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Sequences

Sequence SCN5A.hAug05

TCATGGCCCAGCACGACCCTCCACCCTGGACCAAGTATGTCGAGTATGTATCAGAAAATATAAAACTAGGCAATTTGTCGGCTCTTCGAACTTTCAGAGT CCTGAGAGCTCTAAAAACTATTTCAGTTATCCCAGGGCTGAAGACCATCGTGGGGGCCCTGATCCAGTCTGTGAAGAAGCTGGCTGATGTGATGGTCCTC ACAGTCTTCTGCCTCAGCGTCTTTGCCCTCATCGGCCTGCAGCTCTTCATGGGCAACCTAAGGCACAAGTGCGTGCGCAACTTCACAGCGCTCAACGGCA CCAACGGCTCCGTGGAGGCCGACGGCTTGGTCTGGGAATC

SCN5A.F9 (forward primer)
SCN5A.R10 (reverse primer)
Single exon skipping

Frame 0

SWPSTTLHPGPSMSSMYQKI*N*AICRLFELSE S*EL*KLFQLSQG*RPSWGP*SSL*RSWLM*WSS QSSASASLPSSACSSSWAT*GTSACATSQRSTA PTAPWRPTAWSGN

Frame 1

HGPARPSTLDQVCRVCIRKYKTRQFVGSSNFQS PESSKNYFSYPRAEDHRGGPDPVCEEAG*CDGP HSLLPQRLCPHRPAALHGQPKAQVRAQLHSAQRH QRLRGGRRLGLGI

Frame 2

MAQHDPPPWTKYVEYVSENIKLGNLSALRTFRV LRALKTISVIPGLKTIVGALIQSVKKLADVMVL TVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG TNGSVEADGLVWE

Sequence SCN5A.dAug05

GGCAACGTGAGGAGAGCCTGTGCCCAGAAGCAGGATGAGAAGATGGCAAACTTCCTATTACCTCGGGGCACCAGCAGCTTCCGCAGGTTCACACGGGAGT CCCTGGCAGCCATCGAGAAGCGCATGGCAGAGAAGCAAGCCCGCGGCTCAACCACCTTGCAGGAGAGCCGAGAGGGGCTGCCCGAGGAGGAGGCTCCCCG GCCCCAGCTGGACCTGCAGGCCTCCAAAAAGCTGCCAGATCTCTATGGCAATCCACCCCAAGAGCTCATCGGAGAGCCCCTGGAGGACCTGGACCCCTTC TATAGCACCCAAAAGACTTTCATCGTACTGAATAAAGGCAAGACCATCTTCCGGTTCAGTGCCACCAACGCCTTGTATGTCCTCAGTCCCTTCCACCCCA TCCGGAGAGCGGCTGTGAAGATTCTGGTTCACTCGCTCTTCAACATGCTCATCATGTGCACCATCCTCACCAACTGCGTGTTCATGGCCCAGCACGACCC TCCACCCTGGACCAAGTATGTCGAGTACACCTTCACCGCCATTTACACCTTTGAGTCTCTGGTCAAGATTCTGGCTCGAGGCTTCTGCCTGCACGCGTTC ACTTTCCTTCGGGACCCATGGAACTGGCTGGACTTTAGTGTGATTATCATGGCGTATGTATCAGAAAATATAAAACTAGGCAATTTGTCGGCTCTTCGAA CTTTCAGAGTCCTGAGAGCTCTAAAAACTATTTCAGTTATCCCAGGGCTGAAGACCATCGTGGGGGCCCTGATCCAGTCTGTGAAGAAGCTGGCTGATGT GATGGTCCTCACAGTCTTCTGCCTCAGCGTCTTTGCCCTCATCGGCCTGCAGCTCTTCATGGGCAACCTAAGGCACAAGTGCGTGCGCAACTTCACAGCG CTCAACGGCACCAACGGCTCCGTGGAGGCCGACGGCTTGGTCTGGGAATCCCTGGACCTTTACCTCAGTGATCCAGAAAATTACCTGCTCAAGAACGGCA CCTCTGATGTGTTACTGTGTGGGAACAGCTCTGACGCTGGGACATGTCCGGAGGGCTACCGGTGCCTAAAGGCAGGCGAGAACCCCGACCACGGCTACAC CAGCTTCGATTCCTTTGCCTGGGCCTTTCTTGCACTCTTCCGCCTGATGACGCAGGACTGCTGGGAGCGCCTCTATCAGCAGACCCTCAGGTCCGCAGGG AAGATCTACATGATCTTCTTCATGCTTGTCATCTTCCTGGGGTCCTTCTACCTGGTGAACCTGATCCTGGCCGTGGTCGCAATGGCCTATGAGGAGCAAA ACCAAGCCACCATCGCTGAGACCGAGGAGAAGGAAAAGCGCTTCCAGGAGGCCATGGAAATGCTCAAGAAAGAACACGAGGCCCTCACCATCAGGGGTGT GGATACCGTGTCCCGTAGCTCCTTGGAGATGTCCCCTTTGGCCCCAGTAAACAGCCATGAGAGAAGAAGCAAGAGGAGAAAACGGATGTCTTCAGGAACT GAGGAGTGTGGGGAGGACAGGCTCCCCAAGTCTGACTCAGAAGATGGTCCCAGAGCAATGAATCATCTCAGCCTCACCCGTGGCCTCAGCAGGACTTCTA TGAAGCCACGTTCCAGCCGCGGGAGCATTTTCACCTTTCGCAGGCGAGACCTGGGTTCTGAAGCAGATTTTGCAGATGATGAAAACAGCACAGCGGGGGA GAGCGAGAGCCACCACACATCACTGCTGGTGCCCTGGCCCCTGCGCCGGACCAGTGCCCAGGGACAGCCCAGTCCCGGAACCTCGGCTCCTGGCCACGCC CTCCATGGCAAAAAGAACAGCACTGTGGACTGCAATGGGGTGGTCTCATTACTGGGGGCAGGCGACCCAGAGGCCACATCCCCAGGAAGCCACCTCCTCC GCCCTGTGATGCTAGAGCACCCGCCAGACACGACCACGCCATCGGAGGAGCCAGGCGGGCCCCAGATGCTGACCTCCCAGGCTCCGTGTGTAGATGGCTT CGAGGAGCCAGGAGCACGGCAGCGGGCCCTCAGCGCAGTCAGCGTCCTCACCAGCGCACTGGAAGAGTTAGAGGAGTCTCGCCACAAGTGTCCACCATGC TGGAACCGTCTCGCCCAGCGCTACCTGATCTGGGAGTGCTGCCCGCTGTGGATGTCCATCAAGCAGGGAGTGAAGTTGGTGGTCATGGACCCGTTTACTG ACCTCACCATCACTATGTGCATCGTACTCAACACACTCTTCATGGCGCTGGAGCACTACAACATGACAAGTGAATTCGAGGAGATGCTGCAGGTCGGAAA CCTGGTCTTCACAGGGATTTTCACAGCAGAGATGACCTTCAAGATCATTGCCCTCGACCCCTACTACTACTTCCAACAGGGCTGGAACATCTTCGACAGC ATCATCGTCATCCTTAGCCTCATGGAGCTGGGCCTGTCCCGCATGAGCAACTTGTCGGTGCTGCGCTCCTTCCGCCTGCTGCGGGTCTTCAAGCTGGCCA AATCATGGCCCACCCTGAACACACTCATCAAGATCATCGGGAACTCAGTGGGGGCACTGGGGAACCTGACACTGGTGCTAGCCATCATCGTGTTCATCTT TGCTGTGGTGGGCATGCAGCTCTTTGGCAAGAACTACTCGGAGCTGAGGGACAGCGACTCAGGCCTGCTGCCTCGCTGGCACATGATGGACTTCTTTCAT GCCTTCCTCATCATCTTCCGCATCCTCTGTGGAGAGTGGATCGAGACCATGTGGGACTGCATGGAGGTGTCGGGGCAGTCATTATGCCTGCTGGTCTTCT TGCTTGTTATGGTCATTGGCAACCTTGTGGTCCTGAATCTCTTCCTGGCCTTGCTGCTCAGCTCCTTCAGTGCAGACAACCTCACAGCCCCTGATGAGGA CAGAGAGATGAACAACCTCCAGCTGGCCCTGGCCCGCATCCAGAGGGGCCTGCGCTTTGTCAAGCGGACCACCTGGGATTTCTGCTGTGGTCTCCTGCGG CAGCGGCCTCAGAAGCCCGCAGCCCTTGCCGCCCAGGGCCAGCTGCCCAGCTGCATTGCCACCCCCTACTCCCCGCCACCCCCAGAGACGGAGAAGGTGC CTCCCACCCGCAAGGAAACACGGTTTGAGGAAGGCGAGCAACCAGGCCAGGGCACCCCCGGGGATCCAGAGCCCGTGTGTGTGCCCATCGCTGTGGCCGA GTCAGACACAGATGACCAAGAAGAAGATGAGGAGAACAGCCTGGGCACGGAGGAGGAGTCCAGCAAGCAGACCCCAGAGGACAGTTGCTCCGAGGGCAGC ACAGCAGACATGACCAACACCGCTGAGCTCCTGGAGCAGATCCCTGACCTCGGCCAGGATGTCAAGGACCCAGAGGACTGCTTCACTGAAGGCTGTGTCC GGCGCTGTCCCTGCTGTGCGGTGGACACCACACAGGCCCCAGGGAAGGTCTGGTGGCGGTTGCGCAAGACCTGCTACCACATCGTGGAGCACAGCTGGTT CGAGACATTCATCATCTTCATGATCCTACTCAGCAGTGGAGCGCTGGCCTTCGAGGACATCTACCTAGAGGAGCGGAAGACCATCAAGGTTCTGCTTGAG TATGCCGACAAGATGTTCACATATGTCTTCGTGCTGGAGATGCTGCTCAAGTGGGTGGCCTACGGCTTCAAGAAGTACTTCACCAATGCCTGGTGCTGGC TCGACTTCCTCATCGTAGACGTCTCTCTGGTCAGCCTGGTGGCCAACACCCTGGGCTTTGCCGAGATGGGCCCCATCAAGTCACTGCGGACGCTGCGTGC ACTCCGTCCTCTGAGAGCTCTGTCACGATTTGAGGGCATGAGGGTGGTGGTCAATGCCCTGGTGGGCGCCATCCCGTCCATCATGAACGTCCTCCTCGTC TGCCTCATCTTCTGGCTCATCTTCAGCATCATGGGCGTGAACCTCTTTGCGGGGAAGTTTGGGAGGTGCATCAACCAGACAGAGGGAGACTTGCCTTTGA ACTACACCATCGTGAACAACAAGAGCCAGTGTGAGTCCTTGAACTTGACCGGAGAATTGTACTGGACCAAGGTGAAAGTCAACTTTGACAACGTGGGGGC CGGGTACCTGGCCCTTCTGCAGGTGGCAACATTTAAAGGCTGGATGGACATTATGTATGCAGCTGTGGACTCCAGGGGGTATGAAGAGCAGCCTCAGTGG GAATACAACCTCTACATGTACATCTATTTTGTCATTTTCATCATCTTTGGGTCTTTCTTCACCCTGAACCTCTTTATTGGTGTCATCATTGACAACTTCA ACCAACAGAAGAAAAAGTTAGGGGGCCAGGACATCTTCATGACAGAGGAGCAGAAGAAGTACTACAATGCCATGAAGAAGCTGGGCTCCAAGAAGCCCCA GAAGCCCATCCCACGGCCCCTGAACAAGTACCAGGGCTTCATATTCGACATTGTGACCAAGCAGGCCTTTGACGTCACCATCATGTTTCTGATCTGCTTG AATATGGTGACCATGATGGTGGAGACAGATGACCAAAGTCCTGAGAAAATCAACATCTTGGCCAAGATCAACCTGCTCTTTGTGGCCATCTTCACAGGCG AGTGTATTGTCAAGCTGGCTGCCCTGCGCCACTACTACTTCACCAACAGCTGGAATATCTTCGACTTCGTGGTTGTCATCCTCTCCATCGTGGGCACTGT GCTCTCGGACATCATCCAGAAGTACTTCTTCTCCCCGACGCTCTTCCGAGTCATCCGCCTGGCCCGAATAGGCCGCATCCTCAGACTGATCCGAGGGGCC AAGGGGATCCGCACGCTGCTCTTTGCCCTCATGATGTCCCTGCCTGCCCTCTTCAACATCGGGCTGCTGCTCTTCCTCGTCATGTTCATCTACTCCATCT TTGGCATGGCCAACTTCGCTTATGTCAAGTGGGAGGCTGGCATCGACGACATGTTCAACTTCCAGACCTTCGCCAACAGCATGCTGTGCCTCTTCCAGAT CACCACGTCGGCCGGCTGGGATGGCCTCCTCAGCCCCATCCTCAACACTGGGCCGCCCTACTGCGACCCCACTCTGCCCAACAGCAATGGCTCTCGGGGG GACTGCGGGAGCCCAGCCGTGGGCATCCTCTTCTTCACCACCTACATCATCATCTCCTTCCTCATCGTGGTCAACATGTACATTGCCATCATCCTGGAGA ACTTCAGCGTGGCCACGGAGGAGAGCACCGAGCCCCTGAGTGAGGACGACTTCGATATGTTCTATGAGATCTGGGAGAAATTTGACCCAGAGGCCACTCA GTTTATTGAGTATTCGGTCCTGTCTGACTTTGCCGATGCCCTGTCTGAGCCACTCCGTATCGCCAAGCCCAACCAGATAAGCCTCATCAACATGGACCTG CCCATGGTGAGTGGGGACCGCATCCATTGCATGGACATTCTCTTTGCCTTCACCAAAAGGGTCCTGGGGGAGTCTGGGGAGATGGACGCCCTGAAGATCC AGATGGAGGAGAAGTTCATGGCAGCCAACCCATCCAAGATCTCCTACGAGCCCATCACCACCACACTCCGGCGCAAGCACGAAGAGGTGTCGGCCATGGT TATCCAGAGAGCCTTCCGCAGGCACCTGCTGCAACGCTCTTTGAAGCATGCCTCCTTCCTCTTCCGTCAGCAGGCGGGCAGCGGCCTCTCCGAAGAGGAT GCCCCTGAGCGAGAGGGCCTCATCGCCTACGTGATGAGTGAGAACTTCTCCCGACCCCTTGGCCCACCCTCCAGCTCCTCCATCTCCTCCACTTCCTTCC CACCCTCCTATGACAGTGTCACTAGAGCCACCAGCGATAACCTCCAGGTGCGGGGGTCTGACTACAGCCACAGTGAAGATCTCGCCGACTTCCCCCCTTC TCCGGACAGGGACCGTGAGTCCATCGTGTGAGCCTCGGCCTGGCTGGCCAGGACACACTGAAAAGCAGCCTTTTTCACCATGGCAAACCTAAATGCAGTC AGTCACAAACCAGCCTGGGGCCTTCCTGGCTTTGGGAGTAAGAAATGGGCCTCAGCCCCGCGGATCAACCAGGCAGAGTTCTGTGGCGCCGCGTGGACAG CCGGAGCAGTTGGCCTGTGCTTGGAGGCCTCAGATAGACCTGTGACCTGGTCTGGTCAGGCAATGCCCTGCGGCTCTGGAAAGCAACTTCATCCCAGCTG CTGAGGCGAAATATAAAACTGAGACTGTATATGTTGTGAATGGGCTTTCATAAATTTATTATATTTGATATTTTTTTACTTGAGCAAAGAACTAAGGATT TTTCCATGGACATGGGCAGCAATTCACGCTGTCTCTTCTTAACCCTGAACAAGAGTGTCTATGGAGCAGCCGGAAGTCTGTTCTCAAAGCAGAAGTGGAA TCCAGTGTGGCTCCCACAGGTCTTCACTGCCCAGGGGTCGAATGGGGTCCCCCTCCCACTTGACCTGAGATGCTGGGAGGGCTGAACCCCCACTCACACA AGCACACACACACAGTCCTCACACACGGAGGCCAGACACAGGCCGTGGGACCCAGGCTCCCAGCCTAAGGGAGACAGGCCTTTCCCTGCCGGCCCCCCAA GGATGGGGTTCTTGTCCACGGGGCTCACTCTGGCCCCCTATTGTCTCCAAGGTCCCATTTTCCCCCTGTGTTTTCACGCAGGTCATATTGTCAGTCCTAC AAAAATAAAAGGCTTCCAGAGGAGAGTGGCCTGGGTCCCAGGGCTGGCCCTAGGCACTGATAGTTGCCTTTTCTTCCCCTCCTGTAAGAGTATTAACAAA ACCAAAGGACACAAGGGTGCAAGCCCCATTCACGGCCTGGCATGCAGCTTGTCCTTGCTCCTGGAACCTGGCAGGCCCTGCCCAGCCAGCCATCGGAAGA GAGGGCTGAGCCATGGGGGTTTGGGGCTAAGAAGTTCACCAGCCCTGAGCCATGGCGGCCCCTCAGCCTGCCTGAAGAGAGGAAACTGGCGATCTCCCAG GGCTCTCTGGACCATACGCGGAGGAGTTTTCTGTGTGGTCTCCAGCTCCTCTCCAGACACAGAGACATGGGAGTGGGGAGCGGAGCTTGGCCCTGCGCCC TGTGCAGGGAAAGGGATGGTCAGGCCCAGTTCTCGTGCCCTTAGAGGGGAATGAACCATGGCACCTTTGAGAGAGGGGGCACTGTGGTCAGGCCCAGCCT CTCTGGCTCAGCCCGGGATCCTGATGGCACCCACACAGAGGACCTCTTTGGGGCAAGATCCAGGTGGTCCCATAGGTCTTGTGAAAAGGCTTTTTCAGGG AAAAATATTTTACTAGTCCAATCACCCCCAGGACCTCTTCAGCTGCTGACAATCCTATTTAGCATATGCAAATCTTTTAACATAGAGAACTGTCACCCTG AGGTAACAGGGTCAACTGGCGAAGCCTGAGCAGGCAGGGGCTTGGCTGCCCCATTCCAGCTCTCCCATGGAGCCCCTCCACCGGGCGCATGCCTCCCAGG CCACCTCAGTCTCACCTGCCGGCTCTGGGCTGGCTGCTCCTAACCTACCTCGCCGAGCTGTCGGAGGGCTGGACATTTGTGGCAGTGCTGAAGGGGGCAT TGCCGGCGAGTAAAGTATTATGTTTCTTCTTGTCACCCCAGTTCCCTTGGTGGCAACCCCAGACCCAACCCATGCCCCTGACAGATCTAGTTCTCTTCTC CTGTGTTCCCTTTGAGTCCAGTGTGGGACACGGTTTAACTGTCCCAGCGACATTTCTCCAAGTGGAAATCCTATTTTTGTAGATCTCCATGCTTTGCTCT CAAGGCTTGGAGAGGTATGTGCCCCTCCTGGGTGCTCACCGCCTGCTACACAGGCAGGAATGCGGTTGGGAGGCAGGTCGGGCTGCCAGCCCAGCTGGCC GGAAGGAGACTGTGGTTTTTGTGTGTGTGGACAGCCCGGGAGCTTTGAGACAGGTGCCTGGGGCTGGCTGCAGACGGTGTGGTTGGGGGTGGGAGGTGAG CTAGACCCAACCCTTAGCTTTTAGCCTGGCTGTCACCTTTTTAATTTCCAGAACTGCACAATGACCAGCAGGAGGGAAGGACAGACATCAAGTGCCAGAT GTTGTCTGAACTAATCGAGCACTTCTCACCAAACTTCATGTATAAATAAAATACATATTTTTAAAACAAACCAATAAATGGCTTACATG

SCN5A.F9 (forward primer)
SCN5A.R10 (reverse primer)
Single exon skipping

Frame 0

GNVRRACAQKQDEKMANFLLPRGTSSFRRFTRE SLAAIEKRMAEKQARGSTTLQESREGLPEEEAPR PQLDLQASKKLPDLYGNPPQELIGEPLEDLDPF YSTQKTFIVLNKGKTIFRFSATNALYVLSPFHP IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP PPWTKYVEYTFTAIYTFESLVKILARGFCLHAF TFLRDPWNWLDFSVIIMAYVSENIKLGNLSALR TFRVLRALKTISVIPGLKTIVGALIQSVKKLADV MVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTA LNGTNGSVEADGLVWESLDLYLSDPENYLLKNG TSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYT SFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQ NQATIAETEEKEKRFQEAMEMLKKEHEALTIRGV DTVSRSSLEMSPLAPVNSHERRSKRRKRMSSGT EECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTS MKPRSSRGSIFTFRRRDLGSEADFADDENSTAGE SESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHA LHGKKNSTVDCNGVVSLLGAGDPEATSPGSHLL RPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGF EEPGARQRALSAVSVLTSALEELEESRHKCPPC WNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFT DLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGN LVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDS IIVILSLMELGLSRMSNLSVLRSFRLLRVFKLA KSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIF AVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFH AFLIIFRILCGEWIETMWDCMEVSGQSLCLLVF LLVMVIGNLVVLNLFLALLLSSFSADNLTAPDED REMNNLQLALARIQRGLRFVKRTTWDFCCGLLR QRPQKPAALAAQGQLPSCIATPYSPPPPETEKV PPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAE SDTDDQEEDEENSLGTEEESSKQTPEDSCSEGS TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCV RRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWF ETFIIFMILLSSGALAFEDIYLEERKTIKVLLE YADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCW LDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRA LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLV CLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPL NYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGA GYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNF NQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQ KPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICL NMVTMMVETDDQSPEKINILAKINLLFVAIFTG ECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTV LSDIIQKYFFSPTLFRVIRLARIGRILRLIRGA KGIRTLLFALMMSLPALFNIGLLLFLVMFIYSI FGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQI TTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG DCGSPAVGILFFTTYIIISFLIVVNMYIAIILE NFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQ FIEYSVLSDFADALSEPLRIAKPNQISLINMDL PMVSGDRIHCMDILFAFTKRVLGESGEMDALKI QMEEKFMAANPSKISYEPITTTLRRKHEEVSAMV IQRAFRRHLLQRSLKHASFLFRQQAGSGLSEED APEREGLIAYVMSENFSRPLGPPSSSSISSTSF PPSYDSVTRATSDNLQVRGSDYSHSEDLADFPPS PDRDRESIV*ASAWLARTH*KAAFFTMANLNAV SHKPAWGLPGFGSKKWASAPRINQAEFCGAAWT AGAVGLCLEASDRPVTWSGQAMPCGSGKQLHPSC *GEI*N*DCICCEWAFINLLYLIFFYLSKELRI FPWTWAAIHAVSS*P*TRVSMEQPEVCSQSRSG IQCGSHRSSLPRGRMGSPSHLT*DAGRAEPPLTQ AHTHSPHTRRPDTGRGTQAPSLRETGLSLPAPQ GWGSCPRGSLWPPIVSKVPFSPCVFTQVILSVL QK*KASRGEWPGSQGWP*ALIVAFSSPPVRVLTK PKDTRVQAPFTAWHAACPCSWNLAGPAQPAIGR EG*AMGVWG*EVHQP*AMAAPQPA*REETGDLP GLSGPYAEEFSVWSPAPLQTQRHGSGERSLALRP VQGKGWSGPVLVPLEGNEPWHL*ERGHCGQAQP LWLSPGS*WHPHRGPLWGKIQVVP*VL*KGFFR EKYFTSPITPRTSSAADNPI*HMQIF*HRELSP* GNRVNWRSLSRQGLGCPIPALPWSPSTGRMPPR PPQSHLPALGWLLLTYLAELSEGWTFVAVLKGA LPASKVLCFFLSPQFPWWQPQTQPMPLTDLVLFS CVPFESSVGHGLTVPATFLQVEILFL*ISMLCS QGLERYVPLLGAHRLLHRQECGWEAGRAASPAG RKETVVFVCVDSPGALRQVPGAGCRRCGWGWEVS *TQPLAFSLAVTFLISRTAQ*PAGGKDRHQVPD VV*TNRALLTKLHV*IKYIFLKQTNKWLT

Frame 1

AT*GEPVPRSRMRRWQTSYYLGAPAASAGSHGS PWQPSRSAWQRSKPAAQPPCRRAERGCPRRRLP GPSWTCRPPKSCQISMAIHPKSSSESPWRTWTPS IAPKRLSSY*IKARPSSGSVPPTPCMSSVPSTP SGERL*RFWFTRSSTCSSCAPSSPTACSWPSTT LHPGPSMSSTPSPPFTPLSLWSRFWLEASACTRS LSFGTHGTGWTLV*LSWRMYQKI*N*AICRLFE LSES*EL*KLFQLSQG*RPSWGP*SSL*RSWLM *WSSQSSASASLPSSACSSSWAT*GTSACATSQR STAPTAPWRPTAWSGNPWTFTSVIQKITCSRTA PLMCYCVGTALTLGHVRRATGA*RQARTPTTAT PASIPLPGPFLHSSA**RRTAGSASISRPSGPQG RST*SSSCLSSSWGPSTW*T*SWPWSQWPMRSK TKPPSLRPRRRKSASRRPWKCSRKNTRPSPSGV WIPCPVAPWRCPLWPQ*TAMREEARGENGCLQEL RSVGRTGSPSLTQKMVPEQ*IISASPVASAGLL *SHVPAAGAFSPFAGETWVLKQILQMMKTAQRG RARATTHHCWCPGPCAGPVPRDSPVPEPRLLATP SMAKRTALWTAMGWSHYWGQATQRPHPQEATSS AL*C*STRQTRPRHRRSQAGPRC*PPRLRV*MA SRSQEHGSGPSAQSASSPAHWKS*RSLATSVHHA GTVSPSAT*SGSAARCGCPSSRE*SWWSWTRLL TSPSLCASYSTHSSWRWSTTT*QVNSRRCCRSE TWSSQGFSQQR*PSRSLPSTPTTTSNRAGTSSTA SSSSLASWSWACPA*ATCRCCAPSACCGSSSWP NHGPP*THSSRSSGTQWGHWGT*HWC*PSSCSS LLWWACSSLARTTRS*GTATQACCLAGT*WTSFM PSSSSSASSVESGSRPCGTAWRCRGSHYACWSS CLLWSLATLWS*ISSWPCCSAPSVQTTSQPLMR TER*TTSSWPWPASRGACALSSGPPGISAVVSCG SGLRSPQPLPPRASCPAALPPPTPRHPQRRRRC LPPARKHGLRKASNQARAPPGIQSPCVCPSLWP SQTQMTKKKMRRTAWARRRSPASRPQRTVAPRAA QQT*PTPLSSWSRSLTSARMSRTQRTASLKAVS GAVPAVRWTPHRPQGRSGGGCARPATTSWSTAG SRHSSSS*SYSAVERWPSRTST*RSGRPSRFCLS MPTRCSHMSSCWRCCSSGWPTASRSTSPMPGAG STSSS*TSLWSAWWPTPWALPRWAPSSHCGRCV HSVL*ELCHDLRA*GWWSMPWWAPSRPS*TSSSS ASSSGSSSASWA*TSLRGSLGGASTRQRETCL* TTPS*TTRASVSP*T*PENCTGPR*KSTLTTWG PGTWPFCRWQHLKAGWTLCMQLWTPGGMKSSLSG NTTSTCTSILSFSSSLGLSSP*TSLLVSSLTTS TNRRKS*GARTSS*QRSRRSTTMP*RSWAPRSP RSPSHGP*TSTRASYSTL*PSRPLTSPSCF*SA* IW*P*WWRQMTKVLRKSTSWPRSTCSLWPSSQA SVLSSWLPCATTTSPTAGISSTSWLSSSPSWAL CSRTSSRSTSSPRRSSESSAWPE*AASSD*SEGP RGSARCSLPS*CPCLPSSTSGCCSSSSCSSTPS LAWPTSLMSSGRLASTTCSTSRPSPTACCASSR SPRRPAGMASSAPSSTLGRPTATPLCPTAMALGG TAGAQPWASSSSPPTSSSPSSSWSTCTLPSSWR TSAWPRRRAPSP*VRTTSICSMRSGRNLTQRPL SLLSIRSCLTLPMPCLSHSVSPSPTR*ASSTWTC PW*VGTASIAWTFSLPSPKGSWGSLGRWTP*RS RWRRSSWQPTHPRSPTSPSPPHSGASTKRCRPW LSREPSAGTCCNAL*SMPPSSSVSRRAAASPKRM PLSERASSPT**VRTSPDPLAHPPAPPSPPLPS HPPMTVSLEPPAITSRCGGLTTATVKISPTSPL LRTGTVSPSCEPRPGWPGHTEKQPFSPWQT*MQS VTNQPGAFLALGVRNGPQPRGSTRQSSVAPRGQ PEQLACAWRPQIDL*PGLVRQCPAALESNFIPA AEAKYKTETVYVVNGLS*IYYI*YFFT*AKN*GF FHGHGQQFTLSLLNPEQECLWSSRKSVLKAEVE SSVAPTGLHCPGVEWGPPPT*PEMLGGLNPHSH KHTHTVLTHGGQTQAVGPRLPA*GRQAFPCRPPK DGVLVHGAHSGPLLSPRSHFPPVFSRRSYCQSY KNKRLPEESGLGPRAGPRH**LPFLPLL*EY*Q NQRTQGCKPHSRPGMQLVLAPGTWQALPSQPSEE RAEPWGFGAKKFTSPEPWRPLSLPEERKLAISQ GSLDHTRRSFLCGLQLLSRHRDMGVGSGAWPCA LCRERDGQAQFSCP*RGMNHGTFERGGTVVRPSL SGSARDPDGTHTEDLFGARSRWSHRSCEKAFSG KNILLVQSPPGPLQLLTILFSICKSFNIENCHP EVTGSTGEA*AGRGLAAPFQLSHGAPPPGACLPG HLSLTCRLWAGCS*PTSPSCRRAGHLWQC*RGH CRRVKYYVSSCHPSSLGGNPRPNPCP*QI*FSS PVFPLSPVWDTV*LSQRHFSKWKSYFCRSPCFAL KAWRGMCPSWVLTACYTGRNAVGRQVGLPAQLA GRRLWFLCVWTAREL*DRCLGLAADGVVGGGR* ARPNP*LLAWLSPF*FPELHNDQQEGRTDIKCQM LSELIEHFSPNFMYK*NTYF*NKPINGLH

Frame 2

QREESLCPEAG*EDGKLPITSGHQQLPQVHTGV PGSHREAHGREASPRLNHLAGEPRGAARGGGSP APAGPAGLQKAARSLWQSTPRAHRRAPGGPGPL L*HPKDFHRTE*RQDHLPVQCHQRLVCPQSLPPH PESGCEDSGSLALQHAHHVHHPHQLRVHGPARP STLDQVCRVHLHRHLHL*VSGQDSGSRLLPARV HFPSGPMELAGL*CDYHGVCIRKYKTRQFVGSSN FQSPESSKNYFSYPRAEDHRGGPDPVCEEAG*C DGPHSLLPQRLCPHRPAALHGQPKAQVRAQLHS AQRHQRLRGGRRLGLGIPGPLPQ*SRKLPAQERH L*CVTVWEQL*RWDMSGGLPVPKGRREPRPRLH QLRFLCLGLSCTLPPDDAGLLGAPLSADPQVRR EDLHDLLHACHLPGVLLPGEPDPGRGRNGL*GAK PSHHR*DRGEGKALPGGHGNAQERTRGPHHQGC GYRVP*LLGDVPFGPSKQP*EKKQEEKTDVFRN *GVWGGQAPQV*LRRWSQSNESSQPHPWPQQDFY EATFQPREHFHLSQARPGF*SRFCR**KQHSGG EREPPHITAGALAPAPDQCPGTAQSRNLGSWPR PPWQKEQHCGLQWGGLITGGRRPRGHIPRKPPPP PCDARAPARHDHAIGGARRAPDADLPGSVCRWL RGARSTAAGPQRSQRPHQRTGRVRGVSPQVSTM LEPSRPALPDLGVLPAVDVHQAGSEVGGHGPVY* PHHHYVHRTQHTLHGAGALQHDK*IRGDAAGRK PGLHRDFHSRDDLQDHCPRPLLLLPTGLEHLRQ HHRHP*PHGAGPVPHEQLVGAALLPPAAGLQAGQ IMAHPEHTHQDHRELSGGTGEPDTGASHHRVHL CCGGHAALWQELLGAEGQRLRPAASLAHDGLLS CLPHHLPHPLWRVDRDHVGLHGGVGAVIMPAGLL ACYGHWQPCGPESLPGLAAQLLQCRQPHSP**G QRDEQPPAGPGPHPEGPALCQADHLGFLLWSPA AAASEARSPCRPGPAAQLHCHPLLPATPRDGEGA SHPQGNTV*GRRATRPGHPRGSRARVCAHRCGR VRHR*PRRR*GEQPGHGGGVQQADPRGQLLRGQ HSRHDQHR*APGADP*PRPGCQGPRGLLH*RLCP ALSLLCGGHHTGPREGLVAVAQDLLPHRGAQLV RDIHHLHDPTQQWSAGLRGHLPRGAEDHQGSA* VCRQDVHICLRAGDAAQVGGLRLQEVLHQCLVLA RLPHRRRLSGQPGGQHPGLCRDGPHQVTADAAC TPSSESSVTI*GHEGGGQCPGGRHPVHHERPPR LPHLLAHLQHHGREPLCGEVWEVHQPDRGRLAFE LHHREQQEPV*VLELDRRIVLDQGESQL*QRGG RVPGPSAGGNI*RLDGHYVCSCGLQGV*RAASV GIQPLHVHLFCHFHHLWVFLHPEPLYWCHH*QLQ PTEEKVRGPGHLHDRGAEEVLQCHEEAGLQEAP EAHPTAPEQVPGLHIRHCDQAGL*RHHHVSDLL EYGDHDGGDR*PKS*ENQHLGQDQPALCGHLHRR VYCQAGCPAPLLLHQQLEYLRLRGCHPLHRGHC ALGHHPEVLLLPDALPSHPPGPNRPHPQTDPRG QGDPHAALCPHDVPACPLQHRAAALPRHVHLLHL WHGQLRLCQVGGWHRRHVQLPDLRQQHAVPLPD HHVGRLGWPPQPHPQHWAALLRPHSAQQQWLSG GLREPSRGHPLLHHLHHHLLPHRGQHVHCHHPGE LQRGHGGEHRAPE*GRLRYVL*DLGEI*PRGHS VY*VFGPV*LCRCPV*ATPYRQAQPDKPHQHGP AHGEWGPHPLHGHSLCLHQKGPGGVWGDGRPEDP DGGEVHGSQPIQDLLRAHHHHTPAQARRGVGHG YPESLPQAPAATLFEACLLPLPSAGGQRPLRRG CP*ARGPHRLRDE*ELLPTPWPTLQLLHLLHFLP TLL*QCH*SHQR*PPGAGV*LQPQ*RSRRLPPF SGQGP*VHRVSLGLAGQDTLKSSLFHHGKPKCS QSQTSLGPSWLWE*EMGLSPADQPGRVLWRRVDS RSSWPVLGGLR*TCDLVWSGNALRLWKATSSQL LRRNIKLRLYML*MGFHKFIIFDIFLLEQRTKD FSMDMGSNSRCLFLTLNKSVYGAAGSLFSKQKWN PVWLPQVFTAQGSNGVPLPLDLRCWEG*TPTHT STHTQSSHTEARHRPWDPGSQPKGDRPFPAGPP RMGFLSTGLTLAPYCLQGPIFPLCFHAGHIVSPT KIKGFQRRVAWVPGLALGTDSCLFFPSCKSINK TKGHKGASPIHGLACSLSLLLEPGRPCPASHRK RGLSHGGLGLRSSPALSHGGPSACLKRGNWRSPR ALWTIRGGVFCVVSSSSPDTETWEWGAELGPAP CAGKGMVRPSSRALRGE*TMAPLREGALWSGPA SLAQPGILMAPTQRTSLGQDPGGPIGLVKRLFQG KIFY*SNHPQDLFSC*QSYLAYANLLT*RTVTL R*QGQLAKPEQAGAWLPHSSSPMEPLHRAHASQ ATSVSPAGSGLAAPNLPRRAVGGLDICGSAEGGI AGE*SIMFLLVTPVPLVATPDPTHAPDRSSSLL LCSL*VQCGTRFNCPSDISPSGNPIFVDLHALL SRLGEVCAPPGCSPPATQAGMRLGGRSGCQPSWP EGDCGFCVCGQPGSFETGAWGWLQTVWLGVGGE LDPTLSF*PGCHLFNFQNCTMTSRREGQTSSAR CCLN*SSTSHQTSCINKIHIFKTNQ*MAYM

Sequence SCN5A.cAug05

GGCAACGTGAGGAGAGCCTGTGCCCAGAAGCAGGATGAGAAGATGGCAAACTTCCTATTACCTCGGGGCACCAGCAGCTTCCGCAGGTTCACACGGGAGT CCCTGGCAGCCATCGAGAAGCGCATGGCAGAGAAGCAAGCCCGCGGCTCAACCACCTTGCAGGAGAGCCGAGAGGGGCTGCCCGAGGAGGAGGCTCCCCG GCCCCAGCTGGACCTGCAGGCCTCCAAAAAGCTGCCAGATCTCTATGGCAATCCACCCCAAGAGCTCATCGGAGAGCCCCTGGAGGACCTGGACCCCTTC TATAGCACCCAAAAGACTTTCATCGTACTGAATAAAGGCAAGACCATCTTCCGGTTCAGTGCCACCAACGCCTTGTATGTCCTCAGTCCCTTCCACCCCA TCCGGAGAGCGGCTGTGAAGATTCTGGTTCACTCGCTCTTCAACATGCTCATCATGTGCACCATCCTCACCAACTGCGTGTTCATGGCCCAGCACGACCC TCCACCCTGGACCAAGTATGTCGAGTACACCTTCACCGCCATTTACACCTTTGAGTCTCTGGTCAAGATTCTGGCTCGAGGCTTCTGCCTGCACGCGTTC ACTTTCCTTCGGGACCCATGGAACTGGCTGGACTTTAGTGTGATTATCATGGCGTATGTATCAGAAAATATAAAACTAGGCAATTTGTCGGCTCTTCGAA CTTTCAGAGTCCTGAGAGCTCTAAAAACTATTTCAGTTATCCCAGGGCTGAAGACCATCGTGGGGGCCCTGATCCAGTCTGTGAAGAAGCTGGCTGATGT GATGGTCCTCACAGTCTTCTGCCTCAGCGTCTTTGCCCTCATCGGCCTGCAGCTCTTCATGGGCAACCTAAGGCACAAGTGCGTGCGCAACTTCACAGCG CTCAACGGCACCAACGGCTCCGTGGAGGCCGACGGCTTGGTCTGGGAATCCCTGGACCTTTACCTCAGTGATCCAGAAAATTACCTGCTCAAGAACGGCA CCTCTGATGTGTTACTGTGTGGGAACAGCTCTGACGCTGGGACATGTCCGGAGGGCTACCGGTGCCTAAAGGCAGGCGAGAACCCCGACCACGGCTACAC CAGCTTCGATTCCTTTGCCTGGGCCTTTCTTGCACTCTTCCGCCTGATGACGCAGGACTGCTGGGAGCGCCTCTATCAGCAGACCCTCAGGTCCGCAGGG AAGATCTACATGATCTTCTTCATGCTTGTCATCTTCCTGGGGTCCTTCTACCTGGTGAACCTGATCCTGGCCGTGGTCGCAATGGCCTATGAGGAGCAAA ACCAAGCCACCATCGCTGAGACCGAGGAGAAGGAAAAGCGCTTCCAGGAGGCCATGGAAATGCTCAAGAAAGAACACGAGGCCCTCACCATCAGGGGTGT GGATACCGTGTCCCGTAGCTCCTTGGAGATGTCCCCTTTGGCCCCAGTAAACAGCCATGAGAGAAGAAGCAAGAGGAGAAAACGGATGTCTTCAGGAACT GAGGAGTGTGGGGAGGACAGGCTCCCCAAGTCTGACTCAGAAGATGGTCCCAGAGCAATGAATCATCTCAGCCTCACCCGTGGCCTCAGCAGGACTTCTA TGAAGCCACGTTCCAGCCGCGGGAGCATTTTCACCTTTCGCAGGCGAGACCTGGGTTCTGAAGCAGATTTTGCAGATGATGAAAACAGCACAGCGGGGGA GAGCGAGAGCCACCACACATCACTGCTGGTGCCCTGGCCCCTGCGCCGGACCAGTGCCCAGGGACAGCCCAGTCCCGGAACCTCGGCTCCTGGCCACGCC CTCCATGGCAAAAAGAACAGCACTGTGGACTGCAATGGGGTGGTCTCATTACTGGGGGCAGGCGACCCAGAGGCCACATCCCCAGGAAGCCACCTCCTCC GCCCTGTGATGCTAGAGCACCCGCCAGACACGACCACGCCATCGGAGGAGCCAGGCGGGCCCCAGATGCTGACCTCCCAGGCTCCGTGTGTAGATGGCTT CGAGGAGCCAGGAGCACGGCAGCGGGCCCTCAGCGCAGTCAGCGTCCTCACCAGCGCACTGGAAGAGTTAGAGGAGTCTCGCCACAAGTGTCCACCATGC TGGAACCGTCTCGCCCAGCGCTACCTGATCTGGGAGTGCTGCCCGCTGTGGATGTCCATCAAGCAGGGAGTGAAGTTGGTGGTCATGGACCCGTTTACTG ACCTCACCATCACTATGTGCATCGTACTCAACACACTCTTCATGGCGCTGGAGCACTACAACATGACAAGTGAATTCGAGGAGATGCTGCAGGTCGGAAA CCTGGTCTTCACAGGGATTTTCACAGCAGAGATGACCTTCAAGATCATTGCCCTCGACCCCTACTACTACTTCCAACAGGGCTGGAACATCTTCGACAGC ATCATCGTCATCCTTAGCCTCATGGAGCTGGGCCTGTCCCGCATGAGCAACTTGTCGGTGCTGCGCTCCTTCCGCCTGCTGCGGGTCTTCAAGCTGGCCA AATCATGGCCCACCCTGAACACACTCATCAAGATCATCGGGAACTCAGTGGGGGCACTGGGGAACCTGACACTGGTGCTAGCCATCATCGTGTTCATCTT TGCTGTGGTGGGCATGCAGCTCTTTGGCAAGAACTACTCGGAGCTGAGGGACAGCGACTCAGGCCTGCTGCCTCGCTGGCACATGATGGACTTCTTTCAT GCCTTCCTCATCATCTTCCGCATCCTCTGTGGAGAGTGGATCGAGACCATGTGGGACTGCATGGAGGTGTCGGGGCAGTCATTATGCCTGCTGGTCTTCT TGCTTGTTATGGTCATTGGCAACCTTGTGGTCCTGAATCTCTTCCTGGCCTTGCTGCTCAGCTCCTTCAGTGCAGACAACCTCACAGCCCCTGATGAGGA CAGAGAGATGAACAACCTCCAGCTGGCCCTGGCCCGCATCCAGAGGGGCCTGCGCTTTGTCAAGCGGACCACCTGGGATTTCTGCTGTGGTCTCCTGCGG CAGCGGCCTCAGAAGCCCGCAGCCCTTGCCGCCCAGGGCCAGCTGCCCAGCTGCATTGCCACCCCCTACTCCCCGCCACCCCCAGAGACGGAGAAGGTGC CTCCCACCCGCAAGGAAACACGGTTTGAGGAAGGCGAGCAACCAGGCCAGGGCACCCCCGGGGATCCAGAGCCCGTGTGTGTGCCCATCGCTGTGGCCGA GTCAGACACAGATGACCAAGAAGAAGATGAGGAGAACAGCCTGGGCACGGAGGAGGAGTCCAGCAAGCAGCAGGAATCCCAGCCTGTGTCCGGTGGCCCA GAGGCCCCTCCGGATTCCAGGACCTGGAGCCAGGTGTCAGCGACTGCCTCCTCTGAGGCCGAGGCCAGTGCATCTCAGGCCGACTGGCGGCAGCAGTGGA AAGCGGAACCCCAGGCCCCAGGGTGCGGTGAGACCCCAGAGGACAGTTGCTCCGAGGGCAGCACAGCAGACATGACCAACACCGCTGAGCTCCTGGAGCA GATCCCTGACCTCGGCCAGGATGTCAAGGACCCAGAGGACTGCTTCACTGAAGGCTGTGTCCGGCGCTGTCCCTGCTGTGCGGTGGACACCACACAGGCC CCAGGGAAGGTCTGGTGGCGGTTGCGCAAGACCTGCTACCACATCGTGGAGCACAGCTGGTTCGAGACATTCATCATCTTCATGATCCTACTCAGCAGTG GAGCGCTGGCCTTCGAGGACATCTACCTAGAGGAGCGGAAGACCATCAAGGTTCTGCTTGAGTATGCCGACAAGATGTTCACATATGTCTTCGTGCTGGA GATGCTGCTCAAGTGGGTGGCCTACGGCTTCAAGAAGTACTTCACCAATGCCTGGTGCTGGCTCGACTTCCTCATCGTAGACGTCTCTCTGGTCAGCCTG GTGGCCAACACCCTGGGCTTTGCCGAGATGGGCCCCATCAAGTCACTGCGGACGCTGCGTGCACTCCGTCCTCTGAGAGCTCTGTCACGATTTGAGGGCA TGAGGGTGGTGGTCAATGCCCTGGTGGGCGCCATCCCGTCCATCATGAACGTCCTCCTCGTCTGCCTCATCTTCTGGCTCATCTTCAGCATCATGGGCGT GAACCTCTTTGCGGGGAAGTTTGGGAGGTGCATCAACCAGACAGAGGGAGACTTGCCTTTGAACTACACCATCGTGAACAACAAGAGCCAGTGTGAGTCC TTGAACTTGACCGGAGAATTGTACTGGACCAAGGTGAAAGTCAACTTTGACAACGTGGGGGCCGGGTACCTGGCCCTTCTGCAGGTGGCAACATTTAAAG GCTGGATGGACATTATGTATGCAGCTGTGGACTCCAGGGGGTATGAAGAGCAGCCTCAGTGGGAATACAACCTCTACATGTACATCTATTTTGTCATTTT CATCATCTTTGGGTCTTTCTTCACCCTGAACCTCTTTATTGGTGTCATCATTGACAACTTCAACCAACAGAAGAAAAAGTTAGGGGGCCAGGACATCTTC ATGACAGAGGAGCAGAAGAAGTACTACAATGCCATGAAGAAGCTGGGCTCCAAGAAGCCCCAGAAGCCCATCCCACGGCCCCTGAACAAGTACCAGGGCT TCATATTCGACATTGTGACCAAGCAGGCCTTTGACGTCACCATCATGTTTCTGATCTGCTTGAATATGGTGACCATGATGGTGGAGACAGATGACCAAAG TCCTGAGAAAATCAACATCTTGGCCAAGATCAACCTGCTCTTTGTGGCCATCTTCACAGGCGAGTGTATTGTCAAGCTGGCTGCCCTGCGCCACTACTAC TTCACCAACAGCTGGAATATCTTCGACTTCGTGGTTGTCATCCTCTCCATCGTGGGCACTGTGCTCTCGGACATCATCCAGAAGTACTTCTTCTCCCCGA CGCTCTTCCGAGTCATCCGCCTGGCCCGAATAGGCCGCATCCTCAGACTGATCCGAGGGGCCAAGGGGATCCGCACGCTGCTCTTTGCCCTCATGATGTC CCTGCCTGCCCTCTTCAACATCGGGCTGCTGCTCTTCCTCGTCATGTTCATCTACTCCATCTTTGGCATGGCCAACTTCGCTTATGTCAAGTGGGAGGCT GGCATCGACGACATGTTCAACTTCCAGACCTTCGCCAACAGCATGCTGTGCCTCTTCCAGATCACCACGTCGGCCGGCTGGGATGGCCTCCTCAGCCCCA TCCTCAACACTGGGCCGCCCTACTGCGACCCCACTCTGCCCAACAGCAATGGCTCTCGGGGGGACTGCGGGAGCCCAGCCGTGGGCATCCTCTTCTTCAC CACCTACATCATCATCTCCTTCCTCATCGTGGTCAACATGTACATTGCCATCATCCTGGAGAACTTCAGCGTGGCCACGGAGGAGAGCACCGAGCCCCTG AGTGAGGACGACTTCGATATGTTCTATGAGATCTGGGAGAAATTTGACCCAGAGGCCACTCAGTTTATTGAGTATTCGGTCCTGTCTGACTTTGCCGATG CCCTGTCTGAGCCACTCCGTATCGCCAAGCCCAACCAGATAAGCCTCATCAACATGGACCTGCCCATGGTGAGTGGGGACCGCATCCATTGCATGGACAT TCTCTTTGCCTTCACCAAAAGGGTCCTGGGGGAGTCTGGGGAGATGGACGCCCTGAAGATCCAGATGGAGGAGAAGTTCATGGCAGCCAACCCATCCAAG ATCTCCTACGAGCCCATCACCACCACACTCCGGCGCAAGCACGAAGAGGTGTCGGCCATGGTTATCCAGAGAGCCTTCCGCAGGCACCTGCTGCAACGCT CTTTGAAGCATGCCTCCTTCCTCTTCCGTCAGCAGGCGGGCAGCGGCCTCTCCGAAGAGGATGCCCCTGAGCGAGAGGGCCTCATCGCCTACGTGATGAG TGAGAACTTCTCCCGACCCCTTGGCCCACCCTCCAGCTCCTCCATCTCCTCCACTTCCTTCCCACCCTCCTATGACAGTGTCACTAGAGCCACCAGCGAT AACCTCCAGGTGCGGGGGTCTGACTACAGCCACAGTGAAGATCTCGCCGACTTCCCCCCTTCTCCGGACAGGGACCGTGAGTCCATCGTGTGAGCCTCGG CCTGGCTGGCCAGGACACACTGAAAAGCAGCCTTTTTCACCATGGCAAACCTAAATGCAGTCAGTCACAAACCAGCCTGGGGCCTTCCTGGCTTTGGGAG TAAGAAATGGGCCTCAGCCCCGCGGATCAACCAGGCAGAGTTCTGTGGCGCCGCGTGGACAGCCGGAGCAGTTGGCCTGTGCTTGGAGGCCTCAGATAGA CCTGTGACCTGGTCTGGTCAGGCAATGCCCTGCGGCTCTGGAAAGCAACTTCATCCCAGCTGCTGAGGCGAAATATAAAACTGAGACTGTATATGTTGTG AATGGGCTTTCATAAATTTATTATATTTGATATTTTTTTACTTGAGCAAAGAACTAAGGATTTTTCCATGGACATGGGCAGCAATTCACGCTGTCTCTTC TTAACCCTGAACAAGAGTGTCTATGGAGCAGCCGGAAGTCTGTTCTCAAAGCAGAAGTGGAATCCAGTGTGGCTCCCACAGGTCTTCACTGCCCAGGGGT CGAATGGGGTCCCCCTCCCACTTGACCTGAGATGCTGGGAGGGCTGAACCCCCACTCACACAAGCACACACACACAGTCCTCACACACGGAGGCCAGACA CAGGCCGTGGGACCCAGGCTCCCAGCCTAAGGGAGACAGGCCTTTCCCTGCCGGCCCCCCAAGGATGGGGTTCTTGTCCACGGGGCTCACTCTGGCCCCC TATTGTCTCCAAGGTCCCATTTTCCCCCTGTGTTTTCACGCAGGTCATATTGTCAGTCCTACAAAAATAAAAGGCTTCCAGAGGAGAGTGGCCTGGGTCC CAGGGCTGGCCCTAGGCACTGATAGTTGCCTTTTCTTCCCCTCCTGTAAGAGTATTAACAAAACCAAAGGACACAAGGGTGCAAGCCCCATTCACGGCCT GGCATGCAGCTTGTCCTTGCTCCTGGAACCTGGCAGGCCCTGCCCAGCCAGCCATCGGAAGAGAGGGCTGAGCCATGGGGGTTTGGGGCTAAGAAGTTCA CCAGCCCTGAGCCATGGCGGCCCCTCAGCCTGCCTGAAGAGAGGAAACTGGCGATCTCCCAGGGCTCTCTGGACCATACGCGGAGGAGTTTTCTGTGTGG TCTCCAGCTCCTCTCCAGACACAGAGACATGGGAGTGGGGAGCGGAGCTTGGCCCTGCGCCCTGTGCAGGGAAAGGGATGGTCAGGCCCAGTTCTCGTGC CCTTAGAGGGGAATGAACCATGGCACCTTTGAGAGAGGGGGCACTGTGGTCAGGCCCAGCCTCTCTGGCTCAGCCCGGGATCCTGATGGCACCCACACAG AGGACCTCTTTGGGGCAAGATCCAGGTGGTCCCATAGGTCTTGTGAAAAGGCTTTTTCAGGGAAAAATATTTTACTAGTCCAATCACCCCCAGGACCTCT TCAGCTGCTGACAATCCTATTTAGCATATGCAAATCTTTTAACATAGAGAACTGTCACCCTGAGGTAACAGGGTCAACTGGCGAAGCCTGAGCAGGCAGG GGCTTGGCTGCCCCATTCCAGCTCTCCCATGGAGCCCCTCCACCGGGCGCATGCCTCCCAGGCCACCTCAGTCTCACCTGCCGGCTCTGGGCTGGCTGCT CCTAACCTACCTCGCCGAGCTGTCGGAGGGCTGGACATTTGTGGCAGTGCTGAAGGGGGCATTGCCGGCGAGTAAAGTATTATGTTTCTTCTTGTCACCC CAGTTCCCTTGGTGGCAACCCCAGACCCAACCCATGCCCCTGACAGATCTAGTTCTCTTCTCCTGTGTTCCCTTTGAGTCCAGTGTGGGACACGGTTTAA CTGTCCCAGCGACATTTCTCCAAGTGGAAATCCTATTTTTGTAGATCTCCATGCTTTGCTCTCAAGGCTTGGAGAGGTATGTGCCCCTCCTGGGTGCTCA CCGCCTGCTACACAGGCAGGAATGCGGTTGGGAGGCAGGTCGGGCTGCCAGCCCAGCTGGCCGGAAGGAGACTGTGGTTTTTGTGTGTGTGGACAGCCCG GGAGCTTTGAGACAGGTGCCTGGGGCTGGCTGCAGACGGTGTGGTTGGGGGTGGGAGGTGAGCTAGACCCAACCCTTAGCTTTTAGCCTGGCTGTCACCT TTTTAATTTCCAGAACTGCACAATGACCAGCAGGAGGGAAGGACAGACATCAAGTGCCAGATGTTGTCTGAACTAATCGAGCACTTCTCACCAAACTTCA TGTATAAATAAAATACATATTTTTAAAACAAACCAATAAATGGCTTACATG

SCN5A.F9 (forward primer)
SCN5A.R10 (reverse primer)
Single exon skipping

Frame 0

GNVRRACAQKQDEKMANFLLPRGTSSFRRFTRE SLAAIEKRMAEKQARGSTTLQESREGLPEEEAPR PQLDLQASKKLPDLYGNPPQELIGEPLEDLDPF YSTQKTFIVLNKGKTIFRFSATNALYVLSPFHP IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP PPWTKYVEYTFTAIYTFESLVKILARGFCLHAF TFLRDPWNWLDFSVIIMAYVSENIKLGNLSALR TFRVLRALKTISVIPGLKTIVGALIQSVKKLADV MVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTA LNGTNGSVEADGLVWESLDLYLSDPENYLLKNG TSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYT SFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQ NQATIAETEEKEKRFQEAMEMLKKEHEALTIRGV DTVSRSSLEMSPLAPVNSHERRSKRRKRMSSGT EECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTS MKPRSSRGSIFTFRRRDLGSEADFADDENSTAGE SESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHA LHGKKNSTVDCNGVVSLLGAGDPEATSPGSHLL RPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGF EEPGARQRALSAVSVLTSALEELEESRHKCPPC WNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFT DLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGN LVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDS IIVILSLMELGLSRMSNLSVLRSFRLLRVFKLA KSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIF AVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFH AFLIIFRILCGEWIETMWDCMEVSGQSLCLLVF LLVMVIGNLVVLNLFLALLLSSFSADNLTAPDED REMNNLQLALARIQRGLRFVKRTTWDFCCGLLR QRPQKPAALAAQGQLPSCIATPYSPPPPETEKV PPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAE SDTDDQEEDEENSLGTEEESSKQQESQPVSGGP EAPPDSRTWSQVSATASSEAEASASQADWRQQW KAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQ IPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQA PGKVWWRLRKTCYHIVEHSWFETFIIFMILLSS GALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE MLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSL VANTLGFAEMGPIKSLRTLRALRPLRALSRFEG MRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGV NLFAGKFGRCINQTEGDLPLNYTIVNNKSQCES LNLTGELYWTKVKVNFDNVGAGYLALLQVATFK GWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIF IIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIF MTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQG FIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQS PEKINILAKINLLFVAIFTGECIVKLAALRHYY FTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSP TLFRVIRLARIGRILRLIRGAKGIRTLLFALMMS LPALFNIGLLLFLVMFIYSIFGMANFAYVKWEA GIDDMFNFQTFANSMLCLFQITTSAGWDGLLSP ILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFT TYIIISFLIVVNMYIAIILENFSVATEESTEPL SEDDFDMFYEIWEKFDPEATQFIEYSVLSDFAD ALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDI LFAFTKRVLGESGEMDALKIQMEEKFMAANPSK ISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQR SLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMS ENFSRPLGPPSSSSISSTSFPPSYDSVTRATSD NLQVRGSDYSHSEDLADFPPSPDRDRESIV*AS AWLARTH*KAAFFTMANLNAVSHKPAWGLPGFGS KKWASAPRINQAEFCGAAWTAGAVGLCLEASDR PVTWSGQAMPCGSGKQLHPSC*GEI*N*DCICC EWAFINLLYLIFFYLSKELRIFPWTWAAIHAVSS *P*TRVSMEQPEVCSQSRSGIQCGSHRSSLPRG RMGSPSHLT*DAGRAEPPLTQAHTHSPHTRRPD TGRGTQAPSLRETGLSLPAPQGWGSCPRGSLWPP IVSKVPFSPCVFTQVILSVLQK*KASRGEWPGS QGWP*ALIVAFSSPPVRVLTKPKDTRVQAPFTA WHAACPCSWNLAGPAQPAIGREG*AMGVWG*EVH QP*AMAAPQPA*REETGDLPGLSGPYAEEFSVW SPAPLQTQRHGSGERSLALRPVQGKGWSGPVLV PLEGNEPWHL*ERGHCGQAQPLWLSPGS*WHPHR GPLWGKIQVVP*VL*KGFFREKYFTSPITPRTS SAADNPI*HMQIF*HRELSP*GNRVNWRSLSRQ GLGCPIPALPWSPSTGRMPPRPPQSHLPALGWLL LTYLAELSEGWTFVAVLKGALPASKVLCFFLSP QFPWWQPQTQPMPLTDLVLFSCVPFESSVGHGL TVPATFLQVEILFL*ISMLCSQGLERYVPLLGAH RLLHRQECGWEAGRAASPAGRKETVVFVCVDSP GALRQVPGAGCRRCGWGWEVS*TQPLAFSLAVT FLISRTAQ*PAGGKDRHQVPDVV*TNRALLTKLH V*IKYIFLKQTNKWLT

Frame 1

AT*GEPVPRSRMRRWQTSYYLGAPAASAGSHGS PWQPSRSAWQRSKPAAQPPCRRAERGCPRRRLP GPSWTCRPPKSCQISMAIHPKSSSESPWRTWTPS IAPKRLSSY*IKARPSSGSVPPTPCMSSVPSTP SGERL*RFWFTRSSTCSSCAPSSPTACSWPSTT LHPGPSMSSTPSPPFTPLSLWSRFWLEASACTRS LSFGTHGTGWTLV*LSWRMYQKI*N*AICRLFE LSES*EL*KLFQLSQG*RPSWGP*SSL*RSWLM *WSSQSSASASLPSSACSSSWAT*GTSACATSQR STAPTAPWRPTAWSGNPWTFTSVIQKITCSRTA PLMCYCVGTALTLGHVRRATGA*RQARTPTTAT PASIPLPGPFLHSSA**RRTAGSASISRPSGPQG RST*SSSCLSSSWGPSTW*T*SWPWSQWPMRSK TKPPSLRPRRRKSASRRPWKCSRKNTRPSPSGV WIPCPVAPWRCPLWPQ*TAMREEARGENGCLQEL RSVGRTGSPSLTQKMVPEQ*IISASPVASAGLL *SHVPAAGAFSPFAGETWVLKQILQMMKTAQRG RARATTHHCWCPGPCAGPVPRDSPVPEPRLLATP SMAKRTALWTAMGWSHYWGQATQRPHPQEATSS AL*C*STRQTRPRHRRSQAGPRC*PPRLRV*MA SRSQEHGSGPSAQSASSPAHWKS*RSLATSVHHA GTVSPSAT*SGSAARCGCPSSRE*SWWSWTRLL TSPSLCASYSTHSSWRWSTTT*QVNSRRCCRSE TWSSQGFSQQR*PSRSLPSTPTTTSNRAGTSSTA SSSSLASWSWACPA*ATCRCCAPSACCGSSSWP NHGPP*THSSRSSGTQWGHWGT*HWC*PSSCSS LLWWACSSLARTTRS*GTATQACCLAGT*WTSFM PSSSSSASSVESGSRPCGTAWRCRGSHYACWSS CLLWSLATLWS*ISSWPCCSAPSVQTTSQPLMR TER*TTSSWPWPASRGACALSSGPPGISAVVSCG SGLRSPQPLPPRASCPAALPPPTPRHPQRRRRC LPPARKHGLRKASNQARAPPGIQSPCVCPSLWP SQTQMTKKKMRRTAWARRRSPASSRNPSLCPVAQ RPLRIPGPGARCQRLPPLRPRPVHLRPTGGSSG KRNPRPQGAVRPQRTVAPRAAQQT*PTPLSSWS RSLTSARMSRTQRTASLKAVSGAVPAVRWTPHRP QGRSGGGCARPATTSWSTAGSRHSSSS*SYSAV ERWPSRTST*RSGRPSRFCLSMPTRCSHMSSCW RCCSSGWPTASRSTSPMPGAGSTSSS*TSLWSAW WPTPWALPRWAPSSHCGRCVHSVL*ELCHDLRA *GWWSMPWWAPSRPS*TSSSSASSSGSSSASWA *TSLRGSLGGASTRQRETCL*TTPS*TTRASVSP *T*PENCTGPR*KSTLTTWGPGTWPFCRWQHLK AGWTLCMQLWTPGGMKSSLSGNTTSTCTSILSF SSSLGLSSP*TSLLVSSLTTSTNRRKS*GARTSS *QRSRRSTTMP*RSWAPRSPRSPSHGP*TSTRA SYSTL*PSRPLTSPSCF*SA*IW*P*WWRQMTK VLRKSTSWPRSTCSLWPSSQASVLSSWLPCATTT SPTAGISSTSWLSSSPSWALCSRTSSRSTSSPR RSSESSAWPE*AASSD*SEGPRGSARCSLPS*C PCLPSSTSGCCSSSSCSSTPSLAWPTSLMSSGRL ASTTCSTSRPSPTACCASSRSPRRPAGMASSAP SSTLGRPTATPLCPTAMALGGTAGAQPWASSSS PPTSSSPSSSWSTCTLPSSWRTSAWPRRRAPSP* VRTTSICSMRSGRNLTQRPLSLLSIRSCLTLPM PCLSHSVSPSPTR*ASSTWTCPW*VGTASIAWT FSLPSPKGSWGSLGRWTP*RSRWRRSSWQPTHPR SPTSPSPPHSGASTKRCRPWLSREPSAGTCCNA L*SMPPSSSVSRRAAASPKRMPLSERASSPT** VRTSPDPLAHPPAPPSPPLPSHPPMTVSLEPPAI TSRCGGLTTATVKISPTSPLLRTGTVSPSCEPR PGWPGHTEKQPFSPWQT*MQSVTNQPGAFLALG VRNGPQPRGSTRQSSVAPRGQPEQLACAWRPQID L*PGLVRQCPAALESNFIPAAEAKYKTETVYVV NGLS*IYYI*YFFT*AKN*GFFHGHGQQFTLSL LNPEQECLWSSRKSVLKAEVESSVAPTGLHCPGV EWGPPPT*PEMLGGLNPHSHKHTHTVLTHGGQT QAVGPRLPA*GRQAFPCRPPKDGVLVHGAHSGP LLSPRSHFPPVFSRRSYCQSYKNKRLPEESGLGP RAGPRH**LPFLPLL*EY*QNQRTQGCKPHSRP GMQLVLAPGTWQALPSQPSEERAEPWGFGAKKF TSPEPWRPLSLPEERKLAISQGSLDHTRRSFLCG LQLLSRHRDMGVGSGAWPCALCRERDGQAQFSC P*RGMNHGTFERGGTVVRPSLSGSARDPDGTHT EDLFGARSRWSHRSCEKAFSGKNILLVQSPPGPL QLLTILFSICKSFNIENCHPEVTGSTGEA*AGR GLAAPFQLSHGAPPPGACLPGHLSLTCRLWAGC S*PTSPSCRRAGHLWQC*RGHCRRVKYYVSSCHP SSLGGNPRPNPCP*QI*FSSPVFPLSPVWDTV* LSQRHFSKWKSYFCRSPCFALKAWRGMCPSWVL TACYTGRNAVGRQVGLPAQLAGRRLWFLCVWTAR EL*DRCLGLAADGVVGGGR*ARPNP*LLAWLSP F*FPELHNDQQEGRTDIKCQMLSELIEHFSPNF MYK*NTYF*NKPINGLH

Frame 2

QREESLCPEAG*EDGKLPITSGHQQLPQVHTGV PGSHREAHGREASPRLNHLAGEPRGAARGGGSP APAGPAGLQKAARSLWQSTPRAHRRAPGGPGPL L*HPKDFHRTE*RQDHLPVQCHQRLVCPQSLPPH PESGCEDSGSLALQHAHHVHHPHQLRVHGPARP STLDQVCRVHLHRHLHL*VSGQDSGSRLLPARV HFPSGPMELAGL*CDYHGVCIRKYKTRQFVGSSN FQSPESSKNYFSYPRAEDHRGGPDPVCEEAG*C DGPHSLLPQRLCPHRPAALHGQPKAQVRAQLHS AQRHQRLRGGRRLGLGIPGPLPQ*SRKLPAQERH L*CVTVWEQL*RWDMSGGLPVPKGRREPRPRLH QLRFLCLGLSCTLPPDDAGLLGAPLSADPQVRR EDLHDLLHACHLPGVLLPGEPDPGRGRNGL*GAK PSHHR*DRGEGKALPGGHGNAQERTRGPHHQGC GYRVP*LLGDVPFGPSKQP*EKKQEEKTDVFRN *GVWGGQAPQV*LRRWSQSNESSQPHPWPQQDFY EATFQPREHFHLSQARPGF*SRFCR**KQHSGG EREPPHITAGALAPAPDQCPGTAQSRNLGSWPR PPWQKEQHCGLQWGGLITGGRRPRGHIPRKPPPP PCDARAPARHDHAIGGARRAPDADLPGSVCRWL RGARSTAAGPQRSQRPHQRTGRVRGVSPQVSTM LEPSRPALPDLGVLPAVDVHQAGSEVGGHGPVY* PHHHYVHRTQHTLHGAGALQHDK*IRGDAAGRK PGLHRDFHSRDDLQDHCPRPLLLLPTGLEHLRQ HHRHP*PHGAGPVPHEQLVGAALLPPAAGLQAGQ IMAHPEHTHQDHRELSGGTGEPDTGASHHRVHL CCGGHAALWQELLGAEGQRLRPAASLAHDGLLS CLPHHLPHPLWRVDRDHVGLHGGVGAVIMPAGLL ACYGHWQPCGPESLPGLAAQLLQCRQPHSP**G QRDEQPPAGPGPHPEGPALCQADHLGFLLWSPA AAASEARSPCRPGPAAQLHCHPLLPATPRDGEGA SHPQGNTV*GRRATRPGHPRGSRARVCAHRCGR VRHR*PRRR*GEQPGHGGGVQQAAGIPACVRWP RGPSGFQDLEPGVSDCLL*GRGQCISGRLAAAVE SGTPGPRVR*DPRGQLLRGQHSRHDQHR*APGA DP*PRPGCQGPRGLLH*RLCPALSLLCGGHHTG PREGLVAVAQDLLPHRGAQLVRDIHHLHDPTQQW SAGLRGHLPRGAEDHQGSA*VCRQDVHICLRAG DAAQVGGLRLQEVLHQCLVLARLPHRRRLSGQP GGQHPGLCRDGPHQVTADAACTPSSESSVTI*GH EGGGQCPGGRHPVHHERPPRLPHLLAHLQHHGR EPLCGEVWEVHQPDRGRLAFELHHREQQEPV*V LELDRRIVLDQGESQL*QRGGRVPGPSAGGNI*R LDGHYVCSCGLQGV*RAASVGIQPLHVHLFCHF HHLWVFLHPEPLYWCHH*QLQPTEEKVRGPGHL HDRGAEEVLQCHEEAGLQEAPEAHPTAPEQVPGL HIRHCDQAGL*RHHHVSDLLEYGDHDGGDR*PK S*ENQHLGQDQPALCGHLHRRVYCQAGCPAPLL LHQQLEYLRLRGCHPLHRGHCALGHHPEVLLLPD ALPSHPPGPNRPHPQTDPRGQGDPHAALCPHDV PACPLQHRAAALPRHVHLLHLWHGQLRLCQVGG WHRRHVQLPDLRQQHAVPLPDHHVGRLGWPPQPH PQHWAALLRPHSAQQQWLSGGLREPSRGHPLLH HLHHHLLPHRGQHVHCHHPGELQRGHGGEHRAP E*GRLRYVL*DLGEI*PRGHSVY*VFGPV*LCRC PV*ATPYRQAQPDKPHQHGPAHGEWGPHPLHGH SLCLHQKGPGGVWGDGRPEDPDGGEVHGSQPIQ DLLRAHHHHTPAQARRGVGHGYPESLPQAPAATL FEACLLPLPSAGGQRPLRRGCP*ARGPHRLRDE *ELLPTPWPTLQLLHLLHFLPTLL*QCH*SHQR *PPGAGV*LQPQ*RSRRLPPFSGQGP*VHRVSLG LAGQDTLKSSLFHHGKPKCSQSQTSLGPSWLWE *EMGLSPADQPGRVLWRRVDSRSSWPVLGGLR* TCDLVWSGNALRLWKATSSQLLRRNIKLRLYML* MGFHKFIIFDIFLLEQRTKDFSMDMGSNSRCLF LTLNKSVYGAAGSLFSKQKWNPVWLPQVFTAQG SNGVPLPLDLRCWEG*TPTHTSTHTQSSHTEARH RPWDPGSQPKGDRPFPAGPPRMGFLSTGLTLAP YCLQGPIFPLCFHAGHIVSPTKIKGFQRRVAWV PGLALGTDSCLFFPSCKSINKTKGHKGASPIHGL ACSLSLLLEPGRPCPASHRKRGLSHGGLGLRSS PALSHGGPSACLKRGNWRSPRALWTIRGGVFCV VSSSSPDTETWEWGAELGPAPCAGKGMVRPSSRA LRGE*TMAPLREGALWSGPASLAQPGILMAPTQ RTSLGQDPGGPIGLVKRLFQGKIFY*SNHPQDL FSC*QSYLAYANLLT*RTVTLR*QGQLAKPEQAG AWLPHSSSPMEPLHRAHASQATSVSPAGSGLAA PNLPRRAVGGLDICGSAEGGIAGE*SIMFLLVT PVPLVATPDPTHAPDRSSSLLLCSL*VQCGTRFN CPSDISPSGNPIFVDLHALLSRLGEVCAPPGCS PPATQAGMRLGGRSGCQPSWPEGDCGFCVCGQP GSFETGAWGWLQTVWLGVGGELDPTLSF*PGCHL FNFQNCTMTSRREGQTSSARCCLN*SSTSHQTS CINKIHIFKTNQ*MAYM