTGGGAGGCGGCCCAAGGAGGGCGAACGCCTAAGACTGCAAAGGCTCGGGGGAGAACGGCTCTCGGAGAACGGGCTGGGGAAGGACGTGGCTCTGA AGACGGACAGCCCTGAGGAACCGCGGGGCGCCCAGATGGAACTCGTTAGCGCCCCGAGTGCAGACAATCCCGGAGGGGGAAAGGCGAGCAGCTGGCAGAG AGCCCAGTGCCGGCCAACCGCGCGAGCGCCTCAGAACGGCCCGCCCACCCTGATTTCTCATTGGCGCCTCCTACCTCCTCCTCGGATTGGCTACCTCTAG GTGAAATGAGCGGTGGTTGAGCCCTACTTCCGGTGGTGCTGTGGTCTGCCCCTGGAGAACCCAGAAGAACACAGCTGTGCGCGCCCACAGGCTCTGGGGG CGGGAGAAGATAAGTCGCAAGGAGGGGGCGGGACCTACACCTCAGGAAAGCCGGAGAATTGGGGCACGAAGCGGGGCTTTGATGACCCGCAAAGGGCGAG GCATGCAGGAGGTGGAGGAATTAAGTGAAACAGGGAAGGTTGTTAAACAGCACCGTGTGGGCGAGGCCTTAAGGGTCGTGGTCCTTGTCTGGGCGGGGTC TTTGGGCGTCGACGAGGCCTGGTTCTGGGTAGGCGGGGCTACTACGGGGCGGTGCCTGCTGTGGAAATGCCTGCCCGCGCGCTTCTGCCCAGGCGCATGG GGCATCGTACTCTAGCCTCCACTCCTGCCCTGTGGGCCTCCATCCCGTGCCCTCGCTCTGAGCTGCGCCTGGACCTGGTTCTGCCTTCTGGACAATCTTT CCGGTGGAGGGAGCAAAGTCCTGCACACTGGAGTGGTGTACTAGCGGATCAAGTATGGACACTGACTCAGACTGAGGAGCAGCTCCACTGCACTGTGTAC CGAGGAGACAAGAGCCAGGCTAGCAGGCCCACACCAGACGAGCTGGAGGCCGTGCGCAAGTACTTCCAGCTAGATGTTACCCTGGCTCAACTGTATCACC ACTGGGGTTCCGTGGACTCCCACTTCCAAGAGGTGGCTCAGAAATTCCAAGGTGTGCGACTGCTGCGACAAGACCCCATCGAATGCCTTTTCTCTTTTAT CTGTTCCTCCAACAACAACATCGCCCGCATCACTGGCATGGTGGAGCGGCTGTGCCAGGCTTTTGGACCTCGGCTCATCCAGCTTGATGATGTCACCTAC CATGGCTTCCCCAGCCTGCAGGCCCTGGCTGGGCCAGAGGTGGAGGCTCATCTCAGGAAGCTGGGCCTGGGCTATCGTGCCCGTTACGTGAGTGCCAGTG CCCGAGCCATCCTGGAAGAACAGGGCGGGCTAGCCTGGCTGCAGCAGCTACGAGAGTCCTCATATGAGGAGGCCCACAAGGCCCTCTGCATCCTGCCTGG AGTGGGCACCAAGGTGGCTGACTGCATCTGCCTGATGGCCCTAGACAAGCCCCAGGCTGTGCCCGTGGATGTCCATATGTGGCACATTGCCCAACGTGAC TACAGCTGGCACCCTACCACGTCCCAGGCGAAGGGACCGAGCCCCCAGACCAACAAGGAACTGGGAAACTTTTTCCGGAGCCTGTGGGGACCTTATGCTG GCTGGGCCCAAGCGGTGAGTGTACCTAGGTGTCCTCCCTAGGTTTCCTCTCCTCCAGCCCAGACCCAGTGGACTCTTCCACCACCGCCCCAGGTGGCCCT AAAGGACTCTCCAGCCACCCCTGTCCCAACCCCAGTGGATTCTCATTGCCTTCGGCCCTGTTCCCCAAGGACTCTTCCACCTCCCAACACTGTCACTAGT CTCACCAGCCCTGACCCCAGTGTACCCTCCTCCCCACACAGACTCCACCCTCCTACAGGTGCTGTTCAGTGCCGACCTGCGCCAATCCCGCCATGCTCAG GAGCCACCAGCAAAGCGCAGAAAGGGTTCCAAAGGGCCGGAAGGCTAGATGGGGCACCCTGGACAAAGAAATTCCCCAAGCACCTTCCCCTCCATTCCCC ACTTCTCTCTCCCCATCCCCACCCAGTCTCATGTTGGGGAGGGGCCTCCCTGTGACTACCTCAAAGGCCAGGCACCCCCAAATCAAGCAGTCAGTTTGCA CAACAAGATGGGGTGGGGGATATTGAGGGAGACAGCGCTAAGGATGGTTTTATCTTCCCTTTATTACAAGAAGGAACAATAAAATAGAAACATTTGTATG GA

OGG1.u.f.12 (forward primer)
OGG1.u.r.14 (reverse primer)
Single exon skipping

Frame 0

IA*TREAELAVSRDRAITLQPRRQSETPSQRKK TCSLIVKIQQPQIPMLKGENGPDKGHVS*LPAFS CHPPEGKKLNNPSSYSRRLEGRLPQGHTLGLGL NLMGFWAQPQTNPRQTSHSEESMSRWSMEEMPK TAGSSCGGRRDDNPRRGL*CPEVSEDA*RP*MGQ A*RAGAEENNTLETLPEGSGAGAVFAPVLGEDR VRGRRPKEGERLRLQRLGGERLSENGLGKDVAL KTDSPEEPRGAQMELVSAPSADNPGGGKASSWQR AQCRPTARAPQNGPPTLISHWRLLPPPRIGYL* VK*AVVEPYFRWCCGLPLENPEEHSCARPQALG AGEDKSQGGGGTYTSGKPENWGTKRGFDDPQRAR HAGGGGIK*NREGC*TAPCGRGLKGRGPCLGGV FGRRRGLVLGRRGYYGAVPAVEMPARALLPRRM GHRTLASTPALWASIPCPRSELRLDLVLPSGQSF RWREQSPAHWSGVLADQVWTLTQTEEQLHCTVY RGDKSQASRPTPDELEAVRKYFQLDVTLAQLYH HWGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFI CSSNNNIARITGMVERLCQAFGPRLIQLDDVTY HGFPSLQALAGPEVEAHLRKLGLGYRARYVSAS ARAILEEQGGLAWLQQLRESSYEEAHKALCILPG VGTKVADCICLMALDKPQAVPVDVHMWHIAQRD YSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYA GWAQAVSVPRCPP*VSSPPAQTQWTLPPPPQVAL KDSPATPVPTPVDSHCLRPCSPRTLPPPNTVTS LTSPDPSVPSSPHRLHPPTGAVQCRPAPIPPCS GATSKAQKGFQRAGRLDGAPWTKKFPKHLPLHSP LLSPHPHPVSCWGGASL*LPQRPGTPKSSSQFA QQDGVGDIEGDSAKDGFIFPLLQEGTIK*KHLY G

Frame 1

SLEPGRRSLQ*AEIAPSHSSLGDRVRLRLKEKK LAA**LRYSNPKSLC*KVRMAQIKVMSPSSLLF HAILQKGRN*IIHPPTPGD*KAGCLRATHWDLDS T*WASGPSPRQTPGKRPIPRKA*ADGVWKKCPR RQAAAVAAGGTTIRGEASDVLRSQRTPKGLEWD KLSGRAQKRIILWRHFPRALGPELCSLRFLVKTG FVGGGPRRANA*DCKGSGENGSRRTGWGRTWL* RRTALRNRGAPRWNSLAPRVQTIPEGERRAAGR EPSAGQPRERLRTARPP*FLIGASYLLLGLATSR *NERWLSPTSGGAVVCPWRTQKNTAVRAHRLWG REKISRKEGAGPTPQESRRIGARSGALMTRKGR GMQEVEELSETGKVVKQHRVGEALRVVVLVWAGS LGVDEAWFWVGGATTGRCLLWKCLPARFCPGAW GIVL*PPLLPCGPPSRALALSCAWTWFCLLDNL SGGGSKVLHTGVVY*RIKYGH*LRLRSSSTALCT EETRARLAGPHQTSWRPCASTSS*MLPWLNCIT TGVPWTPTSKRWLRNSKVCDCCDKTPSNAFSLL SVPPTTTSPASLAWWSGCARLLDLGSSSLMMSPT MASPACRPWLGQRWRLISGSWAWAIVPVT*VPV PEPSWKNRAG*PGCSSYESPHMRRPTRPSASCL EWAPRWLTASA*WP*TSPRLCPWMSICGTLPNVT TAGTLPRPRRRDRAPRPTRNWETFSGACGDLML AGPKR*VYLGVLPRFPLLQPRPSGLFHHRPRWP *RTLQPPLSQPQWILIAFGPVPQGLFHLPTLSLV SPALTPVYPPPHTDSTLLQVLFSADLRQSRHAQ EPPAKRRKGSKGPEG*MGHPGQRNSPSTFPSIP HFSLPIPTQSHVGEGPPCDYLKGQAPPNQAVSLH NKMGWGILRETALRMVLSSLYYKKEQ*NRNICM

Frame 2

RLNPGGGACSEPRSRHHTPA*ATE*DSVSKKKN LQPDS*DTATPNPYAKR*EWPR*RSCLLAPCFF MPSSRREEIK*SILLLQATRRQAASGPHTGTWT QPDGLLGPAPDKPPANVPFRGKHEQMEYGRNAQD GRQQLWRPAGRQSEERPLMS*GLRGRLKALNGT SLAGGRRRE*YSGDTSRGLWGRSCVRSGSW*RQ GSWEAAQGGRTPKTAKARGRTALGERAGEGRGSE DGQP*GTAGRPDGTR*RPECRQSRRGKGEQLAE SPVPANRASASERPAHPDFSLAPPTSSSDWLPL GEMSGG*ALLPVVLWSAPGEPRRTQLCAPTGSGG GRR*VARRGRDLHLRKAGELGHEAGL**PAKGE ACRRWRN*VKQGRLLNSTVWARP*GSWSLSGRG LWASTRPGSG*AGLLRGGACCGNACPRASAQAHG ASYSSLHSCPVGLHPVPSL*AAPGPGSAFWTIF PVEGAKSCTLEWCTSGSSMDTDSD*GAAPLHCV PRRQEPG*QAHTRRAGGRAQVLPARCYPGSTVSP LGFRGLPLPRGGSEIPRCATAATRPHRMPFLFY LFLQQQHRPHHWHGGAAVPGFWTSAHPA**CHL PWLPQPAGPGWARGGGSSQEAGPGLSCPLRECQC PSHPGRTGRASLAAAATRVLI*GGPQGPLHPAW SGHQGG*LHLPDGPRQAPGCARGCPYVAHCPT* LQLAPYHVPGEGTEPPDQQGTGKLFPEPVGTLCW LGPSGECT*VSSLGFLSSSPDPVDSSTTAPGGP KGLSSHPCPNPSGFSLPSALFPKDSSTSQHCH* SHQP*PQCTLLPTQTPPSYRCCSVPTCANPAMLR SHQQSAERVPKGRKARWGTLDKEIPQAPSPPFP TSLSPSPPSLMLGRGLPVTTSKARHPQIKQSVC TTRWGGGY*GRQR*GWFYLPFITRRNNKIETFVW