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Sequences

Sequence BID.jAug05

GAAGGAGGAAGCGCGCGGGGCGCCATAAGGAGGAAGCGGGTAGTCGACCGTGTCCGCGCGCCTGGGAGACGCTGCCTCGGCCCGGACGCGCCCGCGCCCC CGCGGCTGGAGGGTGGTCGCCACTGGGACACTGTGAACCAGGAGTGAGTCGGAGCTGCCGCGCTGCCCAGGCCATGGACTGTGAGATTCTGAAAGTCAAG AAGACATCATCCGGAATATTGCCAGGCACCTCGCCCAGGTCGGGGACAGCATGGACCGTAGCATCCCTCCGGGCCTGGTGAACGGCCTGGCCCTGCAGCT CAGGAACACCAGCCGGTCGGAGGAGGACCGGAACAGGGACCTGGCCACTGCCCTGGAGCAGCTGCTGCAGGCCTACCCTAGAGACATGGAGAAGGAGAAG ACCATGCTGGTGCTGGCCCTGCTGCTGGCCAAGAAGGTGGCCAGTCACACGCCGTCCTTGCTCCGTGATGTCTTTCACACAACAGTGAATTTTATTAACC AGAACCTACGCACCTACGTGAGGAGCTTAGCCAGAAATGGGATGGACTGAACGGACAGTTCCAGAAGTGTGACTGGCTAAAGCTCGATGTGGTCACAGCT GTATAGCTGCTTCCAGTGTAGACGGAGCCCTGGCATGTCAACAGCGTTCCTAGAGAAGACAGGCTGGAAGATAGCTGTGACTTCTATTTTAAAGACAATG TTAAACTTATAACCCACTTTAAAATATCTACATTAATATACTTGAATGAAAATGTCCATATCACACACATTGCTGTGAACAGGAAACTCCTGTGACCACA ACATGAGGCCACTGGAGACGCATATGAGTAAGGGCACTGACGGACTCATGATTTCTTCTTACCAGATGCTTTCCTGTTCTTTAAGAGTTTAAAATCATCA GAAAGGAAAAACAAACTCTATATTGTTCAGCATGCAATACATACCACGCTAGGGCTGGCTCAATTGAAAGTGGGCAAAAGCTTACAAATACTAAAAAGAA GTGCTGCCGCGCAGTGTGGAGGCCACTGTTTGGAAATAAATCTTCCTAACACTACGACTTTTCATGTTTTGGAGTGGACTTTTAAAAAAGTTTTCCAACC ACAATGGAAACAGGTTGAACCACACTGCGCCTACACATCCATCCATACGTCAGCCATTATAATCAGATTCTCACTGGGGGAGGCATTTTCTTCCCAAAGG AGCTGTATGCAGTCATCACCCGGAACTAATGGGAAAGTGTTCTTAAGCAGCAAGTGACTCTGGACCACCTCTCTCACACACTGACTCTTCCACAGCATCT TCACCTGCTTCTGTTTCACTTGAATTCATACAGTAGGCCACCATTTTATAACAGGTCTTAGTGTAAATTCTTCCAGACCAAGTCTGAGATAGTCTTGGTT GTAAAGCAAGACCGTCACCCCTTCTCCCAAAGCCAACATTATAAAAAGATTCCATTGTCTCAAACACAAATGTTCCAGTCTTGAGCACTTCCCAGCCATG GTGACTCGGGCATATCCTGGCAGTTGGTGGATTTTGCCCTGTAACACAATCCTTGTGGATATGATTCAAAGGTGACTTTAATTCAGAGAATGTGTTTTCC TTTCTGTTTTAAAAATATTTGAATTAAGTGATGGAAATTCTTTTGTTAAACATCAAAAGCTTTCTCCTTGAAAAGATGCTTGGTGTATCTGAAAGTCACG TGGGACATTTGGTGCATTCAGAAGGTCAAATCATTCCTGACCTCTCCTCTTAGGACCCAGCATTAACTGCTGCGATACTCAAGGCTTCCTTAAAGGATCA CAGCACTGGCGCCTAGTTTTACTGTCCAGCAACTTTATTAGTTGTGCTAGCTGAGAATTGGAATATAGAGTCCTTTGAATGTTACGATCTTGTTTTCAAA ACCTGGAGTCAAACCAATTAAGTATGGACTTAACAAAGACAATTGATGATGTGAAATGATACCACCTGTCAAGGGCATAGTTACCATGTGGATAGAAAGA TGAGTCCACTGATTATCTTCAAATCCCATGTATTCTCTCTAGCACGTTGCTTCTGACAGAAAGAATAACTCACAGATTTGAAGTTTGTTCCTTTCCCCTG ATGAAGAGTAGATTGGCCAAAAGGTAGATGACAGGAAGGAAGAGGAGCCAGAATGACCCACAGTGATCAGTTCAGCAGTGCAGAGCGGCAGTGCAGAGGC TCATGGAACTCACACGGAAAAAGGAAACACATGCTGCTTAAAATGCACGATAACTTAATTATCCAAATTACCATTCAATTCCGGTATTTTTGAGATGAAA GCATTTGAGCCAACACTAAATTGACCTTAATTAAGGAATGAGGTAGGAAGAGGCACTTTTAATCTGGAGGAAGAAATAAATGGAAGACTGTAATAGGAAA AATACAGGTCTAGGAAAAAAATAATTTTTTTCCTTTGATGCTGGCCAAGGACCCCTCTACATAATACAGTTCTCCTGCTGGAAAGCATCAGGGCAAACAG AGTTATTCCAAACTCTGCAACAGGGAAGACTGTACTTTGACCTTCTTTTCCTGGGGAAAGGGAACAACTAGTAATCTTTAAATGTCAAAACTTTTCTTCT AAATAGTACATTCATTAACCAGTTTCTTCTGGTGGTGCAAAGAACACTCACCACAGTGAGCAATACCACTATTCAATTTCCCCTTTGGAGAGGTGACAGC GGGGTAGAATCACCTGGAGTCAGCTGCTAGTCTTTAACTGATGACAAGGCCTTGCAAATACCCCTGAGAACAATTTCACTCTGAGCTCACAGGGAAGCAG CAGTCTGGTGTGGGCTCCTGTGGTGTAACCATCAAATGTGGAAGACCTGATGGTGTTAGTGTGTGGGGATGCCGGGCTGAAATTCAACAGCCTTGCAAAA AGAAAGGGAAGATGGGATGTGTTAATATTGTAGTGGCATGCACTTTCCAGCTCTCCATGGAGCTCTCTTTATATATGAGGTAATTGAATGTCACTATTCT GTACCATACAGCAGGTATTATCTAGCCAAGGTTATAATTACCATGAAGTGCTGTGGAATGTAGTAGGAGGCTTTTCACTGGG

BID.F1 (forward primer)
BID.R1 (reverse primer)
Mutually exclusive exon skipping

Frame 0

EGGSARGAIRRKRVVDRVRAPGRRCLGPDAPAP PRLEGGRHWDTVNQE*VGAAALPRPWTVRF*KSR RHHPEYCQAPRPGRGQHGP*HPSGPGERPGPAA QEHQPVGGGPEQGPGHCPGAAAAGLP*RHGEGE DHAGAGPAAGQEGGQSHAVLAP*CLSHNSEFY*P EPTHLREELSQKWDGLNGQFQKCDWLKLDVVTA V*LLPV*TEPWHVNSVPREDRLEDSCDFYFKDN VKLITHFKISTLIYLNENVHITHIAVNRKLL*PQ HEATGDAYE*GH*RTHDFFLPDAFLFFKSLKSS ERKNKLYIVQHAIHTTLGLAQLKVGKSLQILKR SAAAQCGGHCLEINLPNTTTFHVLEWTFKKVFQP QWKQVEPHCAYTSIHTSAIIIRFSLGEAFSSQR SCMQSSPGTNGKVFLSSK*LWTTSLTH*LFHSI FTCFCFT*IHTVGHHFITGLSVNSSRPSLR*SWL *SKTVTPSPKANIIKRFHCLKHKCSSLEHFPAM VTRAYPGSWWILPCNTILVDMIQR*L*FRECVF LSVLKIFELSDGNSFVKHQKLSP*KDAWCI*KSR GTFGAFRRSNHS*PLLLGPSINCCDTQGFLKGS QHWRLVLLSSNFISCAS*ELEYRVL*MLRSCFQ NLESNQLSMDLTKTIDDVK*YHLSRA*LPCG*KD ESTDYLQIPCILSSTLLLTERITHRFEVCSFPL MKSRLAKR*MTGRKRSQNDPQ*SVQQCRAAVQR LMELTRKKETHAA*NAR*LNYPNYHSIPVFLR*K HLSQH*IDLN*GMR*EEALLIWRKK*MEDCNRK NTGLGKK*FFSFDAGQGPLYIIQFSCWKASGQT ELFQTLQQGRLYFDLLFLGKGNN**SLNVKTFLL NSTFINQFLLVVQRTLTTVSNTTIQFPLWRGDS GVESPGVSC*SLTDDKALQIPLRTISL*AHREA AVWCGLLWCNHQMWKT*WC*CVGMPG*NSTALQK EREDGMC*YCSGMHFPALHGALFIYEVIECHYS VPYSRYYLAKVIITMKCCGM**EAFHW

Frame 1

KEEARGAP*GGSG*STVSARLGDAASARTRPRP RGWRVVATGTL*TRSESELPRCPGHGL*DSESQ EDIIRNIARHLAQVGDSMDRSIPPGLVNGLALQL RNTSRSEEDRNRDLATALEQLLQAYPRDMEKEK TMLVLALLLAKKVASHTPSLLRDVFHTTVNFIN QNLRTYVRSLARNGMD*TDSSRSVTG*SSMWSQL YSCFQCRRSPGMSTAFLEKTGWKIAVTSILKTM LNL*PTLKYLH*YT*MKMSISHTLL*TGNSCDH NMRPLETHMSKGTDGLMISSYQMLSCSLRV*NHQ KGKTNSILFSMQYIPR*GWLN*KWAKAYKY*KE VLPRSVEATVWK*IFLTLRLFMFWSGLLKKFSN HNGNRLNHTAPTHPSIRQPL*SDSHWGRHFLPKG AVCSHHPELMGKCS*AASDSGPPLSHTDSSTAS SPASVSLEFIQ*ATIL*QVLV*ILPDQV*DSLG CKARPSPLLPKPTL*KDSIVSNTNVPVLSTSQPW *LGHILAVGGFCPVTQSLWI*FKGDFNSENVFS FLF*KYLN*VMEILLLNIKSFLLEKMLGVSESH VGHLVHSEGQIIPDLSS*DPALTAAILKASLKDH STGA*FYCPATLLVVLAENWNIESFECYDLVFK TWSQTN*VWT*QRQLMM*NDTTCQGHSYHVDRK MSPLIIFKSHVFSLARCF*QKE*LTDLKFVPFP* *RVDWPKGR*QEGRGARMTHSDQFSSAERQCRG SWNSHGKRKHMLLKMHDNLIIQITIQFRYF*DE SI*ANTKLTLIKE*GRKRHF*SGGRNKWKTVIGK IQV*EKNNFFPLMLAKDPST*YSSPAGKHQGKQ SYSKLCNREDCTLTFFSWGKGTTSNL*MSKLFF *IVHSLTSFFWWCKEHSPQ*AIPLFNFPFGEVTA G*NHLESAASL*LMTRPCKYP*EQFHSELTGKQ QSGVGSCGVTIKCGRPDGVSVWGCRAEIQQPCK KKGKMGCVNIVVACTFQLSMELSLYMR*LNVTIL YHTAGII*PRL*LP*SAVECSRRLFTG

Frame 2

RRKRAGRHKEEAGSRPCPRAWETLPRPGRARAP AAGGWSPLGHCEPGVSRSCRAAQAMDCEILKVK KTSSGILPGTSPRSGTAWTVASLRAW*TAWPCS SGTPAGRRRTGTGTWPLPWSSCCRPTLETWRRRR PCWCWPCCWPRRWPVTRRPCSVMSFTQQ*ILLT RTYAPT*GA*PEMGWTERTVPEV*LAKARCGHS CIAASSVDGALACQQRS*RRQAGR*L*LLF*RQC *TYNPL*NIYINILE*KCPYHTHCCEQETPVTT T*GHWRRI*VRALTDS*FLLTRCFPVL*EFKII RKEKQTLYCSACNTYHARAGSIESGQKLTNTKKK CCRAVWRPLFGNKSS*HYDFSCFGVDF*KSFPT TMETG*TTLRLHIHPYVSHYNQILTGGGIFFPK ELYAVITRN*WESVLKQQVTLDHLSHTLTLPQHL HLLLFHLNSYSRPPFYNRS*CKFFQTKSEIVLV VKQDRHPFSQSQHYKKIPLSQTQMFQS*ALPSH GDSGISWQLVDFAL*HNPCGYDSKVTLIQRMCFP FCFKNI*IK*WKFFC*TSKAFSLKRCLVYLKVT WDIWCIQKVKSFLTSPLRTQH*LLRYSRLP*RI TALAPSFTVQQLY*LC*LRIGI*SPLNVTILFSK PGVKPIKYGLNKDN**CEMIPPVKGIVTMWIER *VH*LSSNPMYSL*HVASDRKNNSQI*SLFLSP DEE*IGQKVDDRKEEEPE*PTVISSAVQSGSAEA HGTHTEKGNTCCLKCTIT*LSKLPFNSGIFEMK AFEPTLN*P*LRNEVGRGTFNLEEEINGRL**E KYRSRKKIIFFL*CWPRTPLHNTVLLLESIRANR VIPNSATGKTVL*PSFPGEREQLVIFKCQNFSS K*YIH*PVSSGGAKNTHHSEQYHYSISPLER*Q RGRITWSQLLVFN**QGLANTPENNFTLSSQGSS SLVWAPVV*PSNVEDLMVLVCGDAGLKFNSLAK RKGRWDVLIL*WHALSSSPWSSLYI*GN*MSLF CTIQQVLSSQGYNYHEVLWNVVGGFSL

Sequence BID.iAug05

GAAGGAGGAAGCGCGCGGGGCGCCATAAGGAGGAAGCGGGTAGTCGACCGTGTCCGCGCGCCTGGGAGACGCTGCCTCGGCCCGGACGCGCCCGCGCCCC CGCGGCTGGAGGGTGGTCAACAACGGTTCCAGCCTCAGGGATGAGTGCATCACAAACCTACTGGTGTTTGGCTTCCTCCAAAGCTGTTCTGACAACAGCT TCCGCAGAGAGCTGGACGCACTGGGCCACGAGCTGCCAGTGCTGGCTCCCCAGTGGGAGGGCTACGATGAGCTGCAGACTGATGGCAACCGCAGCAGCCA CTCCCGCTTGGGAAGAATAGAGATTCTGAAAGTCAAGAAGACATCATCCGGAATATTGCCAGGCACCTCGCCCAGGTCGGGGACAGCATGGACCGTAGCA TCCCTCCGGGCCTGGTGAACGGCCTGGCCCTGCAGCTCAGGAACACCAGCCGGTCGGAGGAGGACCGGAACAGGGACCTGGCCACTGCCCTGGAGCAGCT GCTGCAGGCCTACCCTAGAGACATGGAGAAGGAGAAGACCATGCTGGTGCTGGCCCTGCTGCTGGCCAAGAAGGTGGCCAGTCACACGCCGTCCTTGCTC CGTGATGTCTTTCACACAACAGTGAATTTTATTAACCAGAACCTACGCACCTACGTGAGGAGCTTAGCCAGAAATGGGATGGACTGAACGGACAGTTCCA GAAGTGTGACTGGCTAAAGCTCGATGTGGTCACAGCTGTATAGCTGCTTCCAGTGTAGACGGAGCCCTGGCATGTCAACAGCGTTCCTAGAGAAGACAGG CTGGAAGATAGCTGTGACTTCTATTTTAAAGACAATGTTAAACTTATAACCCACTTTAAAATATCTACATTAATATACTTGAATGAAAATGTCCATTTAC ACGTATTTGAATGGCCTTCATATCATCCACACATGAATCTGCACATCTGTAAATCTACACACGGTGCCTTTATTTCCACTGTGCAGGTTCCCACTTAAAA ATTAAATTGGAAAGCAGGTTTCAAGGAAGTAGAAACAAAATACAATTTTTTTGGTAAAAAAAAATTACTGTTTATTAAAGTACAACCATAGAGGATGGTC TTACAGCAGGCAGTATCCTGTTTGAGGAAAGCAAGAATCAGAGAAGGAACATACCCCTTACAAATGAAAAATTCCACTCAAAATAGGGACTATCTATCTT AATACTAAGGAACCAACAATCTTCCTGTTTAAAAAACCACATGGCACAGAGATTCTGAACTAAAGTGCTGCACTCAAATGATGGGAAGTCCGGCCCCAGT ACACAGGGGCTTGACTTTTTCAACTTCGTTTCCTTTGTTGGAGTCAAAAAGAACCACTTGTGGTTCTAAAAGGTGTGAAGGTGATTTAAGGGCCCAGGTC AGCCACTGTTTGTTTACAAAATCAGGTAACTAACTGCATACACTTTTTCTCTTTCCATGACATCAAGACTTTGCTAAAGACATGAAGCCACGGGTGCCAG AAGCTACTGCGATGCCCCGGGAGTTAGCCCCCTGGTAATAGCTGTAAACTTCCAATTTCTAGCCATACGCTCAGCTCATCCATGCCTCAGAAGTGCATCT GGAGAGAACAGGTTTCTAAGCATAAAAGATGAAAGAGCAGTTGGACTTTTTAAAAATTCAGCAAAGTGGTTCCCTCTCTTAGGGACAGTCAAAACCAAGT CACTTAGGTAGTACCAAAATAAATAAGGAAAAGCTTAGCTTTAGAAACAGTGCAACACTGGTCTGCTGTTCCAGTGGTAAGCTATGTCCCAGGAATCAGT TTAAAAGCACGACAGTGGATGCTGGGTCCATATCACACACATTGCTGTGAACAGGAAACTCCTGTGACCACAACATGAGGCCACTGGAGACGCATATGAG TAAGGGCACTGACGGACTCATGATTTCTTCTTACCAGATGCTTTCCTGTTCTTTAAGAGTTTAAAATCATCAGAAAGGAAAAACAAACTCTATATTGTTC AGCATGCAATACATACCACGCTAGGGCTGGCTCAATTGAAAGTGGGCAAAAGCTTACAAATACTAAAAAGAAGTGCTGCCGCGCAGTGTGGAGGCCACTG TTTGGAAATAAATCTTCCTAACACTACGACTTTTCATGTTTTGGAGTGGACTTTTAAAAAAGTTTTCCAACCACAATGGAAACAGGTTGAACCACACTGC GCCTACACATCCATCCATACGTCAGCCATTATAATCAGATTCTCACTGGGGGAGGCATTTTCTTCCCAAAGGAGCTGTATGCAGTCATCACCCGGAACTA ATGGGAAAGTGTTCTTAAGCAGCAAGTGACTCTGGACCACCTCTCTCACACACTGACTCTTCCACAGCATCTTCACCTGCTTCTGTTTCACTTGAATTCA TACAGTAGGCCACCATTTTATAACAGGTCTTAGTGTAAATTCTTCCAGACCAAGTCTGAGATAGTCTTGGTTGTAAAGCAAGACCGTCACCCCTTCTCCC AAAGCCAACATTATAAAAAGATTCCATTGTCTCAAACACAAATGTTCCAGTCTTGAGCACTTCCCAGCCATGGTGACTCGGGCATATCCTGGCAGTTGGT GGATTTTGCCCTGTAACACAATCCTTGTGGATATGATTCAAAGGTGACTTTAATTCAGAGAATGTGTTTTCCTTTCTGTTTTAAAAATATTTGAATTAAG TGATGGAAATTCTTTTGTTAAACATCAAAAGCTTTCTCCTTGAAAAGATGCTTGGTGTATCTGAAAGTCACGTGGGACATTTGGTGCATTCAGAAGGTCA AATCATTCCTGACCTCTCCTCTTAGGACCCAGCATTAACTGCTGCGATACTCAAGGCTTCCTTAAAGGATCACAGCACTGGCGCCTAGTTTTACTGTCCA GCAACTTTATTAGTTGTGCTAGCTGAGAATTGGAATATAGAGTCCTTTGAATGTTACGATCTTGTTTTCAAAACCTGGAGTCAAACCAATTAAGTATGGA CTTAACAAAGACAATTGATGATGTGAAATGATACCACCTGTCAAGGGCATAGTTACCATGTGGATAGAAAGATGAGTCCACTGATTATCTTCAAATCCCA TGTATTCTCTCTAGCACGTTGCTTCTGACAGAAAGAATAACTCACAGATTTGAAGTTTGTTCCTTTCCCCTGATGAAGAGTAGATTGGCCAAAAGGTAGA TGACAGGAAGGAAGAGGAGCCAGAATGACCCACAGTGATCAGTTCAGCAGTGCAGAGCGGCAGTGCAGAGGCTCATGGAACTCACACGGAAAAAGGAAAC ACATGCTGCTTAAAATGCACGATAACTTAATTATCCAAATTACCATTCAATTCCGGTATTTTTGAGATGAAAGCATTTGAGCCAACACTAAATTGACCTT AATTAAGGAATGAGGTAGGAAGAGGCACTTTTAATCTGGAGGAAGAAATAAATGGAAGACTGTAATAGGAAAAATACAGGTCTAGGAAAAAAATAATTTT TTTCCTTTGATGCTGGCCAAGGACCCCTCTACATAATACAGTTCTCCTGCTGGAAAGCATCAGGGCAAACAGAGTTATTCCAAACTCTGCAACAGGGAAG ACTGTACTTTGACCTTCTTTTCCTGGGGAAAGGGAACAACTAGTAATCTTTAAATGTCAAAACTTTTCTTCTAAATAGTACATTCATTAACCAGTTTCTT CTGGTGGTGCAAAGAACACTCACCACAGTGAGCAATACCACTATTCAATTTCCCCTTTGGAGAGGTGACAGCGGGGTAGAATCACCTGGAGTCAGCTGCT AGTCTTTAACTGATGACAAGGCCTTGCAAATACCCCTGAGAACAATTTCACTCTGAGCTCACAGGGAAGCAGCAGTCTGGTGTGGGCTCCTGTGGTGTAA CCATCAAATGTGGAAGACCTGATGGTGTTAGTGTGTGGGGATGCCGGGCTGAAATTCAACAGCCTTGCAAAAAGAAAGGGAAGATGGGATGTGTTAATAT TGTAGTGGCATGCACTTTCCAGCTCTCCATGGAGCTCTCTTTATATATGAGGTAATTGAATGTCACTATTCTGTACCATACAGCAGGTATTATCTAGCCA AGGTTATAATTACCATGAAGTGCTGTGGAATGTAGTAGGAGGCTTTTCACTGGG

BID.F1 (forward primer)
BID.R1 (reverse primer)
Mutually exclusive exon skipping

Frame 0

EGGSARGAIRRKRVVDRVRAPGRRCLGPDAPAP PRLEGGQQRFQPQG*VHHKPTGVWLPPKLF*QQL PQRAGRTGPRAASAGSPVGGLR*AAD*WQPQQP LPLGKNRDSESQEDIIRNIARHLAQVGDSMDRS IPPGLVNGLALQLRNTSRSEEDRNRDLATALEQL LQAYPRDMEKEKTMLVLALLLAKKVASHTPSLL RDVFHTTVNFINQNLRTYVRSLARNGMD*TDSS RSVTG*SSMWSQLYSCFQCRRSPGMSTAFLEKTG WKIAVTSILKTMLNL*PTLKYLH*YT*MKMSIY TYLNGLHIIHT*ICTSVNLHTVPLFPLCRFPLK N*IGKQVSRK*KQNTIFLVKKNYCLLKYNHRGWS YSRQYPV*GKQESEKEHTPYK*KIPLKIGTIYL NTKEPTIFLFKKPHGTEILN*SAALK*WEVRPQ YTGA*LFQLRFLCWSQKEPLVVLKGVKVI*GPRS ATVCLQNQVTNCIHFFSFHDIKTLLKT*SHGCQ KLLRCPGS*PPGNSCKLPISSHTLSSSMPQKCI WREQVSKHKR*KSSWTF*KFSKVVPSLRDSQNQV T*VVPK*IRKSLALETVQHWSAVPVVSYVPGIS LKARQWMLGPYHTHCCEQETPVTTT*GHWRRI* VRALTDS*FLLTRCFPVL*EFKIIRKEKQTLYCS ACNTYHARAGSIESGQKLTNTKKKCCRAVWRPL FGNKSS*HYDFSCFGVDF*KSFPTTMETG*TTL RLHIHPYVSHYNQILTGGGIFFPKELYAVITRN* WESVLKQQVTLDHLSHTLTLPQHLHLLLFHLNS YSRPPFYNRS*CKFFQTKSEIVLVVKQDRHPFS QSQHYKKIPLSQTQMFQS*ALPSHGDSGISWQLV DFAL*HNPCGYDSKVTLIQRMCFPFCFKNI*IK *WKFFC*TSKAFSLKRCLVYLKVTWDIWCIQKV KSFLTSPLRTQH*LLRYSRLP*RITALAPSFTVQ QLY*LC*LRIGI*SPLNVTILFSKPGVKPIKYG LNKDN**CEMIPPVKGIVTMWIER*VH*LSSNP MYSL*HVASDRKNNSQI*SLFLSPDEE*IGQKVD DRKEEEPE*PTVISSAVQSGSAEAHGTHTEKGN TCCLKCTIT*LSKLPFNSGIFEMKAFEPTLN*P *LRNEVGRGTFNLEEEINGRL**EKYRSRKKIIF FL*CWPRTPLHNTVLLLESIRANRVIPNSATGK TVL*PSFPGEREQLVIFKCQNFSSK*YIH*PVS SGGAKNTHHSEQYHYSISPLER*QRGRITWSQLL VFN**QGLANTPENNFTLSSQGSSSLVWAPVV* PSNVEDLMVLVCGDAGLKFNSLAKRKGRWDVLI L*WHALSSSPWSSLYI*GN*MSLFCTIQQVLSSQ GYNYHEVLWNVVGGFSL

Frame 1

KEEARGAP*GGSG*STVSARLGDAASARTRPRP RGWRVVNNGSSLRDECITNLLVFGFLQSCSDNS FRRELDALGHELPVLAPQWEGYDELQTDGNRSSH SRLGRIEILKVKKTSSGILPGTSPRSGTAWTVA SLRAW*TAWPCSSGTPAGRRRTGTGTWPLPWSS CCRPTLETWRRRRPCWCWPCCWPRRWPVTRRPCS VMSFTQQ*ILLTRTYAPT*GA*PEMGWTERTVP EV*LAKARCGHSCIAASSVDGALACQQRS*RRQ AGR*L*LLF*RQC*TYNPL*NIYINILE*KCPFT RI*MAFISSTHESAHL*IYTRCLYFHCAGSHLK IKLESRFQGSRNKIQFFW*KKITVY*STTIEDG LTAGSILFEESKNQRRNIPLTNEKFHSK*GLSIL ILRNQQSSCLKNHMAQRF*TKVLHSNDGKSGPS TQGLDFFNFVSFVGVKKNHLWF*KV*R*FKGPG QPLFVYKIR*LTAYTFSLSMTSRLC*RHEATGAR SYCDAPGVSPLVIAVNFQFLAIRSAHPCLRSAS GENRFLSIKDERAVGLFKNSAKWFPLLGTVKTK SLR*YQNK*GKA*L*KQCNTGLLFQW*AMSQESV *KHDSGCWVHITHIAVNRKLL*PQHEATGDAYE *GH*RTHDFFLPDAFLFFKSLKSSERKNKLYIV QHAIHTTLGLAQLKVGKSLQILKRSAAAQCGGHC LEINLPNTTTFHVLEWTFKKVFQPQWKQVEPHC AYTSIHTSAIIIRFSLGEAFSSQRSCMQSSPGT NGKVFLSSK*LWTTSLTH*LFHSIFTCFCFT*IH TVGHHFITGLSVNSSRPSLR*SWL*SKTVTPSP KANIIKRFHCLKHKCSSLEHFPAMVTRAYPGSW WILPCNTILVDMIQR*L*FRECVFLSVLKIFELS DGNSFVKHQKLSP*KDAWCI*KSRGTFGAFRRS NHS*PLLLGPSINCCDTQGFLKGSQHWRLVLLS SNFISCAS*ELEYRVL*MLRSCFQNLESNQLSMD LTKTIDDVK*YHLSRA*LPCG*KDESTDYLQIP CILSSTLLLTERITHRFEVCSFPLMKSRLAKR* MTGRKRSQNDPQ*SVQQCRAAVQRLMELTRKKET HAA*NAR*LNYPNYHSIPVFLR*KHLSQH*IDL N*GMR*EEALLIWRKK*MEDCNRKNTGLGKK*F FSFDAGQGPLYIIQFSCWKASGQTELFQTLQQGR LYFDLLFLGKGNN**SLNVKTFLLNSTFINQFL LVVQRTLTTVSNTTIQFPLWRGDSGVESPGVSC *SLTDDKALQIPLRTISL*AHREAAVWCGLLWCN HQMWKT*WC*CVGMPG*NSTALQKEREDGMC*Y CSGMHFPALHGALFIYEVIECHYSVPYSRYYLA KVIITMKCCGM**EAFHW

Frame 2

RRKRAGRHKEEAGSRPCPRAWETLPRPGRARAP AAGGWSTTVPASGMSASQTYWCLASSKAVLTTA SAESWTHWATSCQCWLPSGRATMSCRLMATAAA TPAWEE*RF*KSRRHHPEYCQAPRPGRGQHGP*H PSGPGERPGPAAQEHQPVGGGPEQGPGHCPGAA AAGLP*RHGEGEDHAGAGPAAGQEGGQSHAVLA P*CLSHNSEFY*PEPTHLREELSQKWDGLNGQFQ KCDWLKLDVVTAV*LLPV*TEPWHVNSVPREDR LEDSCDFYFKDNVKLITHFKISTLIYLNENVHL HVFEWPSYHPHMNLHICKSTHGAFISTVQVPT*K LNWKAGFKEVETKYNFFGKKKLLFIKVQP*RMV LQQAVSCLRKARIREGTYPLQMKNSTQNRDYLS *Y*GTNNLPV*KTTWHRDSELKCCTQMMGSPAPV HRGLTFSTSFPLLESKRTTCGSKRCEGDLRAQV SHCLFTKSGN*LHTLFLFP*HQDFAKDMKPRVP EATAMPRELAPW**L*TSNF*PYAQLIHASEVHL ERTGF*A*KMKEQLDFLKIQQSGSLS*GQSKPS HLGSTKINKEKLSFRNSATLVCCSSGKLCPRNQ FKSTTVDAGSISHTLL*TGNSCDHNMRPLETHMS KGTDGLMISSYQMLSCSLRV*NHQKGKTNSILF SMQYIPR*GWLN*KWAKAYKY*KEVLPRSVEAT VWK*IFLTLRLFMFWSGLLKKFSNHNGNRLNHTA PTHPSIRQPL*SDSHWGRHFLPKGAVCSHHPEL MGKCS*AASDSGPPLSHTDSSTASSPASVSLEF IQ*ATIL*QVLV*ILPDQV*DSLGCKARPSPLLP KPTL*KDSIVSNTNVPVLSTSQPW*LGHILAVG GFCPVTQSLWI*FKGDFNSENVFSFLF*KYLN* VMEILLLNIKSFLLEKMLGVSESHVGHLVHSEGQ IIPDLSS*DPALTAAILKASLKDHSTGA*FYCP ATLLVVLAENWNIESFECYDLVFKTWSQTN*VW T*QRQLMM*NDTTCQGHSYHVDRKMSPLIIFKSH VFSLARCF*QKE*LTDLKFVPFP**RVDWPKGR *QEGRGARMTHSDQFSSAERQCRGSWNSHGKRK HMLLKMHDNLIIQITIQFRYF*DESI*ANTKLTL IKE*GRKRHF*SGGRNKWKTVIGKIQV*EKNNF FPLMLAKDPST*YSSPAGKHQGKQSYSKLCNRE DCTLTFFSWGKGTTSNL*MSKLFF*IVHSLTSFF WWCKEHSPQ*AIPLFNFPFGEVTAG*NHLESAA SL*LMTRPCKYP*EQFHSELTGKQQSGVGSCGV TIKCGRPDGVSVWGCRAEIQQPCKKKGKMGCVNI VVACTFQLSMELSLYMR*LNVTILYHTAGII*P RL*LP*SAVECSRRLFTG