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Sequences

Sequence BID.jAug05

GAAGGAGGAAGCGCGCGGGGCGCCATAAGGAGGAAGCGGGTAGTCGACCGTGTCCGCGCGCCTGGGAGACGCTGCCTCGGCCCGGACGCGCCCGCGCCCC CGCGGCTGGAGGGTGGTCGCCACTGGGACACTGTGAACCAGGAGTGAGTCGGAGCTGCCGCGCTGCCCAGGCCATGGACTGTGAGATTCTGAAAGTCAAG AAGACATCATCCGGAATATTGCCAGGCACCTCGCCCAGGTCGGGGACAGCATGGACCGTAGCATCCCTCCGGGCCTGGTGAACGGCCTGGCCCTGCAGCT CAGGAACACCAGCCGGTCGGAGGAGGACCGGAACAGGGACCTGGCCACTGCCCTGGAGCAGCTGCTGCAGGCCTACCCTAGAGACATGGAGAAGGAGAAG ACCATGCTGGTGCTGGCCCTGCTGCTGGCCAAGAAGGTGGCCAGTCACACGCCGTCCTTGCTCCGTGATGTCTTTCACACAACAGTGAATTTTATTAACC AGAACCTACGCACCTACGTGAGGAGCTTAGCCAGAAATGGGATGGACTGAACGGACAGTTCCAGAAGTGTGACTGGCTAAAGCTCGATGTGGTCACAGCT GTATAGCTGCTTCCAGTGTAGACGGAGCCCTGGCATGTCAACAGCGTTCCTAGAGAAGACAGGCTGGAAGATAGCTGTGACTTCTATTTTAAAGACAATG TTAAACTTATAACCCACTTTAAAATATCTACATTAATATACTTGAATGAAAATGTCCATATCACACACATTGCTGTGAACAGGAAACTCCTGTGACCACA ACATGAGGCCACTGGAGACGCATATGAGTAAGGGCACTGACGGACTCATGATTTCTTCTTACCAGATGCTTTCCTGTTCTTTAAGAGTTTAAAATCATCA GAAAGGAAAAACAAACTCTATATTGTTCAGCATGCAATACATACCACGCTAGGGCTGGCTCAATTGAAAGTGGGCAAAAGCTTACAAATACTAAAAAGAA GTGCTGCCGCGCAGTGTGGAGGCCACTGTTTGGAAATAAATCTTCCTAACACTACGACTTTTCATGTTTTGGAGTGGACTTTTAAAAAAGTTTTCCAACC ACAATGGAAACAGGTTGAACCACACTGCGCCTACACATCCATCCATACGTCAGCCATTATAATCAGATTCTCACTGGGGGAGGCATTTTCTTCCCAAAGG AGCTGTATGCAGTCATCACCCGGAACTAATGGGAAAGTGTTCTTAAGCAGCAAGTGACTCTGGACCACCTCTCTCACACACTGACTCTTCCACAGCATCT TCACCTGCTTCTGTTTCACTTGAATTCATACAGTAGGCCACCATTTTATAACAGGTCTTAGTGTAAATTCTTCCAGACCAAGTCTGAGATAGTCTTGGTT GTAAAGCAAGACCGTCACCCCTTCTCCCAAAGCCAACATTATAAAAAGATTCCATTGTCTCAAACACAAATGTTCCAGTCTTGAGCACTTCCCAGCCATG GTGACTCGGGCATATCCTGGCAGTTGGTGGATTTTGCCCTGTAACACAATCCTTGTGGATATGATTCAAAGGTGACTTTAATTCAGAGAATGTGTTTTCC TTTCTGTTTTAAAAATATTTGAATTAAGTGATGGAAATTCTTTTGTTAAACATCAAAAGCTTTCTCCTTGAAAAGATGCTTGGTGTATCTGAAAGTCACG TGGGACATTTGGTGCATTCAGAAGGTCAAATCATTCCTGACCTCTCCTCTTAGGACCCAGCATTAACTGCTGCGATACTCAAGGCTTCCTTAAAGGATCA CAGCACTGGCGCCTAGTTTTACTGTCCAGCAACTTTATTAGTTGTGCTAGCTGAGAATTGGAATATAGAGTCCTTTGAATGTTACGATCTTGTTTTCAAA ACCTGGAGTCAAACCAATTAAGTATGGACTTAACAAAGACAATTGATGATGTGAAATGATACCACCTGTCAAGGGCATAGTTACCATGTGGATAGAAAGA TGAGTCCACTGATTATCTTCAAATCCCATGTATTCTCTCTAGCACGTTGCTTCTGACAGAAAGAATAACTCACAGATTTGAAGTTTGTTCCTTTCCCCTG ATGAAGAGTAGATTGGCCAAAAGGTAGATGACAGGAAGGAAGAGGAGCCAGAATGACCCACAGTGATCAGTTCAGCAGTGCAGAGCGGCAGTGCAGAGGC TCATGGAACTCACACGGAAAAAGGAAACACATGCTGCTTAAAATGCACGATAACTTAATTATCCAAATTACCATTCAATTCCGGTATTTTTGAGATGAAA GCATTTGAGCCAACACTAAATTGACCTTAATTAAGGAATGAGGTAGGAAGAGGCACTTTTAATCTGGAGGAAGAAATAAATGGAAGACTGTAATAGGAAA AATACAGGTCTAGGAAAAAAATAATTTTTTTCCTTTGATGCTGGCCAAGGACCCCTCTACATAATACAGTTCTCCTGCTGGAAAGCATCAGGGCAAACAG AGTTATTCCAAACTCTGCAACAGGGAAGACTGTACTTTGACCTTCTTTTCCTGGGGAAAGGGAACAACTAGTAATCTTTAAATGTCAAAACTTTTCTTCT AAATAGTACATTCATTAACCAGTTTCTTCTGGTGGTGCAAAGAACACTCACCACAGTGAGCAATACCACTATTCAATTTCCCCTTTGGAGAGGTGACAGC GGGGTAGAATCACCTGGAGTCAGCTGCTAGTCTTTAACTGATGACAAGGCCTTGCAAATACCCCTGAGAACAATTTCACTCTGAGCTCACAGGGAAGCAG CAGTCTGGTGTGGGCTCCTGTGGTGTAACCATCAAATGTGGAAGACCTGATGGTGTTAGTGTGTGGGGATGCCGGGCTGAAATTCAACAGCCTTGCAAAA AGAAAGGGAAGATGGGATGTGTTAATATTGTAGTGGCATGCACTTTCCAGCTCTCCATGGAGCTCTCTTTATATATGAGGTAATTGAATGTCACTATTCT GTACCATACAGCAGGTATTATCTAGCCAAGGTTATAATTACCATGAAGTGCTGTGGAATGTAGTAGGAGGCTTTTCACTGGG

BID.F1 (forward primer)
BID.R1 (reverse primer)
Single exon skipping

Frame 0

EGGSARGAIRRKRVVDRVRAPGRRCLGPDAPAP PRLEGGRHWDTVNQE*VGAAALPRPWTVRF*KSR RHHPEYCQAPRPGRGQHGP*HPSGPGERPGPAA QEHQPVGGGPEQGPGHCPGAAAAGLP*RHGEGE DHAGAGPAAGQEGGQSHAVLAP*CLSHNSEFY*P EPTHLREELSQKWDGLNGQFQKCDWLKLDVVTA V*LLPV*TEPWHVNSVPREDRLEDSCDFYFKDN VKLITHFKISTLIYLNENVHITHIAVNRKLL*PQ HEATGDAYE*GH*RTHDFFLPDAFLFFKSLKSS ERKNKLYIVQHAIHTTLGLAQLKVGKSLQILKR SAAAQCGGHCLEINLPNTTTFHVLEWTFKKVFQP QWKQVEPHCAYTSIHTSAIIIRFSLGEAFSSQR SCMQSSPGTNGKVFLSSK*LWTTSLTH*LFHSI FTCFCFT*IHTVGHHFITGLSVNSSRPSLR*SWL *SKTVTPSPKANIIKRFHCLKHKCSSLEHFPAM VTRAYPGSWWILPCNTILVDMIQR*L*FRECVF LSVLKIFELSDGNSFVKHQKLSP*KDAWCI*KSR GTFGAFRRSNHS*PLLLGPSINCCDTQGFLKGS QHWRLVLLSSNFISCAS*ELEYRVL*MLRSCFQ NLESNQLSMDLTKTIDDVK*YHLSRA*LPCG*KD ESTDYLQIPCILSSTLLLTERITHRFEVCSFPL MKSRLAKR*MTGRKRSQNDPQ*SVQQCRAAVQR LMELTRKKETHAA*NAR*LNYPNYHSIPVFLR*K HLSQH*IDLN*GMR*EEALLIWRKK*MEDCNRK NTGLGKK*FFSFDAGQGPLYIIQFSCWKASGQT ELFQTLQQGRLYFDLLFLGKGNN**SLNVKTFLL NSTFINQFLLVVQRTLTTVSNTTIQFPLWRGDS GVESPGVSC*SLTDDKALQIPLRTISL*AHREA AVWCGLLWCNHQMWKT*WC*CVGMPG*NSTALQK EREDGMC*YCSGMHFPALHGALFIYEVIECHYS VPYSRYYLAKVIITMKCCGM**EAFHW

Frame 1

KEEARGAP*GGSG*STVSARLGDAASARTRPRP RGWRVVATGTL*TRSESELPRCPGHGL*DSESQ EDIIRNIARHLAQVGDSMDRSIPPGLVNGLALQL RNTSRSEEDRNRDLATALEQLLQAYPRDMEKEK TMLVLALLLAKKVASHTPSLLRDVFHTTVNFIN QNLRTYVRSLARNGMD*TDSSRSVTG*SSMWSQL YSCFQCRRSPGMSTAFLEKTGWKIAVTSILKTM LNL*PTLKYLH*YT*MKMSISHTLL*TGNSCDH NMRPLETHMSKGTDGLMISSYQMLSCSLRV*NHQ KGKTNSILFSMQYIPR*GWLN*KWAKAYKY*KE VLPRSVEATVWK*IFLTLRLFMFWSGLLKKFSN HNGNRLNHTAPTHPSIRQPL*SDSHWGRHFLPKG AVCSHHPELMGKCS*AASDSGPPLSHTDSSTAS SPASVSLEFIQ*ATIL*QVLV*ILPDQV*DSLG CKARPSPLLPKPTL*KDSIVSNTNVPVLSTSQPW *LGHILAVGGFCPVTQSLWI*FKGDFNSENVFS FLF*KYLN*VMEILLLNIKSFLLEKMLGVSESH VGHLVHSEGQIIPDLSS*DPALTAAILKASLKDH STGA*FYCPATLLVVLAENWNIESFECYDLVFK TWSQTN*VWT*QRQLMM*NDTTCQGHSYHVDRK MSPLIIFKSHVFSLARCF*QKE*LTDLKFVPFP* *RVDWPKGR*QEGRGARMTHSDQFSSAERQCRG SWNSHGKRKHMLLKMHDNLIIQITIQFRYF*DE SI*ANTKLTLIKE*GRKRHF*SGGRNKWKTVIGK IQV*EKNNFFPLMLAKDPST*YSSPAGKHQGKQ SYSKLCNREDCTLTFFSWGKGTTSNL*MSKLFF *IVHSLTSFFWWCKEHSPQ*AIPLFNFPFGEVTA G*NHLESAASL*LMTRPCKYP*EQFHSELTGKQ QSGVGSCGVTIKCGRPDGVSVWGCRAEIQQPCK KKGKMGCVNIVVACTFQLSMELSLYMR*LNVTIL YHTAGII*PRL*LP*SAVECSRRLFTG

Frame 2

RRKRAGRHKEEAGSRPCPRAWETLPRPGRARAP AAGGWSPLGHCEPGVSRSCRAAQAMDCEILKVK KTSSGILPGTSPRSGTAWTVASLRAW*TAWPCS SGTPAGRRRTGTGTWPLPWSSCCRPTLETWRRRR PCWCWPCCWPRRWPVTRRPCSVMSFTQQ*ILLT RTYAPT*GA*PEMGWTERTVPEV*LAKARCGHS CIAASSVDGALACQQRS*RRQAGR*L*LLF*RQC *TYNPL*NIYINILE*KCPYHTHCCEQETPVTT T*GHWRRI*VRALTDS*FLLTRCFPVL*EFKII RKEKQTLYCSACNTYHARAGSIESGQKLTNTKKK CCRAVWRPLFGNKSS*HYDFSCFGVDF*KSFPT TMETG*TTLRLHIHPYVSHYNQILTGGGIFFPK ELYAVITRN*WESVLKQQVTLDHLSHTLTLPQHL HLLLFHLNSYSRPPFYNRS*CKFFQTKSEIVLV VKQDRHPFSQSQHYKKIPLSQTQMFQS*ALPSH GDSGISWQLVDFAL*HNPCGYDSKVTLIQRMCFP FCFKNI*IK*WKFFC*TSKAFSLKRCLVYLKVT WDIWCIQKVKSFLTSPLRTQH*LLRYSRLP*RI TALAPSFTVQQLY*LC*LRIGI*SPLNVTILFSK PGVKPIKYGLNKDN**CEMIPPVKGIVTMWIER *VH*LSSNPMYSL*HVASDRKNNSQI*SLFLSP DEE*IGQKVDDRKEEEPE*PTVISSAVQSGSAEA HGTHTEKGNTCCLKCTIT*LSKLPFNSGIFEMK AFEPTLN*P*LRNEVGRGTFNLEEEINGRL**E KYRSRKKIIFFL*CWPRTPLHNTVLLLESIRANR VIPNSATGKTVL*PSFPGEREQLVIFKCQNFSS K*YIH*PVSSGGAKNTHHSEQYHYSISPLER*Q RGRITWSQLLVFN**QGLANTPENNFTLSSQGSS SLVWAPVV*PSNVEDLMVLVCGDAGLKFNSLAK RKGRWDVLIL*WHALSSSPWSSLYI*GN*MSLF CTIQQVLSSQGYNYHEVLWNVVGGFSL

Sequence BID.cAug05

GAAGGAGGAAGCGCGCGGGGCGCCATAAGGAGGAAGCGGGTAGTCGACCGTGTCCGCGCGCCTGGGAGACGCTGCCTCGGCCCGGACGCGCCCGCGCCCC CGCGGCTGGAGGGTGGTCGCCACTGGGACACTGTGAACCAGGAGTGAGTCGGAGCTGCCGCGCTGCCCAGGCCATGGACTGTGAGGTCAACAACGGTTCC AGCCTCAGGGATGAGTGCATCACAAACCTACTGGTGTTTGGCTTCCTCCAAAGCTGTTCTGACAACAGCTTCCGCAGAGAGCTGGACGCACTGGGCCACG AGCTGCCAGTGCTGGCTCCCCAGTGGGAGGGCTACGATGAGCTGCAGACTGATGGCAACCGCAGCAGCCACTCCCGCTTGGGAAGAATAGAGGCAGATTC TGAAAGTCAAGAAGACATCATCCGGAATATTGCCAGGCACCTCGCCCAGGTCGGGGACAGCATGGACCGTAGCATCCCTCCGGGCCTGGTGAACGGCCTG GCCCTGCAGCTCAGGAACACCAGCCGGTCGGAGGAGGACCGGAACAGGGACCTGGCCACTGCCCTGGAGCAGCTGCTGCAGGCCTACCCTAGAGACATGG AGAAGGAGAAGACCATGCTGGTGCTGGCCCTGCTGCTGGCCAAGAAGGTGGCCAGTCACACGCCGTCCTTGCTCCGTGATGTCTTTCACACAACAGTGAA TTTTATTAACCAGAACCTACGCACCTACGTGAGGAGCTTAGCCAGAAATGGGATGGACTGAACGGACAGTTCCAGAAGTGTGACTGGCTAAAGCTCGATG TGGTCACAGCTGTATAGCTGCTTCCAGTGTAGACGGAGCCCTGGCATGTCAACAGCGTTCCTAGAGAAGACAGGCTGGAAGATAGCTGTGACTTCTATTT TAAAGACAATGTTAAACTTATAACCCACTTTAAAATATCTACATTAATATACTTGAATGAAAATGTCCATATCACACACATTGCTGTGAACAGGAAACTC CTGTGACCACAACATGAGGCCACTGGAGACGCATATGAGTAAGGGCACTGACGGACTCATGATTTCTTCTTACCAGATGCTTTCCTGTTCTTTAAGAGTT TAAAATCATCAGAAAGGAAAAACAAACTCTATATTGTTCAGCATGCAATACATACCACGCTAGGGCTGGCTCAATTGAAAGTGGGCAAAAGCTTACAAAT ACTAAAAAGAAGTGCTGCCGCGCAGTGTGGAGGCCACTGTTTGGAAATAAATCTTCCTAACACTACGACTTTTCATGTTTTGGAGTGGACTTTTAAAAAA GTTTTCCAACCACAATGGAAACAGGTTGAACCACACTGCGCCTACACATCCATCCATACGTCAGCCATTATAATCAGATTCTCACTGGGGGAGGCATTTT CTTCCCAAAGGAGCTGTATGCAGTCATCACCCGGAACTAATGGGAAAGTGTTCTTAAGCAGCAAGTGACTCTGGACCACCTCTCTCACACACTGACTCTT CCACAGCATCTTCACCTGCTTCTGTTTCACTTGAATTCATACAGTAGGCCACCATTTTATAACAGGTCTTAGTGTAAATTCTTCCAGACCAAGTCTGAGA TAGTCTTGGTTGTAAAGCAAGACCGTCACCCCTTCTCCCAAAGCCAACATTATAAAAAGATTCCATTGTCTCAAACACAAATGTTCCAGTCTTGAGCACT TCCCAGCCATGGTGACTCGGGCATATCCTGGCAGTTGGTGGATTTTGCCCTGTAACACAATCCTTGTGGATATGATTCAAAGGTGACTTTAATTCAGAGA ATGTGTTTTCCTTTCTGTTTTAAAAATATTTGAATTAAGTGATGGAAATTCTTTTGTTAAACATCAAAAGCTTTCTCCTTGAAAAGATGCTTGGTGTATC TGAAAGTCACGTGGGACATTTGGTGCATTCAGAAGGTCAAATCATTCCTGACCTCTCCTCTTAGGACCCAGCATTAACTGCTGCGATACTCAAGGCTTCC TTAAAGGATCACAGCACTGGCGCCTAGTTTTACTGTCCAGCAACTTTATTAGTTGTGCTAGCTGAGAATTGGAATATAGAGTCCTTTGAATGTTACGATC TTGTTTTCAAAACCTGGAGTCAAACCAATTAAGTATGGACTTAACAAAGACAATTGATGATGTGAAATGATACCACCTGTCAAGGGCATAGTTACCATGT GGATAGAAAGATGAGTCCACTGATTATCTTCAAATCCCATGTATTCTCTCTAGCACGTTGCTTCTGACAGAAAGAATAACTCACAGATTTGAAGTTTGTT CCTTTCCCCTGATGAAGAGTAGATTGGCCAAAAGGTAGATGACAGGAAGGAAGAGGAGCCAGAATGACCCACAGTGATCAGTTCAGCAGTGCAGAGCGGC AGTGCAGAGGCTCATGGAACTCACACGGAAAAAGGAAACACATGCTGCTTAAAATGCACGATAACTTAATTATCCAAATTACCATTCAATTCCGGTATTT TTGAGATGAAAGCATTTGAGCCAACACTAAATTGACCTTAATTAAGGAATGAGGTAGGAAGAGGCACTTTTAATCTGGAGGAAGAAATAAATGGAAGACT GTAATAGGAAAAATACAGGTCTAGGAAAAAAATAATTTTTTTCCTTTGATGCTGGCCAAGGACCCCTCTACATAATACAGTTCTCCTGCTGGAAAGCATC AGGGCAAACAGAGTTATTCCAAACTCTGCAACAGGGAAGACTGTACTTTGACCTTCTTTTCCTGGGGAAAGGGAACAACTAGTAATCTTTAAATGTCAAA ACTTTTCTTCTAAATAGTACATTCATTAACCAGTTTCTTCTGGTGGTGCAAAGAACACTCACCACAGTGAGCAATACCACTATTCAATTTCCCCTTTGGA GAGGTGACAGCGGGGTAGAATCACCTGGAGTCAGCTGCTAGTCTTTAACTGATGACAAGGCCTTGCAAATACCCCTGAGAACAATTTCACTCTGAGCTCA CAGGGAAGCAGCAGTCTGGTGTGGGCTCCTGTGGTGTAACCATCAAATGTGGAAGACCTGATGGTGTTAGTGTGTGGGGATGCCGGGCTGAAATTCAACA GCCTTGCAAAAAGAAAGGGAAGATGGGATGTGTTAATATTGTAGTGGCATGCACTTTCCAGCTCTCCATGGAGCTCTCTTTATATATGAGGTAATTGAAT GTCACTATTCTGTACCATACAGCAGGTATTATCTAGCCAAGGTTATAATTACCATGAAGTGCTGTGGAATGTAGTAGGAGGCTTTTCACTGGG

BID.F1 (forward primer)
BID.R1 (reverse primer)
Single exon skipping

Frame 0

EGGSARGAIRRKRVVDRVRAPGRRCLGPDAPAP PRLEGGRHWDTVNQE*VGAAALPRPWTVRSTTVP ASGMSASQTYWCLASSKAVLTTASAESWTHWAT SCQCWLPSGRATMSCRLMATAAATPAWEE*RQI LKVKKTSSGILPGTSPRSGTAWTVASLRAW*TAW PCSSGTPAGRRRTGTGTWPLPWSSCCRPTLETW RRRRPCWCWPCCWPRRWPVTRRPCSVMSFTQQ* ILLTRTYAPT*GA*PEMGWTERTVPEV*LAKARC GHSCIAASSVDGALACQQRS*RRQAGR*L*LLF *RQC*TYNPL*NIYINILE*KCPYHTHCCEQET PVTTT*GHWRRI*VRALTDS*FLLTRCFPVL*EF KIIRKEKQTLYCSACNTYHARAGSIESGQKLTN TKKKCCRAVWRPLFGNKSS*HYDFSCFGVDF*K SFPTTMETG*TTLRLHIHPYVSHYNQILTGGGIF FPKELYAVITRN*WESVLKQQVTLDHLSHTLTL PQHLHLLLFHLNSYSRPPFYNRS*CKFFQTKSE IVLVVKQDRHPFSQSQHYKKIPLSQTQMFQS*AL PSHGDSGISWQLVDFAL*HNPCGYDSKVTLIQR MCFPFCFKNI*IK*WKFFC*TSKAFSLKRCLVY LKVTWDIWCIQKVKSFLTSPLRTQH*LLRYSRLP *RITALAPSFTVQQLY*LC*LRIGI*SPLNVTI LFSKPGVKPIKYGLNKDN**CEMIPPVKGIVTM WIER*VH*LSSNPMYSL*HVASDRKNNSQI*SLF LSPDEE*IGQKVDDRKEEEPE*PTVISSAVQSG SAEAHGTHTEKGNTCCLKCTIT*LSKLPFNSGI FEMKAFEPTLN*P*LRNEVGRGTFNLEEEINGRL **EKYRSRKKIIFFL*CWPRTPLHNTVLLLESI RANRVIPNSATGKTVL*PSFPGEREQLVIFKCQ NFSSK*YIH*PVSSGGAKNTHHSEQYHYSISPLE R*QRGRITWSQLLVFN**QGLANTPENNFTLSS QGSSSLVWAPVV*PSNVEDLMVLVCGDAGLKFN SLAKRKGRWDVLIL*WHALSSSPWSSLYI*GN*M SLFCTIQQVLSSQGYNYHEVLWNVVGGFSL

Frame 1

KEEARGAP*GGSG*STVSARLGDAASARTRPRP RGWRVVATGTL*TRSESELPRCPGHGL*GQQRF QPQG*VHHKPTGVWLPPKLF*QQLPQRAGRTGPR AASAGSPVGGLR*AAD*WQPQQPLPLGKNRGRF *KSRRHHPEYCQAPRPGRGQHGP*HPSGPGERP GPAAQEHQPVGGGPEQGPGHCPGAAAAGLP*RHG EGEDHAGAGPAAGQEGGQSHAVLAP*CLSHNSE FY*PEPTHLREELSQKWDGLNGQFQKCDWLKLD VVTAV*LLPV*TEPWHVNSVPREDRLEDSCDFYF KDNVKLITHFKISTLIYLNENVHITHIAVNRKL L*PQHEATGDAYE*GH*RTHDFFLPDAFLFFKS LKSSERKNKLYIVQHAIHTTLGLAQLKVGKSLQI LKRSAAAQCGGHCLEINLPNTTTFHVLEWTFKK VFQPQWKQVEPHCAYTSIHTSAIIIRFSLGEAF SSQRSCMQSSPGTNGKVFLSSK*LWTTSLTH*LF HSIFTCFCFT*IHTVGHHFITGLSVNSSRPSLR *SWL*SKTVTPSPKANIIKRFHCLKHKCSSLEH FPAMVTRAYPGSWWILPCNTILVDMIQR*L*FRE CVFLSVLKIFELSDGNSFVKHQKLSP*KDAWCI *KSRGTFGAFRRSNHS*PLLLGPSINCCDTQGF LKGSQHWRLVLLSSNFISCAS*ELEYRVL*MLRS CFQNLESNQLSMDLTKTIDDVK*YHLSRA*LPC G*KDESTDYLQIPCILSSTLLLTERITHRFEVC SFPLMKSRLAKR*MTGRKRSQNDPQ*SVQQCRAA VQRLMELTRKKETHAA*NAR*LNYPNYHSIPVF LR*KHLSQH*IDLN*GMR*EEALLIWRKK*MED CNRKNTGLGKK*FFSFDAGQGPLYIIQFSCWKAS GQTELFQTLQQGRLYFDLLFLGKGNN**SLNVK TFLLNSTFINQFLLVVQRTLTTVSNTTIQFPLW RGDSGVESPGVSC*SLTDDKALQIPLRTISL*AH REAAVWCGLLWCNHQMWKT*WC*CVGMPG*NST ALQKEREDGMC*YCSGMHFPALHGALFIYEVIE CHYSVPYSRYYLAKVIITMKCCGM**EAFHW

Frame 2

RRKRAGRHKEEAGSRPCPRAWETLPRPGRARAP AAGGWSPLGHCEPGVSRSCRAAQAMDCEVNNGS SLRDECITNLLVFGFLQSCSDNSFRRELDALGH ELPVLAPQWEGYDELQTDGNRSSHSRLGRIEADS ESQEDIIRNIARHLAQVGDSMDRSIPPGLVNGL ALQLRNTSRSEEDRNRDLATALEQLLQAYPRDM EKEKTMLVLALLLAKKVASHTPSLLRDVFHTTVN FINQNLRTYVRSLARNGMD*TDSSRSVTG*SSM WSQLYSCFQCRRSPGMSTAFLEKTGWKIAVTSI LKTMLNL*PTLKYLH*YT*MKMSISHTLL*TGNS CDHNMRPLETHMSKGTDGLMISSYQMLSCSLRV *NHQKGKTNSILFSMQYIPR*GWLN*KWAKAYK Y*KEVLPRSVEATVWK*IFLTLRLFMFWSGLLKK FSNHNGNRLNHTAPTHPSIRQPL*SDSHWGRHF LPKGAVCSHHPELMGKCS*AASDSGPPLSHTDS STASSPASVSLEFIQ*ATIL*QVLV*ILPDQV*D SLGCKARPSPLLPKPTL*KDSIVSNTNVPVLST SQPW*LGHILAVGGFCPVTQSLWI*FKGDFNSE NVFSFLF*KYLN*VMEILLLNIKSFLLEKMLGVS ESHVGHLVHSEGQIIPDLSS*DPALTAAILKAS LKDHSTGA*FYCPATLLVVLAENWNIESFECYD LVFKTWSQTN*VWT*QRQLMM*NDTTCQGHSYHV DRKMSPLIIFKSHVFSLARCF*QKE*LTDLKFV PFP**RVDWPKGR*QEGRGARMTHSDQFSSAER QCRGSWNSHGKRKHMLLKMHDNLIIQITIQFRYF *DESI*ANTKLTLIKE*GRKRHF*SGGRNKWKT VIGKIQV*EKNNFFPLMLAKDPST*YSSPAGKH QGKQSYSKLCNREDCTLTFFSWGKGTTSNL*MSK LFF*IVHSLTSFFWWCKEHSPQ*AIPLFNFPFG EVTAG*NHLESAASL*LMTRPCKYP*EQFHSEL TGKQQSGVGSCGVTIKCGRPDGVSVWGCRAEIQQ PCKKKGKMGCVNIVVACTFQLSMELSLYMR*LN VTILYHTAGII*PRL*LP*SAVECSRRLFTG

Sequence BID.bAug05

GAAGGAGGAAGCGCGCGGGGCGCCATAAGGAGGAAGCGGGTAGTCGACCGTGTCCGCGCGCCTGGGAGACGCTGCCTCGGCCCGGACGCGCCCGCGCCCC CGCGGCTGGAGGGTGGTCGCCACTGGGACACTGTGAACCAGGAGTGAGTCGGAGCTGCCGCGCTGCCCAGGCCATGGACTGTGAGGTCAACAACGGTTCC AGCCTCAGGGATGAGTGCATCACAAACCTACTGGTGTTTGGCTTCCTCCAAAGCTGTTCTGACAACAGCTTCCGCAGAGAGCTGGACGCACTGGGCCACG AGCTGCCAGTGCTGGCTCCCCAGTGGGAGGGCTACGATGAGCTGCAGACTGATGGCAACCGCAGCAGCCACTCCCGCTTGGGAAGAATAGAGGCAGATTC TGAAAGTCAAGAAGACATCATCCGGAATATTGCCAGGCACCTCGCCCAGGTCGGGGACAGCATGGACCGTAGCATCCCTCCGGGCCTGGTGAACGGCCTG GCCCTGCAGCTCAGGAACACCAGCCGGTCGGAGGAGGACCGGAACAGGGACCTGGCCACTGCCCTGGAGCAGCTGCTGCAGGCCTACCCTAGAGACATGG AGAAGGAGAAGACCATGCTGGTGCTGGCCCTGCTGCTGGCCAAGAAGGTGGCCAGTCACACGCCGTCCTTGCTCCGTGATGTCTTTCACACAACAGTGAA TTTTATTAACCAGAACCTACGCACCTACGTGAGGAGCTTAGCCAGAAATGGGATGGACTGAACGGACAGTTCCAGAAGTGTGACTGGCTAAAGCTCGATG TGGTCACAGCTGTATAGCTGCTTCCAGTGTAGACGGAGCCCTGGCATGTCAACAGCGTTCCTAGAGAAGACAGGCTGGAAGATAGCTGTGACTTCTATTT TAAAGACAATGTTAAACTTATAACCCACTTTAAAATATCTACATTAATATACTTGAATGAAAATGTCCATTTACACGTATTTGAATGGCCTTCATATCAT CCACACATGAATCTGCACATCTGTAAATCTACACACGGTGCCTTTATTTCCACTGTGCAGGTTCCCACTTAAAAATTAAATTGGAAAGCAGGTTTCAAGG AAGTAGAAACAAAATACAATTTTTTTGGTAAAAAAAAATTACTGTTTATTAAAGTACAACCATAGAGGATGGTCTTACAGCAGGCAGTATCCTGTTTGAG GAAAGCAAGAATCAGAGAAGGAACATACCCCTTACAAATGAAAAATTCCACTCAAAATAGGGACTATCTATCTTAATACTAAGGAACCAACAATCTTCCT GTTTAAAAAACCACATGGCACAGAGATTCTGAACTAAAGTGCTGCACTCAAATGATGGGAAGTCCGGCCCCAGTACACAGGGGCTTGACTTTTTCAACTT CGTTTCCTTTGTTGGAGTCAAAAAGAACCACTTGTGGTTCTAAAAGGTGTGAAGGTGATTTAAGGGCCCAGGTCAGCCACTGTTTGTTTACAAAATCAGG TAACTAACTGCATACACTTTTTCTCTTTCCATGACATCAAGACTTTGCTAAAGACATGAAGCCACGGGTGCCAGAAGCTACTGCGATGCCCCGGGAGTTA GCCCCCTGGTAATAGCTGTAAACTTCCAATTTCTAGCCATACGCTCAGCTCATCCATGCCTCAGAAGTGCATCTGGAGAGAACAGGTTTCTAAGCATAAA AGATGAAAGAGCAGTTGGACTTTTTAAAAATTCAGCAAAGTGGTTCCCTCTCTTAGGGACAGTCAAAACCAAGTCACTTAGGTAGTACCAAAATAAATAA GGAAAAGCTTAGCTTTAGAAACAGTGCAACACTGGTCTGCTGTTCCAGTGGTAAGCTATGTCCCAGGAATCAGTTTAAAAGCACGACAGTGGATGCTGGG TCCATATCACACACATTGCTGTGAACAGGAAACTCCTGTGACCACAACATGAGGCCACTGGAGACGCATATGAGTAAGGGCACTGACGGACTCATGATTT CTTCTTACCAGATGCTTTCCTGTTCTTTAAGAGTTTAAAATCATCAGAAAGGAAAAACAAACTCTATATTGTTCAGCATGCAATACATACCACGCTAGGG CTGGCTCAATTGAAAGTGGGCAAAAGCTTACAAATACTAAAAAGAAGTGCTGCCGCGCAGTGTGGAGGCCACTGTTTGGAAATAAATCTTCCTAACACTA CGACTTTTCATGTTTTGGAGTGGACTTTTAAAAAAGTTTTCCAACCACAATGGAAACAGGTTGAACCACACTGCGCCTACACATCCATCCATACGTCAGC CATTATAATCAGATTCTCACTGGGGGAGGCATTTTCTTCCCAAAGGAGCTGTATGCAGTCATCACCCGGAACTAATGGGAAAGTGTTCTTAAGCAGCAAG TGACTCTGGACCACCTCTCTCACACACTGACTCTTCCACAGCATCTTCACCTGCTTCTGTTTCACTTGAATTCATACAGTAGGCCACCATTTTATAACAG GTCTTAGTGTAAATTCTTCCAGACCAAGTCTGAGATAGTCTTGGTTGTAAAGCAAGACCGTCACCCCTTCTCCCAAAGCCAACATTATAAAAAGATTCCA TTGTCTCAAACACAAATGTTCCAGTCTTGAGCACTTCCCAGCCATGGTGACTCGGGCATATCCTGGCAGTTGGTGGATTTTGCCCTGTAACACAATCCTT GTGGATATGATTCAAAGGTGACTTTAATTCAGAGAATGTGTTTTCCTTTCTGTTTTAAAAATATTTGAATTAAGTGATGGAAATTCTTTTGTTAAACATC AAAAGCTTTCTCCTTGAAAAGATGCTTGGTGTATCTGAAAGTCACGTGGGACATTTGGTGCATTCAGAAGGTCAAATCATTCCTGACCTCTCCTCTTAGG ACCCAGCATTAACTGCTGCGATACTCAAGGCTTCCTTAAAGGATCACAGCACTGGCGCCTAGTTTTACTGTCCAGCAACTTTATTAGTTGTGCTAGCTGA GAATTGGAATATAGAGTCCTTTGAATGTTACGATCTTGTTTTCAAAACCTGGAGTCAAACCAATTAAGTATGGACTTAACAAAGACAATTGATGATGTGA AATGATACCACCTGTCAAGGGCATAGTTACCATGTGGATAGAAAGATGAGTCCACTGATTATCTTCAAATCCCATGTATTCTCTCTAGCACGTTGCTTCT GACAGAAAGAATAACTCACAGATTTGAAGTTTGTTCCTTTCCCCTGATGAAGAGTAGATTGGCCAAAAGGTAGATGACAGGAAGGAAGAGGAGCCAGAAT GACCCACAGTGATCAGTTCAGCAGTGCAGAGCGGCAGTGCAGAGGCTCATGGAACTCACACGGAAAAAGGAAACACATGCTGCTTAAAATGCACGATAAC TTAATTATCCAAATTACCATTCAATTCCGGTATTTTTGAGATGAAAGCATTTGAGCCAACACTAAATTGACCTTAATTAAGGAATGAGGTAGGAAGAGGC ACTTTTAATCTGGAGGAAGAAATAAATGGAAGACTGTAATAGGAAAAATACAGGTCTAGGAAAAAAATAATTTTTTTCCTTTGATGCTGGCCAAGGACCC CTCTACATAATACAGTTCTCCTGCTGGAAAGCATCAGGGCAAACAGAGTTATTCCAAACTCTGCAACAGGGAAGACTGTACTTTGACCTTCTTTTCCTGG GGAAAGGGAACAACTAGTAATCTTTAAATGTCAAAACTTTTCTTCTAAATAGTACATTCATTAACCAGTTTCTTCTGGTGGTGCAAAGAACACTCACCAC AGTGAGCAATACCACTATTCAATTTCCCCTTTGGAGAGGTGACAGCGGGGTAGAATCACCTGGAGTCAGCTGCTAGTCTTTAACTGATGACAAGGCCTTG CAAATACCCCTGAGAACAATTTCACTCTGAGCTCACAGGGAAGCAGCAGTCTGGTGTGGGCTCCTGTGGTGTAACCATCAAATGTGGAAGACCTGATGGT GTTAGTGTGTGGGGATGCCGGGCTGAAATTCAACAGCCTTGCAAAAAGAAAGGGAAGATGGGATGTGTTAATATTGTAGTGGCATGCACTTTCCAGCTCT CCATGGAGCTCTCTTTATATATGAGGTAATTGAATGTCACTATTCTGTACCATACAGCAGGTATTATCTAGCCAAGGTTATAATTACCATGAAGTGCTGT GGAATGTAGTAGGAGGCTTTTCACTGGG

BID.F1 (forward primer)
BID.R1 (reverse primer)
Single exon skipping

Frame 0

EGGSARGAIRRKRVVDRVRAPGRRCLGPDAPAP PRLEGGRHWDTVNQE*VGAAALPRPWTVRSTTVP ASGMSASQTYWCLASSKAVLTTASAESWTHWAT SCQCWLPSGRATMSCRLMATAAATPAWEE*RQI LKVKKTSSGILPGTSPRSGTAWTVASLRAW*TAW PCSSGTPAGRRRTGTGTWPLPWSSCCRPTLETW RRRRPCWCWPCCWPRRWPVTRRPCSVMSFTQQ* ILLTRTYAPT*GA*PEMGWTERTVPEV*LAKARC GHSCIAASSVDGALACQQRS*RRQAGR*L*LLF *RQC*TYNPL*NIYINILE*KCPFTRI*MAFIS STHESAHL*IYTRCLYFHCAGSHLKIKLESRFQG SRNKIQFFW*KKITVY*STTIEDGLTAGSILFE ESKNQRRNIPLTNEKFHSK*GLSILILRNQQSS CLKNHMAQRF*TKVLHSNDGKSGPSTQGLDFFNF VSFVGVKKNHLWF*KV*R*FKGPGQPLFVYKIR *LTAYTFSLSMTSRLC*RHEATGARSYCDAPGV SPLVIAVNFQFLAIRSAHPCLRSASGENRFLSIK DERAVGLFKNSAKWFPLLGTVKTKSLR*YQNK* GKA*L*KQCNTGLLFQW*AMSQESV*KHDSGCW VHITHIAVNRKLL*PQHEATGDAYE*GH*RTHDF FLPDAFLFFKSLKSSERKNKLYIVQHAIHTTLG LAQLKVGKSLQILKRSAAAQCGGHCLEINLPNT TTFHVLEWTFKKVFQPQWKQVEPHCAYTSIHTSA IIIRFSLGEAFSSQRSCMQSSPGTNGKVFLSSK *LWTTSLTH*LFHSIFTCFCFT*IHTVGHHFIT GLSVNSSRPSLR*SWL*SKTVTPSPKANIIKRFH CLKHKCSSLEHFPAMVTRAYPGSWWILPCNTIL VDMIQR*L*FRECVFLSVLKIFELSDGNSFVKH QKLSP*KDAWCI*KSRGTFGAFRRSNHS*PLLLG PSINCCDTQGFLKGSQHWRLVLLSSNFISCAS* ELEYRVL*MLRSCFQNLESNQLSMDLTKTIDDV K*YHLSRA*LPCG*KDESTDYLQIPCILSSTLLL TERITHRFEVCSFPLMKSRLAKR*MTGRKRSQN DPQ*SVQQCRAAVQRLMELTRKKETHAA*NAR* LNYPNYHSIPVFLR*KHLSQH*IDLN*GMR*EEA LLIWRKK*MEDCNRKNTGLGKK*FFSFDAGQGP LYIIQFSCWKASGQTELFQTLQQGRLYFDLLFL GKGNN**SLNVKTFLLNSTFINQFLLVVQRTLTT VSNTTIQFPLWRGDSGVESPGVSC*SLTDDKAL QIPLRTISL*AHREAAVWCGLLWCNHQMWKT*W C*CVGMPG*NSTALQKEREDGMC*YCSGMHFPAL HGALFIYEVIECHYSVPYSRYYLAKVIITMKCC GM**EAFHW

Frame 1

KEEARGAP*GGSG*STVSARLGDAASARTRPRP RGWRVVATGTL*TRSESELPRCPGHGL*GQQRF QPQG*VHHKPTGVWLPPKLF*QQLPQRAGRTGPR AASAGSPVGGLR*AAD*WQPQQPLPLGKNRGRF *KSRRHHPEYCQAPRPGRGQHGP*HPSGPGERP GPAAQEHQPVGGGPEQGPGHCPGAAAAGLP*RHG EGEDHAGAGPAAGQEGGQSHAVLAP*CLSHNSE FY*PEPTHLREELSQKWDGLNGQFQKCDWLKLD VVTAV*LLPV*TEPWHVNSVPREDRLEDSCDFYF KDNVKLITHFKISTLIYLNENVHLHVFEWPSYH PHMNLHICKSTHGAFISTVQVPT*KLNWKAGFK EVETKYNFFGKKKLLFIKVQP*RMVLQQAVSCLR KARIREGTYPLQMKNSTQNRDYLS*Y*GTNNLP V*KTTWHRDSELKCCTQMMGSPAPVHRGLTFST SFPLLESKRTTCGSKRCEGDLRAQVSHCLFTKSG N*LHTLFLFP*HQDFAKDMKPRVPEATAMPREL APW**L*TSNF*PYAQLIHASEVHLERTGF*A* KMKEQLDFLKIQQSGSLS*GQSKPSHLGSTKINK EKLSFRNSATLVCCSSGKLCPRNQFKSTTVDAG SISHTLL*TGNSCDHNMRPLETHMSKGTDGLMI SSYQMLSCSLRV*NHQKGKTNSILFSMQYIPR*G WLN*KWAKAYKY*KEVLPRSVEATVWK*IFLTL RLFMFWSGLLKKFSNHNGNRLNHTAPTHPSIRQ PL*SDSHWGRHFLPKGAVCSHHPELMGKCS*AAS DSGPPLSHTDSSTASSPASVSLEFIQ*ATIL*Q VLV*ILPDQV*DSLGCKARPSPLLPKPTL*KDS IVSNTNVPVLSTSQPW*LGHILAVGGFCPVTQSL WI*FKGDFNSENVFSFLF*KYLN*VMEILLLNI KSFLLEKMLGVSESHVGHLVHSEGQIIPDLSS* DPALTAAILKASLKDHSTGA*FYCPATLLVVLAE NWNIESFECYDLVFKTWSQTN*VWT*QRQLMM* NDTTCQGHSYHVDRKMSPLIIFKSHVFSLARCF *QKE*LTDLKFVPFP**RVDWPKGR*QEGRGARM THSDQFSSAERQCRGSWNSHGKRKHMLLKMHDN LIIQITIQFRYF*DESI*ANTKLTLIKE*GRKR HF*SGGRNKWKTVIGKIQV*EKNNFFPLMLAKDP ST*YSSPAGKHQGKQSYSKLCNREDCTLTFFSW GKGTTSNL*MSKLFF*IVHSLTSFFWWCKEHSP Q*AIPLFNFPFGEVTAG*NHLESAASL*LMTRPC KYP*EQFHSELTGKQQSGVGSCGVTIKCGRPDG VSVWGCRAEIQQPCKKKGKMGCVNIVVACTFQL SMELSLYMR*LNVTILYHTAGII*PRL*LP*SAV ECSRRLFTG

Frame 2

RRKRAGRHKEEAGSRPCPRAWETLPRPGRARAP AAGGWSPLGHCEPGVSRSCRAAQAMDCEVNNGS SLRDECITNLLVFGFLQSCSDNSFRRELDALGH ELPVLAPQWEGYDELQTDGNRSSHSRLGRIEADS ESQEDIIRNIARHLAQVGDSMDRSIPPGLVNGL ALQLRNTSRSEEDRNRDLATALEQLLQAYPRDM EKEKTMLVLALLLAKKVASHTPSLLRDVFHTTVN FINQNLRTYVRSLARNGMD*TDSSRSVTG*SSM WSQLYSCFQCRRSPGMSTAFLEKTGWKIAVTSI LKTMLNL*PTLKYLH*YT*MKMSIYTYLNGLHII HT*ICTSVNLHTVPLFPLCRFPLKN*IGKQVSR K*KQNTIFLVKKNYCLLKYNHRGWSYSRQYPV* GKQESEKEHTPYK*KIPLKIGTIYLNTKEPTIFL FKKPHGTEILN*SAALK*WEVRPQYTGA*LFQL RFLCWSQKEPLVVLKGVKVI*GPRSATVCLQNQ VTNCIHFFSFHDIKTLLKT*SHGCQKLLRCPGS* PPGNSCKLPISSHTLSSSMPQKCIWREQVSKHK R*KSSWTF*KFSKVVPSLRDSQNQVT*VVPK*I RKSLALETVQHWSAVPVVSYVPGISLKARQWMLG PYHTHCCEQETPVTTT*GHWRRI*VRALTDS*F LLTRCFPVL*EFKIIRKEKQTLYCSACNTYHAR AGSIESGQKLTNTKKKCCRAVWRPLFGNKSS*HY DFSCFGVDF*KSFPTTMETG*TTLRLHIHPYVS HYNQILTGGGIFFPKELYAVITRN*WESVLKQQ VTLDHLSHTLTLPQHLHLLLFHLNSYSRPPFYNR S*CKFFQTKSEIVLVVKQDRHPFSQSQHYKKIP LSQTQMFQS*ALPSHGDSGISWQLVDFAL*HNP CGYDSKVTLIQRMCFPFCFKNI*IK*WKFFC*TS KAFSLKRCLVYLKVTWDIWCIQKVKSFLTSPLR TQH*LLRYSRLP*RITALAPSFTVQQLY*LC*L RIGI*SPLNVTILFSKPGVKPIKYGLNKDN**CE MIPPVKGIVTMWIER*VH*LSSNPMYSL*HVAS DRKNNSQI*SLFLSPDEE*IGQKVDDRKEEEPE *PTVISSAVQSGSAEAHGTHTEKGNTCCLKCTIT *LSKLPFNSGIFEMKAFEPTLN*P*LRNEVGRG TFNLEEEINGRL**EKYRSRKKIIFFL*CWPRT PLHNTVLLLESIRANRVIPNSATGKTVL*PSFPG EREQLVIFKCQNFSSK*YIH*PVSSGGAKNTHH SEQYHYSISPLER*QRGRITWSQLLVFN**QGL ANTPENNFTLSSQGSSSLVWAPVV*PSNVEDLMV LVCGDAGLKFNSLAKRKGRWDVLIL*WHALSSS PWSSLYI*GN*MSLFCTIQQVLSSQGYNYHEVL WNVVGGFSL