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Sequences

Sequence BID.jAug05

GAAGGAGGAAGCGCGCGGGGCGCCATAAGGAGGAAGCGGGTAGTCGACCGTGTCCGCGCGCCTGGGAGACGCTGCCTCGGCCCGGACGCGCCCGCGCCCC CGCGGCTGGAGGGTGGTCGCCACTGGGACACTGTGAACCAGGAGTGAGTCGGAGCTGCCGCGCTGCCCAGGCCATGGACTGTGAGATTCTGAAAGTCAAG AAGACATCATCCGGAATATTGCCAGGCACCTCGCCCAGGTCGGGGACAGCATGGACCGTAGCATCCCTCCGGGCCTGGTGAACGGCCTGGCCCTGCAGCT CAGGAACACCAGCCGGTCGGAGGAGGACCGGAACAGGGACCTGGCCACTGCCCTGGAGCAGCTGCTGCAGGCCTACCCTAGAGACATGGAGAAGGAGAAG ACCATGCTGGTGCTGGCCCTGCTGCTGGCCAAGAAGGTGGCCAGTCACACGCCGTCCTTGCTCCGTGATGTCTTTCACACAACAGTGAATTTTATTAACC AGAACCTACGCACCTACGTGAGGAGCTTAGCCAGAAATGGGATGGACTGAACGGACAGTTCCAGAAGTGTGACTGGCTAAAGCTCGATGTGGTCACAGCT GTATAGCTGCTTCCAGTGTAGACGGAGCCCTGGCATGTCAACAGCGTTCCTAGAGAAGACAGGCTGGAAGATAGCTGTGACTTCTATTTTAAAGACAATG TTAAACTTATAACCCACTTTAAAATATCTACATTAATATACTTGAATGAAAATGTCCATATCACACACATTGCTGTGAACAGGAAACTCCTGTGACCACA ACATGAGGCCACTGGAGACGCATATGAGTAAGGGCACTGACGGACTCATGATTTCTTCTTACCAGATGCTTTCCTGTTCTTTAAGAGTTTAAAATCATCA GAAAGGAAAAACAAACTCTATATTGTTCAGCATGCAATACATACCACGCTAGGGCTGGCTCAATTGAAAGTGGGCAAAAGCTTACAAATACTAAAAAGAA GTGCTGCCGCGCAGTGTGGAGGCCACTGTTTGGAAATAAATCTTCCTAACACTACGACTTTTCATGTTTTGGAGTGGACTTTTAAAAAAGTTTTCCAACC ACAATGGAAACAGGTTGAACCACACTGCGCCTACACATCCATCCATACGTCAGCCATTATAATCAGATTCTCACTGGGGGAGGCATTTTCTTCCCAAAGG AGCTGTATGCAGTCATCACCCGGAACTAATGGGAAAGTGTTCTTAAGCAGCAAGTGACTCTGGACCACCTCTCTCACACACTGACTCTTCCACAGCATCT TCACCTGCTTCTGTTTCACTTGAATTCATACAGTAGGCCACCATTTTATAACAGGTCTTAGTGTAAATTCTTCCAGACCAAGTCTGAGATAGTCTTGGTT GTAAAGCAAGACCGTCACCCCTTCTCCCAAAGCCAACATTATAAAAAGATTCCATTGTCTCAAACACAAATGTTCCAGTCTTGAGCACTTCCCAGCCATG GTGACTCGGGCATATCCTGGCAGTTGGTGGATTTTGCCCTGTAACACAATCCTTGTGGATATGATTCAAAGGTGACTTTAATTCAGAGAATGTGTTTTCC TTTCTGTTTTAAAAATATTTGAATTAAGTGATGGAAATTCTTTTGTTAAACATCAAAAGCTTTCTCCTTGAAAAGATGCTTGGTGTATCTGAAAGTCACG TGGGACATTTGGTGCATTCAGAAGGTCAAATCATTCCTGACCTCTCCTCTTAGGACCCAGCATTAACTGCTGCGATACTCAAGGCTTCCTTAAAGGATCA CAGCACTGGCGCCTAGTTTTACTGTCCAGCAACTTTATTAGTTGTGCTAGCTGAGAATTGGAATATAGAGTCCTTTGAATGTTACGATCTTGTTTTCAAA ACCTGGAGTCAAACCAATTAAGTATGGACTTAACAAAGACAATTGATGATGTGAAATGATACCACCTGTCAAGGGCATAGTTACCATGTGGATAGAAAGA TGAGTCCACTGATTATCTTCAAATCCCATGTATTCTCTCTAGCACGTTGCTTCTGACAGAAAGAATAACTCACAGATTTGAAGTTTGTTCCTTTCCCCTG ATGAAGAGTAGATTGGCCAAAAGGTAGATGACAGGAAGGAAGAGGAGCCAGAATGACCCACAGTGATCAGTTCAGCAGTGCAGAGCGGCAGTGCAGAGGC TCATGGAACTCACACGGAAAAAGGAAACACATGCTGCTTAAAATGCACGATAACTTAATTATCCAAATTACCATTCAATTCCGGTATTTTTGAGATGAAA GCATTTGAGCCAACACTAAATTGACCTTAATTAAGGAATGAGGTAGGAAGAGGCACTTTTAATCTGGAGGAAGAAATAAATGGAAGACTGTAATAGGAAA AATACAGGTCTAGGAAAAAAATAATTTTTTTCCTTTGATGCTGGCCAAGGACCCCTCTACATAATACAGTTCTCCTGCTGGAAAGCATCAGGGCAAACAG AGTTATTCCAAACTCTGCAACAGGGAAGACTGTACTTTGACCTTCTTTTCCTGGGGAAAGGGAACAACTAGTAATCTTTAAATGTCAAAACTTTTCTTCT AAATAGTACATTCATTAACCAGTTTCTTCTGGTGGTGCAAAGAACACTCACCACAGTGAGCAATACCACTATTCAATTTCCCCTTTGGAGAGGTGACAGC GGGGTAGAATCACCTGGAGTCAGCTGCTAGTCTTTAACTGATGACAAGGCCTTGCAAATACCCCTGAGAACAATTTCACTCTGAGCTCACAGGGAAGCAG CAGTCTGGTGTGGGCTCCTGTGGTGTAACCATCAAATGTGGAAGACCTGATGGTGTTAGTGTGTGGGGATGCCGGGCTGAAATTCAACAGCCTTGCAAAA AGAAAGGGAAGATGGGATGTGTTAATATTGTAGTGGCATGCACTTTCCAGCTCTCCATGGAGCTCTCTTTATATATGAGGTAATTGAATGTCACTATTCT GTACCATACAGCAGGTATTATCTAGCCAAGGTTATAATTACCATGAAGTGCTGTGGAATGTAGTAGGAGGCTTTTCACTGGG

BID.F1 (forward primer)
BID.R1 (reverse primer)
Multiple exon skipping

Frame 0

EGGSARGAIRRKRVVDRVRAPGRRCLGPDAPAP PRLEGGRHWDTVNQE*VGAAALPRPWTVRF*KSR RHHPEYCQAPRPGRGQHGP*HPSGPGERPGPAA QEHQPVGGGPEQGPGHCPGAAAAGLP*RHGEGE DHAGAGPAAGQEGGQSHAVLAP*CLSHNSEFY*P EPTHLREELSQKWDGLNGQFQKCDWLKLDVVTA V*LLPV*TEPWHVNSVPREDRLEDSCDFYFKDN VKLITHFKISTLIYLNENVHITHIAVNRKLL*PQ HEATGDAYE*GH*RTHDFFLPDAFLFFKSLKSS ERKNKLYIVQHAIHTTLGLAQLKVGKSLQILKR SAAAQCGGHCLEINLPNTTTFHVLEWTFKKVFQP QWKQVEPHCAYTSIHTSAIIIRFSLGEAFSSQR SCMQSSPGTNGKVFLSSK*LWTTSLTH*LFHSI FTCFCFT*IHTVGHHFITGLSVNSSRPSLR*SWL *SKTVTPSPKANIIKRFHCLKHKCSSLEHFPAM VTRAYPGSWWILPCNTILVDMIQR*L*FRECVF LSVLKIFELSDGNSFVKHQKLSP*KDAWCI*KSR GTFGAFRRSNHS*PLLLGPSINCCDTQGFLKGS QHWRLVLLSSNFISCAS*ELEYRVL*MLRSCFQ NLESNQLSMDLTKTIDDVK*YHLSRA*LPCG*KD ESTDYLQIPCILSSTLLLTERITHRFEVCSFPL MKSRLAKR*MTGRKRSQNDPQ*SVQQCRAAVQR LMELTRKKETHAA*NAR*LNYPNYHSIPVFLR*K HLSQH*IDLN*GMR*EEALLIWRKK*MEDCNRK NTGLGKK*FFSFDAGQGPLYIIQFSCWKASGQT ELFQTLQQGRLYFDLLFLGKGNN**SLNVKTFLL NSTFINQFLLVVQRTLTTVSNTTIQFPLWRGDS GVESPGVSC*SLTDDKALQIPLRTISL*AHREA AVWCGLLWCNHQMWKT*WC*CVGMPG*NSTALQK EREDGMC*YCSGMHFPALHGALFIYEVIECHYS VPYSRYYLAKVIITMKCCGM**EAFHW

Frame 1

KEEARGAP*GGSG*STVSARLGDAASARTRPRP RGWRVVATGTL*TRSESELPRCPGHGL*DSESQ EDIIRNIARHLAQVGDSMDRSIPPGLVNGLALQL RNTSRSEEDRNRDLATALEQLLQAYPRDMEKEK TMLVLALLLAKKVASHTPSLLRDVFHTTVNFIN QNLRTYVRSLARNGMD*TDSSRSVTG*SSMWSQL YSCFQCRRSPGMSTAFLEKTGWKIAVTSILKTM LNL*PTLKYLH*YT*MKMSISHTLL*TGNSCDH NMRPLETHMSKGTDGLMISSYQMLSCSLRV*NHQ KGKTNSILFSMQYIPR*GWLN*KWAKAYKY*KE VLPRSVEATVWK*IFLTLRLFMFWSGLLKKFSN HNGNRLNHTAPTHPSIRQPL*SDSHWGRHFLPKG AVCSHHPELMGKCS*AASDSGPPLSHTDSSTAS SPASVSLEFIQ*ATIL*QVLV*ILPDQV*DSLG CKARPSPLLPKPTL*KDSIVSNTNVPVLSTSQPW *LGHILAVGGFCPVTQSLWI*FKGDFNSENVFS FLF*KYLN*VMEILLLNIKSFLLEKMLGVSESH VGHLVHSEGQIIPDLSS*DPALTAAILKASLKDH STGA*FYCPATLLVVLAENWNIESFECYDLVFK TWSQTN*VWT*QRQLMM*NDTTCQGHSYHVDRK MSPLIIFKSHVFSLARCF*QKE*LTDLKFVPFP* *RVDWPKGR*QEGRGARMTHSDQFSSAERQCRG SWNSHGKRKHMLLKMHDNLIIQITIQFRYF*DE SI*ANTKLTLIKE*GRKRHF*SGGRNKWKTVIGK IQV*EKNNFFPLMLAKDPST*YSSPAGKHQGKQ SYSKLCNREDCTLTFFSWGKGTTSNL*MSKLFF *IVHSLTSFFWWCKEHSPQ*AIPLFNFPFGEVTA G*NHLESAASL*LMTRPCKYP*EQFHSELTGKQ QSGVGSCGVTIKCGRPDGVSVWGCRAEIQQPCK KKGKMGCVNIVVACTFQLSMELSLYMR*LNVTIL YHTAGII*PRL*LP*SAVECSRRLFTG

Frame 2

RRKRAGRHKEEAGSRPCPRAWETLPRPGRARAP AAGGWSPLGHCEPGVSRSCRAAQAMDCEILKVK KTSSGILPGTSPRSGTAWTVASLRAW*TAWPCS SGTPAGRRRTGTGTWPLPWSSCCRPTLETWRRRR PCWCWPCCWPRRWPVTRRPCSVMSFTQQ*ILLT RTYAPT*GA*PEMGWTERTVPEV*LAKARCGHS CIAASSVDGALACQQRS*RRQAGR*L*LLF*RQC *TYNPL*NIYINILE*KCPYHTHCCEQETPVTT T*GHWRRI*VRALTDS*FLLTRCFPVL*EFKII RKEKQTLYCSACNTYHARAGSIESGQKLTNTKKK CCRAVWRPLFGNKSS*HYDFSCFGVDF*KSFPT TMETG*TTLRLHIHPYVSHYNQILTGGGIFFPK ELYAVITRN*WESVLKQQVTLDHLSHTLTLPQHL HLLLFHLNSYSRPPFYNRS*CKFFQTKSEIVLV VKQDRHPFSQSQHYKKIPLSQTQMFQS*ALPSH GDSGISWQLVDFAL*HNPCGYDSKVTLIQRMCFP FCFKNI*IK*WKFFC*TSKAFSLKRCLVYLKVT WDIWCIQKVKSFLTSPLRTQH*LLRYSRLP*RI TALAPSFTVQQLY*LC*LRIGI*SPLNVTILFSK PGVKPIKYGLNKDN**CEMIPPVKGIVTMWIER *VH*LSSNPMYSL*HVASDRKNNSQI*SLFLSP DEE*IGQKVDDRKEEEPE*PTVISSAVQSGSAEA HGTHTEKGNTCCLKCTIT*LSKLPFNSGIFEMK AFEPTLN*P*LRNEVGRGTFNLEEEINGRL**E KYRSRKKIIFFL*CWPRTPLHNTVLLLESIRANR VIPNSATGKTVL*PSFPGEREQLVIFKCQNFSS K*YIH*PVSSGGAKNTHHSEQYHYSISPLER*Q RGRITWSQLLVFN**QGLANTPENNFTLSSQGSS SLVWAPVV*PSNVEDLMVLVCGDAGLKFNSLAK RKGRWDVLIL*WHALSSSPWSSLYI*GN*MSLF CTIQQVLSSQGYNYHEVLWNVVGGFSL

Sequence BID.fAug05

GAAGGAGGAAGCGCGCGGGGCGCCATAAGGAGGAAGCGGGTAGTCGACCGTGTCCGCGCGCCTGGGAGACGCTGCCTCGGCCCGGACGCGCCCGCGCCCC CGCGGCTGGAGGGTGGTCGCCACTGGGACACTGTGAACCAGGAGTGAGTCGGAGCTGCCGCGCTGCCCAGGCCATGGACTGTGAGGTCAACAACGGTTCC AGCCTCAGGGATGAGTGCATCACAAACCTACTGGTGTTTGGCTTCCTCCAAAGCTGTTCTGACAACAGCTTCCGCAGAGAGCTGGACGCACTGGGCCACG AGCTGCCAGTGCTGGCTCCCCAGTGGGAGGGCTACGATGAGCTGCAGACTGATGGCAACCGCAGCAGCCACTCCCGCTTGGGAAGAATAGAGGCAGGGGC GTCAGACAATAACACAGCAAGTGCTGAGGAAGAAACGGAGGCGGCAGGGAGCGTGGCAGTTGAGCGTGGCCTTCATGGAGCTGCGACAGTGATTCTGAAA GTCAAGAAGACATCATCCGGAATATTGCCAGGCACCTCGCCCAGGTCGGGGACAGCATGGACCGTAGCATCCCTCCGGGCCTGGTGAACGGCCTGGCCCT GCAGCTCAGGAACACCAGCCGGTCGGAGGAGGACCGGAACAGGGACCTGGCCACTGCCCTGGAGCAGCTGCTGCAGGCCTACCCTAGAGACATGGAGAAG GAGAAGACCATGCTGGTGCTGGCCCTGCTGCTGGCCAAGAAGGTGGCCAGTCACACGCCGTCCTTGCTCCGTGATGTCTTTCACACAACAGTGAATTTTA TTAACCAGAACCTACGCACCTACGTGAGGAGCTTAGCCAGAAATGGGATGGACTGAACGGACAGTTCCAGAAGTGTGACTGGCTAAAGCTCGATGTGGTC ACAGCTGTATAGCTGCTTCCAGTGTAGACGGAGCCCTGGCATGTCAACAGCGTTCCTAGAGAAGACAGGCTGGAAGATAGCTGTGACTTCTATTTTAAAG ACAATGTTAAACTTATAACCCACTTTAAAATATCTACATTAATATACTTGAATGAAAATGTCCATTTACACGTATTTGAATGGCCTTCATATCATCCACA CATGAATCTGCACATCTGTAAATCTACACACGGTGCCTTTATTTCCACTGTGCAGGTTCCCACTTAAAAATTAAATTGGAAAGCAGGTTTCAAGGAAGTA GAAACAAAATACAATTTTTTTGGTAAAAAAAAATTACTGTTTATTAAAGTACAACCATAGAGGATGGTCTTACAGCAGGCAGTATCCTGTTTGAGGAAAG CAAGAATCAGAGAAGGAACATACCCCTTACAAATGAAAAATTCCACTCAAAATAGGGACTATCTATCTTAATACTAAGGAACCAACAATCTTCCTGTTTA AAAAACCACATGGCACAGAGATTCTGAACTAAAGTGCTGCACTCAAATGATGGGAAGTCCGGCCCCAGTACACAGGGGCTTGACTTTTTCAACTTCGTTT CCTTTGTTGGAGTCAAAAAGAACCACTTGTGGTTCTAAAAGGTGTGAAGGTGATTTAAGGGCCCAGGTCAGCCACTGTTTGTTTACAAAATCAGGTAACT AACTGCATACACTTTTTCTCTTTCCATGACATCAAGACTTTGCTAAAGACATGAAGCCACGGGTGCCAGAAGCTACTGCGATGCCCCGGGAGTTAGCCCC CTGGTAATAGCTGTAAACTTCCAATTTCTAGCCATACGCTCAGCTCATCCATGCCTCAGAAGTGCATCTGGAGAGAACAGGTTTCTAAGCATAAAAGATG AAAGAGCAGTTGGACTTTTTAAAAATTCAGCAAAGTGGTTCCCTCTCTTAGGGACAGTCAAAACCAAGTCACTTAGGTAGTACCAAAATAAATAAGGAAA AGCTTAGCTTTAGAAACAGTGCAACACTGGTCTGCTGTTCCAGTGGTAAGCTATGTCCCAGGAATCAGTTTAAAAGCACGACAGTGGATGCTGGGTCCAT ATCACACACATTGCTGTGAACAGGAAACTCCTGTGACCACAACATGAGGCCACTGGAGACGCATATGAGTAAGGGCACTGACGGACTCATGATTTCTTCT TACCAGATGCTTTCCTGTTCTTTAAGAGTTTAAAATCATCAGAAAGGAAAAACAAACTCTATATTGTTCAGCATGCAATACATACCACGCTAGGGCTGGC TCAATTGAAAGTGGGCAAAAGCTTACAAATACTAAAAAGAAGTGCTGCCGCGCAGTGTGGAGGCCACTGTTTGGAAATAAATCTTCCTAACACTACGACT TTTCATGTTTTGGAGTGGACTTTTAAAAAAGTTTTCCAACCACAATGGAAACAGGTTGAACCACACTGCGCCTACACATCCATCCATACGTCAGCCATTA TAATCAGATTCTCACTGGGGGAGGCATTTTCTTCCCAAAGGAGCTGTATGCAGTCATCACCCGGAACTAATGGGAAAGTGTTCTTAAGCAGCAAGTGACT CTGGACCACCTCTCTCACACACTGACTCTTCCACAGCATCTTCACCTGCTTCTGTTTCACTTGAATTCATACAGTAGGCCACCATTTTATAACAGGTCTT AGTGTAAATTCTTCCAGACCAAGTCTGAGATAGTCTTGGTTGTAAAGCAAGACCGTCACCCCTTCTCCCAAAGCCAACATTATAAAAAGATTCCATTGTC TCAAACACAAATGTTCCAGTCTTGAGCACTTCCCAGCCATGGTGACTCGGGCATATCCTGGCAGTTGGTGGATTTTGCCCTGTAACACAATCCTTGTGGA TATGATTCAAAGGTGACTTTAATTCAGAGAATGTGTTTTCCTTTCTGTTTTAAAAATATTTGAATTAAGTGATGGAAATTCTTTTGTTAAACATCAAAAG CTTTCTCCTTGAAAAGATGCTTGGTGTATCTGAAAGTCACGTGGGACATTTGGTGCATTCAGAAGGTCAAATCATTCCTGACCTCTCCTCTTAGGACCCA GCATTAACTGCTGCGATACTCAAGGCTTCCTTAAAGGATCACAGCACTGGCGCCTAGTTTTACTGTCCAGCAACTTTATTAGTTGTGCTAGCTGAGAATT GGAATATAGAGTCCTTTGAATGTTACGATCTTGTTTTCAAAACCTGGAGTCAAACCAATTAAGTATGGACTTAACAAAGACAATTGATGATGTGAAATGA TACCACCTGTCAAGGGCATAGTTACCATGTGGATAGAAAGATGAGTCCACTGATTATCTTCAAATCCCATGTATTCTCTCTAGCACGTTGCTTCTGACAG AAAGAATAACTCACAGATTTGAAGTTTGTTCCTTTCCCCTGATGAAGAGTAGATTGGCCAAAAGGTAGATGACAGGAAGGAAGAGGAGCCAGAATGACCC ACAGTGATCAGTTCAGCAGTGCAGAGCGGCAGTGCAGAGGCTCATGGAACTCACACGGAAAAAGGAAACACATGCTGCTTAAAATGCACGATAACTTAAT TATCCAAATTACCATTCAATTCCGGTATTTTTGAGATGAAAGCATTTGAGCCAACACTAAATTGACCTTAATTAAGGAATGAGGTAGGAAGAGGCACTTT TAATCTGGAGGAAGAAATAAATGGAAGACTGTAATAGGAAAAATACAGGTCTAGGAAAAAAATAATTTTTTTCCTTTGATGCTGGCCAAGGACCCCTCTA CATAATACAGTTCTCCTGCTGGAAAGCATCAGGGCAAACAGAGTTATTCCAAACTCTGCAACAGGGAAGACTGTACTTTGACCTTCTTTTCCTGGGGAAA GGGAACAACTAGTAATCTTTAAATGTCAAAACTTTTCTTCTAAATAGTACATTCATTAACCAGTTTCTTCTGGTGGTGCAAAGAACACTCACCACAGTGA GCAATACCACTATTCAATTTCCCCTTTGGAGAGGTGACAGCGGGGTAGAATCACCTGGAGTCAGCTGCTAGTCTTTAACTGATGACAAGGCCTTGCAAAT ACCCCTGAGAACAATTTCACTCTGAGCTCACAGGGAAGCAGCAGTCTGGTGTGGGCTCCTGTGGTGTAACCATCAAATGTGGAAGACCTGATGGTGTTAG TGTGTGGGGATGCCGGGCTGAAATTCAACAGCCTTGCAAAAAGAAAGGGAAGATGGGATGTGTTAATATTGTAGTGGCATGCACTTTCCAGCTCTCCATG GAGCTCTCTTTATATATGAGGTAATTGAATGTCACTATTCTGTACCATACAGCAGGTATTATCTAGCCAAGGTTATAATTACCATGAAGTGCTGTGGAAT GTAGTAGGAGGCTTTTCACTGGG

BID.F1 (forward primer)
BID.R1 (reverse primer)
Multiple exon skipping

Frame 0

EGGSARGAIRRKRVVDRVRAPGRRCLGPDAPAP PRLEGGRHWDTVNQE*VGAAALPRPWTVRSTTVP ASGMSASQTYWCLASSKAVLTTASAESWTHWAT SCQCWLPSGRATMSCRLMATAAATPAWEE*RQG RQTITQQVLRKKRRRQGAWQLSVAFMELRQ*F*K SRRHHPEYCQAPRPGRGQHGP*HPSGPGERPGP AAQEHQPVGGGPEQGPGHCPGAAAAGLP*RHGE GEDHAGAGPAAGQEGGQSHAVLAP*CLSHNSEFY *PEPTHLREELSQKWDGLNGQFQKCDWLKLDVV TAV*LLPV*TEPWHVNSVPREDRLEDSCDFYFK DNVKLITHFKISTLIYLNENVHLHVFEWPSYHPH MNLHICKSTHGAFISTVQVPT*KLNWKAGFKEV ETKYNFFGKKKLLFIKVQP*RMVLQQAVSCLRK ARIREGTYPLQMKNSTQNRDYLS*Y*GTNNLPV* KTTWHRDSELKCCTQMMGSPAPVHRGLTFSTSF PLLESKRTTCGSKRCEGDLRAQVSHCLFTKSGN *LHTLFLFP*HQDFAKDMKPRVPEATAMPRELAP W**L*TSNF*PYAQLIHASEVHLERTGF*A*KM KEQLDFLKIQQSGSLS*GQSKPSHLGSTKINKE KLSFRNSATLVCCSSGKLCPRNQFKSTTVDAGSI SHTLL*TGNSCDHNMRPLETHMSKGTDGLMISS YQMLSCSLRV*NHQKGKTNSILFSMQYIPR*GW LN*KWAKAYKY*KEVLPRSVEATVWK*IFLTLRL FMFWSGLLKKFSNHNGNRLNHTAPTHPSIRQPL *SDSHWGRHFLPKGAVCSHHPELMGKCS*AASD SGPPLSHTDSSTASSPASVSLEFIQ*ATIL*QVL V*ILPDQV*DSLGCKARPSPLLPKPTL*KDSIV SNTNVPVLSTSQPW*LGHILAVGGFCPVTQSLW I*FKGDFNSENVFSFLF*KYLN*VMEILLLNIKS FLLEKMLGVSESHVGHLVHSEGQIIPDLSS*DP ALTAAILKASLKDHSTGA*FYCPATLLVVLAEN WNIESFECYDLVFKTWSQTN*VWT*QRQLMM*ND TTCQGHSYHVDRKMSPLIIFKSHVFSLARCF*Q KE*LTDLKFVPFP**RVDWPKGR*QEGRGARMT HSDQFSSAERQCRGSWNSHGKRKHMLLKMHDNLI IQITIQFRYF*DESI*ANTKLTLIKE*GRKRHF *SGGRNKWKTVIGKIQV*EKNNFFPLMLAKDPS T*YSSPAGKHQGKQSYSKLCNREDCTLTFFSWGK GTTSNL*MSKLFF*IVHSLTSFFWWCKEHSPQ* AIPLFNFPFGEVTAG*NHLESAASL*LMTRPCK YP*EQFHSELTGKQQSGVGSCGVTIKCGRPDGVS VWGCRAEIQQPCKKKGKMGCVNIVVACTFQLSM ELSLYMR*LNVTILYHTAGII*PRL*LP*SAVE CSRRLFTG

Frame 1

KEEARGAP*GGSG*STVSARLGDAASARTRPRP RGWRVVATGTL*TRSESELPRCPGHGL*GQQRF QPQG*VHHKPTGVWLPPKLF*QQLPQRAGRTGPR AASAGSPVGGLR*AAD*WQPQQPLPLGKNRGRG VRQ*HSKC*GRNGGGRERGS*AWPSWSCDSDSE SQEDIIRNIARHLAQVGDSMDRSIPPGLVNGLAL QLRNTSRSEEDRNRDLATALEQLLQAYPRDMEK EKTMLVLALLLAKKVASHTPSLLRDVFHTTVNF INQNLRTYVRSLARNGMD*TDSSRSVTG*SSMWS QLYSCFQCRRSPGMSTAFLEKTGWKIAVTSILK TMLNL*PTLKYLH*YT*MKMSIYTYLNGLHIIH T*ICTSVNLHTVPLFPLCRFPLKN*IGKQVSRK* KQNTIFLVKKNYCLLKYNHRGWSYSRQYPV*GK QESEKEHTPYK*KIPLKIGTIYLNTKEPTIFLF KKPHGTEILN*SAALK*WEVRPQYTGA*LFQLRF LCWSQKEPLVVLKGVKVI*GPRSATVCLQNQVT NCIHFFSFHDIKTLLKT*SHGCQKLLRCPGS*P PGNSCKLPISSHTLSSSMPQKCIWREQVSKHKR* KSSWTF*KFSKVVPSLRDSQNQVT*VVPK*IRK SLALETVQHWSAVPVVSYVPGISLKARQWMLGP YHTHCCEQETPVTTT*GHWRRI*VRALTDS*FLL TRCFPVL*EFKIIRKEKQTLYCSACNTYHARAG SIESGQKLTNTKKKCCRAVWRPLFGNKSS*HYD FSCFGVDF*KSFPTTMETG*TTLRLHIHPYVSHY NQILTGGGIFFPKELYAVITRN*WESVLKQQVT LDHLSHTLTLPQHLHLLLFHLNSYSRPPFYNRS *CKFFQTKSEIVLVVKQDRHPFSQSQHYKKIPLS QTQMFQS*ALPSHGDSGISWQLVDFAL*HNPCG YDSKVTLIQRMCFPFCFKNI*IK*WKFFC*TSK AFSLKRCLVYLKVTWDIWCIQKVKSFLTSPLRTQ H*LLRYSRLP*RITALAPSFTVQQLY*LC*LRI GI*SPLNVTILFSKPGVKPIKYGLNKDN**CEM IPPVKGIVTMWIER*VH*LSSNPMYSL*HVASDR KNNSQI*SLFLSPDEE*IGQKVDDRKEEEPE*P TVISSAVQSGSAEAHGTHTEKGNTCCLKCTIT* LSKLPFNSGIFEMKAFEPTLN*P*LRNEVGRGTF NLEEEINGRL**EKYRSRKKIIFFL*CWPRTPL HNTVLLLESIRANRVIPNSATGKTVL*PSFPGE REQLVIFKCQNFSSK*YIH*PVSSGGAKNTHHSE QYHYSISPLER*QRGRITWSQLLVFN**QGLAN TPENNFTLSSQGSSSLVWAPVV*PSNVEDLMVL VCGDAGLKFNSLAKRKGRWDVLIL*WHALSSSPW SSLYI*GN*MSLFCTIQQVLSSQGYNYHEVLWN VVGGFSL

Frame 2

RRKRAGRHKEEAGSRPCPRAWETLPRPGRARAP AAGGWSPLGHCEPGVSRSCRAAQAMDCEVNNGS SLRDECITNLLVFGFLQSCSDNSFRRELDALGH ELPVLAPQWEGYDELQTDGNRSSHSRLGRIEAGA SDNNTASAEEETEAAGSVAVERGLHGAATVILK VKKTSSGILPGTSPRSGTAWTVASLRAW*TAWP CSSGTPAGRRRTGTGTWPLPWSSCCRPTLETWRR RRPCWCWPCCWPRRWPVTRRPCSVMSFTQQ*IL LTRTYAPT*GA*PEMGWTERTVPEV*LAKARCG HSCIAASSVDGALACQQRS*RRQAGR*L*LLF*R QC*TYNPL*NIYINILE*KCPFTRI*MAFISST HESAHL*IYTRCLYFHCAGSHLKIKLESRFQGS RNKIQFFW*KKITVY*STTIEDGLTAGSILFEES KNQRRNIPLTNEKFHSK*GLSILILRNQQSSCL KNHMAQRF*TKVLHSNDGKSGPSTQGLDFFNFV SFVGVKKNHLWF*KV*R*FKGPGQPLFVYKIR*L TAYTFSLSMTSRLC*RHEATGARSYCDAPGVSP LVIAVNFQFLAIRSAHPCLRSASGENRFLSIKD ERAVGLFKNSAKWFPLLGTVKTKSLR*YQNK*GK A*L*KQCNTGLLFQW*AMSQESV*KHDSGCWVH ITHIAVNRKLL*PQHEATGDAYE*GH*RTHDFF LPDAFLFFKSLKSSERKNKLYIVQHAIHTTLGLA QLKVGKSLQILKRSAAAQCGGHCLEINLPNTTT FHVLEWTFKKVFQPQWKQVEPHCAYTSIHTSAI IIRFSLGEAFSSQRSCMQSSPGTNGKVFLSSK*L WTTSLTH*LFHSIFTCFCFT*IHTVGHHFITGL SVNSSRPSLR*SWL*SKTVTPSPKANIIKRFHC LKHKCSSLEHFPAMVTRAYPGSWWILPCNTILVD MIQR*L*FRECVFLSVLKIFELSDGNSFVKHQK LSP*KDAWCI*KSRGTFGAFRRSNHS*PLLLGP SINCCDTQGFLKGSQHWRLVLLSSNFISCAS*EL EYRVL*MLRSCFQNLESNQLSMDLTKTIDDVK* YHLSRA*LPCG*KDESTDYLQIPCILSSTLLLT ERITHRFEVCSFPLMKSRLAKR*MTGRKRSQNDP Q*SVQQCRAAVQRLMELTRKKETHAA*NAR*LN YPNYHSIPVFLR*KHLSQH*IDLN*GMR*EEAL LIWRKK*MEDCNRKNTGLGKK*FFSFDAGQGPLY IIQFSCWKASGQTELFQTLQQGRLYFDLLFLGK GNN**SLNVKTFLLNSTFINQFLLVVQRTLTTV SNTTIQFPLWRGDSGVESPGVSC*SLTDDKALQI PLRTISL*AHREAAVWCGLLWCNHQMWKT*WC* CVGMPG*NSTALQKEREDGMC*YCSGMHFPALH GALFIYEVIECHYSVPYSRYYLAKVIITMKCCGM **EAFHW